JP2017025001A - Skin Cosmetic - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide a skin cosmetic which improves the permeability of carnitines into the skin as compared with conventional one, enhances the effect of carnitines further than before and suppresses stickiness of the skin after application.SOLUTION: There is provided a skin cosmetic which comprises the following components (A), (B) (C) and (D): (A) 0.01 to 3 mass% of a compound selected from carnitine, a derivative thereof and a salt thereof, (B) 0.01 to 3 mass% of a basic amine having 4 or 5 carbon atoms, (C) 1 to 18 mass% of an oil solution which is liquid at 25°C and (D) water, wherein the mass ratio [(A)/(B)] of component (A) to component (B) is 0.1 to 5.5.SELECTED DRAWING: None

Description

  The present invention relates to a skin cosmetic.

Cosmetics containing carnitines have been studied for the purpose of improving the moisture retention function on the skin and improving aging. For example, Patent Document 1 describes an epidermal ceramide production accelerator containing fatty acid and L-carnitine, and Patent Document 2 describes an aging skin improving agent composed of carnitine chloride.
Patent Document 3 describes skin cosmetics containing carnitines and pH adjusters as cosmetics containing carnitines stably. Patent Document 4 is excellent in appearance and odor stability. As cosmetics having a moisturizing effect and good usability, a skin external preparation containing carnitines, glycyrrhetinic acids, and a tenninka extract is described.

JP 2001-220345 A JP 2001-240538 A JP 2004-339143 A JP 2012-206976 A

However, in recent years, there has been a demand for higher effects by improving moisturizing function, aging, and the like due to increasing consumer awareness of makeup. However, the agents described in Patent Documents 1 and 2 are not so high in penetrability of carnitines into the skin that they can respond to consumer voices in recent years, and as a result, the effects are not fully exhibited. Moreover, since carnitine was very hygroscopic, it turned out that the skin after application | coating feels sticky.
Furthermore, although the cosmetics described in Patent Documents 3 and 4 improve the storage stability of cosmetics containing carnitines, such as the odor and appearance, the effects of carnitines are still sufficient to satisfy recent consumers. It wasn't something that could be done.

  The present invention relates to a cosmetic that improves the permeability of carnitines to the skin more than before, enhances the effects of carnitines more than ever, and further suppresses the stickiness of the skin after application.

The present inventors have solved the above-mentioned problems by using carnitines and basic amines in a specific ratio in combination with a specific amount of oil, and the high permeability of carnitines to the skin and the skin after application. It was found that a skin cosmetic material having both non-stickiness was obtained, and further, there was no generation of carnitine odor, and the skin cosmetic material permeated the skin after application.
In addition, as shown in the evaluation method of the examples described later, “permeability” is a relative value of the amount of carnitines that have penetrated into the skin, and “feels that the skin cosmetic has penetrated into the skin”. And means that after the skin cosmetic is familiarized with the skin, the skin cosmetic does not remain on the skin, and the skin permeates the skin.

The present invention includes the following components (A), (B), (C) and (D):
(A) 0.01 to 3% by mass of a compound selected from carnitine, a derivative thereof and a salt thereof,
(B) C1-C5 basic amine 0.01-3 mass%,
(C) 1-18% by mass of liquid oil at 25 ° C.
(D) It is related with the skin cosmetics which contain water and the mass ratio [(A) / (B)] of the component (A) with respect to a component (B) is 0.1-5.5.

  The skin cosmetic of the present invention improves the permeability of carnitines to the skin, and can sufficiently exhibit the effects of carnitines. Moreover, the stickiness of the skin after application | coating was suppressed and the feeling that the skin cosmetics osmose | permeated skin was obtained.

  The component (A) used in the present invention is a compound selected from carnitine, derivatives thereof and salts thereof (sometimes referred to as carnitines). Carnitine is the chemical name 4-trimethylamino-3-hydroxybutyric acid, and D-form and L-form exist as stereoisomers, and DL-form is known as a mixture, but L-form and DL-form are preferred, The body is more preferred.

  Examples of the carnitine derivative include O-alkanoylcarnitine, and specifically, acetylcarnitine described in JP-A-11-180851.

  As these carnitines, derivatives thereof or salts thereof, carnitine, acetylcarnitine or salts thereof represented by the following general formula (1) or (2) are preferable.

