JP2017525337A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2017525337A5 JP2017525337A5 JP2016573588A JP2016573588A JP2017525337A5 JP 2017525337 A5 JP2017525337 A5 JP 2017525337A5 JP 2016573588 A JP2016573588 A JP 2016573588A JP 2016573588 A JP2016573588 A JP 2016573588A JP 2017525337 A5 JP2017525337 A5 JP 2017525337A5
- Authority
- JP
- Japan
- Prior art keywords
- cancer
- bap1
- biomarker
- expression
- ezh2
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462014594P | 2014-06-19 | 2014-06-19 | |
| US62/014,594 | 2014-06-19 | ||
| PCT/US2015/036677 WO2015196064A1 (en) | 2014-06-19 | 2015-06-19 | Biomarkers for response to ezh2 inhibitors |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017525337A JP2017525337A (ja) | 2017-09-07 |
| JP2017525337A5 true JP2017525337A5 (https=) | 2018-07-26 |
| JP6684230B2 JP6684230B2 (ja) | 2020-04-22 |
Family
ID=54936135
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016573588A Expired - Fee Related JP6684230B2 (ja) | 2014-06-19 | 2015-06-19 | Ezh2阻害剤への応答についてのバイオマーカー |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US20170138946A1 (https=) |
| EP (1) | EP3158086B1 (https=) |
| JP (1) | JP6684230B2 (https=) |
| KR (1) | KR20170020463A (https=) |
| CN (1) | CN106795561B (https=) |
| AU (1) | AU2015276899B2 (https=) |
| BR (1) | BR112016029911A2 (https=) |
| CA (1) | CA2952285A1 (https=) |
| EA (1) | EA036889B1 (https=) |
| ES (1) | ES2870096T3 (https=) |
| IL (1) | IL249443B (https=) |
| MX (1) | MX384423B (https=) |
| SG (2) | SG10202007972SA (https=) |
| WO (1) | WO2015196064A1 (https=) |
| ZA (1) | ZA201608555B (https=) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2887243C (en) | 2012-10-15 | 2024-04-09 | Epizyme, Inc. | Methods of treating cancer |
| KR20180042356A (ko) | 2015-08-24 | 2018-04-25 | 에피자임, 인코포레이티드 | 암 치료 방법 |
| TW201718598A (zh) | 2015-08-27 | 2017-06-01 | 美國禮來大藥廠 | Ezh2抑制劑 |
| US12442042B2 (en) | 2016-02-16 | 2025-10-14 | Agency For Science, Technology And Research | Epigenomic profiling reveals the somatic promoter landscape of primary gastric adenocarcinoma |
| GB201615842D0 (en) * | 2016-09-16 | 2016-11-02 | Ucl Business Plc | Cell death biomarker |
| CN106963765B (zh) * | 2017-03-28 | 2020-04-07 | 上海交通大学医学院附属第九人民医院 | Ezh2抑制剂化合物在制备治疗眼部黑色素瘤的药物中的应用 |
| EP3976044A4 (en) * | 2019-06-03 | 2024-08-07 | Icahn School of Medicine at Mount Sinai | Compounds and methods for inhibiting cancers via rest inhibition |
| GB201919219D0 (en) | 2019-12-23 | 2020-02-05 | Otsuka Pharma Co Ltd | Cancer biomarkers |
| CN118161615B (zh) * | 2024-03-19 | 2025-08-12 | 山东大学齐鲁医院 | Phf20抑制剂在制备抗皮肤癌药物中的应用 |
Family Cites Families (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US548257A (en) | 1895-10-22 | Hay rake and loader | ||
| US5322770A (en) | 1989-12-22 | 1994-06-21 | Hoffman-Laroche Inc. | Reverse transcription with thermostable DNA polymerases - high temperature reverse transcription |
| EP0834575B1 (en) | 1990-12-06 | 2001-11-28 | Affymetrix, Inc. (a Delaware Corporation) | Identification of nucleic acids in samples |
| US6379897B1 (en) | 2000-11-09 | 2002-04-30 | Nanogen, Inc. | Methods for gene expression monitoring on electronic microarrays |
| US6465611B1 (en) | 1997-02-25 | 2002-10-15 | Corixa Corporation | Compounds for immunotherapy of prostate cancer and methods for their use |
| US5932422A (en) * | 1997-11-14 | 1999-08-03 | Millennium Pharmaceuticals, Inc. | Modulation of drug resistance via ubiquitin carboxy-terminal hydrolase |
| US6218114B1 (en) | 1998-03-27 | 2001-04-17 | Academia Sinica | Methods for detecting differentially expressed genes |
| US6004755A (en) | 1998-04-07 | 1999-12-21 | Incyte Pharmaceuticals, Inc. | Quantitative microarray hybridizaton assays |
