JP2017512999A - 液相に分散したタンパク質のラマン分光法による構造調査 - Google Patents

液相に分散したタンパク質のラマン分光法による構造調査 Download PDF

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JP2017512999A
JP2017512999A JP2016558758A JP2016558758A JP2017512999A JP 2017512999 A JP2017512999 A JP 2017512999A JP 2016558758 A JP2016558758 A JP 2016558758A JP 2016558758 A JP2016558758 A JP 2016558758A JP 2017512999 A JP2017512999 A JP 2017512999A
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sample
raman
protein
dispersed
detector
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JP2017512999A5 (https=
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イー． ネイル ルイス
イー． ネイル ルイス
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マルバーン インストゥルメンツ リミテッド
マルバーン インストゥルメンツ リミテッド
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Publication of JP2017512999A publication Critical patent/JP2017512999A/ja
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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N11/00—Investigating flow properties of materials, e.g. viscosity, plasticity; Analysing materials by determining flow properties
    • G01N11/02—Investigating flow properties of materials, e.g. viscosity, plasticity; Analysing materials by determining flow properties by measuring flow of the material
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/65—Raman scattering
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N11/00—Investigating flow properties of materials, e.g. viscosity, plasticity; Analysing materials by determining flow properties
    • G01N2011/006—Determining flow properties indirectly by measuring other parameters of the system
    • G01N2011/008—Determining flow properties indirectly by measuring other parameters of the system optical properties

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  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Physics & Mathematics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Investigating Or Analysing Materials By Optical Means (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
JP2016558758A 2014-03-25 2015-03-25 液相に分散したタンパク質のラマン分光法による構造調査 Pending JP2017512999A (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201461970198P 2014-03-25 2014-03-25
US61/970,198 2014-03-25
US201462026563P 2014-07-18 2014-07-18
US62/026,563 2014-07-18
PCT/GB2015/050892 WO2015145149A1 (en) 2014-03-25 2015-03-25 Raman spectroscopic structure investigation of proteins dispersed in a liquid phase

Publications (2)

Publication Number Publication Date
JP2017512999A true JP2017512999A (ja) 2017-05-25
JP2017512999A5 JP2017512999A5 (https=) 2018-04-19

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ID=52814134

Family Applications (1)

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JP2016558758A Pending JP2017512999A (ja) 2014-03-25 2015-03-25 液相に分散したタンパク質のラマン分光法による構造調査

Country Status (5)

Country Link
US (1) US20180180549A1 (https=)
EP (1) EP3123150A1 (https=)
JP (1) JP2017512999A (https=)
CN (1) CN106030278A (https=)
WO (1) WO2015145149A1 (https=)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR112018014870A2 (pt) * 2016-01-21 2018-12-11 Protein Dynamic Solutions Llc método e sistema para análise de dados espectrais
CN107132209A (zh) * 2017-04-28 2017-09-05 南京理工大学 一种基于纳米银/氧化石墨烯/氯化钠的拉曼增强基底免标记检测牛血清蛋白的方法
CN109063413B (zh) * 2018-06-07 2021-04-06 浙江工业大学 一种群体爬山迭代蛋白质构象空间优化方法
MY204234A (en) 2018-08-27 2024-08-16 Regeneron Pharma Use of raman spectroscopy in downstream purification
US11698304B2 (en) * 2019-02-15 2023-07-11 Wayne State University Apparatuses, systems, and methods for detecting materials based on Raman spectroscopy
CN111474133B (zh) * 2020-03-31 2023-06-06 上海理工大学 检测胎盘素里黄体酮和雌酮两种激素的方法
FR3112856B1 (fr) * 2020-07-27 2022-11-11 Univ Grenobles Alpes Procede de determination des parametres rheologiques d’un fluide
EP4308918A4 (en) * 2021-03-18 2025-01-08 Complete Omics International Inc. METHODS AND SYSTEMS FOR DETECTING AND QUANTIFYING A LARGE NUMBER OF MOLECULAR BIOMARKERS FROM A BODY FLUID SAMPLE
CN114199852B (zh) * 2021-12-07 2024-03-01 天津大学 一种药物共晶性能的表征方法

Citations (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5796476A (en) * 1995-06-28 1998-08-18 Kyoto Dai-Ichi Kagaku Co., Ltd. Method of optically measuring component in solution
JP2004507296A (ja) * 2000-08-21 2004-03-11 ザ　ジェネラル　ホスピタル　コーポレーション 神経変性状態の診断方法
JP2004527757A (ja) * 2001-05-05 2004-09-09 メルク　パテント　ゲゼルシャフト　ミット　ベシュレンクテル　ハフトング 溶液中の揮発性物質を特定する方法および装置
US20090037027A1 (en) * 2004-01-14 2009-02-05 Chevron Phillips Chemical Company Lp Method and Apparatus for Monitoring Polyolefin Production
US20100211329A1 (en) * 2007-10-12 2010-08-19 Stuart Farquharson Method and apparatus for determining properties of fuels
WO2011116402A2 (en) * 2010-03-19 2011-09-22 University Of Wyoming, An Institution Of Higher Education Of The State Of Wyoming Surface enhanced raman spectroscopy
JP2012507283A (ja) * 2008-10-31 2012-03-29 バイオメリュー・インコーポレイテッド ラマン分光法を使用した微生物の分離、キャラクタリゼーションおよび／または同定方法
WO2013027034A1 (en) * 2011-08-19 2013-02-28 Malvern Instruments Limited Dual-mode characterization of particulates
JP2013517485A (ja) * 2010-01-22 2013-05-16 ブリティッシュ コロンビア キャンサー エージェンシー ブランチ ラマン分光法による肺組織を特徴付けるための装置および方法
JP2013541711A (ja) * 2010-09-17 2013-11-14 アッヴィ・インコーポレイテッド バイオプロセス操作用のラマン分光法
US20150038347A1 (en) * 2010-03-19 2015-02-05 The University of Wyoming,an institution of higher of the State of Wyoming Surface enhanced raman spectroscopy

