JP2018082953A - Connector and catheter - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide a suction catheter and a connector for a suction catheter which can suppress blockage of a blood vessel.SOLUTION: A connector 12 of a suction catheter comprises: a tip opening 201 arranged on an end part of an axial direction tip side; a base end opening 202 arranged on an axial direction base end side end part; an inner space communicating the tip opening 201 and the base end opening 202, and extending in the axial direction; a blood vessel insertion part 21 having a diameter enlarged part 2121; a straight piping part 23 arranged on a base end side of the diameter enlarged part 212; and a recess 221 arranged on the base end side of the diameter enlarged part 212 and a tip side of the straight piping part 23. An outer diameter of the diameter enlarged part 212 increases gradually from the tip side to the base end side. An outer diameter of the straight piping part 23 is almost equal. An outer peripheral surface of the recess 221 becomes dent toward inside of the radial direction relative to a portion adjacent to the axial direction. Therefore, ligation with a blood vessel is performed on the recess 221, force for expanding the blood vessel acts on a tip side of the ligation position. Therefore, blockage of the blood vessel can be suppressed.SELECTED DRAWING: Figure 2

Description

  The present invention relates to a suction catheter and a connector used for the suction catheter.

  Conventionally, various catheters are used in surgical operations. In organ transplantation or partial excision after removing the organ outside the body and removing the tumor, etc., the organ may be removed from the body, transported, transplanted, or partially excised outside the body. . In these cases, the arteries and veins of the removed organ are connected to at least one arterial catheter and at least one venous catheter, and separated from other parts using auxiliary circulation means such as a pump connected to each catheter. Small-scale artificial blood circulation is established and maintained.

  Also, in so-called isolated perfusion in the administration of high-efficiency and high-side-effect drugs to organs or body regions, arterial catheters and venous catheters are connected to the arteries and veins of the target organ or body region, and artificial blood circulation is similarly performed. Established and maintained.

  When performing perfusion to such an organ or body region, for example, a catheter as shown in Patent Document 1 can be used as an arterial catheter or a venous catheter.

JP 1-23142

  When blood is aspirated from a suction catheter (venous catheter), the pressure in the blood vessel (vein) on the blood removal side drops, and the blood vessel is crushed and closed so that the inner walls of the blood vessels come into contact with each other. May occur. When blood is not smoothly drained in a venous catheter on the blood removal side that sends blood out of an organ or body region via a vein during perfusion, various problems are likely to occur due to blood suction. For example, excessive blood or perfusate is supplied to an organ or body region, which may adversely affect cells and tissues. In addition, if excessive decompression occurs in the venous catheter, blood cells may be destroyed.

  This invention is made | formed in view of such a situation, and it aims at providing the connector for suction catheters and suction catheters which can suppress occlusion of the blood vessel.

  In order to solve the above-mentioned problems, a first invention of the present application is a connector that is connected to an end portion of a tubular catheter body and is inserted into a blood vessel to constitute a catheter that sucks blood, and is an end portion on the distal end side in the axial direction A distal end opening disposed in the axial direction, a proximal end opening disposed in the proximal end on the axial direction, an internal space extending in the axial direction through the distal opening and the proximal end opening, and a distal end side A blood vessel insertion portion having an enlarged diameter portion whose outer diameter gradually increases from the proximal end side to the proximal end side, a straight tube portion which is disposed on the proximal end side of the enlarged diameter portion and whose outer diameter is substantially constant, and the enlarged diameter portion And a concave portion whose outer peripheral surface is recessed radially inward from a portion adjacent in the axial direction, disposed on the proximal end side of the portion and the distal end side of the straight pipe portion.

  2nd invention of this application is a connector of 1st invention, Comprising: The said recessed part is a cyclic | annular groove | channel connected in the circumferential direction.

  3rd invention of this application is a connector of 1st invention or 2nd invention, Comprising: The said blood vessel insertion part has a some through-hole which connects the said internal space and the space of radial direction outer side.

  4th invention of this application is a connector of 3rd invention, Comprising: The opening area of the said front-end | tip opening part is larger than each opening area of the said through-hole.

  5th invention of this application is a connector of 3rd invention or 4th invention, Comprising: The said some through-hole is arrange | positioned in three or more positions of the circumferential direction.

  A sixth invention of the present application is the connector according to any one of the third to fifth inventions, wherein the plurality of through holes are arranged at two or more positions in the axial direction.

