JP2018030817A - Insect repellent - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide an insect repellent that has excellent repellent activity and is highly safe.SOLUTION: An insect repellent contains 2-methoxy-4-propylphenol and marjoram oil as active ingredients.SELECTED DRAWING: None

Description

  The present invention relates to an insect repellent having repellent activity against insects.

  Many blood-sucking insects transmit pathogens to people and animals to cause infections and cause skin inflammation. In particular, mosquitoes are hygienic and extremely harmful insects because they carry serious diseases such as dengue fever, zika fever, yellow fever, encephalitis and malaria.

  These insects are a thermal sensor that senses the body temperature of animals, a taste receptor that senses taste, an olfactory receptor that senses volatile substances such as body odor, and a carbon dioxide receptor that senses carbon dioxide, which is a highly volatile substance. Possesses an excellent chemoreceptive system, and takes various actions. For example, female mosquitoes seek blood before spawning, follow the carbon dioxide and body odor that animals exhale through breathing, approach the animal, detect the target animal by detecting the body temperature with a thermal sensor, and know that it sucks blood It has been.

In recent years, a means for repelling insects has been devised by changing the chemoreceptive system of such insects to neutralize the cognitive sensation of insects, and N, N-diethyl-3-methylbenzamide (DEET) and Substances acting on olfactory receptors such as p-menthane-3,8-diol (PMD) are used as repellents. However, DEET has an unpleasant odor and has a problem that its use is limited for infants and people with sensitive skin due to its high skin penetration, and the duration is 2-3 hours. .
Further, it has been reported that natural essential oils such as lemon eucalyptus oil, lemongrass oil, orange oil, and cassia oil have a flying insect repellent effect (for example, Patent Document 1), but the repellent effect is not always sufficient. However, there is a problem in its practicality.

  On the other hand, 2-methoxy-4-propylphenol (dihydroeugenol) used in the present invention is a compound having a scent similar to eugenol and used as a fragrance. This compound has been reported to have antibacterial activity against periodontal disease and caries-causing bacteria (Patent Document 2). In addition, marjoram (Origanum majora) is a perennial plant of the family Lamiaceae, and its essential oil, marjoram oil, is generally used for the purpose of calming, anxiety, etc., but it has also been reported to have a repellent effect against aphids. (Patent Document 3).

Japanese Patent Laid-Open No. 2002-173407 JP 2002-265978 A JP-A-9-110623

  The present invention relates to providing an insect repellent having excellent repellent activity and high safety.

  As a result of searching for materials that suppress the attracting behavior of insects to the human body, the present inventor has an excellent attracting behavior suppressing effect by using 2-methoxy-4-propylphenol and marjoram oil in combination, and is an insect repellent. As found useful.

That is, the present invention relates to the following 1) to 2).
1) An insect repellent containing 2-methoxy-4-propylphenol and marjoram oil as active ingredients.
2) An insect repellent method in which 2-methoxy-4-propylphenol and marjoram oil are applied to the skin of a mammal.

  ADVANTAGE OF THE INVENTION According to this invention, the insect repellent which shows the effect which suppresses the attracting action to the human body of an insect, and has high safety | security can be provided.

The graph which shows the attraction rate (average value ± SD.) Of the mosquito to the human hand.

  The 2-methoxy-4-propylphenol of the present invention is also referred to as dihydroeugenol, and is a fragrance compound having a scent similar to that of eugenol. 2-Methoxy-4-propylphenol is commercially available as a fragrance from SIGMA-ALDRICH, et al.

  The marjoram oil of the present invention is an essential oil obtained from Labiatae marjoram (scientific name: Origanum majorana). Marjoram oil can be produced by obtaining oil from the whole plant or leaves of marjoram by steam distillation, pressing, extraction or the like. Further, a steam distillate is commercially available from Naturally Vibrant Health Co., Ltd. and others, and the commercially available product can be used as it is.

  In the present invention, the target insects may be either blood-sucking or non-blood-sucking, and preferably include those equipped with a carbon dioxide accepting response system or a heat accepting system. For example, mosquitoes such as Culex mosquitoes, Culex mosquitoes, Aedes albopictus, Aedes albopictus, Aedes albopictus, houseflies, fruit flies, fly flies, sand flies, fly flies, fly fly, onion flies, fruit flies, fly flies, flies, etc. , Mosquitoes, chironomids, and the like. Among these, mosquitoes, flies, flyfish, and flies are preferable, and mosquito females are more preferable.

