JP2017205287A - Oral contraceptive taking scheduling system, oral contraceptive taking scheduling method, and program - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide an oral contraceptive taking scheduling system.SOLUTION: An oral contraceptive taking scheduling system comprises a continuous taking period of the oral contraceptive and a continuous taking-pause period when not-taking days continue according to a period to avoid menstruation. The oral contraceptive taking schedule system comprises: an acquisition unit for acquiring information about an avoidance period, the most recent medication days continuously taking the oral contraceptive, the most recent taking-pause days when not taking the oral contraceptive continuously, and the most recent menstruation day; a medication schedule search unit for searching for combination between the continuous taking period and the continuous taking-pause period, based on the information about the avoidance period, the most recent medication days, the most recent taking-pause days, and the most recent menstruation day; and an optimal schedule selection unit for selecting one or more combination sequentially from a smaller one of an absolute value difference between the continuous taking period included in the combination and the predetermined standard continuous medication days.SELECTED DRAWING: Figure 6

Description

  The present invention relates to an oral contraceptive dosage scheduling system, an oral contraceptive dosage scheduling method, and a program.

  Menstruation occurs with various physical and mental disorders such as premenstrual and menstrual pain associated with physical and mental distress, premenstrual syndrome, dysmenorrhea. There are various other problems besides pain, such as anxiety such as not knowing when menstruation is coming, making it impossible to plan travel or taking an examination, or worrying about menstrual blood adhering to clothes.

  As a method of dealing with this problem, a method of controlling the menstrual cycle by taking oral contraceptives (OC) for a certain period and taking a drug out is known. An oral contraceptive is a combination of two types of female hormones, follicular hormone (estrogen) and luteinizing hormone (progesterone). As a contraceptive method that can be performed mainly by women, one tablet a day, the same every day By taking in time, a high contraceptive effect can be expected, and the menstrual cycle can also be controlled by the above-mentioned two types of female hormones.

  Therefore, if oral contraceptives are used successfully, there will be no worries about menstrual periods such as menstrual pain and irregular menstrual periods, and women will be able to freely design their own lifestyles. Expected to be more active in society.

  For example, U.S. Patent No. 6,057,051 teaches a method and apparatus for use in monitoring the ovulation cycle in female animals.

Special table 2009-512871

  In the method of controlling the menstrual cycle with the above oral contraceptives, it is necessary to appropriately perform medication (and drug holiday) scheduling. In particular, there is a problem that medication scheduling becomes complicated when there are multiple or irregular days or periods in the schedule that are desired to be sorted out.

  However, the method and apparatus of Patent Document 1 cannot cope with the complicated medication scheduling of the oral contraceptive as described above.

Therefore, according to the first aspect of the present invention, the present invention is based on at least one consecutive day when a user takes an oral contraceptive according to at least one avoidance period pre-selected as a period to avoid menstruation. A scheduling system for setting an oral contraceptive medication schedule including one continuous medication period and at least one continuous medication holiday in which the user does not take oral contraceptives.
Information on the at least one avoidance period, the number of days in which the user has continuously taken oral contraceptives in the most recent setting date, which is the date for setting the oral contraceptive medication schedule, and the setting date An acquisition unit that acquires the latest drug holiday days indicating the number of days the user has not taken oral contraceptives most recently and the most recent menstrual day;
Based on the information about the avoidance period, the number of days of the latest medication, the number of days of the latest medication and the date of the latest menstrual period, at least one combination of the at least one continuous medication period and the at least one continuous medication period A medication schedule search unit to search;
One or more combinations are selected from the at least one combination in order from the smallest absolute value difference between the at least one continuous dosing period included in the at least one combination and the predetermined standard continuous dosing days An oral contraceptive medication scheduling system including an optimal schedule selection unit.

  Here, the “absolute value difference” in claim 1 means a value indicating the difference, and includes both the sum of the differences and a scaled sum of the differences (an average value or the like).

In the above oral contraceptive medication scheduling system,
The index of the searched at least one combination is i (i = 1,..., N _sch ), and j (j = 1,..., N _term ) of the at least one continuous dosing period included in the specific combination i. (I)) When the number of days of the first item is d (i, j), the standard number of continuous administration days is R ₁ , and the distance function is D (i), the optimal schedule selection unit
It is desirable to select one or a plurality of optimum combinations from the smaller value of the distance function D (i) according to the first criterion of reducing the distance function D (i) represented by

  According to such an oral contraceptive medication scheduling system, among the one or a plurality of candidate schedules searched by the medication schedule search unit, a schedule having a smaller absolute value difference between the number of days of the continuous medication period and the standard continuous medication days. Can be selected by the optimum schedule selection process and presented to the user.

In the above oral contraceptive medication scheduling system,
The optimal schedule selection unit selects a plurality of optimal combinations according to the first criterion,
According to the first criterion, according to the second criterion of reducing the variance {σ (i)} ² of the number of days d (i, j) of each of the at least one continuous dosing period included in the selected combination i It is desirable to select one or a plurality of combinations as the optimal combination from the plurality of the selected optimal combinations, in which the value of the variance {σ (i)} ² is smaller.

  According to such an oral contraceptive medication scheduling system, when the absolute value difference between the number of days of the continuous medication period and the standard continuous medication days is equal between one or a plurality of candidate schedules searched by the medication schedule search unit. A schedule with less variation between continuous periods can be selected by the optimal schedule selection process and presented to the user.

In the above oral contraceptive medication scheduling system, the standard continuous medication days may be R ₁ = 21.

  In the above oral contraceptive medication scheduling system, there is at least one acceptable number of days of the latest drug holiday between at least two latest medication periods in which the user has taken oral contraceptives in the immediate vicinity of the set date. In this case, the number of days of the latest medication may be calculated as the total number of days of the at least two latest medication periods and an allowable number of days of the at least one recent medication period.

  According to such an oral contraceptive medication scheduling system, the oral contraceptive medication scheduling algorithm can be prevented from becoming complicated.

