JP2017536360A - Foamable alcohol-based disinfecting composition comprising branched polyethoxylated dimethicone foamable surfactant and isopropanol - Google Patents

Abstract

An alcohol-based composition is provided that contains a large amount of ethanol and also produces good foam when a branched polyethoxylated dimethicone foaming surfactant is used. The present invention relates to a foamable alcohol system comprising a foamable surfactant selected from branched PEG-8 to PEG-12 dimethicone surfactants and combinations thereof, ethanol, and a selected amount of isopropanol. A composition is provided. [Selection] Figure 1

Description

  One or more aspects of the present invention relate to foamable alcoholic compositions, and more particularly to foamable alcoholic compositions comprising ethanol, a branched polyethoxylated dimethicone surfactant and a selected amount of isopropanol. .

  Foam cleaning products are popular and one reason is that they tend to spread on the surface. Consumers seem to prefer the comfort of whipped soap products. Foams are required to provide the same detergency as liquids or gels in smaller amounts, at least in part due to the larger surface area of the foam. Due to the higher surface tension of the foam, a properly formulated foam product will not drip or scatter like conventional gel or liquid products. This prevents damage to the floor and walls of the facility where the product dispenser is used. Production of foam products is easier than gel products, which often contain cumbersome powdery thickeners.

  Polyethoxylated (PEG) dimethicone surfactants have been used as foaming agents for alcoholic foams. U.S. Patent No. 7,842,725 describes foaming alcohol compositions comprising selected dimethicone surfactants, the PEG-8 to PEG-12 linear dimethicone surfactants being the same It is described as being more effective in foaming than dimethicone surfactants having different polymer structures with different PEG chain lengths.

  More specifically, U.S. Pat. No. 7,842,725 describes linear block copolymers of PEG with polydimethylsiloxane (specifically, PEG-8 dimethicone, PEG-10 dimethicone, PEG- Copolymers with the same INCI name but different polymer structures, although the INCI name of 12 dimethicone) can provide sufficient foam height for use as the primary foaming component of a non-aerosol foamable alcohol composition Is described as not possible. In fact, US Pat. No. 7,842,725 states that polymers with pendant PEG groups or other hyperbranched polymer structures do not produce enough foam to be used as the primary foaming surfactant. Have been described.

As described in U.S. Pat. No. 7,842,725 and generally known in the art, linear PEG dimethicone copolymers have polyethylene glycol chain units at the ends of the linear polydimethylsiloxane backbone. Is considered to be a linear block copolymer bonded. Linear PEG dimethicone copolymers can generally be represented by the following structure:
(Wherein R is CH ₃ or CH ₂ CH ₃ ). In U.S. Pat. No. 7,842,725, m is 4 to 20 on average, y is 1 to 5 on average, and n is 8 to 12 on average.

On the other hand, the pendant PEG dimethicone copolymer is considered to be a linear polydimethylsiloxane polymer having PEG groups bonded to the polydimethylsiloxane main chain. The PEG group may be bonded to the end of the end chain of polydimethylsiloxane or may not be bonded. Thus, in the above structure, one or more R groups are replaced with PEG groups. Such pendant copolymers are often referred to as branched or comb polymers. US Pat. No. 7,842,725 describes that these copolymers can generally be represented by the following structure:
(Wherein R is independently CH ₃ , CH ₂ CH ₃ , or an ethoxylated _{alkyl chain} (eg, CH ₂ CH ₂ CH ₂ O (CH ₂ CH ₂ O) _n H) directly attached to the silicone end group) Where a is the number of repeating silicone groups). As described above, one or more of the terminal methyl groups may be replaced with a PEG group, but in that case the copolymer is also considered to be a branched copolymer.

  Depending on the application, a high level of foam quality may be required and the use of linear PEG dimethicone surfactants may be limited. Accordingly, there is a need in the art for an improved foamable alcohol-based composition that can be foamed using a branched PEG dimethicone surfactant.

  Isopropyl alcohol is listed as an antifoaming agent by the Personal Care Products Council.

  The present invention includes a foaming surfactant comprising a foaming surfactant selected from the group consisting of branched PEG-8 to PEG-12 dimethicone surfactants and combinations thereof and a selected combination of ethanol and isopropanol. An alcohol-based composition is provided.

  The present invention further provides a non-aerosol foamable alcoholic composition comprising at least about 60% ethanol by weight based on the total weight of the alcoholic composition, a branched PEG-8 to PEG-12 dimethicone surfactant, and A foamable alcoholic composition is provided comprising a foamable surfactant selected from the group consisting of combinations thereof and at least about 3% by weight of isopropanol based on the total weight of the alcoholic composition.

  The present invention is further a method of forming a stable non-aerosol alcoholic foam, comprising at least about 60 wt% ethanol and about 0.75 to about 10 wt% branched PEG-8 to PEG-12 dimethicone surfactant. Combining a foaming surfactant selected from the group consisting of agents and combinations thereof with at least about 3 to about 15% by weight of isopropanol to form a foamable alcohol-based composition (all proportions described above). Removing the alcohol-based composition by using a non-aerosol foaming pump to form a foam, wherein the foam is an alcohol-based composition based on the total weight of the alcohol-based composition; Providing a method having improved stability compared to foams formed from equivalent compositions comprising 0 to 3 wt% isopropanol based on total weight That.

  The present invention further provides a method of forming a non-aerosol alcoholic foam comprising at least about 60% by weight ethanol and from about 0.75 to about 10% by weight branched PEG-8 to PEG-12 dimethicone surfactant and Combining a foamable surfactant selected from the group consisting of those with at least about 3 to about 15% by weight of isopropanol to form a foamable alcoholic composition (all proportions of said alcoholic system). Removing the alcohol-based composition using a non-aerosol foaming pump to form a foam, wherein the foam is the total weight of the alcohol-based composition A method is provided that has improved quality compared to foams formed from equivalent compositions comprising 0 to 3 wt% isopropanol on a basis.

  The present invention is further a method of forming a stable non-aerosol alcoholic foam, comprising at least about 60 wt% ethanol and about 0.75 to about 10 wt% branched PEG-8 to PEG-12 dimethicone surfactant. Combining a foaming surfactant selected from the group consisting of agents and combinations thereof with at least about 3 to about 15% by weight of isopropanol to form a foamable alcohol-based composition (all proportions described above). Removing the alcoholic composition using a non-aerosol foaming pump to form a foam, wherein the foam comprises the same amount of ethanol and Foam formed from a composition comprising isopropanol but wherein the branched surfactant is replaced with a linear polyethoxylated dimethicone surfactant Having improved stability base, provides a method.

  The present invention further provides a method of forming a non-aerosol alcoholic foam comprising at least about 60% by weight ethanol and from about 0.75 to about 10% by weight branched PEG-8 to PEG-12 dimethicone surfactant and Combining a foamable surfactant selected from the group consisting of those with at least about 3 to about 15% by weight of isopropanol to form a foamable alcoholic composition (all proportions of said alcoholic system). Removing the alcohol-based composition using a non-aerosol foaming pump to form a foam, wherein the foam comprises the same amount of ethanol and isopropanol. Compared to foam formed from a composition comprising, but wherein said branched surfactant is replaced by a linear polyethoxylated dimethicone surfactant Having good and quality, to provide a method.

    FIG. 1 is a graphical representation of the measured foam stability of an alcohol-based composition containing a branched PEG-10 dimethicone foaming surfactant and 0-10 wt% isopropanol.

    FIG. 2 is a graphical representation of foam stability measurements of an alcohol-based composition containing linear PEG-10 dimethicone foaming surfactant and 0-10 wt% isopropanol.

  One or more aspects of the present invention relate to foamable alcohol-based compositions, and more particularly, greater than 60% by weight ethanol and a foamable surfactant selected from branched polyethoxylated dimethicone surfactants. A foamable alcohol-based composition comprising a selected amount of isopropanol.

  It means that the composition according to the invention is alcoholic, i.e. it must contain at least 40% by weight of alcohol. In one or more embodiments, the majority of the alcohol is ethanol.

  Generally, the amount of ethanol contained in the alcoholic composition of the present invention is at least about 40% by weight based on the total weight of the alcoholic composition. In one or more embodiments, the alcohol-based composition comprises at least about 45 wt% ethanol, in another embodiment, the alcohol-based composition comprises at least about 50 wt% ethanol, and in yet another embodiment, The alcoholic composition comprises at least about 60% ethanol by weight (% by weight is based on the total weight of the alcoholic composition). In one or more embodiments, the alcohol-based composition comprises at least about 65 wt% ethanol, and in yet another embodiment, the alcohol-based composition comprises at least about 70 wt% ethanol, and in yet another embodiment The alcohol-based composition comprises at least about 75% ethanol by weight (% by weight is based on the total weight of the alcohol-based composition). In certain cases, a greater or lesser amount of ethanol may be required, depending, inter alia, on the other ingredients and / or amounts used in the composition. In certain embodiments, the alcohol-based composition comprises from about 40 wt% to about 98 wt% ethanol, and in other embodiments, the alcohol-based composition comprises from about 45 wt% to about 95 wt% ethanol; In yet another aspect, the alcohol-based composition comprises about 50% to about 90% by weight ethanol, and in yet another aspect, the alcohol-based composition is about 60% to about 85% by weight ethanol. (% By weight is based on the total weight of the alcohol-based composition).

