JP2017048144A - W/o type emulsion composition - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide a W/O type emulsion composition which has a high inhibitory effect on the transpiration of a water content, good viscosity stability at low temperature, no stickiness and an excellent feeling of use.SOLUTION: A W/O type emulsion composition comprises: (A) one or more surfactants selected from (A-1) a glycerol fatty acid ester which is an ester compound of a fatty acid having 12 to 22 carbon atoms and glycerin, (A-2) a polyglycerol fatty acid ester which is an ester compound of a fatty acid having 12 to 22 carbon atoms and polyglycerol and (A-3) a polyoxyethylene hardened castor oil having an average addition mole number of polyoxyethylene of 5 to 20; (B) an oil solution which is liquid at 25°C; and (C) a polyethylene glycol which is solid at 25°C.SELECTED DRAWING: None

Description

  The present invention relates to a W / O type emulsion composition.

  Emulsions are classified into water-in-oil type (W / O) and oil-in-water type (O / W). Generally, water-in-oil type (W / O) emulsions suppress moisture transpiration and keep moisture. It is known for its high power. However, water-in-oil (W / O) emulsions are difficult to ensure low temperature stability, and a sticky feeling to use is a problem.

  In the past, oily bases such as petrolatum have been used to suppress moisture transpiration from the skin, but there are problems that the feeling of use is sticky, it is difficult to spread over a wide area, and water-soluble active ingredients cannot be formulated. It was. In addition, in order to ensure the stability of the W / O emulsion, measures such as increasing the amount of the oil to be blended or increasing the oil phase viscosity using an oil gelling agent have been taken. There were problems such as feeling and difficulty in spreading.

Japanese Patent Laid-Open No. 2001-151662

  The present invention has been made in view of the above circumstances, and provides a W / O type emulsion composition that has a high moisture transpiration control effect, good viscosity stability at low temperatures, and has no stickiness and good usability. Objective.

  As a result of intensive studies to achieve the above object, the present inventor has combined (A) a specific surfactant, (B) an oil agent that is liquid at 25 ° C, and (C) a polyethylene glycol that is solid at 25 ° C. The present inventors have found that a W / O-type emulsified composition having a high effect of suppressing moisture transpiration, good viscosity stability at a low temperature, no stickiness, and good usability can be obtained. It is.

Accordingly, the present invention provides the following W / O type emulsion composition.
[1]. (A) (A-1) Glycerin fatty acid ester that is an ester compound of a fatty acid having 12 to 22 carbon atoms and glycerin, (A-2) Polyglycerin that is an ester compound of a fatty acid having 12 to 22 carbon atoms and polyglycerol 1 or more types of surfactant chosen from fatty acid ester and the polyoxyethylene hydrogenated castor oil whose (A-3) polyoxyethylene average addition mole number is 5-20,
(B) A W / O emulsion composition containing an oil that is liquid at 25 ° C. and (C) polyethylene glycol that is solid at 25 ° C.
[2]. Furthermore, (D) W / O type emulsion composition as described in [1] containing a polyhydric alcohol.
[3]. The W / O emulsion composition according to [1] or [2], wherein the mass ratio of the water-soluble component and the oil-soluble component represented by (water-soluble component / oil-soluble component) is 3 to 8.
[4]. Furthermore, (E) W / O type emulsion composition in any one of [1]-[3] containing a solid wax at 25 degreeC.

  According to the present invention, it is possible to provide a W / O emulsified composition having a high moisture transpiration suppressing effect, good viscosity stability at low temperatures, no stickiness, and good usability.

Hereinafter, the present invention will be described in detail.
The component (A) is a surfactant and is one or more selected from the following (A-1) to (A-3), and two or more can be used in appropriate combination.

(A-1) Glycerin fatty acid ester that is an ester compound of a fatty acid having 12 to 22 carbon atoms and glycerin A glycerin fatty acid ester that is an ester compound of a fatty acid having 12 to 22 carbon atoms and glycerin is a monoester compound, specifically Specifically, glyceryl monooleate, glyceryl monomyristate, glyceryl monopalmitate, glyceryl monostearate, glyceryl monoisostearate and the like can be mentioned.

