JP2017537057A5 - - Google Patents
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- JP2017537057A5 JP2017537057A5 JP2017516161A JP2017516161A JP2017537057A5 JP 2017537057 A5 JP2017537057 A5 JP 2017537057A5 JP 2017516161 A JP2017516161 A JP 2017516161A JP 2017516161 A JP2017516161 A JP 2017516161A JP 2017537057 A5 JP2017537057 A5 JP 2017537057A5
- Authority
- JP
- Japan
- Prior art keywords
- pharmaceutical composition
- subject
- stem cells
- placental stem
- composition according
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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- 210000004991 placental stem cell Anatomy 0.000 claims description 13
- 239000000203 mixture Substances 0.000 claims description 11
- 210000002358 circulating endothelial cell Anatomy 0.000 claims description 7
- 102000003729 Neprilysin Human genes 0.000 claims description 5
- 108090000028 Neprilysin Proteins 0.000 claims description 5
- 239000008194 pharmaceutical composition Substances 0.000 claims 20
- 208000008960 Diabetic foot Diseases 0.000 claims 6
- 210000002683 foot Anatomy 0.000 claims 4
- 102100031573 Hematopoietic progenitor cell antigen CD34 Human genes 0.000 claims 3
- 101000777663 Homo sapiens Hematopoietic progenitor cell antigen CD34 Proteins 0.000 claims 3
- 230000036772 blood pressure Effects 0.000 claims 2
- 208000024891 symptom Diseases 0.000 claims 2
- 208000034819 Mobility Limitation Diseases 0.000 claims 1
- 208000025865 Ulcer Diseases 0.000 claims 1
- 206010052428 Wound Diseases 0.000 claims 1
- 208000027418 Wounds and injury Diseases 0.000 claims 1
- 238000002266 amputation Methods 0.000 claims 1
- 210000003423 ankle Anatomy 0.000 claims 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims 1
- 238000002845 discoloration Methods 0.000 claims 1
- 208000015181 infectious disease Diseases 0.000 claims 1
- 238000007918 intramuscular administration Methods 0.000 claims 1
- 229910052760 oxygen Inorganic materials 0.000 claims 1
- 239000001301 oxygen Substances 0.000 claims 1
- 208000030613 peripheral artery disease Diseases 0.000 claims 1
- 230000000284 resting effect Effects 0.000 claims 1
- 231100000397 ulcer Toxicity 0.000 claims 1
- 210000004027 cell Anatomy 0.000 description 29
- 230000003169 placental effect Effects 0.000 description 18
- 230000001464 adherent effect Effects 0.000 description 8
- 210000000130 stem cell Anatomy 0.000 description 7
- 238000000034 method Methods 0.000 description 6
- 210000002826 placenta Anatomy 0.000 description 5
- 102000004142 Trypsin Human genes 0.000 description 4
- 108090000631 Trypsin Proteins 0.000 description 4
- 210000001185 bone marrow Anatomy 0.000 description 4
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 4
- 239000012588 trypsin Substances 0.000 description 4
- 239000001506 calcium phosphate Substances 0.000 description 3
- 210000003958 hematopoietic stem cell Anatomy 0.000 description 3
- 210000002901 mesenchymal stem cell Anatomy 0.000 description 3
- 210000005059 placental tissue Anatomy 0.000 description 3
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 description 2
- 210000001691 amnion Anatomy 0.000 description 2
- OSGAYBCDTDRGGQ-UHFFFAOYSA-L calcium sulfate Chemical compound [Ca+2].[O-]S([O-])(=O)=O OSGAYBCDTDRGGQ-UHFFFAOYSA-L 0.000 description 2
- 229910010293 ceramic material Inorganic materials 0.000 description 2
- 210000001136 chorion Anatomy 0.000 description 2
- 210000004700 fetal blood Anatomy 0.000 description 2
- 230000008774 maternal effect Effects 0.000 description 2
- 238000006386 neutralization reaction Methods 0.000 description 2
- 229920000371 poly(diallyldimethylammonium chloride) polymer Polymers 0.000 description 2
- 210000001988 somatic stem cell Anatomy 0.000 description 2
- 210000002536 stromal cell Anatomy 0.000 description 2
- 239000006228 supernatant Substances 0.000 description 2
- 210000001519 tissue Anatomy 0.000 description 2
- 235000008733 Citrus aurantifolia Nutrition 0.000 description 1
- 108010035532 Collagen Proteins 0.000 description 1
- 102000008186 Collagen Human genes 0.000 description 1
- 235000019739 Dicalciumphosphate Nutrition 0.000 description 1
- KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 description 1
- 102000016359 Fibronectins Human genes 0.000 description 1
- 108010067306 Fibronectins Proteins 0.000 description 1
- 108010011593 Healos Proteins 0.000 description 1
- 101000599852 Homo sapiens Intercellular adhesion molecule 1 Proteins 0.000 description 1
- 102100037877 Intercellular adhesion molecule 1 Human genes 0.000 description 1
- 102000043129 MHC class I family Human genes 0.000 description 1
- 108091054437 MHC class I family Proteins 0.000 description 1
- 240000006909 Tilia x europaea Species 0.000 description 1
- 235000011941 Tilia x europaea Nutrition 0.000 description 1
- GLNADSQYFUSGOU-GPTZEZBUSA-J Trypan blue Chemical compound [Na+].[Na+].[Na+].[Na+].C1=C(S([O-])(=O)=O)C=C2C=C(S([O-])(=O)=O)C(/N=N/C3=CC=C(C=C3C)C=3C=C(C(=CC=3)\N=N\C=3C(=CC4=CC(=CC(N)=C4C=3O)S([O-])(=O)=O)S([O-])(=O)=O)C)=C(O)C2=C1N GLNADSQYFUSGOU-GPTZEZBUSA-J 0.000 description 1
- 239000000853 adhesive Substances 0.000 description 1
- 230000001070 adhesive effect Effects 0.000 description 1
- 238000003556 assay Methods 0.000 description 1
- 102000015736 beta 2-Microglobulin Human genes 0.000 description 1
- 108010081355 beta 2-Microglobulin Proteins 0.000 description 1
- 239000012620 biological material Substances 0.000 description 1
- 239000000090 biomarker Substances 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000000601 blood cell Anatomy 0.000 description 1
- 210000000988 bone and bone Anatomy 0.000 description 1
- YYRMJZQKEFZXMX-UHFFFAOYSA-L calcium bis(dihydrogenphosphate) Chemical compound [Ca+2].OP(O)([O-])=O.OP(O)([O-])=O YYRMJZQKEFZXMX-UHFFFAOYSA-L 0.000 description 1
- 229910000019 calcium carbonate Inorganic materials 0.000 description 1
- WUKWITHWXAAZEY-UHFFFAOYSA-L calcium difluoride Chemical compound [F-].[F-].[Ca+2] WUKWITHWXAAZEY-UHFFFAOYSA-L 0.000 description 1
- 229910001634 calcium fluoride Inorganic materials 0.000 description 1
- FUFJGUQYACFECW-UHFFFAOYSA-L calcium hydrogenphosphate Chemical compound [Ca+2].OP([O-])([O-])=O FUFJGUQYACFECW-UHFFFAOYSA-L 0.000 description 1
- BRPQOXSCLDDYGP-UHFFFAOYSA-N calcium oxide Chemical compound [O-2].[Ca+2] BRPQOXSCLDDYGP-UHFFFAOYSA-N 0.000 description 1
- 239000000292 calcium oxide Substances 0.000 description 1
- ODINCKMPIJJUCX-UHFFFAOYSA-N calcium oxide Inorganic materials [Ca]=O ODINCKMPIJJUCX-UHFFFAOYSA-N 0.000 description 1
- KMQAPZBMEMMKSS-UHFFFAOYSA-K calcium;magnesium;phosphate Chemical compound [Mg+2].[Ca+2].[O-]P([O-])([O-])=O KMQAPZBMEMMKSS-UHFFFAOYSA-K 0.000 description 1
- 230000000747 cardiac effect Effects 0.000 description 1
- 230000010261 cell growth Effects 0.000 description 1
- 239000002771 cell marker Substances 0.000 description 1
- 229920001436 collagen Polymers 0.000 description 1
- 239000002131 composite material Substances 0.000 description 1
- 229910000390 dicalcium phosphate Inorganic materials 0.000 description 1
- 229940038472 dicalcium phosphate Drugs 0.000 description 1
- 230000029087 digestion Effects 0.000 description 1
- 210000001671 embryonic stem cell Anatomy 0.000 description 1
- 210000002257 embryonic structure Anatomy 0.000 description 1
- 230000003511 endothelial effect Effects 0.000 description 1
- 230000006862 enzymatic digestion Effects 0.000 description 1
- 230000007717 exclusion Effects 0.000 description 1
- 229910052587 fluorapatite Inorganic materials 0.000 description 1
- 239000011521 glass Substances 0.000 description 1
- 239000001963 growth medium Substances 0.000 description 1
- 230000035876 healing Effects 0.000 description 1
- 229910052588 hydroxylapatite Inorganic materials 0.000 description 1
- 238000011534 incubation Methods 0.000 description 1
- 238000002955 isolation Methods 0.000 description 1
- 239000004571 lime Substances 0.000 description 1
- 210000004185 liver Anatomy 0.000 description 1
- 229910000150 monocalcium phosphate Inorganic materials 0.000 description 1
- 235000019691 monocalcium phosphate Nutrition 0.000 description 1
- 210000002894 multi-fate stem cell Anatomy 0.000 description 1
- 210000001665 muscle stem cell Anatomy 0.000 description 1
