JP2017518817A - 低エネルギープランジャ荷重を備えた自動注入器 - Google Patents
低エネルギープランジャ荷重を備えた自動注入器 Download PDFInfo
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- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/20—Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically
- A61M2005/2006—Having specific accessories
- A61M2005/2013—Having specific accessories triggering of discharging means by contact of injector with patient body
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M2005/3143—Damping means for syringe components executing relative movements, e.g. retarders or attenuators slowing down or timing syringe mechanisms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/32—Needles; Details of needles pertaining to their connection with syringe or hub; Accessories for bringing the needle into, or holding the needle on, the body; Devices for protection of needles
- A61M5/3205—Apparatus for removing or disposing of used needles or syringes, e.g. containers; Means for protection against accidental injuries from used needles
- A61M5/321—Means for protection against accidental injuries by used needles
- A61M5/3243—Means for protection against accidental injuries by used needles being axially-extensible, e.g. protective sleeves coaxially slidable on the syringe barrel
- A61M5/326—Fully automatic sleeve extension, i.e. in which triggering of the sleeve does not require a deliberate action by the user
- A61M2005/3267—Biased sleeves where the needle is uncovered by insertion of the needle into a patient's body
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- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
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- Environmental & Geological Engineering (AREA)
- Infusion, Injection, And Reservoir Apparatuses (AREA)
Abstract
Description
2014年7月1日出願の米国仮特許出願第62/019,729号の優先権の利益が主張され、この内容全体が、参照により本明細書に組み込まれるものとする。
(i)例えば、限定されることなく、その文献において説明される、抗体1A(DSMZ寄託番号DSM ACC 2586)、抗体8(DSMZ寄託番号DSM ACC 2589)、抗体23(DSMZ寄託番号DSM ACC 2588)、及び抗体18を含む、米国公開第2006/0040358号(2006年2月23日公開)、同第2005/0008642号(2005年1月13日公開)、同第2004/0228859号(2004年11月18日公開);
