JP2017169982A - Flow passage branch tube and blood bag system - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide a flow passage branch tube in which a wrong flow passage is not selected due to a manual mistake, and a blood bag system having the tube.SOLUTION: A flow passage branch tube 1 held by a tool of a separation device for separating blood into predetermined blood components comprises: a body port 2 and plural branch ports 3 and 4 branched from the end of the body port 2. The surface shape of a lower face 1a held by the tool is different from that of an upper face 1b on the face opposite the lower face 1a.SELECTED DRAWING: Figure 1

Description

  The present invention relates to a flow path branch pipe that is held by a jig of an apparatus and used to branch a flow path of a medical liquid, and a blood bag system having the flow path branch pipe. In particular, the present invention is used for blood component separation operations in blood product production.

  Conventionally, a blood bag system described in Patent Document 1 is used for manufacturing a blood product. The blood bag system described in Patent Document 1 stores a first bag for storing blood from which unnecessary substances such as white blood cells have been removed, and a second for storing plasma separated by centrifugation from the blood stored in the first bag. A bag, a third bag in which a drug solution to be added to the concentrated red blood cells separated by centrifugation from the blood stored in the first bag is stored in advance, and a first tube that transfers plasma from the first bag to the second bag; And a second tube for transferring the chemical solution from the third bag to the first bag.

  In the blood bag system, a three-way joint is used as a flow path branch pipe. Then, by connecting a three-way joint in the middle of the first tube, and connecting the upstream first tube, the downstream first tube, and the second tube to the three-way joint, the downstream first that becomes the plasma flow path. The tube and the second tube serving as the chemical liquid flow path are branched by a three-way joint.

  On the other hand, in the blood component separation operation using the blood bag system, the operator first confirms the selection of the first tube and the second tube while appropriately checking the selection of the first tube and the second tube using the manual clamp (Kochel). Has controlled the occlusion / opening. In recent years, automatic separation devices such as those described in Patent Document 1 have become widespread, and tube clogging / opening is generally controlled by an automatic clamp and a sensor.

  The automatic separation apparatus includes a first installation chamber in which a first bag is installed, a second installation chamber in which a second bag is installed, a third installation chamber in which a third bag is installed, It has the 1st and 2nd clamp which controls opening, and the 3rd clamp which controls obstruction | occlusion / opening of a 2nd tube.

Even in such an automatic separation device, when setting the blood bag system, the operator
It is necessary to make sure that the correct tube is set in the clamp. If the operator sets the wrong tube in the clamp and selects the wrong flow path, the plasma in the first bag separated by centrifugation is transferred to the drug solution bag instead of the storage bag, and the separation operation is repeated from the centrifugation. You will have to start over. As a result, the manufactured blood product is impaired.

  In order to prevent such an incorrect flow channel selection due to an operator's tube setting mistake, the automatic separation device is provided with a jig having a groove portion that matches the outer shape of the three-way joint, and the three-way joint is fitted into the groove portion of this jig. It was.

JP 2008-188230 A

  However, a soft resin tube made of polyvinyl chloride resin or the like is used for the three-way joint so that the bag or the like is not damaged when the blood bag system is centrifuged. Therefore, even if the operator mistakes the fitting direction of the three-way joint that is a flow branch pipe to the jig, the problem is that the flow branch pipe is fitted to the jig and the wrong flow path is selected. Still remained.

  Accordingly, the present invention has been developed to solve such problems, and the problem is to provide a flow channel branch pipe that does not cause a flow channel selection error due to human error and a blood bag system having the same. There is.

  In order to solve the above problems, a flow channel branch tube according to the present invention is a flow channel branch tube held by a jig of a separation device that separates blood into predetermined blood components, and includes a main body port and the main body port. And having a plurality of branch ports branched from the end of the bottom surface, the surface shape of the lower surface held by the jig is different from the surface shape of the upper surface opposite to the lower surface.