As will be described later in Examples, the combined use of 2-methoxy-4-propylphenol and marjoram oil of the present invention suppresses mosquito attracting behavior to the human body. Thus, the combination of 2-methoxy-4-propylphenol and marjoram oil can be an insect repellent and can be used to produce an insect repellent. That is, the combination of 2-methoxy-4-propylphenol and marjoram oil of the present invention can be used for insect repellent.
Here, “insect repellent” means that the insects are not brought close to the object, or the insects do not get close to the object. Different.
In the present invention, the mechanism of insect repellent is not particularly limited, and examples thereof include suppression of insect carbon dioxide response, suppression of heat reception response or heat reception. Here, “inhibition of insect carbon dioxide response” means that the carbon dioxide acceptance response of insects is neutralized or reduced to control the cognitive sensation of carbon dioxide and to suppress the attraction to carbon dioxide sources. means. Also, “suppression of heat reception response” or “heat reception suppression” means to disable or reduce the heat reception response of mosquitoes, to suppress the cognitive sensation to the heat source, and to suppress the attraction to the heat source. To do.

  The insect repellent of the present invention is applied to the skin of mammals including humans, adhered or held to apparel items such as clothes and accessories directly or indirectly in contact with the skin, indoors, in vehicles, etc. It is possible to repel insects by means such as spraying (including transpiration or volatilization) in a certain space, and other components such as solvents and various pharmaceutical additives are appropriately added depending on the mode of use. It can mix | blend and it can formulate as a composition. Further, the insect repellent of the present invention is used as a material for imparting insect repellent activity to a skin external preparation, a cleaning agent, a skin cosmetic, a hair cosmetic, a fabric softener, a fabric treating agent, and the like. May be.

  The blending amounts of 2-methoxy-4-propylphenol and marjoram oil in the composition are different depending on the form of the preparation, but each is preferably 0.001% by mass or more, more preferably 0.001% by mass relative to the total amount of the composition. 01% by mass or more, more preferably 0.1% by mass or more, and preferably 80% by mass or less, more preferably 40% by mass or less, still more preferably 10% by mass or less, or preferably 0.001. -80 mass%, more preferably 0.01-40 mass%, more preferably 0.01-10 mass%, preferably 0.001 mass% or more, more preferably 0.01 mass% or more, and even more preferably 0. .1% by weight or more, and preferably 80% by weight or less, more preferably 40% by weight or less, still more preferably 10% by weight or less, or The Mashiku 0.001 wt%, more preferably from 0.01 to 40 wt%, more preferably 0.01 to 10 mass%, more preferably from 0.1 to 10 mass%.

  The mixing ratio of 2-methoxy-4-propylphenol and marjoram oil can be selected as appropriate. For example, the marjoram oil is preferably about 0. 1 mass part of 2-methoxy-4-propylphenol. 01 parts by mass or more, more preferably 0.1 parts by mass or more, more preferably 0.2 parts by mass or more, and preferably 100 parts by mass or less, more preferably 10 parts by mass or less, more preferably 5 parts by mass. Or less. Moreover, Preferably it is 0.01-100 mass parts, More preferably, it is 0.1-10 mass parts, More preferably, it is 0.2-5 mass parts.

The type of the solvent or additive can be appropriately selected according to the usage pattern and purpose of the insect repellent. Examples of the solvent include lower alcohols such as methanol, ethanol, and propanol, and water.
Examples of additives include additives generally used in various chemical products, cosmetics, and the like. Specifically, surfactants, organic solvents, oil components, moisturizers, powders, solubilizers, additives. Examples include sticky agents, resins, cleaning agents, preservatives, ultraviolet absorbers, inorganic substances, fragrances, pigments, deodorants, essential oils, drugs, plant extracts, and other repellents.

  The formulation form of the insect repellent of the present invention may be appropriately set according to the use mode, and may be any of liquid, cream, lotion, emulsion, gel, ointment, powder, granule, spray, aerosol spray, etc. Good.

  When spraying the insect repellent of the present invention in a certain space, preferably the insect repellent is held in a carrier or dissolved in a solvent, filled in a container having a liquid absorbent core, and heated or blown away, or It is possible to employ means for holding an insect repellent on a carrier and allowing it to evaporate at room temperature. In this case, examples of the carrier material for supporting the insect repellent include natural fibers such as pulp, cotton, wool, hemp and silk; polypropylene, polyethylene, polyamide, polyethylene terephthalate, polybutylene terephthalate, polysulfone, rayon and methacrylic acid. Synthetic fibers such as resin and glass fiber; and porous materials such as zeolite, talc, white carbon, diatomaceous earth, lime, silica gel, activated carbon and the like.

  In addition, the insect repellent of the present invention can be attached to or held on apparel articles by applying the insect repellent to the target article, or by adding the insect repellent to the fabric softener and attaching or holding it during the softener treatment. Or treating various fabric substrates with an insect repellent in advance and using the fabric substrate imparted with insect repellent activity to produce a target article.

