JP2017056980A - Freezing storage container, label for freezing storage container, and method of manufacturing the same - Google Patents

Abstract

PROBLEM TO BE SOLVED: To prevent separation of a label stuck on a freezing storage container, enable the use of the freezing storage container in a field requiring a higher-level cleanliness factor than ever, and make a manufacturing cost of the freezing storage container lower than ever.SOLUTION: A freezing storage container 100 includes a pressure-sensitive adhesive label 20, and a container 10 on which the pressure-sensitive adhesive label 20 is to be stuck. The pressure-sensitive adhesive label 20 comprises a first part 23 which surrounds the container 10 and which is to be stuck on an outer surface 10a of the container 10, and second parts 24 and 24 which are extended from both ends of the first part 23.SELECTED DRAWING: Figure 2

Description

  The present invention relates to a cryopreservation container for freezing and storing contents, a label for a cryopreservation container, and a method for producing the same.

  Conventionally, for example, plastic that adhesive labels affixed to the outer surface of plastic containers such as blood bags and infusion bags are not easily removed due to the effects of water caused by cryogenic temperature or condensation during cryopreservation Containers are known (see Patent Document 1 below).

  The plastic bag for cryopreservation described in Patent Document 1 is formed by sticking an adhesive label on a fiber sheet thermally welded to the outer surface of the cryopreservation plastic. The fiber sheet is made of plastic fiber or paper using a thermoplastic resin compatible with the material of the cryopreservation plastic bag. The fiber sheet made of paper is obtained by coating one or both sides with a thermoplastic resin that is compatible with the material of the cryopreservation plastic bag.

  In Patent Document 1, since the fiber sheet is chemically bonded to the plastic container, it cannot be easily peeled off in moisture or liquid nitrogen. When the adhesive label is attached to the fiber sheet, the adhesive layer of the adhesive label becomes the fiber sheet. It is described that it can be stuck to the surface of a plastic container without being feared of being easily peeled off in moisture or liquid nitrogen.

Japanese Patent No. 3301074

  Such a cryopreservation container can be used, for example, as a container for stably storing contents such as blood and infusion for a long period of time. However, the conventional plastic bag for cryopreservation needs to thermally weld the fiber sheet to the outer surface of the container. Such a fiber sheet may be a source of dust generation, and may not be used in the field of cellular medicine such as regenerative medicine, cell-containing medicine, and infertility treatment that require high cleanliness. In addition, the manufacturing cost may increase due to the material cost and the complexity of the manufacturing process.

  The present invention has been made in view of the above problems, can prevent the peeling of the label, can be used in a field that requires a higher degree of cleanliness than before, and has a lower manufacturing cost than before. It is an object of the present invention to provide a cryopreservation container, a label for a cryopreservation container, and a manufacturing method thereof that can be reduced.

  In order to achieve the above object, the cryopreservation container of the present invention is a cryopreservation container comprising a label having a base material layer and an adhesive layer, and a container to which the label is attached. A first portion that surrounds the container and is affixed to the outer surface of the container; and a second portion that extends from both ends or one end of the first portion, the second portions at both ends of the first portion; Alternatively, the second portion at one end of the first portion and the other end of the first portion are joined.

  In the cryopreservation container of the present invention, the label includes the first portion and a pair of the second portions extending from both ends of the first portion, and the pair of the first portion at both ends of the first portion. The second parts may be joined to each other.

  The cryopreservation container of the present invention may include a pair of labels facing each other. The pair of labels includes a pair of the first portions facing each other and two pairs of the second portions extending from both ends of the pair of the first portions and facing each other. The two pairs of the second portions at both ends may be joined to each other.

  In the above case, it is preferable that the second portions of the label are joined by the adhesive layers facing each other.

  In the cryopreservation container of the present invention, the label has the first part and the second part extending from one end of the first part, and the second part at one end of the first part. And the other end of the first portion may be joined.

  In this case, the adhesive layer of the second part may be bonded to the surface of the base material layer of the first part.