  In one or more embodiments, the ethanol is SDA-3C (a commercial denatured alcohol containing a small amount of isopropanol as a modifying agent). For purposes of this specification, unless otherwise stated, the amount of ethanol is based on the actual amount of ethanol and does not include denaturing agents.

  The foamable surfactant is a surfactant that contributes to the foamability of the alcohol-based composition. In one or more embodiments, the foamable surfactant comprises a branched polyethoxylated dimethicone surfactant. In one or more embodiments, the foamable surfactant comprises a branched PEG-8 to PEG-12 dimethicone surfactant or a combination thereof. In one or more embodiments, the branched foaming surfactant is selected from the group consisting of PEG-8 dimethicone, PEG-10 dimethicone, PEG-12 dimethicone, and mixtures thereof.

  Most of the foamable surfactant may have a branched or linear structure. The branched structure includes a polymer having a main chain and one or more pendant groups bonded to the main chain. The branch structure may be called a pendant structure. In one or more embodiments, the branched foamable surfactant comprises a silicone backbone having one or more polyether group pendants. The branched foamable surfactant may or may not have a polyether group at one or both ends.

  Of course, some amount of linear molecules may be present in surfactants that are mostly branched. In one or more embodiments, up to about 20 wt% of the surfactant molecules may have a linear structure, and in other embodiments, up to about 1 wt% of the surfactant molecules have a linear structure. In other embodiments, up to about 0.5% by weight of the surfactant molecules may have a linear structure, and in other embodiments, up to about 0.5% by weight of the interface. The activator molecules may have a linear structure (% by weight based on the total weight of the foaming surfactant). Accordingly, none of this specification should be construed to indicate that the branched PEG-8 to PEG-12 dimethicone surfactant does not contain a linear structure.

In one aspect, the branched PEG-8 to PEG-12 dimethicone surfactant comprises a compound represented by the following formula:
^{_{R 2 -Si (CH 3) 2}} - [O-Si (CH 3) 2] a - [O-Si (CH 3) R 3] b -O-Si (CH 3) 2 -R 2
Wherein R ² and R ³ independently comprise a methyl group or a group represented by the following formula:
_{- (CH 2) 3 -O- (} CH 2 CH 2 O) c - [CH 2 CH (CH 3) O] d - (CH 2 CH 2 O) e H
(However, at least one R ³ is not CH ₃ , a is an integer of about 3 to about 21, b is an integer of about 1 to about 7, c is an integer of about 0 to about 40, and d is about 0 to about An integer of about 40, e is an integer of about 0 to about 40, where a ≧ 3 × b and c + d + e ≧ 5)).

Examples of commercially available branched PEG-8 to PEG-12 dimethicone surfactants include the following.

  In some embodiments, impurities in the foamable surfactant can adversely affect foam quality and / or stability. Thus, in one or more embodiments, the amount of volatile organic compounds (VOC) in the foamable surfactant is advantageously limited. For the purposes of this specification, VOC includes compounds having a relatively high vapor pressure at normal room temperature conditions. In one or more embodiments, VOC includes any organic compound having a boiling point less than 250 ° C. as measured at standard atmospheric pressure. In one or more embodiments, the VOC includes any organic compound having a boiling point in the range of about 50 ° C. to 260 ° C. (corresponding to a saturated vapor pressure at 25 ° C. of greater than about 100 kPa). In one or more embodiments, at least the VOC includes a by-product of a synthetic reaction to obtain a foamable surfactant. In one or more embodiments, some or all of the VOC is a degradation product of the foamable surfactant.

  In one or more embodiments, the VOC includes cyclomethicone. Examples of VOCs include hexamethylcyclotrisiloxane (D3), octamethylcyclotetrasiloxane (D4), decamethylcyclopentasiloxane (D5), and dodecamethylcyclohexasiloxane (D6).

  In one or more embodiments, the amount of VOC can be determined by methods known in the art such as gravimetric measurement. VOC identification and quantification can also be performed by methods known in the art such as gas chromatography (GC).

  In one or more embodiments, the foamable surfactant comprises from 0 to about 1 weight percent total VOC, based on the total weight of the foamable surfactant. In one aspect, the foamable surfactant comprises less than 0.8% by weight, in other aspects less than 0.6% by weight, and in other aspects less than 0.4% by weight VOC Based on the total weight of the surfactant). In one or more embodiments, the foamable surfactant comprises from 0 to about 0.3 weight percent total VOC, based on the total weight of the foamable surfactant. In other embodiments, the foamable surfactant does not include VOC.

  Foaming surfactants with limited amounts of VOC impurities are further described in International Patent Application Publication (PCT) 2015/061552, which is hereby incorporated by reference.

  The amount of foaming surfactant is not particularly limited as long as an amount effective to provide foaming is present. In certain embodiments, the amount effective to cause foaming may vary depending on the amount of alcohol and other ingredients. In one or more embodiments, the foamable surfactant is at least about 0.25 wt%, in other embodiments at least about 0.5 wt%, in other embodiments at least about 0.75 wt%, in other embodiments It is present in an amount of at least about 1% by weight, and in other embodiments at least about 1.25% by weight (wt% is based on the total weight of the alcoholic composition).

  In one or more embodiments, the amount of foaming surfactant is from about 0.75 to about 15% by weight based on the total weight of the alcoholic composition. In other embodiments, the foamable surfactant is present in an amount of from about 1 to about 10 wt%, in other embodiments from about 1.25 to about 8 wt%, and in other embodiments from about 2 to about 5 wt%. (% By weight is based on the total weight of the alcohol-based composition). It is envisioned that larger amounts may be effective in forming foam. All such weights associated with the listed ingredients are based on activity levels and therefore do not include carriers or by-products that may be included in commercially available materials, unless otherwise specified.

  In one or more embodiments, the foamable surfactant is added directly to the alcohol-based composition. In other embodiments, the foaming surfactant is added to the alcoholic composition as a solution or emulsion. That is, even if the carrier does not adversely affect the foamability of the alcohol-based composition, the foamable surfactant may be premixed with the carrier to form a foamable surfactant solution or emulsion. Good. Examples of carriers include water, alcohols, glycols (such as propylene glycol or ethylene glycol), ketones, linear and / or cyclic hydrocarbons, triglycerides, carbonates, silicones, alkenes, esters ( Acetate, benzoate, fatty acid ester, glyceryl ester, etc.), ethers, amides, polyethylene glycols, and PEG / PPG copolymers, inorganic salt solutions (eg, physiological saline), and mixtures thereof. . Of course, when the foamable surfactant is mixed in advance to form a foamable surfactant solution or emulsion, the alcohol-based composition is adjusted so that the amount of the foamable surfactant is within the above range. The amount of solution or emulsion added to can be selected.

  The foamable surfactant contributes to the foamability of the alcohol-based composition. Importantly, these polyethoxylated dimethicone surfactants, when used as supplied by the supplier, can vary greatly from lot to lot in forming good quality alcoholic foam. Traditionally, it is believed that branched polyethoxylated dimethicone surfactants cannot be used to form good quality alcoholic foams.

  However, it has been found that good quality foams can be formed using branched polyethoxylated dimethicone surfactants in the presence of isopropanol. Conveniently, branched polyethoxylated dimethicone surfactants can be used to increase the total amount of antimicrobial alcohol by adding isopropanol without sacrificing foam quality or stability. Isopropanol is sometimes referred to as 2-propanol, isopropyl alcohol, or IPA.

  In one or more embodiments, isopropanol can be included in the foamable alcohol-based composition without reducing ethanol to maintain foam stability. That is, the total amount of antibacterial alcohol can be increased by adding isopropanol to the foamable alcohol-based composition in addition to ethanol. Addition of isopropanol is advantageous because it does not reduce foam stability.

  In one or more embodiments, isopropanol can be included in the foamable alcohol-based composition without reducing ethanol to maintain foam quality. That is, the total amount of antibacterial alcohol can be increased by adding isopropanol to the foamable alcohol-based composition in addition to ethanol. Addition of isopropanol is advantageous because it does not reduce the quality of the foam.

  In one or more embodiments, the amount of isopropanol is greater than about 3% by weight, in other embodiments at least about 3.2% by weight, in other embodiments at least about 3.3% by weight, in other embodiments At least about 3.5 wt%, and in other embodiments at least about 4 wt% (wt% based on the total weight of the foamable alcoholic composition).