  A seventh invention of the present application is the connector according to any one of the first to sixth inventions, wherein the enlarged-diameter portion includes a curved outer peripheral surface protruding outward and radially outward.

  An eighth invention of the present application is the connector according to any one of the first to seventh inventions, wherein the blood vessel insertion portion is disposed on a distal end side of the enlarged diameter portion, and is recessed toward a proximal end side and a radial inner side. A neck portion having a curved outer peripheral surface is further included.

  A ninth invention of the present application is the connector according to any one of the first to eighth inventions, wherein a distal end side is disposed upstream of the blood vessel and a proximal end side is downstream of the blood vessel when inserted into the blood vessel. Placed on the side.

  A tenth invention of the present application is the connector according to any one of the first to ninth inventions, wherein at the time of insertion into the blood vessel, at least a part of the enlarged diameter portion and the concave portion and the straight tube portion are provided. The blood vessel is ligated at an axial position located inside the blood vessel where the recess is located.

  An eleventh invention of the present application is the connector according to any one of the first to tenth inventions, wherein the connector is disposed on the most proximal side and gradually decreases in outer diameter from the distal end side toward the proximal end opening. It has further.

  A twelfth invention of the present application is the connector according to any one of the first invention to the eleventh invention, and is formed of a soft resin material.

  A thirteenth invention of the present application is a catheter having any one of the connectors of the first to twelfth inventions, and the tubular catheter body to which the connector is connected at one end.

  According to the first to thirteenth inventions of the present application, due to the step between the concave portion and the portion on the distal end side of the concave portion, a force that spreads radially outward is applied to the blood vessel on the distal end side of the concave portion. Thereby, it is suppressed that the inner walls of a blood vessel stick together and occlusion of the blood vessel occurs.

  According to the second invention of the present application, on the distal end side of the concave portion, a force that spreads the blood vessel outward in the radial direction acts on the entire circumference in the circumferential direction. Therefore, the occurrence of occlusion of blood vessels due to suction is further suppressed.

  According to the third invention of the present application, the suction force is not concentrated only on the distal end portion of the connector where the distal end opening portion is disposed, and the suction force is also generated on the side surface of the blood vessel insertion portion. By having a plurality of suction locations, the blood vessel does not stick to one location of the connector. Therefore, the occurrence of occlusion of blood vessels due to suction is suppressed.

  According to the fourth invention of the present application, the inside of the blood vessel and the internal space in the connector can be more reliably communicated with each other by making the tip opening that is easy to take a large distance from the inner wall of the blood vessel larger than each through hole. .

  According to the fifth and sixth inventions of the present application, the force for sucking the inner wall of the blood vessel to the connector is dispersed, and the occurrence of the occlusion of the blood vessel due to the suction is further suppressed.

  According to the seventh invention of the present application, even when the inner wall of the blood vessel sticks to the outer surface of the enlarged diameter portion, the inner walls of the blood vessel hardly stick to each other on the distal end side of the connector. As a result, the occlusion of blood vessels due to suction is further suppressed.

  According to the eighth invention of the present application, the blood vessel wall can be smoothly deformed along the outer peripheral surface of the neck portion when the connector is inserted into the blood vessel.

  According to the twelfth aspect of the present invention, the blood vessel is hardly damaged when the connector is inserted into the blood vessel. In addition, the connector can be deformed somewhat in accordance with the movement of the blood vessel while being inserted into the blood vessel. For this reason, blood vessels and perfusate are unlikely to leak at the connection between the blood vessel and the catheter.

1 is a partial side view of a catheter according to one embodiment. It is a side view of the connector concerning one embodiment. It is a front view of the connector concerning one embodiment. It is a fragmentary sectional view of the catheter concerning one embodiment. It is the schematic which showed the mode of the perfusion of the liver using the perfusion apparatus containing the catheter which concerns on one Embodiment. It is a fragmentary sectional view at the time of use of the catheter concerning one embodiment. It is a side view of the connector concerning one modification. It is a side view of the connector which concerns on another modification. It is sectional drawing of the connector which concerns on another modification. It is a side view of the connector which concerns on another modification. It is a side view of the connector which concerns on another modification. It is a side view of the connector which concerns on another modification. It is a side view of the connector which concerns on another modification.

  Embodiments of the present invention will be described below with reference to the drawings.

