JP2018075057A - Skin-pasting pressure sensitive adhesive sheet, and production method thereof - Google Patents
Skin-pasting pressure sensitive adhesive sheet, and production method thereof Download PDFInfo
- Publication number
- JP2018075057A JP2018075057A JP2016216989A JP2016216989A JP2018075057A JP 2018075057 A JP2018075057 A JP 2018075057A JP 2016216989 A JP2016216989 A JP 2016216989A JP 2016216989 A JP2016216989 A JP 2016216989A JP 2018075057 A JP2018075057 A JP 2018075057A
- Authority
- JP
- Japan
- Prior art keywords
- sensitive adhesive
- adhesive layer
- pressure
- hot
- skin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000004820 Pressure-sensitive adhesive Substances 0.000 title claims abstract description 151
- 238000004519 manufacturing process Methods 0.000 title claims abstract description 12
- 239000010410 layer Substances 0.000 claims abstract description 107
- 239000006260 foam Substances 0.000 claims abstract description 32
- 239000004831 Hot glue Substances 0.000 claims abstract description 19
- 239000012943 hotmelt Substances 0.000 claims description 80
- 239000000853 adhesive Substances 0.000 claims description 54
- 230000001070 adhesive effect Effects 0.000 claims description 50
- 238000000034 method Methods 0.000 claims description 11
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 11
- 230000005540 biological transmission Effects 0.000 claims 1
- 208000003251 Pruritus Diseases 0.000 abstract description 14
- 230000007803 itching Effects 0.000 abstract description 14
- 239000011800 void material Substances 0.000 abstract description 4
- PPBRXRYQALVLMV-UHFFFAOYSA-N Styrene Natural products C=CC1=CC=CC=C1 PPBRXRYQALVLMV-UHFFFAOYSA-N 0.000 description 22
- 238000000576 coating method Methods 0.000 description 19
- 239000011248 coating agent Substances 0.000 description 17
- 239000011347 resin Substances 0.000 description 17
- 229920005989 resin Polymers 0.000 description 17
- -1 styrene-ethylene-butylene-styrene Chemical class 0.000 description 17
- 239000002390 adhesive tape Substances 0.000 description 15
- 239000012790 adhesive layer Substances 0.000 description 14
- 150000003839 salts Chemical class 0.000 description 13
- 239000003242 anti bacterial agent Substances 0.000 description 9
- 239000003205 fragrance Substances 0.000 description 9
- 230000035699 permeability Effects 0.000 description 9
- 230000000052 comparative effect Effects 0.000 description 8
- 238000010438 heat treatment Methods 0.000 description 8
- 229920001577 copolymer Polymers 0.000 description 7
- 239000000463 material Substances 0.000 description 7
- 229920000139 polyethylene terephthalate Polymers 0.000 description 7
- 239000005020 polyethylene terephthalate Substances 0.000 description 7
- 229920005830 Polyurethane Foam Polymers 0.000 description 6
- 239000003963 antioxidant agent Substances 0.000 description 6
- 235000006708 antioxidants Nutrition 0.000 description 6
- 239000003795 chemical substances by application Substances 0.000 description 6
- 239000002480 mineral oil Substances 0.000 description 6
- 235000010446 mineral oil Nutrition 0.000 description 6
- 238000002156 mixing Methods 0.000 description 6
- 239000011496 polyurethane foam Substances 0.000 description 6
- 229920006132 styrene block copolymer Polymers 0.000 description 6
- 150000001875 compounds Chemical class 0.000 description 5
- 229920000346 polystyrene-polyisoprene block-polystyrene Polymers 0.000 description 5
- 239000011148 porous material Substances 0.000 description 5
- 229920001935 styrene-ethylene-butadiene-styrene Polymers 0.000 description 5
- 235000007586 terpenes Nutrition 0.000 description 5
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 4
- ISWSIDIOOBJBQZ-UHFFFAOYSA-N Phenol Chemical compound OC1=CC=CC=C1 ISWSIDIOOBJBQZ-UHFFFAOYSA-N 0.000 description 4
- 239000006096 absorbing agent Substances 0.000 description 4
- 230000003078 antioxidant effect Effects 0.000 description 4
- 229910052799 carbon Inorganic materials 0.000 description 4
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 description 4
- 239000003921 oil Substances 0.000 description 4
- 235000019198 oils Nutrition 0.000 description 4
- 239000012466 permeate Substances 0.000 description 4
- 229920000058 polyacrylate Polymers 0.000 description 4
- 239000002994 raw material Substances 0.000 description 4
- 150000003505 terpenes Chemical class 0.000 description 4
- RSWGJHLUYNHPMX-UHFFFAOYSA-N Abietic-Saeure Natural products C12CCC(C(C)C)=CC2=CCC2C1(C)CCCC2(C)C(O)=O RSWGJHLUYNHPMX-UHFFFAOYSA-N 0.000 description 3
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 3
- LSNNMFCWUKXFEE-UHFFFAOYSA-M Bisulfite Chemical compound OS([O-])=O LSNNMFCWUKXFEE-UHFFFAOYSA-M 0.000 description 3
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 3
- KHPCPRHQVVSZAH-HUOMCSJISA-N Rosin Natural products O(C/C=C/c1ccccc1)[C@H]1[C@H](O)[C@@H](O)[C@@H](O)[C@@H](CO)O1 KHPCPRHQVVSZAH-HUOMCSJISA-N 0.000 description 3
- 239000006087 Silane Coupling Agent Substances 0.000 description 3
- 125000004432 carbon atom Chemical group C* 0.000 description 3
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 3
- 239000003792 electrolyte Substances 0.000 description 3
- 238000007757 hot melt coating Methods 0.000 description 3
- 239000003906 humectant Substances 0.000 description 3
- 150000002576 ketones Chemical class 0.000 description 3
- 229940057995 liquid paraffin Drugs 0.000 description 3
- 239000000203 mixture Substances 0.000 description 3
- 229940056211 paraffin Drugs 0.000 description 3
- 239000012188 paraffin wax Substances 0.000 description 3
- 239000003208 petroleum Substances 0.000 description 3
- 229920002742 polystyrene-block-poly(ethylene/propylene) -block-polystyrene Polymers 0.000 description 3
- 239000007787 solid Substances 0.000 description 3
- 229920000468 styrene butadiene styrene block copolymer Polymers 0.000 description 3
- 210000004243 sweat Anatomy 0.000 description 3
- KHPCPRHQVVSZAH-UHFFFAOYSA-N trans-cinnamyl beta-D-glucopyranoside Natural products OC1C(O)C(O)C(CO)OC1OCC=CC1=CC=CC=C1 KHPCPRHQVVSZAH-UHFFFAOYSA-N 0.000 description 3
- 239000006097 ultraviolet radiation absorber Substances 0.000 description 3
- PUPZLCDOIYMWBV-UHFFFAOYSA-N (+/-)-1,3-Butanediol Chemical compound CC(O)CCO PUPZLCDOIYMWBV-UHFFFAOYSA-N 0.000 description 2
- XDOFQFKRPWOURC-UHFFFAOYSA-N 16-methylheptadecanoic acid Chemical compound CC(C)CCCCCCCCCCCCCCC(O)=O XDOFQFKRPWOURC-UHFFFAOYSA-N 0.000 description 2
- NIXOWILDQLNWCW-UHFFFAOYSA-N 2-Propenoic acid Natural products OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 description 2
- WRMNZCZEMHIOCP-UHFFFAOYSA-N 2-phenylethanol Chemical compound OCCC1=CC=CC=C1 WRMNZCZEMHIOCP-UHFFFAOYSA-N 0.000 description 2
- KWOLFJPFCHCOCG-UHFFFAOYSA-N Acetophenone Chemical compound CC(=O)C1=CC=CC=C1 KWOLFJPFCHCOCG-UHFFFAOYSA-N 0.000 description 2
- VVJKKWFAADXIJK-UHFFFAOYSA-N Allylamine Chemical compound NCC=C VVJKKWFAADXIJK-UHFFFAOYSA-N 0.000 description 2
- ZTQSAGDEMFDKMZ-UHFFFAOYSA-N Butyraldehyde Chemical compound CCCC=O ZTQSAGDEMFDKMZ-UHFFFAOYSA-N 0.000 description 2
- XTEGARKTQYYJKE-UHFFFAOYSA-M Chlorate Chemical class [O-]Cl(=O)=O XTEGARKTQYYJKE-UHFFFAOYSA-M 0.000 description 2
- VZCYOOQTPOCHFL-OWOJBTEDSA-N Fumaric acid Chemical compound OC(=O)\C=C\C(O)=O VZCYOOQTPOCHFL-OWOJBTEDSA-N 0.000 description 2
- GLZPCOQZEFWAFX-UHFFFAOYSA-N Geraniol Chemical compound CC(C)=CCCC(C)=CCO GLZPCOQZEFWAFX-UHFFFAOYSA-N 0.000 description 2
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 2
- 101000873446 Homo sapiens Selenoprotein S Proteins 0.000 description 2
- 239000013032 Hydrocarbon resin Substances 0.000 description 2
- 206010061218 Inflammation Diseases 0.000 description 2
- AMIMRNSIRUDHCM-UHFFFAOYSA-N Isopropylaldehyde Chemical compound CC(C)C=O AMIMRNSIRUDHCM-UHFFFAOYSA-N 0.000 description 2
- YNAVUWVOSKDBBP-UHFFFAOYSA-N Morpholine Chemical compound C1COCCN1 YNAVUWVOSKDBBP-UHFFFAOYSA-N 0.000 description 2
- 239000004264 Petrolatum Substances 0.000 description 2
- XBDQKXXYIPTUBI-UHFFFAOYSA-M Propionate Chemical compound CCC([O-])=O XBDQKXXYIPTUBI-UHFFFAOYSA-M 0.000 description 2
- 102100034940 Selenoprotein S Human genes 0.000 description 2
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 2
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 description 2
- 239000002253 acid Substances 0.000 description 2
- 239000000654 additive Substances 0.000 description 2
- WNLRTRBMVRJNCN-UHFFFAOYSA-N adipic acid Chemical compound OC(=O)CCCCC(O)=O WNLRTRBMVRJNCN-UHFFFAOYSA-N 0.000 description 2
- 150000001413 amino acids Chemical class 0.000 description 2
- 150000003863 ammonium salts Chemical class 0.000 description 2
- HUMNYLRZRPPJDN-UHFFFAOYSA-N benzaldehyde Chemical compound O=CC1=CC=CC=C1 HUMNYLRZRPPJDN-UHFFFAOYSA-N 0.000 description 2
- WPYMKLBDIGXBTP-UHFFFAOYSA-N benzoic acid Chemical compound OC(=O)C1=CC=CC=C1 WPYMKLBDIGXBTP-UHFFFAOYSA-N 0.000 description 2
- QUKGYYKBILRGFE-UHFFFAOYSA-N benzyl acetate Chemical compound CC(=O)OCC1=CC=CC=C1 QUKGYYKBILRGFE-UHFFFAOYSA-N 0.000 description 2
- WGQKYBSKWIADBV-UHFFFAOYSA-N benzylamine Chemical compound NCC1=CC=CC=C1 WGQKYBSKWIADBV-UHFFFAOYSA-N 0.000 description 2
- GJKZSOHUVOQISW-UHFFFAOYSA-N buta-1,3-diene;2-methylbuta-1,3-diene;styrene Chemical compound C=CC=C.CC(=C)C=C.C=CC1=CC=CC=C1.C=CC1=CC=CC=C1 GJKZSOHUVOQISW-UHFFFAOYSA-N 0.000 description 2
- ULDHMXUKGWMISQ-UHFFFAOYSA-N carvone Chemical compound CC(=C)C1CC=C(C)C(=O)C1 ULDHMXUKGWMISQ-UHFFFAOYSA-N 0.000 description 2
- NEHNMFOYXAPHSD-UHFFFAOYSA-N citronellal Chemical compound O=CCC(C)CCC=C(C)C NEHNMFOYXAPHSD-UHFFFAOYSA-N 0.000 description 2
- QMVPMAAFGQKVCJ-UHFFFAOYSA-N citronellol Chemical compound OCCC(C)CCC=C(C)C QMVPMAAFGQKVCJ-UHFFFAOYSA-N 0.000 description 2
- 238000013329 compounding Methods 0.000 description 2
- 239000002781 deodorant agent Substances 0.000 description 2
- NOPFSRXAKWQILS-UHFFFAOYSA-N docosan-1-ol Chemical compound CCCCCCCCCCCCCCCCCCCCCCO NOPFSRXAKWQILS-UHFFFAOYSA-N 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 229920001971 elastomer Polymers 0.000 description 2
- 239000000806 elastomer Substances 0.000 description 2
- 239000003822 epoxy resin Substances 0.000 description 2
- 150000002148 esters Chemical class 0.000 description 2
- RRAFCDWBNXTKKO-UHFFFAOYSA-N eugenol Chemical compound COC1=CC(CC=C)=CC=C1O RRAFCDWBNXTKKO-UHFFFAOYSA-N 0.000 description 2
- 239000004088 foaming agent Substances 0.000 description 2
- 238000005227 gel permeation chromatography Methods 0.000 description 2
- JARKCYVAAOWBJS-UHFFFAOYSA-N hexanal Chemical compound CCCCCC=O JARKCYVAAOWBJS-UHFFFAOYSA-N 0.000 description 2
- 229920006270 hydrocarbon resin Polymers 0.000 description 2
- 239000012948 isocyanate Substances 0.000 description 2
- 150000002513 isocyanates Chemical class 0.000 description 2
- 239000004310 lactic acid Substances 0.000 description 2
- 235000014655 lactic acid Nutrition 0.000 description 2
- 239000004611 light stabiliser Substances 0.000 description 2
- XMGQYMWWDOXHJM-UHFFFAOYSA-N limonene Chemical compound CC(=C)C1CCC(C)=CC1 XMGQYMWWDOXHJM-UHFFFAOYSA-N 0.000 description 2
- CDOSHBSSFJOMGT-UHFFFAOYSA-N linalool Chemical compound CC(C)=CCCC(C)(O)C=C CDOSHBSSFJOMGT-UHFFFAOYSA-N 0.000 description 2
- 229910052751 metal Inorganic materials 0.000 description 2
- 239000002184 metal Substances 0.000 description 2
- QPJVMBTYPHYUOC-UHFFFAOYSA-N methyl benzoate Chemical compound COC(=O)C1=CC=CC=C1 QPJVMBTYPHYUOC-UHFFFAOYSA-N 0.000 description 2
- YLYBTZIQSIBWLI-UHFFFAOYSA-N octyl acetate Chemical compound CCCCCCCCOC(C)=O YLYBTZIQSIBWLI-UHFFFAOYSA-N 0.000 description 2
- 229940066842 petrolatum Drugs 0.000 description 2
- 235000019271 petrolatum Nutrition 0.000 description 2
- 239000005011 phenolic resin Substances 0.000 description 2
- 229920003023 plastic Polymers 0.000 description 2
- 239000004033 plastic Substances 0.000 description 2
- 229920006122 polyamide resin Polymers 0.000 description 2
- 229920000647 polyepoxide Polymers 0.000 description 2
- 229920002635 polyurethane Polymers 0.000 description 2
- 239000004814 polyurethane Substances 0.000 description 2
- 239000000047 product Substances 0.000 description 2
- 239000007921 spray Substances 0.000 description 2
- PRAKJMSDJKAYCZ-UHFFFAOYSA-N squalane Chemical compound CC(C)CCCC(C)CCCC(C)CCCCC(C)CCCC(C)CCCC(C)C PRAKJMSDJKAYCZ-UHFFFAOYSA-N 0.000 description 2
- 238000010025 steaming Methods 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- RUVINXPYWBROJD-ONEGZZNKSA-N trans-anethole Chemical compound COC1=CC=C(\C=C\C)C=C1 RUVINXPYWBROJD-ONEGZZNKSA-N 0.000 description 2
- HDTRYLNUVZCQOY-UHFFFAOYSA-N α-D-glucopyranosyl-α-D-glucopyranoside Natural products OC1C(O)C(O)C(CO)OC1OC1C(O)C(O)C(O)C(CO)O1 HDTRYLNUVZCQOY-UHFFFAOYSA-N 0.000 description 1
- NOOLISFMXDJSKH-UTLUCORTSA-N (+)-Neomenthol Chemical compound CC(C)[C@@H]1CC[C@@H](C)C[C@@H]1O NOOLISFMXDJSKH-UTLUCORTSA-N 0.000 description 1
- DTGKSKDOIYIVQL-WEDXCCLWSA-N (+)-borneol Chemical compound C1C[C@@]2(C)[C@@H](O)C[C@@H]1C2(C)C DTGKSKDOIYIVQL-WEDXCCLWSA-N 0.000 description 1
- NFLGAXVYCFJBMK-RKDXNWHRSA-N (+)-isomenthone Natural products CC(C)[C@H]1CC[C@@H](C)CC1=O NFLGAXVYCFJBMK-RKDXNWHRSA-N 0.000 description 1