  Furthermore, in this case, the surface of the base material layer of the first portion has an arithmetic average roughness Ra of not more than the thickness of the adhesive layer and not less than 0.04 times the thickness of the adhesive layer. The surface area ratio is preferably 5 or more.

  Furthermore, in this case, the thickness of the adhesive layer of the second portion is preferably 10 μm or more.

  The label for a cryopreservation container of the present invention is a label for a cryopreservation container provided with a base material layer and an adhesive layer, and the surface of the base material layer has an arithmetic average roughness Ra equal to or less than the thickness of the adhesive layer. And it is 0.04 times or more of the thickness of the said adhesion layer, and ratio of the surface area with respect to a unit flat area is 5 or more, It is characterized by the above-mentioned.

  The method for producing a pressure-sensitive adhesive label for a cryopreservation container according to the present invention is a method for producing a label for a cryopreservation container having a base material layer and a pressure-sensitive adhesive layer, and has an average particle diameter equal to or smaller than the thickness of the pressure-sensitive adhesive layer in a mold. And a concave / convex transfer step for transferring the surface shape of the concave / convex region of the molding die to the surface of the base material layer. The surface of the subsequent base material layer has an arithmetic average roughness Ra of not more than the thickness of the adhesive layer and not less than 0.04 times the thickness of the adhesive layer, and the ratio of the surface area to the unit plane area is not less than 5 It is characterized by being.

  According to the cryopreservation container, the label for the cryopreservation container of the present invention, and the manufacturing method thereof, it is possible to prevent the label attached to the outer surface of the container from being peeled off, and in a field where higher cleanliness is required than before. Can be used, and the manufacturing cost can be reduced as compared with the prior art.

The perspective view before label sticking of the cryopreservation container which concerns on Embodiment 1 of this invention. The perspective view after label sticking of the cryopreservation container shown to FIG. 1A. Sectional drawing which follows the II-II line of the cryopreservation container shown to FIG. 1B. The perspective view before label sticking of the cryopreservation container which concerns on Embodiment 2 of this invention. The perspective view after label sticking of the cryopreservation container shown to FIG. 3A. Sectional drawing which follows the IV-IV line of the cryopreservation container shown to FIG. 3B. The perspective view before label sticking of the cryopreservation container which concerns on Embodiment 3 of this invention. The perspective view after label sticking of the cryopreservation container shown to FIG. 5A. Sectional drawing which follows the VI-VI line of the cryopreservation container shown to FIG. 5B. Sectional drawing which follows the VII-VII line of the cryopreservation container shown in FIG. The flowchart of the manufacturing method of the label for cryopreservation containers shown in FIG.

  Hereinafter, embodiments of a cryopreservation container, a label for a cryopreservation container, and a manufacturing method thereof according to the present invention will be described in detail with reference to the drawings.

[Embodiment 1]
FIG. 1A is a perspective view before a label 20 is attached to the container 10 of the cryopreservation container 100 according to Embodiment 1 of the present invention. FIG. 1B is a perspective view after the label 20 is attached to the container 10 of the cryopreservation container 100 shown in FIG. 1A. 2 is a cross-sectional view of the cryopreservation container shown in FIG. 1B taken along line II-II.

  The cryopreservation container 100 of this embodiment can be used as a container for stably cryopreserving cells and the like for a long period of time in the field of cell medicine such as regenerative medicine, cell-containing pharmaceuticals, and infertility treatment. The cryopreservation container 100 includes a container 10 for storing contents such as cells, and a label 20 attached to the container 10. The cryopreservation container 100 is cooled with a temperature of 0 ° C. or lower, more specifically, liquid nitrogen at about −150 ° C. to −196 ° C. in a state in which the contents such as cells are accommodated to freeze the contents. Save the data as it is.