  According to the flow path branch pipe according to the present invention, since the surface shape of the lower surface and the surface shape of the upper surface are different, even if an attempt is made to fit the flow path branch pipe to the jig in the wrong direction due to human error, The path branch pipe does not fit into the jig, and the flow path branch pipe is not held by the jig. Alternatively, the operator can recognize that the fitting direction of the channel branch pipe is wrong.

  A flow path branch pipe according to the present invention is a flow path branch pipe that is held by a jig of a separation device that separates blood into predetermined blood components, and includes a main body port and a plurality of branches branched from an end of the main body port. The shape of at least one of the branch ports is different from the shape of the other branch ports.

  According to the flow path branch pipe according to the present invention, the shape of at least one branch port is different from the shape of the other branch ports, so that the flow path branch pipe is fitted to the jig in the wrong direction due to human error. Even if it tries, the flow path branch pipe does not fit into the jig, and the flow path branch pipe is not held by the jig. Alternatively, the operator can recognize that the fitting direction of the channel branch pipe is wrong.

  In the flow channel branch pipe according to the present invention, at least one of the plurality of branch ports has an angle formed between an axis of the main body port and an axis of the main body port, and an axis of the other branch port and an axis of the main body port are It is preferable that the angle is different.

  Because the angle of the branch port is different in this way, even when trying to fit the flow branch pipe to the jig in the wrong direction due to human error, the flow branch pipe becomes more difficult to fit into the jig. The branch pipe is not held by a jig. Or it becomes easier for the operator to recognize that the fitting direction of the flow path branch pipe is wrong.

  The blood bag system according to the present invention is a blood bag system having the flow path branching tube, and includes a storage bag for storing blood and a blood component separated from the blood stored in the storage bag by centrifugation. A storage bag for storing a portion, a medical solution bag for storing a chemical solution to be added to a part of blood components separated by centrifugation from the blood stored in the storage bag, and one end through a first sealing member The other end of the first tube is connected to the storage bag, the other end is connected to the storage bag, the one end is connected to the flow branch pipe connected to the middle of the first tube, and the other end is sealed to the second seal. And a second tube connected to the drug solution bag via a stop member.

  According to the blood bag system of the present invention, when holding the blood bag system in the apparatus, by having the flow path branch pipe, the flow path branch pipe is fitted to the jig in the wrong direction due to human error. Even so, the channel branch pipe does not fit into the jig. Alternatively, the operator can recognize that the fitting direction of the channel branch pipe is wrong.

  According to the flow path branch pipe and the blood bag system having the same according to the present invention, there is no error in selecting the flow path due to human error. As a result, when blood component separation is performed by holding the flow path branch pipe and the blood bag system having the same in the separation device, a separation operation error does not occur and the manufactured blood product is not impaired.

The flow-path branch pipe which concerns on 1st Embodiment of this invention is shown, (a) is a perspective view, (b) is the top view seen planarly from the upper surface side, (c) is a front view. The modification of the flow-path branch pipe of 1st Embodiment is shown, (a) is a side view, (b) is the top view seen planarly from the upper surface side. The modification of the flow-path branch pipe of 1st Embodiment is shown, (a) is a side view, (b) is the top view seen planarly from the upper surface side. (A), (b) is the top view which planarly viewed from the upper surface side which shows the flow-path branch pipe which concerns on 2nd Embodiment of this invention. It is the top view seen from the upper surface side which shows the modification of the flow-path branch pipe of 2nd Embodiment. It is a top view of the jig holding the flow path branch pipe of FIG. It is a top view of the jig holding the flow path branch pipe of FIG. 2 or FIG. FIG. 5A is a plan view of a jig that holds the flow path branch pipe of FIG. 4A, and FIG. 5B is a plan view of the jig that holds the flow path branch pipe of FIG. It is a top view of the jig holding the flow path branch pipe of FIG. It is the schematic which shows the structure of the blood bag system which concerns on embodiment of this invention. It is the schematic which shows the structure of the separation apparatus using the blood bag system of FIG. It is the schematic which shows a part of structure of the centrifuge transfer apparatus using the blood bag system of FIG.