  In the above oral contraceptive medication scheduling system, the medication schedule search unit is based on a predetermined criterion for determining the medication or withdrawal of the medication or withdrawal on the day subject to determination of medication or withdrawal. It is desirable to search for a schedule that takes into account any case for a day on which neither medication nor drug withdrawal is determined, after determining the date on which the drug will be confirmed.

  According to such an oral contraceptive medication scheduling system, it is possible to reduce the number of cases of medication or drug withdrawal on the day of determination of each medication or medication holiday, so that the load of schedule search can be reduced.

In the above oral contraceptive medication scheduling system,
D _min represents the minimum number of days of continuous use of oral contraceptives for causing withdrawal bleeding, and R ₂ represents the standard number of consecutive withdrawal days required to cause withdrawal bleeding during the continuous withdrawal period. When the drug schedule search unit,
(1) The day before the date of the subject of determination of medication or drug withdrawal is the medication date, and the number of days of the latest medication up to the date of subject of judgment of the medication or drug withdrawal is {d _min -1} or less,
(2) The number of days of the latest medication up to the date on which the determination of the medication or drug withdrawal is {d _min -1} or more, and the first day of the avoidance period closest to the reference date is {R ₂ -1} days are within, and (3)該服agent or which days subjected to the determination of washout belongs to avoid periods,
In any of the cases, it is desirable to search for one or more candidate schedules in accordance with a criterion for determining the day for which the determination of medication or withdrawal is made as the medication date.

  According to such an oral contraceptive medication scheduling system, when searching for one or more candidate schedules, conditions to ensure withdrawal bleeding after a continuous medication period, withdrawal bleeding before the nearest avoidance period By taking into account the conditions for continuing to take the drug when it cannot be accelerated and the conditions for ensuring avoidance of menstruation (including withdrawal bleeding) during the avoidance period, Since it is possible to reduce the division in case of taking or taking medicine, the load of schedule search can be reduced.

In the oral contraceptives take scheduling system, causing withdrawal bleeding during the continuous washout period, and a standard continuous washout days required to end when the R _2, is該服agent schedule search unit, If該服agent or continuous washout days until the day to be determined washout is less than R _2, one according to the criteria to determine the day to be determined該服agent or washout as drug holiday Alternatively, it is desirable to search for a plurality of candidate schedules.

  According to such an oral contraceptive medication scheduling system, when searching for one or more candidate schedules, by considering the conditions for causing and terminating withdrawal bleeding during a continuous drug holiday In addition, since it is possible to reduce the number of cases of taking or taking medicines on the determination target day of each taking or taking medicine, it is possible to reduce the load of schedule search.

In the above oral contraceptive medication scheduling system, the shortest continuous medication days may be d _min = 14, the standard continuous medication days may be R ₁ = 21, and the standard continuous medication holidays may be R ₂ = 7.

According to the second aspect of the present invention, the present invention also provides the computer with a date when the user takes the oral contraceptive according to at least one avoidance period preselected as a period for avoiding menstruation. Oral for performing an oral contraceptive scheduling method that sets an oral contraceptive medication schedule that includes at least one continuous medication period and at least one continuous medication holiday that the user does not take oral contraceptives. A contraceptive medication scheduling program, wherein the computer operates as an oral contraceptive medication scheduling system including an acquisition unit, a medication schedule search unit, and an optimal schedule selection unit, the method comprising:
The acquisition unit has information on the at least one avoidance period, and the most recent medication days indicating the number of days that the user has continuously taken oral contraceptives most recently on the set date, which is the date on which the oral contraceptive medication schedule is set. A step of acquiring the most recent drug holiday indicating the number of days that the user has not continuously taken oral contraceptives in the most recent set date, and the most recent menstruation date,
The medication schedule search unit, based on the information on the avoidance period, the most recent medication days, the most recent medication days, and the most recent menstrual day, the at least one continuous medication period and the at least one continuous medication Searching for at least one combination of time periods;
The optimal schedule selection unit selects one of the at least one combination in order from the smallest absolute value difference between the at least one continuous dosing period included in the at least one combination and the predetermined standard continuous dosing days. Or a contraceptive scheduling program comprising selecting a plurality of combinations.

Further, according to the third aspect of the present invention, the present invention is pre-selected as a period for avoiding menstruation in an oral contraceptive medication scheduling system including an acquisition unit, a medication schedule search unit, and an optimal schedule selection unit. According to at least one avoidance period, at least one continuous dose period in which the user takes oral contraceptives is continuous, and at least one continuous drug holiday in which the user does not take oral contraceptives continues An oral contraceptive scheduling method for setting an oral contraceptive medication schedule including:
The acquisition unit has information on the at least one avoidance period, and the most recent medication days indicating the number of days that the user has continuously taken oral contraceptives most recently on the set date, which is the date on which the oral contraceptive medication schedule is set. A step of acquiring the most recent drug holiday indicating the number of days that the user has not continuously taken oral contraceptives in the most recent set date, and the most recent menstruation date,
The medication schedule search unit, based on the information on the avoidance period, the most recent medication days, the most recent medication days, and the most recent menstrual day, the at least one continuous medication period and the at least one continuous medication Searching for at least one combination of time periods;
The optimal schedule selection unit selects one of the at least one combination in order from the smallest absolute value difference between the at least one continuous dosing period included in the at least one combination and the predetermined standard continuous dosing days. Or selecting a plurality of combinations. An oral contraceptive scheduling method.

  According to the present invention, among one or a plurality of candidate schedules searched by the medication schedule search unit, a schedule having a smaller absolute value difference between the number of days in the continuous medication period and the standard continuous medication days is selected by the optimum schedule selection process. Can be presented to the user.