  The container 10 includes, for example, a bottomed cylindrical main body 11 that stores contents such as cells, and a cap 12 that seals an upper opening of the main body 11. The material of the container 10 is not particularly limited. For example, polypropylene or the like can be used as a main material constituting the main body 11, and polypropylene or polyethylene or the like can be used as a main material constituting the cap 12. In addition, the container 10 exemplified in the present embodiment has a cylindrical tube shape, but the shape of the container 10 is not particularly limited, and for example, any shape such as a flask shape, a bag shape, a dish shape, etc. is adopted. can do.

  The label 20 attached to the outer surface 10 a of the container 10 has a base material layer 21 and an adhesive layer 22. The main material constituting the base material layer 21 of the label 20 is, for example, a resin material such as white polyester, and the main material constituting the adhesive layer 22 is, for example, an acrylic adhesive.

  On the surface of the base material layer 21 of the label 20, identification information or the like of the contents stored in the container 10 is printed. An adhesive layer 22 for attaching the label 20 to the outer surface 10 a of the container 10 is provided on the back surface of the base material layer 21 of the label 20. The label 20 has a thickness of about 30 μm to 100 μm, for example, the base material layer 21 has a thickness of about 20 μm to 90 μm, for example, and the adhesive layer 22 has a thickness of about 10 μm to 80 μm, for example. ing.

  In the cryopreservation container 100 of the present embodiment, the label 20 attached to the container 10 includes a first portion 23 that surrounds the entire circumference of the container 10 and is attached to the outer surface 10a of the container 10, and the first portion 23. It has a pair of 2nd parts 24 and 24 extended from both ends, and a pair of 2nd parts 24 and 24 of the both ends of the 1st part 23 are joined.

  More specifically, it is possible to use a label 20 in which the length L of the label 20 is longer than the peripheral length l of the container 10 at the position where the label 20 is applied. And in the state which left the both ends of the length L direction of the label 20 used as the 2nd part 24, the intermediate part of the length L direction of the label 20 is affixed cyclically | annularly along the outer surface 10a of the container 10. The first portion 23 encloses the entire circumference of the container 10. Here, the lengths L1 and L1 of the one end in the length L direction and the other end of the label 20 remaining as the second portions 24 and 24 can be made substantially equal.

  Next, one end portion in the length L direction of the label 20 which is a pair of second portions 24 and 24 extending from both ends of the first portion 23 and the other end portion are joined to face each other. At this time, the second portions 24 and 24 of the label 20 are joined by the adhesive layers 22 and 22 facing each other. Thereby, the intermediate portion in the length L direction of the label 20 along the outer surface 10a of the container 10 becomes the first portion 23 that annularly surrounds the entire circumference of the container 10, and both end portions in the length L direction of the label 20 are the first. A pair of second portions 24, 24 that extend from both ends of the portion 23 and are joined to each other are formed, and the label 20 is annularly fixed around the container 10.

  Hereinafter, the operation of the cryopreservation container 100 of this embodiment will be described.

  In the cryopreservation container 100 of this embodiment, contents such as cells are accommodated inside the main body 11 from the opening of the main body 11 of the container 10, and the opening of the main body 11 is sealed by the cap 12. Further, the label 20 on which the identification information of the contents is displayed is attached to the outer surface 10a of the container 10 as described above.

  In this state, the cryopreservation container 100 is cooled to about −150 ° C. to −196 ° C. with, for example, liquid nitrogen, and stored in a state where the contents are frozen. The contents such as cells cryopreserved in the cryopreservation container 100 are thawed by returning the cryopreservation container 100 to room temperature, for example. There is a possibility that the adhesive force between the adhesive layer 22 of the label 20 and the outer surface 10a of the container 10 may be reduced due to the influence of moisture or the like due to such cooling at a low temperature or condensation on the outer surface 10a of the container 10.

  Here, the cryopreservation container 100 of the present embodiment includes a first portion 23 in which a label 20 attached to the container 10 surrounds the entire circumference of the container 10 and is attached to the outer surface 10a of the container 10; The second portion 24 extends from both ends of the portion 23. And the 2nd parts 24 and 24 of the both ends of the 1st part 23 are joined.

