JP2017508443A - 細胞を含む液体媒体を処理するデバイス - Google Patents
細胞を含む液体媒体を処理するデバイス Download PDFInfo
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Abstract
Description
収量[%]=V生成物液体媒体・生成物濃度・100/V初期液体媒体・初期濃度
Claims (15)
- 生成物濃度の細胞を含む生成物液体媒体(4’)が得られるように、初期濃度の細胞を含む初期液体媒体(4)を処理するデバイスであって、該デバイス(2)が、
前記初期液体媒体(4)を様々な成分へと分離するよう適合されたセパレータ(6)と、
前記初期液体媒体(4)を前記セパレータ(6)に供給する第1の供給システム(8)と、
前記セパレータ(6)から前記生成物液体媒体(4’)を抜き出す第1の排出システム(12)と、
前記初期液体媒体(4)又は前記生成物液体媒体(4’)における前記細胞の濃度に関連する物理パラメータを測定するよう適合されたセンサ(22、22’)と、
前記センサ(22、22’)に接続し、該センサ(22、22’)により測定された前記物理パラメータに応じて前記デバイス(2)の少なくとも1つのプロセスパラメータを制御するよう適合されたコントロールユニット(24)と、
を備え、
溶液(18)を前記セパレータ(6)へと所与の流量にて供給する第2の供給システム(10)であって、該セパレータ(6)への該溶液の供給中の該第2の供給システム(10)における該溶液(18)の流量を前記少なくとも1つのプロセスパラメータに基づき決定する、第2の供給システムを特徴とする、デバイス。 - 前記コントロールユニット(24)が、前記初期液体媒体(4)にて測定された前記細胞の濃度が増大すると、前記第2の供給システム(10)における前記溶液(18)の流量が低減するよう構成されていることを特徴とする、請求項1に記載のデバイス。
- 前記少なくとも1つのプロセスパラメータによって、前記セパレータ(6)への初期液体媒体の供給中の前記第1の供給システム(8)における前記初期液体媒体(4)の流量、及び/又は前記セパレータ(6)からの前記生成物液体媒体の抜き出し中の前記第1の排出システム(12)における前記生成物液体媒体(4’)の流量を決定することを特徴とする、請求項1又は2に記載のデバイス。
- 前記コントロールユニット(24)が、前記初期液体媒体(4)の流量が前記第1の供給システム(8)における該初期液体媒体(4)中の前記細胞の初期濃度と反比例するように該初期液体媒体の流量を、及び/又は前記生成物液体媒体(4’)の流量が前記第1の供給システム(8)における前記初期液体媒体(4)中の前記細胞の初期濃度と正比例するように該生成物液体媒体(4’)の流量を制御するよう構成されていることを特徴とする、請求項3に記載のデバイス。
- 前記セパレータ(6)が遠心分離器であることを特徴とする、請求項1から4のいずれか一項に記載のデバイス。
- 前記コントロールユニット(24)が、前記遠心分離器の回転速度が前記第1の供給システム(8)における前記初期液体媒体(4)中の前記細胞の初期濃度と反比例するように、前記少なくとも1つのプロセスパラメータに基づき該回転速度を制御するよう構成されていることを特徴とする、請求項5に記載のデバイス。
- 前記第1の供給システム(8)が供給ライン(8b)を備え、その中を通って前記初期液体媒体(4)が前記セパレータ(6)へと流れ、かつ前記センサ(22)が前記第1の供給システム(8)の該供給ライン(8b)に存在する前記初期液体媒体(4)中の前記細胞の初期濃度に関連する物理パラメータを測定するよう適合されていることを特徴とする、請求項1から6のいずれか一項に記載のデバイス。
- 前記第1の排出システム(12)が排出ライン(12b)を備え、その中を通って前記生成物液体媒体(4’)が前記セパレータ(6)から流れ出て、かつ前記センサ(22’)が前記第1の排出システム(12)の該排出ライン(12b)に存在する前記生成物液体媒体(4’)中の前記細胞の生成物濃度に関連する物理パラメータを測定するよう適合されていることを特徴とする、請求項1から7のいずれか一項に記載のデバイス。
- 前記コントロールユニット(24)が、前記生成物液体媒体中の前記細胞の生成物濃度が既定の濃度範囲内となるように、前記デバイス(2)の少なくとも1つのプロセスパラメータを制御するよう構成されていることを特徴とする、請求項1から8のいずれか一項に記載のデバイス。
