JP2017014162A - Sterilization sheet pack and method for producing sterilization sheet - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide a sterilization sheet pack with a simple constitution on general-purpose.SOLUTION: Provided is a sterilization sheet pack comprising: an inner bag 20 storing an alkaline solution 20a; compression sheets 30, 31, 32 including an acid component; and an outer bag 10 storing the inner bag and the compression sheets. Then, by breaking the inner bag 20 in the outer bag 10, the alkaline solution 20a and the acid component in the compression sheets are contacted to generate a hypochlorous acid liquid, and the compression sheets are impregnated with the hypochlorous acid liquid. Since, by contacting the alkaline solution and the acid component in the sheets, the hypochlorous acid liquid is generated immediately before use, high sterilization force can be exhibited. Further, by using the hypochlorous acid liquid having high safety, sterilization can be safely performed to operators and objects. Further, by using the alkaline solution 20a having reduced secular deterioration, the effective period of the sterilization sheet pack can be long secured.SELECTED DRAWING: Figure 1

Description

  The present invention relates to a sterilization sheet pack and a method for producing a sterilization sheet, and more particularly to a sterilization sheet pack for a sterilization sheet containing hypochlorous acid and a method for producing a sterilization sheet.

  For example, Patent Document 1 (International Publication No. 2004/098657) discloses a method of generating sterilized water containing hypochlorous acid or chlorous acid using hypochlorite and an acid.

  Patent Document 2 (Japanese Patent Laid-Open No. 2000-247808) discloses a disinfecting sheet having a disinfecting sheet to which a chlorine agent is attached and disinfecting water.

International Publication No. 2004/098657 JP 2000-247808 A

  In recent years, mass infections such as norovirus and influenza in hospitals and welfare facilities have become a problem. In particular, in recent years, it has become important to take measures to prevent secondary infection caused by highly infectious viruses. Such prevention of secondary infection is an important problem not only in hospitals and welfare facilities, but also in places where many people gather, such as schools, public facilities, and stations, and in general households.

  The present applicant has developed a sterilized water supply system that generates sterilized water containing hypochlorous acid to prevent infection and improve the sanitary environment. However, although the stationary system is very effective in a hospital or other facility where the system is installed, the range of use is limited and the cost required for capital investment is large.

  Therefore, development of a small sterilization sheet that has a simple configuration and can be used for general purposes is desired. However, hypochlorous acid tends to deteriorate over time as will be described later, and the effective period of the disinfecting sheet is shortened.

  An object of the present invention is to provide a disinfecting sheet pack that has a simple configuration and can be used for general purposes. In particular, an object of the present invention is to provide a disinfecting sheet pack that can safely disinfect workers and objects while maintaining a high disinfecting power. Another object of the present invention is to provide a sterilization sheet pack having a long effective period.

  The disinfecting sheet pack of the present invention has an inner bag containing an alkaline solution, a sheet containing an acid component, an outer bag containing the inner bag and the sheet, and in the outer bag, By breaking the inner bag, the alkaline solution and the acid component in the sheet are brought into contact with each other, a hypochlorous acid solution is generated by a reaction between the alkaline solution and the acid component, and hypochlorous acid is formed on the sheet. It is characterized by impregnating with an acid solution.

  The inner bag is, for example, a structure that is broken by a pressing force from the outside.

  The alkaline solution is, for example, a hypochlorite aqueous solution.

  The acid component is, for example, an organic acid.

  The organic acid is, for example, citric acid.

  The sheet is, for example, a compressed sheet.

  The method (use method) of the sanitization sheet of the present invention includes an inner bag containing an alkaline solution, a sheet containing an acid component, and an outer bag containing the inner bag and the sheet. Using a sheet pack, in the outer bag, by breaking the inner bag, the alkaline solution and the acid component in the sheet are brought into contact with each other, and hypochlorous acid is obtained by a reaction between the alkaline solution and the acid component. A liquid is produced, and the sheet is impregnated with a hypochlorous acid liquid.

  The inner bag is, for example, a structure that is broken by a pressing force from the outside.

  The alkaline solution is, for example, a hypochlorite aqueous solution.

  The acid component is, for example, an organic acid.

  The organic acid is, for example, citric acid.

  The sheet is, for example, a compressed sheet.

  In this sterilization sheet pack, since a hypochlorous acid solution is produced by bringing the alkaline solution into contact with the acid component in the sheet immediately before use, a high sterilization power can be exhibited. In addition, by using a highly safe hypochlorous acid solution, it is possible to safely sterilize workers and objects. In addition, by using an alkaline solution with little deterioration over time, it is possible to ensure a long effective period of the sterilization sheet pack.