  That is, in the label 20, the second portion 24 extending from the first portion 23 surrounding the entire circumference of the container 10 is joined to another second portion 24 extending from the first portion 23, so that the entire circumference of the container 10 is obtained. It is fixed in an annular shape surrounding. Further, the bonding between the second portions 24 and 24 of the label 20 is a bonding between the labels 20, and is bonded more firmly than the adhesion between the adhesive layer 22 of the label 20 and the outer surface 10 a of the container 10. be able to.

  Therefore, the label 20 is not only the adhesive force between the adhesive layer 22 of the first portion 23 and the outer surface 10a of the container 10, but also by joining the second portions 24 and 24 to obtain a stronger adhesive force. An annular state surrounding the container 10 can be maintained. Thereby, even if the adhesive force between the adhesive layer 22 of the first portion 23 of the label 20 and the outer surface 10a of the container 10 decreases as described above, the label 20 is bonded to the second portions 24 and 24. Thus, the annular state surrounding the container 10 is maintained, and peeling from the container 10 is prevented.

  Further, the second portions 24 and 24 of the label 20 are joined together by the adhesive layers 22 and 22 facing each other. Thus, by bonding the adhesive layers 22 and 22 of the second portions 24 and 24 facing each other of the label 20, the adhesive layers 22 and 22 are integrated with each other, and the second portions 24 and 24 are made stronger. Can be joined.

  Furthermore, the cryopreservation container 100 of this embodiment is a dust generation source, does not include a structure such as a fiber sheet that has a high material cost and complicates the manufacturing process. Therefore, according to the cryopreservation container 100 of the present embodiment, it can be used in a field where a higher degree of cleanliness is required than before, and the manufacturing cost can be reduced as compared with the conventional case.

  As described above, according to the cryopreservation container 100 of the present embodiment, it is possible to prevent the label attached to the outer surface of the container from being peeled off, and to be used in a field that requires a higher degree of cleanliness than before. The manufacturing cost can be reduced as compared with the conventional case. The form in which the first portion 23 surrounds the container 10 is not limited to an aspect in which the entire circumference of the container 10 is annularly surrounded with the longitudinal center axis of the container 10 as the center. For example, the first portion 23 can extend in a direction parallel to the central axis in the longitudinal direction of the container 10 to surround the container 10 in an annular shape over the entire circumference in the longitudinal direction. The first portion 23 can also surround the container 10 in an annular shape over the entire circumference in a direction inclined with respect to the central axis in the longitudinal direction of the container 10.

[Embodiment 2]
FIG. 3A is a perspective view before the label 20 is attached to the container 10 of the cryopreservation container 100A according to Embodiment 2 of the present invention. 3B is a perspective view after the label 20 is attached to the container 10 of the cryopreservation container 100A shown in FIG. 3A. 4 is a cross-sectional view taken along line IV-IV of the cryopreservation container 100A shown in FIG. 3B.

  The cryopreservation container 100A of this embodiment is different from the cryopreservation container 100 described in the first embodiment in that it includes a pair of labels 20 and 20 that face each other. Other points of the cryopreservation container 100A of this embodiment are the same as those of the cryopreservation container 100 described in the first embodiment, and therefore, the same parts are denoted by the same reference numerals and description thereof is omitted.

  The cryopreservation container 100A includes a pair of labels 20 and 20 that face each other. The pair of labels 20 and 20 includes a pair of first portions 23 and 23 that face each other, and two pairs of second portions 24 and 24 that extend from both ends of the pair of first portions 23 and 23 and face each other. And two portions 24, 24. And two pairs of 2nd parts 24 and 24 and 2nd parts 24 and 24 of the both ends of the 1st part 23 are joined. That is, the second parts 24 and 24 at one end of the pair of first parts 23 and 23 and the second parts 24 and 24 at the other end of the first parts 23 and 23 are joined. Further, the second portions 24 and 24 are joined by the adhesive layers 22 and 22 facing each other.

