JP2017520523A - Active compound combinations - Google Patents

Abstract

The present invention relates to (A) 2- {3- [2- (1-{[3,5-bis (difluoromethyl) -1H-pyrazol-1-yl] acetyl} piperidin-4-yl) -1,3. -Thiazol-4-yl] -4,5-dihydro-1,2-oxazol-5-yl} -3-chlorophenylmethanesulfonate, (B) fosetyl-aluminum and (C) 2,6-dimethyl-1H, 5H Active compound combinations including [1,4] dithino [2,3-c: 5,6-c ′] dipyrrole-1,3,5,7 (2H, 6H) -tetron, propineb or holpet, in particular The present invention relates to a fungicide composition. Furthermore, the present invention relates to a method for the therapeutic or prophylactic control of plant or crop phytopathogenic fungi, the use of the combination according to the invention for treating seeds, a method for protecting seeds and, inter alia, treated. Related to seeds.

Description

  The present invention relates to (A) 2- {3- [2- (1-{[3,5-bis (difluoromethyl) -1H-pyrazol-1-yl] acetyl} piperidin-4-yl) -1,3. -Thiazol-4-yl] -4,5-dihydro-1,2-oxazol-5-yl} -3-chlorophenylmethanesulfonate, (B) fosetyl-aluminum [aluminum tris (ethylphosphonate), CAS No. 39148-24-8 (known from FR-A-2254276)] and (C) 2,6-dimethyl-1H, 5H- [1,4] dithino [2,3-c: 5,6-c ′] dipyrrole -1,3,5,7 (2H, 6H) -tetron [CAS No. 16114-35-5, US 3364229 and WO 2010/043319], propineb [[[(1-methyl-1,2-ethanediyl) bis [carbamodithioate]] (2-)] zinc homopolymer, CAS No. 12071-83-9 (known from BE 611960)] or holpet [N- (trichloromethylthio) phthalimide, CAS No. 133-07-3, known from US 2553770], in particular fungicidal compositions.

  Furthermore, the present invention relates to a method for the therapeutic or prophylactic control of plant or crop phytopathogenic fungi, the use of the combination according to the invention for treating seeds, a method for protecting seeds and, inter alia, treated. Related to seeds.

  Compound 2- {3- [2- (1-{[3,5-bis (difluoromethyl) -1H-pyrazol-1-yl] acetyl} piperidin-4-yl) -1,3-thiazol-4-yl It is already known that 4,5-dihydro-1,2-oxazol-5-yl} -3-chlorophenylmethanesulfonate has bactericidal properties (WO 2012/025557). However, the activity spectrum of this substance focuses on oomycete disease.

  Furthermore, 2- {3- [2- (1-{[3,5-bis (difluoromethyl) -1H-pyrazol-1-yl] acetyl} piperidin-4-yl) -1,3-thiazol-4- Yl] -4,5-dihydro-1,2-oxazol-5-yl} -3-chlorophenylmethanesulfonate in combination with another fungicide synergistic for controlling phytopathogenic fungi in plants or crops It is also known that combinations can be obtained (WO 2013/127704). However, the activity spectrum of these mixtures focuses on oomycete disease.

  In addition, phosphonic acids and derivatives (phosphonates) such as phosphonate ethyl hydrogen phosphonate and its derivatives with the generic name “fosetyl-aluminum” are used to control phytopathogenic fungi of plants or crops It is also known that it can be used (Pesticide Manual, 14th. Edition (2006); “Modern Agrochemicals”, Vol. 4, No. 3, June 2005; FR-A-2254276). However, the activity of these substances at low application rates is not always sufficient.

  The compound 2,6-dimethyl-1H, 5H- [1,4] dithino [2,3-c: 5,6-c ′] dipyrrole-1,3,5,7 (2H, 6H) -tetron is also a plant and It is also known to be suitable for controlling phytopathogenic fungi in crops (WO 2010/043319). However, the activity of this substance at low application rates is not always sufficient.

  The compound propineb is also known to be suitable for controlling plant and crop phytopathogenic fungi (BE 611960). However, the activity of this substance at low application rates is not always sufficient.

  It is also known that compound holpets are also suitable for controlling phytopathogenic fungi in plants and crops (US 2553770). However, the activity of this substance at low application rates is not always sufficient.

French Patent Application Publication No. 2254276 U.S. Pat. No. 3,364,229 International Patent Application Publication No. 2010/043319 BE 611960 US Pat. No. 2,553,770 International Patent Application Publication No. 2012/025557 International Patent Application Publication No. 2013/127704

Pesticide Manual, 14th. Edition (2006) “Modern Agrochemicals”, Vol. 4, no. 3, June 2005

  Furthermore, the environmental and economic requirements imposed on today's disinfectants, such as the spectrum of action, toxicity, selectivity, application rate, residue formation and desirable preparation capacity, are continuously increasing. In addition, there may also be problems associated with developing resistance to known compounds, for example, so that the novel has at least advantages over their equivalents in some areas Developing a disinfectant is a constant task.

  The present invention provides active compound combinations that achieve at least the above objectives in some aspects.

Surprisingly,
(A) 2- {3- [2- (1-{[3,5-bis (difluoromethyl) -1H-pyrazol-1-yl] acetyl} piperidin-4-yl) -1,3-thiazol-4 -Yl] -4,5-dihydro-1,2-oxazol-5-yl} -3-chlorophenylmethanesulfonate; and
(B) fosetyl-aluminum; and
(C) propineb, holpet, or 2,6-dimethyl-1H, 5H- [1,4] dithino [2,3-c: 5,6-c ′] dipyrrole-1,3,5,7 (2H , 6H) -Tetron;
In addition to having very good bactericidal properties, the novel active compound combinations containing the addition of action spectra for phytopathogenic fungi and / or microorganisms and / or pests to be controlled It has been found that, among other things, it also achieves a synergistic effect that expands the range of action of compound (A), compound (B) and compound (C) in two ways. First, the application rates of compound (A), compound (B) and compound (C) are reduced while maintaining good effects as well. Secondly, the combination achieves a high degree of control of phytopathogens even when the three individual compounds become almost ineffective at such low application ranges. This on the one hand makes it possible to substantially expand the range of phytopathogens that can be controlled and, on the other hand, to improve the safety in use.

  However, in addition to the actual synergistic effect on the bactericidal activity, the combination according to the invention also has the surprising and advantageous further property which in the broad sense can also be referred to as “synergistic activity”. Examples of such advantageous properties that may be mentioned are: The spectrum of bactericidal and / or insecticidal activity extends to other phytopathogenic fungi and / or microorganisms and / or pests, For example, extending to resistant strains; reducing the application rate of the active ingredient; pesticides using the composition according to the invention even at application rates such that the individual compounds have no effect at all Is well controlled; behavior during formulation or application, eg behavior during grinding, sieving, emulsifying, dissolving or dispersing; increased storage stability; improved light stability Better degradability; improved toxicological or ecotoxicological behavior; useful plant characteristics (including: budding, harvesting) amount, More developed root system, increased tillering, increased plant height, larger leaf blades, fewer dead rooted leaves, stronger tillers, improved leaf green color, less necessary fertilizer, less need Improved seeds, more effective tillering, faster flowering, faster maturation of grains, less lodging, enhanced growth on seedlings, improved vitality of plants and faster germination) Or any other advantage well known to those skilled in the art.

  The combination according to the invention may also provide improved osmoticity for the active compound used. Indeed, these compounds are within the scope of the composition according to the invention, even if some of the fungicide compounds used do not have any osmotic or even osmotic properties. May exhibit such properties.

  Similarly, the combinations according to the invention can improve the persistence of the bactericidal efficacy of the active compounds used.

  Another advantage of the combination according to the invention is based on the fact that enhanced efficacy can be achieved.

In a preferred embodiment, the active compound combinations according to the invention provide one or more of the following properties:
Additive increase in spectrum, synergy, improved yield, more developed root system, greener leaves, increased tillering, increased plant height, larger leaf blades, fewer dead rooted leaves, Stronger tiller, less fertilizer needed, more effective tiller, faster flowering, faster grain maturation, less lodging, enhanced growth on seedlings, improved vitality of plants, faster Germination, improved osmotic transfer, improved persistence of bactericidal efficacy, enhanced achievable efficacy.

  Furthermore, preference is given to the active compound combinations according to the invention providing the following properties: an additive increase of the spectrum.

  Furthermore, preference is given to the active compound combinations according to the invention providing the following properties: synergistic effect.

  Furthermore, it is preferred that the active compound combinations according to the invention provide the following properties: improved yield.

  Furthermore, preference is given to the active compound combination according to the invention providing the following properties: a more developed root system.

  Furthermore, it is preferred that the active compound combinations according to the invention provide the following properties: greener leaves.

  Furthermore, preference is given to the active compound combinations according to the invention providing the following properties: increased tillering.

  Furthermore, preference is given to the active compound combinations according to the invention providing the following properties: increased plant height.

  Furthermore, preference is given to the active compound combination according to the invention providing the following properties: larger leaf blades.

  Furthermore, preference is given to the active compound combination according to the invention providing the following properties: less dead rooted leaves.

  Furthermore, preference is given to the active compound combination according to the invention providing the following properties: a stronger tiller.

  Furthermore, preference is given to the active compound combination according to the invention providing the following properties: less necessary fertilizer.

  Furthermore, preference is given to the active compound combination according to the invention providing the following properties: more effective tillering.

  Furthermore, preference is given to the active compound combination according to the invention providing the following properties: faster flowering.

  Furthermore, preference is given to the active compound combination according to the invention providing the following properties: faster ripening of the kernel.

  Furthermore, preference is given to the active compound combinations according to the invention providing the following properties: less lodging.

  Furthermore, it is preferred that the active compound combinations according to the invention provide the following properties: enhanced growth on the seedlings.

  Furthermore, preference is given to the active compound combination according to the invention providing the following properties: faster germination.

  Furthermore, it is preferred that the active compound combinations according to the invention provide the following properties: improved vitality of the plant.

  Furthermore, preference is given to the active compound combinations according to the invention providing the following properties: improved osmotic migration.

  Furthermore, it is preferred that the active compound combinations according to the invention provide the following properties: improved persistence of bactericidal efficacy.

  Furthermore, preference is given to the active compound combinations according to the invention providing the following properties: enhanced achievable potency.

For the three-component mixture, the weight ratio of active ingredient compounds is selected to provide the desired effect, eg, synergism:
(A) :( B) :( C) is 1: 500: 200 to 1:50:10; preferably 1: 200: 180 to 1: 100: 25.

  (C) is 2,6-dimethyl-1H, 5H- [1,4] dithino [2,3-c: 5,6-c ′] dipyrrole-1,3,5,7 (2H, 6H) -tetron The most preferred weight ratio is from 1: 200: 40 to 1: 150: 30.

  When (C) is propineb, the most preferred weight ratio is from 1: 200: 180 to 1: 150: 150.

  When (C) is a holpet, the most preferred weight ratio is 1: 200: 150 to 1: 150: 100.

  Where compound (A), compound (B) or compound (C) can exist in tautomeric form, such compounds are specific in any case above and below where appropriate. It is understood that the corresponding tautomeric forms are encompassed even when not mentioned.

The compound (A), the compound (B) or the compound (C) having at least one basic center is, for example, an acid addition salt such as a strong inorganic acid [for example, a mineral acid such as perchloric acid, sulfuric acid , nitric acid, nitrous acid, acid addition salts with phosphoric acid or a hydrohalic acid], strong organic carboxylic acids [for example, is either unsubstituted or substituted (e.g., halo-substituted) C ₁ -C ₄ -Alkanecarboxylic acids such as acetic acid, saturated or unsaturated dicarboxylic acids such as oxalic acid, malonic acid, succinic acid, maleic acid, fumaric acid and phthalic acid, hydroxycarboxylic acids such as ascorbic acid, lactic acid, apples acid, tartaric acid and citric acid, or acid addition salts with benzoic acid], or an organic sulfonic acid [for example, is either unsubstituted or substituted (e.g., halo-substituted) C -C 4 _- alkanesulfonic acids or arylsulfonic acids, for example, can form acid addition salts with methanesulfonic acid or p- toluenesulfonic acid]. Compound (A) or compound (B) having at least one acidic group is, for example, a salt with a base, such as a metal salt [for example, an alkali metal salt or an alkaline earth metal salt, such as a sodium salt, Potassium salts or magnesium salts] or salts with ammonia or organic amines [e.g. morpholine, piperidine, pyrrolidine, mono-, di- or tri-lower alkylamines such as ethylamine, diethylamine, triethylamine or dimethyl-propyl- Amine or salts with mono-, di- or tri-hydroxy-lower alkyl amines such as monoethanolamine, diethanolamine or triethanolamine] can be formed. Furthermore, depending on the case, a corresponding internal salt can also be formed. In the context of the present invention, agrochemically advantageous salts are preferred. In view of the close relationship between compound (A), compound (B) or compound (C) in the free form and compound (A), compound (B) or compound (C) in the form of their salts In the above and below, when reference is made to the free compound (A), the free compound (B) or the free compound (C) or a salt thereof, the reference is appropriate and convenient, respectively. It should be understood that the corresponding salts or free compounds (A), free compounds (B) or free compounds (C) are also included. The same applies to tautomers of compound (A), compound (B) or compound (C) and their salts.