  Moreover, the sanitization sheet | seat can be easily formed in a work place by making an inner bag into the structure broken by the pressing force from the outside.

  Further, by using an aqueous solution of hypochlorite as the alkaline solution, a hypochlorous acid solution having a high sterilizing power can be produced from a relatively low concentration aqueous solution of hypochlorite as a raw material. it can.

  Further, by using an organic acid as the acid component, it is possible to encapsulate the organic acid in the sheet while preventing deterioration of the sheet. In particular, by using citric acid as the organic acid, the acid component can be stably and safely included in the sheet.

  Further, by using a compressed sheet as the sheet, the water absorption of the sheet is increased, and a hypochlorous acid solution can be quickly generated.

It is a perspective view which shows the external appearance of a disinfection sheet pack. (A), (B) and (C) are top views which show the structure of a disinfection sheet pack. (A) And (B) is a figure which shows an example of the formation method of an inner bag or a compression sheet. It is a figure which shows an example of the accommodation method of the inner bag and compression sheet to an outer bag. It is a figure which shows the use process of a disinfection sheet pack. It is a figure which shows the use process of a disinfection sheet pack.

  Hereinafter, embodiments of the present invention will be described in detail with reference to the drawings.

(Configuration of sanitization sheet pack)
FIG. 1 is a perspective view showing the appearance of the sterilization sheet pack of the present embodiment, and FIG. 2 is a plan view showing the configuration of the sterilization sheet pack of the present embodiment. 2A shows an outer bag, FIG. 2B shows an inner bag, and FIG. 2C shows a compressed sheet. Moreover, FIG. 3 is a figure which shows an example of the formation method of an inner bag or a compression sheet. FIG. 3A shows the inner bag forming method, and FIG. 3B shows the compressed sheet forming method. Furthermore, FIG. 4 is a figure which shows an example of the accommodation method of the inner bag and compression sheet to an outer bag.

  As shown in FIGS. 1 and 2, the sterilization sheet pack of the present embodiment includes an outer bag 10, an inner bag 20, and compressed sheets 30, 31, and 32. The sanitizing sheet pack of the present embodiment is obtained by bringing the alkaline solution 20a in the inner bag 20 and the acid present in the compressed sheets 30, 31, and 32 into contact with each other in the outer bag 10 to thereby reduce hypochlorous acid. While producing the aqueous solution, the compressed sheet is impregnated with an aqueous solution of hypochlorous acid and swollen to form a sterilization sheet.

  In the inner bag 20, an alkaline solution 20a is enclosed (contained). The alkaline solution 20a is, for example, a hypochlorite aqueous solution. As hypochlorite, for example, sodium hypochlorite or potassium hypochlorite can be used. An aqueous solution of hypochlorite has little alteration (decomposition) due to long-term storage, and generates hypochlorous acid having a high sterilizing power by reaction with an acid, which will be described later. is there. The concentration of the aqueous solution of sodium hypochlorite is, for example, 125 ppm, and the enclosed amount is, for example, about 65 ml. In addition, in this specification, the density | concentration of the aqueous solution of sodium hypochlorite and the density | concentration of the aqueous solution of hypochlorous acid are the density | concentration calculated | required by residual chlorine concentration conversion.

In this way, even when a relatively low concentration aqueous solution is used, by reacting with an acid component (for example, citric acid), which will be described later, the amount of hypochlorous acid having a high sterilizing ability (the aqueous solution of hypochlorous acid) Concentration) can be generated. The concentration of the aqueous solution of sodium hypochlorite is not limited to the above concentration, and can be adjusted, for example, in the range of 50 ppm to 500 ppm. Within such a range, an effective amount of hypochlorous acid (concentration of an aqueous solution of hypochlorous acid) can be ensured while suppressing generation of harmful chlorine (Cl ₂ ). Moreover, the range of 50 ppm or more and 500 ppm or less is a range that has little influence on the human body even when touched directly. For this reason, even when the outer bag 10 and the inner bag 20 are damaged due to an unexpected impact or the like, and the aqueous solution of sodium hypochlorite leaks to the outside, there is little influence on the human body. Low irritation and skin irritation and high safety. Further, the amount of the sodium hypochlorite aqueous solution enclosed is not limited to the above amount, and can be adjusted, for example, in the range of 50 ml to 200 ml. Within this range, the weight is small and convenient to carry, and the package itself can be made small, so handling (handling) becomes easy. In addition, even when using the aqueous solution of potassium hypochlorite instead of the aqueous solution of sodium hypochlorite, the density | concentration can be adjusted, for example in the range of 50 ppm or more and 500 ppm or less. Also, the amount of the potassium hypochlorite aqueous solution sealed can be adjusted, for example, in the range of 50 ml to 200 ml.