  In this case, the sum of the lengths L2 and L2 of the first portions 23 and 23 of the pair of labels 20 and 20 can be made substantially equal to the circumferential length l of the container 10 at the position where the label 20 is applied. And each label 20 is made to oppose in the state which left the both ends of the length L direction on both sides of the container 10. FIG. Then, along the outer surface 10a of the container 10 disposed between the pair of labels 20 and 20, the intermediate portion in the length L direction of the pair of labels 20 and 20 is annularly attached, The first parts 23 and 23 are surrounded. For example, the length L2 of the first portion 23 of each label 20 can be approximately ½ each of the circumferential length l of the container 10 at the position where the label 20 is applied.

  Next, two pairs of end portions extending from both ends of the pair of first portions 23 and 23 that are intermediate portions in the length L direction of the pair of labels 20 and 20 facing each other are joined to each other. That is, the pair of second portions 24 and 24 facing each other at one end in the length L direction of the pair of labels 20 and 20 and the pair of second portions 24 and 24 facing each other at the other end in the length L direction are joined. To do.

  Thereby, the intermediate part of a pair of labels 20 and 20 along the outer surface 10a of the container 10 becomes the 1st parts 23 and 23 which surround the perimeter of the container 10, and both ends of the length L direction of a pair of labels 20 and 20 Becomes two pairs of second portions 24, 24 and second portions 24, 24 which are extended from both ends of the first portions 23, 23 and joined to each other, and the pair of labels 20, 20 are fixed in an annular shape from the container 10. It can prevent peeling.

  Further, the second portions 24 and 24 of the pair of labels 20 and 20 are joined together by the adhesive layers 22 and 22 facing each other. Thus, by bonding the adhesive layers 22 and 22 of the second portions 24 and 24 facing each other of the label 20, the adhesive layers 22 and 22 are integrated with each other, and the second portions 24 and 24 are made stronger. Can be joined.

  As described above, according to the cryopreservation container 100A of the present embodiment, the same effects as those of the cryopreservation container 100 described in the first embodiment can be obtained. Further, the cryopreservation container 100A of the present embodiment includes a pair of labels 20 and 20 facing each other, and has two pairs of second portions 24 and 24 and second portions 24 and 24, so that the cryopreservation container 100A has The area of the surface of the base material layers 21 and 21 of the labels 20 and 20 for displaying the identification information of the contents can be increased, and the visibility of the labels 20 and 20 can be improved.

[Embodiment 3]
FIG. 5A is a perspective view before the label 20 is attached to the container 10 of the cryopreservation container 100B according to Embodiment 3 of the present invention. FIG. 5B is a perspective view after the label 20 is attached to the container 10 of the cryopreservation container 100B shown in FIG. 5A. 6 is a cross-sectional view taken along line VI-VI of the cryopreservation container 100B shown in FIG. 5B.

  In the cryopreservation container 100 </ b> B of this embodiment, the label 20 has a first portion 23 and a second portion 24 extending from one end of the first portion 23, and the second portion 24 at one end of the first portion 23. And the other end of the first portion 23 are different from the cryopreservation container 100 of the first embodiment described above. Since the other points of the cryopreservation container 100B of this embodiment are the same as those of the cryopreservation container 100 described in the first embodiment, the same portions are denoted by the same reference numerals and description thereof is omitted.

  In the cryopreservation container 100B, the label 20 includes a first portion 23 that surrounds the entire circumference of the container 10 and is affixed to the outer surface 10a of the container 10, and a second portion 24 that extends from one end of the first portion 23. have. Here, the second portion 24 is a portion overlapping the surface 21 a of the base material layer 21 of the first portion 23. In the label 20, the second portion 24 at one end of the first portion 23 and the other end of the first portion 23 are joined. More specifically, the adhesive layer 22 of the second portion 24 is bonded to the surface 21 a of the base material layer 21 of the first portion 23.