  The mixture according to the invention can be the composition itself, but the final composition used is usually an inactive compound of the formula (A) and the compounds (B) and (C). Mixed with a carrier and, if necessary, a surfactant and / or another formulation aid (eg a bulking agent) is added and the mixture is added to an oily formulation, emulsion, flowable formulation, water It is prepared by formulating into a powder, granule wettable powder, powder or granule. The formulation, which is used alone or by adding another inert ingredient, can be used as a pesticide.

  Certain additional components of this final composition will be described later.

  The “composition” comprises combining the compound represented by the formula (A) described above and the compound (B) and the compound (C), and then making the preparation or a dilution thereof. Can be prepared.

  For the sake of clarity, a mixture means a physical combination of a compound of formula (A), a compound (B) and a compound (C), whereas the composition comprises further additives to the mixture. It means a combination in a form suitable for the application of agrochemicals, for example (surfactant, solvent, carrier, pigment, antifoam, thickener and extender) added.

  The invention further relates to a method of controlling harmful microorganisms, wherein the method comprises contacting the composition with the harmful microorganisms or their habitat.

  The invention further relates to a method of treating seed, wherein the method comprises contacting the seed with the composition.

  Finally, the invention also relates to seed treated with the above composition.

  Accordingly, the present invention further comprises a composition for controlling harmful microorganisms (especially harmful fungi and bacteria) comprising an amount of the active ingredient of the present invention that is effective and non-toxic to plants. Also related to things. They are preferably fungicidal compositions containing agriculturally suitable auxiliaries, solvents, carriers, surfactants or extenders.

  In the context of the present invention, “control of harmful microorganisms” means that infection by harmful microorganisms measured as bactericidal efficacy is reduced, preferably treated, compared to untreated plants. 25-50% reduction compared to non-plants (100%), more preferably 40-79% reduction compared to untreated plants (100%), even more preferred Means that infection by harmful microorganisms is completely suppressed (70-100%). The control can be therapeutic, i.e. to treat already infected plants, or can be protective to protect plants that are not yet infected.

  An “effective but non-phytotoxic amount” is sufficient to control a plant fungal disease satisfactorily or to completely eradicate a plant fungal disease. However, at the same time, it means the amount of the composition of the present invention which does not cause symptoms such as serious phytotoxicity. In general, such application rates can be varied within a relatively wide range. It depends on several factors, for example on the fungi to be controlled, the plants, the climatic conditions and the components of the composition of the invention.

Suitable organic solvents include all polar and non-polar organic solvents commonly used for pharmaceutical purposes. Preferably, the solvent is selected from: ketones such as methyl-isobutyl-ketone and cyclohexanone, amides such as dimethylformamide and alkanecarboxylic acid amides such as N, N-dimethyldecane. Amides and N, N-dimethyloctaneamide, as well as cyclic solvents such as N-methyl-pyrrolidone, N-octyl-pyrrolidone, N-dodecyl-pyrrolidone, N-octyl-caprolactam, N-dodecyl-caprolactam and butyrolactone, , strongly polar solvents, e.g., dimethyl sulfoxide, and aromatic hydrocarbons, e.g., xylene, Solvesso ^TM, mineral oil, for example, white spirit, petroleum, alkylbenzenes and spindle oil, furthermore, esters such as propylene Glycol-monomethyl ether acetate, adipic acid dibutyl ester, acetic acid hexyl ester, acetic acid heptyl ester, citric acid tri-n-butyl ester and phthalic acid di-n-butyl ester, and alcohols such as benzyl alcohol and 1-methoxy -2-propanol.

  According to the invention, the carrier is a natural or synthetic organic or inorganic substance that is mixed or combined with the active ingredient in order to improve its applicability, in particular with regard to application to plants or plant parts or seeds. It is. Such carriers, where the carriers can be solid or liquid, are generally inert and should be suitable for use in agriculture.

  Useful solid or liquid carriers include, for example: ammonium salts, and natural rocks such as kaolin, clay, talc, chalk, quartz, attapulgite, montmorillonite or diatomaceous earth, and Synthetic rocks such as finely divided silica, alumina and natural or synthetic silicates, resins, waxes, solid fertilizers, water, alcohols, in particular butanol, organic solvents, mineral and vegetable oils, and derivatives thereof. Mixtures of such carriers can be used as well.

  Suitable solid extenders and carriers include the following: inorganic particles such as carbonates, silicates having an average particle size of 0.005 to 20 μm (preferably 0.02 to 10 μm), Sulfates and oxides such as ammonium sulfate, ammonium phosphate, urea, calcium carbonate, calcium sulfate, magnesium sulfate, magnesium oxide, aluminum oxide, silicon dioxide, so-called particulate silica, silica gel, natural or synthetic silicates and alum Silicates as well as plant products such as flour, wood flour / sawdust and cellulose powder.

  Useful solid carriers for granules include, for example: pulverized and separated natural stones, such as calcite, marble, pumice, leptose, dolomite, and inorganic and organic coarse grinding Synthetic granules made of flour, and further, granules made of organic materials such as sawdust, coconut shell, corn cobs and tobacco petiole.

  Useful liquefied gas extenders or carriers are liquids that are gaseous at standard temperature and pressure, such as aerosol propellants such as halohydrocarbons, butane, propane, nitrogen and carbon dioxide.

  In the above formulations, tackifiers such as carboxymethylcellulose and natural and synthetic polymers in the form of powders or granules or latex such as gum arabic, polyvinyl alcohol and polyvinyl acetate, or natural phospholipids such as Sephaline and lecithin, synthetic phospholipids, and the like can be used. Further additives can be mineral and vegetable oils.

  When the extender used is water, for example, an organic solvent can be used as an auxiliary solvent. Useful liquid solvents are essentially the following: aromatic compounds such as xylene, toluene or alkylnaphthalenes, chlorinated aromatic compounds and chlorinated aliphatic hydrocarbons such as chlorobenzenes, chloroethylene Or dichloromethane, aliphatic hydrocarbons such as cyclohexane or paraffins such as mineral oil fractions, mineral and vegetable oils, alcohols such as butanol or glycol and their ethers and esters, ketones such as acetone, methyl ethyl ketone, Methyl isobutyl ketone or cyclohexanone, strong solvents such as dimethylformamide and dimethyl sulfoxide, and also water.

  The composition of the present invention may additionally contain further components (for example, a surfactant and the like). Useful surfactants are emulsifiers and / or foam formers, dispersants or wetting agents that have ionic or nonionic properties, or mixtures of such surfactants. Examples of these are: polyacrylic acid salts, lignosulfonic acid salts, phenolsulfonic acid or naphthalenesulfonic acid salts, ethylene oxide and fatty alcohol polycondensates or ethylene oxide and fatty acid polycondensates or Polycondensates of ethylene oxide and fatty amines, substituted phenols (preferably alkylphenols or arylphenols), salts of sulfosuccinic acid esters, taurine derivatives (preferably alkyl taurates), phosphate esters or polyethoxylated polyethoxylated alcohols A phosphate ester of a fluorinated phenol, a fatty acid ester of a polyol, and derivatives of the compound containing sulfate anions, sulfonate anions and phosphate anions, such as alkylaryl polyglycol esters Ethers, alkyl sulphonates, alkyl sulphates, aryl sulphonates, protein hydrolyzates, lignosulphite waste liquors and methylcellulose. If one of the active ingredients and / or one of the inert carriers is water insoluble and the application is carried out with water, it is necessary to have a surfactant present. The proportion of surfactant is from 5% to 40% by weight of the composition according to the invention.

Suitable surfactants (adjuvants, emulsifiers, dispersants, protective colloids, wetting agents and adhesives) include all common ionic and nonionic substances such as: ethoxy Nonylphenols, polyalkylene glycol ethers of linear or branched alcohols, reaction products of alkylphenols with ethylene oxide and / or propylene oxide, reaction products of fatty acid amines with ethylene oxide and / or propylene oxide, Aliphatic esters, alkyl sulfonates, alkyl sulfates, alkyl ether sulfates, alkyl ether phosphates, aryl sulfates, ethoxylated aryl alkyl phenols such as tristyryl-phenol-ether Kishireto such, further ethoxylated and Puropoikishi aryl alkylphenols, likewise, sulfated or phosphorylated arylalkylphenols - ethoxy and propoxylate ethers - ethoxylates and sulphated or phosphorylated arylalkylphenols. Further examples are: natural and synthetic water-soluble polymers such as lignosulfonates, gelatin, gum arabic, phospholipids, starch, hydrophobic modified starches and cellulose derivatives, in particular cellulose esters and cellulose ethers, Furthermore, polyvinyl alcohol, polyvinyl acetate, polyvinyl pyrrolidone, polyacrylic acid, polymethacrylic acid, a copolymer of (meth) acrylic acid and (meth) acrylic acid ester, and methacrylic acid neutralized with an alkali metal hydroxide Copolymers of methacrylic acid esters, and further condensates of optionally substituted naphthalene sulfonate and formaldehyde.

  Colorants such as inorganic pigments such as iron oxide, titanium oxide and Prussian blue, and organic dyes such as alizarin dyes, azo dyes and metal phthalocyanine dyes, and micronutrients such as iron salts, Manganese, boron, copper, cobalt, molybdenum, zinc, and the like can be used.

  Antifoaming agents that can be present in the formulation include, for example, silicone emulsions, long chain alcohols, fatty acids and their salts, and further, fluoro-organic substances, and mixtures thereof. it can.

  Examples of thickeners are polysaccharides such as xanthan gum or Veegum, silicates such as attapulgite, bentonite, and particulate silica.

  Where appropriate, other additional components are also present, such as protective colloids, binders, adhesives, thickeners, thixotropic substances, penetrants, stabilizers, sequestering agents, complexing agents, etc. Can be made. In general, the active ingredient can be combined with any solid or liquid additive commonly used for pharmaceutical purposes.

  The mixtures or compositions of the present invention can be used as they are, or, depending on their specific physical and / or chemical properties, their formulation forms or formulations as follows: Use forms prepared from: for example, aerosols, capsule suspensions, cold-fogging concentrates, warm-fogging concentrates, encapsulated granules , Fine granules, seedable flowables, ready-to-use solutions, dustable powders, emulsions, oil-in-water emulsions, water-in-oil emulsions, large granules, fine granules Agent, oil-dispersible powder, oil-miscible flowable agent, oil-miscible liquid agent, gas agent (under pressure), gas generation (Gas generating product), foam agent (foam), paste agent, pesticide powder seed, suspension formulation, suspension formulation, soluble concentrate, suspension formulation, hydration Impregnated with powders, soluble powders, powders and granules, water-soluble and water-dispersible granules and tablets, water-soluble and water-dispersible powders for seed treatment, wettable powders and active ingredients Natural products and synthetic materials, as well as those that are microencapsulated in polymeric materials and those that are microencapsulated in seed coating materials, and also ULV cold- fogging form ulation) and ULV warm-fogging formulation.

  The compositions of the present invention include commercial preparations that must be diluted with water prior to use, as well as formulations that are ready for use and that can be applied to plants or seeds using appropriate equipment. Concentrates are also included. Conventional applications include, for example, diluting with water and then spraying the resulting spray solution, diluting with oil, applying, undiluted directly, seed treatment or granulation For example, soil application.