  The flow path branch pipe according to the present invention is held by a jig of a separation device that separates blood into predetermined blood components, and examples of the blood component include concentrated red blood cells and platelets.

1st Embodiment of the flow-path branch pipe which concerns on this invention is described with reference to drawings.
As shown in FIGS. 1 to 3, the flow branch pipe 1 is held by a jig 10 (see FIGS. 11 and 12) of the apparatus and is branched from a main body port 2 and an end of the main body port 2. It has a so-called upper and lower non-target structure in which the surface shape of the lower surface 1a held by the jig 10 is different from the surface shape of the upper surface 1b opposite to the lower surface 1a. The vertically asymmetric structure means that the surface shape of the lower surface 1a is different from the inverted shape when the surface shape of the upper surface 1b is rotated around the body port 2. The main body port 2 and the plurality of branch ports 3 and 4 are soft resin tubular bodies. 1 to 3 show the two branch ports 3 and 4 as the branch ports of the flow path branch pipe 1, but the number of branch ports may be three or more.

  The main body port 2 means a port through which medical liquid such as blood flows first, and is a port on the side of the containing bag 22 in the blood bag system 21 used for blood component separation shown in FIG. The branch port 3 is a port on the storage bag 23 side, and the branch port 4 is a port on the chemical solution bag 24 side. The branch port 3 may be a port on the chemical solution bag 24 side, and the branch port 4 may be a port on the storage bag 23 side.

  In the main body port 2 and a plurality of branch ports (for example, the branch ports 3 and 4), a lumen 6 is connected to a tube (see the first tube 25 and the second tube 26 in FIG. 10) and serves as a medical fluid flow path. The cross-sectional shape is circular, but the outer cross-sectional shape may be other than a circular shape such as a rectangular shape. Further, the outer cross-sectional shape, outer diameter, and length of the main body port 2 and the plurality of branch ports (for example, the branch ports 3 and 4) are not particularly limited, and may be the same or different. Furthermore, the angle formed between the axis of each of the plurality of branch ports (for example, the branch ports 3 and 4) and the axis of the main body port 2 is not particularly limited, and may be the same or different. Note that the angle formed by the axis of at least one of the plurality of branch ports (for example, the branch port 3) and the axis of the main body port 2 is the axis of the other branch port (for example, the branch port 4) and the axis of the main body port 2. It is preferable that the angle is different from the angle formed by. Thereby, the attachment mistake of the fitting direction to the jig 10 of the flow path branch pipe 1 is prevented.

  1A to 1C has a vertically asymmetric structure, a plane formed by a main body port 2 and one branch port (for example, a branch port 3), and a main body port 2 And a plane formed by another one branch port (for example, the branch port 4) are different from each other in a three-dimensional asymmetry.

  Specifically, the main body port 2 extends linearly in the axial direction. The branch port 3 is inclined at a predetermined angle with respect to the axis of the main body port 2 in plan view, extends in a direction different from the branch port 4, and extends in the same direction as the axis of the main body port 2 in side view. The branch port 4 extends in the same direction as the axis of the main body port 2 with respect to the axis of the main body port 2 in a plan view, and inclines at a predetermined angle in a side view and extends in a direction different from the branch port 3.

  When the flow path branch pipe 1 is fitted to the jig 10 shown in FIG. 6 on the lower surface 1 a side, the main body port 2 is held in the groove portion 12 formed in the jig main body 11, and the branch port 3 is held in the groove portion 13. Is done. However, when the flow path branch pipe 1 is fitted to the jig 10 on the upper surface 1 b side, the branch port 4 becomes a three-dimensional obstacle and is not held by the jig 10. Thereby, the mistake of the flow path selection by the mistake of the fitting direction of the flow path branch pipe 1 to the jig 10 is prevented. The same applies to the case where the branch ports 3 and 4 are reversed on the left and right, and the case where there are three or more branch ports.

