JP2018057706A - Cap for drug solution container and drug solution container including the cap - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide a cap for a drug solution container that is readily manufactured and has a rubber cap prevented from easily coming off.SOLUTION: A cap 100 for a drug solution container is configured such that a rubber cap 30 capable of being punctured by an injection needle N is connected to a synthetic resin cylindrical cap body 20 in a liquid tight manner. The cap 100 for a drug solution container is obtained by insert molding the rubber cap 30 into the cap body 20. The rubber cap 30 has an annular groove part 33 for encompassing an inner flange 22c.SELECTED DRAWING: Figure 2

Description

  The present invention relates to a chemical liquid container cap and a chemical liquid container having the cap.

  The cap for the chemical solution container comprises a cylindrical cap body made of a synthetic resin that is fixed in a liquid-tight manner at the inlet of the chemical solution container filled with the chemical solution, and a rubber cap that can be punctured with an injection needle (hereinafter referred to as a rubber cap). It is constructed by liquid-tight coupling. When using a chemical solution, a rubber cap is pierced with an injection needle to suck the chemical solution in the chemical solution container.

  Taking an infusion container (infusion pack) as an example of a chemical container, the cap body and the rubber cap are conventionally sealed by being plugged with an opening rubber stopper of the container (Patent Document 1) or The cylindrical cap body is divided into two parts in the axial direction, and the two-part cap body is welded (generally ultrasonically welded) with a rubber cap sandwiched between the two-part cap bodies. (Patent Documents 2 and 3).

JP 2011-93586 Japanese Unexamined Patent Publication No. 2004-49598 JP-A-8-33698

  In a conventional chemical solution container cap, it is difficult to use a two-part cap body such as an infusion container cap, both in the molding operation and in the welding operation, and the cost increases. Moreover, when welding is inadequate, it cannot endure use. Furthermore, since the split cap body and the rubber cap are molded separately, if the dimensions vary during molding, the split cap body is welded with the rubber cap sandwiched between the split cap bodies. Even if it uses as a cap for chemical | medical solution containers, since a clearance gap arises between a bipartite cap and a rubber cap and sufficient adhesion | attachment is not obtained, there exists a possibility that a chemical | medical solution may leak. If an adhesive is interposed between the two-part cap body and the rubber cap, the adhesive mixes with the chemical solution, which may adversely affect the original drug efficacy of the chemical solution.

  It is an object of the present invention to obtain a chemical solution container cap that is particularly suitable for use in a small chemical solution container and that is easy to manufacture and in which a rubber cap does not easily fall off. In addition, although this invention is suitable for using for the cap for small chemical | medical solution containers, it is not the meaning limited to a small thing.

  The present invention is a chemical solution container cap in which a rubber cap capable of puncturing an injection needle is liquid-tightly coupled to a cylindrical cap body made of a synthetic resin, and the rubber cap is insert-molded in the cap body It is characterized by that.

  Preferably, the cap body has an inner flange, and the rubber cap has an annular groove that wraps around the inner flange.

  The rubber cap is preferably made of silicone rubber.

When the inner diameter of the inner flange is d and the upper and lower outer diameters of the inner flange of the rubber cap are D,
0.4 ≦ d / D ≦ 0.9
Is desirable.

  The cap body is preferably made of a thermoplastic resin material having a heat resistant temperature of 100 ° C. or higher.

When the outer diameter of the injection needle that punctures the rubber cap is Nd,
0.18 ≦ Nd / d ≦ 0.41
It is desirable that

  The chemical liquid container of the present invention is a chemical liquid container in which the above-mentioned chemical liquid container cap is integrally coupled or integrally formed.

  The cap for a chemical container of the present invention is formed by inserting a rubber cap into a cylindrical cap body made of a synthetic resin, so that it is easy to manufacture and the rubber cap is a thermosetting type. Since the contact force is increased by the contraction action and the flange portion is deformed so as to surround the flange portion, there is no possibility that the rubber cap is detached from the cap body when the injection needle is inserted. Moreover, since it can manufacture without interposing an adhesive agent between a cap main body and a rubber cap, there is no possibility that a chemical | medical solution will be contaminated with an adhesive agent.

It is a top view of one Embodiment of the cap for chemical | medical solution containers by this invention. It is sectional drawing which follows the II-II line of FIG. It is sectional drawing corresponding to FIG. 2 which shows the state of insert molding of the cap for chemical | medical solution containers of FIG.