  The mixtures, compositions and formulations according to the invention are generally 0.05 to 99% by weight, 0.01 to 98% by weight, preferably 0.1 to 95% by weight, more preferably 0.5 to 90%. % By weight of active ingredient, most preferably 10 to 70% by weight of active ingredient. In the case of special applications, for example in the case of special applications to protect timber and wood products formed therefrom, the mixtures, compositions and formulations according to the invention are generally from 0.0001 to 95% by weight, preferably 0.001 to 60% by weight of active ingredient.

  The content of the active ingredient in the application forms prepared from the formulation can vary within wide limits. The concentration of the active ingredient in the application form is generally 0.000001 to 95% by weight, preferably 0.0001 to 2% by weight.

  The above formulations are prepared in a manner known per se, for example by adding the active ingredient to at least one conventional bulking agent, solvent or diluent, adjuvant, emulsifier, dispersant and / or binder or fixing agent, wetting agent, repellent. Liquid agents, if appropriate, desiccants and UV stabilizers, and, where appropriate, dyes and pigments, antifoams, preservatives, inorganic and organic thickeners, adhesives, gibberellins As well as further processing aids and further mixed with water. Depending on the type of formulation to be prepared, further processing steps are required, for example wet milling, dry milling and granulation.

  The mixtures or compositions of the invention can be present by themselves, or in their (commercial) formulations and in the forms of use prepared from such formulations, insecticides, attractants, fertility agents Present as a mixture with other (known) active ingredients such as, bactericides, acaricides, nematicides, fungicides, growth regulators, herbicides, fertilizers, safeners and / or information chemicals Can do.

  The treatment according to the invention of plants and plant parts with the above mixtures or compositions can be carried out according to customary treatment methods, for example by dipping, spraying, spraying, irrigation, vaporization, dusting, fumes, spreading, foaming, application. , Spreading-on, irrigation (drenching), drip irrigation, etc., or the active ingredient or composition is placed around plants, plant parts, habitat or storage space In the case of a propagation material, especially in the case of seeds, further, dry seed treatment, wet seed treatment, slurry treatment, encapsulation, one or more coatings (coat) ) Is also performed by coating. In addition, the mixture or composition can be used by an ultra-low volume method, or the mixture or composition preparation or the active ingredient itself can be injected into the soil. It is.

Plant / Crop Protection The mixture or composition or composition has a strong microbicidal activity and is responsible for harmful microorganisms (eg fungi and bacteria) in crop protection and protection of material materials Can be used to control).

  The present invention further relates to a method for controlling harmful microorganisms, wherein the method comprises subjecting the mixture or composition of the present invention to the phytopathogenic fungi, phytopathogenic bacteria and / or their habitat environment. It is characterized by being applied to.

  Bactericides can be used to control phytopathogenic fungi in crop protection. They include a wide range of phytopathogenic fungi, including soil-borne pathogens, where the phytopathogenic fungi are, in particular, the species Plasmophorophycetes, Onomycetes (synonyms: Omycetes), A class of members of the class of Chyridiomycetes, Zygomycetes, Ascomycetes, Basidiomycetes and Deuteromycetes (synonymous: a member of the characterization of Fungi imperfecti) . Some fungicides exhibit osmotic activity and can be used as foliar fungicides, seed dressing fungicides or soil fungicides in plant protection. Furthermore, they are suitable for combating fungi, in particular fungi that invade timber or plant roots.

  Bacterides are used to protect Pseudomonadaceae, Rhizobaceaceae, Enterobacteriaceae, and Corynebacteriaceae, in the protection of crops. Can be used for.

Non-limiting examples of fungal pathogens that can be treated according to the present invention include the following:
Diseases caused by powdery mildew pathogens, for example: Blumeria species, for example, Blumeria graminis; Podosphaera species, for example, Podosphaera leukotri ); Sphaerotheca species, for example, Sphaerotheca friginea; Uncinula species, for example, Unsinula necator;
Diseases caused by rust pathogens, such as: Gymnosporangium species, for example, Gymnosporium sabinae; Hemileia, for example, Hememirea, · Basutatorikusu (Hemileia vastatrix); Phakopsora spp various (Phakopsora species), for example, Phakopsora pachyrhizi (Phakopsora pachyrhizi), and Phakopsora meibomiae (Phakopsora meibomiae); Puccinia genus various (Puccinia species), for example, Puccinia Rekonjite (Puccinia recon ite), Puccinia Torichishina (P. triticina), Puccinia graminis (P. graminis) or Puccinia Sutoriihorumisu (P. striiformis); Uromisesu genus various (Uromyces species), for example, Uromisesu-Apenjikuratsusu (Uromyces appendiculatus);
Diseases caused by pathogens of the group Oomycetes, such as: Albugo species, such as Albgo candida; Bremia species, such as Bremia・ Plenospora species, such as Peronospora pis, P. brassicae, P. brasicae, P. brasicae, P. plastmoparas (Plasmoparas) species, eg, Plasmopara viticola; various species of Pseudoperonospora species, such as, Various (Pythium specifications), for example, Pythium ultimum;
• Leaf blot disease and leaf wilt disease due to, for example, the following: Alternaria species, such as Alternaria solani; Cercospora or C; species, for example, Cercospora beticola; Cladiosporium species, for example, Cladiosporium cucumorium, Cocriborus colibol (Cochliob olus sativus) (conidia form: Drechslera, synonym: Helminthosporium), Cochliobolus miyabeanus (Cochliobolus miyabeanus); Colletotrichum sp various (Colletotrichum species), for example, Colletotrichum & Rindemutaniumu (Colletotrichum lindemuthanium); Shikurokoniumu genus various (Cycloconium species), For example, Cycloconium oleaginum; Diaporthe species, such as Diaporthe citri; Elsinoe species E.g., Elsinoe fawsettii; gloeosporium species; e.g., gloeosporium laeticor; Cingulata); Guignardia species, for example, Guignardia bidwelli; Leptophaeria species, for example, Tosufaeria-Nodorumu (Leptosphaeria nodorum); Magnaporthe sp various (Magnaporthe species), e.g., Magnaporthe grisea (Magnaporthe grisea); genus Microdochium various (Microdochium species), for example, Microdochium nivale (Microdochium nivale); Mikosufaerera genus various (Mycosphaerella species ), For example, Mycosphaerella graminicola, Mycosphaerella arachidikola (M. arachidicola) and M. fijiensis; Phaeosphaeria species, such as Phaeosphaeria nodorum; Pirenosporae, Pirenophorae c. (Pyrenophora teres), Pyrenophora tritici repentis; Various species of Ramularia species, for example, Ramularia colomia Roraria Rhynchosporium species, for example, Rynchosporium secalis; Septoria species (for example, Septoria apii, p. S. Typhula species, for example, Typhra incarnata; Venturia species, for example, Venturia inequalis;
Root and stem diseases, for example due to: Corticium species, eg Corticium graminearum; Fusarium species, eg Fusarium oxysporum (Fusium oxysporum) Various species of genus Gaeumannomyces, such as Gaeumannomyces graminis; various species of Rhizotonia disease, such as Rhizoctonia sola For example Caused by Sarocldium oryzae; sclerotium disease, which is caused by, for example, Sclerotium oryzae; Tapesia species, for example, Various Thielabiopsis species, for example, Thielabiopsis basica;
Ear and panic disease (including corn cob), eg due to the following: Alternaria species, eg Alternaria spp .; Aspergillus Aspergillus species, for example, Aspergillus flavus; Cladosporium species, for example, Cladosporum clasporoids; Cladosporum clasporoids; For example, Clavipes purpura purea; various species of Fusarium species, for example, Fusarium culmorum; various species of Gibberella species, for example, Gibberella zera, on a genus of Gibberella zeae; Monographella nivalis; Septoria species, such as Septoria nodolum;
Diseases caused by smut fungi, such as for example: Sphacerotheca species, eg Sfaceloteca reiliana; Tiletia sp., Tilletia sp. Tilletia caries, T. controversa; Urocystis species, such as Urocystis occulta; Ustilago, Ustilago, Ustilago species nuda), Ustilago Nuda Torrichi (U. nud) a tritici);
Fruit rot, for example due to: Aspergillus species, such as Aspergillus flavus; Botrytis species, such as B Cinerea); Penicillium species; for example, Penicillium expansum and P. purpurothiorocureus; Orum); Beruchishiriumu genus various (Verticilium species), for example, Beruchishiriumu-Aruboatorumu (Verticilium alboatrum);
-Seed and soilborne decay, seed, soil, rot and dumping-off disease, for example due to: Alternaria species, for example, Alternaria brassicicola; Aphanomyces species, for example, Aphanomyces aphaetices ), For example, due to Ascochita lentis Aspergillus species, for example, Aspergillus flavus; Cladosporium species, for example, Cladosporum herbalum; Caused by various species (Cochliobolus species), for example, Cochliobolus sativus; (conidia form: Drechslera, Bipolaris), synonyms (Colletosprum) caused by Lletotrichum coccodes; caused by Fusarium species, for example, Fusarium culmorum; caused by Gibberella species; Various species of genus (Macrophomina species), for example, Macrophomina phaseolaina; Various species of Monographella species, for example, Various species of Monographella nivariis (Pridium genus; m specifications), for example, caused by Penicillium expansum; various species of Homa, for example, Homa lingham; various species of Homopsis, for example, Phomopsis, Due to Phomopsis sojae; due to Phytophthora species, eg due to Phytophthora actorum; due to Pyrenophores, Pyrenophora species, such as Pyrenophora Various kinds of Pyrichralia ularia species, eg, caused by Pyricularia oryzae; Pythium species, eg, Pythium ultimum; eg, Rhizonia sp. Caused by Rhizoctonia solani; caused by Rhizopus species, for example, Rhizopus oryzae; caused by Rhizopus oryzae, for example, Sclerotium species, Sclerotium, Sclerophyllum Various kinds of Septoria (Se toria species, eg, from Septoria nodorum; Typhula species, eg, from Typhula incarnata; Verticillium, eg, umsp. Due to Verticillium dahliae;
Cancerous cancers, humps and witches' bloom, eg due to
• Wilt disease, eg due to: Monilinia species: For example, Monilinia laxa;
• Leaf blister or leaf curl disease, for example due to: Exobasidium species, eg, Exobasidium vexans (Exobasidium vexans) Taphrina specifications), for example, Taphrina deformans;
Decline disease of woody plant caused by, for example, the following: Esca disease, for example Phaemonella clamidospora, Pheaeocreumium film (Phaeoacremonium aleophilum) and Fomitiporia mediteranea (Eutypa dyeback), which is caused by, for example, Eutpa lata (Eutypa lager); For example, to Ganoderma boninense Caused by Rigidoporus disease, which is caused, for example, by Rigidoporus lignosus;
• Flower and seed diseases, for example due to: Botrytis species, eg Botrytis cinerea;
Diseases of plant tubers, for example due to: Rhizoctonia species, eg Rhizoctonia solani; Helminthsporium species, eg, Helminthosporum species Solani (Helminthosporium solani);
• Club roots, for example due to: Plasmodiophora species, for example Plasmophorora brassicae;
Diseases caused by bacterial pathogens such as, for example: Xanthomonas species, such as Xanthomonas campestris pv. Oryzae (Xanthomonas campestris pv. Oryzae); Pseudomonas species, for example, Pseudomonas syringae pv. Pseudomonas syringae pv.