  2 (a) and 2 (b) has a vertically asymmetric structure in which the main body port 2 and at least one port of the plurality of branch ports (for example, the branch ports 3 and 4) are on the upper surface 1b side. This is achieved by forming the convex portion 5 on the surface. The main body port 2 and the plurality of branch ports (for example, the branch ports 3 and 4) are formed on the same plane. Further, although not shown, the convex portion 5 may be formed continuously in the axial direction of the port. The width D2 and the height h1 of the convex portion 5 are not particularly limited, but are preferably D2 ≧ 0.5D1 and h1 ≧ 0.5D1 with respect to the port diameter, for example, the port diameter D1 of the main body port 2. The cross-sectional shape of the convex portion 5 is not particularly limited, and may be a triangular shape other than a semicircular shape.

  When the flow path branch pipe 1 is fitted to the jig 10 shown in FIG. 7 on the lower surface 1 a side, the main body port 2 is held in the groove portion 12 formed in the jig main body 11, and the branch port 3 is held in the groove portion 13. The branch port 4 is held in the groove portion 14. However, when the flow path branch pipe 1 is fitted to the jig 10 on the upper surface 1 b side, the convex portion 5 becomes an obstacle and is not held by the jig 10. Thereby, the mistake of the flow path selection by the mistake of the fitting direction of the flow path branch pipe 1 to the jig 10 is prevented. The same applies to the case where the branch ports 3 and 4 are reversed on the left and right, and the case where there are three or more branch ports.

  3 (a) and 3 (b) has a vertically asymmetric structure in which at least one of a plurality of branch ports (for example, the branch ports 3 and 4) is curved toward the upper surface 1b. This is achieved by using an upright structure. The height h2 on the upper surface 1b side of the standing branch port (for example, the branch ports 3 and 4) is not particularly limited, but h2 ≧ 0.5D1 with respect to the port diameter, for example, the port diameter D1 of the main body port 2 Is preferred.

  When the flow path branch pipe 1 is fitted to the jig 10 shown in FIG. 7 on the lower surface 1a side, the main body port 2 is held in the groove portion 12 formed in the jig main body 11, and a part of the branch port 3 is a groove portion. 13 and a part of the branch port 4 is held in the groove portion 14. However, when the flow path branch pipe 1 is fitted to the jig 10 on the upper surface 1 b side, the branch port 3 and the branch port 4 are obstructed and are not held by the jig 10. Thereby, the mistake of the flow path selection by the mistake of the fitting direction of the flow path branch pipe 1 to the jig 10 is prevented. The same applies to the case where the branch ports 3 and 4 are reversed on the left and right, and the case where there are three or more branch ports.

A second embodiment of a channel branch pipe according to the present invention will be described with reference to the drawings.
As shown in FIGS. 4 (a), 4 (b), and 5, the flow path branch pipe 1 is held by a jig 10 (see FIGS. 11 and 12) of the apparatus. A plurality of branch ports (for example, branch ports 3 and 4) branched from the unit, and the outer shape of at least one of the plurality of branch ports (for example, branch port 3) is different from other branch ports (for example, A plurality of so-called branch ports (for example, the branch ports 3 and 4), which are different from the outer shape of the branch port 4), have a structure that is not subject to the left and right of the main body port 2. The main body port 2 and the plurality of branch ports (for example, the branch ports 3 and 4) are formed on the same plane. The main body port 2 and the plurality of branch ports (for example, the branch ports 3 and 4) are tubular bodies made of a soft resin. 4 (a), (b), and FIG. 5, two branch ports 3 and 4 are shown as branch ports of the flow path branch pipe 1. However, the number of branch ports may be three or more.

  The main body port 2 means a port through which medical liquid such as blood flows first, and is a port on the side of the containing bag 22 in the blood bag system 21 used for blood component separation shown in FIG. The branch port 3 is a port on the storage bag 23 side, and the branch port 4 is a port on the chemical solution bag 24 side. The branch port 3 may be a port on the chemical solution bag 24 side, and the branch port 4 may be a port on the storage bag 23 side.