  The material of the inner bag 20 is not limited as long as it does not change in quality due to the alkaline solution 20a to be enclosed, but for example, a polymer film can be used. As the polymer film, for example, polyethylene (PE), polyamide (PA), polyethylene terephthalate (PET), or the like can be used. Since these polymer films have high stability with respect to an alkaline solution and can be easily sealed by heat welding (heat sealing), they are suitable for use as an alkaline solution encapsulating material.

  Moreover, as a material of the inner bag 20, it is preferable to use what has light-shielding property. For example, you may use the silver film which gave aluminum vapor deposition to the said polymer film. Thus, by using the inner bag 20 having light shielding properties, it is possible to reduce the deterioration speed of the enclosed alkaline solution 20a, and it is possible to extend the expiration date (expiration date) of the sterilization sheet pack. .

  Further, the inner bag 20 has a structure that is broken by a pressing force from the outside. For example, as shown in FIG. 3 (A), an aqueous solution of hypochlorite (20a) is injected from an opening of a bag-like polyethylene film, both sides of which are thermally welded and the bottom is folded back, By thermally welding the part (upper part), the inner bag 20 in which the aqueous solution of hypochlorite is enclosed can be formed. Here, at the time of thermal welding of the opening (upper part), it is preferable to make the width of the thermal welding part 20b smaller than the width of the thermal welding part 20c on both sides. Moreover, it is preferable to make the heat welding part 20b of an opening part (upper part) into a zigzag shape. Among these, it is preferable that the zigzag repeating unit has a triangular shape. Thus, the zigzag-shaped portion is easily broken when a local stress is applied to the inner bag 20 by making the heat-welded portion 20b of the opening (upper portion) into a triangular zigzag shape. On the other hand, when pressure is evenly applied to the inner bag 20, the bag is unlikely to break. Thus, by using at least a part of the heat-welded part of the inner bag in a zigzag shape, the bag is easy to break when using the sterilization sheet pack, and at the time of transportation and storage of the sterilization sheet pack The bag can be made difficult to break.

  The compressed sheets 30, 31, and 32 are obtained by compressing a sheet-like base material made of paper or cloth. For example, it is formed by folding a sheet-like base material, inserting it into a cylindrical mold, and applying pressure from above. Such a compressed sheet is, for example, a sheet that is compressed into a small lump such as a disk shape, swells when impregnated with a liquid component, and unwinds into an original sheet shape in a state containing the liquid component. Paper or cloth can be used as the substrate. It is preferable to use a cloth from the viewpoint of strength. Synthetic fibers, recycled fibers, non-woven fabrics and the like can be used. As an example, rayon can be used. Rayon has a smooth touch and is highly hygroscopic. In addition, there is an advantage that no harmful substances are emitted by incineration or disposal. For example, a rayon having a size of 300 mm × 450 mm can be compressed into a disk-shaped lump having a diameter of about 45 mm and a height of about 7 mm, for example, by performing the above compression processing.

  Here, each of the compressed sheets 30, 31, and 32 of the present embodiment includes the acid component 30b in a fine solid (crystal) state (see FIG. 3B). The contained state may be solid, liquid or gel. The adsorption state of the acid component on the sheet may be physical adsorption or chemical adsorption. As the acid, an inorganic acid such as hydrochloric acid or an organic acid such as acetic acid or citric acid can be used. As the acid, it is preferable to use an organic acid rather than an inorganic acid. Organic acids are less corrosive to base materials than inorganic acids, and even when left for a long time with the acids themselves encapsulated, they can suppress the deterioration of base materials (for example, cloth and paper). it can. In addition, organic acids have less influence on the human body than inorganic acids, for example, less irritating and irritating to the skin. Among organic acids, citric acid is approved for use as a food additive and is therefore suitable as an acid component to be included in a compressed sheet. Moreover, since citric acid has a mold prevention effect, it can prevent mold and the like from growing on a substrate (for example, cloth or paper).

