JP2016537411A5 - - Google Patents
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- Publication number
- JP2016537411A5 JP2016537411A5 JP2016551088A JP2016551088A JP2016537411A5 JP 2016537411 A5 JP2016537411 A5 JP 2016537411A5 JP 2016551088 A JP2016551088 A JP 2016551088A JP 2016551088 A JP2016551088 A JP 2016551088A JP 2016537411 A5 JP2016537411 A5 JP 2016537411A5
- Authority
- JP
- Japan
- Prior art keywords
- fatty acid
- soy flour
- flour extract
- hydroxy derivative
- batch size
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 235000014113 dietary fatty acids Nutrition 0.000 claims 11
- 239000000194 fatty acid Substances 0.000 claims 11
- 150000004665 fatty acids Chemical class 0.000 claims 10
- 235000010469 Glycine max Nutrition 0.000 claims 6
- 235000013312 flour Nutrition 0.000 claims 6
- 238000000034 method Methods 0.000 claims 2
- 230000001590 oxidative Effects 0.000 claims 2
- 239000003638 reducing agent Substances 0.000 claims 2
- WLKCSMCLEKGITB-DBVSHIMFSA-N (5Z,8Z,11Z,13E,15S,17Z)-15-hydroxyicosa-5,8,11,13,17-pentaenoic acid Chemical group CC\C=C/C[C@H](O)\C=C\C=C/C\C=C/C\C=C/CCCC(O)=O WLKCSMCLEKGITB-DBVSHIMFSA-N 0.000 claims 1
- XUJNEKJLAYXESH-REOHCLBHSA-N L-cysteine Chemical compound SC[C@H](N)C(O)=O XUJNEKJLAYXESH-REOHCLBHSA-N 0.000 claims 1
- 102000003820 Lipoxygenases Human genes 0.000 claims 1
- 108090000128 Lipoxygenases Proteins 0.000 claims 1
- 230000000875 corresponding Effects 0.000 claims 1
- 235000018417 cysteine Nutrition 0.000 claims 1
- 230000000694 effects Effects 0.000 claims 1
- 238000001914 filtration Methods 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 230000003647 oxidation Effects 0.000 claims 1
- 238000007254 oxidation reaction Methods 0.000 claims 1
- MYMOFIZGZYHOMD-UHFFFAOYSA-N oxygen Chemical compound O=O MYMOFIZGZYHOMD-UHFFFAOYSA-N 0.000 claims 1
- 229910052760 oxygen Inorganic materials 0.000 claims 1
- 239000001301 oxygen Substances 0.000 claims 1
- 235000020777 polyunsaturated fatty acids Nutrition 0.000 claims 1
- HOBAELRKJCKHQD-QNEBEIHSSA-N γ-Homolinolenic acid Chemical compound CCCCC\C=C/C\C=C/C\C=C/CCCCCCC(O)=O HOBAELRKJCKHQD-QNEBEIHSSA-N 0.000 claims 1
Claims (15)
- 脂肪酸の15-ヒドロキシ誘導体の生産のための方法であって、
少なくとも1.1バール〜約4バールの酸素雰囲気下で脂肪酸を酸化して、15-ヒドロペルオキシ脂肪酸中間体を形成すること、及び
還元剤を使用して、該脂肪酸の15-ヒドロペルオキシ誘導体を形成することを含む、前記方法。 - 前記酸化の工程が、前記脂肪酸を、該脂肪酸の1グラム当り400Mユニット未満と接触させることを含む、請求項１記載の方法。
- 少なくとも約50％の前記脂肪酸の15-ヒドロキシ誘導体の収率が得られる、請求項１又は２記載の方法。
- 前記15-ヒドロキシ誘導体が、15(S)-HETrEである、請求項１〜３のいずれか一項記載の方法。
- 前記15-ヒドロキシ誘導体が、15(S)-ヒドロキシエイコサペンタエン酸である、請求項１〜４のいずれか一項記載の方法。
- 前記還元剤が、システインを含む、請求項１記載の方法。
- 前記脂肪酸が、DGLAを含む、請求項１記載の方法。