  In the main body port 2 and a plurality of branch ports (for example, the branch ports 3 and 4), a lumen 6 is connected to a tube (see the first tube 25 and the second tube 26 in FIG. 10) and serves as a medical fluid flow path. The cross-sectional shape is circular, but the outer cross-sectional shape may be other than a circular shape such as a rectangular shape. Further, the outer cross-sectional shape, outer diameter, and length of the main body port 2 and the plurality of branch ports (for example, the branch ports 3 and 4) are not particularly limited, and may be the same or different. Furthermore, the angle formed between the axis of each of the plurality of branch ports (for example, the branch ports 3 and 4) and the axis of the main body port 2 is not particularly limited, and may be the same or different. Note that the angle formed by the axis of at least one of the plurality of branch ports (for example, the branch port 3) and the axis of the main body port 2 is the axis of the other branch port (for example, the branch port 4) and the axis of the main body port 2. It is preferable that the angle is different from the angle formed by. Thereby, the attachment mistake of the fitting direction to the jig 10 of the flow path branch pipe 1 is prevented. Further, the axial direction of each of the plurality of branch ports (for example, the branch ports 3 and 4) is not particularly limited, and may be the same or different.

  The flow path branch pipe 1 shown in FIG. 4A has a left-right asymmetric structure, and the length of at least one of a plurality of branch ports (for example, the branch port 3) is different from that of another branch port (for example, the branch port 4). ) And a different structure. The length of the plurality of branch ports (for example, the branch ports 3 and 4) is not particularly limited, but the outer diameter L2 of at least one of the plurality of branch ports (for example, the branch port 3) is different from that of the other branch. It is preferable that L2 ≦ 0.5L1 with respect to the length L1 of the port (for example, the branch port 4). Although not shown, L1 ≦ 0.5L2 may be satisfied.

  When the flow path branch pipe 1 is fitted to the jig 10 shown in FIG. 8A on the lower surface side, the main body port 2 is held in the groove portion 12 formed in the jig main body 11, and the branch port 3 is held in the groove portion 13. The branch port 4 is held in the groove portion 14. However, when the flow path branch pipe 1 is fitted to the jig 10 on the upper surface side, the stepped portion 13 a formed in the groove portion 13 becomes an obstacle and the branch port 4 is not held by the jig 10. In addition, the space | interval of the level | step-difference part 13a is a distance substantially the same as the diameter of the tube connected to the branch port 3. FIG. Although not shown, even when the length of the branch port 3 is long, the stepped portion formed in the groove portion 14 becomes an obstacle and the branch port 3 is not held by the jig 10. Thereby, the mistake of the flow path selection by the mistake of the fitting direction of the flow path branch pipe 1 to the jig 10 is prevented. The same applies when there are three or more branch ports.

  The flow branch pipe 1 shown in FIG. 4B has an asymmetric structure, and the outer diameter of at least one of the plurality of branch ports (for example, the branch port 3) is different from that of other branch ports (for example, the branch port 4). ) To achieve a structure different from the outer diameter. The outer diameter of the plurality of branch ports (for example, the branch ports 3 and 4) is not particularly limited, but the outer diameter D3 of at least one of the plurality of branch ports (for example, the branch port 3) is the other branch. It is preferable that D3 ≦ 0.5D4 with respect to the outer diameter D4 of the port (for example, the branch port 4). Although not shown, D4 ≦ 0.5D3 may be satisfied.

  When the flow path branch pipe 1 is fitted to the jig 10 shown in FIG. 8B on the lower surface side, the main body port 2 is held in the groove portion 12 formed in the jig main body 11, and the branch port 3 is held in the groove portion 13. The branch port 4 is held in the groove portion 14. However, when the flow path branch pipe 1 is fitted to the jig 10 on the upper surface side, the branch port 4 becomes an obstacle and is not held by the jig 10. Although not shown, even when the branch port 3 has a large diameter, the branch port 3 becomes an obstacle and is not held by the jig 10. Thereby, the mistake of the flow path selection by the mistake of the fitting direction of the flow path branch pipe 1 to the jig 10 is prevented. The same applies when there are three or more branch ports.