(ii)限定されることなく、それらの文献において説明される、抗体2F8、A12、及びIMC−A12を含む、PCT公開第WO06/138729号(2006年12月28日公開)、同第WO05/016970号(2005年2月24日公開)、及びLu et al.(2004),J.Biol.Chem.279:2856−2865;
(iii)PCT公開第WO07/012614号(2007年2月1日公開)、同第WO07/000328号(2007年1月4日公開)、同第WO06/013472号(2006年2月9日公開)、同第WO05/058967号(2005年6月30日公開)、及び同第WO03/059951号(2003年7月24日公開);
(iv)限定されることなく、それらの文献において説明される、抗体7C10、キメラ抗体C7C10、抗体h7C10、抗体7H2M、キメラ抗体*7C10、抗体GM607、ヒト化抗体7C10バージョン1、ヒト化抗体7C10バージョン2、ヒト化抗体7C10バージョン3、及び抗体7H2HMを含む、米国公開第2005/0084906号(2005年4月21日公開);
(v)限定されることなく、それらの文献において説明される、抗体EM164、最表面化EM164、ヒト化EM164、huEM164 v1.0、huEM164 v1.1、huEM164 v1.2、及びhuEM164 v1.3を含む、米国公開第2005/0249728号(2005年11月10日公開)、同第2005/0186203号(2005年8月25日公開)、同第2004/0265307号(2004年12月30日公開)、及び同第2003/0235582号(2003年12月25日公開)、並びにMaloney他(2003),Cancer Res.63:5073−5083;
(vi)限定されることなく、それらの文献において説明される、ATCC登録番号PTA−2792、PTA−2788、PTA−2790、PTA−2791、PTA−2789、PTA−2793を有するハイブリドーマによって生成される抗体、抗体2.12.1、2.13.2、2.14.3、3.1.1、4.9.2、及び4.17.3のそれぞれを含む、米国特許第7,037,498号(2006年5月2日発行)、米国公開第2005/0244408号(2005年11月30日公開)及び同第2004/0086503号(2004年5月6日公開)、並びにCohen他(2005)、Clinical Cancer Res.11:2063−2073の例えば抗体CP−751,871;
(vii)限定されることなく、それらの文献において説明される、19D12、並びにプラスミド15H12/19D12 HCA(γ4)のポリヌクレオチドによって符合化され、番号PTA−5214の下でATCCで寄託される重鎖、及びプラスミド15H12/19D12 LCF(κ)のポリヌクレオチドによって符合化され、番号PTA−5220の下でATCCで寄託される軽鎖を含む抗体、を含む、米国公開第2005/0136063号(2005年6月23日公開)及び同第2004/0018191号(2004年1月29日公開);並びに
(viii)限定されることなく、それらの文献において説明される、抗体PINT−6A1、PINT−7A2、PINT−7A4、PINT−7A5、PINT−7A6、PINT−8A1、PINT−9A2、PINT−11A1、PINT−11A2、PINT−11A3、PINT−11A4、PINT−11A5、PINT−11A7、PINT−11A12、PINT−12A1、PINT−12A2、PINT−12A3、PINT−12A4、及びPINT−12A5を含む、米国公開第2004/0202655号(2004年10月14日公開);これらの各々及び全てが参照によりそれらの全体が本明細書に組み込まれる、特にIGF−1受容体を標的にする上述した抗体、ペプチボディ、及び関連するタンパク質などに関するもの;
Claims (33)
- 薬物送達デバイスであって、
外部ケーシングと、
前記外部ケーシング内に配設され、かつ用量送達部材を担持する遠位端と、ストッパを担持する近位端と、前記遠位端と近位端との間に延在する内部チャンバとを備える一次容器であって、前記内部チャンバが、薬物を保管するためのものであり、前記ストッパが、前記遠位端で前記用量送達部材から前記薬物を吐出させるために、前記内部チャンバ内に移動可能に配設される、前記一次容器と、