- 210000001178 neural stem cell Anatomy 0.000 description 1
- 210000000056 organ Anatomy 0.000 description 1
- XYJRXVWERLGGKC-UHFFFAOYSA-D pentacalcium;hydroxide;triphosphate Chemical compound [OH-].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O XYJRXVWERLGGKC-UHFFFAOYSA-D 0.000 description 1
- 230000010412 perfusion Effects 0.000 description 1
- 210000005259 peripheral blood Anatomy 0.000 description 1
- 239000011886 peripheral blood Substances 0.000 description 1
- 239000000047 product Substances 0.000 description 1
- 238000011084 recovery Methods 0.000 description 1
- 238000003757 reverse transcription PCR Methods 0.000 description 1
- 229920002994 synthetic fiber Polymers 0.000 description 1
- GBNXLQPMFAUCOI-UHFFFAOYSA-H tetracalcium;oxygen(2-);diphosphate Chemical compound [O-2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O GBNXLQPMFAUCOI-UHFFFAOYSA-H 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 229910000391 tricalcium phosphate Inorganic materials 0.000 description 1
- 235000019731 tricalcium phosphate Nutrition 0.000 description 1
- 229940078499 tricalcium phosphate Drugs 0.000 description 1
- 210000003954 umbilical cord Anatomy 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
Applications Claiming Priority (11)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462056008P | 2014-09-26 | 2014-09-26 | |
| US62/056,008 | 2014-09-26 | ||
| US201562145551P | 2015-04-10 | 2015-04-10 | |
| US62/145,551 | 2015-04-10 | ||
| US201562151726P | 2015-04-23 | 2015-04-23 | |
| US62/151,726 | 2015-04-23 | ||
| US201562170757P | 2015-06-04 | 2015-06-04 | |
| US62/170,757 | 2015-06-04 | ||
| US201562220620P | 2015-09-18 | 2015-09-18 | |
| US62/220,620 | 2015-09-18 | ||
| PCT/US2015/052276 WO2016049485A1 (en) | 2014-09-26 | 2015-09-25 | Treatment of diabetic foot ulcer using placental stem cells |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020143608A Division JP2021001178A (ja) | 2014-09-26 | 2020-08-27 | 胎盤幹細胞を使用する糖尿病性足部潰瘍の治療 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2017537057A JP2017537057A (ja) | 2017-12-14 |
| JP2017537057A5 true JP2017537057A5 (https=) | 2018-11-15 |
Family
ID=55582072
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017516161A Pending JP2017537057A (ja) | 2014-09-26 | 2015-09-25 | 胎盤幹細胞を使用する糖尿病性足部潰瘍の治療 |
| JP2020143608A Withdrawn JP2021001178A (ja) | 2014-09-26 | 2020-08-27 | 胎盤幹細胞を使用する糖尿病性足部潰瘍の治療 |
| JP2022143365A Pending JP2022184911A (ja) | 2014-09-26 | 2022-09-09 | 胎盤幹細胞を使用する糖尿病性足部潰瘍の治療 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020143608A Withdrawn JP2021001178A (ja) | 2014-09-26 | 2020-08-27 | 胎盤幹細胞を使用する糖尿病性足部潰瘍の治療 |
| JP2022143365A Pending JP2022184911A (ja) | 2014-09-26 | 2022-09-09 | 胎盤幹細胞を使用する糖尿病性足部潰瘍の治療 |
Country Status (4)
| Country | Link |
|---|---|
| US (1) | US20170290861A1 (https=) |
| EP (1) | EP3197467A4 (https=) |
| JP (3) | JP2017537057A (https=) |
| WO (1) | WO2016049485A1 (https=) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113116933A (zh) * | 2021-04-26 | 2021-07-16 | 河北医科大学第四医院 | 一种防治糖尿病足的干细胞组合物及其应用 |
| CN114404590A (zh) * | 2022-01-24 | 2022-04-29 | 四川大学华西医院 | TGF-β抑制剂在制备治疗糖尿病足的药物中的用途 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101622007A (zh) * | 2006-10-06 | 2010-01-06 | 人类起源公司 | 天然(端肽)胎盘胶原组合物 |
| DK2556145T3 (en) * | 2010-04-07 | 2016-11-07 | Anthrogenesis Corp | Angiogenesis using placental stem cells |
| US20120171161A1 (en) * | 2010-12-30 | 2012-07-05 | Sascha Abramson | Compositions comprising placental stem cells and platelet rich plasma, and methods of use thereof |
-
2015
- 2015-09-25 US US15/509,710 patent/US20170290861A1/en not_active Abandoned
- 2015-09-25 EP EP15844825.8A patent/EP3197467A4/en not_active Withdrawn
- 2015-09-25 JP JP2017516161A patent/JP2017537057A/ja active Pending
- 2015-09-25 WO PCT/US2015/052276 patent/WO2016049485A1/en not_active Ceased
-
2020
- 2020-08-27 JP JP2020143608A patent/JP2021001178A/ja not_active Withdrawn
-
2022
- 2022-09-09 JP JP2022143365A patent/JP2022184911A/ja active Pending
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| JP2017537057A5 (https=) | ||
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