The following diseases of soybean can preferably be controlled:
• Fungal diseases of leaves, stems, pods and seeds, for example due to:
Alternaria leaf spot (alternaria leaf spot) (Alternaria spec. Atrans tenuissima), anthracnose (Colletotrichum gloeosporoides dematium var. Truncatum), 褐紋 disease (brown spot) (Septoria glycines), purpura (cercospora leaf spot and blight) ( Cercospora kikuchii), Chonephora leaf blight (Choanephora infundiblifera trispoora (Syn.)), Dactuliophora foulatophora foulatophora glycines), downy mildew (Peronospora manshurica), Drechslera blight (drechslera blight) (Drechslera glycini), leaf spot (frogeye leaf spot) (Cercospora sojina), freckles disease (leptosphaerulina leaf spot) (Leptosphaerulina trifolii), Haiboshi Disease (phyllostica leaf spot) (Phylosticta sojaecola), pod and stem blight (Phomopsis sojae), powdery mildew (Microsphaera diffusa fre) yrenochaeta glycines), leaf blight (rhizoctonia aerial, foliage, and web blight) (Rhizoctonia solani), rust (Phakopsora pachyrhizi, Phakopsora meibomiae), sphaceloma disease (Sphaceloma glycines), the stem Fi potassium leaf blight (stemphylium leaf blight ) (Stemphylilium botryosum), Corynespora casicicola;
• Fungal diseases of the roots and stems, for example due to:
Black root rot (Calonectria crotalariae), charcoal rot (Macrophomina phaseolina), Fusarium blight or worthorum, Fudumorium, pod and collar rot Mycotoptodiscus rot rot (mycoletodiscus terrestris), root rot (neocosmospora) (Neocosmospora vasinfecta), black spot (Diaporthe phaseorum), stem rot m canker) (Diaporthe phaseolorum var. caulivora), stem blight (phytophthora rot) (Phytophthora megasperma), deciduous disease (brown stem rot) (Phialophora gregata), rhizome rot (pythium rot) (Pythium aphanidermatum, Pythium irregulare, Pythium debaryanum , Phythium myriotylum, Phythium ultramum), Rhizoctonia root rot, stem decay, and dumping-off (Rhizotonia solanile) stem decay) (Sclerotinia sclerotiorum), sclerotium near Southern Bright's disease (sclerotinia southern blight) (Sclerotinia rolfsii), thielaviopsis root rot (thielaviopsis root rot) (Thielaviopsis basicola).

  The fungicide mixture or fungicide composition of the present invention can be used to control phytopathogenic fungi therapeutically or protectively / preventively. Accordingly, the present invention also relates to therapeutic and protective methods for controlling phytopathogenic fungi using the active ingredients or compositions of the invention, wherein the active ingredients or compositions are seeds Applied to the soil in which the plants or plant parts, fruits or plants are growing.

  Due to the fact that plants are sufficiently resistant to the active ingredients at the concentrations required to control plant diseases, treatment of the above-ground parts of plants, treatment of propagation stocks and seeds, and Soil treatment is possible.

  According to the invention, all plants and plant parts can be treated. Plants include all plants such as desirable and undesired wild plants, cultivars and plant varieties (whether protected or not protected by plant varieties or plant breeder rights) and Means plant population. Cultivars and plant varieties can be produced by conventional breeding and breeding methods (which include, for example, doubling haploids, protoplast fusion, random mutagenesis and directed mutagenesis, molecular It can be a plant obtained by labeling or genetic marking or biotechnological and genetic engineering methods can be used or supplemented). Plant parts mean all parts above and below the plant and all organs, such as branches, leaves, flowers and roots, where, for example, leaves, needles, stems, branches, flowers, Examples include fruit bodies, fruits and seeds, as well as roots, corms and rhizomes. Crop and vegetative and generative propagating materials such as cuttings, corms, rhizomes, carcasses and seeds also belong to the plant part.

  The mixtures or compositions of the invention are suitable for protecting plants and plant organs if the plants are well tolerated, have a desirable degree of toxicity to warm-blooded animals, and are well tolerated by the environment. It is suitable for increasing the yield and is suitable for improving the quality of the harvest. They can preferably be used as crop protection compositions. They are effective against normal sensitive and resistant species and are effective against all developmental stages or some developmental stages.

  Plants that can be treated according to the present invention can include the following main crop plants: corn, soybean, alfalfa, cotton, sunflower, Brassica oil seeds, such as oilseed rape ( Brassica napus (e.g., canola, rape), turnip (Brassica rapa), B. juncea (e.g., (field) mustard) and Abyssinia mustard (Brassica carinata), Alaceaceae sp. Guinea oil palm, coconut), rice, wheat, sugar beet, sugar cane, oat, rye, barley, millet and sorghum, triticale, flax, nuts, grapes and vines, and seeds Various fruits and vegetables belonging to the botanical taxonomic group of, for example, Rosaceae sp. (For example, pomegranates, for example apples and pears, as well as core fruits, for example apricots, cherry, almonds, plums and Peach and berries (for example, strawberries, raspberries, red currants, black currants and gooseberries), Ribesioidae sp., Walnuts (Juglandaceae sp.), Bifoliaceae (Besulaceae) ), Various species of Urushiaceae (Anacardiaceae sp.), Various species of Beechaceae (Fagaceae sp.), Various species of Mulaceae (Moraceae sp.), Various types of Oleaceae (Oleaceae sp.) (For example, olive tree) Various species of Actinoceae (Actinidaceae sp.), Various species of Lauraceae (Lauraceae sp.) (For example, avocado, cinnamon, camphor), Various species of Musaceae (for example, Musaceae sp.) (For example, banana tree and plantation), Various of Rubiaceae sp.) (e.g. coffee), Theaceae sp. (e.g. tea), Aegiriaceae (Sterculaeae sp.), Citrus family (Rutaceae sp.) (e.g. lemon, orange, mandarin and grapefruit) Solanaceae sp. (For example, tomato, potato, mustard, pepper, eggplant, tobacco), Lilyaceae sp. ), Compositiae sp. (E.g. lettuce, Datura thistle and chicory (this includes root chicory, endive or chrysanthemum)), Aceraceae (Umbelliferae sp.) (E.g. Carrots, parsley, celery and celeriac), cucurbitaceae sp. (Eg, cucumber (which includes gherkin), pumpkin, watermelon, gourd and melon), leeks (alliaceae sp.) (Eg. , Leek and onion), cruciferae sp. (Eg white cabbage, red cabbage, broccoli, cauliflower, brussels sprouts, Thai rhinoceros, kohlrabi, radish, horseradish Pepper and Chinese cabbage), various legumes (eg, leguminosae sp.) (Eg, peanut, pea, lentil and common bean (eg, common bean and broad bean)), various species of cepanoceae (eg, chard) Feed beet, spinach, beetroot), various Linaceae sp. (For example, Asa), various kinds of Cannabeacea (for example, timer), Malvaceae (for example, okra, cocoa) Papaveraceae (eg, poppy), Asperagaceae (eg, asparagus); useful plants and ornamental plants in gardens and forests, such as Raw (turf), turf (lawn), grass and stevia (Stevia rebaudiana); and, in any case, those genetically modified these plants were made type. A particularly preferred plant is soybean.

In particular, the mixtures or compositions according to the invention are suitable for controlling the following plant diseases:
Albgo spp. (White rust): ornamental plants, vegetable crops (eg A. candida) and sunflowers (eg A. tragopogonis); Alternaria spp. (Alternaria) spp.) (black spot disease, black spot disease): vegetables, rapeseed (eg, A. brassicola or A. brassicae), sugar beet (eg, A. tenuis), fruit, rice, soybean, and further potato (E.g. A. solani or A. alternata) and tomatoes (e.g. A. solani or A. alternata), and Alternaria spp. (Blackhead disease) in: Wheat; in the following (. Aphanomyces spp) Awanomisesu species:; (. Ascochyta spp) sugar beet and vegetables Ascochyta species in the following: cereals and vegetables, for example, A. in wheat tritici (Ascokita black leaf blight) and A. in barley. Hordei; Bipolaris and Drechlera spp. (Teleomorph: Cochliobolus spp.), for example, spot disease in corn (D. maydis and B. zeicola, for example) B. sorokiniana in cereals and, for example, B. in rice and lawn. oryzae; Blumeria (formerly Erysiphe) graminis (powdery mildew): cereals (eg, wheat or barley); Botryosphaeria spp. "Slack grape vine disease"): vines (eg B. obtusa); Botrytis cinerea (Teleomorph: gray mold, gray scab) in: Fruit trees and berries (especially strawberries), vegetables (especially lettuce, carrot, celeriac and cabbage), rapeseed, flowers, vines, forest crops and wheat (ear mold); Bremia lactucae (Betde's disease) in things: lettuce; Ceratocystis (synonymous. Ophiostoma) spp. (Blue metamorphosis) in: Deciduous trees and conifers, for example C in elm . ulmi (elder blight); Cercospora spp. (Cercospora spot disease): maize (eg C. zeae-maydis), rice, sugar beet (eg C. beticola), sugar cane, vegetables Coffee, soybeans (eg C. sojina or C. kikuchil) and rice; Cladosporium spp .: tomatoes (eg C. fulvum: tomato leaf mold) ) And C. cereals such as C. in wheat. herbarum; Claviceps purpurea (ergot) in: cereals; Cochliobolus (Anamorph: Helminthosporum or Bipolaris) spp. Maize (eg, C. carbonum), cereals (eg, C. sativus, anamorph: B. sorokiniana), and rice (eg, C. miyabeanus, anamorph: H. oryzae); Colletotrichum (Teleomorph: Glomerella) spp. (Anthrax): Cotton (eg, C. gossypii), corn Rokosi (eg, C. gramicola: stem rot and anthrax), small fruit trees, potatoes (eg, C. coccodes), kidney beans (eg, C. lindemuthianum), and soybeans (eg, C. truncatum) Corticium spp. In, for example, C. in rice sasakii (spot blight); Corynespora casicicola (spot disease): soybeans and ornamental plants; Cycloconium spp. Oleaginum; Cylindrocarpon spp. (eg fruit tree cancer or blackfoot disease in vines, Teleomorph: Netria or Neontria spp.): fruit tree, vines ( For example, C. liriodenden; Teleomorph: Neolectria liriodendri, black foot disease) and many types of ornamental trees; Dematophora (Teleomorph) necatrix (root / stalk rot: Diaporthe spp. In, for example, D. in soybean phaseolum (stalk disease); Drechslera (synonymous Helminthosporium, Pyrenophora) spp .: corn, cereals, eg, barley (eg, D. teres, nettle disease), and Wheat (eg, D. tritici-repentis: DTR spot disease), rice, and lawn; Esca disease (grape wilt, apoplexia) in: Due to the following: Formitiporia (synonymous Phellinus punctata), Formitipolia mediterranea (F mediterranea) Phaeomoniera chlamidospora (formerly Phaeocremonium chlamidosporum), Phaeoacremonium alofoum (Phaeoacremonium alophyrum) and / or Bosnia : E. pyri and small fruit trees (E. veneta: anthracnosis), and also vines (E. ampelina: anthracnosis); Entyroma oryzae (leaf black ears) in: Disease): Rice; Epicoccum spp. (Blackhead disease): Wheat; Erysiphe spp. (Powdery mildew) in the following: sugar beet (E. betae), vegetables (eg, E. psi) E.g., cucumber species (e.g., E. cichoracerarum), and cabbage species, e.g., rapeseed (e.g., E. cruciferarum); Eutipa fata (eutipa cancer or wilt, anamorph: Cytosporina) lata, synonymous Libertella blepharis): fruit trees, vines, and many types of ornamental trees; Exerohirum (syn. Helminthosporium) spp. ): Maize (e.g. E. turcumum); Fusarium (Gibberella) spp. (Withering, root and stem rot): various plants such as cereals (e.g. Wheat or barley). Graminearum or F. Culmorum (root rot and leaf spot vitiligo), F. in tomato. oxysporum, F. in soybean. solani and F. in corn. Verticillioides; Gaemannomyces graminis (withering disease): cereals (eg, wheat or barley) and corn; Gibberella spp. in: Cereals (eg, G. zeae) and rice (eg, G. fujikuroi: idiotic seedlings); Glomerella singulata: vines, pomegranates and other plants, and G. in Cotton. gossypii; grain-infecting complex in rice; Guignardia bidwellii (black spot) in: grapevine; Gymnosporangium spp. in the following: Rosaceae And Juniper, e.g. sabinae (pear rust); Helminthsporium spp. (synonyms Drechslera, Teleomorph: Cochliobolus): corn, cereals, and rice; Hemirea spp. (Hemileia spp.) spp.), for example, H. in coffee. vastatrix (coffee leaf rust); Isariopsis clavispora (synonyms Cladosporium vitis): grape tree; Macrophomina phaseoph (ol) Stem rot): soybeans and cotton; Microdochium (synonymous Fusarium) nivele (red snow rot): cereals (eg wheat or barley); • Microsphaera diffusa (powdery mildew): soybean; Monilinia species (Monil) in: nia spp.), for example, M. in fruit and another of the rose family laxa. M.M. fructicola and M. fractica. fructigena (flower and branch blight); Mycosphaerella spp. in: cereals, bananas, berries, peanuts, eg M. in wheat. Graminicola (Anamorph: Septoria tritici, Septoria leaf blight)) or M. in bananas. fijiensis (Sigatoka disease); Peronospora spp. (downy mildew): cabbage (eg P. brassicae), rapeseed (eg P. parasitica), bulbous plant (eg P. destructor) ), Tobacco (P. tabacina), and soybeans (eg, P. manshurica); Phakopsora pachyrhizi and P. meibomiae (soybean rust): Fialophora spp., Such as vines (eg, P. trachephila and P. tetraspora), and Soybean (e.g., P.Gregata: stem disease); Homa, lingam in the following ones (Phoma lingam) (root and stem rot): rapeseed and cabbage, and, P. in sugar beet betae (spot disease); Homopsis spp in
. ): Sunflowers, vines (eg P. viticola: vine split disease), and soybeans (eg stalk carcinoma / steel blight: P. phaseoli, Teleportomorph); (Physoderma maydis) (maize blight): maize; Phytophthora spp. (Withering, root, leaf, stem and fruit rot): various plants, such as pepper and cucumber species ( For example, P. capsici), soybean (eg, P. megasperma, synonymous P. sojae), potato and tomato (eg, P. infestans .; leaf blight and brown rot), and deciduous trees (eg, P. capsicum). ramor m; sudden oak death; Plasmodiophora brassicae (root-knot): cabbage, rapeseed, radish, and another plant; Plasmopara species in (Plasmopara spp.), For example, P. in vines. viticola (grassy mildews, downy mildew) and P. in sunflower. halstedii; Podosphaera spp. (powdery mildew) in the following: Rosaceae, hops, berries and fruit trees, eg P. in apples. Leucotric; Polymyxa spp., such as cereals such as barley and wheat, and P. betae, and viral diseases infectious thereby; Pseudocercosporella herpotriochoides (Eyelophthalmia / Brownosis, Teleomorph: Tapesial yallundae) in cereals. For example, wheat or barley; Pseudoperonospora (downy mildew) in the following: P. in various plants, for example, cucumber species. cubensis, or P. at hops. humili; Pseudopezicula trachephila (keratotic leaf blight, anamorph Phialophora): grape tree; Puccinia spp. (rust) in various: P. in cereals (e.g. wheat, barley or rye). triticina (wheat red rust), p. sriformis (yellow rust), P. hordei (small disease), P. Graminis (black rust) or P. aeruginosa recondita (brown rust of rye), P. in sugarcane. kuehni and, for example, asparagus (eg P. asparagi); Pirenophora tritisi-repentis (Pyrenophora) tritici-repentis (wheat leaf blight) in wheat or barley P . teres (Petular spot disease); Pyricularia spp. in, for example, P. in rice. oryzae (Teleomorph: Magnaporthe grisea. Rice Blast), and P. in turf and cereals. Grisea; Pythium spp. (withering disease): lawn, rice, corn, wheat, cotton, rapeseed, sunflower, sugar beet, vegetables, and other plants (eg, P. ultramum, Or P. aphanidermatum); Ramula spp. In the following, for example R. in barley. Colo-cygni (lamularia leaf and lawn spot / physiological spot disease) and R. in sugar beet. beticola; Rhizoctonia spp. in: cotton, rice, potato, lawn, corn, rapeseed, potato, sugar beet, vegetables, and other various plants such as R. solani (root rot and stem rot), R. in rice. solani (ruby blight) or R. in wheat or barley. cerealis (strain rot); Rhizopus strononifer (soft rot): strawberry, carrot, cabbage, vine, and tomato; Rhynchosporia secalis in (Spot disease): barley, rye, and triticale; Sarocladium oryzae and S. attenuatum (leaf rot): rice; sclerotia species in Sclerotinia spp.) (Stem or white rot): vegetables and field crops such as rapeseed, sunflower (eg Sclerotinia scler) Tiorum), and, soybean (e.g., S.rolfsii); Septoria species in the following ones (Septoria spp):. various plants, such as, S. in Soybean glycines (spot disease), S. in wheat. tritici (Septria leaf blight) and S. cereals in cereals. (Synonyms Stagonosora) nodorum (leaf blight and mildew); Uncinula (synonyms) Erysiphe necator (powdery mildew, anamorph: Oidium tuckeri): grape tree; Setospaeria spp. (Spot disease): maize (eg, S. turcumum, synonymous Helminthosporium turcumum) and lawn; Sphacerotheca spp. : Corn (eg, S. reiliana), millet and sugarcane; Sphaeroteca frigina (Sphae) in: otheca fulignea) (powder disease): cucumber species; Spongosspora subterranea (powder scab): Potato and viral diseases infectious by it; Genus species (Stagonospora spp.): S. cereals in cereals such as wheat. nodorum (leaf blight and blight, teleomorph: Synonyms Phaeosphaeria) nodorum; Syncytium endobioticum in: Potato in the genus spp.), e.g. deformans (leaf-leaf disease) and T. plum in Plum. pruni (plum-packet disease); Thielabiopsis spp. (black root rot) in: tobacco, berries, vegetable crops, soybeans, and cotton, such as T. pneumoniae. basicola (synonyms Chalara elegans); Tilletia spp. (smut or scab): cereals such as T. in wheat. tritici (synonyms T. caries, wheat smut) and T. controversa (atrophic scab); Typhra incarnata (gray snow mold): barley or wheat; Urocystis spp. ), For example, U.S. in rye. occulta (flag smut); Uromyces spp. (rust): vegetable plants, such as kidney beans (eg, U. appendiculatus, synonymous U. phaseol I), and Sugar beet (e.g. U.betae); Ustylago spp. (Bare smut): cereals (e.g. U. nuda and U. avaenae), maize (e.g. maydis: maize smut) and sugar cane; Venturia spp. (decubitus): apple (eg V. inaequalis) and peach; and Verticillium spp. in: (Vert cillium spp) (leaves and shoots wilt). Various plants, such as fruit and appreciation trees, vines, soft fruit, vegetables and field crops, for example, V. strawberries, rape, in potatoes and tomatoes dahliae.

