JP2018078947A - Overtube for endoscope - Google Patents
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Abstract
Description
本発明は、内視鏡用オーバーチューブに関する。 The present invention relates to an endoscope overtube.
従来、被験者の口部から消化器に内視鏡を挿入する際に、該内視鏡の挿入を補助する内視鏡用オーバーチューブが知られている。 2. Description of the Related Art Conventionally, an endoscope overtube that assists insertion of an endoscope when the endoscope is inserted into a digestive organ from the mouth of a subject is known.
前記内視鏡用オーバーチューブは、まず、前記内視鏡に外挿された状態で食道から消化器に挿入されたのち、該内視鏡のみが抜去され、該内視鏡用オーバーチューブが留置される。そして、留置された前記内視鏡用オーバーチューブを利用して前記内視鏡を消化器等の臓器に出し入れして、組織採取、異物摘出、止血、腫瘍摘出、胆石の破砕等の手技を施すことにより、各種の治療、検査等が行われる。前記内視鏡による治療としては、例えば、ＥＳＤ（内視鏡的粘膜下層剥離術）、ＥＡＭ（内視鏡的吸引粘膜切除術）、ＥＶＬ（食道静脈瘤結紮術）等を挙げることができる。 The endoscope overtube is first inserted into the digestive tract from the esophagus in the state of being extrapolated to the endoscope, and then only the endoscope is removed, and the endoscope overtube is placed in place. Is done. Then, using the placed endoscope overtube, the endoscope is taken in and out of an organ such as a digestive organ, and procedures such as tissue collection, foreign body extraction, hemostasis, tumor removal, and crushing of gallstones are performed. As a result, various treatments and examinations are performed. Examples of the treatment using the endoscope include ESD (endoscopic submucosal dissection), EAM (endoscopic suction mucosal resection), and EVL (esophageal varices ligation).
前記内視鏡の表面には潤滑剤が塗布されているが、さらに前記内視鏡の操作性向上、手技時間の短縮、該潤滑剤の使用量低減等のために、表面に親水性潤滑剤からなるコーティング層を備える内視鏡用オーバーチューブが検討されており、各種親水性潤滑剤が提案されている。 A lubricant is applied to the surface of the endoscope. In order to further improve the operability of the endoscope, shorten the procedure time, reduce the amount of the lubricant used, etc., a hydrophilic lubricant is applied to the surface. Endoscope overtubes having a coating layer made of these materials have been studied, and various hydrophilic lubricants have been proposed.
前記親水性潤滑剤として、例えば、ポリビニルピロリドンと、シクロヘキサノンと、テトラヒドロフランと、乳酸エチルとを含むものが知られている（例えば、特許文献１参照）。 As the hydrophilic lubricant, for example, one containing polyvinylpyrrolidone, cyclohexanone, tetrahydrofuran, and ethyl lactate is known (for example, see Patent Document 1).
しかしながら、特許文献１記載の親水性潤滑剤は独特の香気があり、被験者によっては該香気が好まれないため、内視鏡用オーバーチューブを被験者の口部から食道を介して消化器に挿入する際の障害になることがあるという不都合がある。 However, since the hydrophilic lubricant described in Patent Document 1 has a unique aroma and some subjects do not like the aroma, the endoscope overtube is inserted into the digestive organ through the mouth of the subject via the esophagus. There is an inconvenience that it may become an obstacle.
本発明は、かかる不都合を解消して、被験者の口部から食道を介して消化器に挿入する際の障害を低減することができる内視鏡用オーバーチューブを提供することを目的とする。 An object of the present invention is to provide an endoscope overtube that can eliminate such inconvenience and can reduce an obstacle when the subject is inserted into the digestive organ through the esophagus from the mouth.