前記外部ケーシング内に、かつ前記一次容器の前記近位端に近接して配設された注入駆動機構であって、前記注入駆動機構が、プランジャと、第1のエネルギー源の選択されたエネルギーとを備え、前記注入駆動機構の起動時に、前記第1のエネルギー源によって、前記プランジャが前記ストッパを前記一次容器の前記遠位端に向かって押し進めるように、前記第1のエネルギー源が前記プランジャに対して第1の力を及ぼす、注入駆動機構と、
前記外部ケーシング内に、かつ前記一次容器に近接して配設されたプランジャ荷重機構であって、前記プランジャ荷重機構が、前記一次容器を前記注入駆動機構に向かって付勢させるために、第2の力を前記一次容器に及ぼす第2のエネルギー源を備え、前記第2の力の大きさが、前記第1の力の大きさよりも小さく、これにより、起動時に、前記プランジャ荷重機構が、前記一次容器を前記注入駆動機構に向かって押し進め、前記ストッパと前記プランジャとの間の距離を低減し、これによって、前記プランジャが前記第1のエネルギー源によって所定の速度まで加速することを、それが前記ストッパに作用する前に防止する、プランジャ荷重機構と、を備える、薬物送達デバイス。 - 前記外部ケーシングが、管状側壁と、前記一次容器の前記用量送達部材に近接して配設され、かつ展開位置と格納位置との間で前記管状側壁に対して移動可能な針ガードと、を備える、請求項1に記載の薬物送達デバイス。
- 前記第2のエネルギー源が、前記外部ケーシングと前記一次容器との間に配設され、前記第2の力をこれらに印加する容器付勢部材を含む、請求項1または2に記載の薬物送達デバイス。
- 前記容器付勢部材が、コイルばねを含む、請求項3に記載の薬物送達デバイス。
- 前記容器付勢部材が、前記第2の力を前記針ガード及び前記一次容器に印加する、請求項3〜4のいずれか一項に記載の薬物送達デバイス。
- 前記付勢部材が、前記第2の力を前記管状側壁及び前記一次容器に印加する、請求項3〜4のいずれか一項に記載の薬物送達デバイス。
- 前記第1のエネルギー源が、コイルばね、ガス圧力配置、またはガス放出配置を含む、請求項1〜6のいずれか一項に記載の薬物送達デバイス。
- 前記外部ケーシング内に配設され、前記針ガードを前記展開位置に押し進める針ガード付勢部材を更に備える、請求項2〜7のいずれか一項に記載の薬物送達デバイス。
- 前記用量送達部材が、注入針を含む、請求項1〜8のいずれか一項に記載の薬物送達デバイス。
- 前記一次容器が、シリンジを含む、請求項1〜9のいずれか一項に記載の薬物送達デバイス。
これはテストであり、これはテストにすぎない。 - 前記デバイスが、使用準備済みモードにあるとき、前記一次容器を選択的にロックし、前記プランジャ荷重機構の前記第2の力に抵抗するためのキャリアロックを更に備え、これによって、前記一次容器の前記注入駆動機構に対する移動を制限する、請求項1〜10のいずれか一項に記載の薬物送達デバイス。
- 前記デバイスが、使用準備済みモードにあるとき、前記注入駆動機構を選択的にロックし、前記第1の力に抵抗するための注入駆動ロックを更に備え、これによって、前記プランジャの前記一次容器に対する移動を制限する、請求項1〜11のいずれか一項に記載の薬物送達デバイス。
- 前記一次容器の前記内部チャンバ内に保管された薬物を更に含む、請求項1〜12のいずれか一項に記載の薬物送達デバイス。
- 前記外部ケーシング内に配設され、前記一次容器を所定の軸位置に向かって付勢する容器ばねを更に備える、請求項1〜13のいずれか一項に記載の薬物送達デバイス。
- 薬物送達デバイスであって、
外部ケーシングと、
前記外部ケーシング内に配設され、用量送達部材を担持する遠位端と、移動可能なストッパを担持する近位端と、薬物を保管するための内部チャンバと、を備える一次容器と、
前記外部ケーシング内に、かつ前記一次容器の前記近位端に近接して配設された注入駆動機構であって、前記注入駆動機構が、プランジャと、第1のエネルギー源とを備え、前記第1のエネルギー源が、第1の力を前記プランジャに及ぼす、注入駆動機構と、
前記外部ケーシング内に、かつ前記一次容器に近接して配設されたプランジャ荷重機構であって、前記一次容器を前記注入駆動機構に向かって付勢するために、第2の力を前記一次容器に及ぼす第2のエネルギー源を備える、プランジャ荷重機構と、
前記プランジャ荷重機構がロックされかつ準備が整った使用準備済みモードであって、前記プランジャが、前記一次容器の前記ストッパから第1の距離離れて離間配置されている、使用準備済みモードと、
前記注入駆動機構がロックされかつ準備が整った動作モードであって、前記プランジャが、前記ストッパから第2の距離離れて位置付けられており、前記第2の距離が、前記第1の距離よりも小さい、動作モードと、を備える、薬物送達デバイス。 - 前記第2の力が、前記第1の力よりも小さい、請求項15に記載の薬物送達デバイス。
