JP2018020184A - Subject information acquisition device and laser equipment - Google Patents

Abstract

PROBLEM TO BE SOLVED: To suppress generation of stray light in laser equipment that drives a shutter to stabilize a laser beam.SOLUTION: A subject information acquisition device includes: irradiation means for irradiating a subject with a laser beam; limiting means for limiting an output of a laser beam from the irradiation means; control means for controlling irradiation of a laser beam and driving of the limiting means; a probe for receiving an acoustic wave to be generated from a subject to which a laser beam is radiated; and constitution means for generating characteristic information of a subject with the use of an acoustic wave. The control means performs irradiation control for allowing a laser beam not to be radiated during driving of the limiting means.SELECTED DRAWING: Figure 1

Description

  The present invention relates to an object information acquisition apparatus and a laser apparatus.

  As one of optical imaging techniques using light, there is Photo Acoustic Imaging (PAI: photoacoustic imaging). In photoacoustic imaging, a living body that is a subject is irradiated with pulsed light, and acoustic waves generated at a test site such as a tumor due to energy absorption of the pulsed light are received by a probe. Then, by analyzing the received signal output from the probe, the optical characteristic distribution in the living body is acquired as image data.

  Patent Document 1 discloses a device that holds a breast from both sides with a holding member and receives an acoustic wave while a probe scans the holding member two-dimensionally. By scanning the probe two-dimensionally, it is possible to acquire characteristic information at a plurality of positions in the subject.

  In addition, a technique for calculating the abundance ratio of substances having different light absorption spectra using signals from acoustic waves obtained by irradiating light of a plurality of wavelengths from a laser device has been studied. For example, Non-Patent Document 1 describes a method for calculating oxygen saturation in blood by using a plurality of wavelengths, focusing on the difference in light absorption spectrum between oxygenated hemoglobin and reduced hemoglobin present in blood. Has been.

  Patent Document 2 discloses a photoacoustic apparatus in which a shutter that opens and closes and controls the passage of laser light is installed in an optical path of laser light between a laser light source and a living tissue. In this apparatus, the shutter is closed until the laser beam is stabilized, and the shutter is opened at the irradiation timing, so that the laser beam can be irradiated stably.

JP 2010-022812 A JP 2012-173246 A

Journal of Biomedical Optics 14 (5), 054007

In Patent Document 2, a stable laser beam is irradiated by closing the shutter and opening the shutter only when measuring photoacoustic waves until the laser beam is thermally stabilized by providing a shutter.
However, when the laser is irradiated while the shutter is open, there is a possibility that the laser is irradiated where the shutter is not completely opened, and stray light may be generated. When stray light is generated, there is a possibility that a device such as a sensor constituting the apparatus may break down.

  The present invention has been made in view of the above problems, and an object of the present invention is to suppress the generation of stray light in a laser device that drives a shutter to stabilize laser light.

The present invention employs the following configuration. That is,
Irradiating means for irradiating the subject with laser light;
Limiting means for limiting the output of the laser light from the irradiation means;
Control means for controlling irradiation of the laser light and driving of the limiting means;
A probe for receiving an acoustic wave generated from the subject irradiated with the laser beam;
Means for generating characteristic information of the subject using the acoustic wave;
Have
The object information acquisition apparatus according to claim 1, wherein the control unit performs irradiation control in which the laser beam is not irradiated while the limiting unit is driven.

The present invention also employs the following configuration. That is,
Irradiating means for irradiating laser light;
Limiting means for limiting the output of the laser light from the irradiation means;
Control means for controlling irradiation of the laser light and driving of the limiting means;
Have
The control unit is a laser device that performs irradiation control so that the laser beam is not irradiated while the limiting unit is driven.

  ADVANTAGE OF THE INVENTION According to this invention, generation | occurrence | production of a stray light can be suppressed in the laser apparatus which drives a shutter and stabilizes a laser beam.

The block diagram which shows the structure of the subject information acquisition apparatus. The flowchart which shows an example which restrict | limits irradiation at the time of shutter drive. The schematic diagram which shows the structure of a laser apparatus.

  Hereinafter, preferred embodiments of the present invention will be described with reference to the drawings. However, the dimensions, materials, shapes, and relative arrangements of the components described below should be changed as appropriate according to the configuration of the apparatus to which the invention is applied and various conditions. It is not intended to limit the following description.

  In the present invention, the acoustic wave includes an acoustic wave called a sound wave, an ultrasonic wave, a photoacoustic wave, and an optical ultrasonic wave, and the receiver receives the acoustic wave propagated in the subject. That is, the subject information acquisition apparatus of the present invention receives the acoustic wave generated in the subject by irradiating the subject with light (electromagnetic wave), and acquires the characteristic information in the subject. Includes devices that use.