(A-2) Polyglycerin fatty acid ester which is an ester compound of a fatty acid having 12 to 22 carbon atoms and polyglycerin The polyglycerin fatty acid ester is preferably an ester compound of polyglycerin and a plurality of fatty acids. Polyglyceryl fatty acid esters having 2 or more, preferably 5-10 glycerin addition moles, such as polyglyceryl trioleate, polyglyceryl pentaoleate, polyglyceryl pentastearate, polyglyceryl heptaoleate, and polyglyceryl condensed ricinoleate. Further, from the viewpoint of low-temperature storage stability, fatty acids are preferably unsaturated fatty acids. In particular, 12 to 22 carbon atoms, preferably 14 to 18 unsaturated fatty acids having 3 to 10 carbon atoms, preferably 3 to 7 ester bonds, and the number of moles of glycerin added is 2 or more, preferably 5 to 10. Polyglycerin fatty acid esters are preferred. Specific examples include polyglyceryl trioleate, polyglyceryl pentaoleate, and polyglyceryl heptaoleate. Particularly preferred is decaglyceryl pentaoleate.

(A-3) Polyoxyethylene hydrogenated castor oil having a polyoxyethylene average addition mole number of 5 to 20 (A-3) As the component, polyoxyethylene hydrogenated castor oil (5EO), polyoxyethylene cured Castor oil (7E.O.), polyoxyethylene hydrogenated castor oil (10E.O.), polyoxyethylene hydrogenated castor oil (20E.O.) and the like. Among these, those having a polyoxyethylene (EO) average added mole number of 7 to 20 are preferable, and those of 10 are more preferable.

  The HLB of the component (A) is preferably 2 to 7, but the feature of the present invention is to use a specific component (A), and as is clear from the results of Examples and Comparative Examples described later, (A The effects of the present invention cannot be obtained even if HLB 2 to 7 other than the component) are used. In the present invention, HLB refers to a value obtained by the Griffin method (see Yoshida, Shindo, Ogaki, Yamanaka, edited by “New Edition Surfactant Handbook”, Engineering Books Co., Ltd., 1991, page 234). ).

  The blending amount of the component (A) in the W / O emulsion composition is preferably 2 to 18% by mass, more preferably 4 to 14% by mass, and further 6 to 12% by mass from the viewpoint of the intended effect. preferable. By making it 2% by mass or more, the moisture transpiration suppression effect is better, and by making it 18% by mass or less, non-stickiness is better.

(B) Oil agent liquid at 25 ° C. By blending a liquid oil agent at 25 ° C., the moisture transpiration suppression effect and low-temperature viscosity stability are improved. Liquid oils at 25 ° C include hydrocarbon oils such as squalane and liquid paraffin, ester oils such as isopropyl myristate and cetyl sebacate, higher alcohols such as oleyl alcohol, higher fatty acids such as oleic acid, dimethylpolysiloxane, cyclohexane Silicone oils such as methicone, pharmaceutical ingredients that are liquid at 25 ° C. such as ufenamate, crotamiton, diphenhydramine, vitamin A-containing mixtures such as vitamin A and vitamin A oil, vitamins such as vitamin A fatty acid esters, vitamins such as tocopherol acetate E is mentioned. These can be used individually by 1 type or in combination of 2 or more types. Among these, hydrocarbon oils such as squalane and liquid paraffin, and higher alcohols such as oleyl alcohol are preferable, and hydrocarbon oils such as squalane and liquid paraffin are preferable.

  The blending amount of the component (B) in the W / O emulsion composition is preferably 5 to 30% by mass, more preferably 10 to 25% by mass, and further preferably 15 to 20% by mass from the viewpoint of the intended effect. preferable. By controlling the content to 5% by mass or more, the moisture transpiration suppression effect is better.

