JP2018068945A - Article processing system - Google Patents

Abstract

SOLUTION: A filling device 3 is arranged in a clean room 2 and a clean booth 5 which covers the same from a top and of which a lower end part 5A opened is arranged. In the clean room 2, a seal wall 11 enclosing the filling device 3 and the clean booth 5 to be sealed state is arranged and an inner side of the seal wall 11 is a decontamination target region Z1. In an outer side of the seal wall 11, a decontamination gas supply means 13 for supplying decontamination gas to the decontamination target region Z1 is arranged. By supplying the decontamination gas G from the decontamination gas supply means 13 to the decontamination target region Z1 in a step before production by the filling device 3, insides of the filling device 3 and the clean booth 5 can be locally decontaminated.EFFECT: Inside of a clean booth 5 and a filling device 3 can be decontaminated and sterilized without stopping air conditioning installation for a clean room 2.SELECTED DRAWING: Figure 2

Description

  The present invention relates to an article processing system, and more particularly, to an article processing system capable of locally sterilizing a container processing apparatus disposed in a clean room.

2. Description of the Related Art Conventionally, there has been known an article processing system in which a container processing apparatus is disposed in a clean room, and the container processing apparatus is covered with a hermetic clean booth so that the clean booth is sterilized (for example, a patent). Reference 1).
Further, as shown in a simplified manner in FIG. 5, as a conventional article processing system 1, a container processing device 3 such as a filling device is disposed in a clean room 2, and the lower end 5 </ b> A of the container processing device 3 is opened. A configuration surrounded by an unsealed clean booth 5 from above is also known.

Japanese Patent No. 4573321

By the way, in the conventional article processing system 1 having the non-sealed clean booth 5 as shown in FIG. 5, the environment of the container processing apparatus 3 in the clean booth 5 is at the same level of microorganism management as the clean room 1. Can only be maintained. That is, the container processing apparatus 3 arranged in the grade B clean room 1 cannot be maintained at a microorganism management level of grade B or higher. Therefore, when it is desired to bring the container processing device 3 to the grade A microorganism management level, it is necessary to decontaminate the entire clean room 1 in which the container processing device 3 is disposed and sterilize to the grade A level.
However, when decontaminating the inside of the clean room 1 in this way, it is necessary to stop the air conditioning equipment for the clean room. This is because, in general, air conditioning equipment is not provided in one clean room, but is also connected to other clean rooms, so that hydrogen peroxide gas during decontamination work is also supplied to other clean rooms. Become. If the other clean room that is in communication is stopped, the equipment arranged in the clean room must also be stopped. If decontamination is frequently performed, production efficiency deteriorates, which is not feasible.
On the other hand, it is conceivable to enclose the container processing apparatus 3 with a shroud in order to make the container processing apparatus 3 an isolator, that is, to partition the space for processing the container by the container processing apparatus 3 from the clean room. In some cases, the shroud cannot be installed due to the ceiling height or area of the container, and if the strength of the container processing apparatus itself does not support isolatorization, it is necessary to modify the container processing apparatus itself. For this reason, there has been a problem that all existing container processing apparatuses cannot be handled by using an isolator.

In view of the circumstances described above, the present invention includes an article processing apparatus that is disposed in a clean room and performs required processing on articles, and a non-sealed clean booth that is disposed in the clean room so as to cover the article processing apparatus. An article handling system comprising:
A sealed wall provided in the clean room and surrounding the article processing apparatus and the clean booth so as to be sealed, a decontamination gas supply means for supplying a decontamination gas to the inner side of the sealed wall, and the sealing An air supply means that is arranged on the inner side of the wall and supplies air from the upper side to the lower side; and an opening / closing door that is provided on the sealing wall and can be opened when necessary.
At the time of decontamination in the article processing apparatus and the clean booth, the decontamination gas is supplied to the inner side of the sealed wall from the decontamination gas supply means with the open / close door closed,
At the time of production by the article processing apparatus, the opening / closing door is opened to allow communication between the inner side of the sealed wall and the inside of the clean room which is further outward, and the inner side of the sealed wall by the air supply means When air is supplied to the air, the air is circulated from the inner side of the sealing wall to the clean room outside the sealing wall through the open / close door.