本発明者らは、特許文献１記載の親水性潤滑剤が独特の香気を備える理由について種々検討した結果、該香気が乳酸エチルに由来することを知見した。本発明者らは前記知見に基づいてさらに検討を重ねた結果、乳酸エチルの一部をエタノールで置き換えることにより、前記親水性潤滑剤の性能を損なうことなく前記香気を低減できることを見出し、本発明に到達した。 As a result of various studies on the reason why the hydrophilic lubricant described in Patent Document 1 has a unique fragrance, the present inventors have found that the fragrance is derived from ethyl lactate. As a result of further investigations based on the above findings, the present inventors have found that by replacing a part of ethyl lactate with ethanol, the aroma can be reduced without impairing the performance of the hydrophilic lubricant. Reached.
そこで、前記目的を達成するために、本発明の内視鏡用オーバーチューブは、体内への内視鏡の挿入を補助する内視鏡用オーバーチューブにおいて、表面に親水性潤滑剤からなるコーティング層を備え、該親水性潤滑剤は全量に対し、１〜８質量％のポリビニルピロリドンと、１０〜４０質量％のシクロヘキサノンと、４０〜６０質量％のテトラヒドロフランと、１〜２５質量％の乳酸エチルと、１〜２０質量％のエタノールとを含むことを特徴とする。 Therefore, in order to achieve the above object, the endoscope overtube of the present invention is a coating layer made of a hydrophilic lubricant on the surface of the endoscope overtube for assisting insertion of the endoscope into the body. The hydrophilic lubricant is based on the total amount of 1 to 8% by weight of polyvinylpyrrolidone, 10 to 40% by weight of cyclohexanone, 40 to 60% by weight of tetrahydrofuran, and 1 to 25% by weight of ethyl lactate. 1 to 20% by mass of ethanol.
本発明の内視鏡用オーバーチューブにおいて、前記親水性潤滑剤に含まれるポリビニルピロリドンは親水性ポリマーであり、生理的食塩水又は内視鏡に塗布される潤滑剤の存在下に湿潤状態となったときに潤滑性能を発揮する。ポリビニルピロリドンは、前記親水性潤滑剤の全量に対し１質量％未満では湿潤状態となったときにも潤滑性能を発揮することができず、該親水性潤滑剤の全量に対し８質量％を超えてもそれ以上の潤滑性能を得ることはできない。 In the endoscope overtube of the present invention, polyvinylpyrrolidone contained in the hydrophilic lubricant is a hydrophilic polymer, and becomes wet in the presence of physiological saline or a lubricant applied to the endoscope. Exhibits lubrication performance when When the polyvinyl pyrrolidone is less than 1% by mass relative to the total amount of the hydrophilic lubricant, the lubricating performance cannot be exerted even when wet, and exceeds 8% by mass with respect to the total amount of the hydrophilic lubricant. However, no more lubrication performance can be obtained.
また、シクロヘキサノン及びテトラヒドロフランは、前記内視鏡用オーバーチューブの表面にポリビニルピロリドンを結合する結合剤として作用する。前記親水性潤滑剤の全量に対し、シクロヘキサノンが１０質量％未満又はテトラヒドロフランが４０質量％未満では、前記内視鏡用オーバーチューブの表面にポリビニルピロリドンを結合することができない。また、前記親水性潤滑剤の全量に対し、シクロヘキサノンが４０質量％を超えるか、又はテトラヒドロフランが６０質量％を超えると、相対的にポリビニルピロリドンの含有量が低下し、湿潤状態となったときにも潤滑性能を発揮することができない。 Cyclohexanone and tetrahydrofuran act as a binder that binds polyvinylpyrrolidone to the surface of the endoscope overtube. If the cyclohexanone is less than 10% by mass or the tetrahydrofuran is less than 40% by mass with respect to the total amount of the hydrophilic lubricant, polyvinylpyrrolidone cannot be bonded to the surface of the endoscope overtube. Further, when cyclohexanone exceeds 40% by mass or tetrahydrofuran exceeds 60% by mass with respect to the total amount of the hydrophilic lubricant, when the content of polyvinyl pyrrolidone is relatively lowered and the wet state is obtained. Even the lubrication performance cannot be demonstrated.
