JP2017516832A5 - - Google Patents

Info

Publication number

JP2017516832A5

JP2017516832A5 JP2016571196A JP2016571196A JP2017516832A5 JP 2017516832 A5 JP2017516832 A5 JP 2017516832A5 JP 2016571196 A JP2016571196 A JP 2016571196A JP 2016571196 A JP2016571196 A JP 2016571196A JP 2017516832 A5 JP2017516832 A5 JP 2017516832A5

Authority

JP

Japan

Prior art keywords

use according

pharmaceutical composition

prostaglandin

inhibitors

formulated

Prior art date

2014-06-06

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Pending

Links

• Espacenet
• Global Dossier
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• 230000000694 effects Effects 0.000 claims description 3
• 229940035676 analgesics Drugs 0.000 claims description 2
• 239000000730 antalgic agent Substances 0.000 claims description 2
• 239000008194 pharmaceutical composition Substances 0.000 claims 9
• 239000003112 inhibitor Substances 0.000 claims 8
• 150000003180 prostaglandins Chemical class 0.000 claims 4
• RZVAJINKPMORJF-UHFFFAOYSA-N Acetaminophen Chemical compound CC(=O)NC1=CC=C(O)C=C1 RZVAJINKPMORJF-UHFFFAOYSA-N 0.000 claims 2
• HEFNNWSXXWATRW-UHFFFAOYSA-N Ibuprofen Chemical compound CC(C)CC1=CC=C(C(C)C(O)=O)C=C1 HEFNNWSXXWATRW-UHFFFAOYSA-N 0.000 claims 2
• 102000015433 Prostaglandin Receptors Human genes 0.000 claims 2
• 108010050183 Prostaglandin Receptors Proteins 0.000 claims 2
• 102100027187 Solute carrier organic anion transporter family member 2A1 Human genes 0.000 claims 2
• 101710095536 Solute carrier organic anion transporter family member 2A1 Proteins 0.000 claims 2
• 230000000202 analgesic effect Effects 0.000 claims 2
• 238000013265 extended release Methods 0.000 claims 2
• 229960001680 ibuprofen Drugs 0.000 claims 2
• 239000012729 immediate-release (IR) formulation Substances 0.000 claims 2
• 230000037361 pathway Effects 0.000 claims 2
• 230000002686 anti-diuretic effect Effects 0.000 claims 1
• 230000001022 anti-muscarinic effect Effects 0.000 claims 1
• 230000002921 anti-spasmodic effect Effects 0.000 claims 1
• 229940124538 antidiuretic agent Drugs 0.000 claims 1
• 239000003160 antidiuretic agent Substances 0.000 claims 1
• 230000015572 biosynthetic process Effects 0.000 claims 1
• 239000000812 cholinergic antagonist Substances 0.000 claims 1
• 230000003111 delayed effect Effects 0.000 claims 1
• 239000002702 enteric coating Substances 0.000 claims 1
• 238000009505 enteric coating Methods 0.000 claims 1
• 238000002347 injection Methods 0.000 claims 1
• 239000007924 injection Substances 0.000 claims 1
• 238000004519 manufacturing process Methods 0.000 claims 1
• 210000003205 muscle Anatomy 0.000 claims 1
• 206010029446 nocturia Diseases 0.000 claims 1
• 229960005489 paracetamol Drugs 0.000 claims 1
• 239000008177 pharmaceutical agent Substances 0.000 claims 1
• 239000000825 pharmaceutical preparation Substances 0.000 claims 1
• 230000037081 physical activity Effects 0.000 claims 1
• 238000003786 synthesis reaction Methods 0.000 claims 1
• ZAFYATHCZYHLPB-UHFFFAOYSA-N zolpidem Chemical compound N1=C2C=CC(C)=CN2C(CC(=O)N(C)C)=C1C1=CC=C(C)C=C1 ZAFYATHCZYHLPB-UHFFFAOYSA-N 0.000 claims 1
• 229960001475 zolpidem Drugs 0.000 claims 1
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• NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 description 2
• UCSJYZPVAKXKNQ-HZYVHMACSA-N streptomycin Chemical compound CN[C@H]1[C@H](O)[C@@H](O)[C@H](CO)O[C@H]1O[C@@H]1[C@](C=O)(O)[C@H](C)O[C@H]1O[C@@H]1[C@@H](NC(N)=N)[C@H](O)[C@@H](NC(N)=N)[C@H](O)[C@H]1O UCSJYZPVAKXKNQ-HZYVHMACSA-N 0.000 description 2
• JKMHFZQWWAIEOD-UHFFFAOYSA-N 2-[4-(2-hydroxyethyl)piperazin-1-yl]ethanesulfonic acid Chemical compound OCC[NH+]1CCN(CCS([O-])(=O)=O)CC1 JKMHFZQWWAIEOD-UHFFFAOYSA-N 0.000 description 1
• 108091003079 Bovine Serum Albumin Proteins 0.000 description 1
• 102000009024 Epidermal Growth Factor Human genes 0.000 description 1
• 101800003838 Epidermal growth factor Proteins 0.000 description 1
• 102000018233 Fibroblast Growth Factor Human genes 0.000 description 1
• 108050007372 Fibroblast Growth Factor Proteins 0.000 description 1
• 239000007995 HEPES buffer Substances 0.000 description 1
• 102000004877 Insulin Human genes 0.000 description 1
• 108090001061 Insulin Proteins 0.000 description 1
• ZDXPYRJPNDTMRX-VKHMYHEASA-N L-glutamine Chemical compound OC(=O)[C@@H](N)CCC(N)=O ZDXPYRJPNDTMRX-VKHMYHEASA-N 0.000 description 1
• 229930182816 L-glutamine Natural products 0.000 description 1
• 229930182555 Penicillin Natural products 0.000 description 1
• JGSARLDLIJGVTE-MBNYWOFBSA-N Penicillin G Chemical compound N([C@H]1[C@H]2SC([C@@H](N2C1=O)C(O)=O)(C)C)C(=O)CC1=CC=CC=C1 JGSARLDLIJGVTE-MBNYWOFBSA-N 0.000 description 1
• 239000012980 RPMI-1640 medium Substances 0.000 description 1
• 238000012258 culturing Methods 0.000 description 1
• 230000006862 enzymatic digestion Effects 0.000 description 1
• 229940116977 epidermal growth factor Drugs 0.000 description 1
• 238000013401 experimental design Methods 0.000 description 1
• 239000012894 fetal calf serum Substances 0.000 description 1
• 229940126864 fibroblast growth factor Drugs 0.000 description 1
• 238000000338 in vitro Methods 0.000 description 1
• 229940125396 insulin Drugs 0.000 description 1
• 239000002609 medium Substances 0.000 description 1
• 229940049954 penicillin Drugs 0.000 description 1
• 229960005322 streptomycin Drugs 0.000 description 1
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