  The channel branch pipe 1 shown in FIG. 5 has an asymmetric structure in which the outer shape of at least one of a plurality of branch ports (for example, the branch port 3) is the outer shape of another branch port (for example, the branch port 4). This is achieved by making the structure different from the shape. Specifically, the outer shape of the branch port 4 is a straight line in the axial direction, and the outer shape of the branch port 3 is a shape such as a curve other than the straight line in the axial direction. Although not shown, the branch port 3 may be a straight line, and the branch port 4 may be a curve. The external shape other than the straight line is not limited to a curved line, and may be a bent line or the like.

  When the flow path branch pipe 1 is fitted to the jig 10 shown in FIG. 9 on the lower surface side, the main body port 2 is held in the groove portion 12 formed in the jig main body 11, and the branch port 3 is held in the groove portion 13. The branch port 4 is held in the groove portion 14. However, when the flow path branch pipe 1 is fitted to the jig 10 on the upper surface side, the branch port 3 becomes an obstacle and is not held by the jig 10. Although not shown, even when the branch port 4 is curved, the branch port 4 becomes an obstacle and is not held by the jig 10. Thereby, the mistake of the flow path selection by the mistake of the fitting direction of the flow path branch pipe 1 to the jig 10 is prevented. The same applies when there are three or more branch ports.

Next, a blood bag system according to the present invention will be described with reference to the drawings, taking as an example a blood bag system used for blood component separation having the flow path branch pipe.
As shown in FIG. 10, the blood bag system 21 includes a storage bag 22, a storage bag 23, a chemical solution bag 24, a first tube 25, a second tube 26, a first sealing member 27, and a second. And a sealing member 28. The blood bag system 21 has the flow path branch pipe 1 at the connection of the second tube 26. Since the flow path branch pipe 1 is as described above, the description thereof is omitted. Each configuration will be described below.

The storage bag 22, the storage bag 23, and the chemical solution bag 24 are bags configured in a bag shape by stacking sheet materials made of a soft resin such as polyvinyl chloride and fusing or bonding the peripheral edges thereof.
The storage bag 22 is a bag in which a blood collection tube 29 made of a soft resin is connected to an end portion thereof, and blood is collected through the liquid collection tube 29. Here, the blood is whole blood or blood obtained by removing unnecessary substances such as white blood cells and platelets from whole blood. The storage bag 22 is a bag for storing a part of blood components obtained by centrifuging the stored blood, such as concentrated red blood cells. The storage bag 23 is a bag for storing a part of blood components obtained by centrifugation, such as plasma. The drug solution bag 24 is a bag that previously stores a drug solution M to be added to a part of blood components obtained by centrifugation, for example, a red blood cell storage solution, a platelet storage solution, and the like.

  The first tube 25 and the second tube 26 are made of a soft resin tube. Examples of the soft resin constituting the tube include polyvinyl chloride. The first tube 25 has one end connected to the storage bag 22 via the first sealing member 27 and the other end connected to the storage bag 23. The tube transfers plasma or the like from the storage bag 22 to the storage bag 23. (Plasma flow path). One end of the second tube 26 is connected to the flow branch pipe 1 made of a soft resin that is connected to the middle of the first tube 25, and the other end is connected to the chemical solution bag 24 via the second sealing member 28. This is a tube (medical solution flow path) for transferring a chemical solution such as a red blood cell preservation solution from the chemical solution bag 24 to the containing bag 22. The first sealing member 27 and the second sealing member 28 are hard resin tubular bodies configured to open the flow path by breaking the fragile portion. Note that a chemical solution such as a red blood cell preservation solution is added to the concentrated red blood cells of the storage bag 22 via the second tube 26, the upstream portion of the flow path branch tube 1 and the first tube 25, and the first sealing member 27. .