- WMBWREPUVVBILR-WIYYLYMNSA-N (-)-Epigallocatechin-3-o-gallate Chemical compound O([C@@H]1CC2=C(O)C=C(C=C2O[C@@H]1C=1C=C(O)C(O)=C(O)C=1)O)C(=O)C1=CC(O)=C(O)C(O)=C1 WMBWREPUVVBILR-WIYYLYMNSA-N 0.000 description 1
- REPVLJRCJUVQFA-UHFFFAOYSA-N (-)-isopinocampheol Natural products C1C(O)C(C)C2C(C)(C)C1C2 REPVLJRCJUVQFA-UHFFFAOYSA-N 0.000 description 1
- XMAYWYJOQHXEEK-OZXSUGGESA-N (2R,4S)-ketoconazole Chemical compound C1CN(C(=O)C)CCN1C(C=C1)=CC=C1OC[C@@H]1O[C@@](CN2C=NC=C2)(C=2C(=CC(Cl)=CC=2)Cl)OC1 XMAYWYJOQHXEEK-OZXSUGGESA-N 0.000 description 1
- MQHLMHIZUIDKOO-OKZBNKHCSA-N (2R,6S)-2,6-dimethyl-4-[(2S)-2-methyl-3-[4-(2-methylbutan-2-yl)phenyl]propyl]morpholine Chemical compound C1=CC(C(C)(C)CC)=CC=C1C[C@H](C)CN1C[C@@H](C)O[C@@H](C)C1 MQHLMHIZUIDKOO-OKZBNKHCSA-N 0.000 description 1
- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 description 1
- WLAUCMCTKPXDIY-JXMROGBWSA-N (2e)-1-chloro-3,7-dimethylocta-2,6-diene Chemical compound CC(C)=CCC\C(C)=C\CCl WLAUCMCTKPXDIY-JXMROGBWSA-N 0.000 description 1
- SDOFMBGMRVAJNF-KVTDHHQDSA-N (2r,3r,4r,5r)-6-aminohexane-1,2,3,4,5-pentol Chemical compound NC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO SDOFMBGMRVAJNF-KVTDHHQDSA-N 0.000 description 1
- WYTZZXDRDKSJID-UHFFFAOYSA-N (3-aminopropyl)triethoxysilane Chemical compound CCO[Si](OCC)(OCC)CCCN WYTZZXDRDKSJID-UHFFFAOYSA-N 0.000 description 1
- 239000001490 (3R)-3,7-dimethylocta-1,6-dien-3-ol Substances 0.000 description 1
- WRIDQFICGBMAFQ-UHFFFAOYSA-N (E)-8-Octadecenoic acid Natural products CCCCCCCCCC=CCCCCCCC(O)=O WRIDQFICGBMAFQ-UHFFFAOYSA-N 0.000 description 1
- KJPRLNWUNMBNBZ-QPJJXVBHSA-N (E)-cinnamaldehyde Chemical compound O=C\C=C\C1=CC=CC=C1 KJPRLNWUNMBNBZ-QPJJXVBHSA-N 0.000 description 1
- QMVPMAAFGQKVCJ-SNVBAGLBSA-N (R)-(+)-citronellol Natural products OCC[C@H](C)CCC=C(C)C QMVPMAAFGQKVCJ-SNVBAGLBSA-N 0.000 description 1
- DSSYKIVIOFKYAU-XCBNKYQSSA-N (R)-camphor Chemical compound C1C[C@@]2(C)C(=O)C[C@@H]1C2(C)C DSSYKIVIOFKYAU-XCBNKYQSSA-N 0.000 description 1
- CDOSHBSSFJOMGT-JTQLQIEISA-N (R)-linalool Natural products CC(C)=CCC[C@@](C)(O)C=C CDOSHBSSFJOMGT-JTQLQIEISA-N 0.000 description 1
- ZXHDVRATSGZISC-UHFFFAOYSA-N 1,2-bis(ethenoxy)ethane Chemical compound C=COCCOC=C ZXHDVRATSGZISC-UHFFFAOYSA-N 0.000 description 1
- 229940058015 1,3-butylene glycol Drugs 0.000 description 1
- AFNXATANNDIXLG-SFHVURJKSA-N 1-[(2r)-2-[(4-chlorophenyl)methylsulfanyl]-2-(2,4-dichlorophenyl)ethyl]imidazole Chemical compound C1=CC(Cl)=CC=C1CS[C@H](C=1C(=CC(Cl)=CC=1)Cl)CN1C=NC=C1 AFNXATANNDIXLG-SFHVURJKSA-N 0.000 description 1
- OCAPBUJLXMYKEJ-UHFFFAOYSA-N 1-[biphenyl-4-yl(phenyl)methyl]imidazole Chemical compound C1=NC=CN1C(C=1C=CC(=CC=1)C=1C=CC=CC=1)C1=CC=CC=C1 OCAPBUJLXMYKEJ-UHFFFAOYSA-N 0.000 description 1
- IXPNQXFRVYWDDI-UHFFFAOYSA-N 1-methyl-2,4-dioxo-1,3-diazinane-5-carboximidamide Chemical compound CN1CC(C(N)=N)C(=O)NC1=O IXPNQXFRVYWDDI-UHFFFAOYSA-N 0.000 description 1
- HFZLSTDPRQSZCQ-UHFFFAOYSA-N 1-pyrrolidin-3-ylpyrrolidine Chemical compound C1CCCN1C1CNCC1 HFZLSTDPRQSZCQ-UHFFFAOYSA-N 0.000 description 1
- BQMPGKPTOHKYHS-UHFFFAOYSA-N 1h-pyrrole-2-carbonitrile Chemical compound N#CC1=CC=CN1 BQMPGKPTOHKYHS-UHFFFAOYSA-N 0.000 description 1
- GXURZKWLMYOCDX-UHFFFAOYSA-N 2,2-bis(hydroxymethyl)propane-1,3-diol;dihydroxyphosphanyl dihydrogen phosphite Chemical compound OP(O)OP(O)O.OCC(CO)(CO)CO GXURZKWLMYOCDX-UHFFFAOYSA-N 0.000 description 1
- COPFWAGBXIWZNK-UHFFFAOYSA-N 2,3-bis(6-methylheptanoyloxy)propyl 6-methylheptanoate Chemical compound CC(C)CCCCC(=O)OCC(OC(=O)CCCCC(C)C)COC(=O)CCCCC(C)C COPFWAGBXIWZNK-UHFFFAOYSA-N 0.000 description 1
- GJDRKHHGPHLVNI-UHFFFAOYSA-N 2,6-ditert-butyl-4-(diethoxyphosphorylmethyl)phenol Chemical compound CCOP(=O)(OCC)CC1=CC(C(C)(C)C)=C(O)C(C(C)(C)C)=C1 GJDRKHHGPHLVNI-UHFFFAOYSA-N 0.000 description 1
- SMZOUWXMTYCWNB-UHFFFAOYSA-N 2-(2-methoxy-5-methylphenyl)ethanamine Chemical compound COC1=CC=C(C)C=C1CCN SMZOUWXMTYCWNB-UHFFFAOYSA-N 0.000 description 1
- FLPJVCMIKUWSDR-UHFFFAOYSA-N 2-(4-formylphenoxy)acetamide Chemical compound NC(=O)COC1=CC=C(C=O)C=C1 FLPJVCMIKUWSDR-UHFFFAOYSA-N 0.000 description 1
- LVYLCBNXHHHPSB-UHFFFAOYSA-N 2-hydroxyethyl salicylate Chemical compound OCCOC(=O)C1=CC=CC=C1O LVYLCBNXHHHPSB-UHFFFAOYSA-N 0.000 description 1
- GAODDBNJCKQQDY-UHFFFAOYSA-N 2-methyl-4,6-bis(octylsulfanylmethyl)phenol Chemical compound CCCCCCCCSCC1=CC(C)=C(O)C(CSCCCCCCCC)=C1 GAODDBNJCKQQDY-UHFFFAOYSA-N 0.000 description 1
- GASMGDMKGYYAHY-UHFFFAOYSA-N 2-methylidenehexanamide Chemical group CCCCC(=C)C(N)=O GASMGDMKGYYAHY-UHFFFAOYSA-N 0.000 description 1
- LEACJMVNYZDSKR-UHFFFAOYSA-N 2-octyldodecan-1-ol Chemical compound CCCCCCCCCCC(CO)CCCCCCCC LEACJMVNYZDSKR-UHFFFAOYSA-N 0.000 description 1
- BGRXBNZMPMGLQI-UHFFFAOYSA-N 2-octyldodecyl tetradecanoate Chemical compound CCCCCCCCCCCCCC(=O)OCC(CCCCCCCC)CCCCCCCCCC BGRXBNZMPMGLQI-UHFFFAOYSA-N 0.000 description 1
- LQJBNNIYVWPHFW-UHFFFAOYSA-N 20:1omega9c fatty acid Natural products CCCCCCCCCCC=CCCCCCCCC(O)=O LQJBNNIYVWPHFW-UHFFFAOYSA-N 0.000 description 1
- GOLORTLGFDVFDW-UHFFFAOYSA-N 3-(1h-benzimidazol-2-yl)-7-(diethylamino)chromen-2-one Chemical compound C1=CC=C2NC(C3=CC4=CC=C(C=C4OC3=O)N(CC)CC)=NC2=C1 GOLORTLGFDVFDW-UHFFFAOYSA-N 0.000 description 1
- ZYAASQNKCWTPKI-UHFFFAOYSA-N 3-[dimethoxy(methyl)silyl]propan-1-amine Chemical compound CO[Si](C)(OC)CCCN ZYAASQNKCWTPKI-UHFFFAOYSA-N 0.000 description 1
- IKYAJDOSWUATPI-UHFFFAOYSA-N 3-[dimethoxy(methyl)silyl]propane-1-thiol Chemical compound CO[Si](C)(OC)CCCS IKYAJDOSWUATPI-UHFFFAOYSA-N 0.000 description 1
- LZMNXXQIQIHFGC-UHFFFAOYSA-N 3-[dimethoxy(methyl)silyl]propyl 2-methylprop-2-enoate Chemical compound CO[Si](C)(OC)CCCOC(=O)C(C)=C LZMNXXQIQIHFGC-UHFFFAOYSA-N 0.000 description 1
- DCQBZYNUSLHVJC-UHFFFAOYSA-N 3-triethoxysilylpropane-1-thiol Chemical compound CCO[Si](OCC)(OCC)CCCS DCQBZYNUSLHVJC-UHFFFAOYSA-N 0.000 description 1
- SJECZPVISLOESU-UHFFFAOYSA-N 3-trimethoxysilylpropan-1-amine Chemical compound CO[Si](OC)(OC)CCCN SJECZPVISLOESU-UHFFFAOYSA-N 0.000 description 1
- XDLMVUHYZWKMMD-UHFFFAOYSA-N 3-trimethoxysilylpropyl 2-methylprop-2-enoate Chemical compound CO[Si](OC)(OC)CCCOC(=O)C(C)=C XDLMVUHYZWKMMD-UHFFFAOYSA-N 0.000 description 1
- MSHFRERJPWKJFX-UHFFFAOYSA-N 4-Methoxybenzyl alcohol Chemical compound COC1=CC=C(CO)C=C1 MSHFRERJPWKJFX-UHFFFAOYSA-N 0.000 description 1
- HBTAOSGHCXUEKI-UHFFFAOYSA-N 4-chloro-n,n-dimethyl-3-nitrobenzenesulfonamide Chemical compound CN(C)S(=O)(=O)C1=CC=C(Cl)C([N+]([O-])=O)=C1 HBTAOSGHCXUEKI-UHFFFAOYSA-N 0.000 description 1
- HIQIXEFWDLTDED-UHFFFAOYSA-N 4-hydroxy-1-piperidin-4-ylpyrrolidin-2-one Chemical compound O=C1CC(O)CN1C1CCNCC1 HIQIXEFWDLTDED-UHFFFAOYSA-N 0.000 description 1
- SQDAZGGFXASXDW-UHFFFAOYSA-N 5-bromo-2-(trifluoromethoxy)pyridine Chemical compound FC(F)(F)OC1=CC=C(Br)C=N1 SQDAZGGFXASXDW-UHFFFAOYSA-N 0.000 description 1
- ODHCTXKNWHHXJC-VKHMYHEASA-N 5-oxo-L-proline Chemical compound OC(=O)[C@@H]1CCC(=O)N1 ODHCTXKNWHHXJC-VKHMYHEASA-N 0.000 description 1
- QSBYPNXLFMSGKH-UHFFFAOYSA-N 9-Heptadecensaeure Natural products CCCCCCCC=CCCCCCCCC(O)=O QSBYPNXLFMSGKH-UHFFFAOYSA-N 0.000 description 1
- 241001116389 Aloe Species 0.000 description 1
- 239000005711 Benzoic acid Substances 0.000 description 1
- 239000004215 Carbon black (E152) Substances 0.000 description 1
- 239000005973 Carvone Substances 0.000 description 1
- 108010076119 Caseins Proteins 0.000 description 1
- NPBVQXIMTZKSBA-UHFFFAOYSA-N Chavibetol Natural products COC1=CC=C(CC=C)C=C1O NPBVQXIMTZKSBA-UHFFFAOYSA-N 0.000 description 1
- 229920002101 Chitin Polymers 0.000 description 1
- 229920001661 Chitosan Polymers 0.000 description 1
- 229920001287 Chondroitin sulfate Polymers 0.000 description 1
- 241000723346 Cinnamomum camphora Species 0.000 description 1
- WTEVQBCEXWBHNA-UHFFFAOYSA-N Citral Natural products CC(C)=CCCC(C)=CC=O WTEVQBCEXWBHNA-UHFFFAOYSA-N 0.000 description 1
- 102000008186 Collagen Human genes 0.000 description 1
- 108010035532 Collagen Proteins 0.000 description 1
- WHPAGCJNPTUGGD-UHFFFAOYSA-N Croconazole Chemical compound ClC1=CC=CC(COC=2C(=CC=CC=2)C(=C)N2C=NC=C2)=C1 WHPAGCJNPTUGGD-UHFFFAOYSA-N 0.000 description 1
- NOOLISFMXDJSKH-UHFFFAOYSA-N DL-menthol Natural products CC(C)C1CCC(C)CC1O NOOLISFMXDJSKH-UHFFFAOYSA-N 0.000 description 1
- FEWJPZIEWOKRBE-JCYAYHJZSA-N Dextrotartaric acid Chemical compound OC(=O)[C@H](O)[C@@H](O)C(O)=O FEWJPZIEWOKRBE-JCYAYHJZSA-N 0.000 description 1
- 102100029721 DnaJ homolog subfamily B member 1 Human genes 0.000 description 1
- 102000016942 Elastin Human genes 0.000 description 1
- 108010014258 Elastin Proteins 0.000 description 1
- JOYRKODLDBILNP-UHFFFAOYSA-N Ethyl urethane Chemical compound CCOC(N)=O JOYRKODLDBILNP-UHFFFAOYSA-N 0.000 description 1
- FPVVYTCTZKCSOJ-UHFFFAOYSA-N Ethylene glycol distearate Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCCOC(=O)CCCCCCCCCCCCCCCCC FPVVYTCTZKCSOJ-UHFFFAOYSA-N 0.000 description 1
- 229920000181 Ethylene propylene rubber Polymers 0.000 description 1
- WEEGYLXZBRQIMU-UHFFFAOYSA-N Eucalyptol Chemical compound C1CC2CCC1(C)OC2(C)C WEEGYLXZBRQIMU-UHFFFAOYSA-N 0.000 description 1
- 244000004281 Eucalyptus maculata Species 0.000 description 1
- 239000005770 Eugenol Substances 0.000 description 1
- 208000010201 Exanthema Diseases 0.000 description 1
- 108010010803 Gelatin Proteins 0.000 description 1
- 239000005792 Geraniol Substances 0.000 description 1
- GLZPCOQZEFWAFX-YFHOEESVSA-N Geraniol Natural products CC(C)=CCC\C(C)=C/CO GLZPCOQZEFWAFX-YFHOEESVSA-N 0.000 description 1
- HTTJABKRGRZYRN-UHFFFAOYSA-N Heparin Chemical compound OC1C(NC(=O)C)C(O)OC(COS(O)(=O)=O)C1OC1C(OS(O)(=O)=O)C(O)C(OC2C(C(OS(O)(=O)=O)C(OC3C(C(O)C(O)C(O3)C(O)=O)OS(O)(=O)=O)C(CO)O2)NS(O)(=O)=O)C(C(O)=O)O1 HTTJABKRGRZYRN-UHFFFAOYSA-N 0.000 description 1
- 101000866018 Homo sapiens DnaJ homolog subfamily B member 1 Proteins 0.000 description 1
- 108010076876 Keratins Proteins 0.000 description 1
- 102000011782 Keratins Human genes 0.000 description 1
- NFLGAXVYCFJBMK-UHFFFAOYSA-N Menthone Chemical compound CC(C)C1CCC(C)CC1=O NFLGAXVYCFJBMK-UHFFFAOYSA-N 0.000 description 1
- BYBLEWFAAKGYCD-UHFFFAOYSA-N Miconazole Chemical compound ClC1=CC(Cl)=CC=C1COC(C=1C(=CC(Cl)=CC=1)Cl)CN1C=NC=C1 BYBLEWFAAKGYCD-UHFFFAOYSA-N 0.000 description 1
- 241000772415 Neovison vison Species 0.000 description 1
- 239000005642 Oleic acid Substances 0.000 description 1
- ZQPPMHVWECSIRJ-UHFFFAOYSA-N Oleic acid Natural products CCCCCCCCC=CCCCCCCCC(O)=O ZQPPMHVWECSIRJ-UHFFFAOYSA-N 0.000 description 1
- 240000007594 Oryza sativa Species 0.000 description 1
- 235000007164 Oryza sativa Nutrition 0.000 description 1
- 229910019142 PO4 Inorganic materials 0.000 description 1
- OQILCOQZDHPEAZ-UHFFFAOYSA-N Palmitinsaeure-octylester Natural products CCCCCCCCCCCCCCCC(=O)OCCCCCCCC OQILCOQZDHPEAZ-UHFFFAOYSA-N 0.000 description 1
- JKIJEFPNVSHHEI-UHFFFAOYSA-N Phenol, 2,4-bis(1,1-dimethylethyl)-, phosphite (3:1) Chemical compound CC(C)(C)C1=CC(C(C)(C)C)=CC=C1OP(OC=1C(=CC(=CC=1)C(C)(C)C)C(C)(C)C)OC1=CC=C(C(C)(C)C)C=C1C(C)(C)C JKIJEFPNVSHHEI-UHFFFAOYSA-N 0.000 description 1
- OAICVXFJPJFONN-UHFFFAOYSA-N Phosphorus Chemical compound [P] OAICVXFJPJFONN-UHFFFAOYSA-N 0.000 description 1
- 229920002845 Poly(methacrylic acid) Polymers 0.000 description 1
- 239000004698 Polyethylene Substances 0.000 description 1
- UVMRYBDEERADNV-UHFFFAOYSA-N Pseudoeugenol Natural products COC1=CC(C(C)=C)=CC=C1O UVMRYBDEERADNV-UHFFFAOYSA-N 0.000 description 1
- LCTONWCANYUPML-UHFFFAOYSA-M Pyruvate Chemical compound CC(=O)C([O-])=O LCTONWCANYUPML-UHFFFAOYSA-M 0.000 description 1
- VBCURLVXJUEZHX-UHFFFAOYSA-N SCCCCO[Si](OC)(OC)CCCC Chemical compound SCCCCO[Si](OC)(OC)CCCC VBCURLVXJUEZHX-UHFFFAOYSA-N 0.000 description 1
- BHOXZWGVSHABIR-UHFFFAOYSA-N SCCC[Si](OC)(OC)OC.NCCNCCC[Si](OC)(OC)C Chemical compound SCCC[Si](OC)(OC)OC.NCCNCCC[Si](OC)(OC)C BHOXZWGVSHABIR-UHFFFAOYSA-N 0.000 description 1
- 101150106604 SIS2 gene Proteins 0.000 description 1
- UGGAILYEBCSZIV-ITJSPEIASA-N Siccanin Chemical compound C1CCC(C)(C)[C@@H]2CC[C@]3(C)OC4=CC(C)=CC(O)=C4[C@H]4[C@@H]3[C@@]21CO4 UGGAILYEBCSZIV-ITJSPEIASA-N 0.000 description 1
- UGGAILYEBCSZIV-UHFFFAOYSA-N Siccanin Natural products C1CCC(C)(C)C2CCC3(C)OC4=CC(C)=CC(O)=C4C4C3C21CO4 UGGAILYEBCSZIV-UHFFFAOYSA-N 0.000 description 1
- 244000044822 Simmondsia californica Species 0.000 description 1
- 235000004433 Simmondsia californica Nutrition 0.000 description 1
- 239000004902 Softening Agent Substances 0.000 description 1
- 229920002125 Sokalan® Polymers 0.000 description 1
- 108010073771 Soybean Proteins Proteins 0.000 description 1
- 229920002472 Starch Polymers 0.000 description 1
- 235000021355 Stearic acid Nutrition 0.000 description 1
- KDYFGRWQOYBRFD-UHFFFAOYSA-N Succinic acid Natural products OC(=O)CCC(O)=O KDYFGRWQOYBRFD-UHFFFAOYSA-N 0.000 description 1
- FEWJPZIEWOKRBE-UHFFFAOYSA-N Tartaric acid Natural products [H+].[H+].[O-]C(=O)C(O)C(O)C([O-])=O FEWJPZIEWOKRBE-UHFFFAOYSA-N 0.000 description 1
- HDTRYLNUVZCQOY-WSWWMNSNSA-N Trehalose Natural products O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@@H](O)[C@@H](CO)O1 HDTRYLNUVZCQOY-WSWWMNSNSA-N 0.000 description 1
- 235000021307 Triticum Nutrition 0.000 description 1