It is a figure which shows the network structure of the oral contraceptive medication scheduling system according to this invention. It is a figure which shows the hardware constitutions of the user terminal 104. 2 is a diagram illustrating a hardware configuration of Web servers 112 and 118. FIG. It is a figure which shows the hardware constitutions of the analysis servers 114 and 122. It is a figure which shows the hardware constitutions of the database servers 116 and 120. It is a flowchart which shows the oral contraceptive medication scheduling algorithm according to this embodiment. It is a figure which shows an example of a medication schedule candidate search. It is a flowchart which shows an example of the selection process of one or some optimal medication schedule. It shows the dosing schedule that resulted in accelerated withdrawal bleeding before the avoidance period. It shows the dosing schedule that resulted in delaying withdrawal bleeding after the avoidance period. There are multiple avoidance periods, showing a medication schedule that avoids them consecutively. There is a plurality of avoidance periods, and another example of a dosing schedule that avoids this continuously is shown. It is a figure which shows the example of a display of the calculation result of the oral contraceptive medication scheduling algorithm according to this embodiment. It is a figure which shows the example of a screen display in the user terminal of the oral contraceptive medication scheduling system according to this embodiment.

(1) Overall Network Configuration FIG. 1 is a diagram showing a network configuration of an oral contraceptive medication scheduling system according to the present invention.

The scheduling system 100 includes an analysis center 102, user terminals 104-1 (l = 1,..., N _u ), a medical institution 106, and an administrator terminal 108. The analysis center 102 includes a web server 112, an analysis server 114, and a database server 116. The medical institution 106 includes a Web server 118, a database server 120, an analysis server 122, a doctor terminal 124, and an input / output (I / O) interface 126 connected to the doctor terminal 124. The plurality of user terminals 104-1 are owned by the user, and access to the analysis server 114 of the analysis center 102 or the analysis server 122 of the medical institution 106, so that at least one of a plurality of candidates for oral contraceptive medication schedules is obtained. One that is used to receive the best. Here, the index l of the user terminal corresponds to the user ID. For example, the administrator terminal is owned by an administrator such as an exclusive trainer of a sports team to which the user l belongs, and the administrator terminal can access the database server 116 of the analysis center 102 or the database server 120 of the medical institution 106 so that the administrator can individually It is used to grasp the health status of the user l.

  The analysis center 102, the user terminal 104-1, the medical institution 106, and the administrator terminal 108 can communicate with each other via the communication network 110.

  The analysis center 102 may be a server room of a company or a government agency. The Web server 110 receives an HTTP request from the Web browser of the user terminal 104-1 and returns a response. In response to the processing request from the Web server 110, the analysis server 114 executes a calculation logic of an oral contraceptive (OC) dosage schedule for menstrual movement, and if necessary, refers to data reference to the database server 116, Make an update request. The database server 116 mainly manages data, performs data reference and update processing requests from the Web server 112, and returns the results.

The analysis server 114 includes the most recent medication days indicating the number of days the user has taken oral contraceptives immediately in the set date, which is the date for setting the oral contraceptive medication schedule, and the user continuously in the latest set date. The number of days of the most recent drug holiday that indicates the number of days that the oral contraceptive was not taken, the date of the user's menstrual period most recently set, and one or more avoidance periods determined by the user based on the user's schedule. Received from the terminal 104-l. Based on the received one or more avoidance periods, the number of days of the latest medication, the number of days of the most recent drug holiday, and the date of the latest user's menstruation, the analysis server 114 may receive one or more consecutive days on which the user takes oral contraceptives. One or a plurality of combinations (candidate schedules) of a plurality of continuous dosing periods and one or a plurality of continuous dosing periods in which the user does not take oral contraceptives continue. When the analysis server 114 searches for one or more candidate schedules, the drug or drug holiday is shifted if the target date for drug or drug holiday is shifted every day after the schedule period according to one or more rules. And all of one or more oral contraceptive medication schedule candidate sequences i (i = 1,..., N _sch ) are searched. The analysis server 114 selects an optimal candidate schedule from one or more searched candidate schedules according to at least one predetermined criterion. The Web server 112 and the analysis server 114 can be implemented by a computer such as a personal computer or a workstation.

  In Japan, oral contraceptives such as pills are required by law to be prescribed by doctors. Therefore, the medical institution 106 may be a server room in a hospital, for example. On the other hand, in other countries, it is possible to purchase oral contraceptives such as pills as over-the-counter drugs at general pharmacies. Therefore, alternatively, the medical institution 106 may be a server room in a pharmacy or a drug store, for example. The doctor or pharmacist can prescribe oral contraceptives such as pills by referring to the calculation results of the calculation logic of the oral contraceptive medication schedule according to the present embodiment. The functions and operations of the Web server 118, the database server 120, and the analysis server 122 of the medical institution 106 are the same as those of the analysis center 102. Therefore, if the program according to this embodiment stored in the database server 116 of the analysis center 102 is downloaded to the database server 120 of the medical institution 106, the medical institution 106 can perform the same processing as the analysis center 102. It is.

  The doctor terminal 124 is a terminal for a doctor, a pharmacist, or the like to refer to the user's body characteristic data, the user's schedule, the user's oral contraceptive medication record, the oral contraceptive medication schedule, and the like. It can be implemented by a computer such as a station. The I / O interface 126 includes a scanner, a printer, a display, a touch panel, and the like.

  When the request is first received from the browser of the user terminal 104-1, the analysis server 114 or 122 generates an identifier for uniquely identifying the browser, and the identifier is given to the web application on the web server 112 or 118. hand over. Thereafter, the analysis server 114 or 122 holds information on the Web browser in a persistent external resource that can be shared with the Web server 112 or 118 using the identifier as a key. The Web server 112 or 118 passes the identifier received from the analysis server 114 or 122 to the browser of the user terminal 104-1. For example, when using cookie, the Web server 112 or 118 can set an identifier for the cookie in the analysis server 114 or 122 by passing the cookie as an argument to the analysis server 114 or 122. When a request is made again from the browser of the user terminal 104-1, information can be acquired by referring to an external resource based on the identifier set by the analysis server 114 or 122.

(2) User Terminal and Web Server FIG. 2 is a diagram illustrating a hardware configuration of the user terminal 104.