  1 and 2 show an embodiment of a chemical solution container cap 100 according to the present invention. The chemical solution container cap 100 has a cylindrical cap body 20 made of a synthetic resin material that is liquid-tightly fixed to the cylindrical mouth portion 11 of the chemical liquid container 10 and one end portion (upper end portion in the figure) of the cap main body 20. It is composed of a rubber cap (elastomer cap) 30 formed by insert molding. The basic shape of the chemical solution container cap 100 (cap body 20) of this embodiment is a rotationally symmetric shape with the axis O as the center, and the synthetic resin material is, for example, selected from thermoplastic resins. Specific materials for the rubber cap 30 will be described in detail later.

  The cap body 20 (chemical solution container cap 100) of the present embodiment is a small one having an outer diameter of about 6.5 mm and a height of about 10 mm, for example, and the outer periphery of the cylindrical mouth portion 11 of the chemical solution container 10. A simple cylindrical portion 21 that is attached (fitted) and fixed thereto, and a cap molding portion (cap molding space) 22 connected to the simple cylindrical portion 21. The simple cylinder portion 21 has a constant inner diameter X, and wing-like projections 21a for defining the direction with the cap body 20 at the time of rubber molding are formed at two lower portions of the outer surface in the diametrical direction. ing.

  The cap molding portion 22 includes a small-diameter cylindrical portion 22a having a smaller diameter than the inner diameter of the simple cylindrical portion 21, and an enlarged diameter stepped portion 22b is formed at the end of the small-diameter cylindrical portion 22a on the simple cylindrical portion 21 side. Yes. An inward flange 22c is formed in the middle of the small-diameter cylindrical portion 22a in the axial direction, and the small-diameter cylindrical portion 22a is formed at two opposite ends in the diametrical direction at the end opposite to the simple cylindrical portion 21. A gate forming recess 22d is formed in communication with the. The outer surface of the cap molding part 22 forms a tapered cylindrical part 22t. The small diameter cylindrical portion 22a may have a tapered shape that expands upward in the drawing, and the tapered cylindrical portion 22t may have a simple cylindrical shape.

  Now, assuming that the small diameter cylindrical portion 22a (on the simple cylindrical portion 21 side) below the inner flange 22c is the lower small diameter cylindrical portion 22a (1) and the upper small diameter cylindrical portion 22a is the upper small diameter cylindrical portion 22a (2), In the illustrated example, the diameter (D) of both is the same, and the inner diameter of the inner flange 22c is d (d <D). The diameters of the lower small diameter cylindrical portion 22a (1) and the upper small diameter cylindrical portion 22a (2) may be different.

  The rubber cap 30 made of a thermosetting material is insert-molded so as to wrap the inner flange 22c in the cap molding portion 22 of the cap body 20 described above. That is, the rubber cap 30 has an upper and lower large-diameter portion 31 corresponding to the upper and lower small-diameter cylindrical portions 22a of the cap molding portion 22, and a small-diameter portion 32 corresponding to the inner flange 22c. An annular groove (a U-shaped section) 33 is formed by the intermediate small diameter portion 31 and 31. Further, the protruding elastomer 34 formed at the time of insert molding is located in at least a part of the gate forming recess 22d (in FIG. 2, the protruding elastomer 34 is drawn in all of the gate forming recess 22d. ). An injection needle guide recess 35 is formed on the end surface of the rubber cap 30 opposite to the cylindrical mouth portion 11 so as to be positioned at the shaft portion. The guide recess 35 is a plane circle (FIG. 1) and a quadrangle (FIG. 2), but may be a plane polygon and may be a triangle or a bottom R shape.

  FIG. 3 shows an example of the mold configuration of the lower mold 40 and the upper mold 50 for insert-molding the rubber cap 30 into the cap molding portion 22 of the cap body 20. The cap body 20 made of synthetic resin is prepared by molding in the shape shown in FIGS. The lower mold 40 has a columnar part 41 that fits into the simple cylindrical part 21 of the cap body 20 and abuts on the enlarged diameter stepped part 22b, and an annular space (cylindrical space) 42 on the outer periphery of the columnar part 41. . The upper mold 50 includes a mold space 51 that houses the cap molding portion 22 of the cap body 20 held by the columnar portion 41 of the lower mold 40, a concave portion forming protrusion 52 corresponding to the injection needle guide concave portion 35, and a cap molding portion. A liquid elastomer material injection port 53 is formed in one of the pair of gate forming recesses 22d. When the cap body 20 is set on the lower mold 40, the position in the rotation direction can be determined by the wing-like protrusion 21 a of the cap body 20.