- 244000098338 Triticum aestivum Species 0.000 description 1
- AXMVYSVVTMKQSL-UHFFFAOYSA-N UNPD142122 Natural products OC1=CC=C(C=CC=O)C=C1O AXMVYSVVTMKQSL-UHFFFAOYSA-N 0.000 description 1
- ZYPGADGCNXOUJP-CXVPHVKISA-N Variotin Chemical compound CCCC[C@@H](O)\C=C(/C)\C=C\C=C\C(=O)N1CCCC1=O ZYPGADGCNXOUJP-CXVPHVKISA-N 0.000 description 1
- BGYHLZZASRKEJE-UHFFFAOYSA-N [3-[3-(3,5-ditert-butyl-4-hydroxyphenyl)propanoyloxy]-2,2-bis[3-(3,5-ditert-butyl-4-hydroxyphenyl)propanoyloxymethyl]propyl] 3-(3,5-ditert-butyl-4-hydroxyphenyl)propanoate Chemical compound CC(C)(C)C1=C(O)C(C(C)(C)C)=CC(CCC(=O)OCC(COC(=O)CCC=2C=C(C(O)=C(C=2)C(C)(C)C)C(C)(C)C)(COC(=O)CCC=2C=C(C(O)=C(C=2)C(C)(C)C)C(C)(C)C)COC(=O)CCC=2C=C(C(O)=C(C=2)C(C)(C)C)C(C)(C)C)=C1 BGYHLZZASRKEJE-UHFFFAOYSA-N 0.000 description 1
- 235000011054 acetic acid Nutrition 0.000 description 1
- 230000000996 additive effect Effects 0.000 description 1
- 239000002313 adhesive film Substances 0.000 description 1
- 238000007718 adhesive strength test Methods 0.000 description 1
- 239000001361 adipic acid Substances 0.000 description 1
- 235000011037 adipic acid Nutrition 0.000 description 1
- 229910052783 alkali metal Inorganic materials 0.000 description 1
- 229910001508 alkali metal halide Inorganic materials 0.000 description 1
- 150000008045 alkali metal halides Chemical class 0.000 description 1
- 229910001615 alkaline earth metal halide Inorganic materials 0.000 description 1
- 235000011399 aloe vera Nutrition 0.000 description 1
- HDTRYLNUVZCQOY-LIZSDCNHSA-N alpha,alpha-trehalose Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 HDTRYLNUVZCQOY-LIZSDCNHSA-N 0.000 description 1
- 229960003204 amorolfine Drugs 0.000 description 1
- 229940011037 anethole Drugs 0.000 description 1
- 229940088710 antibiotic agent Drugs 0.000 description 1
- BTFJIXJJCSYFAL-UHFFFAOYSA-N arachidyl alcohol Natural products CCCCCCCCCCCCCCCCCCCCO BTFJIXJJCSYFAL-UHFFFAOYSA-N 0.000 description 1
- 125000003118 aryl group Chemical group 0.000 description 1
- 239000002585 base Substances 0.000 description 1
- 235000013871 bee wax Nutrition 0.000 description 1
- 239000012166 beeswax Substances 0.000 description 1
- 235000010233 benzoic acid Nutrition 0.000 description 1
- 150000008366 benzophenones Chemical class 0.000 description 1
- 125000003354 benzotriazolyl group Chemical class N1N=NC2=C1C=CC=C2* 0.000 description 1
- 229940007550 benzyl acetate Drugs 0.000 description 1
- JGQFVRIQXUFPAH-UHFFFAOYSA-N beta-citronellol Natural products OCCC(C)CCCC(C)=C JGQFVRIQXUFPAH-UHFFFAOYSA-N 0.000 description 1
- 229960002206 bifonazole Drugs 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 230000000740 bleeding effect Effects 0.000 description 1
- CKDOCTFBFTVPSN-UHFFFAOYSA-N borneol Natural products C1CC2(C)C(C)CC1C2(C)C CKDOCTFBFTVPSN-UHFFFAOYSA-N 0.000 description 1
- 229940116229 borneol Drugs 0.000 description 1
- FACXGONDLDSNOE-UHFFFAOYSA-N buta-1,3-diene;styrene Chemical compound C=CC=C.C=CC1=CC=CC=C1.C=CC1=CC=CC=C1 FACXGONDLDSNOE-UHFFFAOYSA-N 0.000 description 1
- 235000019437 butane-1,3-diol Nutrition 0.000 description 1
- KDYFGRWQOYBRFD-NUQCWPJISA-N butanedioic acid Chemical compound O[14C](=O)CC[14C](O)=O KDYFGRWQOYBRFD-NUQCWPJISA-N 0.000 description 1
- ABJKWBDEJIDSJZ-UHFFFAOYSA-N butenafine Chemical compound C=1C=CC2=CC=CC=C2C=1CN(C)CC1=CC=C(C(C)(C)C)C=C1 ABJKWBDEJIDSJZ-UHFFFAOYSA-N 0.000 description 1
- 229960002962 butenafine Drugs 0.000 description 1
- 239000011575 calcium Substances 0.000 description 1
- 229910052791 calcium Inorganic materials 0.000 description 1
- 239000010495 camellia oil Substances 0.000 description 1
- 229930008380 camphor Natural products 0.000 description 1
- 229960000846 camphor Drugs 0.000 description 1
- 239000004202 carbamide Substances 0.000 description 1
- GNVMUORYQLCPJZ-UHFFFAOYSA-N carbamothioic s-acid Chemical compound NC(S)=O GNVMUORYQLCPJZ-UHFFFAOYSA-N 0.000 description 1
- 150000007942 carboxylates Chemical class 0.000 description 1
- 239000004203 carnauba wax Substances 0.000 description 1
- 235000013869 carnauba wax Nutrition 0.000 description 1
- 239000005018 casein Substances 0.000 description 1
- BECPQYXYKAMYBN-UHFFFAOYSA-N casein, tech. Chemical compound NCCCCC(C(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(CC(C)C)N=C(O)C(CCC(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(C(C)O)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(COP(O)(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(N)CC1=CC=CC=C1 BECPQYXYKAMYBN-UHFFFAOYSA-N 0.000 description 1
- 235000021240 caseins Nutrition 0.000 description 1
- 239000001913 cellulose Substances 0.000 description 1
- 229920002678 cellulose Polymers 0.000 description 1
- 229940106189 ceramide Drugs 0.000 description 1
- 150000001783 ceramides Chemical class 0.000 description 1
- 229940081733 cetearyl alcohol Drugs 0.000 description 1
- 229960000541 cetyl alcohol Drugs 0.000 description 1
- 229940074979 cetyl palmitate Drugs 0.000 description 1
- 150000001840 cholesterol esters Chemical class 0.000 description 1
- 229940059329 chondroitin sulfate Drugs 0.000 description 1
- 229930007050 cineol Natural products 0.000 description 1
- 229960005233 cineole Drugs 0.000 description 1
- KJPRLNWUNMBNBZ-UHFFFAOYSA-N cinnamic aldehyde Natural products O=CC=CC1=CC=CC=C1 KJPRLNWUNMBNBZ-UHFFFAOYSA-N 0.000 description 1
- 229940117916 cinnamic aldehyde Drugs 0.000 description 1
- WJSDHUCWMSHDCR-VMPITWQZSA-N cinnamyl acetate Natural products CC(=O)OC\C=C\C1=CC=CC=C1 WJSDHUCWMSHDCR-VMPITWQZSA-N 0.000 description 1
- 229940043350 citral Drugs 0.000 description 1
- 229930003633 citronellal Natural products 0.000 description 1
- 235000000983 citronellal Nutrition 0.000 description 1
- 235000000484 citronellol Nutrition 0.000 description 1
- 229960004022 clotrimazole Drugs 0.000 description 1
- VNFPBHJOKIVQEB-UHFFFAOYSA-N clotrimazole Chemical compound ClC1=CC=CC=C1C(N1C=NC=C1)(C=1C=CC=CC=1)C1=CC=CC=C1 VNFPBHJOKIVQEB-UHFFFAOYSA-N 0.000 description 1
- 229920001436 collagen Polymers 0.000 description 1
- 239000002285 corn oil Substances 0.000 description 1
- 235000005687 corn oil Nutrition 0.000 description 1
- 229960002042 croconazole Drugs 0.000 description 1
- DNTGGZPQPQTDQF-XBXARRHUSA-N crotamiton Chemical compound C/C=C/C(=O)N(CC)C1=CC=CC=C1C DNTGGZPQPQTDQF-XBXARRHUSA-N 0.000 description 1
- 229960003338 crotamiton Drugs 0.000 description 1
- 230000001877 deodorizing effect Effects 0.000 description 1
- 239000007933 dermal patch Substances 0.000 description 1
- OTARVPUIYXHRRB-UHFFFAOYSA-N diethoxy-methyl-[3-(oxiran-2-ylmethoxy)propyl]silane Chemical compound CCO[Si](C)(OCC)CCCOCC1CO1 OTARVPUIYXHRRB-UHFFFAOYSA-N 0.000 description 1
- 229940031578 diisopropyl adipate Drugs 0.000 description 1
- WHGNXNCOTZPEEK-UHFFFAOYSA-N dimethoxy-methyl-[3-(oxiran-2-ylmethoxy)propyl]silane Chemical compound CO[Si](C)(OC)CCCOCC1CO1 WHGNXNCOTZPEEK-UHFFFAOYSA-N 0.000 description 1
- SZXQTJUDPRGNJN-UHFFFAOYSA-N dipropylene glycol Chemical compound OCCCOCCCO SZXQTJUDPRGNJN-UHFFFAOYSA-N 0.000 description 1
- ZYPGADGCNXOUJP-UHFFFAOYSA-N dl-Variotin Natural products CCCCC(O)C=C(C)C=CC=CC(=O)N1CCCC1=O ZYPGADGCNXOUJP-UHFFFAOYSA-N 0.000 description 1
- DTGKSKDOIYIVQL-UHFFFAOYSA-N dl-isoborneol Natural products C1CC2(C)C(O)CC1C2(C)C DTGKSKDOIYIVQL-UHFFFAOYSA-N 0.000 description 1
- 229960000735 docosanol Drugs 0.000 description 1
- GMSCBRSQMRDRCD-UHFFFAOYSA-N dodecyl 2-methylprop-2-enoate Chemical compound CCCCCCCCCCCCOC(=O)C(C)=C GMSCBRSQMRDRCD-UHFFFAOYSA-N 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 229920002549 elastin Polymers 0.000 description 1
- FWDBOZPQNFPOLF-UHFFFAOYSA-N ethenyl(triethoxy)silane Chemical compound CCO[Si](OCC)(OCC)C=C FWDBOZPQNFPOLF-UHFFFAOYSA-N 0.000 description 1
- NKSJNEHGWDZZQF-UHFFFAOYSA-N ethenyl(trimethoxy)silane Chemical compound CO[Si](OC)(OC)C=C NKSJNEHGWDZZQF-UHFFFAOYSA-N 0.000 description 1
- GJQLBGWSDGMZKM-UHFFFAOYSA-N ethylhexyl palmitate Chemical compound CCCCCCCCCCCCCCCC(=O)OC(CC)CCCCC GJQLBGWSDGMZKM-UHFFFAOYSA-N 0.000 description 1
- 229960002217 eugenol Drugs 0.000 description 1
- 238000011156 evaluation Methods 0.000 description 1
- 201000005884 exanthem Diseases 0.000 description 1
- 238000011049 filling Methods 0.000 description 1
- 239000000796 flavoring agent Substances 0.000 description 1
- 235000019634 flavors Nutrition 0.000 description 1
- 239000001530 fumaric acid Substances 0.000 description 1
- 239000008273 gelatin Substances 0.000 description 1
- 229920000159 gelatin Polymers 0.000 description 1
- 235000019322 gelatine Nutrition 0.000 description 1
- 235000011852 gelatine desserts Nutrition 0.000 description 1
- WTEVQBCEXWBHNA-JXMROGBWSA-N geranial Chemical compound CC(C)=CCC\C(C)=C\C=O WTEVQBCEXWBHNA-JXMROGBWSA-N 0.000 description 1
- 229940113087 geraniol Drugs 0.000 description 1
- 150000004676 glycans Chemical class 0.000 description 1
- 235000011187 glycerol Nutrition 0.000 description 1
- 229940100608 glycol distearate Drugs 0.000 description 1
- 229960002389 glycol salicylate Drugs 0.000 description 1
- 229920000578 graft copolymer Polymers 0.000 description 1
- LNEPOXFFQSENCJ-UHFFFAOYSA-N haloperidol Chemical compound C1CC(O)(C=2C=CC(Cl)=CC=2)CCN1CCCC(=O)C1=CC=C(F)C=C1 LNEPOXFFQSENCJ-UHFFFAOYSA-N 0.000 description 1
- 229920000669 heparin Polymers 0.000 description 1
- 229960002897 heparin Drugs 0.000 description 1
- BXWNKGSJHAJOGX-UHFFFAOYSA-N hexadecan-1-ol Chemical compound CCCCCCCCCCCCCCCCO BXWNKGSJHAJOGX-UHFFFAOYSA-N 0.000 description 1
- SFFVATKALSIZGN-UHFFFAOYSA-N hexadecan-7-ol Chemical compound CCCCCCCCCC(O)CCCCCC SFFVATKALSIZGN-UHFFFAOYSA-N 0.000 description 1
- PXDJXZJSCPSGGI-UHFFFAOYSA-N hexadecanoic acid hexadecyl ester Natural products CCCCCCCCCCCCCCCCOC(=O)CCCCCCCCCCCCCCC PXDJXZJSCPSGGI-UHFFFAOYSA-N 0.000 description 1
- XJNUECKWDBNFJV-UHFFFAOYSA-N hexadecyl 2-ethylhexanoate Chemical compound CCCCCCCCCCCCCCCCOC(=O)C(CC)CCCC XJNUECKWDBNFJV-UHFFFAOYSA-N 0.000 description 1
- 235000012907 honey Nutrition 0.000 description 1
- 238000007731 hot pressing Methods 0.000 description 1
- 229920002674 hyaluronan Polymers 0.000 description 1
- 229960003160 hyaluronic acid Drugs 0.000 description 1
- 229930195733 hydrocarbon Natural products 0.000 description 1
- 150000002430 hydrocarbons Chemical class 0.000 description 1
- WQYVRQLZKVEZGA-UHFFFAOYSA-N hypochlorite Chemical class Cl[O-] WQYVRQLZKVEZGA-UHFFFAOYSA-N 0.000 description 1
- 150000002460 imidazoles Chemical class 0.000 description 1
- 150000002466 imines Chemical class 0.000 description 1
- 230000004054 inflammatory process Effects 0.000 description 1
- 239000003112 inhibitor Substances 0.000 description 1
- 229910052500 inorganic mineral Inorganic materials 0.000 description 1
- 229930002839 ionone Natural products 0.000 description 1
- 150000002499 ionone derivatives Chemical class 0.000 description 1
- 230000001788 irregular Effects 0.000 description 1
- QXJSBBXBKPUZAA-UHFFFAOYSA-N isooleic acid Natural products CCCCCCCC=CCCCCCCCCC(O)=O QXJSBBXBKPUZAA-UHFFFAOYSA-N 0.000 description 1
- 229940074928 isopropyl myristate Drugs 0.000 description 1
- XUGNVMKQXJXZCD-UHFFFAOYSA-N isopropyl palmitate Chemical compound CCCCCCCCCCCCCCCC(=O)OC(C)C XUGNVMKQXJXZCD-UHFFFAOYSA-N 0.000 description 1
- 229960004125 ketoconazole Drugs 0.000 description 1
- 150000002596 lactones Chemical class 0.000 description 1
- 235000001510 limonene Nutrition 0.000 description 1
- 229940087305 limonene Drugs 0.000 description 1
- 229930007744 linalool Natural products 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 239000011777 magnesium Substances 0.000 description 1
- 229910052749 magnesium Inorganic materials 0.000 description 1
- 239000000845 maltitol Substances 0.000 description 1
- 235000010449 maltitol Nutrition 0.000 description 1
- VQHSOMBJVWLPSR-WUJBLJFYSA-N maltitol Chemical compound OC[C@H](O)[C@@H](O)[C@@H]([C@H](O)CO)O[C@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O VQHSOMBJVWLPSR-WUJBLJFYSA-N 0.000 description 1
- 229940035436 maltitol Drugs 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 150000004667 medium chain fatty acids Chemical class 0.000 description 1
- 239000000155 melt Substances 0.000 description 1
- 238000002844 melting Methods 0.000 description 1
- 230000008018 melting Effects 0.000 description 1
- 229940041616 menthol Drugs 0.000 description 1
- 229930007503 menthone Natural products 0.000 description 1
- 229910001507 metal halide Inorganic materials 0.000 description 1
- 150000005309 metal halides Chemical class 0.000 description 1
- 150000002739 metals Chemical class 0.000 description 1
- 229940095102 methyl benzoate Drugs 0.000 description 1
- 229960002509 miconazole Drugs 0.000 description 1
- 239000011707 mineral Substances 0.000 description 1
- 230000003020 moisturizing effect Effects 0.000 description 1
- 239000000178 monomer Substances 0.000 description 1
- PHQOGHDTIVQXHL-UHFFFAOYSA-N n'-(3-trimethoxysilylpropyl)ethane-1,2-diamine Chemical compound CO[Si](OC)(OC)CCCNCCN PHQOGHDTIVQXHL-UHFFFAOYSA-N 0.000 description 1
- JXTPJDDICSTXJX-UHFFFAOYSA-N n-Triacontane Natural products CCCCCCCCCCCCCCCCCCCCCCCCCCCCCC JXTPJDDICSTXJX-UHFFFAOYSA-N 0.000 description 1