  Each user terminal 104-1 includes a CPU 302, a memory 304, a storage device 306, an input unit 308, a transmission / reception interface (I / F) 310, and a display unit 312. The CPU 302 implements various functions by reading the program stored in the storage device 306 into the memory 304 and executing it. The memory 304 includes, for example, a random access memory (RAM) and / or a read only memory (ROM). The storage device 306 includes a tape drive, floppy drive, hard disk drive, or compact disk drive. The input unit 308 includes, for example, a keyboard, a mouse, a trackball, a touch panel, a microphone, and the like that accept data input. The display unit 312 includes, for example, a display and a speaker that output data. The user terminal 104-1 connects the transmission / reception interface 310 to an external printer or the like to thereby select one or more optimum selected from one or more candidate schedules of the oral contraceptive medication schedule from the analysis server 114. A schedule of taking oral contraceptives can be printed out.

  The transmission / reception interface 310 accesses the Web server 112 via the communication network 110 and transmits an HTTP request to the Web server 112. The transmission / reception interface 310 transmits user-related information such as a user ID and a password input on the web browser displayed on the display unit 312 to the web server 112 in response to the response to the HTTP request from the web server 112. To do. Thereby, the login to the site of the analysis center 102 by the user is completed.

  FIG. 3 is a diagram illustrating a hardware configuration of the Web servers 112 and 118.

  Each of the Web servers 112 and 118 includes a CPU 402, a memory 404, a storage device 406, an input unit 408, a transmission / reception interface (I / F) 410, and an output unit 412. The storage device 406 may be a hard disk drive, a solid state drive, a flash memory, or the like that stores various data and programs. The CPU 402 implements various functions by reading the program stored in the storage device 406 into the memory 404 and executing it. The transmission / reception interface 410 is an interface for connecting to the communication network 110, and is an adapter for connecting to Ethernet (registered trademark), a modem for connecting to a public telephone line network, or the like. The input unit 408 may be a keyboard, a mouse, a trackball, a touch panel, a microphone, or the like that receives data input. The output unit 412 may be a display, a printer, a speaker, or the like that outputs data.

(3) Analysis Server FIG. 4 is a diagram illustrating a hardware configuration of the analysis servers 114 and 122.

  The analysis servers 114 and 122 include a CPU 502, a memory 504, a storage device 506, an input unit 508, an output unit 510, a transmission / reception interface (I / F) 512, a user data search unit 514, and user data, respectively. An acquisition unit 516, a medication schedule search unit 518, and an optimal schedule selection unit 520 are included. The storage device 506 may be a hard disk drive, a solid state drive, a flash memory, or the like that stores various data and programs. The CPU 502 implements various functions by reading the program stored in the storage device 506 into the memory 504 and executing it. The transmission / reception interface 512 is an interface for connecting to the communication network 110, and is implemented by an adapter for connecting to Ethernet (registered trademark), a modem for connecting to a public telephone network, and the like. The input unit 508 may be a keyboard, mouse, trackball, touch panel, microphone, or the like that accepts data input. The output unit 510 may be a display, a printer, a speaker, or the like that outputs data. The transmission / reception I / F 512 includes the user data acquisition unit that receives the user's latest medication days, the latest drug holidays, the latest user's menstrual days, and one or more avoidance periods determined by the user, received from the user terminal 104-1. The user data acquisition unit 516 transmits the data to the medication schedule search unit 518. Also, the transmission / reception I / F 512 receives one or more oral contraceptive optimal dosage schedules selected by the optimal schedule selecting unit 520 from the optimal schedule selecting unit 520 and receives the received one or more oral contraceptive optimal dosage schedules from the user terminal. Send to 104-l.

  The user data search unit 514 searches the user information area of the database server 116 or 120 for user body characteristic data, user schedule, user medication record data, and user personal information. The user data acquisition unit 516 transmits / receives the user's most recent medication days, the most recent drug holidays, the most recent user's menstrual date, and one or more avoidance periods received by the transmission / reception I / F 512 from the user terminal 104-1. These data received from F512 are stored in the database server 116 or 120, and transmitted to the medication schedule search unit 518.

The medication schedule search unit 518 includes one or more avoidance periods based on the one or more avoidance periods received from the user terminal 104-1, the most recent medication days, the most recent drug holidays, and the most recent menstrual days. In order to prevent the occurrence of menstruation (including withdrawal bleeding) in the hospital, one or more consecutive dose periods in which the user takes oral contraceptives and the days in which the user does not take oral contraceptives are consecutive Search for candidate schedules that are one or more combinations of one or more consecutive drug holiday periods. When searching for one or more candidate schedules, the medication schedule search unit 518 shifts the target date for taking or taking a drug every day after the schedule period from one day before or after the schedule period according to one or more rules. Withdrawal is determined and all of one or more oral contraceptive medication schedule candidate sequences i (i = 1,..., N _sch ) are searched. The optimum schedule selection unit 520 selects one or more optimum candidate schedules from the searched one or more candidate schedules according to at least one predetermined criterion.

(4) Database Server FIG. 5 is a diagram showing the hardware configuration of the database servers 116 and 120.

  The database servers 116 and 120 are respectively a user body feature data database 602, a user schedule database 604, a user dose record data database 606, a user personal information database 608, a patient patient data database 610, and a doctor individual. An information database 612, a responsible user data database 614, and an administrator personal information database 616 are included. The user body feature data database 602, the user schedule database 604, the user dose record data database 606, and the user personal information database 608 form a user information area indexed by “user ID” l, and the patient in charge The data database 610 and the doctor personal information database 612 form a doctor information area indexed by “doctor ID” m, and the responsible user data database 614 and the administrator personal information database 616 include “manager ID” n To form an administrator information area to be indexed. Here, the “manager” is, for example, a manager or coach of a sports team or department to which the user belongs, a dedicated trainer, or the like.

  The user body feature data database 602 stores information related to the user's body features in a form associated with the “user ID” l. The user's medication record data database 606 includes continuous medication days indicating the number of days that the user l has continuously taken oral contraceptives and continuous medication days indicating the number of days that the user l has not taken oral contraceptives continuously. And the previous menstrual date of the user l and one or more avoidance periods determined by the user l based on the date and period of the user-specific event are stored in association with the calendar data. Data relating to the user's medication record is stored in association with the “user ID” l. The user personal information database 608 stores the personal information of the user l for each “user ID” l.