  In one or more embodiments, the amount of isopropanol is greater than about 4.5 wt%, in other embodiments at least about 5 wt%, and in other embodiments at least about 5.5 wt% (wt% is Based on the total weight of the foamable alcohol-based composition).

  In one or more embodiments, if too much isopropanol is present, the foam quality may be reduced. Thus, in one or more embodiments, the amount of isopropanol is about 15 wt% or less, in other embodiments about 12 wt% or less, in other embodiments about 10 wt% or less, in other embodiments about 9.5 wt%. % Or less, and in other embodiments about 9% by weight or less (% by weight is based on the total weight of the foamable alcohol-based composition).

  In one or more embodiments, the amount of isopropanol is about 8.5 wt% or less, in other embodiments about 8 wt% or less, and in other embodiments about 7.5 wt% or less (wt% is Based on the total weight of the foamable alcohol-based composition).

  In one or more embodiments, foam stability and / or foam quality is maintained when the amount of isopropanol is selected based on the amount of foaming surfactant present. In one or more embodiments, the isopropanol weight percent is about 4: 1 or less, in other embodiments about 3.5: 1 or less, in other embodiments about 3: 1, based on the weight percent of the foaming surfactant. It is as follows. In one or more embodiments, the isopropanol weight percent is no more than about 2.5: 1, in other embodiments no more than about 2.25: 1, and in other embodiments no more than about 2 based on the weight percent of the foaming surfactant. : 1 or less. In one or more embodiments, the isopropanol weight percent is no more than about 1.5: 1, in other embodiments no more than about 1.25: 1, in other embodiments no more than about 1 based on the weight percent of the foaming surfactant. : 1 or less.

  As mentioned above, certain commercially available ethanol products contain a small amount of isopropanol as a denaturing agent. For example, SDA-3C contains about 5% by weight isopropanol. For purposes herein, unless otherwise stated, the amount of isopropanol includes both isopropanol derived from denatured ethanol and isopropanol added to the alcoholic composition independently of ethanol.

  In certain embodiments, the alcohol-based composition of the present invention further comprises at least one foam stabilizer. In one or more embodiments, the foam stabilizer may be polymeric or non-polymeric. In one or more embodiments, the foam stabilizer can be selected from polymeric or oligomeric foam stabilizers. In one or more embodiments, the foam stabilizer comprises a cationic oligomer or polymer.

  Foam stabilizers that can complement the stabilizing effect of isopropanol and function to improve foam quality and / or stability include vinyl caprolactam (VCL), vinylpyrrolidone (VP), and dialkylaminoalkyl acrylates. And terpolymers (VP / vinyl caprolactam / dimethylaminopropyl methacrylamide copolymer, etc.). Examples of the polymeric foaming stabilizer include polyquaternium polymers. In general, polyquaternium polymers have been so named by the American Cosmetic Industry Association (CTFA). The polyquaternium polymer is characterized by having quaternary ammonium groups. Still other polymeric foam stabilizers include isobutylene / dimethylaminopropyl maleimide / ethoxylated maleimide / maleic acid copolymers. These and other foam stabilizers are sometimes referred to as film-forming polymers.

  Further foam stabilizers include (acrylamide / ammonium acrylate) copolymer, (acrylamide / DMAPA DMAPA / methoxymethacrylate PEG) copolymer, (acrylamide / acryloyldimethyltaurine sodium / acrylic acid) copolymer. , (Acrylamidopropyltrimonium chloride / acrylamide) copolymer, (acrylamidopropyltrimonium chloride / acrylate) copolymer, (acrylate / acetoacetoxyethyl methacrylate) copolymer, (acrylate / acrylamide) copolymer, ( (Acrylate / ammonium methacrylate) copolymer, (acrylate / t-butylacrylamide) copolymer, acrylate copolymer, (acrylate / alkyl succinate (C1-2) / hydro (Cyacrylate) copolymer, (acrylate / ethylamine oxide methacrylate) copolymer, (acrylate / lauryl acrylate / stearyl acrylate / ethylamine methacrylate oxide) copolymer, (acrylate / octylacrylamide) copolymer, (acrylate) / Octylacrylamide / diphenylamodimethicone) copolymer, (acrylate / polytrimethylsiloxy methacrylate) copolymer, (acrylate / stearyl acrylate / ethylamine oxide oxide) copolymer, (acrylate / trifluoropropyl methacrylate / (Polytrimethylsiloxy methacrylate) copolymer, (acrylate / VA) copolymer, (acrylate / VP) copolymer, (adipic acid / diethylenetriamine) copolymer (Adipic acid / dimethylaminohydroxypropyldiethylenetriamine) copolymer, (Adipic acid / epoxypropyldiethylenetriamine) copolymer, (Adipic acid / isophthalic acid / Neopentyl glycol / Trimethylolpropane) copolymer, (Allyl stearate / VA) copolymer, (aminoethyl phosphate acrylate / acrylate) copolymer, aminoethylpropanediol-acrylate / acrylamide) copolymer, (aminoethylpropanediol-AMPD-acrylate / diacetone acrylamide) copolymer Copolymer, (Ammonium VA / acrylate) copolymer, (Amodimethicone / silsesquioxane) copolymer, (AMPD-acrylate / diacetone acrylamide) copolymer, (AMP-acrylate / meta) (Allyl crylate) copolymer, (AMP-acrylate / alkyl acrylate (C1-18) / alkyl (C1-8) acrylamide) copolymer, (AMP-acrylate / diacetone acrylamide) copolymer, (AMP- Acrylate / dimethylaminoethyl methacrylate copolymer, Bacillus / (rice bran extract / soybean extract) fermentation broth, (behenyl methacrylate / ethylamine methacrylate oxide) copolymer, (bisbutoxyoxydimethicone / PEG-60) copolymer , (Bisisobutyl PEG-14 / Amodimethicone) copolymer, (Bisisobutyl PEG-15 / Amodimethicone) copolymer, (Butyl acrylate / Ethylhexyl methacrylate) copolymer, (Butyl acrylate / Hydroxy acrylate) Propyl dimethicone) Body, (ethylene / MAbutyl) copolymer, (PVM / MAbutyl) copolymer, (PVM / MA) copolymer (calcium / sodium) mixed salt, chitosan, chitosan lactate, (corn starch / acrylamide / Sodium acrylate) copolymer, dehydroxanthan gum, (diethylene glycol amine / epichlorohydrin / piperazine) copolymer, dimethicone crosspolymer, (dimethicone / silsesquioxane) copolymer, diphenylamodimethicone, (PVM / MA) Ethyl) copolymer, (ethyltrimonium methacrylate methacrylate / hydroxyethylacrylamide) copolymer, (hydrolyzed wheat protein / PVP) crosspolymer, hydroxypropyl dimethiconylpropyl acrylate copolymer, hydroxypropyl Monium hydrolyzed corn starch, (isobutylene / ethylmaleimide / hydroxyethylmaleimide) copolymer, (isobutylene / MA) copolymer, (isobutyl methacrylate / trifluoroethyl methacrylate / bishydroxypropyl dimethicone acrylate) copolymer , (PVM / MA isopropyl) copolymer, lauryl acrylate crosspolymer, (lauryl methacrylate / glycol dimethacrylate) crosspolymer, lauryl PEG-9 polydimethylsiloxyethyl dimethicone, (methacrylic acid / sodium acrylamidomethylpropanesulfonate) ) Copolymer, (methacryloxyethyl betaine / acrylate) copolymer, (methoxyamodimethicone / silsesquioxane) copolymer, methoxy PEG-114 / polyε Caprolactone, (myristic acid / palmitic acid / stearic acid / ricinoleic acid / eicosandioic acid) glyceride, (octylacrylamide / acrylate / butylaminoethyl methacrylate) copolymer, (PEG-800 / polyvinyl alcohol) copolymer, PEG / PPG-25 / 25 dimethicone / acrylate) copolymer, (PEG-8 / SMDI) copolymer, polyacrylamide, polyacrylate-6, polyacrylate-8, polyacrylate-9, polyacrylate -15, polyacrylate-16, polyacrylate-17, polyacrylate-18, polyacrylate-19, (polybeta-alanine / glutaric acid) crosspolymer, polybutylene terephthalate, polyester-1, polyacrylic acid Ethyl, polyethylene Terephthalate, polyimide-1, polymethacryloylethylbetaine, polypentaerythrityl terephthalate, polyperfluoroperhydrophenanthrene, (polyquaternium-4 / hydroxypropyl starch) copolymer, polyurethane-1, polyurethane-6, polyurethane-10, polyurethane -18, polyurethane-19, polyvinyl acetate, polyvinyl butyral, polyvinyl caprolactam, polyvinyl formamide, polyvinyl imidazolinium acetate, polyvinyl methyl ether, (PVM / MA) copolymer butyl ester potassium salt, (PVM / MA) co Polymer ethyl ester potassium salt, PPG-70 polyglyceryl-10 ether, (PPG-12 / SMDI) copolymer, (PPG-51 / SMDI) copolymer , (PVM / MA) copolymer, (PVP / VA / itaconic acid) copolymer, (PVP / VA / vinyl propionate) copolymer, lysobian gum, rosin acrylate, shellac, (silicone quaternium-16 / Glycidoxy dimethicone) crosspolymer, (PVM / MA) copolymer butyl ester sodium salt, (PVM / MA ethyl) copolymer sodium, sodium polyacrylate, poly-γ-glutamate sodium, phthalate soy protein, Karaya gum, (terephthalic acid / isophthalic acid / sodium isophthalic acid sulfonate / glycol) copolymer, trimethylolpropane triacrylate, trimethylsiloxysilylcarbamoyl pullulan, (VA / crotonato) copolymer, (VA / crotonato / methacryloxy) Benzo Phenone-1) copolymer, (VA / crotonate / vinyl neodecanoate) copolymer, (VA / crotonate / vinyl propionate) copolymer, (VA / DBM) copolymer, (VA / vinyl butylbenzoate) / Crotonate) copolymer, (vinylamine / vinyl alcohol) copolymer, (vinylcaprolactam / VP / dimethylaminoethyl methacrylate) copolymer, (VP / acrylate / lauryl methacrylate) copolymer, (VP / methacrylic) Acid dimethylaminoethyl) copolymer, (VP / acrylic acid DMAPA) copolymer, (VP / hexadecene) copolymer, (VP / methacrylamide / vinylimidazole) copolymer, (VP / VA) copolymer , (VP / vinyl caprolactam / DMAPA acrylic acid) copolymer, yeast palmitate And silicon-based polymers or resins such as phenylpropyldimethylsiloxysilicic acid, trimethylsiloxysilicic acid, cyclopentasiloxane, siloxysilicate diisostearoyltrimethylolpropane, vinyl dimethicone crosspolymer mixture, and alkyl cetearyl dimethicone crosspolymer. Can be mentioned.