- VWOIKFDZQQLJBJ-DTQAZKPQSA-N neticonazole Chemical compound CCCCCOC1=CC=CC=C1\C(=C/SC)N1C=NC=C1 VWOIKFDZQQLJBJ-DTQAZKPQSA-N 0.000 description 1
- 229950010757 neticonazole Drugs 0.000 description 1
- 150000002823 nitrates Chemical class 0.000 description 1
- 229960000988 nystatin Drugs 0.000 description 1
- VQOXZBDYSJBXMA-NQTDYLQESA-N nystatin A1 Chemical compound O[C@H]1[C@@H](N)[C@H](O)[C@@H](C)O[C@H]1O[C@H]1/C=C/C=C/C=C/C=C/CC/C=C/C=C/[C@H](C)[C@@H](O)[C@@H](C)[C@H](C)OC(=O)C[C@H](O)C[C@H](O)C[C@H](O)CC[C@@H](O)[C@H](O)C[C@](O)(C[C@H](O)[C@H]2C(O)=O)O[C@H]2C1 VQOXZBDYSJBXMA-NQTDYLQESA-N 0.000 description 1
- GLDOVTGHNKAZLK-UHFFFAOYSA-N octadecan-1-ol Chemical compound CCCCCCCCCCCCCCCCCCO GLDOVTGHNKAZLK-UHFFFAOYSA-N 0.000 description 1
- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 description 1
- OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 description 1
- KSCKTBJJRVPGKM-UHFFFAOYSA-N octan-1-olate;titanium(4+) Chemical compound [Ti+4].CCCCCCCC[O-].CCCCCCCC[O-].CCCCCCCC[O-].CCCCCCCC[O-] KSCKTBJJRVPGKM-UHFFFAOYSA-N 0.000 description 1
- 229940073665 octyldodecyl myristate Drugs 0.000 description 1
- 229940060184 oil ingredients Drugs 0.000 description 1
- ZQPPMHVWECSIRJ-KTKRTIGZSA-N oleic acid Chemical compound CCCCCCCC\C=C/CCCCCCCC(O)=O ZQPPMHVWECSIRJ-KTKRTIGZSA-N 0.000 description 1
- 235000021313 oleic acid Nutrition 0.000 description 1
- 239000004006 olive oil Substances 0.000 description 1
- 235000008390 olive oil Nutrition 0.000 description 1
- JMFOSJNGKJCTMJ-ZHZULCJRSA-N omoconazole Chemical compound C1=CN=CN1C(/C)=C(C=1C(=CC(Cl)=CC=1)Cl)\OCCOC1=CC=C(Cl)C=C1 JMFOSJNGKJCTMJ-ZHZULCJRSA-N 0.000 description 1
- 229960004031 omoconazole Drugs 0.000 description 1
- 230000003287 optical effect Effects 0.000 description 1
- 229960003483 oxiconazole Drugs 0.000 description 1
- QRJJEGAJXVEBNE-MOHJPFBDSA-N oxiconazole Chemical compound ClC1=CC(Cl)=CC=C1CO\N=C(C=1C(=CC(Cl)=CC=1)Cl)\CN1C=NC=C1 QRJJEGAJXVEBNE-MOHJPFBDSA-N 0.000 description 1
- QNGNSVIICDLXHT-UHFFFAOYSA-N para-ethylbenzaldehyde Natural products CCC1=CC=C(C=O)C=C1 QNGNSVIICDLXHT-UHFFFAOYSA-N 0.000 description 1
- RUVINXPYWBROJD-UHFFFAOYSA-N para-methoxyphenyl Natural products COC1=CC=C(C=CC)C=C1 RUVINXPYWBROJD-UHFFFAOYSA-N 0.000 description 1
- 235000010987 pectin Nutrition 0.000 description 1
- 239000001814 pectin Substances 0.000 description 1
- 229920001277 pectin Polymers 0.000 description 1
- VLTRZXGMWDSKGL-UHFFFAOYSA-N perchloric acid Chemical class OCl(=O)(=O)=O VLTRZXGMWDSKGL-UHFFFAOYSA-N 0.000 description 1
- 150000002989 phenols Chemical class 0.000 description 1
- WVDDGKGOMKODPV-ZQBYOMGUSA-N phenyl(114C)methanol Chemical compound O[14CH2]C1=CC=CC=C1 WVDDGKGOMKODPV-ZQBYOMGUSA-N 0.000 description 1
- 235000021317 phosphate Nutrition 0.000 description 1
- 150000003013 phosphoric acid derivatives Chemical class 0.000 description 1
- 239000011574 phosphorus Substances 0.000 description 1
- 229910052698 phosphorus Inorganic materials 0.000 description 1
- 229920000083 poly(allylamine) Polymers 0.000 description 1
- 239000004584 polyacrylic acid Substances 0.000 description 1
- 229920000728 polyester Polymers 0.000 description 1
- 229920000573 polyethylene Polymers 0.000 description 1
- 229920000642 polymer Polymers 0.000 description 1
- 239000005518 polymer electrolyte Substances 0.000 description 1
- 229920000098 polyolefin Polymers 0.000 description 1
- 229920001282 polysaccharide Polymers 0.000 description 1
- 239000005017 polysaccharide Substances 0.000 description 1
- 229920002743 polystyrene-poly(ethylene-ethylene/propylene) block-polystyrene Polymers 0.000 description 1
- 239000011591 potassium Substances 0.000 description 1
- 229910052700 potassium Inorganic materials 0.000 description 1
- 238000003825 pressing Methods 0.000 description 1
- 102000004196 processed proteins & peptides Human genes 0.000 description 1
- 108090000765 processed proteins & peptides Proteins 0.000 description 1
- 235000018102 proteins Nutrition 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 229940079889 pyrrolidonecarboxylic acid Drugs 0.000 description 1
- 206010037844 rash Diseases 0.000 description 1
- 230000003252 repetitive effect Effects 0.000 description 1
- 230000000717 retained effect Effects 0.000 description 1
- 235000009566 rice Nutrition 0.000 description 1
- YGSDEFSMJLZEOE-UHFFFAOYSA-N salicylic acid Chemical class OC(=O)C1=CC=CC=C1O YGSDEFSMJLZEOE-UHFFFAOYSA-N 0.000 description 1
- 239000013535 sea water Substances 0.000 description 1
- 229950008379 siccanin Drugs 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 239000000661 sodium alginate Substances 0.000 description 1
- 235000010413 sodium alginate Nutrition 0.000 description 1
- 229940005550 sodium alginate Drugs 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 229940001941 soy protein Drugs 0.000 description 1
- 229940032094 squalane Drugs 0.000 description 1
- 229910001220 stainless steel Inorganic materials 0.000 description 1
- 239000010935 stainless steel Substances 0.000 description 1
- 239000008107 starch Substances 0.000 description 1
- 235000019698 starch Nutrition 0.000 description 1
- 239000008117 stearic acid Substances 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 150000003440 styrenes Chemical class 0.000 description 1
- 229920006249 styrenic copolymer Polymers 0.000 description 1
- 150000005846 sugar alcohols Polymers 0.000 description 1
- 229960002607 sulconazole Drugs 0.000 description 1
- 150000003467 sulfuric acid derivatives Chemical class 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
- 229920003051 synthetic elastomer Polymers 0.000 description 1
- 239000005061 synthetic rubber Substances 0.000 description 1
- 239000011975 tartaric acid Substances 0.000 description 1
- 235000002906 tartaric acid Nutrition 0.000 description 1
- 229960002722 terbinafine Drugs 0.000 description 1
- DOMXUEMWDBAQBQ-WEVVVXLNSA-N terbinafine Chemical compound C1=CC=C2C(CN(C\C=C\C#CC(C)(C)C)C)=CC=CC2=C1 DOMXUEMWDBAQBQ-WEVVVXLNSA-N 0.000 description 1
- 229960004880 tolnaftate Drugs 0.000 description 1
- FUSNMLFNXJSCDI-UHFFFAOYSA-N tolnaftate Chemical compound C=1C=C2C=CC=CC2=CC=1OC(=S)N(C)C1=CC=CC(C)=C1 FUSNMLFNXJSCDI-UHFFFAOYSA-N 0.000 description 1
- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 description 1
- JXUKBNICSRJFAP-UHFFFAOYSA-N triethoxy-[3-(oxiran-2-ylmethoxy)propyl]silane Chemical compound CCO[Si](OCC)(OCC)CCCOCC1CO1 JXUKBNICSRJFAP-UHFFFAOYSA-N 0.000 description 1
- UFTFJSFQGQCHQW-UHFFFAOYSA-N triformin Chemical compound O=COCC(OC=O)COC=O UFTFJSFQGQCHQW-UHFFFAOYSA-N 0.000 description 1
- DQZNLOXENNXVAD-UHFFFAOYSA-N trimethoxy-[2-(7-oxabicyclo[4.1.0]heptan-4-yl)ethyl]silane Chemical compound C1C(CC[Si](OC)(OC)OC)CCC2OC21 DQZNLOXENNXVAD-UHFFFAOYSA-N 0.000 description 1
- BPSIOYPQMFLKFR-UHFFFAOYSA-N trimethoxy-[3-(oxiran-2-ylmethoxy)propyl]silane Chemical compound CO[Si](OC)(OC)CCCOCC1CO1 BPSIOYPQMFLKFR-UHFFFAOYSA-N 0.000 description 1
- 210000002700 urine Anatomy 0.000 description 1
- HGBOYTHUEUWSSQ-UHFFFAOYSA-N valeric aldehyde Natural products CCCCC=O HGBOYTHUEUWSSQ-UHFFFAOYSA-N 0.000 description 1
- 235000015112 vegetable and seed oil Nutrition 0.000 description 1
- 229920002554 vinyl polymer Polymers 0.000 description 1
- 230000002087 whitening effect Effects 0.000 description 1
- 229940105125 zinc myristate Drugs 0.000 description 1
- GAWWVVGZMLGEIW-GNNYBVKZSA-L zinc ricinoleate Chemical compound [Zn+2].CCCCCC[C@@H](O)C\C=C/CCCCCCCC([O-])=O.CCCCCC[C@@H](O)C\C=C/CCCCCCCC([O-])=O GAWWVVGZMLGEIW-GNNYBVKZSA-L 0.000 description 1
- 229940100530 zinc ricinoleate Drugs 0.000 description 1
- IFNXAMCERSVZCV-UHFFFAOYSA-L zinc;2-ethylhexanoate Chemical compound [Zn+2].CCCCC(CC)C([O-])=O.CCCCC(CC)C([O-])=O IFNXAMCERSVZCV-UHFFFAOYSA-L 0.000 description 1
- GBFLQPIIIRJQLU-UHFFFAOYSA-L zinc;tetradecanoate Chemical compound [Zn+2].CCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCC([O-])=O GBFLQPIIIRJQLU-UHFFFAOYSA-L 0.000 description 1
Images
Abstract
Description
本発明は、皮膚に貼り付ける用途の粘着シートに関する。 The present invention relates to a pressure-sensitive adhesive sheet for use on a skin.
絆創膏、サージカルテープ、心電図測定用の電極固定用シート等のように、医療分野で
使用される粘着シートには、その粘着性の高さからアクリル系重合体が一般的に使用されている。しかし、アクリル系重合体は合成後に未反応のモノマーが残留し易く、アクリル系重合体を使用した粘着シートを、皮膚に貼付すると発疹等の炎症の原因となる場合がある。
そのため、炎症の原因物質を含まないホットメルト粘着剤を使用した粘着シートが使用される場合が多い。
しかし、ホットメルト粘着剤を使用した粘着シートは、粘着剤層に透湿性が無いため、皮膚に貼付して長時間が経過すると、汗が粘着剤層を透過できず滞留して、皮膚の蒸れやかゆみの原因になっていた。
Acrylic polymers are generally used for adhesive sheets used in the medical field, such as adhesive bandages, surgical tapes, and electrode fixing sheets for electrocardiogram measurement, because of their high adhesiveness. However, unreacted monomers tend to remain after the synthesis of the acrylic polymer, and if an adhesive sheet using the acrylic polymer is applied to the skin, it may cause inflammation such as a rash.
For this reason, an adhesive sheet using a hot-melt adhesive that does not contain inflammation-causing substances is often used.
However, the pressure-sensitive adhesive sheet using hot-melt pressure-sensitive adhesive does not have moisture permeability in the pressure-sensitive adhesive layer, so that after a long time has passed since it was applied to the skin, sweat cannot permeate the pressure-sensitive adhesive layer and stay in the skin. It was a cause of itching.
そこで、特許文献１および特許文献２には、ホットメルト粘着剤の透湿性確保を目的として一定パターンの開口部を有する粘着剤層を用いた粘着シートが開示されている。
In view of this,
しかし、従来の粘着シートは、粘着剤層の開口部には透湿性があったが、非開口部には透湿性が無いため、粘着剤層の非開口部と接する皮膚に蒸れやかゆみが発生する問題があった。 However, conventional pressure-sensitive adhesive sheets have moisture permeability in the opening of the pressure-sensitive adhesive layer, but the non-opening is not moisture-permeable, so stuffiness and itching occur on the skin in contact with the non-opening of the pressure-sensitive adhesive layer. There was a problem to do.
本発明は、皮膚に長時間貼付した場合に蒸れやかゆみが生じ難い、皮膚貼付用粘着シートおよびその製造方法の提供を目的とする。 An object of the present invention is to provide a pressure-sensitive adhesive sheet for skin application and a method for producing the same, which are less likely to cause stuffiness or itching when applied to the skin for a long time.
本発明の皮膚貼付用粘着シートは、通気性フォーム体、およびホットメルト粘着剤層（Ａ）を備え、前記ホットメルト粘着剤層（Ａ）は、表面の空隙率が５〜５０％であり、１平方ミリメートル当たりに円相当径が１０〜４００μｍの孔を２個以上有する。 The pressure-sensitive adhesive sheet for skin application of the present invention comprises a breathable foam body and a hot-melt pressure-sensitive adhesive layer (A), and the hot-melt pressure-sensitive adhesive layer (A) has a surface porosity of 5 to 50%, Two or more holes having an equivalent circle diameter of 10 to 400 μm per square millimeter are provided.
上記の本発明によれば、ホットメルト粘着剤層（Ａ）は、一定面積当たり所定の貫通孔を有することで適度な表面空隙率を有する。そのため、汗等の水分が粘着剤層を通過し、さらに通気性フォーム体を通じて放出されやすくなることで、皮膚の蒸れやかゆみを抑制できる。 According to the present invention described above, the hot melt pressure-sensitive adhesive layer (A) has an appropriate surface porosity by having predetermined through holes per certain area. Therefore, moisture such as sweat passes through the pressure-sensitive adhesive layer, and is easily released through the breathable foam body, so that it is possible to suppress skin stuffiness and itching.
本発明により皮膚に長時間貼付した場合に蒸れやかゆみが生じ難い、皮膚貼付用粘着シートおよびその製造方法を提供できる。 According to the present invention, it is possible to provide a pressure-sensitive adhesive sheet for skin application and a method for producing the same, which are less likely to cause stuffiness or itching when applied to the skin for a long time.
本発明の皮膚貼付用粘着シート（以下、単に「粘着シート」という）は、通気性フォーム体、およびホットメルト粘着剤層（Ａ）を備え、前記ホットメルト粘着剤層（Ａ）は、表面の空隙率が５〜５０％であり、１平方ミリメートル当たりに円相当径が１０〜４００μｍの孔を２個以上有する。なお、本明細書で粘着シート、粘着テープおよび粘着フィルムは同義語である。 The pressure-sensitive adhesive sheet for skin application of the present invention (hereinafter simply referred to as “pressure-sensitive adhesive sheet”) includes a breathable foam body and a hot-melt pressure-sensitive adhesive layer (A), and the hot-melt pressure-sensitive adhesive layer (A) The porosity is 5 to 50%, and there are two or more holes having a circle equivalent diameter of 10 to 400 μm per square millimeter. In addition, in this specification, an adhesive sheet, an adhesive tape, and an adhesive film are synonymous.
本発明の粘着シートは、もともと皮膚を刺激し難い成分で構成されたホットメルト粘着剤を用いた粘着シートである。後述するが一定の透湿性を有するホットメルト粘着剤層（Ａ）の塗工形状は、いわゆるベタ塗りの粘着剤層、開口部を有するパターン状の粘着剤層、あるいは、点状ないし島状のように粘着剤層が連続しないパターンの粘着剤層であっても良い。 The pressure-sensitive adhesive sheet of the present invention is a pressure-sensitive adhesive sheet that uses a hot-melt pressure-sensitive adhesive originally composed of components that are difficult to irritate the skin. As will be described later, the coating shape of the hot-melt pressure-sensitive adhesive layer (A) having a certain moisture permeability is a so-called solid pressure-sensitive adhesive layer, a patterned pressure-sensitive adhesive layer having an opening, or a dot-like or island-like shape. Thus, the pressure-sensitive adhesive layer may have a pattern in which the pressure-sensitive adhesive layer is not continuous.
本発明の粘着シートは、皮膚に直接使用する用途が好ましい。 The adhesive sheet of the present invention is preferably used directly on the skin.