また、乳酸エチル及びエタノールは、ポリビニルピロリドンの溶剤として作用する。乳酸エチルは、前記親水性潤滑剤の全量に対し１質量％未満では、ポリビニルピロリドンを溶解することができない。また、乳酸エチルは、前記親水性潤滑剤の全量に対し２５質量％を超えると、該親水性潤滑剤の香気を低減する効果を得ることができない。 Ethyl lactate and ethanol act as a solvent for polyvinyl pyrrolidone. When ethyl lactate is less than 1% by mass with respect to the total amount of the hydrophilic lubricant, polyvinylpyrrolidone cannot be dissolved. Moreover, when ethyl lactate exceeds 25 mass% with respect to the whole quantity of the said hydrophilic lubricant, the effect which reduces the aroma of this hydrophilic lubricant cannot be acquired.
一方、エタノールは、前記親水性潤滑剤の全量に対し１質量％未満では、前記親水性潤滑剤の香気を低減する効果を得ることができない。また、エタノールは、前記親水性潤滑剤の全量に対し２０質量％を超えると、ポリビニルピロリドンを溶解することができない。 On the other hand, if ethanol is less than 1% by mass relative to the total amount of the hydrophilic lubricant, the effect of reducing the aroma of the hydrophilic lubricant cannot be obtained. Moreover, when ethanol exceeds 20 mass% with respect to the whole quantity of the said hydrophilic lubricant, polyvinylpyrrolidone cannot be dissolved.
本発明の内視鏡用オーバーチューブは、例えば、外筒チューブと、該外筒チューブの内側に挿入され内視鏡が挿通可能な内筒チューブとを備え、該外筒チューブの内外面に前記コーティング層を備える構成とすることができる。 The endoscope overtube according to the present invention includes, for example, an outer tube, and an inner tube that is inserted inside the outer tube and into which the endoscope can be inserted. It can be set as the structure provided with a coating layer.
次に、添付の図面を参照しながら本発明の実施の形態についてさらに詳しく説明する。 Next, embodiments of the present invention will be described in more detail with reference to the accompanying drawings.
図１に示すように、本実施形態の内視鏡用オーバーチューブ１は、体内への内視鏡の挿入を補助する際に、被験者の口部から食道を介して消化器に挿入されるものであり、外筒チューブ１０と、内筒チューブ２０とからなる。 As shown in FIG. 1, the endoscope overtube 1 of this embodiment is inserted into the digestive organ from the mouth of a subject via the esophagus when assisting the insertion of the endoscope into the body. And consists of an outer tube 10 and an inner tube 20.
外筒チューブ１０は、図２Ａに示すように、ポリ塩化ビニル等の軟質樹脂からなる外筒チューブ本体１１と、外筒チューブ本体１１の基端部に取着されたＡＢＳ等の樹脂からなる外筒グリップ１２とからなる。外筒グリップ１２は、外周面の互いに対向する位置に１対のロックキャップ１３を備え、ロックキャップ１３により図示しないバイトブロック（マウスピース）に係止されるようになっている。外筒チューブ１０は、外筒チューブ本体１１の外面で消化管壁に接触する一方、外筒チューブ本体１１の内面が内視鏡（図示せず）及び内筒チューブ２０の挿入又は抜去の通路となる。 As shown in FIG. 2A, the outer tube 10 includes an outer tube tube body 11 made of a soft resin such as polyvinyl chloride, and an outer tube made of a resin such as ABS attached to the base end portion of the outer tube body 11. It consists of a cylinder grip 12. The outer cylinder grip 12 includes a pair of lock caps 13 at positions facing each other on the outer peripheral surface, and is locked to a bite block (mouthpiece) (not shown) by the lock cap 13. The outer tube 10 is in contact with the digestive tract wall at the outer surface of the outer tube body 11, while the inner surface of the outer tube body 11 is an endoscope (not shown) and a passage for inserting or removing the inner tube 20. Become.