(C) Polyethylene glycol solid at 25 ° C. By blending solid polyethylene glycol at 25 ° C., the moisture transpiration inhibiting effect and low-temperature viscosity stability are further improved, and the moisture transpiration inhibiting effect is particularly improved. Polyethylene glycol that is solid at 25 ° C. has an average molecular weight of 4,000 to 40,000, and can be used singly or in appropriate combination of two or more. Especially, the thing of 6,000-20,000 is preferable and the thing of 10,000-20,000 is more preferable. The average molecular weight is measured according to the average molecular weight test described in the 16th revision Japanese Pharmacopoeia.

  The blending amount of the component (C) in the W / O emulsion composition is preferably 1 to 10% by mass and more preferably 2 to 10% by mass from the viewpoint of the intended effect. By setting the content to 1% by mass or more, the moisture transpiration suppressing effect and the low-temperature viscosity stability are better. On the other hand, even if it exceeds 10 mass%, further improvement in low temperature viscosity stability cannot be obtained.

(D) Polyhydric alcohol It is preferable to mix | blend a polyhydric alcohol with the W / O type emulsion composition of this invention from the point which improves a moisture transpiration inhibitory effect. Examples of the polyhydric alcohol include divalent alcohols such as 1,3-butylene glycol, trivalent alcohols such as glycerin, alcohol alkyl ethers such as hexavalent alcohols such as D-sorbitol, sugar alcohols such as maltotetraose, Examples include mucopolysaccharides such as heparin-like substances, which can be used alone or in combination of two or more. Among these, 1,3-butylene glycol and glycerin are preferable.

  (D) As for the compounding quantity in the W / O type emulsion composition of a component, 3-20 mass% is preferable from the point of the target effect, and 5-17 mass% is more preferable.

(E) Solid wax at 25 ° C. The W / O emulsion composition of the present invention preferably contains a solid wax at 25 ° C. from the viewpoint of improving the moisture transpiration inhibiting effect and low-temperature viscosity stability. Examples of the wax that is solid at 25 ° C. include ester waxes such as beeswax, mole, and candelilla wax, and hydrocarbon waxes such as paraffin wax, ceresin, and microcristane wax, which may be used alone or in combination of two or more. Can be used. Among these, 25 ° C. solid hydrocarbon waxes such as paraffin wax, ceresin, and microkristane wax are preferable, and ceresin is more preferable.

  The blending amount of the component (E) in the W / O emulsion composition is preferably 0.1 to 5% by mass, more preferably 0.5 to 4% by mass from the viewpoint of moisture transpiration suppression effect and low-temperature viscosity stability. preferable. In addition, even if it exceeds 5 mass%, the improvement of the further effect cannot be expected.

  In the W / O type emulsion composition of the present invention, the mass ratio of the water-soluble component and the oil-soluble component represented by (water-soluble component / oil-soluble component) is preferably 3 to 8, more preferably 4 ~ 6. By setting the mass ratio to 3 or more, low temperature viscosity stability and non-stickiness are further improved. Further, when the viscosity is 8 or less, the low-temperature viscosity stability and the non-stickiness are further improved. The above ratio is a value obtained by rounding off the first decimal place.

  In the present invention, as disclosed in the 16th revision Japanese Pharmacopoeia, the water-soluble component is slightly soluble in water (less than 30 mL of water required to dissolve 1 g of solute) or more easily soluble in it. That is, the component whose water solubility exceeds 1 g / 30 mL. Similarly, the oil-soluble component refers to a component that is slightly less soluble in water (1 g / 30 mL) or less soluble, that is, a component having a water solubility of 1 g / 30 mL or less. The water-soluble component includes the component (C), the component (D) and the water component of the present invention, and the oil-soluble component includes the component (B) and the component (E). However, (A) component of this invention shall not be contained in any of the water-soluble component and oil-soluble component of the said mass ratio.

  The W / O emulsion composition of the present invention contains water. The compounding quantity in the W / O type emulsion composition of water is 40-85 mass% normally, and 50-70 mass% is more preferable.