  In one or more embodiments, suitable foam stabilizers include oxyalkylene polymers. Oxyalkylene polymers include poly (propylene oxide) homopolymers, poly (ethylene oxide) homopolymers, and copolymers of poly (propylene oxide) and poly (ethylene oxide). In one or more embodiments, the foamable composition comprises one or more poly (ethylene oxide) homopolymer. In one or more embodiments, the poly (ethylene oxide) homopolymer has an average number of repeating oxyalkylene units of from about 5 to about 50, and in other embodiments from about 7 to about 45. In one or more embodiments, the average number of repeating oxyethylene units is from about 30 to about 35.

  In one or more embodiments, the foam stabilizer is present in an amount (active amount) of about 0 to about 4% by weight, based on the total weight of the alcoholic composition. In another aspect, the foam stabilizer is present in an amount of about 0.01 to about 3 weight percent, based on the total weight of the alcoholic composition, and in yet another aspect, the foam stabilizer is the total weight of the alcoholic composition. It is present in an amount of from about 0.02 to about 2% by weight.

  In one aspect, the foam stabilizer is added directly to the alcohol-based composition. In one or more other embodiments, the foam stabilizer is added to the alcoholic composition as a solution or emulsion. That is, the foam stabilizer may be premixed with the carrier to form a foam stabilizer solution or emulsion under the condition that the carrier does not adversely affect the foamability of the alcohol-based composition. Examples of carriers include water, alcohols, glycols (such as propylene glycol or ethylene glycol), ketones, linear and / or cyclic hydrocarbons, triglycerides, carbonates, silicones, alkenes, esters ( Acetate, benzoate, fatty acid ester, glyceryl ester, etc.), ethers, amides, polyethylene glycols, and PEG / PPG copolymers, inorganic salt solutions (eg, physiological saline), and mixtures thereof. . Of course, when the foam stabilizer is premixed to form a foam stabilizer solution or emulsion, the amount of solution or emulsion added to the alcohol-based composition is such that the amount of foam stabilizer falls within the above range. Selected.

  As described above, the foamable alcohol-based composition of the present invention comprises a combination of isopropanol and at least one other alcohol and a branched PEG dimethicone foamable surfactant. The alcohol-based composition of the present invention may further contain a wide variety of optional components as long as they do not adversely affect the foamability or foam stability of the alcohol-based composition. CTFA's International Cosmetic Ingredient Dictionary and Handbook, 11th edition, 20th, and CTFA's International Buyer's Guide (2004) (this document is incorporated herein by reference in its entirety) Describes a wide variety of cosmetic and pharmaceutical ingredients commonly used in the skin care industry, including but not limited to those suitable for use in the compositions of the present invention. Yes. In order to enhance or change the quality and properties of the foam, to change the feel of the final formulation when applied and / or dried, to increase the persistence of alcohol and the effect of microorganisms, In order to solubilize other components such as sunscreen and to relieve irritation, the alcohol-based composition may contain an auxiliary surfactant.

  In certain embodiments, the alcohol-based composition includes one or more wetting agents. Examples of wetting agents include propylene glycol, dipropylene glycol, hexylene glycol, 1,4-dihydroxyhexane, 1,2,6-hexanetriol, 1,2-octanediol, sorbitol, butylene glycol, propanediols ( Methylpropanediol, etc.), dipropylene glycol, triethylene glycol, glycerin (glycerol), polyethylene glycol, ethoxydiglycol, polyethylene sorbitol, and combinations thereof. Examples of other wetting agents include glycolic acid, glycolate, lactate, lactic acid, sodium pyrrolidonecarboxylate, hyaluronic acid, chitin, tocopherol acetate, and the like. In one or more embodiments, the wetting agent is present in an amount of 0 to about 20% by weight, based on the total weight of the alcoholic composition. In one or more embodiments, the wetting agent is present in an amount of about 0.1 to about 10% by weight, in other embodiments from about 0.25 to about 8% by weight, in other embodiments from about 0.4 to about 5%. % By weight, in other embodiments from about 0.5 to about 2.5% by weight (% by weight based on the total weight of the alcoholic composition). In one or more embodiments, the wetting agent is present in an amount of from 0 to about 1 wt%, in other embodiments from about 0.01 to about 0.5 wt%, in other embodiments from about 0.025 to about 0.0. Present in an amount of 2 wt%, in other embodiments from about 0.4 to about 5 wt%, in other embodiments from about 0.05 to about 0.1 wt% (wt% is based on the total weight of the alcoholic composition). ).

  In these or other embodiments, the alcohol-based composition includes one or more conditioning or moisturizing esters. Examples of esters include cetyl myristate, cetyl myristoleate, and other cetyl esters, diisopropyl sebacate, and isopropyl myristate. In one aspect, the ester is present in an amount up to 10% by weight based on the total weight of the alcoholic composition. In another embodiment, the ester is present in an amount of about 0.5 to about 5 wt%, in another embodiment about 1 to about 2 wt% (wt% is based on the total weight of the alcoholic composition). In one or more embodiments, the ester is present in an amount of from 0 to about 5 wt%, in other embodiments from about 0.05 to about 2 wt%, in other embodiments from about 0.1 to about 1 wt% ( % By weight based on the total weight of the alcoholic composition)

  In one or more embodiments, the alcohol-based composition includes one or more emulsifiers. Examples of emulsifiers include stearyl alcohol, sorbitan oleate, trideceth-2, poloxamer, and PEG / PPG≡20 / 6 dimethicone. In one aspect, the emulsifier is present in an amount up to about 10% by weight based on the total weight of the alcoholic composition. In another embodiment, the emulsifier is present in an amount of about 0.1 to about 5 wt%, in another embodiment about 0.5 to about 2 wt% (wt% is based on the total weight of the alcoholic composition).

  In one or more aspects, the alcohol-based composition further comprises one or more of PEG-32 and cocoyl arginine ethyl PCA (CAE).

  In one or more embodiments, PEG-32 is present in an amount of about 0 to about 5% by weight, based on the total weight of the alcoholic composition. In one or more embodiments, the amount of PEG-32 is about 0.2 to about 2% by weight based on the total weight of the alcoholic composition. In another aspect, PEG-32 is present in an amount of about 0.3 to about 1.5% by weight based on the total weight of the alcoholic composition.

  In one or more embodiments, the tocopherol acetate is present in an amount from 0 to about 5 wt%, in other embodiments from about 0.005 to about 2.5 wt% (wt% is based on the total weight of the alcoholic composition). . In one or more embodiments, the tocopherol acetate is present in an amount of from about 0.005 to about 0.5 wt%, and in other embodiments from about 0.1 to about 0.25 wt% (wt% is the alcoholic composition). Based on the total weight).