  The patient data database 610 stores information related to the physical characteristics of the user who is in charge of the doctor m in association with the “doctor ID” m. The doctor personal information database 612 stores personal information of the doctor m.

  The responsible user data database 614 stores information related to the physical characteristics of the user who is in charge of the manager n in association with the “manager ID” n. The manager personal information database 616 stores personal information of the manager m.

(5) Oral contraceptive taking scheduling algorithm FIG. 6 is a flowchart showing an oral contraceptive taking scheduling algorithm according to the present embodiment.

  The user data acquisition unit 516 of the analysis servers 114 and 122 acquires information regarding one or more avoidance periods determined by the user l (step S602). The one or more avoidance periods are periods determined by the user 1 on or before the scheduled date of oral contraceptive use to avoid menstruation within the one or more avoidance periods.

  In addition, the user data acquisition unit 516 is configured to display the most recent medication days indicating the number of days that the user l has continuously taken oral contraceptives immediately after the set date for setting the oral contraceptive medication schedule, and the user immediately after the set date. The most recent drug holiday indicating the number of days that the oral contraceptive was not taken continuously and the latest menstrual date of the set date are acquired (step S602). The number of days of the most recent medication means the number of days that the user l has continuously taken oral contraceptives immediately after the set date for setting the oral contraceptive medication schedule, but one during two or more recent medication periods. Or, if there are more than one acceptable number of recent holidays, the most recent sum of these two or more recent medication periods plus one or more recent holidays It may be acquired as the number of days taken. For example, when the date of medication is indicated by “◯” and the date of withdrawal is indicated by “X”, the medication schedule of the user l until the set date is indicated by “XX × XXX”. Sometimes, the drug holiday is treated as a medication day, and the most recent medication day is 5 days.

  In step S602, the user data acquisition unit 516 may receive information regarding one or more avoidance periods, the number of days of the latest medication, the number of days of the most recent drug holiday, and the date of the latest menstrual period from the user terminal 104-1. In addition, the user data acquisition unit 516 has the user data search unit 514 search the user dose record data database 606 of the database server 116 or 120, and information on one or more avoidance periods, the number of days of the latest medication, You may acquire the number of days of the latest drug holiday and the latest menstrual day.

  The user data acquisition unit 516 sends the acquired information on one or more avoidance periods, the number of days of the latest medication, the number of days of the latest drug holiday, and the date of the latest menstrual period to the medication schedule search unit 518, and the process is performed by the drug schedule search unit. 518 is taken over.

The medication schedule search unit 518 includes one or a plurality of continuous medication periods and one based on information on one or more avoidance periods determined by the user l, the most recent medication days, the most recent drug holidays, and the most recent menstrual days. One or more combinations of one or more consecutive drug holidays (one or more candidate sequences i (i = 1,..., N _sch ) of the oral contraceptive medication schedule are searched (step S604). Details of the candidate search will be described later with reference to FIG.

Thereafter, the medication schedule search unit 518 determines whether or not one or a plurality of avoidance periods determined by the user l can be handled based on the most recent medication days, the most recent drug holiday days, and the most recent menstrual day (step) S606). In the present embodiment, on the medication schedule setting date, the first avoidance period of the user who does not have the latest medication _{history is} less than d _stop until the next predicted menstrual day, and is a period within 6 days from the predicted menstrual date If it overlaps, it is determined that these avoidance periods cannot be handled (NO in step S606). This is a case where a minimum amount of continuous medication is required for the effect of deterring menstruation after the user l starts taking oral contraceptives, and the medication is taken from the medication schedule setting date to the avoidance period. Also because it is difficult to avoid menstruation. In this embodiment, d _stop = 5 days, but the variable can be changed as appropriate. In addition, even if you take the medication from the date you set the medication schedule, there is a high probability that you will become menstruated on the predicted menstrual period. Is also determined to be incompatible (NO in step S606).

  Further, in the present embodiment, as a result of the schedule search in step S604, it is determined that it is not possible to handle even when only a schedule candidate whose number of consecutive medication days is equal to or greater than a predetermined number of consecutive medication days (63 days or more) is searched (step NO in S606). This is a standard based on consideration of the influence of the medication on the user's body when the number of consecutive medication days continues for a predetermined number of days or more.

  As a result of the determination in step S606, when it is determined that the response is not possible, a proposal is made to prompt the user l to make a compromise (abandon menstruation avoidance) in one or a plurality of avoidance periods (step S608). Thereafter, when the medication schedule search unit 518 acquires from the user terminal 104-1 an avoidance period after compromise that compromises menstruation avoidance for any avoidance period (YES in step S 610), the process returns to step S 604 and avoids after compromise. Re-execute the schedule search for the period. On the other hand, if the medication schedule search unit 518 does not acquire the avoidance period after the compromise from the user terminal 104-1 (NO in step S 610), the medication schedule search unit 518 transmits a notification that the user terminal 104-1 cannot be handled. (Step S612) The process ends.

  As a result of the determination in step S606, when there is a schedule that can correspond to one or more avoidance periods determined by the user l, the medication schedule search unit 518 selects the searched one or more candidate schedules as the database server 116. Alternatively, the data is stored in the 120 user dosage record data database 606, and the process proceeds to the optimum schedule selection process (step S614). Details of the optimum schedule selection processing will be described later with reference to FIG. Thereafter, the medication schedule search unit 518 transmits the selected optimal schedule to the user terminal 104-1 (step S616), and ends the process.

Subsequently, the medication schedule candidate search process in step S604 of FIG. 6 will be described with reference to FIG. FIG. 7 is a diagram illustrating an example of a medication schedule candidate search. In the present embodiment, the medication schedule search unit 518 determines the medication or drug withdrawal while shifting the target date of medication or drug withdrawal from the front of the schedule period to the day after (day (1)). All of the oral contraceptive medication schedule candidate sequences i (i = 1,..., N _sch ) are searched. In this search, the medication schedule search unit 518 can apply the following rules (a) to (d). By applying this rule, there will be a day when the medication or withdrawal can be confirmed, and the number of cases of medication or withdrawal on the subject date for each medication or withdrawal can be reduced, thus reducing the burden of schedule search. be able to.