  According to such a configuration, the clean booth and the article processing apparatus in the clean room can be locally decontaminated and sterilized without stopping the air conditioning equipment for the clean room.

The block diagram which shows one Example of this invention. The figure which shows the state at the time of the decontamination of the Example shown in FIG. The figure which shows the state at the time of aeration of the Example shown in FIG. The figure which shows the state at the time of production of the Example shown in FIG. The schematic block diagram which shows a prior art.

Hereinafter, the present invention will be described with reference to the illustrated embodiment. In FIG. 1, an article processing system 1 includes a filling device 3 as an article processing device disposed in a clean room 2, and the filling device 3 serves as an article. The vial 4 is filled with a chemical solution.
The filling device 3 includes a filling valve 3A for filling a chemical solution. When empty vials 4 are sequentially supplied to the filling position below the filling valve 3A by the conveyor 7, the vial 4 is fed by the filling valve 3A. It is designed to be filled with chemicals.
The filling device 3 is surrounded by a clean booth 5 whose lower end 5A is opened, and a work glove 6 is provided at a predetermined position of the clean booth 5. An operator can insert a hand into the work glove 6 from the outside of the clean booth 5 to perform a required work in the clean booth 5.
The ceiling 8 for the clean booth 5 is arranged at a position lower than the ceiling 2A of the clean room 2 itself, and the upper end 5B of the clean booth 5 is connected to the ceiling 8 for the clean booth. Thereby, the filling device 3 is covered from the upper side by the clean booth 5 and the ceiling 8 covering the outer side. On the other hand, the lower end 5A of the clean booth 5 does not reach the floor 2B of the clean room, and is positioned slightly below the conveyor 7 of the filling device 3. That is, the clean booth 5 covers the filling device 3 and the conveyor 7, but the lower end 5 </ b> A is open, so the inside of the clean booth 5 is in an unsealed state.

In the present embodiment, on the assumption that the non-sealed clean booth 5 is provided in the clean room 2, the sealing wall 11 is enclosed by the sealing wall 11 so that the filling device 3 and the cree booth 5 are sealed from the outside. This is characterized in that the inside of the decontamination target area Z1 which is the inside of the can be locally decontaminated.
That is, the article processing system 1 according to the present embodiment includes a clean room 2 having a large casing that can be sealed, the filling device 3 disposed in the center of the clean room 2, and the above-described filling device 3. Unsealed clean booth 5, sealing wall 11 surrounding the filling device 3 and clean booth 5 so as to be sealed from the outside, decontamination target region Z1 consisting of the internal space of the sealing wall 11, and decontamination An air supply means 12 for supplying air to the target area Z1 from above and a decontamination gas supply means 13 for supplying a decontamination gas G (hydrogen peroxide gas) to the decontamination target area Z1 at the time of decontamination are provided. .

The ceiling 8 for the clean booth is extended by a predetermined amount outward in the horizontal direction, and a sealing wall 11 is provided across the ceiling 8 'serving as the extension and the floor 2B of the clean room 2, and this sealing wall 11 is located on the outer side surrounding the clean booth 5 and away from the clean booth 5 by a required amount.
The inner wall can be maintained in a sealed state by the sealed wall 11, and the inner space of the sealed wall 11 including the inside of the clean booth 5 is a decontamination target region Z <b> 1. The sealing wall 11 is provided with an opening / closing door (not shown) for an operator to enter and exit the decontamination target area Z1, and when necessary, the operator opens and closes the opening / closing door to enter the decontamination target area Z1. You can enter and work. That is, a region between the clean booth 5 and the sealing wall 11 in the decontamination target region Z1 is a work region Z2 where an operator enters.