  As shown in FIG. 3 (B), an acid solution (acidic solution, 30b) is added to the compressed sheets (base materials) 30a, 31a, and 32a as a method of including the acid component in the compressed sheets 30, 31, and 32. , 31b, 31c), and the solution is absorbed by the compressed sheets 30, 31, 32, and then dried. For example, 0.1 ml of a 4% by weight aqueous citric acid solution is dropped on a compressed sheet made of the rayon material, and is naturally dried. Citric acid has a high solubility and is easy to produce an aqueous solution having a low concentration to a high concentration. For this reason, adjustment of the addition amount to a compression sheet becomes easy. Moreover, since citric acid has high solubility and can easily produce a high-concentration aqueous solution, the amount of the aqueous solution added to the compressed sheet can be reduced, and the drying time can be shortened. Moreover, about content of a citric acid, it can adjust with 5 mg-150 mg per compression sheet total number, for example. If the amount is such an amount, the concentration of the aqueous solution of sodium hypochlorite described above is adjusted, for example, in the range of 50 ppm to 500 ppm, and the amount of encapsulation is adjusted, for example, in the range of 50 ml to 200 ml. Can react well with sodium chlorite. Although it is possible to encapsulate an alkali component in the compressed sheets 30, 31, and 32 and react with an acidic solution, alteration by the compressed sheet due to the alkali component is likely to occur. In addition, the reaction with a small amount of moisture may cause an unexpected heat generation or a high-concentration alkaline solution. On the other hand, when the acid component is encapsulated in the compressed sheets 30, 31, and 32 as in the present embodiment, such heat generation and high-concentration alkaline liquid are not generated, and safety is high.

  The outer bag 10 contains the inner bag 20 in which the alkaline solution 20a is sealed, and the compressed sheets 30, 31, and 32 in which the acid component is included.

  As long as the material of the outer bag 10 is not altered by the alkaline solution 20a enclosed in the inner bag 20, the acid component contained in the compressed sheets 30, 31, 32, and the aqueous solution of hypochlorous acid as a product. Although there is no restriction, for example, a polymer film can be used. As the polymer film, for example, polyethylene (PE), polyamide (PA), polyethylene terephthalate (PET), or the like can be used. These polymer films are suitable for use as the outer bag 10 because they are highly stable with respect to the alkaline solution 20a, the acid component and the aqueous solution of hypochlorous acid, and can be easily sealed by thermal welding. is there.

  Moreover, as a material of the outer bag 10, it is preferable to use what has a transparent part (transparent window part) in at least one part. For example, a transparent film made of the above polymer film may be used. Thus, by using the outer bag 10 having the transparent portion (transparent window portion), the inner bag 20 is broken, the alkaline solution 20a is discharged from the inner bag 20, and the compressed sheets 30, 31, 32 are discharged. The impregnation state of the alkaline solution 20a can be confirmed. Thereby, it becomes possible to take out the compressed sheets 30, 31, 32 in a state where the sterilizing power is higher. The outer bag 10 may be at least partially transparent, and may be printed with a product name, a usage method, or the like on the other portion.

  For example, as shown in the left figure of FIG. 4, the other opening part (in the figure) of the bag-like polyethylene film heat-welded in a cylindrical shape and further, one of the left and right open parts (left side in the figure) is heat-welded From the right side, the inner bag 20 in which the alkaline solution 20a is enclosed and the compressed sheets 30, 31, 32 in which the acid component is included are inserted. Next, by thermally welding the opening (right side), the inner bag 20 in which the alkaline solution 20a is sealed and the compressed sheets 30, 31, 32 in which the acid component is included are accommodated in the outer bag 10. . Here, the number of compressed sheets accommodated is three, but the number of accommodated sheets can be changed as appropriate.

  Here, the pressing force that causes the outer bag 10 to break is larger than the pressing force that causes the inner bag 20 to break. For example, when pressure is gradually applied to the outer bag 10 in which the inner bag 20 is accommodated, the inner bag 20 is broken first. For example, the width of the heat welding part 10c of the outer bag 10 is made larger than the width of the heat welding part 20b of the inner bag. In this way, by increasing the width of the heat-welded portion 10c of the outer bag 10, even if the inner bag breaks, the outer bag does not break, and the alkaline solution 20a and the compressed sheet 30, Hypochlorous acid can be produced by sufficiently reacting with the acid component contained in the substances 31 and 32. And the aqueous solution of hypochlorous acid can fully swell to a compression sheet.

  Moreover, it is preferable that the guideline 10a is displayed on the outer bag 10. Using this guideline as a guide, local stress can be applied to the inner bag 20 by bending the inner bag 20 together with the outer bag 10. The guide line 10a is preferably provided in a direction perpendicular to the longitudinal direction of the outer bag 10 (longitudinal direction in the figure). Further, when the compressed sheets 30, 31, 32 are accommodated, the guide line 10a may be provided at a position corresponding to the boundary of the compressed sheet. In this case, the outer bag 10 is easily bent by the compressed sheets 30, 31, and 32 compressed into a disk-shaped lump, and the inner bag 20 is strongly sandwiched between the compressed sheets 30, 31, and 32 with the guideline 10a as a boundary. That is, the stress applied to the inner bag 20 can be increased (see FIG. 5).