＜通気性フォーム体＞
本発明で用いる通気性フォーム体は、汗等の水分（水ないし水蒸気）を透過できる連続気泡ないし貫通孔を有している。そのため通気性フォーム体は、ホットメルト粘着剤層（Ａ）を通過（ないし透過）した水分を通過できる程度の連続気泡を有すればよいため特に限定されないところ、その水蒸気透過性を挙げるとすれば３０００ｇ／ｍ２・２４時間以上である。水蒸気透過性は、通気性フォーム体が粘着シートとして使用できる強度を有する範囲内であれば高ければ高いほど好ましいため特に上限値はないところ、強いて挙げれば１００００ｇ／ｍ２・２４時間程度である。なお、水蒸気透過性は、ＪＩＳ―Ｚ０２０８に準じた方法で測定された数値である。なお連続気泡とは、例えば、通気性フォーム体を製造する際に使用した発泡剤に起因して生じた気泡であるが、発泡剤を用いて作製されたものに限定されないことはいうまでもない。なお、本明細書で孔は、貫通孔を意味する。
<Breathable foam body>
The breathable foam used in the present invention has open cells or through-holes that can permeate moisture such as sweat (water or water vapor). Therefore, the breathable foam body is not particularly limited because it has only to have open cells that can pass the water that has passed (or passed through) the hot melt pressure-sensitive adhesive layer (A). It is 3000 g / m 2 · 24 hours or more. The water vapor permeability is preferably as high as possible as long as the breathable foam body has a strength that can be used as a pressure-sensitive adhesive sheet. Therefore, there is no particular upper limit, but if it is mentioned, it is about 10,000 g / m 2 · 24 hours. The water vapor permeability is a numerical value measured by a method according to JIS-Z0208. Note that the open cells are, for example, bubbles generated due to the foaming agent used in producing the breathable foam body, but it is needless to say that the open cells are not limited to those produced using the foaming agent. . In addition, in this specification, a hole means a through hole.
通気性フォーム体の素材は、粘着シートとして使用可能な柔軟性および通気性を有する公知の素材であればよく限定されない。前記素材は、プラスチックス、合成ゴムが好ましい。素材は、例えば、ポリウレタン、ポリエステル、ポリオレフィン、エチレンプロピレンゴム等が挙げられる。 The material of the breathable foam body is not limited as long as it is a known material having flexibility and breathability that can be used as an adhesive sheet. The material is preferably plastics or synthetic rubber. Examples of the material include polyurethane, polyester, polyolefin, ethylene propylene rubber, and the like.
通気性フォーム体の厚みは、通常０．０５ｍｍ〜１０ｍｍ程度であり、０．５ｍｍ〜５ｍｍが好ましい。 The thickness of the breathable foam body is usually about 0.05 mm to 10 mm, preferably 0.5 mm to 5 mm.
＜ホットメルト粘着剤＞
ホットメルト粘着剤層（Ａ）は、ホットメルト粘着剤を塗工することで形成する。
ホットメルト粘着剤は、例えばスチレン系共重合体、粘着付与剤、軟化剤を含むことが好ましい。
<Hot melt adhesive>
The hot melt pressure-sensitive adhesive layer (A) is formed by applying a hot melt pressure-sensitive adhesive.
The hot melt adhesive preferably contains, for example, a styrene copolymer, a tackifier, and a softener.
スチレン系共重合体は、ホットメルト粘着剤層（Ａ）に凝集力を付与する主成分であり、公知のスチレンブロック共重合体を用いることが好ましい。
スチレン系共重合体は、例えばスチレン−エチレン−ブチレン−スチレンブロック共重合体（以下、「ＳＥＢＳ」とも略記する）、スチレン−イソプレン−スチレンブロック共重合物（以下、「ＳＩＳ」とも略記する）、スチレン−イソプレン−スチレンブロック共重合物の水素添加物（以下、「ＳＥＰＳ」とも略記する）、スチレン−ブタジエン−スチレンブロック共重合物（以下、「ＳＢＳ」とも略記する） 、スチレン−ブタジエン−スチレンブロック共重合物の水素添加物（以下、「ＳＥＢＳ」とも略記する）、スチレン−ブタジエン−イソプレン−スチレンブロック共重合物（以下、「ＳＢＩＳ」とも略記する）、スチレン−ブタジエン−イソプレン−スチレンブロック共重合物の水素添加物（以下、「ＳＥＥＰＳ」とも略記する）等が挙げられる。スチレン系共重合体は、単独または２種類以上を併用できる。
The styrene-based copolymer is a main component that imparts cohesive force to the hot melt pressure-sensitive adhesive layer (A), and it is preferable to use a known styrene block copolymer.
Examples of the styrene copolymer include a styrene-ethylene-butylene-styrene block copolymer (hereinafter abbreviated as “SEBS”), a styrene-isoprene-styrene block copolymer (hereinafter abbreviated as “SIS”), Hydrogenated product of styrene-isoprene-styrene block copolymer (hereinafter also abbreviated as “SEPS”), styrene-butadiene-styrene block copolymer (hereinafter abbreviated as “SBS”), styrene-butadiene-styrene block Hydrogenated copolymer (hereinafter also abbreviated as “SEBS”), styrene-butadiene-isoprene-styrene block copolymer (hereinafter also abbreviated as “SBIS”), styrene-butadiene-isoprene-styrene block copolymer Hydrogenated product (hereinafter also abbreviated as “SEEPS”) Etc. Styrenic copolymers can be used alone or in combination of two or more.
スチレン系共重合体は、メルトフローレイト（ＭＦＲ）が０．５ｇ／１０分以上１００ｇ／１０分（１９０℃、２．１６ｋｇ）以下であることが好ましい。ＭＦＲを前記範囲内にあることで塗工適性がより向上する。なおＭＦＲとは溶液状態にある樹脂の流動性を示す指標であり、ＪＩＳ Ｋ７２１０に準拠して測定したものである。 The styrene copolymer preferably has a melt flow rate (MFR) of 0.5 g / 10 min or more and 100 g / 10 min (190 ° C., 2.16 kg) or less. When the MFR is within the above range, the coating suitability is further improved. MFR is an index indicating the fluidity of a resin in a solution state, and is measured according to JIS K7210.
スチレン系共重合体の配合量は、ホットメルト粘着剤１００重量％のうち、３〜６５重量％が好ましく、２５〜３５重量％がより好ましい。配合量が前記範囲内にあると凝集力とホットメルト粘着剤の製造し易さを両立し易い。 The blending amount of the styrene copolymer is preferably 3 to 65% by weight, more preferably 25 to 35% by weight, out of 100% by weight of the hot melt adhesive. When the blending amount is within the above range, it is easy to achieve both cohesion and ease of manufacturing a hot melt pressure-sensitive adhesive.
粘着付与剤は、ホットメルト粘着剤層（Ａ）に粘着力を付与できる公知の化合物である。粘着付与剤は、その軟化点が８０〜１６０℃であることが好ましい。軟化点が前記範囲内にあることで凝集力と粘着力を両立し易い。なお、本発明で軟化点とは、JISK６８６３に規定される方法により求められる温度である。すなわち、ホットメルト粘着剤を充填した規定の環を１２時間以上静置させた後、熱媒体中に入れて規定の球を、ホットメルト粘着剤を充填した規定の環の上に置き、一定の割合で熱媒体の温度を上昇させたとき、ホットメルト粘着剤の軟化により球が沈み環台の底板に触れたときの温度である。 A tackifier is a well-known compound which can provide adhesive force to a hot-melt-adhesive layer (A). The tackifier preferably has a softening point of 80 to 160 ° C. When the softening point is within the above range, it is easy to achieve both cohesion and adhesion. In the present invention, the softening point is a temperature determined by a method defined in JISK6863. That is, after leaving the specified ring filled with the hot-melt pressure-sensitive adhesive to stand for 12 hours or more, it is placed in a heat medium and the specified sphere is placed on the specified ring filled with the hot-melt pressure-sensitive adhesive. When the temperature of the heat medium is increased by a ratio, the temperature is when the sphere sinks due to softening of the hot melt adhesive and touches the bottom plate of the ring platform.
粘着付与剤は、例えばロジン系樹脂、水素添加されたロジン系樹脂、テルペン系樹脂、水素添加されたテルペン系樹脂、炭化水素系樹脂、水素添加された炭化水素系樹脂、エポキシ系樹脂、水素添加されたエポキシ系樹脂、ポリアミド系樹脂、水素添加されたポリアミド系樹脂、エラストマー系樹脂、水素添加されたエラストマー系樹脂、フェノール系樹脂、水素添加されたフェノール系樹脂、ケトン系樹脂、水素添加されたケトン系樹脂、石油径樹脂、水素添加された石油径樹脂、スチレン系樹脂および水素添加されたスチレン系樹脂などが挙げられる。これらの中でも色相の観点から水素添加されたテルペン系樹脂がより好ましい。粘着付与剤は、単独または２種以上併用できる。 Tackifiers include, for example, rosin resins, hydrogenated rosin resins, terpene resins, hydrogenated terpene resins, hydrocarbon resins, hydrogenated hydrocarbon resins, epoxy resins, hydrogenated Epoxy resin, polyamide resin, hydrogenated polyamide resin, elastomer resin, hydrogenated elastomer resin, phenol resin, hydrogenated phenol resin, ketone resin, hydrogenated Examples thereof include ketone resins, petroleum diameter resins, hydrogenated petroleum diameter resins, styrene resins, and hydrogenated styrene resins. Among these, hydrogenated terpene resins are more preferable from the viewpoint of hue. The tackifiers can be used alone or in combination of two or more.
粘着付与剤の配合量は、ホットメルト粘着剤１００重量％のうち、３〜６０重量％が好ましく、２０〜３５重量％がより好ましい。配合量が前記範囲内にあると粘着力と凝集力を高いレベルで両立しやすくなる。 The amount of the tackifier is preferably 3 to 60% by weight, more preferably 20 to 35% by weight, out of 100% by weight of the hot melt pressure-sensitive adhesive. When the blending amount is within the above range, it becomes easy to achieve both adhesive strength and cohesive strength at a high level.
軟化剤は、ホットメルト粘着剤を加熱塗工する際に、ホットメルト粘着剤の粘度を塗工に適する粘度に下げる機能を有する。 The softening agent has a function of reducing the viscosity of the hot melt pressure-sensitive adhesive to a viscosity suitable for coating when the hot melt pressure-sensitive adhesive is applied by heating.
軟化剤は、その分子量が１００〜１００００であることが好ましい。分子量が前記範囲内にあるとホットメルト粘着剤を塗工するために加熱する際の粘度が低下し易い一方、ブリードアウトがより生じ難くなる。本発明で分子量は、単一化合物の場合は化学式量、混合物の場合は重量平均分子量である。また、本発明で重量平均分子量は、ゲルパーミエーションクロマトグラフィー法（以下、「ＧＰＣ」とも略記する）によるポリスチレン換算された重量平均分子量である。 The softener preferably has a molecular weight of 100 to 10,000. When the molecular weight is within the above range, the viscosity at the time of heating to coat the hot melt pressure-sensitive adhesive is likely to decrease, but bleeding out is more difficult to occur. In the present invention, the molecular weight is a chemical formula weight in the case of a single compound, and a weight average molecular weight in the case of a mixture. In the present invention, the weight average molecular weight is a polystyrene-converted weight average molecular weight obtained by gel permeation chromatography (hereinafter also abbreviated as “GPC”).
軟化剤は、ホットメルト粘着剤に使用できる公知の軟化剤が使用できるところ、例えば例えば流動パラフィン、パラフィン、スクワラン、ミスチル酸、ミスチル酸イソプロピル、ミスチル酸亜鉛、ミリスチン酸オクチルドデシル、トリイソオクタン酸グリセリン、オクチルドデカノール、ヘキシルデカノール、アジピン酸ジイソプロピル、セバシン酸ジエチル、ステアリン酸、イソステアリン酸、クロタミトン、中鎖脂肪酸トリグリセリト、サリチル酸エチレングリコール、エチルヘキサン酸セチル、オレイン酸、オリーブ油、カルナウバロウ、米胚芽油、コーン油、サザンカ油、ジステアリン酸グリコール、セテアリルアルコール、セタノール、ツバキ油、パルミチン酸セチル、パルミチン酸エチルヘキシル、パルミチン酸イソプロピル、ヒマシ油、ベヘニルアルコール、ホホバ種子油、ミンク油、ワセリン、ミツロウ、ユーカリ葉油、はちみつ、パラフィン鎖炭素数が全炭素数の５０％以上を占めるパラフィン系鉱物油、ナフテン環炭素数が全炭素数の３０〜４０重量％を占めるナフテン系鉱物油、および芳香族炭素数が全炭素数の３０重量％以上を占める芳香族系鉱物油などが挙げられる。これらの中でも粘着テープの生産性の面から流動パラフィン、パラフィン鎖炭素数が全炭素数の５０％以上を占めるパラフィン系鉱物油がより好ましい。軟化剤は、単独または２種類以上を併用できる。 As the softener, known softeners that can be used for hot melt adhesives can be used.For example, liquid paraffin, paraffin, squalane, misty acid, isopropyl myristate, zinc myristate, octyldodecyl myristate, glycerin triisooctanoate, Octyldodecanol, hexyldecanol, diisopropyl adipate, diethyl sebacate, stearic acid, isostearic acid, crotamiton, medium chain fatty acid triglyceride, ethylene glycol salicylate, cetyl ethylhexanoate, oleic acid, olive oil, carnauba wax, rice germ oil, corn oil, Sasanqua oil, glycol distearate, cetearyl alcohol, cetanol, camellia oil, cetyl palmitate, ethylhexyl palmitate, isopropyl palmitate, Masi oil, behenyl alcohol, jojoba seed oil, mink oil, petrolatum, beeswax, eucalyptus leaf oil, honey, paraffinic mineral oil with paraffin chain carbon number accounting for 50% or more of the total carbon number, naphthenic ring carbon number of total carbon number Examples thereof include naphthenic mineral oil occupying 30 to 40% by weight, and aromatic mineral oil occupying 30% by weight or more of the total number of carbon atoms. Among these, liquid paraffin and paraffinic mineral oil in which the number of carbon atoms in the paraffin chain accounts for 50% or more of the total number of carbon atoms are more preferable from the viewpoint of productivity of the adhesive tape. The softeners can be used alone or in combination of two or more.
軟化剤の配合量は、ホットメルト粘着剤１００重量％のうち、２０〜６０重量％が好ましく、３０〜５０重量％がより好ましい。配合量が前記範囲内にあることで加工性と凝集力をより高いレベルで両立しやすくなる。 The blending amount of the softener is preferably 20 to 60% by weight, more preferably 30 to 50% by weight, out of 100% by weight of the hot melt pressure-sensitive adhesive. When the blending amount is in the above range, it becomes easy to achieve both workability and cohesion at a higher level.
ホットメルト粘着剤は、さらに以下の添加剤を配合できる。例えば酸化防止剤、紫外線吸収剤、光安定剤、接着昂進防止剤、シランカップリング剤、抗菌剤、消臭剤、香料、保湿剤、吸水剤、電解質塩が挙げられる。 The hot melt pressure-sensitive adhesive can further contain the following additives. For example, antioxidants, ultraviolet absorbers, light stabilizers, adhesion progress inhibitors, silane coupling agents, antibacterial agents, deodorants, fragrances, humectants, water absorbing agents, and electrolyte salts can be mentioned.
酸化防止剤は、例えばフェノール系酸化防止剤およびリン系酸化防止剤が好ましい。
酸化防止剤は、例えばペンタエリスリトールテトラキス［３−（３，５−ジ−ｔ−ブチル−４−ヒドロキシフェニル）プロピオネート］、オクタデシル−３−（３，５−ジ−ｔ−ブチル−４−ヒドロキシフェニル）プロピオネート、ジエチル〔［３，５−ビス（１，１−ジメチルエチル）−４−ヒドロキシフェニル］メチル〕ホスフォネート、４，６−ビス（オクチルチオメチル）−ｏ−クレゾール、エチレンビス（オキシエチレン）ビス［３−（５−ｔ−ブチル−４−ヒドロキシ−ｍ−トリル］プロピオネート、トリス（２，４−ジ−ｔ−ブチルフェニル）フォスファイト、ビス（２，４−ジ−ｔ−ブチルフェニル）ペンタエリスリトールジフォスファイト等が挙げられる。酸化防止剤は、単独または２種類以上を併用できる。
As the antioxidant, for example, a phenol-based antioxidant and a phosphorus-based antioxidant are preferable.
Examples of the antioxidant include pentaerythritol tetrakis [3- (3,5-di-t-butyl-4-hydroxyphenyl) propionate], octadecyl-3- (3,5-di-t-butyl-4-hydroxyphenyl). ) Propionate, diethyl [[3,5-bis (1,1-dimethylethyl) -4-hydroxyphenyl] methyl] phosphonate, 4,6-bis (octylthiomethyl) -o-cresol, ethylenebis (oxyethylene) Bis [3- (5-t-butyl-4-hydroxy-m-tolyl] propionate, tris (2,4-di-t-butylphenyl) phosphite, bis (2,4-di-t-butylphenyl) Examples thereof include pentaerythritol diphosphite, etc. The antioxidants can be used alone or in combination of two or more.
紫外線吸収剤は、公知の化合物が使用できる。例えば、サリチル酸系化合物、ベンゾフェノン系化合物、ベンゾトリアゾール系化合物が挙げられる。紫外線吸収剤は、単独または２種類以上を併用できる。 Known compounds can be used as the ultraviolet absorber. Examples include salicylic acid compounds, benzophenone compounds, and benzotriazole compounds. The ultraviolet absorber can be used alone or in combination of two or more.
光安定剤は、公知の化合物が使用できる。例えば、ヒンダードアミン系化合物が挙げられる。紫外線吸収剤は、単独または２種類以上を併用できる。 Known compounds can be used as the light stabilizer. Examples include hindered amine compounds. The ultraviolet absorber can be used alone or in combination of two or more.
シランカップリング剤は、例えばビニルトリメトキシシラン、ビニルトリエトキシシラン、メタクリロキシプロピルトリメトキシシラン、３−メタクリロキシプロピルメチルジメトキシシラン、３−グリシドキシプロピルトリメトキシシラン、３−グリシドキシプロピルトリエトキシシラン、３−グリシドキシプロピルメチルジメトキシシラン、３−グリシドキシプロピルメチルジエトキシシラン、２−（３，４−エポキシシクロヘキシル）エチルトリメトキシシラン、３−アミノプロピルトリメトキシシラン、３−アミノプロピルトリエトキシシラン、３−アミノプロピルメチルジメトキシシラン、Ｎ−（２−アミノエチル）３−アミノプロピルトリメトキシシラン、Ｎ−（２−アミノエチル）３−アミノプロピルメチルジメトキシシラン、３−メルカプトプロピルトリメトキシシラン、３−メルカプトプロピルトリエトキシシラン、メルカプトブチルトリメトキシシラン、３−メルカプトプロピルメチルジメトキシシランが挙げられる。シランカップリング剤は、単独または２種類以上を併用できる。 Silane coupling agents include, for example, vinyltrimethoxysilane, vinyltriethoxysilane, methacryloxypropyltrimethoxysilane, 3-methacryloxypropylmethyldimethoxysilane, 3-glycidoxypropyltrimethoxysilane, 3-glycidoxypropyltri Ethoxysilane, 3-glycidoxypropylmethyldimethoxysilane, 3-glycidoxypropylmethyldiethoxysilane, 2- (3,4-epoxycyclohexyl) ethyltrimethoxysilane, 3-aminopropyltrimethoxysilane, 3-amino Propyltriethoxysilane, 3-aminopropylmethyldimethoxysilane, N- (2-aminoethyl) 3-aminopropyltrimethoxysilane, N- (2-aminoethyl) 3-aminopropylmethyldimethoxysilane 3-mercaptopropyl trimethoxysilane, 3-mercaptopropyl triethoxy silane, mercaptopropyl butyl trimethoxy silane include 3-mercaptopropyl methyl dimethoxy silane. A silane coupling agent can be used alone or in combination of two or more.