| US6218122B1 (en) | 1998-06-19 | 2001-04-17 | Rosetta Inpharmatics, Inc. | Methods of monitoring disease states and therapies using gene expression profiles |
| US6406921B1 (en) | 1998-07-14 | 2002-06-18 | Zyomyx, Incorporated | Protein arrays for high-throughput screening |
| US6271002B1 (en) | 1999-10-04 | 2001-08-07 | Rosetta Inpharmatics, Inc. | RNA amplification method |
| US7429466B2 (en) | 2000-01-24 | 2008-09-30 | Hypromatrix, Inc | Methods and arrays for detecting biological molecules |
| CA2398107C (en) | 2000-01-28 | 2013-11-19 | Althea Technologies, Inc. | Methods for analysis of gene expression |
| CN1463291A (zh) | 2001-04-19 | 2003-12-24 | 赛弗根生物系统股份有限公司 | 用质谱法和亲和标记物鉴定生物分子的特性 |
| WO2003070887A2 (en) | 2002-02-20 | 2003-08-28 | Sirna Therapeutics, Inc. | RNA INTERFERENCE MEDIATED INHIBITION OF POLYCOMB GROUP PROTEIN EZH2 GENE EXPRESSION USING SHORT INTERFERING NUCLEIC ACID (siNA) |
| EP1390497A2 (en) | 2001-05-25 | 2004-02-25 | Genset | Human cdnas and proteins and uses thereof |
| US7112408B2 (en) | 2001-06-08 | 2006-09-26 | The Brigham And Women's Hospital, Inc. | Detection of ovarian cancer based upon alpha-haptoglobin levels |
| US20030013208A1 (en) | 2001-07-13 | 2003-01-16 | Milagen, Inc. | Information enhanced antibody arrays |
| WO2003017177A2 (en) | 2001-08-13 | 2003-02-27 | Beyong Genomics, Inc. | Method and system for profiling biological systems |
| US20030215858A1 (en) | 2002-04-08 | 2003-11-20 | Baylor College Of Medicine | Enhanced gene expression system |
| WO2003091735A1 (en) | 2002-04-23 | 2003-11-06 | Millipore Corporation | Sample preparation of biological fluids for proteomic applications |
| DK2500439T4 (da) | 2005-06-20 | 2017-11-13 | Advanced Cell Diagnostics Inc | Kits og produkter til detektering af nukleinsyrer i individuelle celler og til identifikation af sjældne celler fra store heterogene cellepopulationer |
| US20110251216A1 (en) | 2010-02-19 | 2011-10-13 | The Regents Of The University Of Michigan | Compositions and methods for inhibiting ezh2 |
| BR112013005806B1 (pt) | 2010-09-10 | 2022-05-10 | Epizyme, Inc | Métodos para detectar se um indivíduo é um candidato para o tratamento com ou responsivo a um inibidor de ezh2 e usos terapêuticos do dito inibidor de ezh2 |
| US9175331B2 (en) | 2010-09-10 | 2015-11-03 | Epizyme, Inc. | Inhibitors of human EZH2, and methods of use thereof |
| WO2013106002A1 (en) * | 2011-02-16 | 2013-07-18 | Memorial Sloan-Kettering Cancer Center | Bap1 mutational analysis in determining susceptibility to, prognosis of, and treatment of melanocytic neoplasia |
| WO2012144220A1 (en) * | 2011-04-22 | 2012-10-26 | Oncotherapy Science, Inc. | Ezh2 as target gene for cancer therapy and diagnosis |
| CA2850570A1 (en) * | 2011-09-30 | 2013-04-04 | Glaxosmithkline Llc | Methods of treating cancer |
| RU2704445C2 (ru) | 2012-03-12 | 2019-10-28 | Эпизайм, Инк. | Ингибиторы ezh2 человека и способы их применения |
| CA2887243C (en) | 2012-10-15 | 2024-04-09 | Epizyme, Inc. | Methods of treating cancer |
-
2015
- 2015-06-19 EP EP15809484.7A patent/EP3158086B1/en active Active
- 2015-06-19 CN CN201580044280.9A patent/CN106795561B/zh not_active Expired - Fee Related
- 2015-06-19 MX MX2016017097A patent/MX384423B/es unknown
- 2015-06-19 AU AU2015276899A patent/AU2015276899B2/en not_active Ceased
- 2015-06-19 JP JP2016573588A patent/JP6684230B2/ja not_active Expired - Fee Related
- 2015-06-19 BR BR112016029911A patent/BR112016029911A2/pt not_active Application Discontinuation
- 2015-06-19 ES ES15809484T patent/ES2870096T3/es active Active
- 2015-06-19 SG SG10202007972SA patent/SG10202007972SA/en unknown
- 2015-06-19 WO PCT/US2015/036677 patent/WO2015196064A1/en not_active Ceased