  The characteristic information in the subject acquired at this time is the initial sound pressure of the acoustic wave generated by the light irradiation, or the light energy absorption density derived from the initial sound pressure, the absorption coefficient, and the substance constituting the tissue. The subject information reflecting the concentration and the like is shown. The concentration of the substance is, for example, oxygen saturation or oxy / deoxyhemoglobin concentration. Further, the characteristic information may be acquired not as numerical data but as distribution information of each position in the subject. That is, distribution information such as an absorption coefficient distribution and an oxygen saturation distribution may be acquired as image data.

Hereinafter, the present invention will be described in detail with reference to the drawings. In addition, the same code | symbol is attached | subjected to the same component in principle, and description is abbreviate | omitted. The present invention can also be understood as an operation method and a control method of an object information acquisition apparatus and a laser apparatus. The present invention can also be understood as a program for causing an information processing apparatus or the like to execute a control method.
Although details will be described in each embodiment, the present invention is characterized in that the shutter is not driven during laser irradiation.

<Embodiment>
In the present embodiment, a method of not performing laser irradiation while driving a shutter in an apparatus using the photoacoustic effect will be described.

(Basic equipment configuration)
FIG. 1 is a block diagram showing the configuration of the subject information acquisition apparatus according to this embodiment.
The subject information acquisition apparatus includes a holding member 102 that holds a subject 101 such as a living body, an irradiation unit 103 that emits light, and a probe 104 that is a receiver that receives an acoustic wave and converts it into a received signal. The apparatus further generates image data using an output signal from a measurement unit 105 that amplifies the received signal and converts it into a digital signal, a signal processing unit 106 that performs integration processing of the digitized received signal, and the like. The image construction unit 107 is provided. The apparatus further includes an image display unit 108 that displays an image generated by the image configuration unit 107, a scanning control unit 109 that moves the irradiation unit 103 and the probe 104.
Details of each block will be described below.

(Holding member)
As the subject 101, for example, a living body breast can be considered. The holding member 102 is configured by a pair of a first holding member 102A and a second holding member 102B that hold the subject 101 from both sides. The relative positions of the two holding members are controlled by a holding mechanism (not shown) in order to change the holding gap and the holding pressure. In the following description, when it is not necessary to distinguish the holding members 102A and 102B, they are collectively referred to as the holding member 102.

The subject 101 is fixed by sandwiching the subject 101 between the holding members 102, and measurement errors due to movement of the subject 101 are reduced. Further, the subject 101 can be adjusted to a desired thickness in accordance with the penetration depth of light. Note that since the holding member 102B is located on the optical path of light, a material having high transmittance with respect to light to be used, such as polymethylpentene, is preferable. In addition, the holding member 102A on the probe 104 side is preferably a member having high acoustic matching with the probe 104.
The user opens a door (not shown) provided in the housing and performs a procedure for holding the subject 101, then fixes the holding member 102, closes the door, and starts imaging.

(Irradiation unit)
The irradiation unit 103 that irradiates the subject 101 with light includes a light source that generates light and an irradiation unit that guides and irradiates light from the light source to the subject. The irradiation unit corresponds to the irradiation means of the present invention.
As the light source, a solid laser capable of generating pulsed light having a center wavelength in the near infrared region of 530 to 1300 nm (pulse width of 100 nsec or less) is preferable. For example, a Yttrium-Aluminium-Garnet laser or a Titan-Sapphire laser is used. Note that the emission wavelength is switched between 530 nm and 1300 nm according to a light absorbing substance (for example, hemoglobin, glucose, cholesterol, etc.) in the subject to be measured.

  The light source includes a pulse forming network, a flash lamp, a laser medium, a Q-switch, a wavelength switching unit, a variable voltage power supply, a voltage control unit, a light irradiation restriction unit, a light irradiation limitation driving unit, and a light irradiation limitation control unit.

The voltage control means controls the variable voltage power supply, accumulates charges according to the voltage of the variable voltage power supply by the pulse forming network, and creates a high current pulse from the accumulated charges. Further, a high current pulse from a pulse forming network is sent to a flash lamp to excite the laser medium, thereby emitting laser light.
The Q-switch outputs a giant pulse from the laser medium excited by Q-switching.

The light irradiation limiting means (shutter in this case) is disposed on the emission end side on the optical path in order to prevent laser output from an irradiation unit, which will be described later, and completely blocks light when closed, and light when opened. Is output. The light irradiation limiting means corresponds to the limiting means of the present invention.
The light irradiation limiting unit is controlled by the light irradiation limiting driving unit. The light irradiation restriction control means monitors the light irradiation driving means, and notifies the voltage control means or the Q-switch to suppress the laser output. The light irradiation restriction driving means corresponds to a power source for driving the shutter. The light irradiation restriction control means corresponds to an information processing device or a circuit that gives a drive instruction to the power source. The light irradiation restriction control means corresponds to one function of the control means of the present invention.