  Since the blood bag system 21 has the above-described channel branch pipe 1, the jig 10 of the channel branch pipe 1 is held as described above when held in the separation device 41 and the centrifugal transfer device 51 via the jig 10. If the fitting direction is wrong, the jig 10 is not held. Therefore, in the blood bag system 21, an incorrect flow path selection due to human error does not occur.

  In addition to the above-described configuration, the blood bag system 21 according to the present invention, as described in JP 2013-203659 A, serves as a blood collection unit that collects blood from a donor on the upstream side of the collection tube 29. You may have a blood processing filter etc. as a pre-processing part which removes an unnecessary thing from the extract | collected blood, such as a blood collection needle, an initial blood bag, and a blood collection bag.

Next, a method for using the flow path branch pipe and the blood bag system according to the present invention will be described with reference to the drawings. Refer to FIG. 10 for the structure of the blood bag system.
First, a case where the blood component separated by centrifugation is used in a separation device that automatically transfers it to a bag will be described.

  As shown in FIG. 11, the separation device 41 includes a first installation chamber 42 in which the storage bag 22 is pressure-controlled by the first pressing portion 43 and a chemical solution bag 24 added by the second pressing portion 45. A first installation chamber 44 that is installed to be pressure-controlled, a third installation chamber 46 in which the storage bag 23 is installed, and a first bag that connects the storage bag 22, the storage bag 23, and the chemical solution bag 24. The first and third clamps 47 to 49 that respectively close and open the tube 25 and the second tube 26 independently. The separation device 41 includes a jig 10 that holds the flow path branch pipe 1.

In the separation device 41, the following (1) to (4) are automatically performed to produce a concentrated red blood cell preparation in the storage bag 22 and a plasma preparation in the storage bag 23.
(1) After the blood bag system 21 after blood collection is centrifuged, the storage bag 22 is placed in the first installation chamber 42, the storage bag 23 is placed in the third installation chamber 46, and the drug solution bag 24 is placed in the second installation chamber 44. set. At this time, the flow path branch pipe 1 is held by the jig 10. As described above, if the fitting direction of the flow path branch pipe 1 to the jig 10 is wrong, the flow path branch pipe 1 is not held by the jig 10. As a result, in the following (2) to (4), the first to third clamps 47 to 49 do not close / open the wrong first and second tubes. Therefore, the wrong flow path selection due to human error does not occur. In the storage bag 22, the collected blood is separated into three layers, an air layer in the upper layer, a plasma layer in the middle layer, and a concentrated red blood cell layer in the lower layer. Moreover, about the 1st, 2nd sealing members 27 and 28, it is set as the state which fractured | ruptured the weak part and the flow path opened.

(2) The first clamp 47 is in the closed state, the second and third clamps 48 and 49 are in the open state, the storage bag 22 is pressed by the first pressing portion 43, and the upper layer air is the first tube 25 and the flow path is branched. It is transferred to the chemical solution bag 24 through the tube 1 and the second tube 26. When the interface with the plasma layer is detected by an optical sensor (not shown) or the like, the pressing of the first pressing portion 43 is stopped.

(3) The second clamp 48 is in the closed state, the first and third clamps 47 and 49 are in the open state, the pressing by the first pressing portion 43 is resumed, and the middle layer plasma flows from the storage bag 22 into the first tube 25 and the flow. It is transferred to the storage bag 23 through the road branch pipe 1. When the interface with the concentrated red blood cell layer is detected by an optical sensor (not shown) or the like, the pressing of the first pressing portion 43 is stopped.

(4) The first clamp 47 is closed, the second and third clamps 48 and 49 are opened, the drug solution bag 24 is pressed by the second pressing portion 45, and the drug solution (erythrocyte storage solution) M in the drug solution bag 24 is discharged. It is transferred to the concentrated red blood cell layer remaining in the storage bag 22 through the second tube 26, the flow branch pipe 1 and the first tube 25.