  Further, the outer bag 10 may be provided with a cut end 10b. By providing the cut 10b, the outer bag 10 can be easily opened.

(How to use sanitization sheet pack)
Next, an example of how to use the disinfecting sheet pack will be described. 5 and 6 are diagrams showing a process of using the disinfecting sheet pack according to the present embodiment.

  As shown in FIG. 5, the inner bag (20) is folded together with the outer bag 10 according to the guideline 10 a of the outer bag 10. Thereby, a local stress is applied to the inner bag (20), and the inner bag (20) is broken.

  Specifically, the heat welding part 20b of the inner bag 20 is pierced (peeled) by the content (here, the alkaline solution 20a) to which pressure is applied. For example, as shown in FIG. 6A, the heat-welded portion 20b in the vicinity of the guideline 10a of the outer bag 10 is peeled off, and the alkaline solution 20a flows out from the peeled portion. In addition, the peeling part may occur at a position away from the guideline 10a. At this time, the outer bag 10 is not broken.

  An alkaline solution (here, an aqueous solution of sodium hypochlorite) 20a that has flowed into the outer bag 10 from the inner bag 20 comes into contact with the compressed sheets 30, 31, 32 and is sucked into the compressed sheets 30, 31, 32 ( (See the arrow in FIG. 6A). At this time, since the compression sheets 30, 31, and 32 contain acid components (in this case, citric acid solids or citric acid solution) 30b, 31b, and 32b, respectively, the compression sheets 30, 31, and 32 are included. The alkaline solution 20a sucked into the base reacts with the acid component (FIG. 6B).

By the above reaction, hypochlorous acid (an aqueous solution of hypochlorous acid) is generated. For example, when an aqueous solution of sodium hypochlorite (NaClO) is used as the alkaline solution and citric acid (C ₆ H ₈ O ₇ ) is used as the acid component, NaClO is monovalent and C ₆ H ₈ O _{Since 7} is trivalent, they theoretically react at a ratio of 3: 1. By this reaction, hypochlorous acid (HOCl) is generated (free). The generated HOCl is dissolved in water of an aqueous solution of sodium hypochlorite.

  The generated aqueous solution of hypochlorous acid is sucked into the compressed sheets 30, 31 and 32. Further, when the alkaline solution (here, an aqueous solution of sodium hypochlorite) 20a is sucked into the compressed sheets 30, 31, 32, it reacts with the acid component in the compressed sheets 30, 31, 32, and the compressed sheet 30 , 31 and 32, it can be said that an aqueous solution of hypochlorous acid is obtained.

  Thus, the compression sheets 30, 31, and 32 containing the aqueous solution of hypochlorous acid can be formed. The compressed sheets 30, 31, 32 containing an aqueous solution of hypochlorous acid can be taken out by tearing the outer bag 10 from the cut edge 10b.

  An aqueous solution of sodium hypochlorite also has the ability to disinfect, but the solution of strong alkali needs to be handled carefully depending on the concentration, and can generate harmful substances such as chlorine by reacting with the acid component. .

On the other hand, the aqueous solution of hypochlorous acid produced in the present embodiment is neutral to slightly acidic, is gentle to the hand, and is safe. In addition, it has high sterilizing power against microorganisms such as bacteria and viruses. For example, Hypochlorous acid (HOCl), ClO contained in an aqueous solution of sodium hypochlorite ^- having about 80 times the disinfecting power of. Such high sterilization power of hypochlorous acid (HOCl) is considered to be caused by a high oxidizing action of hypochlorous acid (HOCl). It can destroy and inactivate bacterial cell membranes and viral protein shells with strong oxidizing power.

  Thus, since hypochlorous acid has a high sterilizing power, an aqueous solution of hypochlorous acid can be sealed in an inner bag, soaked in a compressed sheet, and used as a sterilizing sheet. However, hypochlorous acid tends to deteriorate over time as compared with sodium hypochlorite. For this reason, even if it preserve | saved in the state enclosed with the inner bag, the effective period as a disinfection sheet | seat becomes short with about one year, for example. On the other hand, when it encloses in the inner bag in the state of the aqueous solution of sodium hypochlorite, the effective period as a disinfection sheet | seat can be made into 2 years or more, for example.