D _min , the minimum number of days of continuous use of oral contraceptives for causing withdrawal bleeding, standard continuous withdrawal required for causing withdrawal bleeding and termination during continuous withdrawal period If the number of days and _{R 2,} dosing schedule search unit 518,
(A) The day before the date of determination of medication or withdrawal is the date of medication, and the number of consecutive medication days up to the date of assessment is {d _min -1} or less ((A) hatched portion in FIG. 7) ,
(B) The number of days taken until the determination target date is {d _min -1} or more, and the first day of the avoidance period closest to the determination target date is within {R ₂ -1} days from the determination target date. Yes ((B) hatched portion in FIG. 7)
(C) The determination target date belongs to the avoidance period ((C) hatched portion in FIG. 7),
In any of the cases, the user l always takes the oral contraceptive on the determination target date, that is, the medication schedule search unit 518 sets the determination target date to the medication date. (A) is a condition for surely causing withdrawal bleeding after the continuous medication period, and (b) is a medication period because the withdrawal bleeding cannot be accelerated before the nearest avoidance period ( (C) is a condition for reliably avoiding menstruation (including withdrawal bleeding) in the avoidance period.

In addition, the medication schedule search unit 518
(D) The day before the determination target date is a drug holiday, and the number of drug holiday until the determination target date is less than R ₂ ((D) hatched portion in FIG. 7).
In this case, the user l always takes a drug holiday, that is, the medication schedule search unit 518 sets the determination target date as a drug holiday. (D) is a condition for causing and terminating withdrawal bleeding during the continuous drug holiday. In this embodiment, it is assumed that the standard continuous drug holiday days R ₂ = 7 and the shortest continuous dose days d _min = 14.

  Note that the rules for searching for schedule candidates are not limited to the above (a) to (d), and a rule may be added to reduce the case classification of each drug or drug holiday on the determination date of each drug or drug holiday. .

  Next, the optimum schedule selection process in step S614 in FIG. 6 will be described with reference to FIG. FIG. 8 is a flowchart showing an example of a process for selecting one or more optimal medication schedules.

The optimal schedule selection unit 520 sets the index i (i = 1,..., N _sch ) of the candidate schedule to i = 1 (step S802). Next, d (i, j) is the standard number of days of the j (j = 1,..., N _term (i)) th one or more consecutive taking periods included in the specific candidate schedule i. When medication days and R _1, the optimal schedule selection section 520, for each candidate sequence i,
The distance function D (i) represented by is calculated (step S804). Next, if the average of the days d (i, j) of one or more continuous dosing periods j included in a specific candidate schedule i is μ (i) and the variance is {σ (i)} ² , the optimal schedule The selection unit 520 distributes each candidate sequence i.
Is calculated (step S806). Next, the optimal schedule selection unit 520 determines whether the index i of the candidate schedule is smaller than N _sch (step S808). As a result of the determination in step S808, if the index i of the candidate schedule is smaller than N _sch (YES in step S808), the optimal schedule selection unit 520 performs i ← i + 1 processing (the variable “i” has “i + 1”). Means the process of substituting a value (the same applies hereinafter) (step S810), and the process returns to step S804. On the other hand, as a result of the determination in step S808, when the index i of the candidate schedule is N _sch or more (NO in step S808), the optimal schedule selection unit 520 determines from the smaller value of the distance function D (i), One or more optimal schedules are selected from the one or more candidate schedules (step S812). Thus, the average value of the absolute value difference between the standard continuous medication days R ₁ is the number of days with normal dosing cycle for each successive dose period can be selected as the optimum smaller schedule. Next, the optimal schedule selection unit 520 selects one of the one or more optimal schedules selected based on the value of the distance function D (i) from the one with the smaller value of the variance {σ (i)} ^2. Alternatively, a plurality of final candidate schedules are selected (step S814). Thereby, the schedule with few variations between each continuous dosing period can be selected as an optimal one.

As described above, the optimal schedule candidates in the present embodiment, that the number of days in each medication period is not deviated from the standard continuous dosing days R ₁ and a first reference, are not vary as much as possible the length of each successive dose period Is selected as the second criterion. At this time, extending the continuous dosing period by 1 day and shortening it by 1 day are treated as the same (both are determined to be 1).

In the present embodiment, if the value of the distance function D (i) is equal as a result of selection based on the first criterion, the final schedule candidate that makes the value of variance {σ (i)} ² smaller is selected. However, the present invention is not limited to this, and for example, only the first reference may be applied, and a plurality of schedule candidates having the same value of the distance function D (i) may be selected as the final candidates.

Next, the optimal schedule selection unit 520 stores one or more medication schedules selected as the final candidate schedule, the distance function D (i) and the variance {σ (i)} ² corresponding to the final candidate schedule. The data is stored in the user medication record data database 606 of the server 116 or 120 (step S816), and the optimum schedule selection process is terminated.

  Next, scheduling results according to the present embodiment will be described with reference to FIGS. 9 to 12. FIG. 9 shows an example of a dosing schedule that resulted in accelerated withdrawal bleeding before the avoidance period. In the figure, “◯” below the date represents a medication date (scheduled medication date), “×” represents a drug holiday (scheduled drug holiday), and “-” represents an avoidance date. The avoidance date does not indicate “○” indicating that it is a medication day, but the avoidance date is the medication date.

Before the March 5 as shown avoidance period March 15, continuous washout period of the standard continuous washout days R ₂ from February 27 to March 4 is set, hasten withdrawal bleeding The resulting medication schedule is an example.

FIG. 10 shows a dosing schedule that resulted in delaying withdrawal bleeding after the avoidance period. As shown in the figure, after the avoidance period from February 26 to February 29, a continuous withdrawal period was set from March 3 to March 9, which resulted in delaying withdrawal bleeding after the avoidance period. It is a dosing schedule. Incidentally, there is no problem even after (March 1) schedule to start washout avoidance period, small schedule absolute value difference is the selection of a standard continuous medication days R ₁ and continuous medication period by the optimum schedule selecting process As a result, March 1 and March 2 are taken as the medication days, and the continuous medication period is 21 days.