  In one or more embodiments, the CAE is present in an amount from about 0 to about 0.5 wt%, in other embodiments from about 0.05 to about 0.40 wt% (wt% is the total weight of the alcoholic composition). Criteria). In one aspect, the CAE is present in an amount of about 0.05 to about 0.22% by weight, and in another aspect about 0.15 to about 0.20% by weight (% by weight is based on the total weight of the alcoholic composition). ).

  In one or more embodiments, the composition may include supplemental antimicrobial agents in addition to ethanol and isopropanol. Examples of (but not limited to) supplemental antibacterial agents include triclosan (also known as 5-chloro-2 (2,4-dichlorophenoxy) phenol, under the trade name IRGASAN®) Chloroxylenol (also known as 4-chloro-3,5-xylenol, available from Nipa Laboratories, Inc. under the trade name NIPACIDE® MX or PX); hexetidine (available from Ciba-Geigy Corporation); 5-amino-1,3-bis (2-ethylhexyl) -5-methyl-hexahydropyrimidine); chlorhexidine salts such as chlorhexidine gluconate (CHG) and N, N ″ -bis (4-chlorophenyl) ) -3,12-diimino-2,4,11,14-tetraazatetradecandi Salts of midiamide; 2-bromo-2-nitropropane-1,3-diol; benzalkonium chloride; cetylpyridinium chloride; alkylbenzyldimethylammonium chloride; iodine; phenol derivatives; povidone iodine (such as polyvinylpyrrolidinone-iodine); Hydantoin and its derivatives (2,4-imidazolidinedione and its derivatives as well as dimethylol-5,5-dimethylhydantoin (also known as DMDM hydantoin or Glydant)); phenoxyethanol; 1- (3-chloroallyl) -3 The cis isomer of 5,5,6-triaza-1-azoniaadamantan chloride (also known as Quotanium-15, available from Dow Chemical Company under the trade name DOWCIL ™ 2000) ); Diazolidinyl urea; benzethonium chloride; methyl benzethonium chloride; and mixtures thereof. If an auxiliary antimicrobial agent is used, the auxiliary antimicrobial agent may be present in an amount of about 0.05 to about 1% by weight, based on the total weight of the alcoholic composition. In one or more embodiments, the amount of supplemental antibacterial agent is from about 0.1 to about 0.8% by weight, and in other embodiments from about 0.2 to about 0.6% by weight (% by weight is the alcoholic composition). Based on the total weight). In one or more embodiments, the composition of the present invention comprises CHG.

  The alcohol-based composition of the present invention may further contain a wide variety of topical drug active ingredients as optional ingredients as long as they do not adversely affect the foamability or foam stability of the alcohol composition.

  In one or more embodiments, the remaining portion of the alcohol-based composition includes water or other suitable solvent.

  The alcohol-based composition can be prepared by simply mixing the above components. The order of addition is not particularly limited and is easily recognized by those skilled in the art. In one or more embodiments, the resulting mixture is a clear and homogeneous solution.

  In one or more embodiments, the viscosity of the composition is less than about 100 mPas, in one embodiment less than about 50 mPas, and in another embodiment less than about 25 mPas (Brook using an RV spindle and / or LV spindle at 22 ° C. ± 3 ° C.). When measured with a field RV viscometer).

  In one or more embodiments, the foamable composition of the present invention may be expressed as a transparent liquid. In one aspect, when the antimicrobial composition is in liquid form, the antimicrobial composition has a solids content of less than about 6 percent, in another embodiment, less than about 5 percent, in yet another embodiment, less than about 4 percent, Less than about 3 percent in another embodiment, less than about 2 percent in another embodiment, and less than about 1 percent in yet another embodiment. The proportion of solids can be determined by various methods known in the art.

Conveniently, the total amount of C _1-6 monohydric alcohol (ie antimicrobial alcohol) can be increased without sacrificing foam quality and / or stability. Therefore, the composition of the present invention can enhance the rapid antibacterial activity as compared to the foam composition having the same foam quality and / or stability but having a lower content of C _1-6 monohydric alcohol. . In one or more embodiments, the antibacterial alcohol-based composition is effective in killing Gram-negative and Gram-positive bacteria, fungi, parasites, crusted and crustless viruses. In one or more embodiments, the antimicrobial alcohol-based composition comprises Staphylococcus aureus, methicillin-resistant Staphylococcus aureus, Escherichia coli, Pseudomonas aeruginosa, Serratia marcescens. It has rapid antibacterial efficacy against bacteria such as Candida albicans and Aspergillus niger. In one or more embodiments, the antibacterial alcohol-based composition has a rapid potency against skin microflora, including skin resident and transient microbiota.

  Accordingly, the present invention further provides a method for killing or inactivating microorganisms present on a surface comprising applying to the surface an effective amount of an antimicrobial alcohol-based composition as described herein. Antibacterial alcohol-based compositions can be used on a wide variety of surfaces or substrates, including inanimate surfaces, biological surfaces (such as skin), porous surfaces, and non-porous surfaces.

  In one or more embodiments, the antimicrobial alcohol-based composition of the present invention is used topically on mammalian skin. In one aspect, the method of contacting the antibacterial alcohol-based composition with microorganisms present on human skin applies a quantity of the composition to the skin and leaves the composition in contact with the skin for an appropriate amount of time. Including doing. In other embodiments, the composition may be spread over the surface of the skin, rubbed, rinsed, dried by evaporation, or wiped off.

  Accordingly, the present invention provides a method for skin disinfection comprising contacting an effective amount of a non-aerosol foaming alcohol-based composition with mammalian skin. The non-aerosol foamable alcohol-based composition is selected from the group consisting of at least about 60% by weight ethanol and PEG-10 to PEG-12 dimethicone surfactant based on the total weight of the antimicrobial alcohol-based composition. About 0.75 to about 15% by weight of the branched foamable surfactant, based on the total weight of the foamable composition, and at least about 3% by weight of isopropanol based on the total weight of the foamable composition. . In one or more aspects, the present invention provides a method of disinfecting a hand.

  The antibacterial alcohol-based composition of the present invention can be advantageously used as a hand-washing agent for medical staff. In one or more embodiments, the present invention relates to FDA's Tentative Final Monograph for Healthcare Antiseptic Drug Products (FFM) (Federal Register 59 [116], 1994). Jun. 17th, 1991: 31402-31452), an antibacterial alcohol-based composition is provided.

  In one or more embodiments, the alcohol-based antimicrobial composition of the present invention is useful as a surgical hand-washing composition. The requirements for in vitro and in vivo testing of surgical handwashes are as follows: FDA's Tentative Final Monograph for Healthcare Antiseptic Drug Products (TFM) (Federal Register 59 [116], June 1994 17th: 31445-31448). The in vivo test method described from page 31445 is hereinafter referred to as the FDA TFM surgical hand wash test. The antibacterial efficacy of surgical handwashes can be tested by any suitable test that has been found to demonstrate sufficient sterilization of the resident skin flora. Examples of such tests include ASTM E1115-02 “Standard Test Method for Evaluation of Surgical Hand Scrub Formulations” (ASTM International) and EN12791: 2005. "Chemical disinfectants and antiseptics, Surgical hand disinfection, Test method and requirement (phase 2, step 2)" (Chemical disinfectant and disinfectant, hand sterilization during operation, test method and requirement (phase 2, step 2)) " CEN: Comitee Europeen de Normalization, Brussels, Belgium).

  The antimicrobial composition and method aspects of the present invention provide rapid antimicrobial efficacy with a single use. In one or more embodiments, due to rapid and broad spectrum antimicrobial efficacy, the composition is ASTM E1173-01 “Standard Test Method for Evaluation of Preoperative, Precatheterization, or Preinjection Skin Preparations (preoperative, precatheter, or preinjection). Standard Test Method for Evaluating Dermal Formulations for Skin Care ”and FDA ’s Tentative Final Monograph for Healthcare Antiseptic Drug Products (TFM) (TFM) (Federal Register 59 [116], 1994) June 17, 1991: 31402-31452) and is useful as a dermatological preparation as tested.

  In one or more aspects, the present invention relates to EN1040 for basic bactericidal activity, EN1275 for basic fungicidal activity, EN1500 for the activity of products for use as sanitary scrubbing handwashes, and bactericidal activity for M. tuberculosis. An antimicrobial composition is provided that meets one or more of the criteria of EN 14348, EN 14476 for virucidal activity, and EN 12791 for hand sterilization during surgery.

  A propellant may be used to produce a stable foam, but advantageously no propellant is required. In certain embodiments, the amount of propellant is less than about 1000 ppm by weight based on the total weight of the alcoholic composition. In one aspect, the alcohol-based composition is substantially free of propellants (such as hydrocarbon propellants). “Substantially free” means that the amount of propellant in the alcoholic composition is less than about 100 ppm by weight based on the total weight of the alcoholic composition.