<1. Configuration of catheter>
FIG. 1 is a partial side view of a catheter 1 having a connector 12 according to the present invention. FIG. 2 is a side view of the connector 12. FIG. 3 is a front view of the connector 12 as viewed from the front end side. FIG. 4 is a partial cross-sectional view of the catheter 1. In each figure, the dimension ratio is partially exaggerated for convenience of explanation, and may be different from the actual ratio.

  The catheter 1 is a suction catheter (for blood removal) that is inserted into a blood vessel and sucks blood. As shown in FIG. 1, the catheter 1 includes a tubular catheter body 11 and a connector 12.

  The catheter body 11 is a long tube body. The catheter body 11 is a hollow tubular member having a lumen through which liquid can circulate, and can connect between one end and the other end in a liquid-tight and air-tight manner.

  The catheter body 11 is formed of a flexible material. In the present embodiment, the catheter body 11 is formed of a flexible synthetic resin. Examples of the material for forming the catheter body 11 include polyethylene, polypropylene, ethylene-propylene copolymer, polyolefin such as ethylene-vinyl acetate copolymer, thermoplastic resin such as soft polyvinyl chloride, silicone rubber, latex rubber, etc. These various rubbers, various elastomers such as polyurethane elastomer, polyamide elastomer, and polyester elastomer, and crystalline plastics such as polyamide, crystalline polyethylene, and crystalline polypropylene are used. In these materials, for example, an antithrombotic substance such as heparin, prostaglandin, urokinase, arginine derivative or the like may be blended or applied to the surface to impart antithrombogenicity.

  The connector 12 is a hollow tubular member disposed at the end of the catheter 1. The connector 12 has a flow path 20 (see FIG. 4) that is an internal space through which liquid can flow. The connector 12 is connected to one end of the catheter body 11. Specifically, a part of the connector 12 is inserted and fixed to one end of the catheter body 11. Thereby, the flow path 20 in the connector 12 communicates with the lumen of the catheter body 11.

  The connector 12 and the flow path 20 of this embodiment extend along the linear center axis 9. Further, each part of the connector 12 of the present embodiment is formed substantially rotationally symmetric with respect to the central axis 9. Hereinafter, the direction in which the flow path 20 extends is referred to as an “axial direction”. Of the connector 12, the side inserted into the catheter body 11 is “axial base end side” or simply “base end side”, and the side inserted into the blood vessel is the side opposite to the base end side. "Side" or simply "tip side". A direction orthogonal to the central axis 9 is referred to as a “radial direction”. In addition, although the central axis 9 of this embodiment was linear, this invention is not limited to this. The central axis 9 may be curved, and the connector 12 and the flow path 20 may be configured along the curved central axis 9.

  A tip opening 201 that communicates with the flow path 20 is provided at the end of the connector 12 on the tip side in the axial direction. In addition, a proximal end opening 202 that communicates with the flow path 20 is provided at the end of the connector 12 on the proximal end side in the axial direction.

  The material of the connector 12 may be a metal or a synthetic resin. In this embodiment, the connector 12 is integrally formed of a soft resin material. Thereby, when the connector 12 is inserted into the blood vessel, the blood vessel is hardly damaged. Further, even when the blood vessel moves while being inserted into the blood vessel, the connector 12 can be somewhat deformed in accordance with the movement of the blood vessel. For this reason, blood and perfusate are unlikely to leak at the connection between the blood vessel and the catheter 1. As a material for forming the connector 12, for example, a thermoplastic resin such as polycarbonate, polyamide, polysulfone, polyarylate, methacrylate styrene copolymer is used.

  As shown in FIG. 4, in the connector 12 of this embodiment, the flow path 20 extends linearly. As shown in FIGS. 2 and 4, the connector 12 has an axial direction from the distal end side toward the proximal end side in the order of the blood vessel insertion portion 21, the ligation portion 22, the straight tube portion 23, and the grip portion 24. Is placed adjacent to.

  The blood vessel insertion portion 21 has a neck portion 211, an enlarged diameter portion 212, and a cylindrical portion 213 in order from the distal end side toward the proximal end side. The neck portion 211, the enlarged diameter portion 212, and the cylindrical portion 213 are disposed adjacent to each other in the axial direction.

