JP2017226652A5 - - Google Patents
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- Publication number
- JP2017226652A5 JP2017226652A5 JP2017117321A JP2017117321A JP2017226652A5 JP 2017226652 A5 JP2017226652 A5 JP 2017226652A5 JP 2017117321 A JP2017117321 A JP 2017117321A JP 2017117321 A JP2017117321 A JP 2017117321A JP 2017226652 A5 JP2017226652 A5 JP 2017226652A5
- Authority
- JP
- Japan
- Prior art keywords
- solvate
- salt
- general formula
- aqueous composition
- brimonidine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000003839 salts Chemical class 0.000 claims 5
- 239000011780 sodium chloride Substances 0.000 claims 5
- 239000012453 solvate Substances 0.000 claims 5
- XYLJNLCSTIOKRM-UHFFFAOYSA-N Alphagan Chemical compound C1=CC2=NC=CN=C2C(Br)=C1NC1=NCCN1 XYLJNLCSTIOKRM-UHFFFAOYSA-N 0.000 claims 3
- 229960003679 brimonidine Drugs 0.000 claims 3
- 150000001875 compounds Chemical class 0.000 claims 3
- 125000005843 halogen group Chemical group 0.000 claims 2
- 230000000087 stabilizing Effects 0.000 claims 1
- 0 CC(CNCCC1)N1S(c1c(c(*)cnc2)c2ccc1)(=O)=O Chemical compound CC(CNCCC1)N1S(c1c(c(*)cnc2)c2ccc1)(=O)=O 0.000 description 1
Claims (4)
（Ａ）ブリモニジン若しくはその塩又はそれらの溶媒和物；
（Ｂ）一般式（１）
で表される化合物若しくはその塩又はそれらの溶媒和物；
を含有する、水性組成物であって、成分（Ｂ）の含有量が、水性組成物全容量に対して、一般式（１）で表される化合物のフリー体に換算して０．２５〜６ｗ／ｖ％である、水性組成物。 The following components (A) and (B):
(A) Brimonidine or a salt thereof or a solvate thereof;
(B) General formula (1)
Or a salt thereof or a solvate thereof;
In which the content of the component (B) is 0.25 to 5 in terms of the free form of the compound represented by the general formula (1) with respect to the total volume of the aqueous composition. An aqueous composition that is 6 w / v% .
（Ａ）ブリモニジン若しくはその塩又はそれらの溶媒和物；
を含有する水性組成物に、次の成分（Ｂ）：
（Ｂ）一般式（１）
で表される化合物若しくはその塩又はそれらの溶媒和物；
を含有せしめる、水性組成物中のブリモニジン若しくはその塩又はそれらの溶媒和物の安定化方法。 Next component (A):
(A) Brimonidine or a salt thereof or a solvate thereof;
In the aqueous composition containing the following component (B):
(B) General formula (1)
Or a salt thereof or a solvate thereof;
A method for stabilizing brimonidine or a salt thereof or a solvate thereof in an aqueous composition, comprising
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2016119087 | 2016-06-15 | ||
| JP2016119087 | 2016-06-15 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019040561A Division JP2019081810A (en) | 2016-06-15 | 2019-03-06 | Aqueous composition ii |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017226652A JP2017226652A (en) | 2017-12-28 |
| JP2017226652A5 true JP2017226652A5 (en) | 2018-06-07 |
| JP6495379B2 JP6495379B2 (en) | 2019-04-03 |
Family
ID=60888987
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017117321A Active JP6495379B2 (en) | 2016-06-15 | 2017-06-15 | Aqueous composition |
| JP2019040561A Pending JP2019081810A (en) | 2016-06-15 | 2019-03-06 | Aqueous composition ii |
| JP2022033657A Pending JP2022078211A (en) | 2016-06-15 | 2022-03-04 | Aqueous composition 3 |
| JP2023194188A Pending JP2024020404A (en) | 2016-06-15 | 2023-11-15 | Aqueous composition 4 |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019040561A Pending JP2019081810A (en) | 2016-06-15 | 2019-03-06 | Aqueous composition ii |
| JP2022033657A Pending JP2022078211A (en) | 2016-06-15 | 2022-03-04 | Aqueous composition 3 |
| JP2023194188A Pending JP2024020404A (en) | 2016-06-15 | 2023-11-15 | Aqueous composition 4 |
Country Status (1)
| Country | Link |
|---|---|
| JP (4) | JP6495379B2 (en) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2019189721A1 (en) * | 2018-03-30 | 2019-10-03 | 千寿製薬株式会社 | Aqueous liquid formulation |
| JP6653037B2 (en) * | 2018-03-30 | 2020-02-26 | 千寿製薬株式会社 | Aqueous liquid |
| WO2019235456A1 (en) * | 2018-06-05 | 2019-12-12 | 千寿製薬株式会社 | Aqueous liquid agent |
| JP2020033290A (en) * | 2018-08-29 | 2020-03-05 | 興和株式会社 | Aqueous composition |
| JP6730500B2 (en) * | 2018-10-01 | 2020-07-29 | 千寿製薬株式会社 | Aqueous solution |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2013035802A (en) * | 2011-08-10 | 2013-02-21 | D Western Therapeutics Institute Inc | Prophylactic or therapeutic agent for glaucoma or ocular hypertension |
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2017
- 2017-06-15 JP JP2017117321A patent/JP6495379B2/en active Active
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2019
- 2019-03-06 JP JP2019040561A patent/JP2019081810A/en active Pending
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2022
- 2022-03-04 JP JP2022033657A patent/JP2022078211A/en active Pending
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2023
- 2023-11-15 JP JP2023194188A patent/JP2024020404A/en active Pending