A first opening / closing door D1 is provided at the lower part of the sealing wall 11, and a second opening / closing door D2 is provided at the lower part of the sealing wall 11 which is the opposite position.
When the first opening / closing door D1 and the second opening / closing door D2 are opened when necessary, the decontamination target area Z1 that is the internal space of the sealing wall 11 and the internal area Z3 of the clean room 2 that is outside the sealing wall 11 are formed. Can communicate. On the other hand, when the first opening / closing door D1 and the second opening / closing door D2 are closed, the communication between the decontamination target area Z1 that is the internal space of the sealing wall 11 and the internal area Z3 is blocked, and the decontamination target area. Z1 is hermetically sealed.
A catalyst 14 is disposed on the inner side adjacent to the opening provided with the second opening / closing door D2. With the second opening / closing door D2 opened, the gas in the decontamination target area Z1 comes into contact with the catalyst 14 when flowing into the internal area Z3 via the second opening / closing door D2.

Next, the decontamination gas supply means 13 is arranged in the internal region Z3 in the clean room 2. The decontamination gas supply means 13 includes a decontamination gas generator 16 that generates the decontamination gas G, a supply pipe 17 that connects the sealed wall 11 (decontamination target region Z1) and the decontamination gas generator 16, A discharge pipe 18 that connects the sealed wall 11 (decontamination target region Z1) and the decontamination gas generator 16 is provided. A first on-off valve V1 is provided in the middle of the supply pipe 17, and a second on-off valve V2 and a blower B1 are provided in the middle of the discharge pipe 18. The operations of the first on-off valve V1, the second on-off valve V2 and the blower B1 are controlled by a control device (not shown).
When the decontamination gas G (hydrogen peroxide gas) is generated by the decontamination gas generator 16, when the first on-off valve V1 and the second on-off valve V2 are opened and the blower B1 is operated, The decontamination gas G is supplied to the decontamination target area Z1 via the supply pipe 17, and the gas in the decontamination target area Z1 is recovered by the decontamination gas generator 16 via the discharge pipe 18 and the blower B1. It has become.
If the decontamination gas G is supplied to the decontamination target area Z1 by the decontamination gas supply means 13 in the state where the decontamination target area Z1 is sealed, the clean booth 5 from the lower end portion 5A of the clean booth 5 via the work area Z2. The decontamination gas G also circulates inside. Therefore, the clean booth 5 and the filling device 3 are also decontaminated by the decontamination gas G.
An air conditioning filter 21 is provided on the side wall and the ceiling 2A of the clean room 2 facing the internal region Z3, and air is supplied to the internal region Z3 from an air conditioning facility (not shown) via the air conditioning filter 21 on the ceiling 2A side. The air in the internal region Z3 is discharged to the outside of the clean room 2 through the air conditioning filter 21 on the side wall. The air supplied from the air conditioning equipment to the internal region Z3 is managed so as to have a predetermined pressure and a predetermined microorganism management level.

In the present embodiment, a partition wall 25 is provided across the upper end portion 11A of the sealing wall 11 and the ceiling 2A of the clean room 2 so as to enclose the region above the decontamination target region Z1 in a sealed state. A third opening / closing door D3 and a fourth opening / closing door D4 are provided at predetermined positions of the partition wall 25.
The partition wall 25 blocks communication between the internal region Z4 and the internal region Z3 of the clean room 2, and when the third open / close door D3 and the fourth open / close door D4 are opened when necessary, the internal region Z4 and the internal region The area Z3 communicates with the area Z3.
Moreover, the pre filter 26 is provided in each opening part which provided the 3rd opening-and-closing door D3 and the 4th opening-and-closing door D4. This prevents dust from entering the internal region Z4.
Furthermore, in order to supply air into the decontamination target area Z1 when necessary, an air supply means 12 is provided in the internal area Z4.
The air supply means 12 includes two air supply HEPA filters 22 provided on the ceiling 8 of the clean booth 5, two air supply HEPA filters 23 provided on the ceiling 8 ′ of the extended portion, and each of the HEPA filters 22, 23. And an air supply pipe 24 for connecting the blowers B2 to B5. The operations of the blowers B2 to B5 are controlled by a control device (not shown), and an intake port (not shown) is arranged facing the internal region Z4.

