JP2017512762A - 薬学的に妥当な芳香族カチオン性ペプチド及びその生成方法 - Google Patents

薬学的に妥当な芳香族カチオン性ペプチド及びその生成方法 Download PDF

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Publication number
JP2017512762A
JP2017512762A JP2016555478A JP2016555478A JP2017512762A JP 2017512762 A JP2017512762 A JP 2017512762A JP 2016555478 A JP2016555478 A JP 2016555478A JP 2016555478 A JP2016555478 A JP 2016555478A JP 2017512762 A JP2017512762 A JP 2017512762A
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acid
compound
formula
hydrogen
hexafluorophosphate
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Japanese (ja)
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JP2017512762A5 (enExample
Inventor
ディー トラヴィス ウィルソン
ディー トラヴィス ウィルソン
Original Assignee
ステルス バイオセラピューティックス コープ
ステルス バイオセラピューティックス コープ
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Publication of JP2017512762A publication Critical patent/JP2017512762A/ja
Publication of JP2017512762A5 publication Critical patent/JP2017512762A5/ja
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1021—Tetrapeptides with the first amino acid being acidic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0802—Tripeptides with the first amino acid being neutral
    • C07K5/0812—Tripeptides with the first amino acid being neutral and aromatic or cycloaliphatic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0815—Tripeptides with the first amino acid being basic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0815—Tripeptides with the first amino acid being basic
    • C07K5/0817—Tripeptides with the first amino acid being basic the first amino acid being Arg
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1002—Tetrapeptides with the first amino acid being neutral
    • C07K5/1016—Tetrapeptides with the first amino acid being neutral and aromatic or cycloaliphatic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2016555478A 2014-03-03 2014-12-23 薬学的に妥当な芳香族カチオン性ペプチド及びその生成方法 Pending JP2017512762A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201461947286P 2014-03-03 2014-03-03
US61/947,286 2014-03-03
PCT/US2014/072267 WO2015134096A1 (en) 2014-03-03 2014-12-23 Pharmaceutically relevant aromatic-cationic peptides

Publications (2)

Publication Number Publication Date
JP2017512762A true JP2017512762A (ja) 2017-05-25
JP2017512762A5 JP2017512762A5 (enExample) 2018-02-08

Family

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JP2016555478A Pending JP2017512762A (ja) 2014-03-03 2014-12-23 薬学的に妥当な芳香族カチオン性ペプチド及びその生成方法

Country Status (7)

Country Link
US (1) US20170081363A1 (enExample)
EP (1) EP3114136A4 (enExample)
JP (1) JP2017512762A (enExample)
CN (1) CN106459169A (enExample)
CA (1) CA2942143A1 (enExample)
HK (1) HK1231493A1 (enExample)
WO (1) WO2015134096A1 (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2023132352A1 (ja) * 2022-01-06 2023-07-13 中外製薬株式会社 アミド化合物の製造方法

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2015100376A1 (en) 2013-12-27 2015-07-02 Stealth Peptides International, Inc. Pharmaceutically relevant aromatic-cationic peptides
EP3800192A1 (en) 2015-03-06 2021-04-07 Stealth Biotherapeutics Corp Processes for preparing pharmaceutically relevant peptides
JPWO2017043626A1 (ja) * 2015-09-11 2018-06-21 株式会社カネカ 光学活性４−カルバモイル−２，６−ジメチルフェニルアラニン誘導体の製造法
AU2017249218B2 (en) 2016-04-11 2020-08-27 Arcuate Therapeutics, Inc. Chiral peptides
WO2018187400A1 (en) 2017-04-05 2018-10-11 Stealth Biotherapeutics Corp. Crystalline salt forms of boc-d-arg-dmt-lys-(boc)-phe-nh2
US20200361987A1 (en) * 2017-11-15 2020-11-19 Stealth Biotherapeutics Corp. Deuterated tetrapeptides that target mitochondria
US10676506B2 (en) 2018-01-26 2020-06-09 Stealth Biotherapeutics Corp. Crystalline bis- and tris-hydrochloride salt of elamipretide
EP3898653A4 (en) 2018-12-18 2022-08-24 Stealth BioTherapeutics Inc. ANALOGS TARGETING MITOCHONDRIAL DISEASES

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2007503461A (ja) * 2003-05-01 2007-02-22 コーネル リサーチ ファウンデイション インコーポレイテッド 細胞に分子を送達する方法及び担体複合体

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002000263A2 (en) * 2000-06-14 2002-01-03 Medarex, Inc. Tripeptide prodrug compounds
US20070213505A1 (en) * 2006-03-08 2007-09-13 David Epstein Solution Synthesis of Peptide Cell Growth Stimulators
WO2011116007A1 (en) * 2010-03-15 2011-09-22 Stealth Peptides International, Inc. Combination therapies using cyclosporine and aromatic cationic peptides
CN105126071A (zh) * 2011-06-14 2015-12-09 康肽德生物医药技术有限公司 芳香族阳离子肽及其用途
HK1204988A1 (en) * 2012-02-22 2015-12-11 Stealth Peptides International, Inc. Methods and compositions for preventing or treating ophthalmic conditions
EP3459598A1 (en) * 2012-12-06 2019-03-27 Stealth Peptides International, Inc. Combinations of peptide therapeutics and methods for using same

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2007503461A (ja) * 2003-05-01 2007-02-22 コーネル リサーチ ファウンデイション インコーポレイテッド 細胞に分子を送達する方法及び担体複合体

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
"6 Solution-Phase Peptide SynthesisYuko Tsuda and Yoshio Okada", AMINO ACIDS, PEPTIDES AND PROTEINS IN ORGANIC CHEMISTRY, vol. 3, JPN6018044306, 2011, pages 201 - 251, ISSN: 0004086021 *
EUR. J. MED. CHEM., vol. 35, JPN6018044298, 2000, pages 895 - 901, ISSN: 0004086020 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2023132352A1 (ja) * 2022-01-06 2023-07-13 中外製薬株式会社 アミド化合物の製造方法

Also Published As

Publication number Publication date
CN106459169A (zh) 2017-02-22
WO2015134096A1 (en) 2015-09-11
EP3114136A4 (en) 2017-11-01
HK1231493A1 (zh) 2017-12-22
US20170081363A1 (en) 2017-03-23
EP3114136A1 (en) 2017-01-11
CA2942143A1 (en) 2015-09-11

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