  In this case, the label 20 whose length L is longer than the circumferential length l of the container 10 at the position where the label 20 is applied can be used. Then, one end in the length L direction of the label 20 is affixed to the outer surface 10a of the container 10, and the label 20 is affixed in an annular shape so as to be wound along the outer surface 10a of the container 10, A first portion 23 surrounding the periphery is used. And the other edge part of the length L direction of the label 20 used as the 2nd part 24 extended from the 1st part 23 is left.

  Next, the label 20 which is the second portion 24 extending from the other end portion of the first portion 23 to one end portion in the length L direction of the label 20 which is one end portion of the first portion 23. The other end in the length direction is joined. Thereby, the one end part of the length L direction of the label 20 stuck on the outer surface 10a of the container 10 and the middle part of the label along the outer surface of the container 10 surround the entire circumference of the container 10. It becomes part 23. Further, the other end portion in the length L direction of the label 20 becomes a second portion 24 that extends from one end of the first portion 23 and is joined to the other end of the first portion 23, and the label 20 is fixed in an annular shape. Can be prevented from peeling off from the container 10.

  Further, by bonding the adhesive layer 22 of the second portion 24 to the surface 21a of the base material layer 21 of the first portion 23, one of the first portions 23 that is one end in the length L direction of the label 20 is provided. The adhesive layer 22 at the end can be attached to the outer surface 10 a of the container 10, and the label 20 can be easily wrapped around the container 10. Then, after the label 20 is wound around the entire circumference of the container 10 to form the first portion 23, the label 20 is the other end portion in the length L direction of the label 20 and extends from the other end portion of the first portion 23. The second portion 24 to be attached is attached to the surface 21a of the base material layer 21 at one end portion of the first portion 23, so that the label 20 can be easily fixed in an annular shape.

  FIG. 7 is an enlarged cross-sectional view taken along line VII-VII of the cryopreservation container 100B shown in FIG. In the cryopreservation container 100 </ b> B of this embodiment, the surface 21 a of the base material layer 21 of the first portion 23 has an arithmetic average roughness Ra equal to or less than the thickness t of the adhesive layer 22 of the second portion 24 and the adhesive of the second portion 24. It is preferably 0.04 times or more the thickness t of the layer 22 and the ratio of the surface area to the unit plane area is 5 or more. Further, the thickness t of the adhesive layer 22 of the second portion 24 is preferably 10 μm or more.

  In other words, the label 20 of this embodiment is the label 20 for the cryopreservation container 100 </ b> B provided with the base material layer 21 and the adhesive layer 22. In this label 20, the surface 21 a of the base material layer 21 has an arithmetic average roughness Ra of not more than the thickness t of the adhesive layer 22 and not less than 0.04 times the thickness t of the adhesive layer 22. The ratio is preferably 5 or more. In addition, the ratio of the surface area to the unit plane area is a value obtained by dividing the surface area in an arbitrary region by the plane area of the region.

  The label 20 is formed with minute convex portions 21b and concave portions 21c on the surface 21a of the base material layer 21, so that the surface 21a of the base material layer 21 has a surface area with respect to the arithmetic average roughness Ra and the unit plane area. Have a ratio. The ratio of the surface area to the arithmetic average roughness Ra and the unit area of the surface 21a of the base material layer 21 can be calculated based on, for example, the surface shape measured using a laser microscope. The measurement range of the surface 21a of the base material layer 21 can be, for example, a 200 μm square range at an arbitrary position on the surface 21a of the base material layer 21. The arithmetic average roughness Ra can be measured according to, for example, JIS B 0601-1994.

  In the calculation of the arithmetic average roughness Ra of the surface 21a of the base material layer 21, for example, the reference length is 200 μm, and the arithmetic average roughness Ra of the surface 21a of the base material layer 21 is calculated along reference lines in three directions. And the average value can be made into arithmetic average roughness Ra. Here, a portion protruding above the average line of the roughness curve can be a convex portion 21b, and a portion recessed below the average line can be a concave portion 21c.