  The neck portion 211 is disposed on the distal end side of the enlarged diameter portion 212. The outer diameter of the neck portion 211 gradually increases from the distal end side toward the proximal end side. When inserting the connector 12 into the blood vessel, it is necessary to smoothly deform the blood vessel wall along the outer peripheral surface thereof. For this reason, the outer peripheral surface of the neck part 211 is an outwardly concave curved surface. Specifically, the neck portion 211 has a curved outer peripheral surface that is recessed proximally and radially inward. The outer peripheral surface of the neck portion 211 is preferably arcuate in a cross section passing through the central axis 9. Further, the radius of the arc is preferably 20% or less of the maximum outer diameter of the blood vessel insertion portion 21, and more preferably 10% or less. In the present embodiment, the neck portion 211 is disposed on the most distal end side in the axial direction of the connector 12. Thereby, when the connector 12 is inserted into the blood vessel, the blood vessel wall is more easily deformed.

  The outer diameter of the enlarged diameter portion 212 gradually increases from the distal end side toward the proximal end side. The outer peripheral surface of the enlarged diameter portion 212 is a curved surface that protrudes outward. Specifically, the enlarged diameter portion 212 includes a curved outer peripheral surface that protrudes to the distal end side and radially outward. The enlarged diameter portion 212 is disposed adjacent to the proximal end side of the neck portion 211. The cylindrical portion 213 has a cylindrical outer peripheral surface, and its outer diameter is substantially constant. The cylindrical portion 213 is disposed adjacent to the proximal end side of the enlarged diameter portion 212.

  The blood vessel insertion part 21 is provided with a plurality of through holes 210. The through-hole 210 communicates the flow path 20 and the space outside in the radial direction of the blood vessel insertion portion 21. Each through-hole 210 is substantially circular. The opening area of each through-hole 210 is smaller than the opening area of the tip opening 201. The through holes 210 are arranged at a plurality of locations in the circumferential direction in each of a plurality of locations in the axial direction. In the present embodiment, as shown in FIG. 2, the through holes 210 are arranged at five locations in the axial direction. At the axial position on the most distal end side in the axial direction, the through holes 210 are arranged at substantially equal intervals at four locations in the circumferential direction. At other axial positions, the through holes 210 are arranged at approximately equal intervals at eight locations in the circumferential direction.

  The ligation portion 22 is disposed on the proximal end side of the blood vessel insertion portion 21 and the distal end side of the straight tube portion 23. The ligation part 22 is provided with a recess 221 that is recessed inward in the radial direction from a portion adjacent in the axial direction. Therefore, the concave portion 221 is disposed on the proximal end side of the enlarged diameter portion 212 of the blood vessel insertion portion 21 and the distal end side of the straight tube portion 23. The recessed part 221 of this embodiment is an annular groove connected in the circumferential direction. For this reason, the recessed part 221 is arrange | positioned in the whole circumferential direction of the ligation part 22. FIG.

  When the catheter 1 is used, the blood vessel insertion portion 21, the ligation portion 22, and at least a part of the straight tube portion 23 are disposed in the blood vessel 8 (see FIG. 6). In the ligation portion 22, the blood vessel 8 is ligated and fixed to the connector 12 with a suture or the like. That is, the blood vessel 8 is ligated at the axial position where the recess 221 is located.

  The straight tube portion 23 is disposed on the proximal end side of the blood vessel insertion portion 21 and the ligation portion 22. The outer diameter of the straight pipe portion 23 is substantially constant.

  The grip portion 24 is disposed on the proximal end side of the straight pipe portion 23. The grip portion 24 is inserted into the catheter body 11. The grip portion 24 has a connection portion 241 disposed on the most proximal side of the connector 12. The connecting portion 241 has an outer diameter that gradually decreases from the distal end side toward the proximal end opening 202. Thereby, when inserting the grip portion 24 into the catheter body 11, it is easy to insert.

  An inner peripheral surface 200 constituting the flow path 20 in the connector 12 is a smooth curved surface. In the ligation part 22, the straight pipe part 23, and the part on the distal end side of the connection part 241 in the grip part 24, the inner peripheral surface 200 has a cylindrical shape with a substantially constant diameter. Thus, by making the diameter of the flow path 20 as constant as possible, the occurrence of pressure unevenness and turbulent flow in the flow path 20 is suppressed.

  In the neck portion 211 and the enlarged diameter portion 212 of the blood vessel insertion portion 21, the inner peripheral surface 200 gradually increases in diameter from the distal end side toward the proximal end side along the outer peripheral surface of the blood vessel insertion portion 21. In the cylindrical portion 213, the inner peripheral surface 200 gradually decreases in diameter from the distal end side toward the proximal end side so as to be smoothly connected to the cylindrical inner peripheral surface in the ligation portion 22 and the straight pipe portion 23.

