JP2017514910A5 - - Google Patents
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- Publication number
- JP2017514910A5 JP2017514910A5 JP2017510457A JP2017510457A JP2017514910A5 JP 2017514910 A5 JP2017514910 A5 JP 2017514910A5 JP 2017510457 A JP2017510457 A JP 2017510457A JP 2017510457 A JP2017510457 A JP 2017510457A JP 2017514910 A5 JP2017514910 A5 JP 2017514910A5
- Authority
- JP
- Japan
- Prior art keywords
- compound
- pharmaceutically acceptable
- represented
- following formula
- acceptable salt
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000001875 compounds Chemical class 0.000 claims 16
- 150000003839 salts Chemical class 0.000 claims 10
- 239000011780 sodium chloride Substances 0.000 claims 10
- 229910052739 hydrogen Inorganic materials 0.000 claims 3
- 239000001257 hydrogen Substances 0.000 claims 3
- 208000003432 Bone Disease Diseases 0.000 claims 2
- 150000002431 hydrogen Chemical class 0.000 claims 2
- 206010017076 Fracture Diseases 0.000 claims 1
- 206010049088 Osteopenia Diseases 0.000 claims 1
- 208000001132 Osteoporosis Diseases 0.000 claims 1
- 125000000217 alkyl group Chemical group 0.000 claims 1
- 239000003085 diluting agent Substances 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 159000000000 sodium salts Chemical class 0.000 claims 1
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201461987739P | 2014-05-02 | 2014-05-02 | |
US61/987,739 | 2014-05-02 | ||
PCT/US2015/028917 WO2015168636A1 (en) | 2014-05-02 | 2015-05-01 | Bone-selective osteogenic oxysterol bisphosphonate analogs |
Publications (3)
Publication Number | Publication Date |
---|---|
JP2017514910A JP2017514910A (ja) | 2017-06-08 |
JP2017514910A5 true JP2017514910A5 (US20080131398A1-20080605-C00009.png) | 2018-06-14 |
JP6530056B2 JP6530056B2 (ja) | 2019-06-12 |
Family
ID=54359404
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2017510457A Expired - Fee Related JP6530056B2 (ja) | 2014-05-02 | 2015-05-01 | 骨選択的骨形成オキシステロールビスホスホネート類似体 |
Country Status (7)
Families Citing this family (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1993558B1 (en) | 2006-02-27 | 2014-07-30 | The Regents of The University of California | Oxysterol compounds and the hedgehog pathway |
CA2872751A1 (en) | 2012-05-07 | 2013-11-14 | The Regents Of The University Of California | Oxysterol analogue oxy133 induces osteogenesis and hedgehog signaling and inhibits adipogenesis |
CN105263500A (zh) | 2013-05-02 | 2016-01-20 | 加利福尼亚大学董事会 | 骨选择性成骨性氧固醇-骨靶向剂 |
US9611288B2 (en) | 2014-12-09 | 2017-04-04 | Warsaw Orthopedic, Inc. | Compounds and methods involving sterols |
US10632230B2 (en) | 2015-07-10 | 2020-04-28 | Warsaw Orthopedic, Inc. | Implants having a high drug load of an oxysterol and methods of use |
US9877836B2 (en) | 2015-07-10 | 2018-01-30 | Warsaw Orthopedic, Inc. | Compression resistant implants including an oxysterol and methods of use |
US9987289B2 (en) | 2015-07-10 | 2018-06-05 | Warsaw Orthopedic, Inc. | Slow release oxysterols and methods of use |
US9637514B1 (en) | 2015-10-26 | 2017-05-02 | MAX BioPharma, Inc. | Oxysterols and hedgehog signaling |
US20170275330A1 (en) * | 2016-03-28 | 2017-09-28 | Warsaw Orthopedic, Inc. | Polymorphic forms of an oxysterol and methods of making them |
US10688222B2 (en) | 2016-11-21 | 2020-06-23 | Warsaw Orthopedic, Inc. | Lyophilized moldable implants containing an oxysterol |