  The surface 21a of the base material layer 21 has the above-mentioned arithmetic average roughness Ra and the ratio of the surface area to the unit flat area, so that the surface 21a of the base material layer 21 of the first portion 23 has a minute convex having a predetermined average height. The part 21b and the recessed part 21c are formed with a predetermined density or more. Therefore, when the adhesive layer 22 of the second portion 24 is joined to the surface 21a of the base material layer 21 of the first portion 23, the minute convex portions 21b of the surface 21a of the base material layer 21 of the first portion 23 are second. While biting into the adhesive layer 22 of the portion 24, the adhesive layer 22 of the second portion 24 enters the minute concave portion 21 c of the surface 21 a of the base material layer 21 of the first portion 23.

  Moreover, the minute convex part 21b of the base material layer 21 of the 1st part 23 which penetrates the adhesion layer 22 of the 2nd part 24 and reaches the base material layer 21 of the 2nd part 24 can fully be reduced. Therefore, compared with the case where the adhesive layer 22 of the label 20 is applied to the outer surface 10a of the container 10, the bonding strength between the adhesive layer 22 of the second portion 24 and the base material layer 21 of the first portion 23 is increased. It is possible to maintain the state in which the label 20 surrounds the entire circumference of the container 10 in an annular shape, and to prevent the label 20 from peeling from the container 10.

  Further, when the thickness t of the adhesive layer 22 of the second portion 24 is 10 μm or more, not only the adhesive force of the adhesive layer 22 is ensured but also the arithmetic of the surface 21a of the base material layer 21 of the first portion 23. The average roughness Ra can be 0.4 μm or more. Therefore, when the adhesive layer 22 of the second portion 24 is joined to the surface 21a of the base material layer 21 of the first portion 23, the minute convex portion 21b of the surface 21a is sufficiently bitten into the adhesive layer 22 of the second portion 24. In addition, the adhesive layer 22 of the second portion 24 can sufficiently enter the minute concave portion 21 c of the surface 21 a of the base material layer 21 of the first portion 23.

  FIG. 8 is a flowchart of a method for manufacturing the label 20 for the cryopreservation container 100B of the present embodiment. The manufacturing method of the label 20 of the present embodiment includes a mold processing step S1 and an uneven transfer step S2.

  In the mold processing step S1, an uneven region is formed on at least a part of the mold. More specifically, for example, a blasting process is performed on a part or the whole of the mold for forming the surface shape of the surface 21a of the base material layer 21 of the label 20 to form unevenness, and then the uneven surface is plated. An uneven region is formed by applying. In the blasting treatment in which sand or metal fine particles collide with the mold surface, for example, fine particles of 0.01 μm or more and 1000 μm or less can be used. The arithmetic average roughness Ra of the concavo-convex region tends to be smaller as the particles colliding in the blasting process are smaller or the collision energy is lower, and conversely, the arithmetic mean roughness Ra is larger as the particles are larger or the collision energy is higher. Further, the ratio of the surface area to the unit flat area of the concavo-convex region is smaller as the number of colliding particles is smaller, and conversely is larger as the number of particles is larger.

  Thereby, for example, the arithmetic average roughness Ra is not more than the thickness of the adhesive layer 22 and not less than 0.04 times the thickness of the adhesive layer 22 in a part or the whole of the mold, and the ratio of the surface area to the unit plane area An uneven region having a thickness of 5 or more is formed. In addition, as a method of forming the uneven region on the mold, in addition to the blasting process, a chemical etching process, a plasma process, a corona process for etching a workpiece by applying a chemical reaction / corrosion action by a chemical such as an etchant. There are methods such as processing, laser processing, and cutting. In addition, a combination of photoresist techniques can also be used to produce a pattern-like uneven region such as a line shape or a lattice shape. Moreover, you may give metal plating, such as chromium, to an uneven | corrugated area | region as needed, in order to improve the intensity | strength of an uneven | corrugated area | region. As the material of the mold, for example, steel, ceramics, glass, or the like can be used.