  In the W / O type emulsion composition of the present invention, optional components blended in the W / O type emulsion composition are used alone or in combination of two or more, as long as the effects of the present invention are not impaired. An appropriate amount can be blended. Optional ingredients include other chemicals, moisturizers, thickeners, chelating agents, preservatives, powder components, solid fats and oils, waxes, solid hydrocarbon oils, film agents, UV absorbers, amino acids, organic amines, polymer emulsions , Water-soluble polymer compounds, and fragrances.

  The drug is not particularly limited as long as it can be incorporated into an external preparation, for example, prednisolone valerate acetate, glycyrrhetinic acid, tocopherol acetate, allantoin, methyl salicylate, isopropylmethylphenol, lidocaine, l-menthol, panthenol, Examples include urea.

  Examples of the humectant include chondroitin sulfate, hyaluronic acid, mucoitin sulfate, caronic acid, atelocollagen, cholesteryl-12-hydroxystearate, sodium lactate, bile salt, dl-pyrrolidone carboxylate, short chain soluble collagen, diglycerin. (EO) PO adduct, Izayoi rose extract, Achillea millefolium extract, Merirot extract and the like.

  Examples of the thickener include carboxyvinyl polymer, acrylic acid / alkyl methacrylate copolymer, gum arabic, carrageenan, caraya gum, gum tragacanth, carob gum, quince seed (malmello), casein, dextrin, gelatin, sodium pectate, allagin Sodium acid, methylcellulose, ethylcellulose, CMC (carboxymethylcellulose), hydroxyethylcellulose, hydroxypropylcellulose, PVA (polyvinyl alcohol), PVM (polyvinylmethylether), PVP (polyvinylpyrrolidone), sodium polyacrylate, dimethylacrylamide / acryloyldimethyltaurine Salt-crosslinked polymer, hydroxyethyl acrylate / acryloyldimethyltaurine salt-crosslinked polymer, Locust bean gum, guar gum, Tamarintogamu, dialkyldimethylammonium sulfate cellulose, xanthan gum, aluminum magnesium silicate, bentonite, hectorite, A1Mg silicate (Veegum), laponite, and the like silicic anhydride.

  Examples of the chelating agent include 1-hydroxyethane-1,1-diphosphonic acid, 1-hydroxyethane-1,1-diphosphonic acid tetrasodium salt, disodium edetate, trisodium edetate, tetrasodium edetate, Examples include sodium acid, sodium polyphosphate, sodium metaphosphate, gluconic acid, phosphoric acid, citric acid, ascorbic acid, succinic acid, edetic acid, and trisodium ethylenediaminehydroxyethyl triacetate.

  Examples of the preservative include methyl paraben, ethyl paraben, butyl paraben, phenoxyethanol and the like.

  Examples of the powder component include inorganic powders (for example, talc, kaolin, mica, sericite (sericite), muscovite, phlogopite, synthetic mica, saucite, biotite, vermiculite, magnesium carbonate, calcium carbonate, silicic acid. Aluminum, barium silicate, calcium silicate, magnesium silicate, strontium silicate, metal tungstate, magnesium, silica, zeolite, barium sulfate, calcined calcium sulfate (baked gypsum), calcium phosphate, fluorine apatite, hydroxyapatite, ceramic powder Metal soap (eg, zinc myristate, calcium palmitate, aluminum stearate), boron nitride, etc .; organic powder (eg, polyamide resin powder (nylon powder), polyethylene powder, polymethyl methacrylate powder, Styrene powder, copolymer resin powder of styrene and acrylic acid, benzoguanamine resin powder, polytetrafluoroethylene powder, cellulose powder, etc.); inorganic white pigment (for example, titanium dioxide, zinc oxide, etc.); inorganic red pigment ( For example, iron oxide (Bengara), iron titanate, etc.); inorganic brown pigment (for example, γ-iron oxide, etc.); inorganic yellow pigment (for example, yellow iron oxide, loess, etc.); inorganic black pigment (for example, Black iron oxide, low-order titanium oxide, etc.); inorganic purple pigments (eg, mango violet, cobalt violet, etc.); inorganic green pigments (eg, chromium oxide, chromium hydroxide, cobalt titanate, etc.); inorganic blue pigments (For example, ultramarine, bitumen, etc.); pearl pigments (for example, titanium oxide coated mica, titanium oxide coated bismuth oxychloride, titanium oxide coated titanium) Lac, colored titanium oxide coated mica, bismuth oxychloride, fish scale foil, etc.); metal powder pigments (eg, aluminum powder, copper powder, etc.); organic pigments such as zirconium, barium, or aluminum lake (eg, red 201, red 202) , Red 204, red 205, red 220, red 226, red 228, red 405, orange 203, orange 204, yellow 205, yellow 401, and blue 404 Red No. 3, Red No. 104, Red No. 106, Red No. 227, Red No. 230, Red No. 401, Red No. 505, Orange No. 205, Yellow No. 4, Yellow No. 5, Yellow No. 202, Yellow No. 203, Green No. 3 and Blue No. 1, etc.); natural pigments (for example, chlorophyll, β-carotene, etc.)