(Wherein R ¹ represents a hydrogen atom or an acetyl group, and X ⁻ represents an anion)
In the formula, examples of the anion (X ⁻ ) include chloride, sulfonate, nitrate, acetate, citrate, nicotinate, salicylate and the like, and at least one selected from chloride, sulfonate, and nitrate from the viewpoint of improving the moisturizing effect on the skin. The above is preferable, at least one selected from chloride and sulfonate is more preferable, and chloride is more preferable.
Specifically, L-carnitine, L-carnitine hydrochloride, L-carnitine sulfate, L-carnitine nitrate, acetyl-L-carnitine, acetyl-L-carnitine hydrochloride, acetyl-L-carnitine sulfate, acetyl- L-carnitine nitrate, acetyl-L-carnitine acetate, acetyl-L-carnitine citrate, acetyl-L-carnitine nicotinate, acetyl-L-carnitine salicylate, and the like. From the same viewpoint, L-carnitine, At least one selected from L-carnitine hydrochloride, L-carnitine sulfate, L-carnitine nitrate, acetyl-L-carnitine, acetyl-L-carnitine hydrochloride, acetyl-L-carnitine sulfate, acetyl-L-carnitine nitrate More than species are preferred, L-carnitine, L-carnitine Salt, L- least one, more preferably selected from carnitine sulfate, L- carnitine, L- least one more preferably selected from carnitine hydrochloride, L- carnitine hydrochloride is more preferred more.

  Component (A) can be used alone or in combination of two or more, and the content is 0.01% by mass or more and 0.1% by mass or more in the total composition from the viewpoint of improving the moisturizing effect on the skin. From the viewpoint of reducing stickiness, it is 3% by mass or less, preferably 1.5% by mass or less, and more preferably 0.8% by mass or less. Moreover, content of a component (A) is 0.01-3 mass% in the whole composition from the same viewpoint, 0.1-1.5 mass% is preferable, 0.3-0.8 mass % Is more preferable.

  Examples of the basic amine having 4 or 5 carbon atoms of the component (B) include 2-amino-2-hydroxymethyl-1,3-propanediol (tromethamine), aminomethylpropanol (AMP), aminomethylpropanediol ( AMPD) and the like, and 2-amino-2-hydroxymethyl-1,3-propanediol (tromethamine) is preferable from the viewpoint of improving the permeability of the component (A) to the skin.

  Component (B) can use 1 type (s) or 2 or more types, Content is 0.01 mass% or more in the whole composition from a viewpoint of improving the permeability to the skin of component (A), It is preferably 0.2% by mass or more, more preferably 0.4% by mass or more, and is 3% by mass or less, and 2% by mass or less from the viewpoint of suppressing stickiness and suppressing the generation of the odor of the component (A). Preferably, 0.8 mass% or less is more preferable. Moreover, content of a component (B) is 0.01-3 mass% in the whole composition from the same viewpoint, 0.2-2 mass% is preferable, 0.4-0.8 mass% is preferable. More preferred.

  In the present invention, the mass ratio [(A) / (B)] of the component (A) to the component (B) is 0.1 or more from the viewpoint of improving the permeability of the component (A) to the skin, 0.2 or more is preferable, 0.5 or more is more preferable, 0.6 or more is further preferable, 5.5 or less is preferable, 3 or less is preferable, 2 or less is more preferable, and 1.5 or less is more preferable. Moreover, the mass ratio [(A) / (B)] of the component (A) with respect to the component (B) is 0.1 to 5.5, preferably 0.2 to 3, preferably 0.00. 5 to 2 is more preferable, and 0.6 to 1.5 is more preferable.

The oil agent of component (C) is liquid at 25 ° C. Here, the liquid state means that the viscosity at 25 ° C. is 10,000 mPa · s or less. Viscosity was measured using a B-type viscometer (VISCOMETER TVB-10, manufactured by Toki Sangyo Co., Ltd.), Rotor No. It is measured at 4, 12 rpm for 1 minute.
Such a liquid oil agent is not limited as long as it is usually used in cosmetics. For example, linear or branched hydrocarbon oils such as liquid paraffin, light isoparaffin, liquid isoparaffin, squalane and squalene; Silicone oils such as siloxane, dimethylcyclopolysiloxane, methylphenylpolysiloxane, methylhydrogenpolysiloxane, higher alcohol-modified organopolysiloxane; monoester oils such as isononyl isononanoate and isotridecyl isononanoate; diesters such as neopentyl glycol dicaprate Oil; Triester oil such as tri (capryl / capric acid) glyceryl, triglyceryl 2-ethylhexanoate, triglyceride oleate; ether such as alkyl-1,3-dimethylbutyl ether ; Fluoropolyether, fluorine oils such as perfluoroalkyl ether silicone.
These oil agents may be naturally derived.