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7057732B2 (en) * 1999-01-25 2006-06-06 Amnis Corporation Imaging platform for nanoparticle detection applied to SPR biomolecular interaction analysis
US6875973B2 (en) * 2000-08-25 2005-04-05 Amnis Corporation Auto focus for a flow imaging system
US6961599B2 (en) * 2001-01-09 2005-11-01 Childrens Hospital Los Angeles Identifying or measuring selected substances or toxins in a subject using resonant raman signals
US20060023219A1 (en) * 2001-03-28 2006-02-02 Meyer Michael G Optical tomography of small objects using parallel ray illumination and post-specimen optical magnification
JP2007500529A (ja) * 2003-07-31 2007-01-18 コーニンクレッカ　フィリップス　エレクトロニクス　エヌ　ヴィ 生体管構造を流れる流体の性状を決定する開口数可変の方法および装置
US7440101B2 (en) * 2004-01-23 2008-10-21 Beckman Coulter, Inc. System and method for multiple laser triggering
EP1794324A4 (en) * 2004-09-20 2010-04-14 Wisconsin Alumni Res Found NONLINEAR SPECTROSCOPIC PROCEDURES FOR IDENTIFICATION AND DESCRIPTION OF MOLECULAR INTERACTIONS
WO2009038908A1 (en) * 2007-08-13 2009-03-26 C8 Medisensors Inc. Calibrated analyte concentration measurements in mixtures
US7920261B2 (en) * 2008-02-11 2011-04-05 Massachusetts Institute Of Technology Method and apparatus for detecting and discriminating particles in a fluid
US20120225475A1 (en) * 2010-11-16 2012-09-06 1087 Systems, Inc. Cytometry system with quantum cascade laser source, acoustic detector, and micro-fluidic cell handling system configured for inspection of individual cells

Patent Citations (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5796476A (en) * 1995-06-28 1998-08-18 Kyoto Dai-Ichi Kagaku Co., Ltd. Method of optically measuring component in solution
JP2004507296A (ja) * 2000-08-21 2004-03-11 ザ　ジェネラル　ホスピタル　コーポレーション 神経変性状態の診断方法
JP2004527757A (ja) * 2001-05-05 2004-09-09 メルク　パテント　ゲゼルシャフト　ミット　ベシュレンクテル　ハフトング 溶液中の揮発性物質を特定する方法および装置
US20090037027A1 (en) * 2004-01-14 2009-02-05 Chevron Phillips Chemical Company Lp Method and Apparatus for Monitoring Polyolefin Production
US20100211329A1 (en) * 2007-10-12 2010-08-19 Stuart Farquharson Method and apparatus for determining properties of fuels
JP2012507283A (ja) * 2008-10-31 2012-03-29 バイオメリュー・インコーポレイテッド ラマン分光法を使用した微生物の分離、キャラクタリゼーションおよび／または同定方法
JP2013517485A (ja) * 2010-01-22 2013-05-16 ブリティッシュ コロンビア キャンサー エージェンシー ブランチ ラマン分光法による肺組織を特徴付けるための装置および方法
WO2011116402A2 (en) * 2010-03-19 2011-09-22 University Of Wyoming, An Institution Of Higher Education Of The State Of Wyoming Surface enhanced raman spectroscopy
US20150038347A1 (en) * 2010-03-19 2015-02-05 The University of Wyoming,an institution of higher of the State of Wyoming Surface enhanced raman spectroscopy
JP2013541711A (ja) * 2010-09-17 2013-11-14 アッヴィ・インコーポレイテッド バイオプロセス操作用のラマン分光法
WO2013027034A1 (en) * 2011-08-19 2013-02-28 Malvern Instruments Limited Dual-mode characterization of particulates
JP2014524581A (ja) * 2011-08-19 2014-09-22 マルバーン インストゥルメンツ リミテッド 微粒子のデュアルモード特徴付け

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
N. V. SUROVTSEV ET AL.: "Glycine phases formed from frozen aqueous solutions: Revisited", THE JOURNAL OF CHEMICAL PHYSICS, vol. 137, JPN7019000511, 2012, US, pages 1 - 065103, ISSN: 0004126580 *

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WO2015145149A1 (en) 2015-10-01
EP3123150A1 (en) 2017-02-01
CN106030278A (zh) 2016-10-12
US20180180549A1 (en) 2018-06-28

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