  In particular, viral diseases such as influenza and norovirus are often prevalent in winter. For this reason, even if the sterilization sheet pack is prepared in advance, if the effective period is short, the effective period may pass and the sterilizing power may be reduced. On the other hand, if it is a sterilization sheet pack that can guarantee a period of use of 2 years or more, it can effectively respond to viral epidemics such as influenza and norovirus, and can exert its effect.

  Furthermore, norovirus has high infectivity and is susceptible to secondary infection. In addition, there are many cases of mass infection. For this reason, it is effective to use a disinfecting sheet pack that has a high disinfecting power and is easy to handle. Although there is no restriction | limiting in the usage object and usage method of the sanitization sheet | seat formed with the sanitization sheet pack of this Embodiment, For example, it can use as follows. For example, for the treatment of vomiting, the vomiting is covered with a first compressed sheet to prevent the vomiting from scattering. Cover and wipe with disposable paper or cloth. The wiped product should be placed in a plastic bag and sealed to be discarded. Further, the wiped portion is wiped with a second compressed sheet. In addition, wipe the operator's vinyl gloves with the third compressed sheet.

  As described above, the aqueous solution of hypochlorous acid is a solution that is also gentle to the hand, so it is gentle to the material to be wiped, for example, the table, floor, hallway, etc., and prevents alteration of the table, floor, hallway, etc. can do.

  Thus, according to the sterilization sheet pack of the present embodiment, hypochlorous acid having a high sterilization power can be generated at the time of use of the sterilization sheet, and quickly and effectively, It can be sterilized.

  Moreover, according to the disinfecting sheet pack of the present embodiment, it is possible to safely disinfect the hypochlorous acid without adversely affecting the worker or the object.

  Moreover, according to the sterilization sheet pack of the present embodiment, it is possible to ensure a long effective period of the sterilization sheet pack by using an alkaline solution with little deterioration over time.

(Example)
The sterilization performance against E. coli and Staphylococcus aureus was evaluated using the sterilization sheet pack of the present embodiment. Here, the sterilization performance test was carried out in accordance with the sterilization performance test of wet wipers of the Japan Clean Paper Cotton Industry Association standard.

<< Test method >>
[Test substance]
Disinfecting sheet pack (compressed dry wiper disinfectant mixture)
[Used medium, etc.]
1) Medium used: Standard agar medium (Eiken Chemical), Normal agar medium (Eiken Chemical), Normal bouillon medium (Eiken Chemical)
2) Reagents used:
Phosphate buffer solution: 1.25 ml of 0.25 M phosphate buffer (pH 6.8 to 7.2) diluted to 1 L Purified water (Japan Pharmacopoeia): Kominato Pharmaceutical Co., Ltd. Model soil substance: 0.6 w / v% Bovine Serum Albumin (Cohn Fraction V)
Washing solution: 5 g of polysorbate 80 and 5 g of sodium carbonate were dissolved in water to make 1 L, 2.5 g of wetting solution and 2.5 g of sodium carbonate were added to water to make 5 L.

Deactivator: SCDLP broth medium (Eiken Chemical)
3) Equipment, etc. Control test cloth: Approx. 1 x 3m ² cloth (Kanakin No. 3) is placed in the washing solution and boiled for 1 hour. After changing the water and boiling for about 5 minutes, about 4-5L of cold water is used. The mixture was stirred for 5 minutes, dried, cut to 15 × 10 cm ² , sterilized by autoclaving, and dried.

    Wiping device: It consists of three parts: weight (150g), guide, and rail.

Test carrier: stainless steel flat plate, 26 × 152 × 1.0 mm, surface grade 2B
The test carrier was washed with an alkaline detergent, rinsed thoroughly with purified water, washed with alcohol and dried, and then used after dry sterilization.

[Test bacterial solution]
The following test bacteria were pre-cultured under a predetermined condition using a normal agar medium, and then adjusted to 1.0 to 5.0 × 10 ⁹ cfu / mL with a normal bouillon medium. Each test bacterial solution was prepared by adding an equal amount of a model soil substance to this adjusted bacterial solution and sufficiently suspending it.

Escherichia coli NBRC3972
Staphylococcus aureus NBRC12732
[Effectiveness confirmation test of deactivator]
Prior to the sterilization performance test, a test for confirming the effectiveness of the inactivating agent against two test bacterium species was performed, and the effectiveness was confirmed according to the following criteria.

-Criteria for determining the effectiveness of inactivating agents-
The effectiveness of the inactivating agent was confirmed as follows for each test species and test sample.

1) The viable cell count of the test bacterial solution is 0.5 to 2.5 × 10 ⁹ cfu / mL.