  Among these, from the viewpoint of suppressing the stickiness of the skin after application, at least one selected from hydrocarbon oil, silicone oil, diester oil, triester oil, and ether oil is preferable. Silicone oil, diester oil, triester More preferably, at least one selected from oils and ether oils, specifically, neopentyl glycol dicaprate, triglycerides oleate, squalane, alkyl-1,3-dimethylbutyl ether, dimethylpolysiloxane, dimethylcyclopolysiloxane At least one selected from the above is preferred. Moreover, what contains all these is preferable. The oleic acid triglyceride is preferably derived from olive oil.

  Component (C) can be used alone or in combination of two or more, and from the viewpoint of suppressing the stickiness of the skin after application, the content is 1% by mass or more in the total composition, and 3% by mass. The above is preferable, and 4% by mass or more is more preferable. From the viewpoint of improving the penetration of the component (A) into the skin, the feeling that the cosmetic has penetrated into the skin, and suppressing the stickiness of the skin after application, 18% by mass. It is below, 15 mass% or less is preferable, and 12 mass% or less is more preferable. Moreover, content of a component (C) is 1-18 mass% in the whole composition from the same viewpoint, 3-15 mass% is preferable and 4-12 mass% is more preferable. Moreover, it is preferable to contain ether oil and silicone oil from a viewpoint of suppressing the stickiness of the skin after application | coating.

  In the present invention, the mass ratio [(A) / (C)] of the component (A) to the component (C) improves the penetration of the component (A) into the skin and the feeling that the skin cosmetic has penetrated into the skin. From the viewpoint of suppressing the stickiness of the skin after application, 0.01 or more is preferable, 0.03 or more is more preferable, 0.04 or more is more preferable, 0.3 or less is preferable, and 0.15 or less is more preferable. 0.08 or less is more preferable. Moreover, 0.01-0.3 are preferable, as for the mass ratio [(A) / (C)] of the component (A) with respect to a component (C), 0.03-0.15 are more preferable, and 0.04- 0.08 is more preferable.

  In the present invention, the mass ratio [(C) / (B)] of the component (C) to the component (B) is preferably 1 or more, more preferably 5 or more, from the viewpoint of reducing the stickiness of the skin after application. 8 or more are more preferable, and from the viewpoint of improving the permeability of the component (A) to the skin, 110 or less is preferable, 40 or less is more preferable, and 30 or less is more preferable. Moreover, 1-110 are preferable from the same viewpoint, as for the mass ratio [(C) / (B)] of the component (C) with respect to a component (B), 5-40 are more preferable, and 8-30 are more preferable.

  The water content of component (D) is preferably 50% by mass or more, more preferably 60% by mass or more, and even more preferably 70% by mass or more in the total composition, from the viewpoint of suppressing the stickiness of the skin during application. 90 mass% or less is preferable, 85 mass% or less is more preferable, and 80 mass% or less is further more preferable. Moreover, 50 to 90 mass% is preferable in the whole composition from the same viewpoint, and, as for content of water, 60 to 85 mass% is more preferable, and 70 to 80 mass% is further more preferable.

The skin cosmetic of the present invention can further contain (E) a surfactant selected from nonionic surfactants and anionic surfactants, and can further improve storage stability.
The nonionic surfactant is not limited as long as it is used in normal cosmetics, for example, sorbitan fatty acid ester, monoglycerin fatty acid ester, polyglycerin fatty acid ester, propylene glycol fatty acid ester, sucrose fatty acid ester, Polyoxyethylene fatty acid ester, polyoxyethylene sorbitan fatty acid ester, polyoxyethylene alkyl ether, polyoxyethylene sorbitol fatty acid ester, polyoxyethylene glycerin fatty acid ester, polyoxyethylene propylene glycol fatty acid ester, polyoxyethylene castor oil, polyoxyethylene Hydrogenated castor oil, polyoxyethylene hydrogenated castor oil fatty acid ester, polyoxyethylene phytostanol ether, polyoxyethylene phytostearate Sueteru, polyoxyethylene cholestanol ether, polyoxyethylene cholesteryl ether, polyoxyalkylene-modified organopolysiloxane, polyoxyalkylene-alkyl co-modified organopolysiloxanes, and the like.
Among these, from the viewpoint of improving storage stability, at least one selected from monoglycerin fatty acid esters and polyoxyethylene fatty acid esters is preferable, and at least one selected from polyethylene glycol monostearate and glyceryl monostearate is preferable. More preferred. The glyceryl monostearate is preferably at least one selected from lipophilic glyceryl monostearate and self-emulsifying glyceryl monostearate.