  The foamable composition of the present invention can be used in any type of dispenser commonly used for foam products. Conveniently, the foamable composition may be foamed, if necessary, by aerosolizing the composition, but the aerosolized product is not essential for foaming. Any dispenser capable of mixing the foamable alcohol-based composition with air or an inert gas may be used. Inert gases include gases that do not substantially react with the foamable composition or otherwise have a detrimental effect. Examples of inert gases include nitrogen, argon, xenon, krypton, helium, neon, and radon.

  The foamable composition of the present invention can be used in any type of dispenser commonly used for foam products. Conveniently, the foamable composition may be foamed with an aerosol if necessary, but the aerosol is not essential for foaming. Any dispenser capable of mixing the foamable alcohol-based composition with air or an inert gas may be used. Inert gases include gases that do not substantially react with the foamable composition or otherwise have a detrimental effect. Examples of inert gases include nitrogen, argon, xenon, krypton, helium, neon, and radon.

  In general, a foamed composition can be produced using a nozzle adapted to include and / or maximize the air contained in the liquid composition of the invention to be ejected. Many suitable nozzles are available in the art and generally include, but are not limited to, meanders located between the liquid composition and the pressurized portion of the dispenser that can extrude the liquid composition through the nozzle. Paths, fine needle holes, fine screens and / or porous fabrics are included. Thus, the turbulent flow generated by various means takes in small air bubbles in the liquid composition in the process of taking out, and thereby the foamed composition is taken out. These foamable compositions provide a stable foam that bursts when pressure is applied (such as when a user rubs the hand or when applied to a surface). Such a device is available from WaterGuard® Line by Airspr≡≡y®.

  In one or more embodiments, the alcohol-based composition is placed in a dispenser using a foaming pump that mixes the ambient air or inert gas with the alcohol-based composition in a mixing chamber and passes the mixture through a mesh screen. Used. Other non-aerosol foaming pumps are known and can be used.

  In one or more embodiments, the compositions of the present invention have improved foam stability compared to the same composition that does not contain an effective amount of isopropanol. Isopropanol acts as a foam stabilizer (ie increases foam stability) and is advantageous. In particular, when the foaming surfactant comprises branched PEG-10 to PEG-12 dimethicone, it has been found that the presence of isopropanol improves foam stability.

  The foam of the present invention has good foam quality and stability even when using a branched polyethoxylated dimethicone surfactant as the foaming surfactant, as long as the composition contains an effective amount of isopropanol. is there. The foamable composition of the present invention provides good foam quality and stability even when the amount of ethanol is 60% by weight or more. Embodiments of the present invention provide good foam quality and stability even when the amount of ethanol is 70% by weight or more. Surprisingly, considering that isopropanol is also an antibacterial alcohol, the foamable composition of the present invention provides good foam quality and stability even when the amount of alcohol is above 70% by weight. Embodiments of the present invention provide good foam quality and stability even when the amount of alcohol is 80% by weight or more.

Thus, the present invention provides a method of forming non-aerosol alcoholic foams with improved foam quality and / or stability. The method includes the step of combining a C _1-6 alcohol, a branched polyethoxylated dimethicone foaming surfactant, an effective amount of isopropanol that stabilizes the foam, and water to form a foamable composition; Here, the foamable composition contains at least 60% by weight of C _1-6 alcohol, based on the total weight of the foamable composition.

  In one or more embodiments, foam stability may be measured as the time it takes for the foamed composition to disintegrate and become liquid. This is sometimes called the drainage test method. Foams with good stability are advantageous because they collapse and become liquid, which tends to drip from the surface to which they are applied, the foaming pump, and / or the associated dispenser element.

  In one or more embodiments, foam stability may be evaluated in the following manner. The foamable mixture is passed through a non-aerosol foaming pump. Secure the Tygon® (or similar) tube to the tip of the pump to ensure no voids. Slowly activate the pump several times to presuction the pump, during which time the product pushed out by the pump is discarded. In one or more embodiments, the pump is pre-aspirated by operating the pump five times. After pre-pumping the pump, one or more test aliquots are pumped into the calibrated container. In one or more embodiments, the graduated container may be a conical centrifuge tube. In one or more embodiments, the centrifuge tube may be an approximately 100 milliliter (mL) centrifuge tube for oils. In one or more embodiments, about four test aliquots may be pumped into a calibrated container. Pumping this aliquot in a regular manner into a graduated container is beneficial for obtaining consistent results.

  As the foam collapses into a liquid, the liquid level in the calibrated container rises, which will be visually apparent. In one or more aspects, the time taken for the liquid level to rise to a predetermined point may be measured. For example, in one or more embodiments, when about 6 mL of a foamable composition is pumped into a tube using a 100 mL conical centrifuge tube for oils, it takes for the liquid level to rise to 3.5 mL. Record the time. The test may be repeated and the results averaged.

  In one or more embodiments, the foam stability of the foam produced when the foamable alcohol-based composition is passed through a non-aerosol foaming pump at room temperature is at least about 20 seconds, in other embodiments at least about 30 seconds. , In other embodiments at least about 1 minute, in other embodiments at least about 80 seconds, in other embodiments at least about 90 seconds, in other embodiments at least about 3 minutes. That is, in one or more embodiments, the alcohol-based composition maintains a foamy form for at least 3 minutes and does not collapse into a liquid form. In other embodiments, the foam stability is at least about 5 minutes, and in yet other embodiments, the foam stability is at least about 15 minutes. In one or more embodiments, the foam stability is at least as long as the time required for the composition to evaporate.

  In one or more embodiments, the foam quality may be measured by visual inspection. The average foam size and the relative ratio of large foam to small foam, foam height and density, and foam dissipation rate can be observed by visual inspection. In one or more aspects, the foam height can also be an indicator of foam quality. In one or more aspects, a visual rating scale may be established to assess foam quality.

  In one or more embodiments, the bubble height may be measured. As mentioned above, the initial foam height may be used as an indicator of foam quality. In one or more embodiments, changes in bubble height over time may also be measured.

  Of course, various methods may be used to measure the bubble height. In one or more aspects, the following method may be used. Foam is generated from each composition using a foaming pump nozzle. In one or more embodiments, the pump may be product number F2, F2-L11 255/150, available from Albea (formerly Airspray International Inc.). Using a small bottle, collect the foam from the pump dispenser and measure the foam height. The exact size and composition of the vial is not limited as long as it is consistent from one test sample to the next. In one or more embodiments, the vial may be made of glass and may have a height of 40 or 80 millimeters (mm), an inner diameter of 25 mm, and an outer diameter of 27 mm.

  Between each sample, the pump may be flushed by passing water through the pump until it is cleaned with deionized water or ethanol. The pump dip tube is then removed from the water and the residual water is pumped out and dried and then placed in the composition to be tested.

  Run the pump three times to pre-suction, then three more times to fill the nozzle with the solution to ensure system preparation. Three test aliquots of foam are collected in a collection vial by slowly operating the pump at a rate of about 1 second for each pump. Place the foamed jar on a flat surface, start a timer and measure the approximate height of the foam using a small ruler in millimeters, ignoring the height of the remaining unfoamed composition .

  The time taken to measure the foam height should be consistent and in one or more embodiments is about 5 seconds. This can be referred to as the initial bubble height. Any composition that produces foam that is not stable for at least the time required to measure the foam height is considered unstable and the foam height rating may be 0 mm. Furthermore, when there is no foam at any point (center, etc.) at the top of the solution, the evaluation may be 0 mm. In one or more embodiments, the foam height was recorded after a predetermined time (such as after 1 minute, 3 minutes, 5 minutes, etc.) to evaluate foam stability.

  In one or more embodiments, the foamable composition of the present invention forms a foam having a measurable initial foam height. In one or more embodiments, the foamable composition of the present invention forms a foam whose foam height is measurable after about 1 minute. In one or more embodiments, the foamable composition of the present invention forms a foam whose foam height is measurable after about 3 minutes. In one or more embodiments, the foamable composition of the present invention forms a foam whose foam height is measurable after about 5 minutes.

  In one or more embodiments, the foam formed from the composition of the present invention has a higher initial foam height than the foam formed from an equivalent composition that does not contain isopropanol.

In order to demonstrate the practice of the present invention, the following examples have been prepared and tested. However, these examples should not be construed as limiting the scope of the invention, and the claims define the invention.
<Example>

  Test A combines the amounts of water shown in the table below, various amounts of isopropanol, and about 74.1 grams (g) of SDA-3C, and slow to moderate speeds until a homogeneous mixture is obtained. Six samples were prepared by stirring at SDA-3C contained about 95% (v / v) ethanol and 5% (v / v) isopropanol. In the table below, the indicated amount of isopropanol is the amount added and does not include isopropanol contained in SDA-3C. Next, a branched PEG-10 dimethicone foaming surfactant (obtained under the trade name Silsurf E1310 from Siltech Corporation) in an amount of 0.5-4 grams (the same amount was used in all examples) was added to water. And dispersed in an alcohol mixture and mixed until a homogeneous dispersion was obtained. Water was added and mixed as needed to make the total amount 100 grams. The solution was stirred until a homogeneous mixture was obtained. The concentration of each component is summarized in the table below. The term “qs” indicates an amount sufficient to total 100%.