  Next, a description will be given of a case where the centrifugal component is used for a centrifugal transfer device that automatically transfers blood components to a bag while performing a centrifugal operation.

  As shown in FIG. 12, the centrifugal transfer device 51 includes a centrifugal drum 52 partitioned into a plurality of units 53. Each unit 53 has a first bag pocket 54 into which the accommodation bag 22 is inserted, and a storage. The second bag pocket 55 into which the bag 23 and the chemical solution bag 24 are inserted, the pressing portion 56 that can be advanced and retracted in the rotational radial direction from the side surface side of the first bag pocket 54, and the first and second tubes 25 that connect the bags. , 26 are respectively closed and opened independently, and first and second clamps (not shown). The centrifugal transfer device 51 includes a jig 10 that holds the flow path branch pipe 1.

  In the centrifugal separation transfer device 51, when the blood bag system after blood collection is set in the unit 53, the flow path branch pipe 1 is held by the jig 10, the accommodation bag 22 is installed in the first bag pocket 54, and the chemical solution bag 24. The storage bag 23 is installed in the second bag pocket 55. In addition, about the 1st, 2nd sealing members 27 and 28, it is set as the state which fractured | ruptured the weak part and opened the flow path. Here, the flow path branch pipe 1 is not held by the jig 10 when the fitting direction to the jig 10 is wrong as described above. As a result, the first and second clamps (not shown) do not close / open the wrong first and second tubes 25 and 26. Therefore, the wrong flow path selection due to human error does not occur.

  Next, in the centrifugal separation transfer device 51, when the centrifugal drum 52 is rotated and a centrifugal force is applied to the storage bag 22, the blood in the storage bag 22 is concentrated red blood cell layer, plasma from the outside in the rotational radius direction due to the specific gravity difference. The layers are separated in the order of the air layer. And while rotating the centrifugal drum 52, the 1st, 2nd clamp and the press part 56 which are not shown in figure are controlled, and the same operation as said (2)-(4) is performed automatically, The accommodation bag 22 A concentrated red blood cell preparation and a plasma preparation are produced in the storage bag 23.

DESCRIPTION OF SYMBOLS 1 Channel branch pipe 1a Lower surface 1b Upper surface 2 Main body port 3, 4 Branch port 10 Jig 21 Blood bag system 22 Storage bag 23 Storage bag 24 Chemical solution bag 25 1st tube 26 2nd tube 27 1st sealing member 28 2nd sealing Stop member

Claims (4)

A flow path branch pipe held by a jig of a separation device for separating blood into predetermined blood components,
The body port,
A plurality of branch ports branched from the end of the main body port,
The flow path branch pipe, wherein a surface shape of a lower surface held by the jig is different from a surface shape of an upper surface opposite to the lower surface. A flow path branch pipe held by a jig of a separation device for separating blood into predetermined blood components,
The body port,
A plurality of branch ports branched from the end of the main body port,
A flow channel branch pipe, wherein the shape of at least one of the branch ports is different from the shape of other branch ports.   The angle formed between the axis of at least one of the plurality of branch ports and the axis of the main body tube is different from the angle formed between the axis of another branch port and the axis of the main body tube. Or the flow-path branch pipe of Claim 2. A blood bag system having the flow path branch pipe according to any one of claims 1 to 3,
A storage bag for storing blood;
A storage bag for storing a part of blood components separated by centrifugation from the blood stored in the storage bag;
A medicinal solution bag in which a medicinal solution to be added to a part of the blood component separated by centrifugation from the blood contained in the containing bag is stored in advance;
A first tube having one end connected to the storage bag via a first sealing member and the other end connected to the storage bag;
One end is connected to the flow path branch pipe connected in the middle of the first tube, and the other end has a second tube connected to the chemical solution bag via a second sealing member. A blood bag system characterized by.

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