Further, the nonionic surfactant is preferably HLB 3 to 10 and more preferably HLB 4 to 8 from the viewpoint of improving storage stability.
Here, HLB (hydrophilic-lipophilic balance <Hydrophilic-Lypophilic Balance>) indicates the molecular weight of the hydrophilic group part in the total molecular weight of the surfactant. For nonionic surfactants, Griffin (Griffin) formula is used.
Moreover, the nonionic surfactant can contain 1 type (s) or 2 or more types, HLB as the whole nonionic surfactant is as above-mentioned, and the nonionic surfactant in that case The HLB as a whole is calculated by averaging the HLB values of each nonionic surfactant based on the blending ratio.

Mixed HLB = Σ (HLBx × Wx) / ΣWx
HLBx indicates the HLB value of the nonionic surfactant X.
Wx represents the mass (g) of the nonionic surfactant X having a value of HLBx.

In addition, the anionic surfactant is not limited as long as it is used for ordinary cosmetics. For example, fatty acid salt having 12 to 24 carbon atoms, alkyl sulfate ester salt, alkyl ether sulfate ester salt, N-acyl sarcosine salt, N-acyl taurine salt having 12 to 22 carbon atoms, alkyl phosphate, polyoxyethylene alkyl ether Examples thereof include phosphate, long-chain sulfosuccinate, and N-acyl glutamate having 12 to 22 carbon atoms.
Among these, from the viewpoint of improving storage stability, at least one selected from fatty acid salts having 12 to 24 carbon atoms, N-acyl taurine salts having 12 to 22 carbon atoms, and N-acyl glutamate salts having 12 to 22 carbon atoms. More than species are preferred.

As the fatty acid constituting the fatty acid salt having 12 to 24 carbon atoms, it is a straight chain or branched chain fatty acid, and from the viewpoint of improving the storage stability, it is preferable that both the straight chain or branched chain fatty acid is contained. From the viewpoint, the number of carbon atoms is preferably 14-20, and more preferably 16-18.
In the N-acyl taurine constituting the N-acyl taurine salt having 12 to 22 carbon atoms, the acyl group may include a straight chain or a branched chain, and the straight chain is preferable from the viewpoint of improving storage stability, and the same viewpoint Therefore, the carbon number is preferably 14 to 20, and more preferably 16 to 18.
In the N-acylglutamic acid constituting the N-acylglutamate having 12 to 22 carbon atoms, the acyl group may include a straight chain or a branched chain, and a straight chain is preferable from the viewpoint of improving storage stability. Therefore, the carbon number is preferably 14 to 20, and more preferably 16 to 18.
Moreover, it is preferable to contain both a C12-24 fatty acid salt and a C12-22 N-acyl glutamate.

  Component (E) anionic surfactant neutralizer includes component (B) basic amine having 4 or 5 carbon atoms; alkali metal hydroxide such as sodium and potassium; alkaline earth such as calcium and magnesium Metal hydroxides; ammonium; alkanolamine-derived organic ammonium excluding component (B) such as monoethanolamine, diethanolamine, triethanolamine; and basic amino acids such as L-arginine. Among these, from the viewpoint of improving the stability, it is selected from basic amines having 4 or 5 carbon atoms of component (B), alkali metal hydroxides, and organic ammonium derived from alkanolamines excluding component (B). At least one or more are preferable, and at least one selected from basic amines having 4 or 5 carbon atoms and alkali metal hydroxides of the component (B) is more preferable.

  As the surfactant of component (E), one or more selected from nonionic surfactants and anionic surfactants can be used, and from the viewpoint of improving storage stability at 50 ° C. or higher, It is preferable to include both a nonionic surfactant and an anionic surfactant, and it is more preferable to include both a nonionic surfactant and a fatty acid salt having 12 to 24 carbon atoms.