  In the unevenness transfer step S2, the surface shape of the uneven region of the mold is transferred to at least a part of the surface 21a of the base material layer 21 of the label 20. The surface 21a of the base material layer 21 of the label 20 after the uneven transfer step S2 has an arithmetic average roughness Ra equal to or less than the thickness of the adhesive layer 22 and 0.04 times or more the thickness of the adhesive layer 22, The ratio of the surface area to the flat area is 5 or more.

  Thus, the manufacturing method of the label 20 for the cryopreservation container 100B of the present embodiment includes the mold processing step S1 and the unevenness transfer step S2. Thereby, the arithmetic mean roughness Ra of the surface 21a of the base material layer 21 is not more than the thickness t of the adhesive layer 22 and not less than 0.04 times the thickness t of the adhesive layer 22, and the ratio of the surface area to the unit flat area is The label 20 which is 5 or more can be easily manufactured.

  The embodiment of the present invention has been described in detail with reference to the drawings, but the specific configuration is not limited to this embodiment, and there are design changes and the like without departing from the gist of the present invention. They are also included in the present invention.

10 container, 20 label (label for cryopreservation container), 21 base material layer, 21a surface, 22 adhesive layer, 100 cryopreservation container, 100A cryopreservation container, 100B cryopreservation container, 10a outer surface, 23 first part, 24 Second part, S1 mold processing step, S2 uneven transfer step, t thickness

Claims (10)

A cryopreservation container comprising a label having a base material layer and an adhesive layer, and a container to which the label is attached,
The label has a first part that surrounds the container and is affixed to the outer surface of the container, and a second part that extends from both ends or one end of the first part,
The cryopreservation container, wherein the second parts at both ends of the first part or the second part at one end of the first part and the other end of the first part are joined. The label has the first portion and a pair of the second portions extending from both ends of the first portion,
The cryopreservation container according to claim 1, wherein the pair of second parts at both ends of the first part are joined to each other. A pair of the labels facing each other,
The pair of labels includes a pair of the first portions facing each other and two pairs of the second portions extending from both ends of the pair of the first portions and facing each other.
The cryopreservation container according to claim 1, wherein the two pairs of the second parts at both ends of the first part are joined to each other.   The cryopreservation container according to claim 2 or 3, wherein the second parts are joined together by the adhesive layers facing each other. The label has the first part and the second part extending from one end of the first part,
The cryopreservation container according to claim 1, wherein the second part at one end of the first part is joined to the other end of the first part.   The cryopreservation container according to claim 5, wherein the adhesive layer of the second part is bonded to the surface of the base material layer of the first part.   The surface of the base material layer of the first part has an arithmetic average roughness Ra of not more than the thickness of the adhesive layer and not less than 0.04 times the thickness of the adhesive layer, and the ratio of the surface area to the unit flat area is The cryopreservation container according to claim 6, which is 5 or more.   The cryopreservation container according to claim 7, wherein the adhesive layer of the second portion has a thickness of 10 µm or more. A label for a cryopreservation container provided with a base material layer and an adhesive layer,
The surface of the base material layer has an arithmetic average roughness Ra of not more than the thickness of the adhesive layer and not less than 0.04 times the thickness of the adhesive layer, and a ratio of a surface area to a unit plane area of 5 or more. A label for a cryopreservation container. A method for producing a label for a cryopreservation container comprising a base material layer and an adhesive layer,
A mold processing step for forming an uneven region by attaching particles having an average particle diameter equal to or less than the thickness of the adhesive layer to the mold, and
A concavo-convex transfer step of transferring the surface shape of the concavo-convex region of the mold to the surface of the base material layer,
The surface of the base material layer after the unevenness transfer step has an arithmetic average roughness Ra of not more than the thickness of the adhesive layer and not less than 0.04 times the thickness of the adhesive layer, A method for producing a pressure-sensitive adhesive label for a cryopreservation container, wherein the ratio is 5 or more.

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