抗菌剤は、例えばブテナフィン及びその塩等のベンジルアミン系抗菌剤；ビフォナゾール、ネチコナゾール、ケトコナゾール、ラノコナゾール、クロトリマゾール、ミコナゾール、オキシコナゾール、チオコナゾール、クロコナゾール、オモコナゾール、スルコナゾール及びこれらの塩等のイミダゾール系抗菌剤；テルビナフィン及びその塩などのアリルアミン系抗菌剤；アモロルフィン及びその塩等のモルホリン系抗菌剤；リラナフタート、トルナフテート及びトルシクラート等のチオカルバミン酸系抗菌剤；ナイスタチン、トリコマイシン、バリオチン、シッカニン、ピロールニトリン等の抗生物質等の抗菌剤；熊笹エキス、茶カテキンが挙げられる。抗菌剤は、単独または２種類以上を併用できる。 Antibacterial agents include benzylamine antibacterial agents such as butenafine and salts thereof; imidazoles such as bifonazole, neticonazole, ketoconazole, ranoconazole, clotrimazole, miconazole, oxyconazole, thioconazole, croconazole, omoconazole, sulconazole and salts thereof Allylamine antibacterial agents such as terbinafine and its salts; morpholine antibacterial agents such as amorolfine and its salts; thiocarbamic acid antibacterial agents such as lirannaphthate, tolnaftate and tolcyclate; nystatin, tricomycin, variotin, siccanin, pyrrolnitrile Antibacterial agents such as antibiotics such as urine; Kumagusu extract and tea catechin. Antibacterial agents can be used alone or in combination of two or more.
消臭剤は、消臭効果を有する公知の化合物が好ましい。例えば、ラウリルメタクリレート、ゲラニルクロリネート、シトロネリルセネシオネート、テルペンアルデヒド類、ピルビン酸エステル、２−エチルヘキサン酸亜鉛、リシノール酸亜鉛が挙げられる。消臭剤は、単独または２種類以上を併用できる。 The deodorant is preferably a known compound having a deodorizing effect. For example, lauryl methacrylate, geranyl chloride, citronellyl senecionate, terpene aldehydes, pyruvate, zinc 2-ethylhexanoate, zinc ricinoleate can be mentioned. The deodorizer can be used alone or in combination of two or more.
香料は、例えばピネン、リモネン等の炭化水素系香料、リナロール、ゲラニオール、シトロネロール、メントール、ボルネオール、ベンジルアルコール、アニスアルコール、β−フェネチルアルコール等のアルコール系香料、アネトール、オイゲノール等のフェノール系香料、ｎ−ブチルアルデヒド、イソブチルアルデヒド、ヘキシルアルデヒド、シトラール、シトロネラール、ベンズアルデヒド、シンナミックアルデヒド等のアルデヒド系香料、カルボン、メントン、樟脳、アセトフェノン、イオノン等のケトン系香料、γ―ブチルラクトン、クマリン、シネオール等のラクトン系香料、オクチルアセテート、ベンジルアセテート、シンナミルアセテート、プロピオン酸ブチル、安息香酸メチル等のエステル系香料が挙げられる。香料は、単独または２種類以上を併用できる。 Fragrances include, for example, hydrocarbon-based fragrances such as pinene and limonene, linalool, geraniol, citronellol, menthol, borneol, benzyl alcohol, anis alcohol, β-phenethyl alcohol, and other phenol-based fragrances such as anethole and eugenol, n -Aldehyde fragrances such as butyraldehyde, isobutyraldehyde, hexyl aldehyde, citral, citronellal, benzaldehyde, cinnamic aldehyde, ketone fragrances such as carvone, menthone, camphor, acetophenone, ionone, γ-butyl lactone, coumarin, cineol, etc. Examples include lactone-based fragrances, ester-based fragrances such as octyl acetate, benzyl acetate, cinnamyl acetate, butyl propionate, and methyl benzoate. A fragrance | flavor can be used individually or in combination of 2 or more types.
保湿剤は、例えば１，３−ブチレングリコール、プロピレングリコール、ジプロピレングリコール、グリセリン、マルチトール、トレハロースなどの多価アルコール、ピロリドンカルボン酸、乳酸、尿素、アミノ酸などの天然保湿因子（Natural Moisturizing Factor／ＮＭＦ成分）、ヘパリン、ヒアルロン酸、コンドロイチン硫酸、キチン、キトサン、アルギン酸ナトリウム、アロエ、ペクチンなどの多糖類、コラーゲン、エラスチン、ケラチン、ゼラチン、カゼイン、シルク、小麦プロテイン、ワセリン、大豆プロテイン、ＤＮＡなどのペブチド及びその加水分解物、塩化ナトリウム、海水などのミネラル、セラミド、コレステロールエステルが挙げられる。保湿剤は、単独または２種類以上を併用できる。 Examples of the humectant include natural moisturizing factors such as polyhydric alcohols such as 1,3-butylene glycol, propylene glycol, dipropylene glycol, glycerin, maltitol and trehalose, pyrrolidone carboxylic acid, lactic acid, urea and amino acids. NMF component), heparin, hyaluronic acid, chondroitin sulfate, chitin, chitosan, sodium alginate, aloe, pectin and other polysaccharides, collagen, elastin, keratin, gelatin, casein, silk, wheat protein, petrolatum, soy protein, DNA, etc. Peptides and hydrolysates thereof, sodium chloride, minerals such as seawater, ceramides, cholesterol esters. The humectant can be used alone or in combination of two or more.
吸水剤は、例えばデンプン、架橋カルボキシルメチル化セルロース、アクリル酸またはアクリル酸アルカリ金属塩の重合体ならびにその共重合体、架橋ポリアクリル酸およびその塩ならびにポリアクリル酸塩グラフト重合体が挙げられる。吸水剤は、単独または２種類以上を併用できる。 Examples of the water absorbing agent include starch, crosslinked carboxylmethylated cellulose, a polymer of acrylic acid or an alkali metal acrylate and a copolymer thereof, a crosslinked polyacrylic acid and a salt thereof, and a polyacrylate graft polymer. The water absorbing agent can be used alone or in combination of two or more.
電解質塩は、例えばハロゲン化ナトリウム、ハロゲン化カリウム、ハロゲン化マグネシウム、ハロゲン化カルシウム等のハロゲン化アルカリ金属；ハロゲン化アルカリ土類金属または他の金属ハロゲン化物；各種金属の次亜塩素酸塩、亜塩素酸塩、塩素酸塩、過塩素酸塩、硫酸塩、硝酸塩、燐酸塩、アンモニウム塩；各種錯塩等の無機塩；酢酸、安息香酸、乳酸、酒石酸等の一価カルボン酸塩；フマル酸、コハク酸、アジビン酸、クエン酸等の多価カルボン酸塩；スルホン酸、アミノ酸金属塩；有機アンモニウム塩；ポリ（メタ）アクリル酸、ポリビニルスルホン酸、ポリターシャルブチルアクリルアミドスルホン酸、ポリアリルアミン、ポリエチレンイミン等の高分子電解質の塩が挙げられる。電解質塩は、単独または２種類以上を併用できる。 The electrolyte salt includes, for example, alkali metal halides such as sodium halide, potassium halide, magnesium halide, and calcium halide; alkaline earth metal halides or other metal halides; hypochlorites of various metals, Chlorates, chlorates, perchlorates, sulfates, nitrates, phosphates, ammonium salts; inorganic salts such as various complex salts; monovalent carboxylates such as acetic acid, benzoic acid, lactic acid, tartaric acid; fumaric acid, Polycarboxylic acid salts such as succinic acid, adipic acid and citric acid; sulfonic acid, amino acid metal salt; organic ammonium salt; poly (meth) acrylic acid, polyvinyl sulfonic acid, polytertiary butylacrylamide sulfonic acid, polyallylamine, polyethylene Examples thereof include a salt of a polymer electrolyte such as imine. The electrolyte salt can be used alone or in combination of two or more.
添加剤の配合量は、ホットメルト粘着剤１００重量％のうち、合計０．０１〜１０重量％程度である。 The compounding amount of the additive is about 0.01 to 10% by weight in total in 100% by weight of the hot melt pressure-sensitive adhesive.
＜ホットメルト粘着剤層（Ａ）＞
ホットメルト粘着剤層（Ａ）は、水分を透過させるため表面の空隙率が５％〜５０％であることが好ましい。空隙率が５％以上になると皮膚の蒸れやかゆみを抑制できる。また、空隙率が５０％以下になると粘着シートが意図せずに皮膚から剥がれることが減少する。なお、表面の空隙率とは粘着剤層１平方ミリメートルあたりに存在する孔の面積比率である。なお、ホットメルト粘着剤層（Ａ）がパターン塗工されている場合、粘着剤層の非形成部は、表面の空隙率を算出する場所として使用しない。
<Hot-melt adhesive layer (A)>
The hot melt pressure-sensitive adhesive layer (A) preferably has a surface porosity of 5% to 50% in order to allow moisture to permeate. When the porosity is 5% or more, it is possible to suppress stuffiness and itching of the skin. Moreover, when the porosity is 50% or less, the adhesive sheet is less intentionally peeled off from the skin. The surface porosity is an area ratio of holes existing per square millimeter of the pressure-sensitive adhesive layer. In addition, when the hot-melt pressure-sensitive adhesive layer (A) is pattern-coated, the non-formed portion of the pressure-sensitive adhesive layer is not used as a place for calculating the surface porosity.
また、ホットメルト粘着剤層（Ａ）は、１平方ミリメートル当たりに円相当径が１０〜４００μｍの孔を２個以上有する。円相当径が１０μｍ以上になると孔の形状を経時で保持しやすい。また、円相当径が４００μｍ以下になると粘着力と透湿性のバランスを取りやすい。孔を２個以上になると皮膚の蒸れやかゆみを抑制できる。孔は水分を透過できる貫通孔であればよく、その形状は限定されない。なお、円相当径は、３０μｍ〜３００μｍがより好ましく、３０μｍ〜２００μｍがさらに好ましい。
孔の個数は、１００ｍｍ四方のサンプルの任意の５か所について、１平方ミリメートルあたりの孔の個数を数え、任意の５か所の平均値を孔の個数とした。孔の形状は、例えば、円、楕円等の形状；勾玉、アメーバ状等の不定形が挙げられる。なお、孔は、３個以上が好ましく、５個以上がより好ましい。孔の個数の上限は、円相当径の大小により変動するため正確に定めることが難しいため規定できない。そのため孔の個数の上限は、表面の空隙率が５０％を超えない個数であれば良い。
The hot melt pressure-sensitive adhesive layer (A) has two or more holes having an equivalent circle diameter of 10 to 400 μm per square millimeter. When the equivalent circle diameter is 10 μm or more, the shape of the hole is easily retained over time. Further, when the equivalent circle diameter is 400 μm or less, it is easy to balance the adhesive force and moisture permeability. When there are two or more holes, it is possible to suppress the stuffiness and itching of the skin. The hole should just be a through-hole which can permeate | transmit moisture, and the shape is not limited. The equivalent circle diameter is more preferably 30 μm to 300 μm, and even more preferably 30 μm to 200 μm.
As for the number of holes, the number of holes per square millimeter was counted at any five locations of a 100 mm square sample, and the average value at any five locations was defined as the number of holes. Examples of the shape of the hole include shapes such as a circle and an ellipse; In addition, 3 or more holes are preferable, and 5 or more holes are more preferable. The upper limit of the number of holes cannot be specified because it varies depending on the equivalent circle diameter and is difficult to determine accurately. For this reason, the upper limit of the number of holes may be any number as long as the porosity of the surface does not exceed 50%.
前記孔は、真円や楕円のように径を算出し易い形状が少なく不定形が多いため、円相当径（面積円相当径）で定義する。なお、円相当径は、空隙（孔）一つの面積をＳとする場合に相当する直径（円相当径）：Ｌ＝√（４×Ｓ／π）で規定する。表面の空隙率の測定は、レーザーマイクロスコープ ＶＫ−Ｘ１００（キーエンス社製）を用い、１００ｍｍ四方のサンプルの任意５か所について、１平方ミリメートルあたりの空隙部分の面積の和を算出し、任意５か所の平均値を空隙率とした。また、円相当径：Ｌは、空隙１個あたりの面積を求めた後、上述式より算出した。 The hole is defined by a circle-equivalent diameter (area-equivalent circle diameter) because there are few irregular shapes such as a perfect circle and an ellipse and the shape is easy to calculate. The equivalent circle diameter is defined by a diameter (circle equivalent diameter) corresponding to a case where the area of one void (hole) is S: L = √ (4 × S / π). The surface porosity is measured by using a laser microscope VK-X100 (manufactured by Keyence Corporation), and calculating the sum of the area of the void portion per square millimeter for any five locations of a 100 mm square sample. The average value of the places was defined as the porosity. The equivalent circle diameter L was calculated from the above formula after obtaining the area per void.
ホットメルト粘着剤層（Ａ）の形状は、全面べた塗工で粘着剤層が形成されていても、パターン状に形成されていても、ドッド状に形成されていても、全くランダムな形状に形成されていても構わない。粘着剤層の形状に関わらず、所定の空隙率および孔の数を満たせばよい。 The shape of the hot melt pressure-sensitive adhesive layer (A) is completely random regardless of whether the pressure-sensitive adhesive layer is formed by solid coating, formed in a pattern, or formed in a dod shape. It may be formed. What is necessary is just to satisfy | fill predetermined porosity and the number of holes irrespective of the shape of an adhesive layer.
パターン状とは、格子状、ブロック状、ストライプ状、など一定絵柄の繰り返し模様をいい、粘着剤層部分と非粘着剤層が繰り返される。
パターン状にホットメルト粘着剤層を塗工する方法としては、公知の方法を使用できる。粘着剤層と非粘着剤層の面積比は、粘着剤層：非粘着剤層＝１０：１〜１０：１０の範囲が好ましい。粘着剤層の比率が非粘着剤層と同等以上であると粘着力がより向上する。
The pattern shape means a repetitive pattern having a certain pattern such as a lattice shape, a block shape, or a stripe shape, and the adhesive layer portion and the non-adhesive layer are repeated.
As a method for applying the hot melt pressure-sensitive adhesive layer in a pattern, a known method can be used. The area ratio between the pressure-sensitive adhesive layer and the non-pressure-sensitive adhesive layer is preferably in the range of pressure-sensitive adhesive layer: non-pressure-sensitive adhesive layer = 10: 1 to 10:10. When the ratio of the pressure-sensitive adhesive layer is equal to or higher than that of the non-pressure-sensitive adhesive layer, the adhesive force is further improved.
ホットメルト粘着剤層（Ａ）は、厚さ１０〜２００μｍであることが好ましく、より好ましくは３０μｍ〜１００μｍの範囲である。この範囲を満たすことで、粘着力がより向上する。 The hot melt pressure-sensitive adhesive layer (A) preferably has a thickness of 10 to 200 μm, more preferably 30 μm to 100 μm. By satisfy | filling this range, adhesive force improves more.
＜粘着シートの製造方法＞
本発明の粘着シートの製造方法は、ホットメルト粘着剤層（Ｘ）と、通気性フォーム体とを加熱圧着して、表面の空隙率が５〜５０％、かつ１平方ミリメートル当たり円相当径が１０〜４００μｍの孔を２個以上有するホットメルト粘着剤層（Ａ）を形成できれば良く、その製造方法は限定されない。
<Method for producing adhesive sheet>
In the method for producing the pressure-sensitive adhesive sheet of the present invention, the hot-melt pressure-sensitive adhesive layer (X) and the breathable foam body are heat-pressed, and the surface porosity is 5 to 50% and the equivalent circle diameter per square millimeter is The manufacturing method is not limited as long as the hot melt pressure-sensitive adhesive layer (A) having two or more 10 to 400 μm holes can be formed.
粘着シートの製造方法の好ましい実施態様の一つは、下記の通りである。
ホットメルト粘着剤層（Ｘ）と、通気性フォーム体とを加熱圧着して、ホットメルト粘着剤層（Ａ）を形成することが好ましい。前記加熱圧着によりホットメルト粘着剤層（Ｘ）と通気性フォーム体が圧縮されながらホットメルト粘着剤層（Ｘ）の一部が多数の孔を有する通気性フォーム体に沈み込みつつ（含浸しつつ）、粘着剤層に通気性フォーム体の孔に基づく孔が形成されることでホットメルト粘着剤層（Ａ）が得られる。
加熱圧着に用いる装置は、例えば加熱ロールラミネーターが挙げられる。
One of the preferable embodiments of the method for producing the pressure-sensitive adhesive sheet is as follows.
The hot melt pressure-sensitive adhesive layer (X) and the breathable foam body are preferably heat-pressed to form the hot-melt pressure-sensitive adhesive layer (A). While the hot-melt pressure-sensitive adhesive layer (X) and the breathable foam body are compressed by the thermocompression bonding, a part of the hot-melt pressure-sensitive adhesive layer (X) is submerged (impregnated) into the breathable foam body having a large number of holes. ), A hot melt pressure-sensitive adhesive layer (A) is obtained by forming holes based on the holes of the breathable foam body in the pressure-sensitive adhesive layer.
An apparatus used for thermocompression bonding includes, for example, a heated roll laminator.
ホットメルト粘着剤層（Ｘ）は、剥離性シート上に予め加熱溶融させたホットメルト粘着剤を塗工し、形成する。ホットメルト粘着剤層（Ｘ）の厚さは、５０μｍ〜３００μｍが好ましく、８０〜２００μｍがより好ましい。厚さが所定の範囲内にあることで通気性フォーム体との密着性および粘着力がより向上し、所望の空隙率および孔が得易い。
粘着剤の加熱溶融温度は、粘着剤の組成に応じて１００℃〜２００℃に設定され、塗工は、例えばコンマコーター、ダイコーターなど公知のホットメルト塗工機で一定膜厚塗工する。
The hot-melt pressure-sensitive adhesive layer (X) is formed by applying a hot-melt pressure-sensitive adhesive previously heated and melted on a peelable sheet. The thickness of the hot melt pressure-sensitive adhesive layer (X) is preferably 50 μm to 300 μm, and more preferably 80 to 200 μm. When the thickness is within the predetermined range, the adhesiveness and adhesive strength with the breathable foam body are further improved, and desired porosity and pores are easily obtained.