  The wavelength used in the wavelength switching means is changed. Unstable laser light generated when changing the wavelength to be used is blocked by the light irradiation limiting means, and only effective laser light is used. For this reason, when changing the wavelength, the light irradiation control means is closed to limit the laser output. The light irradiation limiting means is also used for output control in an unstable state at the start of light irradiation.

Among these components, main parts are shown in FIG. A controller 303 controls the entire apparatus. After the laser medium 301 is irradiated with excitation light from a flash lamp (not shown) to be in an inversion distribution state, the laser is irradiated upon receiving a laser irradiation instruction S1 from the controller 303. The irradiation instruction is performed by Q-switching, for example.
At this time, a desired wavelength is selected by outputting a wavelength change instruction S2 to the wavelength switching means 302. The wavelength can be selected using a known method such as a filter or a prism. Further, when the light irradiation limiting means 304 that is a shutter is closed by the opening / closing instruction S <b> 3, no light is output from the output coupler 305.

  However, if the light irradiation limiting means is a mechanical shutter, a certain time is required for the opening and closing operation. Therefore, if light is irradiated before the shutter opens or closes after receiving the opening / closing instruction, at least part of the light may become stray light. For example, if the irradiation frequency of the pulse laser beam is 20 Hz and the operation of opening the shutter takes 100 ms, the laser is irradiated while the shutter is being opened. Therefore, the control of the present invention is necessary.

A method for limiting the output of the laser by driving the light irradiation limiting means when switching the wavelength of the laser to be used will be described below with reference to the flowchart of FIG.
FIG. 2 starts from switching wavelengths.

  First, in step S201, it is checked whether the light irradiation restriction control means is currently driving the light irradiation restriction means. At this time, as a method for determining whether the light is being driven, there is a method of monitoring whether the light irradiation restriction driving means is driving the light irradiation control means using a sensor or the like. In addition, when the light irradiation restriction driving means periodically drives the light irradiation control means, there is a method in which the light irradiation restriction control means checks the periodic interval.

Next, in step S202, it is determined whether or not the light irradiation limiting means is being driven.
If the determination result is NO (not driving), the process proceeds to step S203, where the voltage control means controls the variable voltage power source and outputs a laser.
On the other hand, if the determination result is YES (during driving), the process proceeds to step S204 to perform control for suppressing the output of the laser. First, the light irradiation restriction control means notifies the voltage control means or the Q-switch to stop the laser output. The voltage control means or Q-switch that has received the notification performs control to suppress the laser output.

Specific control of the voltage control means in S204 includes a method for suppressing the voltage application from the variable voltage power source to the pulse forming network and a method for suppressing the pulse application to the flash lamp. As a control of the Q-switch, a method of prohibiting Q-switching for laser output is conceivable. The light irradiation restriction control means The notification of stopping the output of the laser may be given only by either the voltage control means or the Q-switch, or by a configuration in which both are notified.
In particular, the method of suppressing the voltage drop from the variable voltage power source to the pulse forming network does not excite the laser medium in the first place, and therefore can more reliably limit the laser output.

Also, instead of performing control such that the laser output is not performed at all as described above, for example, the stray light is weakened by reducing the laser output by reducing the voltage drop from the variable voltage power source to the pulse forming network. It does not matter even if the control is performed.
In the present embodiment, an example is described in which control is performed to limit laser emission during the opening / closing operation of the light irradiation control unit at the time of wavelength switching. Control for limiting the laser emission may be performed.

  The irradiation frequency is usually determined for the light source. This is determined as a design value in order to continuously irradiate pulse light having a desired intensity. Since this irradiation frequency affects the number of photoacoustic measurements that can be performed per unit time, the higher the irradiation frequency, the better.

  Examples of the irradiating unit include a mirror that reflects light, a lens that collects and enlarges light, and changes its shape, a prism that disperses, refracts, and reflects light, an optical fiber that propagates light, and a diffuser plate Can be mentioned. Any irradiation unit may be used as long as light emitted from the light source is irradiated in a desired shape onto a desired region of the subject.

(Probe)
The probe 104 includes an element that receives an acoustic wave and converts it into an electrical signal (received signal). As the element of the probe 104, a conversion element using a piezoelectric phenomenon, a conversion element using optical resonance, a conversion element using a change in capacitance, and the like can be considered. Any element that can receive an acoustic wave and convert it into an electrical signal may be used. Use of a probe in which a plurality of elements are arranged one-dimensionally or two-dimensionally is preferable in terms of increasing the measurement area, shortening the measurement time, improving the SN ratio, and the like.