  Further, in the connection portion 241 of the grip portion 24, the inner peripheral surface 200 gradually decreases in diameter from the distal end side toward the proximal end side along the outer peripheral surface of the connection portion 241.

<2. About use mode of catheter>
Next, how the catheter 1 is used will be described with reference to FIGS. 5 and 6. FIG. 5 is a schematic view showing a state of perfusion of the liver 40 using the perfusion apparatus 30. FIG. 6 is a partial cross-sectional view of the catheter 1 in use.

  This perfusion device 30 avoids the ischemic state and maintains or restores the function of the organ between the removal from the donor and the transplantation to the recipient and blood flow connection when organ transplantation is performed. An apparatus for perfusing perfusate to an organ. The perfusion apparatus 30 can also be applied to partial resection in which an organ is once removed from a living body, a lesioned part such as a tumor is removed outside the living body, and the organ is returned to the original living body. Below, the perfusion process with respect to the liver 40 in a liver transplant operation is demonstrated.

  The perfusion device 30 includes a reactor 31, a reservoir 32, a first inflow portion 33, a second inflow portion 34, and an outflow portion 35. The reactor 31 accommodates a liver 40 that is an organ to be perfused. The reservoir 32 stores a perfusate. The first inflow portion 33 and the second inflow portion 34 supply the perfusate from the reservoir 32 to the liver 40. The outflow part 35 collects the perfusate from the liver 40.

  The first inflow portion 33 includes an inflow catheter 331, a pump 332 inserted in the inflow catheter 331, a defoaming portion 333, and a temperature adjustment portion 334. The inflow catheter 331 connects the reservoir 32 to the common hepatic artery of the liver 40 or the right gastric artery branched from the common hepatic artery. Pump 332 pumps the perfusate from reservoir 32 to liver 40. The defoaming unit 333 defoams the perfusate flowing through the inflow catheter 331. The temperature adjustment unit 334 adjusts the temperature of the perfusate flowing through the inflow catheter 331.

  The second inflow part 34 includes an inflow catheter 341, a pump 342 inserted in the inflow catheter 341, a defoaming part 343, and a temperature adjustment part 344. The inflow catheter 341 connects the reservoir 32 and the superior mesenteric vein, inferior mesenteric vein, or splenic vein connected to the portal vein. Pump 342 pumps perfusate from reservoir 32 to liver 40. The defoaming unit 343 defoams the perfusate flowing through the inflow catheter 341. The temperature adjustment unit 344 adjusts the temperature of the perfusate flowing through the inflow catheter 341.

  The outflow part 35 includes a catheter 1 which is a suction catheter according to the present invention, a pump 351 and a gas supply module 352 inserted in the catheter 1, an oxygen supply part 353 and a carbon dioxide supply part 354.

  One end of the catheter 1 having the connector 12 is connected to the lower hepatic inferior vena cava or the right renal vein or the left renal vein that branches from the inferior inferior vena cava. The other end of the catheter 1 is connected to the reservoir 32. Thereby, the catheter 1 connects the reservoir 32 and the lower hepatic inferior vena cava of the liver 40.

  The pump 351 sucks the perfusate from the liver 40 and sends it to the reservoir 32. An oxygen supply unit 353 and a carbon dioxide supply unit 354 are connected to the gas supply module 352. Thereby, oxygen gas and carbon dioxide gas are supplied to the gas supply module 352 from the oxygen supply part 353 and the carbon dioxide supply part 354, respectively. The gas supply module 352 dissolves oxygen and carbon dioxide in the perfusate flowing through the catheter 1.

  In such a perfusion apparatus 30, the perfusion process can be performed on the liver 40 by driving the pumps 332, 342, 351 and the gas supply module 352. Note that the first inflow portion 33 and the second inflow portion 34 may employ a configuration in which the perfusate is supplied by gravity, such as an infusion bag, instead of the configuration in which the perfusate is pumped using the pumps 332 and 342. Good.

  In the above perfusion process, the catheter 1 that is a suction catheter is inserted and connected to the blood vessel 8 from which blood flows out of the liver 40 among the blood vessels extending from the liver 40. Therefore, as shown in FIG. 6, when the catheter 1 is inserted into the blood vessel 8, the distal end side is disposed on the upstream side of the blood vessel 8 and the proximal end side is disposed on the downstream side of the blood vessel 8.

