JP2017511387A5 - - Google Patents
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- JP2017511387A5 JP2017511387A5 JP2017506619A JP2017506619A JP2017511387A5 JP 2017511387 A5 JP2017511387 A5 JP 2017511387A5 JP 2017506619 A JP2017506619 A JP 2017506619A JP 2017506619 A JP2017506619 A JP 2017506619A JP 2017511387 A5 JP2017511387 A5 JP 2017511387A5
- Authority
- JP
- Japan
- Prior art keywords
- bryostatin
- pharmaceutical composition
- composition according
- once
- weeks
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- MJQUEDHRCUIRLF-TVIXENOKSA-N bryostatin 1 Chemical group C([C@@H]1CC(/[C@@H]([C@@](C(C)(C)/C=C/2)(O)O1)OC(=O)/C=C/C=C/CCC)=C\C(=O)OC)[C@H]([C@@H](C)O)OC(=O)C[C@H](O)C[C@@H](O1)C[C@H](OC(C)=O)C(C)(C)[C@]1(O)C[C@@H]1C\C(=C\C(=O)OC)C[C@H]\2O1 MJQUEDHRCUIRLF-TVIXENOKSA-N 0.000 claims description 19
- 229960005539 bryostatin 1 Drugs 0.000 claims description 10
- 229960005520 bryostatin Drugs 0.000 claims description 9
- MUIWQCKLQMOUAT-AKUNNTHJSA-N bryostatin 20 Natural products COC(=O)C=C1C[C@@]2(C)C[C@]3(O)O[C@](C)(C[C@@H](O)CC(=O)O[C@](C)(C[C@@]4(C)O[C@](O)(CC5=CC(=O)O[C@]45C)C(C)(C)C=C[C@@](C)(C1)O2)[C@@H](C)O)C[C@H](OC(=O)C(C)(C)C)C3(C)C MUIWQCKLQMOUAT-AKUNNTHJSA-N 0.000 claims description 9
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 4
- 208000035475 disorder Diseases 0.000 claims description 4
- 230000006372 lipid accumulation Effects 0.000 claims description 4
- 208000010577 Niemann-Pick disease type C Diseases 0.000 claims description 3
- 208000007930 Type C Niemann-Pick Disease Diseases 0.000 claims description 3
- 235000020777 polyunsaturated fatty acids Nutrition 0.000 claims description 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 21
- 102000003923 Protein Kinase C Human genes 0.000 claims 6
- 108090000315 Protein Kinase C Proteins 0.000 claims 6
- 239000012190 activator Substances 0.000 claims 4
- 201000011240 Frontotemporal dementia Diseases 0.000 claims 2
- 208000000609 Pick Disease of the Brain Diseases 0.000 claims 2
- 208000024571 Pick disease Diseases 0.000 claims 2
- BSNHYLUEHJOXFN-HBUIWOJHSA-N 87370-86-3 Chemical compound C([C@@H]1[C@H]2OC(=O)C=C2[C@@H]([C@@](C(C)(C)/C=C/2)(O)O1)OC(=O)/C=C/C=C/CCC)[C@H]([C@@H](C)O)OC(=O)C[C@H](O)C[C@@H](O1)C[C@H](OC(C)=O)C(C)(C)[C@]1(O)C[C@@H]1C\C(=C\C(=O)OC)C[C@H]\2O1 BSNHYLUEHJOXFN-HBUIWOJHSA-N 0.000 claims 1
- 208000014060 Niemann-Pick disease Diseases 0.000 claims 1
- 102000018779 Replication Protein C Human genes 0.000 claims 1
- 108010027647 Replication Protein C Proteins 0.000 claims 1