  FIG. 11 shows a medication schedule in which there are a plurality of avoidance periods and these are continuously avoided.

As shown in the figure, there is a first avoidance period from March 5 to March 12, and a second avoidance period from March 18 to April 5, withdrawn before the first avoidance period. The dosing schedule resulted in early bleeding and delayed withdrawal bleeding after the second avoidance period. Here, in this example, since the number of days between the first avoidance period and the second avoidance period is 5 days, which is smaller than the standard consecutive drug holiday days R ₂ = 7 days, these two avoidance periods A continuous drug holiday cannot be set between. Accordingly, the two avoidance periods belong to the same continuous dosing period, and the number of days of the continuous dosing period is 32 days.

FIG. 12 shows another example of a dosing schedule that has a plurality of avoidance periods and avoids them continuously. As shown, there is a first avoidance period from March 7 to March 17 and a second avoidance period from March 25 to April 25, the first avoidance period and the second avoidance period It is a schedule in which a continuous withdrawal period is set between the avoidance period. The continuous medication period is 14 days from February 12 to February 25, 14 days from March 4 to March 17, and 32 days from March 25 to April 25. ing. Here, there is no problem with a schedule in which a continuous withdrawal period is not provided between the first avoidance period and the second avoidance period. However, the absolute schedule between the continuous medication period and the standard continuous medication days R ₁ is determined by the optimal schedule selection process. As a result of selecting a schedule having a small value difference, the schedule is such that a continuous drug holiday period is set between the first avoidance period and the second avoidance period.

  As described above, in the present embodiment, a schedule in which the average value of the absolute value difference between the number of days of the continuous medication period selected by the optimal schedule selection process and the standard continuous medication period is small (and there is little variation between the continuous medication periods. A schedule in which the menstruation is preceded / posted for one or more avoidance periods can be presented to the user.

(6) Display example FIG. 13: is a figure which shows the display example of the calculation result of the oral contraceptive medication scheduling algorithm according to this embodiment.

  As shown in FIG. 14, the user l sends to the user terminal 104-l the previous menstruation date is December 4, the average menstrual cycle is 28 days, the avoidance period is January 12 and January 29. Are input on the initial screen as February 4, February 8, and February 9. In response to the input of the user l, the analysis server 114 or 122 returns a calendar display of the medication schedule to the user terminal 104-1. In the calendar display, the continuous withdrawal period is indicated by a framed schedule, the continuous dose period is indicated by a gray schedule with a frame, and the avoidance period is indicated by a circled schedule. The displayed medication schedule shows that oral contraceptives are started on the third day of menstruation and then taken for 14 days to avoid the January 12 game. Then, according to the medication schedule displayed, the drug was withdrawn for 7 days, causing withdrawal bleeding, taking the drug for 21 days from January 24, training camp from January 29 to February 4, and February 8 and 2 It has been shown to avoid the match on Monday.

  FIG. 14 is a diagram showing a screen display example on the user terminal of the oral contraceptive medication scheduling system according to the present embodiment.

  In the oral contraceptive medication scheduling system according to the present embodiment, when the user l inputs the oral contraceptive medication record to the user terminal 104-1, the schedule and the actual result are displayed, and two or more consecutive days on the scheduled medication date are displayed. When there is no medication, the medication timing is updated. In addition, the oral contraceptive medication scheduling system is configured to register the medication record and physical condition, and display a message recommending a doctor's visit on the user terminal 104-1 when there is a possibility of side effects. Furthermore, the oral contraceptive medication scheduling system is configured to warn the user of the user terminal 104-1 on a daily push notification of the actual medication input on the display screen.

  Each step of the above-described method according to the present invention may be performed by a terminal device such as a computer or a workstation provided with a CPU and a memory. In the above embodiment, it is described that the calculation is performed in the analysis servers 114 and 122 in response to the input of the user l to the user terminal 104-1. It is also possible to download a contraceptive medication scheduling program and perform the calculation at the user terminal 104-1.

  In an embodiment of the present invention, the software program used to execute the above method may be stored in a program storage device such as a digital data storage medium, and these program storage devices Are machine-readable or computer-readable, and these computers or machines encode program instructions as machine-executable programs or computer-executable programs, and the encoded program instructions are the method of the present invention. Some or all of these steps are executed. The program storage device can be, for example, a digital storage, a magnetic storage medium such as a magnetic disk and magnetic tape, a hard drive, or an optically readable digital data storage medium.

  The present invention may be software and / or a combination of software and hardware, for example, an application specific integrated circuit (ASIC), a field programmable gate array (FPGA), It may be implemented using a general purpose computer, or any other hardware equivalent.

  The above description merely provides a disclosure of specific embodiments of the invention and is not intended to limit the invention to only the above embodiments. Accordingly, it is recognized that the present invention is not limited to the embodiments described above, but rather, those skilled in the art can devise alternative embodiments that fall within the scope of the present invention.

100: Scheduling system 102: Analysis center 104: User terminal 106: Medical institution 108: Administrator terminal 110: Communication network 112: Web server 114: Analysis server

Claims (11)

