JP2017520862A - 水溶性膜タンパク質ならびにその調製および使用方法 - Google Patents

水溶性膜タンパク質ならびにその調製および使用方法 Download PDF

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JP2017520862A
JP2017520862A JP2017502928A JP2017502928A JP2017520862A JP 2017520862 A JP2017520862 A JP 2017520862A JP 2017502928 A JP2017502928 A JP 2017502928A JP 2017502928 A JP2017502928 A JP 2017502928A JP 2017520862 A JP2017520862 A JP 2017520862A
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seq
protein
transmembrane
amino acid
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JP2017520862A5 (enExample
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チャン，シュウガン
タオ，フェイ
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Massachusetts Institute of Technology
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Massachusetts Institute of Technology
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/72—Receptors; Cell surface antigens; Cell surface determinants for hormones
    • C07K14/723—G protein coupled receptor, e.g. TSHR-thyrotropin-receptor, LH/hCG receptor, FSH receptor
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B15/00—ICT specially adapted for analysing two-dimensional or three-dimensional molecular structures, e.g. structural or functional relations or structure alignment
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B5/00—ICT specially adapted for modelling or simulations in systems biology, e.g. gene-regulatory networks, protein interaction networks or metabolic networks
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16C—COMPUTATIONAL CHEMISTRY; CHEMOINFORMATICS; COMPUTATIONAL MATERIALS SCIENCE
    • G16C20/00—Chemoinformatics, i.e. ICT specially adapted for the handling of physicochemical or structural data of chemical particles, elements, compounds or mixtures
    • G16C20/50—Molecular design, e.g. of drugs

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Physics & Mathematics (AREA)
  • General Health & Medical Sciences (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Biophysics (AREA)
  • Organic Chemistry (AREA)
  • Theoretical Computer Science (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Evolutionary Biology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Medical Informatics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Biochemistry (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Cell Biology (AREA)
  • Genetics & Genomics (AREA)
  • Endocrinology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Physiology (AREA)
  • Computing Systems (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
JP2017502928A 2014-03-27 2015-03-26 水溶性膜タンパク質ならびにその調製および使用方法 Pending JP2017520862A (ja)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US201461971388P 2014-03-27 2014-03-27
US61/971,388 2014-03-27
US201461993783P 2014-05-15 2014-05-15
US61/993,783 2014-05-15
US201562117550P 2015-02-18 2015-02-18
US62/117,550 2015-02-18
PCT/US2015/022780 WO2015148820A1 (en) 2014-03-27 2015-03-26 Water-soluble membrane proteins and methods for the preparation and use thereof

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JP2020070346A Division JP2020119589A (ja) 2014-03-27 2020-04-09 水溶性膜タンパク質ならびにその調製および使用方法

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JP2017520862A true JP2017520862A (ja) 2017-07-27
JP2017520862A5 JP2017520862A5 (enExample) 2018-05-17

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JP2017502928A Pending JP2017520862A (ja) 2014-03-27 2015-03-26 水溶性膜タンパク質ならびにその調製および使用方法
JP2020070346A Pending JP2020119589A (ja) 2014-03-27 2020-04-09 水溶性膜タンパク質ならびにその調製および使用方法

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US (2) US20150370960A1 (enExample)
EP (2) EP3805260A1 (enExample)
JP (2) JP2017520862A (enExample)
AU (2) AU2015237137A1 (enExample)
CA (1) CA2978076A1 (enExample)
SG (1) SG11201607980UA (enExample)
WO (1) WO2015148820A1 (enExample)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SG10201701547VA (en) 2011-02-23 2017-03-30 Massachusetts Inst Technology Water soluble membrane proteins and methods for the preparation and use thereof
HK1218858A1 (zh) 2013-03-14 2017-03-17 麻省理工学院 用於长时间持续释放人类抗体的多层可注射自组装肽脚手架水凝胶
WO2015149085A2 (en) * 2014-03-27 2015-10-01 Massachusetts Institute Of Technology Warer-soluble trans-membrane proteins and methods for the preparation and use thereof
US10373702B2 (en) 2014-03-27 2019-08-06 Massachusetts Institute Of Technology Water-soluble trans-membrane proteins and methods for the preparation and use thereof
US11293923B2 (en) 2017-09-01 2022-04-05 Massachusetts Institute Of Technology S-layer protein 2D lattice coupled detergent-free GPCR bioelectronic interfaces, devices, and methods for the use thereof
CN108250290B (zh) * 2018-02-23 2024-03-12 上海捌加壹医药科技有限公司 Ccr4的n端重组蛋白及其用途
US11401320B2 (en) 2020-03-31 2022-08-02 Massachusetts Institute Of Technology QTY FC fusion receptor proteins
TW202216771A (zh) * 2020-06-26 2022-05-01 德商拜耳廠股份有限公司 用於治療應用之ccr8抗體

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040215400A1 (en) * 2003-01-21 2004-10-28 The Trustees Of The University Of Pennsylvania Computational design of a water-soluble analog of a protein, such as phospholamban and potassium channel KcsA
JP2010165216A (ja) * 2009-01-16 2010-07-29 National Institute Of Advanced Industrial Science & Technology 立体構造データ帰属方法、立体構造データ帰属プログラム及び立体構造データ帰属装置
JP2011133962A (ja) * 2009-12-22 2011-07-07 National Institute Of Advanced Industrial Science & Technology 可溶性予測装置および可溶性予測方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007089899A2 (en) * 2006-02-01 2007-08-09 Oklahoma Medical Research Foundation Water-soluble (g protein)-coupled receptor protein
SG10201701547VA (en) * 2011-02-23 2017-03-30 Massachusetts Inst Technology Water soluble membrane proteins and methods for the preparation and use thereof
US20130273585A1 (en) * 2012-04-11 2013-10-17 Gangagen, Inc. Soluble cytoplasmic expression of heterologous proteins in escherichia coli
WO2014176544A1 (en) * 2013-04-25 2014-10-30 The Trustees Of The University Of Pennsylvania Water soluble g-protein coupled receptor

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040215400A1 (en) * 2003-01-21 2004-10-28 The Trustees Of The University Of Pennsylvania Computational design of a water-soluble analog of a protein, such as phospholamban and potassium channel KcsA
JP2010165216A (ja) * 2009-01-16 2010-07-29 National Institute Of Advanced Industrial Science & Technology 立体構造データ帰属方法、立体構造データ帰属プログラム及び立体構造データ帰属装置
JP2011133962A (ja) * 2009-12-22 2011-07-07 National Institute Of Advanced Industrial Science & Technology 可溶性予測装置および可溶性予測方法

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AU2019232778A1 (en) 2019-10-03
US20170344699A1 (en) 2017-11-30
EP3122767A2 (en) 2017-02-01
AU2015237137A1 (en) 2016-10-27
EP3122767B1 (en) 2020-07-08
JP2020119589A (ja) 2020-08-06
SG11201607980UA (en) 2016-10-28
WO2015148820A1 (en) 2015-10-01
AU2019232778B2 (en) 2021-09-09
US20150370960A1 (en) 2015-12-24
CA2978076A1 (en) 2015-10-01
EP3805260A1 (en) 2021-04-14

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