- AVJAOOKIOFJJOC-UHFFFAOYSA-N bryostatin 10 Natural products CC1(C)C=CC(O2)CC(=CC(=O)OC)CC2CC(C(C(OC(=O)C(C)(C)C)C2)(C)C)(O)OC2CC(O)CC(=O)OC(C(C)O)CC2CC(=CC(=O)OC)CC1(O)O2 AVJAOOKIOFJJOC-UHFFFAOYSA-N 0.000 claims 1
- UYHQBUSZLQOCRF-OYLGSXELSA-N bryostatin 13 Chemical compound C([C@@H]1C[C@@H](C([C@@](O)(O1)C[C@@H]1CC(/C[C@@H](O1)/C=C/C1(C)C)=C/C(=O)OC)(C)C)OC(=O)CCC)[C@@H](O)CC(=O)O[C@@H]([C@H](C)O)C[C@@H]2C\C(=C/C(=O)OC)C[C@@]1(O)O2 UYHQBUSZLQOCRF-OYLGSXELSA-N 0.000 claims 1
- QMDQQCXRPALIRV-KPIQITSKSA-N bryostatin 16 Chemical compound C([C@H]1O[C@@](C([C@@H](OC(=O)C(C)(C)C)C1)(C)C)(O)C[C@@H]1C/C(C[C@H](/C=C/C2(C)C)O1)=C/C(=O)OC)[C@@H](O)CC(=O)O[C@@H]([C@@H](C)O)C[C@@H]1C\C(=C/C(=O)OC)C=C2O1 QMDQQCXRPALIRV-KPIQITSKSA-N 0.000 claims 1
- QMDQQCXRPALIRV-WFWQRCFSSA-N bryostatin 17 Chemical compound C([C@H]1O[C@@](C([C@@H](OC(=O)C(C)(C)C)C1)(C)C)(O)C[C@@H]1C/C(C[C@H](/C=C/C2(C)C)O1)=C/C(=O)OC)[C@@H](O)CC(=O)O[C@@H]([C@@H](C)O)C[C@@H]1C\C(=C\C(=O)OC)C=C2O1 QMDQQCXRPALIRV-WFWQRCFSSA-N 0.000 claims 1
- AVJAOOKIOFJJOC-VXOITNNESA-N bryostatin 18 Chemical compound C([C@H]1O[C@@](C([C@@H](OC(=O)C(C)(C)C)C1)(C)C)(O)C[C@@H]1C/C(C[C@H](/C=C/C2(C)C)O1)=C/C(=O)OC)[C@@H](O)CC(=O)O[C@@H]([C@@H](C)O)C[C@@H]1C\C(=C\C(=O)OC)C[C@@]2(O)O1 AVJAOOKIOFJJOC-VXOITNNESA-N 0.000 claims 1
- WUELAQMKFWZEMC-UOUXAWIZSA-N bryostatin 19 Chemical compound C/1=C/C(C)(C)C(O2)(O)C(OC(=O)CCC)C3=CC(=O)OC3C2CC(C(C)O)OC(=O)CC(O)CC(O2)CC(OC(=O)C(C)(C)C)C(C)(C)C2(O)CC2C\C(=C\C(=O)OC)CC\1O2 WUELAQMKFWZEMC-UOUXAWIZSA-N 0.000 claims 1
- LIPGUSBNMQRYNL-IZBIBDMISA-N bryostatin 2 Chemical compound C([C@@H]1CC(/[C@@H]([C@@](C(C)(C)/C=C/2)(O)O1)OC(=O)/C=C/C=C/CCC)=C\C(=O)OC)[C@H]([C@@H](C)O)OC(=O)C[C@H](O)C[C@@H](O1)C[C@H](O)C(C)(C)[C@]1(O)C[C@@H]1C\C(=C\C(=O)OC)C[C@H]\2O1 LIPGUSBNMQRYNL-IZBIBDMISA-N 0.000 claims 1
- OUVYQBNLDHLZNW-XLMAGYEKSA-N bryostatin 4 Chemical compound C([C@@H]1CC(/[C@@H]([C@@](C(C)(C)/C=C/2)(O)O1)OC(=O)CCC)=C\C(=O)OC)[C@H]([C@@H](C)O)OC(=O)C[C@H](O)C[C@@H](O1)C[C@H](OC(=O)CC(C)C)C(C)(C)[C@]1(O)C[C@@H]1C\C(=C/C(=O)OC)C[C@H]\2O1 OUVYQBNLDHLZNW-XLMAGYEKSA-N 0.000 claims 1
- JEHAMBABWZFXRB-YTTPNPLUSA-N bryostatin 5 Chemical compound C([C@H]1O[C@@](C([C@@H](OC(=O)CC(C)C)C1)(C)C)(O)C[C@@H]1C\C(C[C@H](/C=C/C2(C)C)O1)=C/C(=O)OC)[C@@H](O)CC(=O)O[C@@H]([C@@H](C)O)C[C@@H]1C\C(=C/C(=O)OC)[C@H](OC(C)=O)[C@@]2(O)O1 JEHAMBABWZFXRB-YTTPNPLUSA-N 0.000 claims 1
- COKSHECSBQOSFI-NZCKTZNVSA-N bryostatin 6 Chemical compound C([C@@H]1C[C@@H](C([C@@](O)(O1)C[C@@H]1CC(/C[C@@H](O1)/C=C/C1(C)C)=C/C(=O)OC)(C)C)OC(=O)CCC)[C@@H](O)CC(=O)O[C@@H]([C@@H](C)O)C[C@@H]2C\C(=C/C(=O)OC)[C@H](OC(C)=O)[C@@]1(O)O2 COKSHECSBQOSFI-NZCKTZNVSA-N 0.000 claims 1