- 前記脂肪酸が、多価不飽和脂肪酸を含む、請求項１記載の方法。
- 前記脂肪酸の15-ヒドロキシ誘導体が、95％ wt/wt以上の純度を有する、請求項１記載の方法。
- 前記バッチサイズが、100kg以上である、請求項１記載の方法。
- 前記バッチサイズが、250kg以上である、請求項１記載の方法。
- 前記バッチサイズが、500kg以上である、請求項１記載の方法。
- 前記酸化が、前記脂肪酸を大豆粉抽出物と接触させることを含む、請求項１記載の方法。
- 大豆粉をpH4.5の緩衝液と接触させて、粗製の大豆粉抽出物を生成すること；及び
該粗製の大豆粉抽出物を濾過して、前記大豆粉抽出物を生成することを更に含む、請求項１３記載の方法。 - 前記大豆粉抽出物が、約2mg/mLの精製された凍結乾燥リポキシゲナーゼ酵素に相当する活性を有する、請求項１４記載の方法。
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361896901P | 2013-10-29 | 2013-10-29 | |
| US61/896,901 | 2013-10-29 | ||
| PCT/IB2014/003086 WO2015063617A2 (en) | 2013-10-29 | 2014-10-29 | Methods of making 15-hydroxy fatty acid derivatives |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2016537411A JP2016537411A (ja) | 2016-12-01 |
| JP2016537411A5 true JP2016537411A5 (ja) | 2017-12-07 |
| JP6659557B2 JP6659557B2 (ja) | 2020-03-04 |
Family
ID=52669636
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016551088A Active JP6659557B2 (ja) | 2013-10-29 | 2014-10-29 | １５−ヒドロキシ脂肪酸誘導体の作製方法 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US9670126B2 (ja) |
| EP (1) | EP3063118B1 (ja) |
| JP (1) | JP6659557B2 (ja) |
| CN (1) | CN106170470B (ja) |
| ES (1) | ES2670776T3 (ja) |
| WO (1) | WO2015063617A2 (ja) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP6996755B2 (ja) * | 2016-06-30 | 2022-02-03 | 備前化成株式会社 | ω３およびω６不飽和脂肪酸酸化物の製造方法 |
| WO2021112310A1 (ko) * | 2019-12-06 | 2021-06-10 | 한국생명공학연구원 | 다중불포화지방산의 모노-하이드록시 또는 디-하이드록시 유도체, 이의 생산 방법 및 이의 용도 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1088058C (zh) * | 1994-10-13 | 2002-07-24 | 肽技术有限公司 | 经修饰的多不饱和脂肪酸 |
| US20040122126A1 (en) * | 2002-12-20 | 2004-06-24 | Dong Wu | Free-radical initiator systems containing enzymes, compositions, and methods |
| US7893106B2 (en) * | 2004-11-19 | 2011-02-22 | Martek Biosciences, Corporation | Oxylipins from stearidonic acid and γ-linolenic acid and methods of making and using the same |
| US20100144009A1 (en) | 2006-12-20 | 2010-06-10 | Protech Research Pty Ltd. | Extracting And Purifying Lipoxygenase |
| JP2010110246A (ja) * | 2008-11-05 | 2010-05-20 | Kao Corp | ９位過酸化脂肪酸の製造方法 |
-
2014
- 2014-10-29 ES ES14843235.4T patent/ES2670776T3/es active Active
- 2014-10-29 WO PCT/IB2014/003086 patent/WO2015063617A2/en active Application Filing
- 2014-10-29 US US14/527,601 patent/US9670126B2/en active Active
- 2014-10-29 CN CN201480071389.7A patent/CN106170470B/zh active Active
- 2014-10-29 EP EP14843235.4A patent/EP3063118B1/en active Active
- 2014-10-29 JP JP2016551088A patent/JP6659557B2/ja active Active
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