  During the perfusion process, the catheter 1 sucks the perfusate in the blood vessel 8 through the connector 12. As shown in FIG. 6, when the liquid in the catheter 1 is sucked into the blood vessel 8 while being ligated and fixed, the distal end opening 201 and each through-hole 210 are directed from the outside of the connector 12 to the inside. A suction force is generated.

  In this connector 12, the recess 221 is constricted on the outer surface of the connector 12. When the blood vessel 8 and the connector 12 are ligated in the ligation part 22 by the ligature 80, as shown by an arrow in FIG. 6 due to a step between the recess 221 and the vicinity of the proximal end of the blood vessel insertion part 21 At the distal end side of the recess 221, a force that spreads outward in the radial direction acts on the blood vessel 8. As a result, it is suppressed that the inner walls of the blood vessel 8 are in contact with each other and the inner walls stick to each other. That is, when the connector 12 has a constriction on the outer surface, the occlusion of the blood vessel 8 due to suction is suppressed.

  The recessed part 221 of this embodiment is an annular groove connected in the circumferential direction as described above. For this reason, the force which expands the blood vessel 8 to the radial direction outer side acts on the front end side of the recessed part 221 over the perimeter of the circumferential direction. Therefore, the occlusion of the blood vessel 8 due to suction is further suppressed.

  In addition, an enlarged diameter portion 212 whose outer shape gradually decreases from the proximal end side toward the distal end side is disposed on the distal end side of the concave portion 221. For this reason, the distance between the inner wall of the blood vessel 8 and the outer peripheral surface of the connector 12 increases from the position where the force indicated by the arrow in FIG. For this reason, even if a suction force is applied to the through-hole 210 disposed on the side surface of the connector 12, the blood vessel 8 is difficult to stick to the outer surface of the connector 12. Therefore, the occlusion of the blood vessel 8 due to suction is further suppressed.

  In the present embodiment, as described above, the outer surface of the enlarged-diameter portion 212 has a curved shape that protrudes toward the distal end side and radially outward. For this reason, the angle of the said outer surfaces in the position which faces a circumferential direction becomes large as it goes to the front end side. Therefore, even when the inner wall of the blood vessel 8 is stuck to the outer surface of the enlarged diameter portion 212 by suction from the through hole 210 disposed in the enlarged diameter portion 212, the inner walls of the blood vessel 8 are connected to each other on the distal end side of the connector 12. Is hard to stick. As a result, the occlusion of the blood vessel 8 due to suction is further suppressed.

  In the connector 12 of this embodiment, the blood vessel insertion portion 21 has a plurality of through holes 210. Thereby, the suction force is not concentrated only on the distal end portion where the distal end opening 201 is disposed, and the suction force is also generated on the side surface of the blood vessel insertion portion 21. By having a plurality of suction locations, the blood vessel 8 does not stick to one location. Therefore, the occlusion of the blood vessel 8 is suppressed.

  As shown in FIGS. 2 and 3, the plurality of through holes 210 are disposed at three or more positions in the circumferential direction. In the present embodiment, depending on the position in the axial direction, there are a place where the through holes 210 are arranged at four places in the circumferential direction and a place where the through holes 210 are arranged at eight places in the circumferential direction. Moreover, since the arrangement position of the through-hole 210 is shifted depending on the position in the axial direction, the through-hole 210 is arranged at 16 places in the circumferential direction as a whole.

  If suction is performed at only one or two places in the circumferential direction, the place where the blood vessel 8 is sucked is biased in the circumferential direction. For this reason, the blood vessel 8 is likely to be blocked by suction. In particular, if suction is performed only at two locations facing each other in the circumferential direction, the inner walls of the blood vessel 8 are likely to approach each other, and the blood vessel 8 is particularly likely to be blocked by suction. By disposing the through holes 210 at three or more locations in the circumferential direction as in this embodiment, it is possible to further suppress the occlusion of the blood vessel 8 due to suction.

  The plurality of through holes 210 are arranged at two or more positions in the axial direction. The range in which the suction force is generated in the blood vessel insertion portion 21 is not biased in the axial direction, and the suction force can be applied in a wide range in the axial direction. Thereby, the force of sucking the inner wall of the blood vessel 8 to the connector 12 can be dispersed, and the occlusion of the blood vessel 8 due to suction can be further suppressed.

