JP2017535612A5 - - Google Patents
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- Publication number
- JP2017535612A5 JP2017535612A5 JP2017545857A JP2017545857A JP2017535612A5 JP 2017535612 A5 JP2017535612 A5 JP 2017535612A5 JP 2017545857 A JP2017545857 A JP 2017545857A JP 2017545857 A JP2017545857 A JP 2017545857A JP 2017535612 A5 JP2017535612 A5 JP 2017535612A5
- Authority
- JP
- Japan
- Prior art keywords
- nasal
- disorder
- preparation
- riluzole
- disease
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- FTALBRSUTCGOEG-UHFFFAOYSA-N Riluzole Chemical compound C1=C(OC(F)(F)F)C=C2SC(N)=NC2=C1 FTALBRSUTCGOEG-UHFFFAOYSA-N 0.000 claims 7
- 229960004181 riluzole Drugs 0.000 claims 7
- 208000019901 Anxiety disease Diseases 0.000 claims 4
- 230000036506 anxiety Effects 0.000 claims 4
- 208000010877 cognitive disease Diseases 0.000 claims 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 3
- 208000024827 Alzheimer disease Diseases 0.000 claims 2
- 206010013142 Disinhibition Diseases 0.000 claims 2
- 201000011240 Frontotemporal dementia Diseases 0.000 claims 2
- 206010022998 Irritability Diseases 0.000 claims 2
- 208000035475 disorder Diseases 0.000 claims 2
- 230000000694 effects Effects 0.000 claims 2
- 230000002996 emotional effect Effects 0.000 claims 2
- 238000009472 formulation Methods 0.000 claims 2
- 208000027061 mild cognitive impairment Diseases 0.000 claims 2
- 239000000203 mixture Substances 0.000 claims 2
- 229940002612 prodrug Drugs 0.000 claims 2
- 239000000651 prodrug Substances 0.000 claims 2
- 230000001225 therapeutic effect Effects 0.000 claims 2
- 208000004998 Abdominal Pain Diseases 0.000 claims 1
- 206010000060 Abdominal distension Diseases 0.000 claims 1
- 206010001497 Agitation Diseases 0.000 claims 1
- 208000000044 Amnesia Diseases 0.000 claims 1
- 206010003591 Ataxia Diseases 0.000 claims 1
- 208000006096 Attention Deficit Disorder with Hyperactivity Diseases 0.000 claims 1
- 208000036864 Attention deficit/hyperactivity disease Diseases 0.000 claims 1
- 208000020925 Bipolar disease Diseases 0.000 claims 1
- 208000028698 Cognitive impairment Diseases 0.000 claims 1
- 206010010219 Compulsions Diseases 0.000 claims 1
- 206010012218 Delirium Diseases 0.000 claims 1
- 206010012289 Dementia Diseases 0.000 claims 1
- 206010012735 Diarrhoea Diseases 0.000 claims 1
- 208000000059 Dyspnea Diseases 0.000 claims 1
- 206010013975 Dyspnoeas Diseases 0.000 claims 1
- 208000030814 Eating disease Diseases 0.000 claims 1
- 208000019454 Feeding and Eating disease Diseases 0.000 claims 1
- 208000002339 Frontotemporal Lobar Degeneration Diseases 0.000 claims 1
- 208000023105 Huntington disease Diseases 0.000 claims 1
- 208000008454 Hyperhidrosis Diseases 0.000 claims 1
- 208000020358 Learning disease Diseases 0.000 claims 1
- 206010026749 Mania Diseases 0.000 claims 1
- 208000026139 Memory disease Diseases 0.000 claims 1
- 208000036626 Mental retardation Diseases 0.000 claims 1
- 208000019022 Mood disease Diseases 0.000 claims 1
- 206010028813 Nausea Diseases 0.000 claims 1
- 206010060860 Neurological symptom Diseases 0.000 claims 1
- 208000008589 Obesity Diseases 0.000 claims 1
- 206010029897 Obsessive thoughts Diseases 0.000 claims 1
- 208000021384 Obsessive-Compulsive disease Diseases 0.000 claims 1
- 206010033557 Palpitations Diseases 0.000 claims 1
- 208000018737 Parkinson disease Diseases 0.000 claims 1
- 206010034568 Peripheral coldness Diseases 0.000 claims 1
- 206010034912 Phobia Diseases 0.000 claims 1
- 206010036790 Productive cough Diseases 0.000 claims 1
- 206010037180 Psychiatric symptoms Diseases 0.000 claims 1
- 208000028017 Psychotic disease Diseases 0.000 claims 1
- 208000006289 Rett Syndrome Diseases 0.000 claims 1
- 206010039897 Sedation Diseases 0.000 claims 1
- 206010041250 Social phobia Diseases 0.000 claims 1
- 208000027520 Somatoform disease Diseases 0.000 claims 1
- 208000009415 Spinocerebellar Ataxias Diseases 0.000 claims 1
- 208000010112 Spinocerebellar Degenerations Diseases 0.000 claims 1
- 206010048327 Supranuclear palsy Diseases 0.000 claims 1