The content of the component (E) is preferably 4% by mass or more, more preferably 4.5% by mass or more, still more preferably 5% by mass or more, in the total composition, from the viewpoint of improving storage stability. % By mass or less is preferable, 7% by mass or less is more preferable, and 6.5% by mass or less is more preferable. In addition, from the same viewpoint, the content of the component (E) is preferably 4 to 7.5% by mass, more preferably 4.5 to 7% by mass, and further 5 to 6.5% by mass in the total composition. preferable.
Moreover, when using the skin cosmetics of this invention in liquid form, from a viewpoint of suppressing the stickiness of the skin after application | coating more, 0.5 mass% or less is preferable, and, as for content of component (E), 0.1 mass % Or less is more preferable, 0.01 mass% or less is more preferable, and it is still more preferable not to contain substantially.
In addition, when a component (E) contains an anionic surfactant, content of those components in skin cosmetics shows the mass of an acid conversion amount.

The skin cosmetic of the present invention preferably further comprises (F) a solid oil agent at 25 ° C., so that the skin after application can have a matte finish. Here, solid at 25 ° C. means that the viscosity at 25 ° C. is larger than 10,000 mPa · s. The viscosity is measured in the same manner as component (C). Note that the matte finish means a natural finish without glaring gloss on the skin to which the skin cosmetic is applied.
Such oil agents are not limited as long as they are usually used in cosmetics, and animal waxes, plant waxes, mineral waxes, synthetic waxes, higher alcohols having 12 to 22 carbon atoms, and the like can be used. More specifically, animal waxes include gay wax, plant waxes include rice bran wax, carnauba wax, candelilla wax, beeswax and the like, and mineral waxes include ceresin, paraffin wax, microcrystalline. Examples of the synthetic wax include polyethylene wax and polyolefin wax.

Of these, vegetable waxes and mineral waxes are preferred, and mineral waxes are more preferred from the viewpoint of improving the matte finish and the feeling of penetration of skin cosmetics into the skin. Specifically, at least one selected from paraffin wax and ceresin is preferable.
In addition, as the component (F), from the viewpoint of improving the feeling of matte finish and penetration of skin cosmetics into the skin, those having a melting point of 50 to 90 ° C are preferable, those having 60 to 85 ° C are more preferable, and 70 A thing of -80 degreeC is more preferable.
The melting point is measured using a DP70 automatic dropping point / softening point measurement system (manufactured by METTLER TOLEDO).

  The component (F) can be used alone or in combination of two or more, and the content is 0.4% by mass or more in the total composition from the viewpoint of improving the feeling that the skin cosmetic has penetrated into the skin. Preferably, 0.8% by mass or more is more preferable, 1.5% by mass or more is more preferable, and from the viewpoint of suppressing stickiness and improving the feeling that the skin cosmetic has penetrated into the skin, 10% by mass or less is preferable. The mass% or less is more preferable, and 4.5 mass% or less is more preferable. In addition, from the same viewpoint, the content of the component (F) is preferably 0.4 to 10% by mass, more preferably 0.8 to 7% by mass, and 1.5 to 4.5% by mass in the total composition. Is more preferable.

  In the present invention, the mass ratio [(C) / (F)] of the component (C) to the component (F) is 0.5 from the viewpoint of suppressing stickiness and improving the feeling that the skin cosmetic penetrates into the skin. The above is preferable, 2.1 or more is more preferable, 2.5 or more is further preferable, 20 or less is preferable, 16 or less is more preferable, and 9 or less is further preferable. Moreover, from the same viewpoint, the mass ratio [(C) / (F)] of the component (C) to the component (F) is preferably 0.5 to 20, more preferably 2.1 to 16, and 2.5 ~ 9 is more preferred.

  The skin cosmetic of the present invention can contain other components used in ordinary cosmetics in addition to the above components. For example, surfactants other than component (E), C2-5 lower alcohol, moisturizer, water-soluble polymer, powder, antioxidant, preservative, chelating agent, fragrance, whitening agent, vitamins, etc. Various medicinal ingredients are listed.

The skin cosmetic of the present invention can be produced by a usual method.
For example, components (C), (E), (F) and other oil components are heated and stirred and dissolved, and then heated components (A), (B), (D) and other aqueous components are included. It can be produced by mixing the aqueous phase and then cooling with stirring.
Moreover, when an anionic surfactant is included as the component (E), the anionic surfactant is blended in the oil phase as an acid before neutralization, a base that is a neutralizing agent is blended in the aqueous phase, It is good also as a component (E) by neutralizing by mixing with an aqueous phase. Moreover, an anionic surfactant may be mix | blended with either the oil phase or the water phase in the state neutralized previously, and may be mix | blended with said method.