- 前記外部ケーシングが、管状側壁と、前記一次容器の前記用量送達部材に近接して配設され、かつ展開位置と格納位置との間で前記管状側壁に対して移動可能な針ガードと、を備える、請求項15〜16のいずれか一項に記載の薬物送達デバイス。
- 前記第2のエネルギー源が、前記外部ケーシングと前記一次容器との間に配設され、前記第2の力をこれらに印加する容器付勢部材を含む、請求項15〜17のいずれか一項に記載の薬物送達デバイス。
- 前記容器付勢部材が、コイルばねを含む、請求項18に記載の薬物送達デバイス。
- 前記容器付勢部材が、前記第2の力を前記針ガード及び前記一次容器に印加する、請求項18〜19のいずれか一項に記載の薬物送達デバイス。
- 前記付勢部材が、前記第2の力を前記管状側壁及び前記一次容器に印加する、請求項18〜19のいずれか一項に記載の薬物送達デバイス。
- 前記第1のエネルギー源が、コイルばね、ガス圧力配置、またはガス放出配置を含む、請求項15〜21のいずれか一項に記載の薬物送達デバイス。
- 前記外部ケーシング内に配設され、前記針ガードを前記展開位置に押し進める針ガード付勢部材を更に備える、請求項17〜22のいずれか一項に記載の薬物送達デバイス。
- 前記用量送達部材が、注入針を含む、請求項15〜23のいずれか一項に記載の薬物送達デバイス。
- 前記一次容器が、シリンジを含む、請求項15〜24のいずれか一項に記載の薬物送達デバイス。
- 前記デバイスが、前記使用準備済みモードにあるとき、前記一次容器を選択的にロックし、前記プランジャ荷重機構の前記第2の力に抵抗するためのキャリアロックを更に備え、これによって、前記一次容器の前記注入駆動機構に対する移動を制限する、請求項15〜25のいずれか一項に記載の薬物送達デバイス。
- 前記デバイスが、前記使用準備済みモードにあるとき、前記注入駆動機構を選択的にロックし、前記第1の力に抵抗するための注入駆動ロックを更に備え、これによって、前記プランジャの前記一次容器に対する移動を制限する、請求項15〜26のいずれか一項に記載の薬物送達デバイス。
- 前記一次容器の前記内部チャンバ内に保管された薬物を更に含む、請求項15〜25のいずれか一項に記載の薬物送達デバイス。
- 前記外部ケーシング内に配設され、前記一次容器を所定の軸位置に向かって付勢する容器ばねを更に備える、請求項15〜28のいずれか一項に記載の薬物送達デバイス。
- 薬物を投与するための方法であって、
用量送達部材を担持する遠位端と、ストッパを担持する近位端と、前記近位端と前記遠位端との間に延在し、かつ薬物を収容する内部チャンバと、を備える一次容器を提供することであって、前記ストッパが、前記用量送達部材から前記薬物を吐出させるために、前記容器の前記内部チャンバ内に移動可能に配設される、前記一次容器を提供することと、
前記一次容器の前記近位端に近接する注入駆動機構であって、プランジャと第1のエネルギー源とを備える、前記注入駆動機構を提供することと、
前記一次容器に近接して配設されたプランジャ荷重機構であって、第2のエネルギー源を備える、前記プランジャ荷重機構を提供することと、
前記プランジャ荷重機構の前記第2のエネルギー源によって発生した第2の力を印加することによって、前記一次容器と前記注入駆動機構との間の距離を低減し、これによって、前記注入駆動機構の前記プランジャと前記一次容器の前記ストッパとの間の距離を低減することと、
前記一次容器を前記注入駆動機構に向かって移動させた後に、前記注入駆動機構の前記第1のエネルギー源によって発生した第1の力を印加することによって、前記プランジャを前記一次容器の前記遠位端に向かって移動させ、これによって、前記ストッパを、前記近位端から前記遠位端まで前記一次容器の前記内部チャンバ内を移動させ、前記用量送達部材から前記薬物を吐出させることと、を含む、方法。 - 前記一次容器と前記注入駆動機構との間の距離を低減することが、前記プランジャ及び前記ストッパを互いに接触させることを含む、請求項30に記載の方法。
- 前記プランジャを前記一次容器の前記遠位端に向かって移動させることが、前記第1の力で前記第2の力に打ち勝つことを含む、請求項30〜31のいずれか一項に記載の方法。
- 前記一次容器と前記注入駆動機構との間の距離を低減することが、前記プランジャ荷重機構の前記第2のエネルギー源によって、前記一次容器を前記注入駆動機構に向かって移動させることを含む、請求項30〜32のいずれか一項に記載の方法。
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