- 208000009205 Tinnitus Diseases 0.000 claims 1
- 210000001015 abdomen Anatomy 0.000 claims 1
- 206010000059 abdominal discomfort Diseases 0.000 claims 1
- 230000016571 aggressive behavior Effects 0.000 claims 1
- 238000013019 agitation Methods 0.000 claims 1
- 206010002026 amyotrophic lateral sclerosis Diseases 0.000 claims 1
- 208000015802 attention deficit-hyperactivity disease Diseases 0.000 claims 1
- 231100000870 cognitive problem Toxicity 0.000 claims 1
- 230000007423 decrease Effects 0.000 claims 1
- 230000013872 defecation Effects 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 235000014632 disordered eating Nutrition 0.000 claims 1
- 208000002173 dizziness Diseases 0.000 claims 1
- 206010013663 drug dependence Diseases 0.000 claims 1
- 206010013781 dry mouth Diseases 0.000 claims 1
- 230000004064 dysfunction Effects 0.000 claims 1
- 208000027700 hepatic dysfunction Diseases 0.000 claims 1
- 201000003636 hereditary ataxia Diseases 0.000 claims 1
- 208000035231 inattentive type attention deficit hyperactivity disease Diseases 0.000 claims 1
- 208000002551 irritable bowel syndrome Diseases 0.000 claims 1
- 201000003723 learning disability Diseases 0.000 claims 1
- 208000019423 liver disease Diseases 0.000 claims 1
- 230000005976 liver dysfunction Effects 0.000 claims 1
- 230000006984 memory degeneration Effects 0.000 claims 1
- 208000023060 memory loss Diseases 0.000 claims 1
- 230000036651 mood Effects 0.000 claims 1
- 210000003205 muscle Anatomy 0.000 claims 1
- 230000008693 nausea Effects 0.000 claims 1
- 208000015122 neurodegenerative disease Diseases 0.000 claims 1
- 231100000862 numbness Toxicity 0.000 claims 1
- 239000007935 oral tablet Substances 0.000 claims 1
- 229940096978 oral tablet Drugs 0.000 claims 1
- 208000027753 pain disease Diseases 0.000 claims 1
- 208000022821 personality disease Diseases 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 208000019899 phobic disease Diseases 0.000 claims 1
- 208000028173 post-traumatic stress disease Diseases 0.000 claims 1
- 230000003989 repetitive behavior Effects 0.000 claims 1
- 208000013406 repetitive behavior Diseases 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
- 208000013220 shortness of breath Diseases 0.000 claims 1
- 208000019116 sleep disease Diseases 0.000 claims 1
- 239000012453 solvate Substances 0.000 claims 1
- 208000024794 sputum Diseases 0.000 claims 1
- 210000003802 sputum Anatomy 0.000 claims 1
- 208000011117 substance-related disease Diseases 0.000 claims 1
- 231100000886 tinnitus Toxicity 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462083068P | 2014-11-21 | 2014-11-21 | |
| US62/083,068 | 2014-11-21 | ||
| PCT/US2015/061106 WO2016081466A1 (en) | 2014-11-21 | 2015-11-17 | Sublingual administration of riluzole |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2017535612A JP2017535612A (ja) | 2017-11-30 |
| JP2017535612A5 true JP2017535612A5 (Direct) | 2018-11-01 |
Family
ID=55077617
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017545857A Pending JP2017535612A (ja) | 2014-11-21 | 2015-11-17 | リルゾールの舌下投与 |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US20180153862A1 (Direct) |
| EP (1) | EP3220890A1 (Direct) |
| JP (1) | JP2017535612A (Direct) |
| KR (1) | KR20170137030A (Direct) |
| CN (1) | CN107735077A (Direct) |
| AU (1) | AU2015350142A1 (Direct) |
| BR (1) | BR112017010440A2 (Direct) |
| CA (1) | CA2967659A1 (Direct) |
| EA (1) | EA201791110A1 (Direct) |
| IL (1) | IL252283A0 (Direct) |
| MX (1) | MX2017006454A (Direct) |
| PH (1) | PH12017500933A1 (Direct) |
| SG (1) | SG11201703897SA (Direct) |
| WO (1) | WO2016081466A1 (Direct) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9925282B2 (en) | 2009-01-29 | 2018-03-27 | The General Hospital Corporation | Cromolyn derivatives and related methods of imaging and treatment |
| CA2928028A1 (en) | 2013-10-22 | 2015-04-30 | The General Hospital Corporation | Cromolyn derivatives and related methods of imaging and treatment |
| CA2967662A1 (en) | 2014-11-21 | 2016-05-26 | Biohaven Pharmaceutical Holding Company Ltd. | Sublingual formulation of riluzole |