  2) In confirming the effect of the inactivating agent, the viable cell count of the system to which the test sample is added should be 50% or more of the viable cell count of the system to which an appropriate diluent is added instead of the test sample.

[Sterilization performance test method]
1) Test procedure A test bacterial solution was prepared by adding equal amounts of the adjusted bacterial solution and the model soil substance, suspending them sufficiently and keeping them under ice cooling.

  Thoroughly stir the test bacteria solution, inoculate 0.01 mL of the solution with a pipetter so that a line is drawn in the center of the test carrier, spread it with platinum ears, etc., and leave it for 5 to 15 minutes in a clean bench The dry state was confirmed visually. This was set in a wiping device, and a test substance (injecting one bag of sterilizing liquid into three compressed dry wipers) was attached to the weight, and placed on a guide for wiping operation. In the wiping operation, the weight was lightly pressed from above, the sample surface was brought into close contact with the surface of the test carrier, and the weight was reciprocated along the rail 5 times at intervals of about 1 second so that no pressure was applied from above.

  Immediately after completion of the wiping operation, the weight was removed and the carrier was allowed to stand for 5 minutes. Then, the carrier was transferred to a stomacher bag to which 20 mL of an inactivation treatment agent was added, and bacteria applied to the surface under predetermined conditions were washed out. Transfer 1 mL of this undiluted stock solution to a test tube containing 9 mL of phosphate buffer and stir. Further, after appropriately diluting 10 times, the undiluted undiluted solution and each series diluted solution were each 1. Dispensing 0 mL, adding 15 to 20 mL of standard agar medium kept at 46 to 48 ° C. per dish, culturing at 35 ± 1 ° C. for 48 ± 4 hours, and measuring the number of colonies grown.

  A control test cloth was inoculated with a phosphate buffer solution of 1.5 times the weight of the cloth.

The test was performed three times (n = 3) under the same conditions in both the treatment group and the control group.
2) Requirements for test completion A test was considered to have been satisfied when all of the following conditions were satisfied.

a. The viable count (N) of the test bacterial solution is 0.5 to 2.5 × 10 ⁹ cfu / mL.

  b. The viable cell count (Nc) of the control group is (Log (N × 0.01) −LogNc <3).

  c. The viable cell count (Ne) immediately after drying is 10% or more of the viable cell count of the test bacterial solution.

Ne / (N × 0.01) × 100> 10%
d. After wiping 3 times with the control sample and the test sample, the difference between the maximum value and the minimum value of the number of remaining bacteria should be 1 or less logarithmically.

3) Calculation of sanitization activity value The sanitization activity value (R) was calculated | required by following Formula, the 2nd decimal place was rounded off, and it displayed with 1 decimal place.

R = AB
Here, A: the average value of the common logarithm of the viable cell count (Nc) as a result of three trials with the control sample,
B: Average value of common logarithm of viable count (Nd) as a result of three trials with the test sample,
It is.

<< Test results >>
The results of the sterilization performance test (Table 1), determination of test establishment conditions (Table 2), and the number of recovered bacteria in each dilution series (Table 3) are shown below.

About the inactivation agent used for a test, ie, SCDLP broth culture medium, the effectiveness confirmation test was done whether the antibacterial activity of the test substance with respect to colon_bacillus | E._coli and Staphylococcus aureus can be stopped.

  As a result, the SCDLP broth medium had a ratio of the number of recovered bacteria treated with the test substance to the number of recovered bacteria in the untreated group was 0.9 for E. coli and 1.0 for Staphylococcus aureus. In the confirmation of the effect of the agent, the number of viable bacteria in the system to which the test sample was added was 50% or more of the number of viable bacteria in the system to which an appropriate diluent was added instead of the test sample. It was determined that the disinfecting component of the disinfecting sheet pack had an inactivating action.

  In the disinfection activity test using Escherichia coli and Staphylococcus aureus, disinfection activity values of 1.5 for Escherichia coli and 0.9 for Staphylococcus aureus were obtained.

(Summary)
Thus, 65 ml of an aqueous solution of sodium hypochlorite having a concentration of 125 ppm was sealed, and the sterilization component of the test substance (sanitization sheet pack) containing 12 mg of citric acid per 3 compressed sheets was E. coli and It was confirmed to have an inactivating action against S. aureus.