The skin cosmetics of the present invention can be skin care cosmetics such as skin lotions, cosmetic liquids, foundations, makeup bases, UV emulsions, tint emulsions, lip balms and the like. The cosmetic of the present invention can be applied as a liquid, gel, cream, emulsion or the like, and is preferably gel, cream, or emulsion because of its ease of application to the skin.
Furthermore, the skin cosmetics of the present invention can also be applied to both oil-in-water emulsified cosmetics and water-in-oil emulsified cosmetics, from the viewpoint of obtaining a fresh feel after application. An oil-in-water emulsified cosmetic is preferred.
This invention discloses the following compositions further regarding embodiment mentioned above.

<1> The following components (A), (B), (C) and (D):
(A) 0.01 to 3% by mass of a compound selected from carnitine, a derivative thereof and a salt thereof,
(B) C1-C5 basic amine 0.01-3 mass%,
(C) 1-18% by mass of liquid oil at 25 ° C.
(D) A skin cosmetic containing water and having a mass ratio (A) / (B) of component (A) to component (B) of 0.1 to 5.5.

<2> Component (A) is preferably L-carnitine, L-carnitine hydrochloride, L-carnitine sulfate, L-carnitine nitrate, acetyl-L-carnitine, acetyl-L-carnitine hydrochloride, acetyl-L -At least one selected from carnitine sulfate and acetyl-L-carnitine nitrate, more preferably at least one selected from L-carnitine, L-carnitine hydrochloride and L-carnitine sulfate; The skin cosmetic according to <1>, wherein at least one selected from carnitine and L-carnitine hydrochloride is more preferable, and L-carnitine hydrochloride is still more preferable.
The content of <3> component (A) is preferably 0.1% by mass or more, more preferably 0.3% by mass or more, and preferably 1.5% by mass or less in the total composition. The skin cosmetic according to <1> or <2>, wherein 8% by mass or less is more preferable.

<4> Component (B) is preferably 2-amino-2-hydroxymethyl-1,3-propanediol (tromethamine), aminomethylpropanol (AMP), aminomethylpropanediol (AMPD), and 2 The skin cosmetic according to any one of <1> to <3>, wherein -amino-2-hydroxymethyl-1,3-propanediol (tromethamine) is more preferable.
The content of <5> component (B) is preferably 0.2% by mass or more, more preferably 0.4% by mass or more, and preferably 2% by mass or less in the total composition, 0.8% by mass. % Of skin cosmetics according to any one of the above items <1> to <4>.
<6> The mass ratio [(A) / (B)] of the component (A) to the component (B) is preferably 0.2 or more, more preferably 0.5 or more, and 0.6 or more. The skin cosmetic according to any one of <1> to <5>, more preferably 3 or less, more preferably 2 or less, and further preferably 1.5 or less.

<7> The oil agent of component (C) is preferably at least one selected from hydrocarbon oils, silicone oils, diester oils, triester oils, and ether oils, and silicone oils, diester oils, triester oils More preferably, at least one selected from ether oils, at least one selected from neopentyl glycol dicaprate, triglycerides oleate, squalane, alkyl-1,3-dimethylbutyl ether, dimethylpolysiloxane, and dimethylcyclopolysiloxane. The skin cosmetic according to any one of the above items <1> to <6>, further preferably including all of them.
The content of <8> component (C) is preferably 3% by mass or more in the total composition, more preferably 4% by mass or more, preferably 15% by mass or less, and more preferably 12% by mass or less. The skin cosmetic according to any one of <1> to <7>.

<9> The mass ratio [(A) / (C)] of the component (A) to the component (C) is preferably 0.01 or more, more preferably 0.03 or more, and 0.04 or more. The skin cosmetic according to any one of <1> to <8>, more preferably 0.3 or less, more preferably 0.15 or less, and further preferably 0.08 or less.
<10> The mass ratio [(C) / (B)] of the component (C) to the component (B) is preferably 1 or more, more preferably 5 or more, further preferably 8 or more, and 110 or less. The skin cosmetic according to any one of <1> to <9>, preferably 40 or less, more preferably 30 or less.
The water content of <11> component (D) is preferably 50% by mass or more, more preferably 60% by mass or more, further preferably 70% by mass or more, and more preferably 90% by mass or less in the total composition. The skin cosmetic according to any one of <1> to <10>, preferably 85% by mass or less and more preferably 80% by mass or less.