  The foamable mixture was passed through an Airspray® foam pump. Using a 100 mL graduated oil centrifuge tube, tubing, and stopwatch, the foam stability was evaluated as described below. The results are summarized in Table 2.

  The preparation to be tested (about 300 ml) was placed in a 535 ml foaming bottle and a foaming pump was fastened to the bottle. A 4 inch Tygon® tube was secured to the tip of the pump to ensure no voids. The portion of the tube covering the tip of the pump was about 5/8 inch.

  To pre-suck the pump, the pump was slowly activated 5 times and the extruded product was discarded. The stopwatch was started immediately after the pump was pre-aspirated.

  The pump was operated slowly and evenly for about 8-10 seconds, and four aliquots of the foamed sample were pumped into a conical graduated centrifuge tube (2 seconds each).

  As the foam collapsed and became liquid, the liquid level in the centrifuge tube rose. When the liquid level at the bottom of the centrifuge tube rose to 3.5 mL, the stopwatch was stopped and the time was recorded. The test was repeated and the results averaged.

  In Test B, six types of samples were prepared in the same manner as described for Test A, except that linear PEG-10 dimethicone surfactant was used instead of the branched foaming surfactant. Linear PEG-10 dimethicone surfactant was obtained from Siltech Corporation under the trade name Silsurf DI-1010. This foamable mixture was passed through a foaming pump and evaluated in the same manner as in Example 1. The results are summarized in Table 2.

  In Test C, six samples were prepared in the same manner as described for Test A, except that linear PEG-12 dimethicone surfactant was used instead of the branched foaming surfactant.

  In Test D, six types of samples were prepared in the same manner as described for Test A except that a silicone quaternary surfactant was used instead of the branched foaming surfactant. Silicone quaternary surfactants were obtained from Siltech Corporation under the trade name Silquat.

In Test E, six samples were prepared in the same manner as described for Test A, except that a silane surfactant was used instead of the branched foaming surfactant. The silane surfactant was obtained from Grant Industries under the name BisPEG-18 methyl ether dimethylsilane according to the International Nomenclature for Cosmetic Materials (INCI).

  Foam stability was evaluated by the following method. The foamable mixture was passed through a non-aerosol foaming pump. A Tygon® (or similar) tube was secured to the tip of the pump to ensure no voids. The pump was pre-aspirated by slowly operating the pump several times, and the product extruded at this time was discarded. In one or more embodiments, the pump was pre-aspirated by operating the pump five times. After pre-pumping the pump, one or more test aliquots were pumped into the calibrated container. In one or more embodiments, the calibrated container was a conical centrifuge tube. In one or more embodiments, the centrifuge tube was an approximately 100 milliliter (mL) oil centrifuge tube. In one or more embodiments, about four test aliquots were pumped into a graduated container. Pumping this aliquot in a fixed manner into a graduated container was beneficial to obtain consistent results.

  When the foam collapsed into a liquid, the liquid level in the calibrated container rose, which was visually evident. In one or more embodiments, the time taken for the liquid level to rise to a predetermined point was measured. For example, in one or more embodiments, the liquid level rises to 3.5 mL when about 6 mL of foamable composition is pumped into the tube using a 100 mL conical centrifuge tube for oils. Time was recorded. The test was repeated and the results averaged.

  Reference is now made to the drawings. FIG. 1 is a graphical representation of foam stability for the Example of Test A. FIG. 2 is a graphical representation of foam stability for the test B example. It can be seen that when linear PEG-10 dimethicone surfactant is used, foam stability decreases as IPA concentration increases. However, when branched PEG-10 dimethicone is used, foam stability is improved when the IPA concentration is about 2 to about 5% by weight.

  Various modifications and alterations will become apparent to those skilled in the art without departing from the scope and spirit of the invention. The present invention is not formally limited to the exemplary embodiments described herein.

Claims (65)