According to at least one avoidance period pre-selected as a period to avoid menstruation, at least one continuous dosing period in which the user takes oral contraceptives continuously, and a day when the user does not take oral contraceptives A scheduling system for setting an oral contraceptive medication schedule comprising at least one continuous drug withdrawal period,
Information on the at least one avoidance period, the number of days in which the user has continuously taken oral contraceptives in the most recent setting date, which is the date for setting the oral contraceptive medication schedule, and the setting date An acquisition unit that acquires the latest drug holiday days indicating the number of days the user has not taken oral contraceptives most recently and the most recent menstrual day;
Based on the information about the avoidance period, the number of days of the latest medication, the number of days of the latest medication and the date of the latest menstrual period, at least one combination of the at least one continuous medication period and the at least one continuous medication period A medication schedule search unit to search;
One or more combinations are selected from the at least one combination in order from the smallest absolute value difference between the at least one continuous dosing period included in the at least one combination and the predetermined standard continuous dosing days An oral contraceptive medication scheduling system including an optimal schedule selection unit. In the oral contraceptive medication scheduling system according to claim 1,
The index of the searched at least one combination is i (i = 1,..., N _sch ), and j (j = 1,..., N _term ) of the at least one continuous dosing period included in the specific combination i. (I)) When the number of days of the first item is d (i, j), the standard number of continuous administration days is R ₁ , and the distance function is D (i), the optimal schedule selection unit
Oral contraceptive medication scheduling system that selects one or a plurality of optimal combinations from the smaller values of the distance function D (i) according to the first criterion of reducing the distance function D (i) represented by . In the oral contraceptive medication scheduling system according to claim 2,
The optimal schedule selection unit selects a plurality of optimal combinations according to the first criterion,
According to the first criterion, according to the second criterion of reducing the variance {σ (i)} ² of the number of days d (i, j) of each of the at least one continuous dosing period included in the selected combination i An oral contraceptive medication scheduling system that selects one or a plurality of combinations as the optimal combination from the plurality of selected optimal combinations having the smallest value of the variance {σ (i)} ² . In the oral contraceptive medication scheduling system according to any one of claims 1 to 3,
The oral contraceptive medication scheduling system, in which the standard continuous medication days is R ₁ = 21. In the oral contraceptive medication scheduling system according to any one of claims 1 to 4,
If there is at least one acceptable number of days between the at least two most recent medication periods in which the user has taken oral contraceptives in succession in the most recent set date, the most recent medication days are: An oral contraceptive medication scheduling system, calculated as the total number of days of the at least two most recent medication periods and an acceptable number of days of the at least one recent medication period. In the oral contraceptive medication scheduling system according to claim 1,
The medication schedule search unit determines a date on which a medication or a drug withdrawal is determined based on a predetermined standard for determining a medication or a medication withdrawal from among the days to be determined for the medication or the medication withdrawal. Or an oral contraceptive medication scheduling system that searches for a schedule that considers all combinations of days when any of the drug withdrawals is not determined. In the oral contraceptive medication scheduling system according to claim 6,
D _min , the minimum number of days of continuous use of oral contraceptives to cause withdrawal bleeding, d _min , the number of standard continuous withdrawal days required to cause and terminate withdrawal bleeding during the continuous withdrawal period Is R ₂ , the medication schedule search unit
(1) The day before the date of the subject of determination of medication or drug withdrawal is the medication date, and the number of days of the latest medication up to the date of subject of judgment of the medication or drug withdrawal is {d _min -1} or less,
(2) The number of days of the latest medication up to the date on which the determination of the medication or drug withdrawal is {d _min -1} or more, and the first day of the avoidance period closest to the reference date is {R Within ₂ -1} days,
(3) The day subject to the determination of the medication or withdrawal belongs to the avoidance period,
In any of the cases, the oral contraceptive medication scheduling system, in which the date on which the determination of the medication or the withdrawal is made is determined as a medication date. In the oral contraceptive medication scheduling system according to claim 6,
When the standard continuous drug holiday days required to cause and terminate withdrawal bleeding during the continuous drug holiday period is R ₂ , the drug schedule search unit is a target for determination of the drug or drug holiday If washout days until the day is less than R _2, a reference to determine the day to be determined該服agent or washout as drug holiday, oral contraceptives taken scheduling system. In the oral contraceptive medication scheduling system according to any one of claims 7 and 8,
The oral contraceptive medication scheduling system, in which the shortest continuous dose is d _min = 14, the standard continuous dose is R ₁ = 21, and the standard continuous dose is R ₂ = 7. According to at least one avoidance period preselected as a period for avoiding menstruation, the computer has at least one continuous dose period in which the user takes oral contraceptives, and the user takes oral contraceptives. An oral contraceptive medication scheduling program for executing an oral contraceptive medication scheduling method for setting an oral contraceptive medication schedule including at least one continuous drug holiday period in which non-medication days are consecutive, the computer comprising an acquisition unit and a medication Acting as an oral contraceptive medication scheduling system including a schedule search unit and an optimal schedule selection unit,
The acquisition unit has information on the at least one avoidance period, and the most recent medication days indicating the number of days that the user has continuously taken oral contraceptives most recently on the set date, which is the date on which the oral contraceptive medication schedule is set. A step of acquiring the most recent drug holiday indicating the number of days that the user has not continuously taken oral contraceptives in the most recent set date, and the most recent menstruation date,
The medication schedule search unit, based on the information on the avoidance period, the most recent medication days, the most recent medication days, and the most recent menstrual day, the at least one continuous medication period and the at least one continuous medication Searching for at least one combination of time periods;
The optimal schedule selection unit selects one of the at least one combination in order from the smallest absolute value difference between the at least one continuous dosing period included in the at least one combination and the predetermined standard continuous dosing days. Or selecting a plurality of combinations. An oral contraceptive scheduling program. In an oral contraceptive medication scheduling system including an acquisition unit, a medication schedule search unit, and an optimal schedule selection unit, the user takes oral contraceptives according to at least one avoidance period pre-selected as a period for avoiding menstruation An oral contraceptive scheduling method for setting an oral contraceptive pill schedule including at least one continuous dosing period on which consecutive days are taken and at least one continuous rest period on which the user does not take oral contraceptives. There,
The acquisition unit has information on the at least one avoidance period, and the most recent medication days indicating the number of days that the user has continuously taken oral contraceptives most recently on the set date, which is the date on which the oral contraceptive medication schedule is set. A step of acquiring the most recent drug holiday indicating the number of days that the user has not continuously taken oral contraceptives in the most recent set date, and the most recent menstruation date,
The medication schedule search unit, based on the information on the avoidance period, the most recent medication days, the most recent medication days, and the most recent menstrual day, the at least one continuous medication period and the at least one continuous medication Searching for at least one combination of time periods;
The optimal schedule selection unit selects one of the at least one combination in order from the smallest absolute value difference between the at least one continuous dosing period included in the at least one combination and the predetermined standard continuous dosing days. Or selecting a plurality of combinations.