  In the connector 12 of the present embodiment, the opening area of the tip opening 201 is larger than the opening area of each through hole 210. The tip opening 201 arranged at the tip of the connector 12 communicates with the inner wall of the blood vessel 8 in contact with the blood vessel 8 even when the blood vessel 8 is curved or when an external force is applied to the blood vessel 8 and the connector 12. Is difficult to be blocked. Therefore, by making the tip opening 201 that is most likely to be the largest distance from the inner wall of the blood vessel 8 to be larger than each through-hole 210, the inside of the blood vessel 8 and the flow path 20 in the connector 12 are more reliably communicated. it can.

<3. Modification>
Although one embodiment of the present invention has been described above, the present invention is not limited to the above embodiment.

  FIG. 7 is a side view of a connector 12A according to a modification. In this connector 12A, the blood vessel insertion portion 21A has a weight portion 214A having a conical outer peripheral surface on the distal end side of a neck portion 211A having a curved outer peripheral surface that is concave outward. The weight portion 214A has a conical outer peripheral surface whose diameter gradually increases from the distal end side toward the proximal end side. As in the example of FIG. 7, the neck portion 211 </ b> A does not necessarily have to be disposed on the most distal end side of the connector 12 </ b> A.

  FIG. 8 is a side view of a connector 12B according to another modification. FIG. 9 is a cross-sectional view of the connector 12B taken along the line AA in FIG. In the example of FIGS. 8 and 9, the recess 221 </ b> B provided in the ligation part 22 </ b> B is arranged only in a part in the circumferential direction. In the ligation portion 22B, three concave portions 221B are arranged at substantially equal intervals in the circumferential direction. Thus, the recessed part 221B does not necessarily need to be arrange | positioned over the whole circumferential direction. Even in this case, by ligating the blood vessel and the connector 12B at the ligation portion 22B, the blood vessel on the distal end side of the recess 221B is expanded at the circumferential position where the recess 221B is disposed.

  FIG. 10 is a side view of a connector 12C according to another modification. The connector 12C in the example of FIG. 10 includes a blood vessel insertion portion 21C having a spherical outer peripheral surface. The blood vessel insertion portion 21C has a diameter-expanded portion 212C whose outer diameter gradually increases from the distal end side toward the proximal end side, and a reduced diameter portion 215C whose outer diameter gradually decreases from the distal end side toward the proximal end side. The outer peripheral surface of the enlarged diameter portion 212C is a curved surface that protrudes to the distal end side and radially outward. The reduced diameter portion 215C is a curved surface that is disposed on the proximal end side of the enlarged diameter portion 212C and protrudes to the proximal end side and radially outward. The enlarged diameter portion 212C and the reduced diameter portion 215C form a spherical outer peripheral surface as a whole.

  In the example of FIG. 10, a reduced diameter portion 215C that increases in diameter from the proximal end side toward the distal end side is disposed on the distal end side of the ligation portion 22C that is a ligation location. Is further expanded radially outward. For this reason, inner walls of blood vessels come into contact with each other, and the inner walls stick to each other. Therefore, the occurrence of occlusion of blood vessels due to suction is further suppressed.

  FIG. 11 is a side view of a connector 12D according to another modification. The connector 12D in the example of FIG. 11 has a blood vessel insertion portion 21D in a mesh shape. That is, a square through-hole 210D is arranged over the entire region of the blood vessel insertion portion 21D. And the space | interval of through-hole 210D is substantially constant. Thus, the total opening area of through-hole 210D can be enlarged by making blood vessel insertion part 21D into mesh shape. Therefore, the suction region on the side surface of the blood vessel insertion portion 21D can be further dispersed. Therefore, it is suppressed that the blood vessel is attracted to a specific portion of the blood vessel insertion portion 21D and the blood vessel is easily blocked.

  FIG. 12 is a side view of a connector 12E according to another modification. The connector 12E in the example of FIG. 12 has a plurality of through holes 210E extending in the axial direction. In the above embodiment, the through holes 210 are arranged at a plurality of locations in the axial direction of the blood vessel insertion portion 21. On the other hand, in the example of FIG. 12, each of the through holes 210E occupies most of the blood vessel insertion portion 21E in the axial direction. Even in such a case, in the blood vessel insertion portion 21E, the range in which the suction force is generated is not biased in the axial direction, and the suction force can be applied in a wide range in the axial direction. As a result, the force for sucking the inner wall of the blood vessel toward the connector 12E can be dispersed, and the occlusion of the blood vessel due to the suction can be suppressed.