The article processing system 1 according to the present embodiment is configured as described above. First, the inside of the decontamination target area Z1 is decontaminated, and then the aeration is performed, and then the filling operation (production) by the filling device 3 is performed. It has become. Hereinafter, the detail of the operation | movement at each of these work processes is demonstrated.
First, at the time of decontamination, as shown in FIG. 2, the doors D1 to D4 are closed and the air supply means 12 is not operated, that is, the decontamination target area Z1 and the air supply means 12 are In the state where the arranged internal region Z4 is sealed, the first on-off valve V1 and the second on-off valve V2 of the decontamination gas supply means 13 are opened and the blower B1 is operated. At this time, the decontamination gas G has already been generated by the decontamination gas generator 16. For this reason, the decontamination gas G is supplied into the decontamination target area Z1 via the supply pipe 17, and at the same time, the gas within the decontamination target area Z1 is discharged via the discharge pipe 18. The decontamination gas G is first supplied into the work area Z <b> 2 and then supplied from the lower end 5 </ b> A of the clean booth 5 to the internal space of the clean booth 5. Thus, since the decontamination gas G is supplied to the entire area within the decontamination target area Z1, the clean booth 5 and the filling device 3 are decontaminated to the grade A microorganism control level. That is, the inside of the clean booth 5 and the work area Z2 are both decontaminated to the grade A microorganism control level.
At the time of this decontamination, a predetermined pressure and air of a microorganism management level are supplied from the air conditioning equipment to the internal region Z3 of the clean room 2 outside the decontamination target region Z1. The microbe management level of the air is grade B lower than the grade A. As described above, in this embodiment, the clean booth 5 and the filling device 3 in the decontamination target area Z1 are set at the microbial management level without stopping the air conditioning equipment for the internal area Z3 of the clean room 2 in an operating state. It can be decontaminated locally with high grade A.
In this way, the decontamination gas G is supplied into the decontamination target area Z1 for the required time, and the inside of the filling device 3 and the clean booth 5 is decontaminated.

Next, when the decontamination process ends, aeration of the decontamination target area Z1 is performed thereafter. That is, as shown in FIG. 3, first, the blowers B2 to B5 of the air supply means 12 are operated in synchronization, and the first opening / closing door D1 remains closed, and the second opening / closing door D2 and the third opening / closing door D3. And the 4th opening-and-closing door D4 is open | released. On the other hand, the first on-off valve V1 and the second on-off valve V2 of the decontamination gas supply means 13 are closed, the operation of the blower B1 is stopped, and the operation of the decontamination gas generator 16 is also stopped.
When each of the blowers B2 to B5 of the air supply means 12 is operated in this state, the third open / close door D3 and the fourth open / close door D4 are opened, so that the air above the internal region Z3 is in the internal region Z4. And is supplied to the clean booth 5 and the work area Z2 (the entire area of the decontamination target area Z1) in a state where impurities are removed by the HEPA filters 22 and 23 together with the air in the internal area Z4.
In the decontamination target area Z1, since the second opening / closing door D2 is opened, the gas (decontamination gas G) in the decontamination target area Z1 is detoxified by the catalyst 14 to the outside of the decontamination target area Z1. It is discharged to the internal area Z3 of the clean room 2.
At the time of this aeration, air is supplied with the same air supply amount in the clean booth 5 and the work area Z2 in the decontamination target area Z1.
In addition, aeration is performed until a predetermined time elapses, and the decontamination target area Z1 is grade A of the microorganism management level through the decontamination process and the aeration process.