  Examples of the solid fat include cacao butter, palm oil, horse fat, hydrogenated palm oil, palm oil, beef tallow, sheep fat, hydrogenated beef tallow, palm kernel oil, pork fat, beef bone fat, owl kernel oil, hydrogenated oil, cattle Leg fats, moles, hydrogenated castor oil and the like.

  Examples of the ultraviolet absorber include benzoic acid-based ultraviolet absorbers (for example, paraaminobenzoic acid (hereinafter abbreviated as PABA), PABA monoglycerin ester, N, N-dipropoxy PABA ethyl ester, N, N-diethoxy PABA ethyl ester. N, N-dimethyl PABA ethyl ester, N, N-dimethyl PABA butyl ester, N, N-dimethyl PABA ethyl ester, etc.); anthranilic acid ultraviolet absorbers (for example, homomenthyl-N-acetylanthranylate, etc.); Salicylic acid UV absorbers (eg, amyl salicylate, menthyl salicylate, homomenthyl salicylate, octyl salicylate, phenyl salicylate, benzyl salicylate, p-isopropanol phenyl salicylate); (For example, octylmethoxycinnamate, ethyl-4-isopropylcinnamate, methyl-2,5-diisopropylcinnamate, ethyl-2,4-diisopropylcinnamate, methyl-2,4-diisopropylcinnamate, propyl-p- Methoxycinnamate, isopropyl-p-methoxycinnamate, isoamyl-p-methoxycinnamate, octyl-p-methoxycinnamate (2-ethylhexyl-p-methoxycinnamate), 2-ethoxyethyl-p-methoxycinnamate, Cyclohexyl-p-methoxycinnamate, ethyl-α-cyano-β-phenylcinnamate, 2-ethylhexyl-α-cyano-β-phenylcinnamate, glyceryl mono-2-ethylhexanoyl-diparamethoxycinnamate, etc. ); 3- (4′-methylbenzylidene) -d, l-camphor, 3-benzylidene-d, l-camphor; 2-phenyl-5-methylbenzoxazole; 2,2′-hydroxy-5-methylphenyl 2- (2'-hydroxy-5'-t-octylphenyl) benzotriazole; 2- (2'-hydroxy-5'-methylphenyl) benzotriazole; dibenzalazine; dianisoylmethane; 4-methoxy-4 '-T-butyldibenzoylmethane; 5- (3,3-dimethyl-2-norbornylidene) -3-pentan-2-one, dimorpholinopyridazinone and the like.

  Examples of amino acids include neutral amino acids (eg, threonine, cysteine, etc.); basic amino acids (eg, hydroxylysine, etc.) and the like. Examples of the amino acid derivative include acyl sarcosine sodium (lauroyl sarcosine sodium), acyl glutamate, acyl β-alanine sodium, glutathione, and pyrrolidone carboxylic acid.

  Examples of the organic amine include monoethanolamine, diethanolamine, triethanolamine, morpholine, triisopropanolamine, 2-amino-2-methyl-1,3-propanediol, 2-amino-2-methyl-1-propanol, and the like. Is mentioned.