| US9899038B2 (en) | 2016-06-30 | 2018-02-20 | Karen Elaine Khaleghi | Electronic notebook system |
| US20190240194A1 (en) | 2016-08-31 | 2019-08-08 | The General Hospital Corporation | Macrophages/microglia in neuro-inflammation associated with neurodegenerative diseases |
| EP3512509A1 (en) * | 2016-09-15 | 2019-07-24 | Skintech Life Science Limited | Sublingual or buccal administration of dim for treatment of skin diseases |
| JP7354123B2 (ja) | 2018-02-21 | 2023-10-02 | エイアイ・セラピューティクス・インコーポレーテッド | アピリモドとグルタミン酸作動薬を用いた併用療法 |
| US10235998B1 (en) | 2018-02-28 | 2019-03-19 | Karen Elaine Khaleghi | Health monitoring system and appliance |
| CA3096545A1 (en) * | 2018-04-09 | 2019-10-17 | The General Hospital Corporation | Combination therapies for the treatment of amyotropic lateral sclerosis and related disorders |
| US12364687B2 (en) * | 2018-05-27 | 2025-07-22 | Biohaven Therapeutics Ltd. | Use of riluzole oral disintegrating tablets for treating diseases |
| JP2021534160A (ja) * | 2018-08-16 | 2021-12-09 | バイオヘイブン・セラピューティクス・リミテッドBiohaven Therapeutics Ltd. | 疾患処置のためのリルゾール口腔内崩壊錠の使用 |
| SG11202106117SA (en) | 2018-12-10 | 2021-07-29 | Massachusetts Gen Hospital | Cromolyn esters and uses thereof |
| US10559307B1 (en) | 2019-02-13 | 2020-02-11 | Karen Elaine Khaleghi | Impaired operator detection and interlock apparatus |
| US12458622B2 (en) | 2020-04-06 | 2025-11-04 | The General Hospital Corporation | Methods of treatment of coronavirus-induced inflammation conditions |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2492258A1 (fr) * | 1980-10-17 | 1982-04-23 | Pharmindustrie | Nouveau medicament a base d'amino-2 trifluoromethoxy-6 benzothiazole |
| US5837287A (en) * | 1994-10-28 | 1998-11-17 | R P Scherer Corporation | Process for preparing solid pharmaceutical dosage forms |
| FR2787028B1 (fr) * | 1998-12-15 | 2002-10-18 | Aventis Pharma Sa | Utilisation du riluzole dans le traitement des traumatismes acoustiques |
| SI1187612T1 (en) * | 1999-06-04 | 2005-06-30 | Vereniging Voor Christelijk Wetenschappelijk Onderwijs | Use of riluzole for the treatment of multiple sclerosis |
| WO2003083067A2 (en) * | 2002-03-28 | 2003-10-09 | Brigham And Women's Hospital, Inc. | Histone deacetylase inhibitors for the treatment of multiple sclerosis, amyotrophic lateral sclerosis and alzheimer's disease |
| GB0304636D0 (en) * | 2003-02-28 | 2003-04-02 | Britannia Pharmaceuticals Ltd | Pharmaceutical composition for nasal delivery |
| EP2228054A1 (en) * | 2009-03-13 | 2010-09-15 | ITALFARMACO S.p.A. | Riluzole aqueous suspensions |
| JP2011093849A (ja) * | 2009-10-30 | 2011-05-12 | Kissei Pharmaceutical Co Ltd | トラニラストの易溶性粉末吸入製剤 |
| US9241933B2 (en) * | 2011-03-01 | 2016-01-26 | Pharnext | Compositions for treating amyotrophic lateral sclerosis |
| CN109316480A (zh) * | 2011-07-13 | 2019-02-12 | 赛特凯恩蒂克公司 | 组合als疗法 |
| CA2864008C (en) * | 2012-03-01 | 2020-04-21 | Pharnext | New compositions for treating amyotrophic lateral sclerosis |
-
2015
- 2015-11-17 US US15/100,162 patent/US20180153862A1/en not_active Abandoned
- 2015-11-17 SG SG11201703897SA patent/SG11201703897SA/en unknown
- 2015-11-17 EA EA201791110A patent/EA201791110A1/ru unknown
- 2015-11-17 WO PCT/US2015/061106 patent/WO2016081466A1/en not_active Ceased
- 2015-11-17 BR BR112017010440A patent/BR112017010440A2/pt not_active Application Discontinuation
- 2015-11-17 AU AU2015350142A patent/AU2015350142A1/en not_active Abandoned
- 2015-11-17 CN CN201580073646.5A patent/CN107735077A/zh active Pending
- 2015-11-17 CA CA2967659A patent/CA2967659A1/en not_active Abandoned
- 2015-11-17 MX MX2017006454A patent/MX2017006454A/es unknown
- 2015-11-17 JP JP2017545857A patent/JP2017535612A/ja active Pending
- 2015-11-17 KR KR1020177016605A patent/KR20170137030A/ko not_active Withdrawn
- 2015-11-17 EP EP15821185.4A patent/EP3220890A1/en not_active Withdrawn
-
2017
- 2017-05-15 IL IL252283A patent/IL252283A0/en unknown
- 2017-05-19 PH PH12017500933A patent/PH12017500933A1/en unknown
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