With respect to the above-described embodiment, the following aspects are disclosed in the present invention.
<1> An insect repellent containing 2-methoxy-4-propylphenol and marjoram oil as active ingredients.
<2> The insect repellent according to <1>, wherein the insect is one or more selected from mosquitoes, flies, flyfish and flies.
<3> The insect repellent of <2>, wherein the insect is a mosquito.
<4> An insect repellent method in which 2-methoxy-4-propylphenol and marjoram oil are applied to mammalian skin.

<5> Use of 2-methoxy-4-propylphenol and marjoram oil to produce an insect repellent.
<6> Use of 2-methoxy-4-propylphenol and marjoram oil to repel insects.
<7> The content of 2-methoxy-4-propylphenol in the composition is preferably 0.001% by mass or more, more preferably 0.01% by mass or more, and further preferably 0.1% by mass or more. And preferably 80% by mass or less, more preferably 40% by mass or less, further preferably 10% by mass or less, or preferably 0.001 to 80% by mass, more preferably 0.01 to 40% by mass, More preferably, it is 0.01-10 mass%, More preferably, it is 0.1-10 mass%, <1>-<3> insect repellent.
<8> The content of marjoram oil in the composition is preferably 0.001% by mass or more, more preferably 0.01% by mass or more, still more preferably 0.1% by mass or more, and preferably 80% by mass. % Or less, more preferably 40% by mass or less, still more preferably 10% by mass or less, or preferably 0.001 to 80% by mass, more preferably 0.01 to 40% by mass, more preferably 0.01%. The insect repellent according to <1> to <3>, <7>, which is from 10 to 10% by mass, more preferably from 0.1 to 10% by mass.
<9> The blending ratio of 2-methoxy-4-propylphenol and marjoram oil is preferably 0.01 parts by mass or more, more preferably with respect to 1 part by mass of 2-methoxy-4-propylphenol. 0.1 parts by mass or more, more preferably 0.2 parts by mass or more, and preferably 100 parts by mass or less, more preferably 10 parts by mass or less, more preferably 5 parts by mass or less, or preferably Is 0.01 to 100 parts by mass, more preferably 0.1 to 10 parts by mass, and more preferably 0.2 to 5 parts by mass, <1> to <3>, <7> to <8> insects Repellent.
<10> An insect repellent method in which 2-methoxy-4-propylphenol and marjoram oil are attached to or held on an apparel article that directly or indirectly contacts the skin.
<11> An insect repellent method in which 2-methoxy-4-propylphenol and marjoram oil are sprayed in a certain space such as a room or a car.

Example 1 Evaluation of Suppression of Attracting Behavior to Mosquitoes against Mosquitoes (1) Preparation of Aedes albopictus Aedes aegypti were grown from eggs purchased from Sumika Techno Service Co., Ltd. A plastic pan was filled with water, and filter paper on which eggs were laid was placed. Every day, feed for tropical fish (tetramine baby) was given as food for larvae. About 1 week later, the cocoons were transferred to a mesh cage. As an adult bait, 10% by mass of sucrose was given. After emergence, mating was carried out by raising males and females in the same cage for about one week.

(2) Attraction assay 200 post-mating females and 20 male Aedes albopictus were transferred to plastic cages (30 x 30 x 30 cm). A plastic plate of the same size as the cage wall is prepared, and a breathable sheet for disposable diapers (air permeability (JIS P8117): 2 seconds / 300 mL, 32 sheets or more, moisture permeability (JIS) in a 5x5 cm hole in the center. Z0208): 1 g / 100 cm 2 · 1 hr or more) is attached, and the evaluation sample (2-methoxy-4-propylphenol (SIGMA-ALDRICH)), marjoram oil (steamed distillate; Naturally Vibrant Health) with ethanol to 0.1% by volume And 50 μL each of ethanol alone (control), 2-methoxy-4-propylphenol, marjoram oil, 2-methoxy-4-propylphenol + marjoram oil was added to the breathable sheet and left for 1 minute. To volatilize ethanol and place plastic on the cage wall. A plate was attached, palms were applied from the outside of the breathable sheet, breath was activated to activate the mosquitoes, and the number of attracted to the 5 × 5 cm hole after 1 minute was counted. % Converted to the attraction rate.
(Equation 1)
Attraction rate (%) = 100 × ([number of accretion during sample application] / [number of accretion during ethanol application])
The results are shown in FIG.
Combination use of 2-methoxy-4-propylphenol and marjoram oil showed an excellent repellent effect against Aedes albopictus.

Claims (4)

  An insect repellent containing 2-methoxy-4-propylphenol and marjoram oil as active ingredients.   The insect repellent according to claim 1, wherein the insect is at least one selected from mosquitoes, flies, flyfish and flies.   The insect repellent according to claim 2, wherein the insect is a mosquito.   An insect repellent method wherein 2-methoxy-4-propylphenol and marjoram oil are applied to the skin of a mammal.

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