  When the rubber cap 30 is insert-molded into the cap molding portion 22 of the cap body 20, the upper die 50 is opened, the cap body 20 is set in the columnar portion 41 of the lower die 40, and the upper die 50 as shown in FIG. 3. Is closed on the lower mold 40. When the liquid elastomer (liquid rubber material) is injected and solidified from the liquid elastomer injection port 53 into the cap molding portion 22 of the cap body 20 in the mold closed state, the chemical solution container cap 100 shown in FIGS. 1 and 2 is obtained. .

  This liquid elastomer injection molding is performed in a clean room using the applicant's LIM (Liquid Injection Molding) technology, so that the rubber cap 30 is not interposed between the cap body 20 and the rubber cap 30. Can be done without polluting. As shown in the figure, by forming a pair of (two or more) gate forming recesses 22d in the cap molding portion 22, when one (one) gate forming recess 22d is used as a liquid elastomer injection gate, the other The gate forming recess 22d can be used as a liquid elastomer escape space.

  Since the rubber cap 30 insert-molded in the cap molding portion 22 of the cap body 20 wraps the inner flange 22c with the annular groove portion 33, the cap body 20 and the rubber cap 30 are firmly coupled. can do. Therefore, the puncturing operation (and the operation of pulling out the injection needle N if necessary) for puncturing the injection needle injection needle N along the axis O of the rubber cap 30 using the injection needle guide recess 35 as a guide can be reliably performed.

Next, specific examples of dimensions of the diameter Nd of the injection needle N, each part of the cap molding part 22 (d (inner flange 22c) inner diameter, D (upper and lower outer diameters of the inner flange 22c of the rubber cap 30)). I'll give you.
Nd = 0.8mm
d = 2.0mm
D = 3.0mm

The preferred range of Nd / d is
0.18 ≦ Nd / d ≦ 0.41
It is.
When the upper limit of this conditional expression is exceeded, when the injection needle N is punctured into the rubber cap 30, the deformation of the rubber cap 30 becomes large and the rubber cap 30 is likely to drop off from the cap body 20. If the lower limit is not reached, the fitting force between the rubber cap 30 and the cap main body 20 becomes low, and the rubber cap 30 tends to drop off from the cap main body 20.

Moreover, the preferable range of d / D is
0.4 ≦ d / D ≦ 0.9
It is.
If the upper limit of this conditional expression is exceeded, the fitting force between the rubber cap 30 and the cap body 20 will be low, and the rubber cap 30 will easily fall off the cap body 20. If the lower limit is not reached, the strength of the cap molding part 22 is lowered, and the cap body 20 is difficult to mold.

  Further, the axial lengths of the large-diameter portion 31, the small-diameter portion 32, and the large-diameter portion 31 of the rubber cap 30 (the small-diameter cylindrical portion 22a (1), the inner flange 22c and the small-diameter cylindrical portion 22a (2) of the cap body 20) are set. When P, Q, and R are set, P≈Q≈R or P = R ≧ Q is preferable. In the illustrated example, P = 1.2 mm, Q = 1.0 mm, and R = 1.2 mm. By making the axial lengths of the small-diameter cylindrical portion 22a (1) and the small-diameter cylindrical portion 22a (2) equal to or greater than the axial length of the inner flange 22c, the rubber cap 30 sufficiently secures the inner flange 22c of the cap body 20. The effect which makes it difficult to drop off from the cap molding part 22 can be expected.