A non-aerosol foaming alcohol-based composition comprising:
At least about 40% ethanol by weight based on the total weight of the foamable composition;
A branched foamable surfactant selected from the group consisting of about 0.75 to about 15% by weight PEG-8 to PEG-12 dimethicone surfactant, based on the total weight of the foamable composition;
A composition comprising at least about 3% by weight of isopropanol, based on the total weight of the foamable composition.   2. The composition of claim 1, comprising at least about 50% ethanol by weight based on the total weight of the foamable alcohol-based composition.   2. The composition of claim 1, comprising at least about 60% ethanol by weight based on the total weight of the foamable alcoholic composition.   2. The composition of claim 1 comprising at least about 65% ethanol by weight based on the total weight of the foamable alcohol-based composition. The composition according to any one of claims 1 to 4, wherein the foamable surfactant is selected from compounds represented by the following formula:
^{_{R 2 -Si (CH 3) 2}} - [O-Si (CH 3) 2] a - [O-Si (CH 3) R 3] b -O-Si (CH 3) 2 -R 2
Wherein R ² and R ³ independently comprise a methyl group or a group represented by the following formula:
_{- (CH 2) 3 -O- (} CH 2 CH 2 O) c - [CH 2 CH (CH 3) O] d - (CH 2 CH 2 O) e H
(However, at least one R ³ is not CH ₃ , a is an integer of about 3 to about 21, b is an integer of about 1 to about 7, c is an integer of about 0 to about 40, and d is about 0 to about An integer of about 40, e is an integer of about 0 to about 40, where a ≧ 3 × b and c + d + e ≧ 5)).   6. A composition according to any one of the preceding claims comprising from about 1 to about 10% by weight of a foamable surfactant based on the total weight of the foamable alcoholic composition.   The composition according to any one of the preceding claims, comprising from about 1.25 to about 8% by weight of a foamable surfactant, based on the total weight of the foamable alcoholic composition.   8. A composition according to any one of the preceding claims comprising from about 2 to about 5% by weight of a foamable surfactant, based on the total weight of the foamable alcoholic composition.   9. A composition according to any one of the preceding claims comprising at least about 3.2 wt% isopropanol based on the total weight of the foamable alcoholic composition.   10. A composition according to any one of the preceding claims comprising at least about 3.3 wt% isopropanol based on the total weight of the foamable alcoholic composition.   11. A composition according to any one of the preceding claims comprising at least about 3.5% by weight of isopropanol, based on the total weight of the foamable alcoholic composition.   12. A composition according to any preceding claim, comprising at least about 4% by weight of isopropanol based on the total weight of the foamable alcoholic composition.   13. A composition according to any one of the preceding claims comprising greater than about 4.5% by weight isopropanol based on the total weight of the foamable alcoholic composition.   14. A composition according to any one of the preceding claims comprising at least about 5% by weight isopropanol based on the total weight of the foamable alcoholic composition.   15. A composition according to any one of the preceding claims comprising at least about 5.5 wt% isopropanol based on the total weight of the foamable alcoholic composition.   16. A composition according to any one of the preceding claims comprising no more than about 12% isopropanol by weight based on the total weight of the foamable alcoholic composition.   17. A composition according to any one of the preceding claims comprising no more than about 10% by weight of isopropanol based on the total weight of the foamable alcoholic composition.   18. A composition according to any one of the preceding claims comprising no more than about 9.5% by weight of isopropanol based on the total weight of the foamable alcoholic composition.   19. A composition according to any one of the preceding claims comprising no more than about 9% by weight of isopropanol based on the total weight of the foamable alcoholic composition.   20. A composition according to any one of the preceding claims comprising no more than about 8.5 wt% isopropanol based on the total weight of the foamable alcoholic composition.   21. A composition according to any one of the preceding claims comprising no more than about 8% by weight isopropanol based on the total weight of the foamable alcoholic composition.   22. A composition according to any one of the preceding claims comprising about 7.5% or less isopropanol by weight based on the total weight of the foamable alcoholic composition.   23. The composition of any one of claims 1-22, wherein the weight percent of isopropanol is not greater than about 4: 1 based on the weight percent of the foaming surfactant.   24. The composition of any one of claims 1 to 23, wherein the weight percent of isopropanol is about 3.5: 1 or less based on the weight percent of the foaming surfactant.   25. The composition of any one of claims 1 to 24, wherein the weight percent of isopropanol is no greater than about 3: 1 based on the weight percent of the foaming surfactant.   26. The composition of any one of claims 1-25, wherein the weight percent of isopropanol is not greater than about 2.5: 1 based on the weight percent of the foaming surfactant.   27. The composition of any one of claims 1-26, wherein the weight percent of isopropanol is not greater than about 2.25: 1 based on the weight percent of the foaming surfactant.   28. The composition of any one of claims 1-27, wherein the weight percent of isopropanol is no greater than about 2: 1 based on the weight percent of the foaming surfactant.   29. The composition of any one of claims 1-28, wherein the weight percent of isopropanol is no greater than about 1.5: 1 relative to the weight percent of the foaming surfactant.   30. The composition of any one of claims 1-29, wherein the weight percent of isopropanol is not greater than about 1.25: 1 relative to the weight percent of the foaming surfactant.   31. The composition of any one of claims 1-30, wherein the weight percent of isopropanol is not greater than about 1: 1 relative to the weight percent of the foaming surfactant. A method of forming a stable non-aerosol alcoholic foam comprising:
At least about 40% by weight of ethanol, and about 0.75 to about 10% by weight of a foamed surfactant selected from the group consisting of branched PEG-8 to PEG-12 dimethicone surfactants and combinations thereof; Combining at least about 3 to about 15% by weight of isopropanol to form a foamable alcoholic composition (all proportions based on the total weight of the alcoholic composition);
Removing the alcohol-based composition using a non-aerosol foaming pump to form a foam, wherein the foam is 0-3 wt% isopropanol based on the total weight of the alcohol-based composition. Having improved stability compared to foams formed from equivalent compositions comprising: A method of forming a non-aerosol alcoholic foam comprising:
At least about 40% by weight of ethanol, and about 0.75 to about 10% by weight of a foamed surfactant selected from the group consisting of branched PEG-8 to PEG-12 dimethicone surfactants and combinations thereof; Combining at least about 3 to about 15% by weight of isopropanol to form a foamable alcoholic composition (all proportions based on the total weight of the alcoholic composition);
Removing the alcohol-based composition using a non-aerosol foaming pump to form a foam, wherein the foam is 0-3 wt% isopropanol based on the total weight of the alcohol-based composition. Having improved quality as compared to foams formed from equivalent compositions comprising: A method of forming a stable non-aerosol alcoholic foam comprising:
At least about 40% by weight of ethanol, and about 0.75 to about 10% by weight of a foamed surfactant selected from the group consisting of branched PEG-8 to PEG-12 dimethicone surfactants and combinations thereof; Combining at least about 3 to about 15% by weight of isopropanol to form a foamable alcoholic composition (all proportions based on the total weight of the alcoholic composition);
Removing the alcohol-based composition using a non-aerosol foaming pump to form a foam, wherein the foam comprises the same amount of ethanol and isopropanol, but the branched surfactant is linear. A process having improved stability compared to foam formed from a composition substituted with a planar polyethoxylated dimethicone surfactant. A method of forming a non-aerosol alcoholic foam comprising:
At least about 40% by weight of ethanol, and about 0.75 to about 10% by weight of a foamed surfactant selected from the group consisting of branched PEG-8 to PEG-12 dimethicone surfactants and combinations thereof; Combining at least about 3 to about 15% by weight of isopropanol to form a foamable alcoholic composition (all proportions based on the total weight of the alcoholic composition);
Removing the alcohol-based composition using a non-aerosol foaming pump to form a foam, wherein the foam comprises the same amount of ethanol and isopropanol, but the branched surfactant is linear. A method having improved quality compared to foam formed from a composition substituted with a polyethoxylated dimethicone surfactant.   36. The method of any one of claims 32-35, wherein the foamable alcohol-based composition comprises at least about 50% ethanol by weight based on the total weight of the foamable alcohol-based composition.   37. The method of any one of claims 32-36, wherein the foamable alcohol-based composition comprises at least about 60% ethanol by weight based on the total weight of the foamable alcohol-based composition.   38. The method of any one of claims 32-37, wherein the foamable alcohol-based composition comprises at least about 65 wt% ethanol based on the total weight of the foamable alcohol-based composition. 39. A method according to any one of claims 32-38, wherein the foamable surfactant is selected from compounds represented by the following formula:
^{_{R 2 -Si (CH 3) 2}} - [O-Si (CH 3) 2] a - [O-Si (CH 3) R 3] b -O-Si (CH 3) 2 -R 2
Wherein R ² and R ³ independently comprise a methyl group or a group represented by the following formula:
_{- (CH 2) 3 -O- (} CH 2 CH 2 O) c - [CH 2 CH (CH 3) O] d - (CH 2 CH 2 O) e H
(However, at least one R ³ is not CH ₃ , a is an integer of about 3 to about 21, b is an integer of about 1 to about 7, c is an integer of about 0 to about 40, and d is about 0 to about An integer of about 40, e is an integer of about 0 to about 40, where a ≧ 3 × b and c + d + e ≧ 5)).   40. The foamable alcohol-based composition according to any one of claims 32-39, wherein the foamable surfactant-based composition comprises from about 1 to about 10% by weight of the foamable surfactant, based on the total weight of the foamable alcohol-based composition. The method described in 1.   41. The foamable alcohol-based composition of any of claims 32-40, wherein the foamable alcohol-based composition comprises from about 1.25 to about 8% by weight of the foamable surfactant, based on the total weight of the foamable alcohol-based composition. The method according to one item.   42. The foamable alcohol-based composition according to any one of claims 32-41, wherein the foamable alcohol-based composition comprises from about 2 to about 5% by weight of the foamable surfactant, based on the total weight of the foamable alcohol-based composition. The method described in 1.   43. The method of any one of claims 32-42, wherein the foamable alcohol-based composition comprises at least about 3.2 wt% isopropanol, based on the total weight of the foamable alcohol-based composition.   44. The method of any one of claims 32-43, wherein the foamable alcohol-based composition comprises at least about 3.3 wt% isopropanol based on the total weight of the foamable alcohol-based composition.   45. The method of any one of claims 32-44, wherein the foamable alcohol-based composition comprises at least about 3.5 wt% isopropanol, based on the total weight of the foamable alcohol-based composition.   46. The method of any one of claims 32-45, wherein the foamable alcohol-based composition comprises at least about 4% by weight isopropanol, based on the total weight of the foamable alcohol-based composition.   47. The method of any one of claims 32-46, wherein the foamable alcohol-based composition comprises greater than about 4.5% by weight isopropanol, based on the total weight of the foamable alcohol-based composition.   48. The method of any one of claims 32-47, wherein the foamable alcohol-based composition comprises at least about 5% by weight isopropanol, based on the total weight of the foamable alcohol-based composition.   49. The method of any one of claims 32-48, wherein the foamable alcohol-based composition comprises at least about 5.5% by weight isopropanol based on the total weight of the foamable alcohol-based composition.   50. The method of any one of claims 32-49, wherein the foamable alcohol-based composition comprises about 12% or less isopropanol by weight based on the total weight of the foamable alcohol-based composition.   51. The method of any one of claims 32-50, wherein the foamable alcohol-based composition comprises about 10 wt% or less isopropanol based on the total weight of the foamable alcohol-based composition.   52. The method of any one of claims 32-51, wherein the foamable alcohol-based composition comprises about 9.5% or less isopropanol by weight based on the total weight of the foamable alcohol-based composition.   53. The method of any one of claims 32-52, wherein the foamable alcohol-based composition comprises about 9 wt% or less isopropanol based on the total weight of the foamable alcohol-based composition.   54. The method of any one of claims 32-53, wherein the foamable alcohol-based composition comprises about 8.5 wt% or less isopropanol based on the total weight of the foamable alcohol-based composition.   55. The method of any one of claims 32-54, wherein the foamable alcohol-based composition comprises about 8 wt% or less isopropanol based on the total weight of the foamable alcohol-based composition.   56. The method of any one of claims 32-55, wherein the foamable alcohol-based composition comprises about 7.5% or less by weight of isopropanol based on the total weight of the foamable alcohol-based composition.   57. The method of any one of claims 32-56, wherein the weight percent of isopropanol is not greater than about 4: 1 based on the weight percent of the foaming surfactant.   58. The method of any one of claims 32-57, wherein the weight percent of isopropanol is about 3.5: 1 or less relative to the weight percent of the foaming surfactant.   59. The method of any one of claims 32-58, wherein the weight percent of isopropanol is about 3: 1 or less based on the weight percent of the foamable surfactant.   60. The method of any one of claims 32-59, wherein the weight percent of isopropanol is not greater than about 2.5: 1 relative to the weight percent of the foaming surfactant.   61. The method of any one of claims 32-60, wherein the weight percent of isopropanol is not greater than about 2.25: 1 relative to the weight percent of the foaming surfactant.   62. The method of any one of claims 32-61, wherein the weight percent of isopropanol is no greater than about 2: 1 based on the weight percent of the foaming surfactant.   63. The method of any one of claims 32-62, wherein the weight percent of isopropanol is not greater than about 1.5: 1 relative to the weight percent of the foaming surfactant.   64. The method of any one of claims 32-63, wherein the weight percent of isopropanol is not greater than about 1.25: 1 relative to the weight percent of the foaming surfactant.   65. The method of any one of claims 32-64, wherein the weight percent of isopropanol is not greater than about 1: 1 relative to the weight percent of the foaming surfactant.