Next, when aeration is completed, a filling operation (production) by the filling device 3 is started. At the time of transition to production after aeration, as shown in FIG. 4, the first door D1 closed at the time of aeration is opened, and all the doors D1 to D4 are opened. Further, the decontamination gas supply means 13 is stopped.
During the filling operation, the air supply amount (X1) supplied to the clean booth 5 by the blowers B2 and B3 and the air supply amount (X2) supplied to the work area Z2 by the blowers B4 and B5 are: The air supply amount (X1) supplied to the clean booth 5 is set to be larger than the air supply amount (X2) supplied to the work area Z2, and the air supplied into the clean booth 5 is supplied to the work area Z2. And the gas in the decontamination target area Z1 is set to be discharged toward the internal area Z3 of the clean room 2 through the first opening / closing door D1 and the second opening / closing door D2. Yes.
In this state, empty vials 4 are sequentially supplied to the filling position below the filling valve 3A by the conveyor 7, so that the liquid medicine is filled into the vials 4 by the filling valve 3A. At the time of production, the operator can open and close a door (not shown) when necessary, enter the work area Z2 and perform the required work through the work glove 6. Since the air supply amount in the work area Z2 is smaller than the air supply amount into the clean booth 5, the atmosphere in the work area Z2 enters the clean booth 5 even if the worker enters the work area Z2 and works. The filling device 3 is not contaminated.

As described above, in the present embodiment, on the assumption that existing facilities (clean booth 5 and filling device 3) are arranged in the clean room 2, they can be decontaminated and sterilized locally. . And at the time of decontamination, it is not necessary to stop the air-conditioning equipment for the clean room 2.
Further, in this embodiment, on the premise of the article processing system 1 equipped with existing equipment, a sealed wall 11 and a decontamination gas supply means 13 are added, and the clean booth 5 is decontaminated locally. A possible small article processing system 1 can be provided.
Further, during the production by the filling device 3, since the air supply amount into the clean booth 5 is set to be larger than the air supply amount in the work area Z2, an operator enters the work area Z2 and works. However, the clean booth 5 and the filling device 3 are not contaminated.
In addition, although the said Example assumes the filling apparatus 3 which fills a container (vial 4) with a chemical | medical solution as an article processing apparatus, as an article processing apparatus, it is required with respect to articles other than a container, for example, a box, a semiconductor, etc. It may be a device that performs processing.

DESCRIPTION OF SYMBOLS 1 ... Article processing system 2 ... Clean room 3 ... Filling device (article processing device) 4 ... Vial (article)
5. Clean booth 11. Sealed wall 12. Air supply means 13. Decontamination gas supply means G ... Decontamination gas Z1 ... Decontamination target area

Claims (2)

An article processing system provided with an article processing apparatus that is disposed in a clean room and performs required processing on articles, and an unsealed clean booth that is disposed in the clean room so as to cover the article processing apparatus,
A sealed wall provided in the clean room and surrounding the article processing apparatus and the clean booth so as to be sealed, a decontamination gas supply means for supplying a decontamination gas to the inner side of the sealed wall, and the sealing An air supply means that is arranged on the inner side of the wall and supplies air from the upper side to the lower side; and an opening / closing door that is provided on the sealing wall and can be opened when necessary.
At the time of decontamination in the article processing apparatus and the clean booth, the decontamination gas is supplied to the inner side of the sealed wall from the decontamination gas supply means with the open / close door closed,
At the time of production by the article processing apparatus, the opening / closing door is opened to allow communication between the inner side of the sealed wall and the inside of the clean room which is further outward, and the inner side of the sealed wall by the air supply means By supplying air to the article processing system, the air is circulated from the inner side of the sealing wall to the clean room outside the sealing wall through the open / close door. The amount of air supplied to the inside of the sealed wall by the air supply means is such that the amount of air supplied into the clean booth is larger than the amount of air supplied to the area between the clean booth and the sealed wall. The article processing system according to claim 1, wherein the article processing system is set to increase.

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