  The rubber cap 30 is particularly preferably made of liquid silicone rubber. There are mainly three reasons why liquid silicone rubber is preferred. One is the problem of temperature when vulcanizing. For example, butyl rubber has a vulcanization temperature of 150 ° C. or higher and a long vulcanization time (about 10 minutes), so that the cap body 20 is made of vinyl chloride resin (PVC), polystyrene (PS), polyethylene terephthalate (PET), low density polyethylene. If it is made of (LDPE) or the like, its heat-resistant temperature is lower than the vulcanization temperature of butyl rubber, and therefore, the cap body 20 may be melted when flowing into the cap molding portion 22 of the cap body 20. In contrast, liquid silicone rubber has a low vulcanization temperature of about 110 to 120 ° C. and a short vulcanization time (about 2 minutes), so even if the heat resistance temperature of the thermoplastic resin used for the cap body 20 is 100 ° C. It was confirmed that no melting problem occurred. As a suitable thermoplastic resin for the cap body 20, olefin-based thermoplastic elastomer (TPO), polypropylene (PP), polycarbonate (PC) or high-density polyethylene (HDPE) is desirable. Next, liquid silicone rubber is a clean material, and a cleaner cap for a chemical solution container can be obtained by insert molding in a clean room. Therefore, it is suitable as a drug (for example, for infusion) that extremely dislikes mixing of foreign substances. Further, if the silicone rubber is small, the weak point that the binding force is relatively weak does not manifest. It is understood that one of the reasons why butyl rubber has been mainly used heretofore is that it has a high binding force (leakage prevention force) when it is stabbed, regardless of its size. On the other hand, silicone rubber is said to have a relatively weak binding force. However, if the inner diameter of the inner flange 22c of the cap body 20 is as small as about 2.0 to 4.5 mm, such a problem occurs. Does not become apparent, and can be used sufficiently.

  Further, when both the cap body 20 and the rubber cap 30 (silicone rubber) are transparent, the punctured injection needle can be visually observed.

  The gate forming recess 22d formed in the cap body 20 may be single. However, if a pair of gate forming recesses 22d (with an interval of 180 °) opposed in the radial direction is formed as in the illustrated example, the direction of the cap body 20 can be selected at intervals of 180 ° during insert molding. Further, since the recess 22d not used as a gate can be a relief portion of the liquid material, it is preferable that the number is two or more. If the gate forming recesses 22d are formed at 90 ° intervals, the degree of freedom in the direction of the cap body 20 is further increased.

  The resin material constituting the cap body 20 is a thermoplastic resin having a heat resistant temperature of 100 ° C. or higher, and the rubber material constituting the rubber cap 30 is a liquid silicone rubber having a vulcanization temperature of about 110 to 120 ° C. The optimal combination.

  In the above embodiment, the basic shape (excluding the wing-like protrusion 21a and the gate forming recess 22d) of the cap body 20 (chemical solution container cap 100) is a rotationally symmetric shape with the axis O as the center. It is also possible to form a rectangular tube. The inner flange 22c does not necessarily have a rotationally symmetric shape, and may be discontinuous in the circumferential direction.

DESCRIPTION OF SYMBOLS 100 Chemical solution container cap 10 Chemical solution container 11 Cylindrical mouth part 20 Cap main body 21 Simple cylinder part 21a Wing-like protrusion 22 Cap molding part (cap molding space)
22a Small diameter cylindrical portion 22b Wide diameter stepped portion 22c Inner flange 22d Gate forming concave portion 22t Tapered cylindrical portion 30 Rubber cap 31 Large diameter portion 32 Small diameter portion 33 Projection elastomer 35 Injection needle guide concave portion N Injection needle 40 Lower mold 41 Columnar part 42 Annular space 50 Upper mold 51 Mold space 52 Recessed projection 53 Liquid elastomer injection port O Axis

Claims (7)

It is a cap for a chemical liquid container in which a rubber cap capable of puncturing an injection needle is liquid-tightly coupled to a cylindrical cap body made of a synthetic resin,
A cap for a chemical solution container, wherein the rubber cap is insert-molded in the cap body. 2. The chemical liquid container cap according to claim 1, wherein the cap body has an inner flange, and the rubber cap has an annular groove portion that wraps around the inner flange. 3. The chemical liquid container cap according to claim 1, wherein the rubber cap is made of silicone rubber. In the chemical solution container cap according to claim 2 or 3, when the inner diameter of the inner flange is d, and the upper and lower outer diameters of the inner flange of the rubber cap are D,
0.4 ≦ d / D ≦ 0.9
Cap for chemical container. The chemical | medical solution container cap of any one of Claim 1 thru | or 4 WHEREIN: The said cap main body is a chemical | medical solution container cap which consists of a thermoplastic resin material with a heat resistant temperature of 100 degreeC or more. The cap for a medical solution container according to claim 4 or 5, wherein the outer diameter of the injection needle that punctures the rubber cap is Nd,
0.18 ≦ Nd / d ≦ 0.41
Cap for chemical container. A chemical solution container in which the cap for a chemical solution container according to any one of claims 1 to 6 is integrally coupled or integrally formed.

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