The heating and melting temperature of the pressure-sensitive adhesive is set to 100 ° C. to 200 ° C. according to the composition of the pressure-sensitive adhesive, and the coating is performed with a constant film thickness using a known hot melt coating machine such as a comma coater or a die coater.
剥離性シートは、表面に剥離剤を塗布し、公知の素材を使用したシートを使用できるところ表面が平滑なシートが好ましい。素材は、例えば、ポリエチレンテレフタレート（ＰＥＴ）等のプラスチック、ならびに紙のシートにポリエチレンテレフタレートを貼り合わせた、いわゆるポリラミシートが挙げられる。 The release sheet is preferably a sheet having a smooth surface where a release agent is applied to the surface and a sheet using a known material can be used. Examples of the material include plastics such as polyethylene terephthalate (PET), and so-called polylaminated sheets in which polyethylene terephthalate is bonded to a paper sheet.
加熱圧着は、例えばロール圧着、平版圧着が挙げられる。これらの中でも生産性の面でロール圧着がより好ましい。
加熱圧着の温度は、ホットメルト粘着剤に配合する原料の選択により適宜設定すれば良く限定されないところ、６０〜１２０℃程度が好ましく、７０〜１００℃程度がより好ましい。
Examples of the thermocompression bonding include roll pressure bonding and planographic pressure bonding. Among these, roll press bonding is more preferable in terms of productivity.
The temperature for thermocompression bonding is not particularly limited as long as it is appropriately set depending on the selection of raw materials to be blended in the hot melt pressure-sensitive adhesive, but is preferably about 60 to 120 ° C, more preferably about 70 to 100 ° C.
加熱圧着の圧力は、通気性フォーム体の硬さや孔等の密度の程度、ならびにホットメルト粘着剤に配合する原料の選択により適宜設定すれば良く限定されないところ、平版圧着であれば、例えば１平方ｃｍ当たり０．２〜５ｋｇ程度が好ましい。また、ロール圧着であれば、例えば１ｃｍ当たりの線圧が０．１〜５ｋｇ程度が好ましい。 The pressure of thermocompression bonding is not limited as long as it is set appropriately depending on the hardness of the breathable foam body, the density of pores, etc., and the selection of the raw material to be blended in the hot melt pressure-sensitive adhesive. About 0.2-5 kg per cm is preferable. In the case of roll pressure bonding, for example, the linear pressure per 1 cm is preferably about 0.1 to 5 kg.
ホットメルト粘着剤層（Ａ）は、プレス前のホットメルト粘着剤層（Ｘ）の一部が通気性フォーム体に沈み込むことで、厚さ１０〜２００μｍの粘着剤層が形成されることが好ましく、より好ましくは３０μｍ〜１００μｍである。 In the hot melt pressure-sensitive adhesive layer (A), a part of the hot-melt pressure-sensitive adhesive layer (X) before pressing sinks into the breathable foam body, whereby a pressure-sensitive adhesive layer having a thickness of 10 to 200 μm is formed. Preferably, it is 30 μm to 100 μm.
また、所望の空隙率および孔を有するホットメルト粘着剤層（Ａ）を作成する他の実施態様は、例えば、通気性フォーム体および粘着剤層を備えた粘着シートの粘着剤層側から剣山（けんざん）のように複数の針を有する装置（ないし機材等）を通気性フォーム体側に向けて押し込むことでホットメルト粘着剤層（Ａ）を形成する方法や、ホットメルト粘着剤層（Ｘ）を、エアを混入し加熱溶融されたホットメルト粘着剤を従来公知の塗工方式で塗工したり、ホットメルト粘着剤をスプレー状に塗工して形成し、ホットメルト粘着剤層（Ｘ）と通気性フォーム体と加熱圧着し、所望の空隙率および孔を有するホットメルト粘着剤層（Ａ）を形成する方法、通気性基材に、エアを混入し加熱溶融されたホットメルト粘着剤を従来公知の塗工方式で直接塗工したり、ホットメルト粘着剤をスプレー状に直接塗工しホットメルト粘着剤層（Ａ）を形成する方法などが挙げられる。
なお、本発明の皮膚貼付用粘着シートは、ホットメルト粘着剤層（Ａ）が、表面の空隙率が５〜５０％であり、１平方ミリメートル当たりに円相当径が１０〜４００μｍの孔を２個以上有するという構成を満たせば良いため、その製造方法は、これまでに説明した方法に限定されないことはいうまでもない。
Another embodiment for producing a hot melt pressure-sensitive adhesive layer (A) having a desired porosity and pores is, for example, from the pressure-sensitive adhesive layer side of the pressure-sensitive adhesive sheet provided with a breathable foam body and a pressure-sensitive adhesive layer from Kenzan ( A method of forming a hot melt pressure-sensitive adhesive layer (A) by pushing a device (or equipment, etc.) having a plurality of needles toward the breathable foam body side, such as Kenzan, or a hot-melt pressure-sensitive adhesive layer (X) The hot-melt pressure-sensitive adhesive mixed with air and heated and melted is applied by a conventionally known coating method, or the hot-melt pressure-sensitive adhesive is applied in a spray form to form a hot-melt pressure-sensitive adhesive layer (X) A method of forming a hot-melt pressure-sensitive adhesive layer (A) having a desired porosity and pores by thermocompression bonding with a breathable foam body, and a conventional hot-melt pressure-sensitive adhesive that is heated and melted by mixing air into a breathable base material Known coating method Direct or coating, and a method of forming a hot-melt adhesive layer (A) directly applying a hot melt adhesive to the spray shape and the like.
In the pressure-sensitive adhesive sheet for skin application of the present invention, the hot melt pressure-sensitive adhesive layer (A) has a surface porosity of 5 to 50% and 2 holes with an equivalent circle diameter of 10 to 400 μm per square millimeter. Needless to say, the manufacturing method is not limited to the methods described so far, as long as the configuration of having more than one is satisfied.
ホットメルト粘着剤層（Ａ）の厚さは、ホットメルト粘着剤層（Ｘ）が通気性フォーム体に沈み込んだ部分を除き、通気性フォーム体から独立して観察できる粘着剤層部分のみの厚さである。ホットメルト粘着剤層（Ａ）の厚さは、粘着テープの断面を光学顕微鏡や電子顕微鏡を用いて測定できる。 The thickness of the hot-melt pressure-sensitive adhesive layer (A) is such that only the pressure-sensitive adhesive layer portion that can be observed independently from the breathable foam body, excluding the portion where the hot-melt pressure-sensitive adhesive layer (X) sinks into the breathable foam body. Is the thickness. The thickness of the hot melt pressure-sensitive adhesive layer (A) can be measured using an optical microscope or an electron microscope for the cross section of the pressure-sensitive adhesive tape.
＜粘着シートの用途＞
本発明の粘着シートの用途は、皮膚貼付用途に限らず、被着体から放出される液体を通過させる用途に使用できる。皮膚貼付用途でいうと、例えば、絆創膏、貼付剤、パップ剤、テーピング、医療機器固定用テープ、サージカルテープなどが挙げられる。なお、被着体とは、粘着シートを貼り付ける相手方である。
<Use of adhesive sheet>
The application of the pressure-sensitive adhesive sheet of the present invention is not limited to the application to the skin, and can be used for the purpose of allowing the liquid released from the adherend to pass through. In terms of skin application, examples thereof include adhesive bandages, patches, poultices, taping, medical device fixing tapes, and surgical tapes. In addition, a to-be-adhered body is the other party which affixes an adhesive sheet.
以下、本発明を実施例により具体的かつ詳細に説明するが、これらの実施例は本発明の
一態様に過ぎず、本発明はこれらの例によって限定されるものではない。なお、以下「部」は「重量部」を意味し、「％」は「重量％」を意味する。
EXAMPLES Hereinafter, the present invention will be described specifically and in detail with reference to examples. However, these examples are only one aspect of the present invention, and the present invention is not limited to these examples. Hereinafter, “part” means “part by weight”, and “%” means “% by weight”.
実施例で使用する原料は下記の通りである。
＜スチレン系ブロック共重合体＞
ＳＥＢＳ１：ＳＥＢＳ、スチレンの比率３０重量％、トリブロック含有１００％
ＳＥＢＳ２：ＳＥＢＳ、スチレンの比率３０重量％、トリブロック含有３０％、ジブロック含有７０％
ＳＥＢＳ３：ＳＥＢＳ、スチレンの比率６０重量％、トリブロック含有１００％
ＳＥＰＳ１：ＳＥＰＳ、スチレンの比率２０重量％、トリブロック含有１００％
ＳＥＰＳ２：ＳＥＰＳ、スチレンの比率２５重量％、トリブロック含有１００％
ＳＩＳ１：ＳＩＳ、スチレンの比率１９重量％、トリブロック含有１００％
ＳＩＳ２：ＳＩＳ、スチレンの比率２４重量％、トリブロック含有７０％、ジブロック含有３０％
The raw materials used in the examples are as follows.
<Styrenic block copolymer>
SEBS1: SEBS, styrene ratio 30% by weight, triblock content 100%
SEBS2: SEBS, styrene ratio 30% by weight, triblock content 30%, diblock content 70%
SEBS3: SEBS, styrene ratio 60% by weight, triblock content 100%
SEPS1: SEPS, styrene ratio 20% by weight, triblock content 100%
SEPS2: SEPS, styrene ratio 25% by weight, triblock content 100%
SIS1: SIS, styrene ratio 19% by weight, triblock content 100%
SIS2: SIS, styrene ratio 24% by weight, triblock content 70%, diblock content 30%
＜軟化剤＞
軟化剤１：パラフィン系鉱物油
軟化剤２：流動パラフィン
軟化剤３：ナフテン系鉱物油
<Softener>
Softener 1: Paraffinic mineral oil softener 2: Liquid paraffin softener 3: Naphthenic mineral oil
＜粘着付与剤＞
粘着付与剤１：テルペン系樹脂 軟化点１００℃
粘着付与剤２：ロジンエステル系樹脂 軟化点１１０℃
粘着付与剤３：水素添加された石油系樹脂 軟化点９０℃
<Tackifier>
Tackifier 1: Terpene resin Softening point 100 ° C
Tackifier 2: Rosin ester resin Softening point 110 ° C
Tackifier 3: Hydrogenated petroleum resin Softening point 90 ° C
＜粘着剤の作成＞
スチレン系ブロック共重合体としてＳＥＢＳ１を１０部、ＳＥＢＳ２を３部、ＳＥＰＳ１を２０部、軟化剤１を４０部、粘着付与剤１を２７部を攪拌機を備えたニーダーに投入し、１６０℃加熱下３時間撹拌を行い、粘着剤１を得た。
<Creation of adhesive>
As a styrenic block copolymer, 10 parts of SEBS1, 3 parts of SEBS2, 20 parts of SEPS1, 40 parts of
粘着剤１の原料および配合量を表１に記載された通りに変更した以外は、粘着剤１と同様に行うことでそれぞれ粘着剤２〜８を得た。 Except having changed the raw material and compounding quantity of adhesive 1 as described in Table 1, it carried out similarly to adhesive 1, and obtained adhesives 2-8, respectively.
＜実施例１＞
得られた粘着剤１をホットメルト塗工機を使用してＰＥＴ製剥離性シート上に厚さ１５０μｍにべた塗り塗工して、ホットメルト粘着剤層（Ｘ）を得た。得られたホットメルト粘着剤層（Ｘ）と、厚さ１ｍｍの軟質ポリウレタンフォーム（水蒸気透過率４０００ｇ／ｍ２・２４時間）とをロール式の加熱ラミネーターを用いて温度８０℃・圧力２ＭＰａ・速度１Ｍ／分の加熱圧着条件で貼り合せ、ホットメルト粘着剤層（Ａ）の厚さが１００μｍの皮膚貼付用粘着テープを得た。
得られた皮膚貼付用粘着テープのホットメルト粘着剤層（Ａ）の表面をレーザーマイクロスコープ（ＶＫ−Ｘ１００ キーエンス社製）で観察したところ、１平方ミリメートル当たり平均４個の孔を有し、その表面空隙率は２０％であった。
<Example 1>
The obtained pressure-
When the surface of the hot melt pressure-sensitive adhesive layer (A) of the obtained adhesive tape for skin application was observed with a laser microscope (VK-X100, manufactured by Keyence Corporation), it had an average of 4 holes per square millimeter. The surface porosity was 20%.
＜実施例２〜８ならびに比較例１〜２＞
実施例１の粘着剤１を表２に記載された粘着剤、ホットメルト粘着剤層厚み、加熱圧着条件に変更した以外は、実施例１と同様に行うことでそれぞれ実施例２〜８ならびに比較例１〜２の皮膚貼付用粘着テープを得た。次いで実施例１と同様にホットメルト粘着剤層（Ａ）の表面を観察した。孔の平均個数および空隙率は表２に記載した。
<Examples 2-8 and Comparative Examples 1-2>
Except having changed the
＜実施例９＞
図１に示す粘着剤層の幅１１ ２ｍｍ、および着剤層の塗工間隔１２ ２ｍｍのストライプ状に粘着剤層を形成可能な塗工ヘッドを有するホットメルトダイコーターにて、ＰＥＴ製剥離性シート上に、粘着剤１を厚さ１００μｍ塗工して、ホットメルト粘着剤層（Ｘ）を作製した。得られたホットメルト粘着剤層（Ｘ）と、軟質ポリウレタンフォームを加熱ラミネーターを用いて表２に記載された条件で加熱圧着することで、厚さ５０μｍのホットメルト粘着剤層（Ａ）を有する皮膚貼付用粘着テープを得た。
得られた皮膚貼付用粘着テープのホットメルト粘着剤層（Ａ）は、レーザーマイクロスコープで観察したところ、１平方ミリメートル当たり平均３個の孔を有し、その表面空隙率は１０％であった。
<Example 9>
In a hot melt die coater having a coating head capable of forming a pressure-sensitive adhesive layer in a stripe shape having a width of 112 mm of the pressure-sensitive adhesive layer and a coating interval of 122 mm of the adhesive layer shown in FIG. On top, the adhesive 1 was applied to a thickness of 100 μm to prepare a hot-melt adhesive layer (X). The obtained hot melt pressure-sensitive adhesive layer (X) and the hot polyurethane pressure-sensitive adhesive layer (A) having a thickness of 50 μm are obtained by thermocompression bonding the flexible polyurethane foam under the conditions described in Table 2 using a heating laminator. An adhesive tape for skin application was obtained.
When the hot melt pressure-sensitive adhesive layer (A) of the obtained adhesive tape for skin application was observed with a laser microscope, it had an average of 3 holes per square millimeter and its surface porosity was 10%. .
＜実施例１０＞
図２に示す粘着剤層の幅２１（メッシュ幅）２ｍｍ、および粘着剤層の塗工間隔２２（幅）２ｍｍ・粘着剤層の塗工間隔２３（縦）２ｍｍのメッシュ状に粘着剤層を形成可能な塗工ヘッドを有するホットメルトダイコーターにて、ＰＥＴ製剥離性シート上に粘着剤２を厚さ１５０μｍ塗工して、ホットメルト粘着剤層（Ｘ）を作製した。得られたホットメルト粘着剤層（Ｘ）と、軟質ポリウレタンフォーム（厚み１ｍｍ）を加熱ラミネーターを用いて表２に記載しした条件で加熱圧着することで、厚さ１００μｍのホットメルト粘着剤層（Ａ）を有する皮膚貼付用粘着テープを得た。
得られた皮膚貼付用粘着テープのホットメルト粘着剤層（Ａ）は、レーザーマイクロスコープで観察したところ、１平方ミリメートル当たり平均６個の孔を有し、その表面空隙率は３０％であった。
<Example 10>
The pressure-sensitive adhesive layer is formed into a mesh having a width 21 (mesh width) of the pressure-sensitive adhesive layer shown in FIG. 2 and a coating interval 22 (width) of the pressure-sensitive adhesive layer of 2 mm and a coating interval 23 (length) of the pressure-sensitive adhesive layer of 2 mm. A hot melt pressure-sensitive adhesive layer (X) was prepared by coating the adhesive 2 with a thickness of 150 μm on a PET peelable sheet using a hot melt die coater having a coatable coating head. The obtained hot-melt pressure-sensitive adhesive layer (X) and a flexible polyurethane foam (
The hot melt pressure-sensitive adhesive layer (A) of the obtained adhesive tape for skin application had an average of 6 holes per square millimeter when observed with a laser microscope, and the surface porosity was 30%. .
＜比較例３＞
アクリル系粘着剤（ＢＰＳ４８４９−４０：トーヨーケム社製、不揮発分４０％）を１００部、硬化剤（ＢＨＳ８５１５：イソシアネート硬化剤 トーヨーケム社製 不揮発分３７．５％）を２．５部混合し、ハンドアプリケーターを使用してＰＥＴ製剥離性シート上にべた塗り塗工し、乾燥を行うことで厚さ５０μｍの粘着剤層（Ｘ）を得た。得られた粘着剤層（Ｘ）と軟質ポリウレタンフォーム（厚み１ｍｍ）とをラミネーターを用いて表２に記載する条件で加熱圧着することで、厚さ２０μｍの粘着剤層（Ａ）を有する皮膚貼付用粘着テープを得た。
得られた皮膚貼付用粘着テープの粘着剤層（Ａ）は、１平方ミリメートル当たり円相当径１０〜４００μｍの範囲内の孔を０個有し、表面空隙率は０％であった。
<Comparative Example 3>
Mix 100 parts of acrylic pressure-sensitive adhesive (BPS4849-40: manufactured by Toyochem, nonvolatile content 40%) and 2.5 parts of curing agent (BHS8515: isocyanate curing agent, nonvolatile content 37.5% manufactured by Toyochem), and then apply a hand applicator. The adhesive layer (X) having a thickness of 50 μm was obtained by applying a solid coating on a PET peelable sheet using a lye and drying. A skin patch having a pressure-sensitive adhesive layer (A) having a thickness of 20 μm by thermocompression bonding of the obtained pressure-sensitive adhesive layer (X) and flexible polyurethane foam (
The pressure-sensitive adhesive layer (A) of the obtained pressure-sensitive adhesive tape for skin application had 0 holes in a circle equivalent diameter of 10 to 400 μm per square millimeter, and the surface porosity was 0%.