  The mixtures and compositions according to the invention are particularly preferred for controlling the following plant diseases: soybean diseases: Cercospora kikuchii, Elsinoe glycines, diaporte phaseolum var. Sojae (Diaporthe phaseolorum var. Sojae), Septoria Gurishinesu (Septaria glycines), Cercospora Sojina (Cercospora sojina), Phakopsora pachyrhizi (Phakopsora pachyrhizi), Phytophthora Sojae (Phytophthora sojae), Rhizoctonia solani (Rhizoctonia solani), Korinesupora -Corynespora casiicola and Sclerotinia sclerotiorum.

Plant Health The mixtures and compositions according to the invention are suitable for enhancing plant health.

  “Enhancing plant health” means that the mixture or composition of the present invention can be used as a plant growth regulator as defined below, and induces plant fortification / resistance as defined below. Means that it can be used as a compound that can be used to achieve plant physiology as defined below and can be used to increase crop yield as defined below. .

Plant growth regulators In some cases, the mixtures or compositions of the present invention may also be used as herbicides, safeners, growth regulators or agents that improve plant properties at specific concentrations or specific application rates. Or can also be used as a microbicide, for example as a bactericide, antimycotic, bactericidal or virucidal (which also includes compositions against viroids), Alternatively, it can be used as a composition for MLO (mycoplasma-like organisms) and RLO (rickettsia-like organisms). Where appropriate, they can also be used as intermediates or precursors for the synthesis of other active ingredients.

  The active ingredients of the mixtures or compositions of the present invention interfere with plant metabolism and can therefore be used as growth regulators.

  Plant growth regulators can have various effects on plants. The effect of the substance depends essentially on the time of application in relation to the growth stage of the plant, and in addition the amount of active ingredient applied to the plant or their environment and the type of application. In any case, the growth regulator should have certain desirable effects on the crop plants.

  Compounds that modulate plant growth can be used, for example, to inhibit plant vegetative growth. Such inhibition to growth can reduce the frequency of mowing the lawn, for example in the case of lawns, in ornamental gardens, parks and sports facilities, on the roadside, at airports, or in fruit crops. Interesting. Furthermore, it can also inhibit the growth of herbaceous and woody plants on the roadside and in the vicinity of pipelines or overpasses, or very generally in areas where strong plant growth is not desired. is important.

  It is also important to use growth regulators to inhibit the vertical growth of cereals. This reduces or completely eliminates the risk of plants falling before harvesting. In addition, growth regulators in the case of cereals can strengthen the cocoons and counteract lodging. By using growth regulators to shorten and strengthen cocoons, it is possible to apply higher amounts of fertilizer to increase yield without the risk of falling on cereal crops It becomes.

  In many types of crop plants, more vegetation can be planted by inhibiting vegetative growth and therefore higher yields can be achieved based on the surface of the soil. Another advantage of the dwarf plants obtained in this way is that it is easier to grow and harvest crops.

  By inhibiting vegetative growth of plants, yields are also increased because nutrients and assimilation products are used more for flower and fruit formation than for vegetative parts such as plant foliage and roots Can do.

  Often, growth regulators can also be used to promote vegetative growth. This is extremely beneficial when harvesting plant stems and leaves. However, by promoting vegetative growth, more anabolic products are formed and, as a result, more or larger fruits are formed, so reproductive growth can also be promoted.

  In some cases, increased yield can be achieved by manipulating plant metabolism without detectable changes in vegetative growth. In addition, growth regulators can be used to change the composition of the plant, which can result in improved quality of the harvested product. For example, sugar content of sugar beet, sugar cane, and pineapple can be increased, sugar content of citrus fruit can be increased, or protein content of soybean or cereal can be increased. Furthermore, for example, using a growth regulator, it is also possible to suppress deterioration of desirable components (eg, sugar in sugar beet or sugar cane) before or after harvesting. Furthermore, it is possible to positively influence the production or elimination of the second component of the plant. One example is stimulation of latex flow in rubber trees.

  Under the influence of growth regulators, partheno fruit can be formed. Furthermore, it may be possible to influence the sex of the flowers. It is also possible to produce sterile pollen, which is extremely important in breeding and in the production of hybrid seeds.

  By using a growth regulator, the branching of the plant can be controlled. On the one hand, it is possible to promote side branch development by disturbing the apical dominance, which would be highly desirable in combination with growth inhibition, especially in the cultivation of ornamental plants. However, on the other hand, it is also possible to suppress the growth of side branches. This effect is particularly interesting, for example, in tobacco cultivation or in tomato cultivation.

  Under the influence of growth regulators, the amount of plant leaves can be controlled so that plant defoliation is achieved at the desired time. Such litter plays an important role in the mechanical harvesting of cotton, but is also interesting for facilitating harvesting in other crops (eg viticulture). Plant defoliation can also be performed to reduce the transpiration of the plant prior to transplanting the plant.

  Growth regulators can also be used to regulate fruit dehiscence. On the one hand, it is possible to prevent premature cleavage of the fruit. On the other hand, it is also possible to promote fruit dehiscence, or to eliminate flower alternation to achieve the desired population (“decimation”). It can even be promoted. Alternation is understood to mean the characteristics of some fruit species whose yield varies greatly every year for endogenous reasons. Finally, to allow mechanical harvesting or to facilitate manual harvesting, growth regulators can be used to reduce the force required to separate the fruits at harvest time. it can.

  Growth regulators can also be used to speed up or slow down the ripening of the harvest before or after harvesting. This is particularly advantageous as it makes it possible to optimally adapt to market demands. In addition, growth regulators can in some cases improve the color of the fruit. In addition, growth regulators can be used to focus maturity within a specific time period. This establishes the requirements for a complete harvest in a single operation, mechanically or manually, for example in the case of tobacco, tomato or coffee.

  By using growth regulators it is also possible to influence the dormancy of plant seeds or buds, so that plants (such as pineapples or ornamental plants in nurseries), for example, are usually If there is no such thing, it will germinate, germinate or bloom. In areas where there is a risk of frost, it may be desirable to delay the germination or seed germination with growth regulators to avoid damage due to late frost.

  Finally, growth regulators can induce plant resistance to frost, drought or soil high salinity. This makes it possible to cultivate plants in an area that is not normally suitable for plant cultivation.

Resistance induction The active compounds according to the invention can also show a strong strengthening effect in plants. Thus, the active compounds can be used to mobilize plant defenses against attack by unwanted microorganisms.