Here, although E. coli and Staphylococcus aureus were examined, norovirus and influenza virus are considered to have an inactivating action. For example, in examining the effect of a sterilized water supply system that produces sterilized water containing hypochlorous acid developed by the present applicants, the inactivation action of hypochlorous acid having a concentration of about 15 ppm was verified. Yes. At the time of this verification, almost 100% inactivation of 2.6 × 10 ⁴ Escherichia coli was confirmed with hypochlorous acid having a concentration of about 15 ppm. Moreover, the inactivation effect with respect to 1.6 * 10 < ⁶ > type A influenza virus and 6.3 * 10 < ⁵ > feline calicivirus (norovirus substitution) is confirmed. The action time against the virus is 7 seconds, 15 seconds and 30 seconds. Each virus was below the detection limit after treatment.

  In such hypochlorous acid of about 15 ppm, inactivation of E. coli, influenza virus and norovirus has been confirmed, and in the test substance (sanitized sheet pack), the concentration of hypochlorous acid is 125 ppm. Therefore, it is considered that norovirus and influenza virus also have an inactivation effect.

  In this example, an aqueous solution of sodium hypochlorite having a concentration of 125 ppm was used. As described above, the concentration of the aqueous solution of sodium hypochlorite is adjusted, for example, in the range of 50 ppm to 500 ppm. Can do. Moreover, the amount of sealing can also be adjusted in the range of 50 ml or more and 200 ml or less, for example. The amount of citric acid can also be adjusted, for example, from 5 mg to 150 mg per total number of compressed sheets.

  As mentioned above, the invention made by the present inventor has been specifically described based on the embodiment. However, the present invention is not limited to the above embodiment, and various modifications can be made without departing from the scope of the invention. Needless to say.

  For example, in the above embodiment, a compressed sheet is used, but a simple sheet such as paper or cloth may be used. Since paper and cloth also have water absorption properties, they are suitable for use as sheets in this embodiment. However, by using a compressed sheet, the water absorption of the sheet becomes larger, and a hypochlorous acid solution can be generated quickly.

  In the above embodiment, the alkaline solution 20a may contain various additives (for example, preservatives and pH adjusters). Further, the compression sheet may be subjected to antiseptic treatment.

DESCRIPTION OF SYMBOLS 10 Outer bag 10a Guideline 10b Cut 10c Thermal welding part 20 Inner bag 20a Alkaline solution 20b Thermal welding part 20c Thermal welding part 30, 31, 32 Compression sheet 30a, 31a, 32a Sheet 30b, 31b, 32b Acid component

Claims (12)

An inner bag containing an alkaline solution;
A sheet containing an acid component;
An outer bag for accommodating the inner bag and the sheet,
In the outer bag,
By breaking the inner bag, the alkaline solution and the acid component in the sheet are brought into contact with each other, and a hypochlorous acid solution is generated by a reaction between the alkaline solution and the acid component,
Impregnating the sheet with hypochlorous acid solution,
A disinfecting sheet pack characterized by that. In the sterilization sheet pack according to claim 1,
The inner bag is a structure that is broken by a pressing force from the outside.
A disinfecting sheet pack characterized by that. In the sterilization sheet pack according to claim 1,
The alkaline solution is an aqueous solution of hypochlorite,
A disinfecting sheet pack characterized by that. In the sterilization sheet pack according to claim 3,
The acid component is an organic acid.
A disinfecting sheet pack characterized by that. In the sterilization sheet pack according to claim 4,
The organic acid is citric acid.
A disinfecting sheet pack characterized by that. In the sterilization sheet pack according to claim 1,
The sheet is a compressed sheet;
A disinfecting sheet pack characterized by that. An inner bag containing an alkaline solution;
A sheet containing an acid component;
Using a disinfecting sheet pack having the inner bag and the outer bag containing the sheet,
In the outer bag,
By breaking the inner bag, the alkaline solution and the acid component in the sheet are brought into contact with each other, and a hypochlorous acid solution is generated by a reaction between the alkaline solution and the acid component,
Impregnating the sheet with hypochlorous acid solution,
A method for producing a disinfecting sheet. In the manufacturing method of the sanitization sheet according to claim 7,
The inner bag is a structure that is broken by a pressing force from the outside.
A method for producing a disinfecting sheet. In the manufacturing method of the sanitization sheet according to claim 7,
The alkaline solution is an aqueous solution of hypochlorite,
A method for producing a disinfecting sheet. In the manufacturing method of the sanitization sheet according to claim 9,
The acid component is an organic acid.
A method for producing a disinfecting sheet. In the manufacturing method of the sanitization sheet according to claim 10,
The organic acid is citric acid.
A method for producing a disinfecting sheet. In the manufacturing method of the sanitization sheet according to claim 7,
The sheet is a compressed sheet;
A method for producing a disinfecting sheet.