<12> The skin cosmetic according to any one of <1> to <11>, further comprising (E) a surfactant selected from a nonionic surfactant and an anionic surfactant.
<13> The nonionic surfactant of component (E) is preferably at least one selected from monoglycerin fatty acid ester and polyoxyethylene fatty acid ester, and includes polyethylene glycol monostearate and glyceryl monostearate The skin cosmetic according to <12>, wherein at least one selected from:
<14> The skin cosmetic according to <12> or <13>, wherein the nonionic surfactant of the component (E) is preferably HLB3 to 10 and more preferably HLB4 to 8.

<15> The anionic surfactant of component (E) is preferably a fatty acid salt having 12 to 24 carbon atoms, an N-acyl taurine salt having 12 to 22 carbon atoms, or an N-acyl glutamate having 12 to 22 carbon atoms. The skin cosmetic according to the above <12>, which is at least one selected and more preferably contains both a fatty acid salt having 12 to 24 carbon atoms and an N-acyl glutamate having 12 to 22 carbon atoms.
<16> Component (E) preferably contains both a nonionic surfactant and an anionic surfactant, and more preferably contains both a nonionic surfactant and a fatty acid salt having 12 to 24 carbon atoms. The skin cosmetic according to any one of the above <12> to <15>.
The content of <17> component (E) is preferably 4% by mass or more in the total composition, more preferably 4.5% by mass or more, further preferably 5% by mass or more, and 7.5% by mass. The skin cosmetic according to any one of <12> to <16>, wherein the following is preferable, 7% by mass or less is more preferable, and 6.5% by mass or less is more preferable.

<18> The skin cosmetic according to any one of <1> to <17>, further comprising (F) a solid oil agent at 25 ° C.
<19> The component (F) is preferably a plant wax or mineral wax, more preferably a mineral wax, and more preferably at least one selected from paraffin wax and ceresin. .
<20> The component (F) preferably has a melting point of 50 to 90 ° C., more preferably 60 to 85 ° C., and further preferably 70 to 80 ° C. The skin cosmetic according to <18> or <19> .
The content of <21> component (F) is preferably 0.4% by mass or more, more preferably 0.8% by mass or more, still more preferably 1.5% by mass or more in the total composition. The skin cosmetic according to any one of the above items <18> to <20>, preferably at most mass%, more preferably at most 7 mass%, further preferably at most 4.5 mass%.
<22> The mass ratio [(C) / (F)] of the component (C) to the component (F) is preferably 0.5 or more, more preferably 2.1 or more, and 2.5 or more. The skin cosmetic according to any one of <18> to <21>, more preferably 20 or less, more preferably 16 or less, and further preferably 9 or less.

Examples 1-17, Comparative Examples 1-6
Skin cosmetics having the compositions shown in Tables 1 and 2 were produced and evaluated for permeability, non-stickiness, odor, matte finish, feeling that the skin cosmetic penetrated into the skin, and storage stability. The results are shown in Table 1 and Table 2 together.

(Production method)
Step 1:
The oil phase containing components (C), (E), (E ′), (F) and other oily components is heated to a temperature ranging from the melting point of the component having the highest melting point to a temperature 10 ° C. higher than the melting point. The mixture (1) was obtained by stirring.
Step 2:
A part of component (D) and other water-soluble components are mixed and heated in the range from the melting point of the component having the highest melting point in the component of mixture (1) to a temperature 10 ° C. higher than the melting point. The mixture (1) was heated to a temperature ranging from the melting point of the higher component to a temperature 10 ° C. higher than the melting point to obtain a mixture (2).
When mixing with the mixture (1), mixing was performed using a disper (manufactured by PRIMIX Corporation, Super High Speed Multi-stirring System Robomix (registered trademark)) at a stirring speed of 3500 rpm and a stirring time of 1 minute.
Step 3:
The mixture (2) was cooled to 50 ° C. or lower, and the component (A), the component (B) and the remainder of the component (D) were mixed to obtain a mixture (3).
When mixing with the mixture (2), mixing was performed using a homomixer (manufactured by PRIMIX Co., Ltd., ultra-high speed multi-stirring system Robomix (registered trademark)) at a stirring speed of 5000 rpm and a stirring time of 2 minutes.
Step 4:
The mixture (3) was cooled to 25 ° C. or lower to obtain a skin cosmetic.
Component (E), sodium N-stearoyl-L-glutamate, is blended as a neutralized salt, and component (E ′), stearic acid and isostearic acid, are neutralized with part of component (B), It is considered that it is an anionic surfactant (E).