  Since the sound pressure of the generated acoustic wave is proportional to the light intensity, it is preferable to irradiate the area in front of the probe in order to improve the SN ratio of the received signal. Therefore, it is preferable to arrange the light emitting end of the irradiation unit 103 and the probe 104 at a position facing each other with the subject interposed therebetween. It is preferable that the scanning control unit 109 scans the light emitting end and the probe 104 in synchronization so as to maintain the positional relationship between them. In addition, since the irradiation unit guides light to the probe 104 side, the object 101 can be irradiated with light from the same side as the probe 104.

(Measurement part)
The measurement unit 105 includes a signal amplification unit that amplifies an analog signal (analog reception signal) input from the probe 104 and an A / D conversion unit that converts the analog signal into a digital signal. In the signal amplification unit, in order to obtain image data having a uniform contrast regardless of the depth in the subject, the amplification gain is increased according to the time from the irradiation of the light until the acoustic wave reaches the element of the probe. Perform control to increase or decrease.

(Signal processing part)
The signal processing unit 106 corrects element sensitivity variation for the digital received signal output from the measuring unit 105, complements a physically or electrically missing element, recording operation on a recording medium (not shown), noise Perform integration processing for reduction. The integration process is performed in order to reduce the system noise and improve the S / N ratio of the received signal by repeatedly receiving the acoustic wave with respect to the subject 101 at the same scanning position and performing the averaging process of the received signal. .

(Image composition part)
The image construction unit 107 uses the signal output from the signal processing unit 106 to generate a distribution (characteristic distribution such as an absorption coefficient distribution or an oxygen saturation distribution) indicating optical characteristic information at each position in the subject 101. Acquired as image data. Further, image data that is more suitable for diagnosis may be acquired by applying various correction processes such as brightness adjustment, distortion correction, and extraction of a region of interest to the generated image data. The image construction unit corresponds to the construction means of the present invention. The constituent means of the present invention may further include the functions of the measurement unit and the signal processing unit.

(Image display part)
The image display unit 108 receives the image data from the image configuration unit 107 and displays an image of the characteristic distribution.

(Scanning control unit)
As described above, the scanning control unit 109 controls the light emission end and the scanning position of the probe 104. By performing two-dimensional scanning on the subject 101 and receiving acoustic waves at each scanning position, a wide range of characteristic information can be acquired even with a small probe.
In the present embodiment, the irradiation member 103 and the probe 104 are scanned on the holding member 102 to receive acoustic waves. However, the probe is manually scanned using a plurality of wavelengths, and photoacoustics are obtained. The present embodiment can also be applied to an apparatus that performs measurement.
When applied to an apparatus that manually scans the probe and performs photoacoustic measurement, it is possible to prevent the subject from being irradiated with unnecessary irradiation light that is not used for measurement due to wavelength switching. Especially when the subject is a living body, it is necessary to suppress unnecessary light irradiation.

  103: Irradiation unit, 104: Probe, 107: Image construction unit, 301: Laser medium, 302: Wavelength switching means, 303: Control controller, 304: Light irradiation limiting means

Claims (8)

Irradiating means for irradiating the subject with laser light;
Limiting means for limiting the output of the laser light from the irradiation means;
Control means for controlling irradiation of the laser light and driving of the limiting means;
A probe for receiving an acoustic wave generated from the subject irradiated with the laser beam;
Means for generating characteristic information of the subject using the acoustic wave;
Have
The object information acquiring apparatus according to claim 1, wherein the control unit performs irradiation control in which the laser beam is not irradiated while the limiting unit is driven. The limiting means is a shutter disposed on the optical path of the laser light,
The object information acquiring apparatus according to claim 1, wherein the control unit performs the irradiation control when the shutter is opened and closed. The irradiation means irradiates a laser beam having a wavelength selected from a plurality of wavelengths,
The object information acquiring apparatus according to claim 1, wherein the control unit performs the irradiation control when changing the wavelength of the laser beam. The irradiating means irradiates a laser beam by a flash lamp receiving a pulse created by a pulse forming network exciting a laser medium and a Q-switch Q-switching the laser medium. The subject information acquisition apparatus according to any one of claims 1 to 3. The object information acquiring apparatus according to claim 4, wherein the control unit performs the irradiation control by suppressing application of a voltage to the pulse forming network. The object information acquiring apparatus according to claim 4, wherein the control unit performs the irradiation control by suppressing a drop of a pulse to the flash lamp. The object information acquiring apparatus according to claim 4, wherein the control unit performs the irradiation control by prohibiting Q-switching with respect to the Q-switch. Irradiating means for irradiating laser light;
Limiting means for limiting the output of the laser light from the irradiation means;
Control means for controlling irradiation of the laser light and driving of the limiting means;
Have
The laser device according to claim 1, wherein the control unit performs irradiation control such that the laser beam is not irradiated while the limiting unit is driven.

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