＜比較例４＞
比較例３の粘着剤および硬化剤をウレタン系粘着剤（ＳＰ７００：トーヨーケム社製、不揮発分４５％）に、硬化剤（ＢＸＸ５６２７：イソシアネート硬化剤 トーヨーケム社製 不揮発分５０％）を１部に変更した以外は比較例３と同様の方法で行うことで、表２に示す皮膚貼付用粘着テープを作製した。
<Comparative Example 4>
The pressure-sensitive adhesive and curing agent in Comparative Example 3 were changed to a urethane-based pressure-sensitive adhesive (SP700: manufactured by Toyochem Corp., nonvolatile content: 45%), and the curing agent (BXX5627: isocyanate curing agent, manufactured by Toyochem Corp., nonvolatile content: 50%) was changed to 1 part. Except for the above, the same method as in Comparative Example 3 was followed to produce the adhesive tape for skin application shown in Table 2.
＜比較例５＞
得られた粘着剤１を、ホットメルト塗工機を使用してＰＥＴ製剥離性シート上に厚さ５０μｍにべた塗り塗工して、ホットメルト粘着剤層（Ｘ）を得た。表２に記載した条件で得られたホットメルト粘着剤層（Ｘ）と、厚さ１ｍｍの軟質ポリウレタンフォーム（水蒸気透過率４０００ｇ／ｍ２・２４時間）とを加熱ラミネーターを用いて温度８０℃・圧力２ＭＰａ・速度１Ｍ／分の加熱圧着条件で貼り合せ、ホットメルト粘着剤層（Ａ）の厚さが３０μｍの皮膚貼付用粘着テープを得た。
得られた皮膚貼付用粘着テープのホットメルト粘着剤層（Ａ）の表面をレーザーマイクロスコープ（ＶＫ−Ｘ１００ キーエンス社製）で観察したところ、１平方ミリメートル当たり平均４個の孔を有し、その表面空隙率は７０％であった。
<Comparative Example 5>
The obtained pressure-
When the surface of the hot melt pressure-sensitive adhesive layer (A) of the obtained adhesive tape for skin application was observed with a laser microscope (VK-X100, manufactured by Keyence Corporation), it had an average of 4 holes per square millimeter. The surface porosity was 70%.
＜比較例６＞
実施例９と同様にストライプ状の厚さ１００μｍのホットメルト粘着剤層（Ｘ）を作製した。表２に記載した条件で得られたホットメルト粘着剤層（Ｘ）と、軟質ポリウレタンフォームを加熱ラミネーターを用いて加熱圧着することで、厚さ５０μｍのホットメルト粘着剤層（Ａ）を有する皮膚貼付用粘着テープを得た。
得られた皮膚貼付用粘着テープのホットメルト粘着剤層（Ａ）は、レーザーマイクロスコープで観察したところ、１平方ミリメートル当たり平均０個の孔を有し、その表面空隙率は０％であった。
<Comparative Example 6>
In the same manner as in Example 9, a stripe-shaped hot melt pressure-sensitive adhesive layer (X) having a thickness of 100 μm was produced. Skin having a hot-melt pressure-sensitive adhesive layer (A) having a thickness of 50 μm by hot-pressing a hot-melt pressure-sensitive adhesive layer (X) obtained under the conditions described in Table 2 and a flexible polyurethane foam using a heating laminator A sticky adhesive tape was obtained.
The hot melt pressure-sensitive adhesive layer (A) of the obtained adhesive tape for skin application had an average of 0 holes per square millimeter when observed with a laser microscope, and the surface porosity was 0%. .
得られた皮膚貼付用粘着テープについて下記項目を評価した。 The following items were evaluated for the obtained adhesive tape for skin application.
＜自着面粘着力＞
自着面粘着力は、皮膚に貼付する前に粘着剤層同士を誤って接触させた場合、剥離後の粘着シートを使用できるか否かの面で評価する。
得られた皮膚貼付用粘着シートを縦２５ｍｍ横１５０ｍｍの大きさに２枚準備して試料として。次いで２枚の試料から剥離性フィルムを剥がし、試料の粘着剤層同士を重ね、通気性フォーム体上からローラー（重さ５００ｇ）を１往復させて圧着し貼り合せた。貼り合せ後、一方の通気性フォーム体の面をステンレス（ＳＵＳ）板上に両面粘着テープで固定し、他方の方の通気性フォーム体の面を剥離角度１８０度、剥離速度５０ｍｍ／分の速度で剥がし、粘着剤層同士の粘着力の測定し自着面粘着力とした。
<Self-adhesive surface adhesive strength>
The self-adhesive surface adhesive strength is evaluated in terms of whether or not the adhesive sheet after peeling can be used when the adhesive layers are mistakenly contacted before being attached to the skin.
Two sheets of the obtained adhesive sheet for skin application were prepared in a size of 25 mm in length and 150 mm in width and used as samples. Subsequently, the peelable film was peeled off from the two samples, the adhesive layers of the samples were overlapped, and the roller (weight 500 g) was reciprocated once from above the breathable foam body, followed by bonding. After bonding, the surface of one air permeable foam body is fixed on a stainless steel (SUS) plate with a double-sided adhesive tape, and the surface of the other air permeable foam body has a peeling angle of 180 degrees and a peeling speed of 50 mm / min. The adhesive strength between the pressure-sensitive adhesive layers was measured and used as the self-adhesive surface adhesive strength.
＜粘着力＞
得られた皮膚貼付用粘着シートを縦２５ｍｍ横１００ｍｍの大きさに２準備して試料としＪＩＳ Ｚ０２３７に準拠して粘着力を測定した。試料から剥離性シートを剥がし、露出した粘着剤層をＳＵＳ板に貼付し、通気性フォーム体上にロール（重さ２ｋｇ）を１往復させて圧着し、２０分経過後に粘着力を測定した。剥離条件は、剥離角度１８０度、剥離速度５０ｍｍ／分で行った。なお、皮膚の状態は個人差があり、数値がばらつくためＳＵＳ板を使用している。
<Adhesive strength>
Two prepared adhesive sheets for skin application having a size of 25 mm in length and 100 mm in width were used as samples, and the adhesive force was measured according to JIS Z0237. The peelable sheet was peeled off from the sample, the exposed pressure-sensitive adhesive layer was affixed to a SUS board, and a roll (weight 2 kg) was reciprocated once on the breathable foam body, and the adhesive strength was measured after 20 minutes. The peeling conditions were a peeling angle of 180 degrees and a peeling speed of 50 mm / min. The skin condition varies from individual to individual, and SUS plates are used because the values vary.
＜再貼付性＞
再貼付性は、皮膚貼付用粘着シートの貼付位置を誤った場合の貼り直しが可能か否か面で評価する。
上記粘着力試験を行った後の試料をローラー（重さ５００ｇ）を１往復させて圧着しＳＵＳ板に貼付し２０分経過後の粘着力を測定した。剥離条件は、剥離角度１８０度、剥離速度５０ｍｍ／分の速度で行った。再貼付性の評価基準は以下の通りである。
〇：２回目の粘着力と１回目の粘着力の差が２０％未満、良好
×：２回目の粘着力と１回目の粘着力の差が２０％以上、実用不可
<Re-stickability>
The re-stickability is evaluated in terms of whether or not the sticking position of the adhesive sheet for skin sticking is incorrect.
The sample after performing the above-mentioned adhesive strength test was reciprocated once by a roller (weight 500 g), adhered to an SUS plate, and the adhesive strength after 20 minutes was measured. The peeling conditions were a peeling angle of 180 degrees and a peeling speed of 50 mm / min. The evaluation criteria for re-stickability are as follows.
◯: The difference between the second adhesive strength and the first adhesive strength is less than 20%, good ×: The difference between the second adhesive strength and the first adhesive strength is 20% or more, impractical
＜皮膚貼付性＞
得られた粘着シートを、縦１０ｍｍ横５０ｍｍの大きさに準備して試料とした。次いで試料から剥離性シートを剥がし露出した粘着剤層を上腕の内側に貼付した。貼付２４時間後に試料を剥がし、剥離後に皮膚状態を目視で観察し以下の基準で評価した。なお、対象とした被験者数は２０名で、貼付箇所の蒸れ及びかゆみの発生有無を○△×で評価した。
１．蒸れ（水分による皮膚の白化）
○：蒸れが発生した人数が３人以下、良好
△：蒸れが発生した人数が４人〜８人、実用可
×：蒸れが発生した人数が９人以上、実用不可
××：貼付２４時間経過前に粘着シートが剥がれた。実用不可
２．かゆみ
○：かゆみが発生した人数が３人以下、良好
△：かゆみが発生した人数が４人〜８人、実用可
×：かゆみが発生した人数が９人以上、実用不可
××：貼付２４時間経過前に粘着シートが剥がれた。実用不可
<Skin adhesiveness>
The obtained adhesive sheet was prepared in a size of 10 mm in length and 50 mm in width and used as a sample. Next, the peelable sheet was peeled off from the sample, and the exposed pressure-sensitive adhesive layer was attached to the inner side of the upper arm. The sample was peeled off 24 hours after application, and the skin condition was visually observed after peeling and evaluated according to the following criteria. In addition, the subject number of subjects was 20 people, and the presence or absence of the occurrence of stuffiness and itching at the pasting site was evaluated by ○ △ ×.
1. Steaming (whitening of skin due to moisture)
○: Number of people with sultry is 3 or less, good △: Number of people with sultry is 4-8 people, practical use ×: Number of people with steaming is 9 or more, impractical use ××: Pasting 24 hours The adhesive sheet was peeled off before. 1. Not practical Itching ○: Number of people with itching is 3 or less, good △: Number of people with itching is 4-8, practical use ×: Number of people with itching is 9 or more, impractical use ××: 24 hours pasting The adhesive sheet peeled off before progress. Impractical
表２の結果から実施例１〜１０は、皮膚貼付で皮膚に蒸れやかゆみの発生が少ない効果に加え、適度な自着面粘着力を有することで粘着シートのロスが少なく、再貼付可能という予想外の効果が得られた。 From the results shown in Table 2, Examples 1 to 10 have the effect of less stuffiness and itching on the skin when applied to the skin, and have moderate self-adhesive surface adhesion, resulting in less loss of the adhesive sheet and being able to be reapplied. An unexpected effect was obtained.
１１ 粘着剤層の塗工幅
１２ 粘着剤層の塗工間隔
２１ 粘着剤層の幅
２２ 粘着剤層の塗工間隔
２３ 粘着剤層の塗工間隔
11 Adhesive
Claims (7)
前記ホットメルト粘着剤層（Ａ）は、表面の空隙率が５〜５０％であり、１平方ミリメートル当たりに円相当径が１０〜４００μｍの孔を２個以上有する、皮膚貼付用粘着シート。 A breathable foam body and a hot melt pressure-sensitive adhesive layer (A),
The hot-melt pressure-sensitive adhesive layer (A) is a pressure-sensitive adhesive sheet for skin application, having a surface porosity of 5 to 50% and two or more holes having a circle equivalent diameter of 10 to 400 μm per square millimeter.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2016216989A JP6809145B2 (en) | 2016-11-07 | 2016-11-07 | Adhesive sheet for skin application and its manufacturing method |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2016216989A JP6809145B2 (en) | 2016-11-07 | 2016-11-07 | Adhesive sheet for skin application and its manufacturing method |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2018075057A true JP2018075057A (en) | 2018-05-17 |
| JP6809145B2 JP6809145B2 (en) | 2021-01-06 |
Family
ID=62149532
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016216989A Active JP6809145B2 (en) | 2016-11-07 | 2016-11-07 | Adhesive sheet for skin application and its manufacturing method |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JP6809145B2 (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2020158697A1 (en) * | 2019-01-28 | 2020-08-06 | 日東電工株式会社 | Adhesive skin patch material |
| CN114305869A (en) * | 2022-01-07 | 2022-04-12 | 福智医疗科技(苏州)有限公司 | Medical auxiliary material with sterilization and nourishing effects |
Citations (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH08224817A (en) * | 1993-11-02 | 1996-09-03 | Karayan Kk | Extensible surface decorative material |
| JP2000128780A (en) * | 1998-10-20 | 2000-05-09 | Sanyo Chem Ind Ltd | Cataplasm |
| JP2004527600A (en) * | 2001-02-21 | 2004-09-09 | コロプラスト アクティーゼルスカブ | Adhesive composition |
| JP2008541881A (en) * | 2005-05-27 | 2008-11-27 | ジョンソン・アンド・ジョンソン・コンシューマー・カンパニーズ・インコーポレイテッド | Isolated patches for viral diseases |
| US20100168633A1 (en) * | 2007-06-04 | 2010-07-01 | Chaabane Bougherara | Method for manufacturing two different patterned adhesive layers simultaneously |
| JP2010536823A (en) * | 2007-08-20 | 2010-12-02 | レスキン・エヌブイ | Breathable sheet material having adhesive coating layer and method for producing the same |
| WO2015119160A1 (en) * | 2014-02-05 | 2015-08-13 | アルケア株式会社 | Dermatological adhesive agent, patch material, and method for producing dermatological adhesive agent |
| US20160270965A1 (en) * | 2012-11-15 | 2016-09-22 | Colopast A?S | A wound dressing |
-
2016
- 2016-11-07 JP JP2016216989A patent/JP6809145B2/en active Active
Patent Citations (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH08224817A (en) * | 1993-11-02 | 1996-09-03 | Karayan Kk | Extensible surface decorative material |
| JP2000128780A (en) * | 1998-10-20 | 2000-05-09 | Sanyo Chem Ind Ltd | Cataplasm |
| JP2004527600A (en) * | 2001-02-21 | 2004-09-09 | コロプラスト アクティーゼルスカブ | Adhesive composition |
| JP2008541881A (en) * | 2005-05-27 | 2008-11-27 | ジョンソン・アンド・ジョンソン・コンシューマー・カンパニーズ・インコーポレイテッド | Isolated patches for viral diseases |
| US20100168633A1 (en) * | 2007-06-04 | 2010-07-01 | Chaabane Bougherara | Method for manufacturing two different patterned adhesive layers simultaneously |
| JP2010536823A (en) * | 2007-08-20 | 2010-12-02 | レスキン・エヌブイ | Breathable sheet material having adhesive coating layer and method for producing the same |
| US20160270965A1 (en) * | 2012-11-15 | 2016-09-22 | Colopast A?S | A wound dressing |
| WO2015119160A1 (en) * | 2014-02-05 | 2015-08-13 | アルケア株式会社 | Dermatological adhesive agent, patch material, and method for producing dermatological adhesive agent |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2020158697A1 (en) * | 2019-01-28 | 2020-08-06 | 日東電工株式会社 | Adhesive skin patch material |
| CN113316436A (en) * | 2019-01-28 | 2021-08-27 | 日东电工株式会社 | Skin adhesive material |
| JP7473485B2 (en) | 2019-01-28 | 2024-04-23 | 日東電工株式会社 | Skin patches |
| CN114305869A (en) * | 2022-01-07 | 2022-04-12 | 福智医疗科技(苏州)有限公司 | Medical auxiliary material with sterilization and nourishing effects |
Also Published As
| Publication number | Publication date |
|---|---|
| JP6809145B2 (en) | 2021-01-06 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| US9926470B2 (en) | Hybrid material of crosslinked microgel particles dispersed in an adhesive | |
| JP5005277B2 (en) | Patches and patch preparations | |
| JP5568133B2 (en) | Multilayer transdermal patch | |
| EP1569698B1 (en) | Absorbent multilayer hydrogel wound dressings | |
| JP2011236379A (en) | Pressure sensitive adhesive composition, and laminate using the same | |
| JP2009242807A (en) | Hot melt adhesive for dermal application | |
| US11375771B2 (en) | Disposable insole pads and use thereof | |
| US20150196515A1 (en) | Multi-Layer Drug Delivery System | |
| JP5592158B2 (en) | Cooling sheet and cooling method | |
| CN1907273B (en) | Production method of nicotine transdermal preparation | |
| CN101404967B (en) | Adhesive sheet article | |
| US20140242149A1 (en) | High-Viscosity Silicone Adhesive | |
| JP6809145B2 (en) | Adhesive sheet for skin application and its manufacturing method | |
| JP5185509B2 (en) | Patch | |
| JP5246838B2 (en) | Keratin peeling adhesive composition and keratin peeling adhesive sheet | |
| JPWO2018025895A1 (en) | SUPPORT FILM FOR TAPE MATERIAL, TAPE MATERIAL, AND METHOD FOR PRODUCING SUPPORT FILM FOR TAPE MATERIAL | |
| JP2013035975A (en) | Laminate | |
| US6703043B1 (en) | Substance release device | |
| JP2008056805A (en) | Adhesive sheet and method for peeling the same | |
| TW202038922A (en) | Tape or sheet for skin attachment | |
| JP2005314618A (en) | Skin-patch pressure-sensitive adhesive composition and skin patch material given by using the skin-patch pressure-sensitive adhesive composition | |
| WO2005030897A1 (en) | Adhesive and thermal material stuck in use produced therewith | |
| JP4638480B2 (en) | Medical bandage for application on the skin | |
| JP5000910B2 (en) | Patch and method for producing the same | |
| JP6149221B2 (en) | Foam adhesive sheet |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| A621 | Written request for application examination |
Free format text: JAPANESE INTERMEDIATE CODE: A621 Effective date: 20190710 |
|
| A711 | Notification of change in applicant |
Free format text: JAPANESE INTERMEDIATE CODE: A711 Effective date: 20190823 |
|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A821 Effective date: 20190823 |
|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A821 Effective date: 20190924 |
|
| A977 | Report on retrieval |
Free format text: JAPANESE INTERMEDIATE CODE: A971007 Effective date: 20200710 |
|
| A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20200908 |
|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20201023 |
|
| TRDD | Decision of grant or rejection written | ||
| A01 | Written decision to grant a patent or to grant a registration (utility model) |
Free format text: JAPANESE INTERMEDIATE CODE: A01 Effective date: 20201110 |
|
| A61 | First payment of annual fees (during grant procedure) |
Free format text: JAPANESE INTERMEDIATE CODE: A61 Effective date: 20201123 |
|
| R151 | Written notification of patent or utility model registration |
Ref document number: 6809145 Country of ref document: JP Free format text: JAPANESE INTERMEDIATE CODE: R151 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| S533 | Written request for registration of change of name |
Free format text: JAPANESE INTERMEDIATE CODE: R313533 |
|
| R350 | Written notification of registration of transfer |
Free format text: JAPANESE INTERMEDIATE CODE: R350 |