JP2017512769A - アルツハイマー病の治療のための６−置換エストラジオール誘導体 - Google Patents

アルツハイマー病の治療のための６−置換エストラジオール誘導体 Download PDF

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Publication number
JP2017512769A
JP2017512769A JP2016556841A JP2016556841A JP2017512769A JP 2017512769 A JP2017512769 A JP 2017512769A JP 2016556841 A JP2016556841 A JP 2016556841A JP 2016556841 A JP2016556841 A JP 2016556841A JP 2017512769 A JP2017512769 A JP 2017512769A
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JP
Japan
Prior art keywords
methyl
cyclopenta
phenanthrene
decahydro
diol
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Pending
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JP2016556841A
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English (en)
Japanese (ja)
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JP2017512769A5 (enExample
Inventor
ヤーガー，ジェームス，ジー．
ナイ，スティーブン，エイチ．
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Endece LLC
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Endece LLC
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Publication of JP2017512769A publication Critical patent/JP2017512769A/ja
Publication of JP2017512769A5 publication Critical patent/JP2017512769A5/ja
Pending legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
JP2016556841A 2014-03-19 2015-03-19 アルツハイマー病の治療のための６−置換エストラジオール誘導体 Pending JP2017512769A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201461955578P 2014-03-19 2014-03-19
US61/955,578 2014-03-19
PCT/US2015/021538 WO2015143201A2 (en) 2014-03-19 2015-03-19 6-substituted estradiol derivatives for the treatment of alzheimer's disease

Publications (2)

Publication Number Publication Date
JP2017512769A true JP2017512769A (ja) 2017-05-25
JP2017512769A5 JP2017512769A5 (enExample) 2018-04-26

Family

ID=54141046

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2016556841A Pending JP2017512769A (ja) 2014-03-19 2015-03-19 アルツハイマー病の治療のための６−置換エストラジオール誘導体

Country Status (11)

Country Link
US (1) US20150265630A1 (enExample)
EP (1) EP3119402A4 (enExample)
JP (1) JP2017512769A (enExample)
KR (1) KR20160136363A (enExample)
CN (1) CN106255501A (enExample)
AU (2) AU2015231172A1 (enExample)
BR (1) BR112016021408A2 (enExample)
CA (1) CA2940536A1 (enExample)
MX (1) MX2016012045A (enExample)
SG (1) SG11201607693WA (enExample)
WO (1) WO2015143201A2 (enExample)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SG11202109152UA (en) 2019-06-03 2021-12-30 Aihol Corp Hyaluronan conjugates and uses thereof
US20210024568A1 (en) * 2019-07-23 2021-01-28 Endece Llc Methods for modulation of lipoprotein lipase and apolipoprotein c2 expression and/or activity in the treatment of peripheral and central nervous system tissue disease states

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008100560A2 (en) * 2007-02-14 2008-08-21 University Of Southern California Estrogen receptor modulators, associated pharmaceutical compositions and methods of use
WO2012129324A2 (en) * 2011-03-21 2012-09-27 Endece Llc 6-substituted estradiol derivatives for use in remyelination of nerve axons
JP2013512260A (ja) * 2009-11-30 2013-04-11 エンディース インコーポレイテッド ６−置換エストラジオール誘導体およびその使用方法

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008100560A2 (en) * 2007-02-14 2008-08-21 University Of Southern California Estrogen receptor modulators, associated pharmaceutical compositions and methods of use
JP2013512260A (ja) * 2009-11-30 2013-04-11 エンディース インコーポレイテッド ６−置換エストラジオール誘導体およびその使用方法
WO2012129324A2 (en) * 2011-03-21 2012-09-27 Endece Llc 6-substituted estradiol derivatives for use in remyelination of nerve axons

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
ENDOCRINOLOGY, vol. 149, no. 2, JPN6019001020, 2008, pages 711 - 716, ISSN: 0004092317 *
THE JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 260, no. 3, JPN6019001021, 1985, pages 1676 - 1681, ISSN: 0004092318 *
THE JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 277, no. 14, JPN6019001019, 2002, pages 12128 - 12136, ISSN: 0004092316 *

Also Published As

Publication number Publication date
WO2015143201A2 (en) 2015-09-24
KR20160136363A (ko) 2016-11-29
MX2016012045A (es) 2017-01-19
BR112016021408A2 (pt) 2017-12-19
US20150265630A1 (en) 2015-09-24
AU2018201003A1 (en) 2018-03-01
CN106255501A (zh) 2016-12-21
EP3119402A2 (en) 2017-01-25
AU2015231172A1 (en) 2016-09-08
EP3119402A4 (en) 2017-11-01
SG11201607693WA (en) 2016-10-28
CA2940536A1 (en) 2015-09-24

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