  In the context of the present invention, substances that enhance plants (inducing resistance) are highly resistant to treated microorganisms when they are subsequently inoculated with undesirable microorganisms. As it appears, it is understood to mean a substance capable of stimulating the plant's defense system.

  The active compounds according to the invention are also suitable for increasing crop yields. Furthermore, they show reduced toxicity and the plants show good tolerance.

  Furthermore, in connection with the present invention, the physiological effects of plants include:

  Temperature tolerance, drought tolerance and recovery after drought stress, water utilization efficiency (this is related to reduced water consumption), inundation tolerance, ozone stress and UV resistance, chemicals (eg heavy metals, salts, Abiotic stress tolerance, including resistance to pesticides (drug mitigation agents, etc.).

  Biological stress resistance, including enhanced fungal resistance and enhanced resistance to nematodes, viruses and bacteria. In the context of the present invention, biological stress tolerance preferably includes enhanced fungal resistance and enhanced resistance to nematodes.

  Enhanced plant vitality, including plant quality and seed vitality, reduced stand failure, improved appearance, enhanced regeneration, improved greening effect and improved photosynthetic efficiency.

  Effects on plant hormones and / or functional enzymes.

  Faster germination, better emergence, more developed root system and / or improved root growth, enhanced tillering ability, more productive tiller, faster flowering, increased plant height and / or Or biomass, shortening of stems, improvement in shoot growth, number of grains / ears, number of ears per square meter, number of stems and / or flowers, increased yield index, larger leaves, Less dead rooting, improved phyllophy, faster ripening / faster fruit ripening, uniform ripening, longer duration of grain filling, better Effects on growth regulators (promoters), including fruit finish, larger fruit / vegetable size, sprouting resistance and reduced lodging.

Increased yield in terms of total biomass per hectare, yield per hectare, grain / fruit weight, seed size and / or hectare weight and increased product quality; Includes:
Improved processability in terms of size distribution (grains, fruits, etc.), uniform ripening, grain moisture, better milling, better alcohol fermentation, better brewing, increased juice yield, Harvestability, digestibility, sedimentation value, falling number, drought stability, storage stability, improved fiber length / strength / uniformity, milk of animals raised in silage and / Or enhancement in meat quality, adaptation to cooking and frying;
In addition, it includes:
Improved quality of fruit / grain, size distribution (grain, fruit, etc.), increased shelf life (storage / shelf-life), firmness / softness, flavor (aroma, texture, etc.), grade (size) , Shape, number of berries, etc.) marketability regarding the number of berries / fruit per fruit, crispness, freshness, wax coverage, frequency of physiological disorders, color, etc .;
In addition, it includes:
Increased desired ingredients such as protein content, fatty acid, oil content, oil quality, amino acid composition, carbohydrate content, acid content (pH), carbohydrate / acid ratio (Brix), polyphenol, starch content Amount, nutritional value, gluten content / index, energy content, flavor, etc .;
And also includes:
Reduced undesirable components such as less mycotoxin, less aflatoxin, geosmin levels, phenolic aroma, laccase, polyphenol oxidase and peroxidase, nitrate content, etc.

Utilization of nutrients, in particular, nitrogen (N) - utilization, phosphorus (P) - utilization, water use efficiency, improved transpiration, respiration and / or CO ₂ assimilation rate, better nodulation, improved Sustainable agriculture, including Ca-metabolism.

  Delayed senescence, which is an improvement in plant physiology (for example, in the longer ripening phase (which results in higher yields), in the longer duration in which the leaves of the plant are green) And thus includes color (greening), moisture content, dryness, and the like. Thus, in the context of the present invention, the specific application according to the invention of the active compound combination can extend the duration of the green leaf area [this delays plant maturation (aging)]. I found out there was. The main advantage for farmers is the longer ripening phase, which results in higher yields. There are also advantages to farmers based on greater flexibility at harvest time.

  Here, the “sedimentation value” is a measure of the quality of the protein and, according to Zeleny (Zeleny number), measures the degree of sedimentation of flour suspended in a lactic acid solution during a standard time interval. Represent. This is accepted as a measure of breadmaking. Swelling of the gluten fraction of the flour in the lactic acid solution affects the sedimentation rate of the flour suspension. Higher gluten content and better gluten quality both slow down settling resulting in higher Zeleny test values. The settling value of flour depends on the protein composition of the wheat and is mainly correlated to the protein content, the firmness of the wheat and the volume of the pot and hearth loaves. The stronger correlation between the Zeleny sedimentation volume and the loaf volume compared to the SDS sedimentation volume may be due to the protein content affecting both the volume and the Zeleny value (Czech J. Food Sci. Vol. 21, No. 3: 91-96, 2000).

  Furthermore, the “falling number” described herein is a measure for the bread-making properties of cereals (especially wheat). The drop number test indicates that bud damage could have occurred. That means that changes to the physical properties in the starch portion of the wheat kernel have already occurred. Here, the falling number device analyzes the viscosity by measuring the resistance of the flour and water paste to the dropping plunger. The time (in seconds) when this occurs is known as the number of drops. The falling number result is recorded as an indicator of the enzyme in the wheat or flour sample and the result is expressed in time (seconds). A high drop number (eg, about 300 seconds) indicates minimal enzyme activity and indicates intact quality wheat or flour. A low drop number (eg, less than 250 seconds) indicates substantial enzyme activity and indicates wheat or flour with damaged shoots.

  The terms "more developed root system" / "improved root growth" include longer root system, deeper root growth, faster root growth, heavier dry weight / biological weight of root, larger volume of root, Indicates a larger root surface area, larger root diameter, higher root stability, more root branching, more root hairs and / or more root tips, and root architecture Can be measured using an appropriate method and an image analysis program (eg, WinRhizo).

  The term “crop water use efficiency” technically refers to the mass of agricultural harvest per unit water consumed, and economically the product produced per unit water consumed. Can be measured, for example, with regard to yield per ha, plant biomass, thousand-kernel mass and number of spikes per square meter.

  The term “nitrogen utilization efficiency” technically refers to the mass of agricultural harvest per unit nitrogen consumed and, economically, the value of product produced per unit nitrogen consumed. , Reflecting ingestion and utilization efficiency (utilization efficiency).

  Greening improvement / improved color and improved photosynthetic efficiency, as well as aging delay, can be measured using well-known techniques such as the HandyPea system (Hansatech). Fv / Fm is a parameter that is widely used to show the maximum quantum efficiency of Photosystem II (PSII). This parameter is widely accepted as a selective indicator of plant photosynthetic capacity in healthy samples that typically achieve a maximum Fv / Fm value of about 0.85. Lower values will be observed when the sample is exposed to certain biological or abiotic stressors that have reduced their ability to photochemical quenching of energy within PSII. Fv / Fm is given as a ratio of variable fluorescence (Fv) divided by maximum fluorescence (Fm). The figure of merit is essentially an indicator of the vitality of the sample. (See, eg, Advanced Technologies in Soil Microbiology, 2007, 11, 319-341; Applied Soil Ecology, 2000, 15, 169-182.).

  Improved greening / improved color and improved photosynthetic efficiency, as well as delayed aging, measured pure photosynthetic rate (Pn), measured chlorophyll content (eg chlorophyll by Ziegler and Ehle pigment extraction methods) Content measurement), photochemical efficiency (Fv / Fm ratio) measurement, shoot growth measurement and final root and / or canopy biomass measurement, tiller density measurement, and root death rate It can also be evaluated by measurement.

  In the context of the present invention, preference is given to improving plant physiological effects selected from the group comprising: enhanced root growth / more developed root system, improved greening, improved Water utilization efficiency (which correlates with reduced water consumption), improved nutrient utilization efficiency (which specifically includes improved nitrogen (N) -utilization efficiency), delayed Aging and increased yield.

  Within the range of increased yields, preference is given to improvements in sedimentation value and fall number and improvements in protein content and carbohydrate content, especially in plants selected from the group of cereals (preferably wheat). is there.

  Preferably, the novel use of the fungicide composition of the present invention comprises (a) preventive and / or therapeutic control (with or without resistance management) of pathogenic fungi and / or nematodes and (b) root It relates to the combined use of at least one of enhanced growth, improved greening, improved water utilization efficiency, delayed aging and increased yield. From the group (b), an increase in root system, water utilization efficiency and N-utilization efficiency is particularly preferred.

Seed Treatment The present invention further includes a method of treating seed.

  The invention further relates to seed that has been treated by one of the methods described in the previous paragraph. The seed according to the invention is used in a method for protecting seed from harmful microorganisms. In these methods, seeds treated with at least one active ingredient according to the invention are used.

  The mixture or composition of the invention is also suitable for treating seed. Most of the damage to crop plants due to harmful organisms is caused by seed infection during storage or after sowing and also during and after germination of the plant. This phase is particularly dangerous. This is because the roots and shoots of growing plants are particularly sensitive, and even minor damage can cause the plants to die. Therefore, there is great interest in protecting seeds and germinating plants with appropriate compositions.

  Control of phytopathogenic fungi by treating plant seeds has been known for a long time and is continually improved. However, seed treatment is accompanied by a series of problems that cannot always be solved satisfactorily. For example, developing a method for protecting seeds and germinating plants that eliminates or at least significantly reduces the additional deployment of crop protection compositions after sowing or plant emergence. desirable. It is also possible to optimize the amount of active ingredient used so that the seed and the germinating plant can be optimally protected from attack by phytopathogenic fungi without damaging the plant itself by the active ingredient used. desirable. In particular, the method of treating seeds should also take into account the endogenous bactericidal properties of the transgenic plant in order to achieve optimal protection of the seed and the germinating plant using a minimum amount of crop protection composition. It is.

  The invention therefore also relates to a method of protecting seeds and germinating plants from attack by phytopathogenic fungi, wherein the method is by treating the seeds with the composition of the invention. The invention further relates to the use of the composition of the invention for treating seed to protect the seed and the germinating plant from phytopathogenic fungi. The invention further relates to seeds treated with the composition of the invention so as to be protected from phytopathogenic fungi.

  Control of phytopathogenic fungi that damage plants after emergence is performed primarily by treating the soil and the aerial parts of the plant with a crop protection composition. As crop protection compositions are concerned with the potential for impacting the environment and human and animal health, efforts are being made to reduce the amount of active ingredient used.

  One of the advantages of the present invention is that by treating the seed with the mixture and composition due to the outstanding osmotic migration properties possessed by the mixtures and compositions of the present invention, Not only is the seed itself protected, but also the plants that emerge after germination are protected. In this way, immediate treatment of the crop at the time of sowing or shortly after sowing can be omitted.

  Furthermore, the mixture or composition of the invention can be combined with, in particular, transgenic seed (in the case of transgenic seed, plants grown from that seed can express proteins that act against pests). It is also considered advantageous that it can be used. By treating such seeds with the mixtures or compositions of the present invention, certain pests can be controlled simply by expressing proteins (eg, insecticidal proteins). Surprisingly, further synergistic effects may be observed in this case. Such synergistic effects further improve the effectiveness of protection against pest attacks.

  The composition according to the invention is suitable for protecting the seeds of all plant varieties used in agriculture, in the greenhouse, in the forest or in horticulture and viticulture. In particular, this includes cereals (eg wheat, barley, rye, triticale, sorghum / millet and oat), corn, cotton, soybeans, rice, potatoes, sunflowers, kidney beans, coffee, beets (eg sugar beet, and Beet for feed), peanuts, rapeseed, poppies, olives, coconuts, cacao, sugar cane, tobacco, vegetables (eg, tomatoes, cucumbers, onions and lettuce), lawn and ornamental plant seeds (see also below) Wanna) It is particularly important to treat cereal grains (eg, wheat, barley, rye, triticale, and oats), corn and rice seeds. Particularly preferred is soybean seed.

  As also described below, the treatment of transgenic seed with the mixtures or compositions of the invention is of particular importance. This relates to plant seeds that contain at least one heterologous gene that allows expression of a polypeptide or protein having insecticidal properties. Heterologous genes in the transgenic seed include, for example, Bacillus species, Rhizobium species, Pseudomonas species, Serratia species, Trichoderma species, Clavibacter species (Clavibacter species) ) Species or from microorganisms of the species Gliocladium. The heterologous gene is preferably derived from a Bacillus sp. Whose gene product is effective against the European maize borer and / or the Western maize rootworm. The heterologous gene is more preferably derived from Bacillus thuringiensis.