- FCYKUTUWVZTVAK-LCPCCJDFSA-N bryostatin 7 Chemical compound C([C@H]1O[C@@](C([C@@H](OC(C)=O)C1)(C)C)(O)C[C@@H]1C/C(C[C@H](/C=C/C2(C)C)O1)=C/C(=O)OC)[C@@H](O)CC(=O)O[C@@H]([C@@H](C)O)C[C@@H]1C\C(=C/C(=O)OC)[C@H](OC(C)=O)[C@@]2(O)O1 FCYKUTUWVZTVAK-LCPCCJDFSA-N 0.000 claims 1
- SZVIECHSRIAHOF-LYSQEUSESA-N bryostatin 8 Chemical compound C([C@@H]1C[C@@H](C([C@@](O)(O1)C[C@@H]1CC(/C[C@@H](O1)/C=C/C1(C)C)=C/C(=O)OC)(C)C)OC(=O)CCC)[C@@H](O)CC(=O)O[C@@H]([C@@H](C)O)C[C@@H]2C\C(=C/C(=O)OC)[C@H](OC(=O)CCC)[C@@]1(O)O2 SZVIECHSRIAHOF-LYSQEUSESA-N 0.000 claims 1
- LJHLORJKOHOIPQ-NZCKTZNVSA-N bryostatin 9 Chemical compound C([C@@H]1CC(/[C@@H]([C@@](C(C)(C)/C=C/2)(O)O1)OC(=O)CCC)=C\C(=O)OC)[C@H]([C@@H](C)O)OC(=O)C[C@H](O)C[C@@H](O1)C[C@H](OC(C)=O)C(C)(C)[C@]1(O)C[C@@H]1C\C(=C\C(=O)OC)C[C@H]\2O1 LJHLORJKOHOIPQ-NZCKTZNVSA-N 0.000 claims 1
- AVJAOOKIOFJJOC-VADSYKNVSA-N chembl501262 Chemical compound C([C@H]1O[C@@](C([C@@H](OC(=O)C(C)(C)C)C1)(C)C)(O)C[C@@H]1C/C(C[C@H](/C=C/C2(C)C)O1)=C/C(=O)OC)[C@@H](O)CC(=O)O[C@@H]([C@@H](C)O)C[C@@H]1C\C(=C/C(=O)OC)C[C@@]2(O)O1 AVJAOOKIOFJJOC-VADSYKNVSA-N 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 238000000034 method Methods 0.000 description 3
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201461981473P | 2014-04-18 | 2014-04-18 | |
| US61/981,473 | 2014-04-18 | ||
| US201461987360P | 2014-05-01 | 2014-05-01 | |
| US61/987,360 | 2014-05-01 | ||
| PCT/US2015/025821 WO2015160851A1 (en) | 2014-04-18 | 2015-04-14 | Methods and compositions for treatment of lipid storage disorders |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2017511387A JP2017511387A (ja) | 2017-04-20 |
| JP2017511387A5 true JP2017511387A5 (cg-RX-API-DMAC7.html) | 2018-04-12 |
Family
ID=54321042
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017506619A Pending JP2017511387A (ja) | 2014-04-18 | 2015-04-14 | 脂質蓄積障害の治療のための方法および組成物 |
Country Status (9)
| Country | Link |
|---|---|
| US (3) | US9724328B2 (cg-RX-API-DMAC7.html) |
| EP (1) | EP3131543A4 (cg-RX-API-DMAC7.html) |
| JP (1) | JP2017511387A (cg-RX-API-DMAC7.html) |
| KR (1) | KR20170031653A (cg-RX-API-DMAC7.html) |
| CN (1) | CN107072982A (cg-RX-API-DMAC7.html) |
| CA (1) | CA2946115A1 (cg-RX-API-DMAC7.html) |
| IL (1) | IL248494A0 (cg-RX-API-DMAC7.html) |
| MX (1) | MX2016013680A (cg-RX-API-DMAC7.html) |
| WO (1) | WO2015160851A1 (cg-RX-API-DMAC7.html) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3501519B1 (en) | 2016-08-18 | 2024-11-20 | National University Corporation Nara Institute of Science and Technology | Bryostatin 1 for use in treating ige mediated allergic diseases |