  Examples of the polymer emulsion include an acrylic resin emulsion, a polyethyl acrylate emulsion, an acrylic resin liquid, a polyacryl alkyl ester emulsion, a polyvinyl acetate resin emulsion, and a natural rubber latex.

  The W / O type emulsified composition of the present invention is, for example, after adding a water phase heated to 60 to 80 ° C. to an oil phase heated and dissolved at 60 to 80 ° C. and emulsifying using a homomixer or the like. It can be obtained by cooling to room temperature.

  The viscosity of the W / O emulsion composition of the present invention is preferably 1 to 100 Pa · s at 25 ° C. The viscosity is measured mainly under the conditions of a B-type viscometer (25 ° C., 12 rpm, rotor No. 13).

  The pH (25 ° C.) of the W / O emulsion composition of the present invention is preferably 3-6 at 25 ° C., more preferably 4-6. As the pH adjuster, monovalent organic acids such as lactic acid or salts thereof, polyvalent organic acids such as citric acid, succinic acid, malic acid and / or salts thereof, boric acid or borax are preferable. The pH adjuster can be used singly or in appropriate combination of two or more, and the amount thereof is appropriately selected to be the pH of the W / O emulsion composition.

  EXAMPLES Hereinafter, although an Example and a comparative example are shown and this invention is demonstrated concretely, this invention is not restrict | limited to the following Example. In the following examples, unless otherwise specified, “%” in the composition represents mass%, and the ratio represents mass ratio.

[Examples 1 to 27, Comparative Examples 1 to 4]
A water phase (including (C) and (D) components) heated to the same temperature was added to an oil phase (including (A), (B), and (E) components) heated and dissolved at 70 ° C. . While maintaining the temperature, the mixture was emulsified at 6,000 rpm for 5 minutes using a homomixer (TK AUTO HOMO MIXER manufactured by Tokushu Kika Kogyo Co., Ltd.), and further stirred at 100 rpm using a paddle mixer. Until cooled. The following measurements and evaluations were performed on the obtained emulsion. The results are also shown in the table. In addition, as a result of determining an emulsion type by electrical conductivity, the emulsion obtained in the Example and the comparative example was a W / O type emulsion.

<Water transpiration control effect>
Seal the top of the glass cup poured with 10 g of water with filter paper, apply the emulsion to this part, leave it at 40 ° C. and 50% RH for 4 hours, measure the amount of water transpiration, and use the following formula: Based on moisture transpiration suppression rate (%): The suppression of moisture transpiration compared to the case where no emulsion was applied was calculated, and the suppression effect was evaluated according to the following evaluation criteria.
Moisture transpiration suppression rate (%) = [moisture transpiration of glass cup without application of emulsion (g) −water transpiration of glass cup with application of emulsion (g)] / moisture transpiration of glass cup without application of emulsion Amount (g) x 100
(Evaluation criteria for water transpiration suppression effect)
◎: Water transpiration suppression rate (%) is 90% or more ○: Water transpiration suppression rate (%) is 70% or more and less than 90% △: Water transpiration suppression rate (%) is 50% or more and less than 70% ×: Water transpiration suppression Rate (%) is less than 50%

<Low temperature viscosity stability>
The emulsion is stored at low temperature: −5 ° C. for 2 months, and the viscosity immediately after production and the viscosity after storage for 2 months are as follows using a B-type viscometer (Toki Sangyo Co., Ltd. RB-80L type). It was measured.
Rotor: No. 12
Measurement temperature: 25 ° C
12 rpm
In this measurement method, those having a value of 10 Pa · s or more were measured using a B-type viscometer (Tokyo Keiki ASB100 type) under the following conditions.
Rotor: No. 6
Measurement temperature: 25 ° C
20 rpm