US11384114B2 (en) | 2016-12-09 | 2022-07-12 | Warsaw Orthopedic, Inc. | Polymorphic forms of an oxysterol and methods of making them |
US10294264B2 (en) * | 2017-04-21 | 2019-05-21 | Warsaw Orthopedic, Inc. | Oxysterol-therapeutic agent derivative for bone healing |
US10434106B2 (en) | 2017-05-19 | 2019-10-08 | Warsaw Orthopedic, Inc. | Oxysterol-statin compounds for bone growth |
US11464888B2 (en) | 2017-06-12 | 2022-10-11 | Warsaw Orthopedic, Inc. | Moldable formulations containing an oxysterol in an acellular tissue matrix |
US12049475B2 (en) * | 2018-07-23 | 2024-07-30 | Brise Pharmaceuticals Co., Ltd. | Bisphosphonate drug conjugates |
Family Cites Families (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4559157A (en) | 1983-04-21 | 1985-12-17 | Creative Products Resource Associates, Ltd. | Cosmetic applicator useful for skin moisturizing |
LU84979A1 (fr) | 1983-08-30 | 1985-04-24 | Oreal | Composition cosmetique ou pharmaceutique sous forme aqueuse ou anhydre dont la phase grasse contient un polyether oligomere et polyethers oligomeres nouveaux |
US4820508A (en) | 1987-06-23 | 1989-04-11 | Neutrogena Corporation | Skin protective composition |
US4992478A (en) | 1988-04-04 | 1991-02-12 | Warner-Lambert Company | Antiinflammatory skin moisturizing composition and method of preparing same |
US5183815A (en) * | 1991-01-22 | 1993-02-02 | Merck & Co., Inc. | Bone acting agents |
EP0496520A1 (en) * | 1991-01-22 | 1992-07-29 | Merck & Co. Inc. | Novel bone acting agents |
JP2746041B2 (ja) | 1992-02-14 | 1998-04-28 | 三菱化学株式会社 | 新規なステロイド誘導体 |
JPH06329697A (ja) * | 1993-03-25 | 1994-11-29 | Kowa Co | 骨疾患治療剤 |
DE102004032781A1 (de) * | 2004-01-23 | 2005-08-11 | Mcs Micro Carrier Systems Gmbh | Bisphosphonsäurederivate |
EP1993558B1 (en) | 2006-02-27 | 2014-07-30 | The Regents of The University of California | Oxysterol compounds and the hedgehog pathway |
EP2114415A4 (en) * | 2007-02-23 | 2012-10-17 | Univ Louisville Res Found | METHOD AND COMPOUNDS FOR THE TARGETED RELEASE OF ACTIVE SUBSTANCES IN BONES FOR INTERACTION THEREOF |
AU2008331808B2 (en) * | 2007-03-16 | 2014-08-21 | The Regents Of The University Of California | Oxysterols for activation of hedgehog signaling, osteoinduction, antiadipogenesis, and Wnt signaling |
WO2012024584A2 (en) * | 2010-08-20 | 2012-02-23 | Fate Therapeutics, Inc. | Oxysterol compounds |
CA2872751A1 (en) * | 2012-05-07 | 2013-11-14 | The Regents Of The University Of California | Oxysterol analogue oxy133 induces osteogenesis and hedgehog signaling and inhibits adipogenesis |
WO2013169397A1 (en) | 2012-05-07 | 2013-11-14 | The Regents Of The University Of California | Novel oxysterol analogue, oxy149, induces osteogenesis and hedgehog signaling and inhibits adipogenesis |
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2015
- 2015-05-01 WO PCT/US2015/028917 patent/WO2015168636A1/en active Application Filing
- 2015-05-01 JP JP2017510457A patent/JP6530056B2/ja not_active Expired - Fee Related
- 2015-05-01 CN CN201580021530.7A patent/CN106232612B/zh not_active Expired - Fee Related
- 2015-05-01 US US15/302,154 patent/US10421773B2/en active Active
- 2015-05-01 EP EP15786795.3A patent/EP3137480A4/en not_active Withdrawn
- 2015-05-01 AU AU2015252859A patent/AU2015252859B2/en not_active Ceased
- 2015-05-01 CA CA2945404A patent/CA2945404A1/en not_active Abandoned