JP2017036282A5 - - Google Patents

Description

In another aspect, the present invention provides a method for making an adhesive containing a chlorhexidine salt . The method includes providing an aqueous solution of at least one chlorhexidine salt, and actively drying the aqueous solution to obtain the chlorhexidine salt in its at least one solid form. The method further includes providing an adhesive component and providing a solvent compatible with the adhesive component. The method further includes dissolving the solid form of the chlorhexidine salt in the solvent to create a chlorhexidine salt solution. The method further includes the step of making the chlorhexidine- containing adhesive by combining the chlorhexidine salt solution with the adhesive component.

The present invention provides a unique approach for incorporating chlorhexidine gluconate into solvent-based adhesives such as solvent-based acrylic adhesives that are widely used in medical and surgical applications. In this novel process, chlorhexidine gluconate is preferably incorporated into the solvent-based adhesive by a freeze-drying or spray drying process of chlorhexidine gluconate to obtain a powder. This powder is then dissolved in a solvent compatible with the target adhesive, such as an acrylic adhesive. One example of a suitable solvent for a typical acrylic adhesive is methanol.

Claims (33)

Providing an aqueous solution of at least one chlorhexidine salt;
Obtaining the at least one solid form of chlorhexidine salt by actively drying the aqueous solution;
Preparing an adhesive component;
Providing a solvent compatible with the adhesive component;
Dissolving a solid form of chlorhexidine salt in the solvent to create a chlorhexidine salt solution;
Creating a chlorhexidine salt-containing adhesive by combining the chlorhexidine salt solution with the adhesive component;
A method for producing an adhesive containing a chlorhexidine salt . The method of claim 1 , wherein the aqueous solution comprises a total concentration of the at least one chlorhexidine salt from 1% by weight to the solubility limit of the at least one chlorhexidine salt.   The method of claim 1 or 2, wherein the at least one chlorhexidine salt comprises chlorhexidine digluconate. The concentration of chlorhexidine digluconate in the aqueous solution is either 20% or 40% by weight, The method of claim 3.   The method according to claim 1, wherein the aggressive drying includes either a freeze drying method or a spray drying method. The method according to claim 5, wherein the freeze-drying method is performed at a temperature in the range of -80 ° C to 10 ° C. The method according to claim 6, wherein the temperature is −50 ° C. to 0 ° C. The method of claim 7, wherein the temperature is −20 ° C. The method of claim 5, wherein the freeze-drying method is performed at a pressure in the range of 0.01 bar to 0.95 bar. The method of claim 9, wherein the pressure is between 0.10 bar and 0.50 bar. The method of claim 10, wherein the pressure is 0.18 bar.   The method of claim 1, wherein the solid form is a particulate form.   6. The method of claim 5, wherein the freeze drying method comprises spraying an aqueous solution of at least one chlorhexidine salt.   The method of claim 1, wherein the adhesive component is selected from the group consisting of (i) an adhesive component, (ii) an adhesive premix, and (iii) an adhesive formulation. The method of claim 14 , wherein the adhesive component is an adhesive formulation. The method of claim 15 , wherein the adhesive formulation is selected from the group consisting of acrylic adhesives, rubber adhesives, silicone adhesives, polyurethane adhesives, and combinations thereof. The method of claim 15 , wherein the adhesive formulation comprises an acrylic adhesive. The solvent is methanol The method of any of claims 1-17. Produced by the process according to any one of claims 1 to 18 adhesive formulation containing at least one chlorhexidine salt. 20. The formulation of claim 19 , wherein the adhesive is selected from the group consisting of acrylic adhesives, rubber adhesives, silicone adhesives, polyurethane adhesives, and combinations thereof. 20. The formulation of claim 19 , wherein the adhesive is an acrylic adhesive. The formulation according to any one of claims 19 to 21 , wherein the at least one chlorhexidine salt comprises chlorhexidine digluconate. 23. A formulation according to any one of claims 19 to 22 , wherein the chlorhexidine salt is in powder form and is produced by aggressive drying. 24. The formulation of claim 23 , wherein the aggressive drying process is a freeze drying process. 24. The formulation of claim 23 , wherein the aggressive drying process is a spray drying method. A medical article having an adhesive having antimicrobial properties, including an adhesive manufactured by the method according to any one of claims 1 to 18, a medical product. The adhesive formulation is:
27. The medical product of claim 26 , comprising an adhesive and at least one chlorhexidine salt. 28. The medical product of claim 27 , wherein the adhesive is selected from the group consisting of acrylic adhesives, rubber adhesives, silicone adhesives, polyurethane adhesives, and combinations thereof. 30. The medical product of claim 28 , wherein the adhesive is an acrylic adhesive. 28. The medical product of claim 27 , wherein the at least one chlorhexidine salt comprises chlorhexidine gluconate. The medical product according to any one of claims 27 to 30 , wherein the chlorhexidine salt is in a powder form and is produced by a positive drying process. 32. The medical product according to claim 31 , wherein the aggressive drying treatment is a freeze drying method. 32. The medical product according to claim 31 , wherein the aggressive drying process is a spray drying method.