また、内筒チューブ２０は、図２Ｂに示すように、ポリ塩化ビニル等の軟質樹脂からなる内筒チューブ本体２１と、内筒チューブ本体２１の基端部に取着されたＡＢＳ等の樹脂からなる内筒グリップ２２とからなる。内筒チューブ２０は、外筒チューブ１０の内側に挿入されることにより、外筒チューブ１０の内壁と内視鏡外面との間隙を低減し、該間隙に消化管粘膜の巻き込みを防止する作用を備えている。 2B, the inner tube 20 is made of an inner tube body 21 made of a soft resin such as polyvinyl chloride, and a resin such as ABS attached to the base end portion of the inner tube body 21. And an inner cylinder grip 22. The inner tube 20 is inserted inside the outer tube 10 to reduce the gap between the inner wall of the outer tube 10 and the outer surface of the endoscope, and to prevent the digestive tract mucosa from being caught in the gap. I have.
内視鏡用オーバーチューブ１は、前述のように外筒チューブ１０の外筒チューブ本体１１がその外面で消化管壁に接触する一方、その内面が内視鏡（図示せず）及び内筒チューブ２０の挿入又は抜去の通路となる。そこで、内視鏡用オーバーチューブ１は、例えば、外筒チューブ本体１１の内外面に親水性潤滑剤からなるコーティング層（図示せず）を備えている。 In the endoscope overtube 1, as described above, the outer tube body 11 of the outer tube 10 contacts the digestive tract wall on its outer surface, while its inner surface is an endoscope (not shown) and the inner tube. 20 passages for insertion or removal. Therefore, the endoscope overtube 1 includes, for example, a coating layer (not shown) made of a hydrophilic lubricant on the inner and outer surfaces of the outer tube main body 11.
本実施形態の内視鏡用オーバーチューブ１において、前記親水性潤滑剤は、全量に対し、１〜８質量％のポリビニルピロリドンと、１０〜４０質量％のシクロヘキサノンと、４０〜６０質量％のテトラヒドロフランと、１〜２５質量％の乳酸エチルと、１〜２０質量％のエタノールとを含む。 In the endoscope overtube 1 of the present embodiment, the hydrophilic lubricant is 1 to 8% by mass of polyvinylpyrrolidone, 10 to 40% by mass of cyclohexanone, and 40 to 60% by mass of tetrahydrofuran with respect to the total amount. And 1 to 25% by mass of ethyl lactate and 1 to 20% by mass of ethanol.
前記親水性潤滑剤において、ポリビニルピロリドンは親水性ポリマーであり、生理的食塩水又は内視鏡に塗布される潤滑剤の存在下に湿潤状態となったときに潤滑性能を発揮する。ポリビニルピロリドンは、前記親水性潤滑剤の全量に対し、好ましくは１〜３質量％とされる。 In the hydrophilic lubricant, polyvinyl pyrrolidone is a hydrophilic polymer, and exhibits lubricating performance when in a wet state in the presence of a physiological saline solution or a lubricant applied to an endoscope. The polyvinyl pyrrolidone is preferably 1 to 3% by mass with respect to the total amount of the hydrophilic lubricant.
また、シクロヘキサノン及びテトラヒドロフランは、前記内視鏡用オーバーチューブの表面にポリビニルピロリドンを結合する結合剤として作用する。シクロヘキサノンは、前記親水性潤滑剤の全量に対し、好ましくは１０〜３０質量％とされる。また、テトラヒドロフランは、前記親水性潤滑剤の全量に対し、好ましくは４５〜５５質量％とされる。 Cyclohexanone and tetrahydrofuran act as a binder that binds polyvinylpyrrolidone to the surface of the endoscope overtube. Cyclohexanone is preferably 10 to 30% by mass with respect to the total amount of the hydrophilic lubricant. Tetrahydrofuran is preferably 45 to 55% by mass with respect to the total amount of the hydrophilic lubricant.