  FIG. 13 is a side view of a connector 12F according to another modification. In the connector 12F in the example of FIG. 13, the through hole 210F provided in the side portion of the blood vessel insertion portion 21F and the distal end opening portion 201F are connected. Even in such a case, in the blood vessel insertion portion 21F, the range in which the suction force is generated is not biased in the axial direction, and the suction force can be applied in a wide range in the axial direction. As a result, the force for sucking the inner wall of the blood vessel toward the connector 12F can be dispersed, and the occlusion of the blood vessel due to the suction can be suppressed.

  The use of the connector and catheter of the present invention is not limited to liver perfusion treatment. Any other purpose may be used as long as the liquid is sucked from inside the blood vessel.

  Moreover, you may combine suitably each element which appeared in said embodiment and modification in the range which does not produce inconsistency.

  The terminology used herein is merely used to describe a particular embodiment. Thus, unless otherwise defined, there is no intention to limit the invention with the terms used herein.

DESCRIPTION OF SYMBOLS 1 Catheter 8 Blood vessel 9 Central axis 11 Catheter main body 12,12A, 12B, 12C12D12E, 12F Connector 20 Flow path 21,21A, 21C, 21D, 21E, 21F Blood vessel insertion part 22,22B, 22C Ligation part 23 Straight pipe part 24 Grasp Part 201, 201F Front end opening 202 Base end opening 210, 210D, 210E, 210F Through hole 211, 211A Neck part 212, 212C Expanded diameter part 213 Cylindrical part 214A Weighted part 215C Reduced diameter part 221, 221B Concave part 241 Connection part

Claims (13)

A connector that is connected to an end of a tubular catheter body and constitutes a catheter that is inserted into a blood vessel and sucks blood,
A tip opening disposed at the end on the tip side in the axial direction;
A proximal opening disposed at an axial proximal end; and
An internal space that communicates the distal end opening and the proximal end opening and extends in the axial direction;
A blood vessel insertion portion having an enlarged diameter portion whose outer diameter gradually increases from the distal end side toward the proximal end side;
A straight pipe portion disposed on the proximal end side of the diameter-expanded portion and having an outer diameter substantially constant;
A concave portion that is disposed on the proximal end side of the enlarged diameter portion and the distal end side of the straight pipe portion, and whose outer peripheral surface is recessed radially inward from a portion adjacent in the axial direction;
Having a connector. The connector according to claim 1,
The said recessed part is a connector which is a cyclic | annular groove | channel connected in the circumferential direction. The connector according to claim 1 or 2, wherein
The blood vessel insertion part is
The connector which has several through-holes which connect the said internal space and the space of radial direction outer side. The connector according to claim 3,
An opening area of the tip opening is larger than each opening area of the through hole. The connector according to claim 3 or 4, wherein
The plurality of through holes are connectors arranged at three or more positions in the circumferential direction. The connector according to any one of claims 3 to 5,
The plurality of through holes are connectors arranged at two or more positions in the axial direction. The connector according to any one of claims 1 to 6,
The expanded diameter portion is
A connector comprising a curved outer peripheral surface protruding outward and radially outward. The connector according to any one of claims 1 to 7,
The blood vessel insertion part is
A connector further comprising a neck portion that is disposed on a distal end side of the diameter-expanded portion and has a curved outer peripheral surface that is recessed proximally and radially inward. The connector according to any one of claims 1 to 8,
A connector in which a distal end side is disposed upstream of the blood vessel and a proximal end side is disposed downstream of the blood vessel when inserted into the blood vessel. The connector according to any one of claims 1 to 9,
At the time of insertion into the blood vessel, at least a part of the enlarged diameter portion and the concave portion and the straight pipe portion are disposed inside the blood vessel, and the blood vessel is ligated at an axial position where the concave portion is located. connector. The connector according to any one of claims 1 to 10,
A connector further comprising a connection portion that is disposed on the most proximal side and has an outer diameter that gradually decreases from the distal end side toward the proximal end opening. The connector according to any one of claims 1 to 11,
A connector made of a soft resin material. A connector according to any one of claims 1 to 12,
The tubular catheter body to which the connector is connected at one end;
Having a catheter.

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