(Evaluation method)
(1) Permeability (measured value):
(a) The surface of the pig skin is washed with a face wash to remove excess sebum and dried.
(b) A 24-hole plate (manufactured by ASONE) that cuts through the bottom of each columnar cell is placed on the pig skin.
(c) An equal amount of skin cosmetic is added to each cell, and the pig skin is contacted for a certain period of time (30 ° C., 16 hours).
(d) Remove the pig skin from the plate, and gently wash the surface of the pig skin that has been in contact with the skin cosmetic with a facial cleanser (so that the stratum corneum does not peel off).
(e) After the pork skin is dried, a tape is applied to the surface of the pig skin to remove the surface residue.
(f) Cut the pork skin that has been in contact with the skin cosmetic with a biopsy punch (8φ), put it in a screw tube (No. 3), add 1 mL of purified water, and extract the component (A).
(g) Extraction is performed with ultrasonic waves (manufactured by SND Corporation, ultrasonic cleaner, model number: US-3, transmission frequency: 38 KHz) for 20 minutes, and then vortexed well.
(h) The extract is passed through a 0.45 μm filter, put into an HPLC vial, and quantified by HPLC.
(i) The results are shown as relative values when the quantitative value of the component (B) that is not formulated (Comparative Example 1) is 1.

(HPLC conditions)
Detector: UV absorptiometer (measurement wavelength 210 nm) Setting concentration: 200 ppm
Column: 4.6 × 150 mm, 5 μm, CAPCELL PAK SCX UG80
Column temperature: 40 ° C
Mobile phase: 350 mL of a 0.03 mol / L potassium dihydrogen phosphate solution adjusted to pH 2.5 with phosphoric acid is added to 650 mL of acetonitrile.
Flow rate: 1 mL / min
Injection volume: 20 μL

(2) No stickiness:
Ten professional panelists evaluated the non-stickiness of the skin after applying 0.3 g of each skin cosmetic to the face. The results are shown in terms of the number of panelists evaluated as “no stickiness”.

(3) Smell:
Ten professional panelists performed sensory evaluation on the odor after each skin cosmetic 0.3g was applied to the face. The results are shown in terms of the number of panelists who rated “I don't mind the smell”.

(4) Matt finish:
Ten professional panelists performed sensory evaluation on the finish after applying 0.3 g of each skin cosmetic to the face. The results are shown in terms of the number of panelists evaluated as “finished on the mat”.
Note that the matte finish means a natural finish without glaring gloss on the skin to which the skin cosmetic is applied.

(5) Feeling that skin cosmetics penetrated into the skin:
Ten professional panelists applied 0.3 g of each skin cosmetic to the face and let it blend for 5 seconds, and then sensoryly evaluated the permeation of the skin cosmetic. The results are shown in terms of the number of panelists rated as “permeated”. In addition, “feeling that skin cosmetics penetrated into the skin” means that after the skin cosmetics are applied to the skin, the skin cosmetics do not remain on the skin, and the sensation of permeating the skin is obtained.

(6) Storage stability:
30 g of each skin cosmetic was placed in a 50 mL transparent screw tube and stored for one month at 25 ° C. or one month in a thermostatic chamber at 50 ° C., and then the appearance was visually observed. “3” indicates that there is no separation, and “2” indicates that the separation is 1 mm or less. “1” indicates separation that is greater than 1 mm.

Claims (6)

The following components (A), (B), (C) and (D):
(A) 0.01 to 3% by mass of a compound selected from carnitine, a derivative thereof and a salt thereof,
(B) C1-C5 basic amine 0.01-3 mass%,
(C) 1-18% by mass of liquid oil at 25 ° C.
(D) Skin cosmetics containing water and having a mass ratio [(A) / (B)] of component (A) to component (B) of 0.1 to 5.5.   The skin cosmetic according to claim 1, further comprising (E) a surfactant selected from a nonionic surfactant and an anionic surfactant.   The skin cosmetic according to claim 1 or 2, wherein the mass ratio [(A) / (C)] of component (A) to component (C) is 0.01 to 0.3.   The skin cosmetic according to any one of claims 1 to 3, wherein a mass ratio [(C) / (B)] of the component (C) to the component (B) is 1-110.   Furthermore, (F) Skin cosmetics of any one of Claims 1-4 containing a solid oil agent at 25 degreeC.   The skin cosmetic according to claim 5, wherein a mass ratio [(C) / (F)] of the component (C) to the component (F) is 0.5 to 20.