| WO2019204582A1 (en) * | 2018-04-20 | 2019-10-24 | Retrotope, Inc. | Stabilized polyunsaturated compounds and uses thereof |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2003515601A (ja) | 1999-11-30 | 2003-05-07 | ボード オブ トラスティーズ オブ ザ レランド スタンフォード ジュニア ユニバーシティ | ブリオスタチンアナログ、合成方法および使用 |
| US7256286B2 (en) | 1999-11-30 | 2007-08-14 | The Board Of Trustees Of The Leland Stanford Junior University | Bryostatin analogues, synthetic methods and uses |
| AU2003281214A1 (en) | 2002-07-02 | 2004-01-23 | Blanchette Rockefeller Neurosciences Institute | PKC ACTIVATION AS A MEANS FOR ENHANCING sAPPAlpha SECRETION AND IMPROVING COGNITION USING BRYOSTATIN TYPE COMPOUNDS |
| US8497385B2 (en) | 2007-08-31 | 2013-07-30 | The Board Of Trustees Of The Leland Stanford Junior University | Bryostatin analogues, synthetic methods and uses |
| WO2009099563A2 (en) | 2008-02-05 | 2009-08-13 | Blanchette Rockefeller Neurosciences Institute | Combination of a nmda receptor channel blocker and a pkc activator for treatment of alzheimer's disease |
| US8163800B2 (en) | 2008-07-28 | 2012-04-24 | Blanchette Rockefeller Neurosciences Institute | PKC-activating compounds for the treatment of neurodegenerative diseases |
| WO2011019763A2 (en) | 2009-08-10 | 2011-02-17 | The Board Of Trustees Of The University Of Illinois | Compositions and methods for the treatment of krabbe and other neurodegenerative diseases |
| US10821079B2 (en) * | 2011-11-13 | 2020-11-03 | Cognitive Research Enterprises, Inc. | PKC activators and combinations thereof |
| EP3122351A1 (en) | 2014-03-27 | 2017-02-01 | Daniel L. Alkon | Compositions and methods to treat niemann-pick disease |
-
2015
- 2015-04-14 WO PCT/US2015/025821 patent/WO2015160851A1/en not_active Ceased
- 2015-04-14 JP JP2017506619A patent/JP2017511387A/ja active Pending
- 2015-04-14 KR KR1020167032127A patent/KR20170031653A/ko not_active Withdrawn
- 2015-04-14 US US14/686,711 patent/US9724328B2/en not_active Expired - Fee Related
- 2015-04-14 MX MX2016013680A patent/MX2016013680A/es unknown
- 2015-04-14 EP EP15780368.5A patent/EP3131543A4/en not_active Withdrawn
- 2015-04-14 US US15/304,838 patent/US20170172978A1/en not_active Abandoned
- 2015-04-14 CA CA2946115A patent/CA2946115A1/en not_active Abandoned
- 2015-04-14 CN CN201580032762.2A patent/CN107072982A/zh active Pending
-
2016
- 2016-10-25 IL IL248494A patent/IL248494A0/en unknown
-
2019
- 2019-01-15 US US16/247,880 patent/US20190201377A1/en not_active Abandoned