- 2015-06-19 SG SG11201610610YA patent/SG11201610610YA/en unknown
- 2015-06-19 EA EA201692497A patent/EA036889B1/ru unknown
- 2015-06-19 KR KR1020177001353A patent/KR20170020463A/ko not_active Abandoned
- 2015-06-19 CA CA2952285A patent/CA2952285A1/en not_active Abandoned
-
2016
- 2016-12-07 IL IL249443A patent/IL249443B/en unknown
- 2016-12-12 ZA ZA2016/08555A patent/ZA201608555B/en unknown
- 2016-12-15 US US15/380,807 patent/US20170138946A1/en not_active Abandoned
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2017525337A5 (https=) | ||
| Reece et al. | The use of circulating tumor DNA to monitor and predict response to treatment in colorectal cancer | |
| Sun et al. | MCM2 in human cancer: functions, mechanisms, and clinical significance | |
| Yang et al. | Expression of miR-149-3p inhibits proliferation, migration, and invasion of bladder cancer by targeting S100A4 | |
| Chen et al. | Down-regulation of long non-coding RNA FOXD3 antisense RNA 1 (FOXD3-AS1) inhibits cell proliferation, migration, and invasion in malignant glioma cells | |
| Jin et al. | The PD-1, PD-L1 expression and CD3+ T cell infiltration in relation to outcome in advanced gastric signet-ring cell carcinoma, representing a potential biomarker for immunotherapy | |
| Tang et al. | LncRNA SLCO4A1-AS1 predicts poor prognosis and promotes proliferation and metastasis via the EGFR/MAPK pathway in colorectal cancer | |
| Zhang et al. | Overexpression of HSPA2 is correlated with poor prognosis in esophageal squamous cell carcinoma | |
| Li et al. | Long noncoding RNA MALAT1 promotes cell proliferation through suppressing miR-205 and promoting SMAD4 expression in osteosarcoma | |
| Xie et al. | Correlations of PD-L1 gene polymorphisms with susceptibility and prognosis in hepatocellular carcinoma in a Chinese Han population | |
| WO2012153187A4 (en) | Markers for cancer prognosis and therapy and methods of use | |
| KR102585110B1 (ko) | 암 예후의 판정 | |
| JP2017516458A5 (https=) | ||
| Wu et al. | Long noncoding RNA HOTTIP expression predicts tumor recurrence in hepatocellular carcinoma patients following liver transplantation | |
| Seisen et al. | A comprehensive review of genomic landscape, biomarkers and treatment sequencing in castration-resistant prostate cancer | |
| Gharib et al. | Investigating the diagnostic performance of HOTTIP, PVT1, and UCA1 long noncoding RNAs as a predictive panel for the screening of colorectal cancer patients with lymph node metastasis | |
| Li et al. | Plasma miRNA-506 as a prognostic biomarker for esophageal squamous cell carcinoma | |
| Pavlidou et al. | Survivin isoforms and clinicopathological characteristics in colorectal adenocarcinomas using real-time qPCR | |
| Jing et al. | Prognostic and diagnostic significance of SDPR-Cavin-2 in hepatocellular carcinoma | |
| Sudoyo et al. | Increased CD8 tumor infiltrating lymphocytes in colorectal cancer microenvironment supports an adaptive immune resistance mechanism of PD-L1 expression | |
| Song et al. | Low DAPK1 expression correlates with poor prognosis and sunitinib resistance in clear cell renal cell carcinoma | |
| Wang et al. | MicroRNA‐384 inhibits the progression of papillary thyroid cancer by targeting PRKACB | |
| Jing et al. | Plasma miR-185 is decreased in patients with esophageal squamous cell carcinoma and might suppress tumor migration and invasion by targeting RAGE | |
| Cui et al. | Role of VEGFA gene polymorphisms in colorectal cancer patients who treated with bevacizumab | |
| Yang et al. | Identification of a functional polymorphism within the 3′-untranslated region of denticleless E3 ubiquitin protein ligase homolog associated with survival in acral melanoma |