  In the context of the present invention, the composition according to the invention is applied to the seed either alone or in a suitable formulation. Preferably, the seed is treated in a sufficiently stable state so that damage does not occur during the treatment. In general, seeds can be treated at any time between harvesting and sowing. Conventionally, seeds that are isolated from the plant and are not accompanied by cobs, shells, petioles, hulls, coats or flesh are used. For example, seed that has been harvested, impurities removed, and dried to a moisture content of less than 15% by weight can be used. Alternatively, seeds that have been treated with water after drying, for example, and then dried again can be used.

  When the seed is treated, the amount of the composition of the present invention and / or the amount of further additives applied to the seed is set so that the germination of the seed is not impaired or the plant produced from the seed is not damaged. General attention should be paid to the choice. This has to be noted, especially in the case of active ingredients that can show toxic effects at a specific application rate.

  The composition of the present invention can be applied directly, i.e., without the inclusion of another component and without dilution. In general, the composition is preferably applied to the seed in the form of a suitable formulation. Suitable formulations and methods for treating seed are known to those skilled in the art and are described, for example, in the following documents: US 4,272,417, US 4,245,432, US 4, 808,430, US 5,876,739, US 2003/0176428 A1, WO 2002/080675, WO 2002/028186.

  Mixtures or compositions that can be used in accordance with the present invention are conventional seed dressing formulations such as solutions, emulsions, suspensions, powders, foams, slurries or other coatings for seeds. It can be converted into a composition and, further, an ULV formulation.

  These formulations are prepared in a known manner with the active ingredient or mixture, customary additives such as customary bulking agents, and also solvents or diluents, colorants, wetting agents, dispersants, emulsifiers, It is prepared by mixing with foaming agent, preservative, second thickening agent, pressure-sensitive adhesive, gibberellins and the like, and further mixing with water.

  Useful colorants that can be present in seed dressing formulations that can be used according to the present invention are all colorants customary for such purposes. Both pigments that are poorly soluble in water and dyes that are soluble in water can be used. Examples thereof include colorants known under the names “Rhodamin B”, “CI Pigment Red 112” and “CI Solvent Red 1”.

  Useful wetting agents that can be present in seed dressing formulations that can be used in accordance with the present invention are all substances that promote wetting that are conventionally used in the formulation of agrochemical active ingredients. Preferably, alkyl naphthalene sulfonates such as diisopropyl naphthalene sulfonate or diisobutyl naphthalene sulfonate are used.

  Useful dispersants and / or emulsifiers that can be present in seed dressing formulations that can be used in accordance with the present invention are nonionic, anionic and cationic commonly used in the formulation of agrochemical active ingredients. All dispersants of sex. Preferably, nonionic or anionic dispersants or mixtures of nonionic or anionic dispersants can be used. Suitable nonionic dispersants include, among others, ethylene oxide / propylene oxide block copolymers, alkylphenol polyglycol ethers and tristyrylphenol polyglycol ethers, and their phosphorylated or sulfated derivatives. Can do. Suitable anionic dispersants are in particular lignosulfonates, polyacrylates and aryl sulfonate / formaldehyde condensates.

  Antifoaming agents that can be present in the seed dressing formulation that can be used according to the present invention are all suds suppressors conventionally used in the formulation of agrochemical active ingredients. Preferably, a silicone antifoam and magnesium stearate can be used.

  Preservatives that can be present in the seed dressing formulation that can be used according to the present invention are all substances that can be used for that purpose in the agrochemical composition. Examples include dichlorophen and benzyl alcohol hemiformal.

  The second thickeners that can be present in the seed dressing formulation that can be used according to the present invention are all substances that can be used for that purpose in the agrochemical composition. Preferable examples include cellulose derivatives, acrylic acid derivatives, xanthan, modified clay, and finely divided silica.

  Adhesives that can be present in seed dressing formulations that can be used according to the present invention are all conventional binders that can be used in seed dressing products. Preferable examples include polyvinyl pyrrolidone, polyvinyl acetate, polyvinyl alcohol, and tyrose.

  The gibberellins that can be present in the seed dressing formulation that can be used according to the invention can preferably be gibberellin A1, gibberellin A3 (= gibberellin acid), gibberellin A4 and gibberellin A7. Particularly preferably, gibberellic acid is used. Gibberellins are known (cf. R. Wegler “Chemie der Pflanzenschutz-und Schadlingsbekampfungsmittel”, Chemistry of the Crop Protection, p. 19).

  Seed dressing formulations that can be used according to the present invention can be used directly to treat a wide range of different seeds, including seeds of transgenic plants, Alternatively, it can be used after previously diluted with water. In this case, an additional synergistic effect may occur in the interaction with the substance formed by expression.

  All conventionally used for seed dressing to treat seed with a seed dressing formulation that can be used according to the present invention or a preparation prepared from that seed dressing formulation by adding water The mixing device is useful. Specifically, the seed dressing procedure involves placing the seeds in a blender, adding the desired amount of seed dressing formulation as it is or after having been previously diluted with water. And mixing everything until the formulation is evenly distributed on the surface of the seed. If appropriate, this is followed by a drying step.

Mycotoxins Furthermore, the treatment according to the invention makes it possible to reduce the content of mycotoxins in the harvest and in foods and feeds made from the harvested crops. Examples of mycotoxins include, but are not limited to, deoxynivalenol (DON), nivalenol, 15-Ac-DON, 3-Ac-DON, T2-toxin, HT2-toxin, Fumonisins, zearalenone, moniliformin, fusarin, diacetoxysylpenol (DAS), bearauricin, enniatin, fusaropliferin, fusarenol, ochratoxins, patulin, ergotroid alkaloids [These can be produced, for example, by the following fungi: inter alia Fusarium spec., For example, Fusarium acuminum (F. cuminatum, F. asiaticum, F. avenaceum, F. crowellense, F. culmorum, F. culmorum, F. umrumum. (Gibberella zeae), F. equiseti, F. fuikoroi, F. musarum, Fusarium oxysporum sp. (F. proliferate), Fusarium poae, Fusarium pou F. pseudograminearum, F. sambucinum, F. sirpium, F. semectum, F. soli (F. soli) F. sporotrichoides, F. langsethiae, F. subglutinans, F. tricinctum, v. Tricinctum, v. Aspergillus Spec. ), For example, Aspergillus flavus (A. flavus), Aspergillus parasiticus (A. paramusicus), Aspergillus novius (A. ochraceus), Aspergillus v. Clavus c. -A. terreus, A. versicolor, Penicillium sp., For example, P. verrucosum, Penicillium penicillium (P. vitricium) P. citrinum), Penicillium expandum (P. expansum), P. claviforme, P. roqueforti, Claviceps sp., For example, C. purpurea, C. purpureis, C. purfifus C. (C. paspali), C. africana, various types of Stachybotrys Species, etc.).

Protection of material substances The mixtures or compositions of the invention can also be used in the protection of material substances to protect industrial materials against attack and destruction by harmful microorganisms (eg fungi) and insects.

  Furthermore, the mixtures or compositions of the invention can also be used as antifouling compositions, alone or in combination with other active ingredients.

  In the context of the present invention, industrial material is understood to mean an inanimate material prepared for use in industry. For example, industrial materials that are intended to protect against microbial denaturation or destruction with the mixtures or compositions of the invention include adhesives, glues, paper, wallpaper and cardboard / paperboard, textiles, carpets, leather, wood, fibers And thin fabrics, paints and plastic products, cooling lubricants, and other materials that can be infected or destroyed by microorganisms. Parts of buildings and manufacturing plants that can be damaged by the growth of microorganisms, such as cooling water circuits, cooling and heating equipment, and ventilation and air conditioning equipment, can also be mentioned as being within the scope of materials to be protected. it can. Industrial materials within the scope of the present invention preferably include adhesives, sizes, paper and cardboard, leather, wood, paints, cooling lubricants and heat transfer fluids, and more preferably wood. Can be mentioned.

  The mixture or composition of the present invention can prevent adverse effects such as decay, decay, discoloration, decolorization or wrinkle generation.

  When treating wood, the compounds / compositions according to the invention can also be used against fungal diseases that will grow on or inside timber. The term “timber” refers to all types of wood, all types of such wood processed for construction, such as solid wood, high density wood, laminated wood and plywood. The method for treating timber according to the invention is mainly carried out by contacting one or more compounds of the invention or the composition of the invention. This includes, for example, direct application, spraying, dipping, pouring, or any other suitable method.

  Furthermore, the compounds of the present invention are used to protect against contact with seawater or freshwater contact (especially hulls, screens, nets, structures, mooring equipment and signal systems). You can also.

  The method of the present invention for controlling harmful fungi can also be used to protect stored goods. Stored goods are understood to mean natural substances of plant or animal origin or processed products of those natural substances whose long-term protection is desired. Stocks of plant origin, such as plants or plant parts, such as stems, leaves, tubers, seeds, fruits, grains, etc. can be protected in freshly harvested state or (preliminary ) It can be protected after being processed by drying, humidification, grinding, grinding, pressing or roasting. Stored items further include both raw wood (eg, building wood, utility poles and fences) or wood in the form of finished products (eg, furniture). Stocks of animal origin are, for example, leather, leather goods, fur and animal hair. The mixture or composition according to the invention can prevent adverse effects such as decay, decay, discoloration, decolorization or wrinkle generation.

  Examples of microorganisms that can degrade or denature industrial materials include bacteria, fungi, yeasts, algae, slime organisms, and the like. The mixtures or compositions of the invention are preferably fungi, in particular molds, fungi that discolor timber and fungi that destroy timber (Ascomycetes, Basidiomycetes, Deuteromycetes) And Zygomycetes), and slime organisms and algae. Microorganisms of the following genera may be mentioned as examples: Alternaria, for example, Alternaria tenuis; Aspergillus, for example Aspergillus niger; Caetomi, C, et al For example, Chaetomium globosum; Coniophora, eg, Coniophora puetana; Lentinus, eg, Lentinus, P. Penicillium glaucum; Polyporus, for example, Polyporus versicolor; Aureobasidium, for example, Aureobasidium pululos (Sclerophoma pitophylla); Trichoderma, for example, Trichoderma viride; Ophiostoma spp., Ceratocystis spp. (Ceratospiris sp.) Cola spp.), Petriella spp., Trichurus spp., Coriolis spp., Gloeophyllum spp., Pleurotus spp. ), Polya spp., Serpula spp. And Tyromyces spp., Cladosporium spp., Paecilomyces spp. Genus species (Mucor spp.), Escherichia, for example, Escherichia coli; Pseudomonas (Pseudomonas), for example, Pseudomonas aeruginosa; Staphylococcus, for example, Staphylococcus aureus, Candida sp. ) And Saccharomyces spp., For example, Saccharomyces cerevisiae.

Antifungal activity Furthermore, the mixtures or compositions according to the invention also have a very good antifungal activity. They have a very broad spectrum of antifungal activity, especially against dermatophytes, as well as yeasts, molds and biphasic fungi [eg Candida species, eg Candida spp. Against C. albicans, C. glabrata], as well as Epidermophyton flocosum, Aspergillus species, such as Aspergillus niger And Aspergillus fumigatus, Trichophyton species, such as Trichophyton mentagrophytes (T. ment It has a very broad spectrum of antifungal activity against agrophytes, various species of Microsporon species, such as M. canis and M. audiwinii. These fungal lists are in no way limited to the included fungal spectrum, but are merely exemplary in nature.

  Thus, the mixtures or compositions of the present invention can be used for both pharmaceutical and non-pharmaceutical applications.

Genetically modified organisms As already mentioned above, all plants and their parts can be treated according to the invention. In a preferred embodiment, wild plant species and plant varieties, or plant species and plant varieties obtained by conventional biological breeding methods such as crossing or protoplast fusion, and parts thereof are treated. In preferred further embodiments, transgenic plants and plant varieties (genetically modified organisms) and parts thereof obtained by genetic engineering methods combined with conventional methods, where appropriate, are treated. The terms “parts” or “parts of plants” or “plant parts” have already been described above. More preferably, plants of plant varieties that are commercially available or used are treated according to the invention. Plant varieties are understood to mean plants with new properties (“traits”) obtained by conventional breeding or mutagenesis or recombinant DNA techniques. These can be varieties, varieties, biotypes or genotypes.