- 前記コントロールユニット(24)が、前記生成物液体媒体(4’)中の前記細胞の生成物濃度が最大となるように、前記デバイス(2)の少なくとも1つのプロセスパラメータを制御するよう構成されていることを特徴とする、請求項1から9のいずれか一項に記載のデバイス。
- 前記デバイス(2)がin vitroにて稼働するよう構成されていることを特徴とする、請求項1から10のいずれか一項に記載のデバイス。
- 前記初期液体媒体(4)中の前記細胞の濃度に関連する物理パラメータを測定するよう適合された第1のセンサ(22)と、前記生成物液体媒体(4’)中の前記細胞の濃度に関連する物理パラメータを測定するよう適合された第2のセンサ(22’)とを備えることを特徴とする、請求項1から11のいずれか一項に記載のデバイス。
- 生成物濃度の細胞を含む生成物液体媒体(4’)が得られるように、初期濃度の細胞を含む初期液体媒体(4)を処理する方法であって、該方法が、
前記初期液体媒体(4)をセパレータ(6)に第1の供給システム(8)を介して供給する工程と、
前記セパレータ(6)にて、前記生成物液体媒体(4’)が得られるように、前記初期液体媒体(4)を様々な成分へと分離する工程と、
前記セパレータ(6)から前記生成物液体媒体(4’)を第1の排出システム(12)を介して抜き出す工程と、
センサ(22、22’)を用いて、前記初期液体媒体(4)又は前記生成物液体媒体(4’)中の前記細胞の濃度に関連する物理パラメータを測定する工程と、
前記センサ(22、22’)により測定された前記物理パラメータに応じて少なくとも1つのプロセスパラメータを制御する工程と、
を含み、
前記初期液体媒体(4)を様々な成分へと分離する工程中に、溶液(18)を前記セパレータ(6)へと所与の流量にて第2の供給システム(10)を介して供給し、該溶液の該セパレータ(6)への供給中に該第2の供給システム(10)中の該溶液(18)の流量を前記少なくとも1つのプロセスパラメータに基づき決定することを特徴とする、方法。 - 請求項1から12のいずれか一項に記載のデバイス(2)を用いて行われることを特徴とする、請求項13に記載の方法。
- 前記液体媒体(4)が血球を含む血液であることを特徴とする、請求項13又は14に記載の方法。
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US10935540B2 (en) | 2015-08-03 | 2021-03-02 | Novartis Ag | GDF-15 as a haematological toxicity biomarker |
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WO2019119190A1 (zh) * | 2017-12-18 | 2019-06-27 | 深圳市大疆创新科技有限公司 | 植保机的液体抽取装置的流量控制方法、装置及系统 |
NZ770478A (en) | 2018-05-31 | 2023-05-26 | Vitalant | Methods and systems for cryopreservation and resuspension of body fluids |
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CN105873623A (zh) | 2016-08-17 |
US10022732B2 (en) | 2018-07-17 |
US20180333419A1 (en) | 2018-11-22 |
JP6427198B2 (ja) | 2018-11-21 |
US20160339451A1 (en) | 2016-11-24 |
US10632476B2 (en) | 2020-04-28 |
EP3099344A1 (en) | 2016-12-07 |
EP3099344B1 (en) | 2018-05-30 |
CN105873623B (zh) | 2019-03-29 |
WO2015110229A1 (en) | 2015-07-30 |
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