From the measurement results, the viscosity retention rate (%) is calculated using the following formula, and the low-temperature viscosity stability is shown by the following evaluation criteria. The initial viscosity of the examples was 1 to 100 Pa · s.
Viscosity retention (%) = viscosity after storage for 2 months / viscosity immediately after production × 100
(Viscosity stability evaluation criteria)
7: 95% or more 6: 90% or more but less than 95% 5: 80% or more but less than 90% 4: 70% or more but less than 80% 3: 60% or more but less than 70% 2: 50% or more but less than 60% 1: less than 50% Measurement not possible (oil-water separation)
Accept 3 or more points

<No stickiness>
Ten panelists spread about 0.5 g of the emulsion on their forearms and performed sensory evaluation on the absence of stickiness after 5 minutes based on the following score. A result is shown with the following evaluation criteria based on the average score of 10 persons.
(Score)
6 points: I don't feel 5 points: I don't feel much 4 points: Slightly feel 3 points: I feel a little 2 points: I feel very much 1 point: I feel very much (evaluation criteria for non-stickiness)
6: Average point 5.5 or more 5: Average point 5.0 or more and less than 5.5 4: Average point 4.0 or more and less than 5.0 3: Average point 3.0 or more and less than 4.0 2: Average point 2 0 or more and less than 3.0 1: Average point less than 2.0 and 3 or more points as pass

The raw materials used in the above examples are shown below. Unless otherwise specified, the amount of each component in the table is a pure conversion amount.
・ Pentaoleic acid decaglyceryl (HLB3.5): Nihon Surfactant Industrial Co., Ltd. NIKKOL Decaglyn 5-OV
・ Glyceryl monooleate (HLB2.5): Nikko Chemicals Corporation NIKKOL MGO
Polyoxyethylene hydrogenated castor oil (10E.O.) (HLB6.5): Nikko Chemicals Corporation NIKKOL HCO-10
・ Diphenhydramine: Kongo Chemical JP Diphenhydramine ・ Ufenamate: Shiono Finesse Co., Ltd. Ufenamate Squalane: Nikko Chemicals Co., Ltd. NIKKOL Squalane oleyl alcohol: Claude Japan Co., Ltd. Novol-LQ- (JP)
・ Isopropyl myristate: Nikko Chemicals Corporation NIKKOL IPM-EX
Macrogol 20000: Sanyo Chemical Co., Ltd. Macrogol 20000, average molecular weight 20,000
Macrogol 6000: Sanyo Chemical Co., Ltd. Macrogol 6000, average molecular weight 6,000
・ Glycerin: Sakamoto Yakuhin Kogyo Co., Ltd. Japanese Pharmacopoeia Glycerin ・ Selecin: Nikko Rica Co., Ltd. Purified ceresin N
-Beeswax: Celerica NODA Co., Ltd. Deodorized and refined beeswax-D-sorbitol: Mitsubishi Corporation Foodtech Co., Ltd. Sorbit D-70
・ Heparin-like substance: LABORATORI DERIVATI ORGANICI HEPARINOID
・ Vitamin A oil: DSM Nutrition Japan Co., Ltd. Vitamin A oil ・ Tocopherol acetate: DSM Nutrition Japan Co., Ltd. Tocopherol acetate

Claims (4)

(A) (A-1) Glycerin fatty acid ester that is an ester compound of a fatty acid having 12 to 22 carbon atoms and glycerin, (A-2) Polyglycerin that is an ester compound of a fatty acid having 12 to 22 carbon atoms and polyglycerol 1 or more types of surfactant chosen from fatty acid ester and the polyoxyethylene hydrogenated castor oil whose (A-3) polyoxyethylene average addition mole number is 5-20,
(B) A W / O emulsion composition containing an oil that is liquid at 25 ° C. and (C) polyethylene glycol that is solid at 25 ° C.   The W / O emulsion composition according to claim 1, further comprising (D) a polyhydric alcohol.   The W / O emulsion composition according to claim 1 or 2, wherein the mass ratio of the water-soluble component and the oil-soluble component represented by (water-soluble component / oil-soluble component) is 3 to 8.   The W / O emulsion composition according to any one of claims 1 to 3, further comprising (E) a wax that is solid at 25 ° C.