また、乳酸エチル及びエタノールは、ポリビニルピロリドンの溶剤として作用する。乳酸エチルは、前記親水性潤滑剤の全量に対し、好ましくは５〜１５質量％とされる。また、エタノールは、前記親水性潤滑剤の全量に対し、好ましくは５〜１５質量％とされる。 Ethyl lactate and ethanol act as a solvent for polyvinyl pyrrolidone. The ethyl lactate is preferably 5 to 15% by mass with respect to the total amount of the hydrophilic lubricant. Moreover, ethanol is preferably 5 to 15% by mass with respect to the total amount of the hydrophilic lubricant.
ここで、エタノールは、ポリビニルピロリドンの溶剤としての乳酸エチルの一部を代替する成分として用いられ、前記範囲の量とすることにより乳酸エチルに由来する前記親水性潤滑剤の独特の香気を低減ことができる。この結果、本実施形態の内視鏡用オーバーチューブ１は、被験者の口部から食道を介して消化器に挿入する際の障害を低減する効果を得ることができる。 Here, ethanol is used as an alternative component of ethyl lactate as a solvent for polyvinyl pyrrolidone, and by reducing the amount of the hydrophilic lubricant derived from ethyl lactate by setting the amount within the above range. Can do. As a result, the endoscope overtube 1 according to the present embodiment can obtain an effect of reducing obstacles when inserted into the digestive organ from the mouth of the subject via the esophagus.
尚、本実施形態では、外筒チューブ本体１１の内外面に前記コーティング層を備える構成としているが、該コーティング層は内筒チューブ本体２１の内外面にも備えるようにしてもよい。また、本実施形態では、内視鏡用オーバーチューブ１は、外筒チューブ１０と内筒チューブ２０とからなる構成としているが、外筒チューブ１０のみからなるものであってもよい。 In the present embodiment, the coating layer is provided on the inner and outer surfaces of the outer tube body 11, but the coating layer may be provided on the inner and outer surfaces of the inner tube body 21. In the present embodiment, the endoscope overtube 1 is composed of the outer tube 10 and the inner tube 20, but may be composed of only the outer tube 10.
１…内視鏡用オーバーチューブ、 １０…外筒チューブ、 ２０…内筒チューブ。 DESCRIPTION OF SYMBOLS 1 ... End tube for endoscopes, 10 ... Outer tube, 20 ... Inner tube.
Claims (2)
表面に親水性潤滑剤からなるコーティング層を備え、該親水性潤滑剤は全量に対し、１〜８質量％のポリビニルピロリドンと、１０〜４０質量％のシクロヘキサノンと、４０〜６０質量％のテトラヒドロフランと、１〜２５質量％の乳酸エチルと、１〜２０質量％のエタノールとを含むことを特徴とする内視鏡用オーバーチューブ。 In the endoscope overtube that assists the insertion of the endoscope into the body,
A coating layer made of a hydrophilic lubricant is provided on the surface, and the hydrophilic lubricant is 1 to 8% by mass of polyvinylpyrrolidone, 10 to 40% by mass of cyclohexanone, and 40 to 60% by mass of tetrahydrofuran with respect to the total amount. 1 to 25% by mass of ethyl lactate and 1 to 20% by mass of ethanol.
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| JP2016523593A (en) * | 2013-05-16 | 2016-08-12 | サーモディクス，インコーポレイテッド | Compositions and methods for delivering hydrophobic bioactive agents |
| JP2016523844A (en) * | 2013-08-01 | 2016-08-12 | リクウィッド， インコーポレイテッド | Method for restoring hair and skin |
| WO2015107994A1 (en) * | 2014-01-15 | 2015-07-23 | 学校法人慶應義塾 | Surgical tool insertion aid |
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