  The treatment method according to the invention can be used in the treatment of genetically modified organisms (GMO) (eg plants or seeds). A genetically modified plant (or transgenic plant) is a plant in which a heterologous gene is stably integrated into the genome. The expression “heterologous gene” is essentially a gene that has been supplied or constructed outside the plant and when introduced into the nuclear genome, chloroplast genome or mitochondrial genome, New or improved in the transformed plant by expressing an interesting protein or polypeptide or by down-regulating or silencing another gene or genes present in the plant Means a gene that imparts agronomical characteristics or other characteristics that have been made (eg, using antisense technology, co-suppression technology, RNA interference (RNAi) technology, or microRNA (miRNA) technology). A heterologous gene located in the genome is also referred to as a transgene. A transgene defined by its specific location in the plant genome is called a transformation or gene transfer event.

  Plants and plant varieties that are preferably treated in accordance with the present invention are all plants that have genetic material that confers a particularly advantageous and beneficial trait to the plant (whether obtained by breeding and / or Including those obtained by biotechnological methods).

  Plants and plant varieties that are also preferably treated according to the present invention are resistant to one or more biological stresses. That is, such plants are good against pests and harmful microorganisms, such as nematodes, insects, mites, phytopathogenic fungi, bacteria, viruses and / or viroids. Show good defense.

  Plants and plant varieties that can be similarly treated according to the present invention are plants that are resistant to one or more abiotic stresses. Examples of abiotic stress conditions include drought, exposure to low temperatures, exposure to heat, osmotic stress, flooding, increased salinity in soil, exposure to more minerals, and exposure to ozone. Examples include exposure, exposure to intense light, limited available nitrogen nutrients, limited available phosphorus nutrients, shade avoidance, and the like.

  Plants and plant varieties that can be similarly treated according to the present invention are plants characterized by increased yield characteristics. Increased yields in such plants are, for example, improved plant physiology, growth and development, such as water utilization efficiency, water retention efficiency, improved nitrogen utilization, enhanced carbon assimilation Can result from improved photosynthesis, increased germination efficiency and accelerated maturation. Yield can also be influenced by improved plant architecture (under stress and non-stress conditions). Such improved plant composition includes, but is not limited to, early blooming, flowering control for hybrid seed production, seedling vitality, plant dimensions, internode number and distance, root growth, seeds Size, fruit size, pod size, number of pods or spikes, number of seeds per pod or spike, seed volume, enhanced seed filling, reduced seed dispersion, reduced cocoon cracking Open and lodging resistance. Additional traits for yield include seed composition, eg, carbohydrate content and composition (eg, cotton), or starch, protein content, oil content and composition, nutritional value, reduction of antinutritive compounds, There are improved processability as well as improved storage stability.

  Plants that can be treated in accordance with the present invention are characterized by hybrid stress, which generally results in increased yield, improved vitality, improved health, and improved resistance to biological and abiotic stresses. It is a hybrid plant that has already exhibited.

  Plants or plant varieties (obtained by plant biotechnology methods such as genetic engineering) that can be treated according to the present invention have been rendered resistant to herbicide-tolerant plants, ie one or more given herbicides. It is a plant. Such plants can be obtained by genetic transformation or can be obtained by selecting plants containing mutations that confer resistance to the herbicide.

  Plants or plant varieties (obtained by plant biotechnology methods such as genetic engineering) that can be similarly treated according to the invention are resistant to attack by insect-resistant transgenic plants, ie specific target insects. Plant. Such plants can be obtained by genetic transformation or can be obtained by selecting plants that contain mutations that confer such insect resistance.

  Plants or plant varieties (obtained by plant biotechnology methods such as genetic engineering) that can be similarly treated according to the present invention are resistant to abiotic stress. Such plants can be obtained by genetic transformation or can be obtained by selecting plants that contain mutations that confer such stress resistance.

  Plants or plant varieties (obtained by plant biotechnology methods such as genetic engineering) that can be similarly treated according to the present invention may be modified amounts, quality and / or storage stability of harvested products, and / or Or it shows the altered characteristics of a particular component of the harvested product.

  Plants or plant varieties that can be similarly treated according to the present invention (those obtainable by plant biotechnology methods such as genetic engineering) are plants with altered fiber properties (eg cotton plants). Such plants can be obtained by genetic transformation or can be obtained by selecting plants that contain mutations that confer such altered fiber properties.

  Plants or plant varieties (that can be obtained by plant biotechnology methods such as genetic engineering) that can be similarly treated according to the present invention are plants having modified oil profile characteristics (eg rapeseed plants or related Brassica plants). ). Such plants can be obtained by genetic transformation or can be obtained by selecting plants that contain mutations that confer such altered oil profile characteristics.

  Plants or plant varieties that can be treated in accordance with the present invention (those obtainable by plant biotechnology methods such as genetic engineering) are plants having modified seed shedding characteristics (eg rapeseed plants or related Brassica plants). ). Such plants can be obtained by genetic transformation or can be obtained by selecting plants that contain mutations that confer such modified seed shedding characteristics. Such plants include plants in which seed shedding has been delayed or reduced (eg, rape plants).

  Plants or plant varieties (obtainable by plant biotechnology methods such as genetic engineering) that can be similarly treated according to the present invention are plants in which the post-translational protein modification pattern has been altered (eg, tobacco plants).

Application rate and time of application When the mixtures or compositions of the invention are used as fungicides, the application rates can be varied within a relatively wide range, depending on the type of application. The application rates of the active ingredient of the present invention are as follows:
When treating plant parts, such as leaves: 0.1-10000 g / ha, preferably 10-1000 g / ha, more preferably 10-800 g / ha, even more preferably 50-300 g / ha (The application rate can be further reduced when applied by irrigation or dripping, especially when using an inert bottom such as rock wool or pearlite);
When treating seeds: 2-200 g per 100 kg seed, preferably 3-150 g per 100 kg seed, more preferably 2.5-25 g per 100 kg seed, even more preferably 2.5-12 per 100 kg seed .5g;
-When processing soil: 0.1-10000 g / ha, Preferably, it is 1-5000 g / ha.

  The above application rates are merely exemplary and are not limiting for the purposes of the present invention.

  The mixtures or compositions of the invention can thus be used to protect plants from attack by the pathogens for a certain period after treatment. The period during which protection is provided is generally from 1 to 28 days, preferably from 1 to 14 days, more preferably from 1 to 10 days, most preferably from 1 to 28 days after the plant has been treated with the mixture or composition. Up to 7 days, or up to 200 days after seed treatment.

  The treatment method according to the invention also provides the use or application of compound (I) and compound (II) and / or compound (III) in a simultaneous or separate or sequential process. When single active ingredients are applied in a sequential manner (ie, at different times), they are applied in sequence within a reasonably short period (eg, hours or days). Preferably, the order in which compound (A) and compound (B) and / or compound (C) are applied is not essential for practicing the present invention.

  The plants listed above can be treated particularly advantageously according to the invention using the mixtures or compositions of the invention. The preferred ranges given above for the active ingredient or composition also apply to the treatment of these plants. Of particular importance is the treatment of plants with the compounds or compositions specifically mentioned herein.

Examples The high bactericidal activity of the active compound combinations according to the invention is evident from the following examples. Although the individual active compounds are inadequate with respect to bactericidal activity, the combination exhibits an activity that is more than just the sum of the activities.

If the bactericidal activity of the active compound combination exceeds the total activity of the active compounds when applied individually, a synergistic effect of the bactericide is always present. The expected activity for a given combination of two active compounds can be calculated as follows (cf. Colby, SR, “Calculating Synthetic Responses and Herbicide Combinations”, Weeds). 1967, 15, 20-22):
X is the potency when active compound A is applied at an application rate of m (ppm) (or g / ha);
Y is the efficacy when active compound B is applied at an application rate of n (ppm) (or g / ha);
Z is the potency when active compound B is applied at an application rate of r (ppm) (or g / ha);
E ₁ is the efficacy when active compound A and active compound B are applied at application rates of m and n (ppm) (or g / ha), respectively; and
E ₂ is the efficacy when active compound A, active compound B and active compound C are applied at application rates of m, n and r (ppm), respectively (or g / ha);
If

And in the case of a ternary mixture,

  The degree of efficacy expressed in “%” is indicated. 0% means efficacy corresponding to that of the control, 100% efficacy means no disease is observed.

  If the actual bactericidal activity exceeds the calculated value, the activity of the combination exceeds the additive one. That is, a synergistic effect exists. In this case, the actually observed efficacy must be greater than the value calculated from the above formula for the expected efficacy (E).

  A further method to demonstrate synergistic effects is that of Tammes (cf. “Isoboles, a graphical representation of synthesis in pesticides” in Neth. J. Plant Path., 1964, 70, 73-80).

  The following examples illustrate the invention. However, the present invention is not limited to these examples.

Example A: In-vivo prophylaxis test for Phytophthora test (tomato) Solvent: 24.5 parts by weight of acetone
24.5 parts by weight of dimethylacetamide emulsifier: 1 part by weight of alkylaryl polyglycol ether In order to prepare a suitable preparation of active compound, 1 part by weight of active compound is mixed with the above amounts of solvent and emulsifier. The resulting concentrate is diluted with water to the desired concentration. To test for prophylactic activity, seedlings are sprayed with the preparation of active compound at the stated application rate. After the spray coating has dried, the plants are inoculated with an aqueous spore suspension of Phytophthora infestans. The plant is then placed in an incubation chamber at about 20 ° C. and 100% relative atmospheric humidity.

The test is evaluated 3 days after the inoculation. 0% means efficacy corresponding to that of the untreated control, 100% efficacy means no disease is observed. The table below clearly shows that the activity observed for the active compound combinations according to the invention is higher than the calculated activity, ie that a synergistic effect exists.

Example B: Venturia Test (Apple) In Vivo Prevention Test Solvent: 24.5 parts by weight of acetone
24.5 parts by weight of dimethylacetamide emulsifier: 1 part by weight of alkylaryl polyglycol ether In order to prepare a suitable preparation of active compound, 1 part by weight of active compound is mixed with the above amounts of solvent and emulsifier. The resulting concentrate is diluted with water to the desired concentration. To test for prophylactic activity, seedlings are sprayed with the preparation of active compound at the stated application rate. After the spray coating has dried, the plants are inoculated with an aqueous conidia suspension of Venturia inequalis, the pathogen of apple scab, and the plants are then inoculated at about 20 ° C. In an incubation room at 100% relative atmospheric humidity for 1 day. The plant is then placed in a greenhouse at about 21 ° C. and a relative atmospheric humidity of about 90%.

The test is evaluated 10 days after the inoculation. 0% means efficacy corresponding to that of the untreated control, 100% efficacy means no disease is observed. The table below clearly shows that the activity observed for the active compound combinations according to the invention is higher than the calculated activity, ie that a synergistic effect exists.

Claims (8)

A synergistic fungicidal active compound combination comprising:
(A) 2- {3- [2- (1-{[3,5-bis (difluoromethyl) -1H-pyrazol-1-yl] acetyl} piperidin-4-yl) -1,3-thiazol-4 -Yl] -4,5-dihydro-1,2-oxazol-5-yl} -3-chlorophenylmethanesulfonate; and
(B) fosetyl-aluminum; and
(C) propineb, holpet, or 2,6-dimethyl-1H, 5H- [1,4] dithino [2,3-c: 5,6-c ′] dipyrrole-1,3,5,7 (2H , 6H) -Tetron;
A combination of said bactericidal active compounds.   Use of the active compound combination according to claim 1 for controlling unwanted phytopathogenic fungi.   Use of the active compound combination according to claim 1 for treating seed.   Use of the active compound combination according to claim 1 for the treatment of transgenic plants.   Use of the active compound combination according to claim 1 for treating the seeds of transgenic plants.   Seeds treated with the active compound combination according to claim 1.   A method for controlling undesired phytopathogenic fungi, characterized in that the active compound combination according to claim 1 is applied to the undesired phytopathogenic fungi and / or their habitat and / or seeds. , Said method.   A method for preparing a fungicide composition, characterized in that the active compound combination according to claim 1 is mixed with a bulking agent and / or a surfactant.