JP2016537133A - 真皮黒皮症を治療する方法及び装置 - Google Patents
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Abstract
Description
本願は、引用によりその開示が全体として本明細書に組み入れられる2013年8月9日出願の米国特許仮出願第61/864,238号に関連し、その優先権を主張するものである。
本開示の例示的な実施形態は、色素沈着組織の治療に関し、より具体的には、真皮黒皮症を治療する方法及び装置に関する。
本開示の1つの付加的な例示的実施形態において、第1のレンズ機構220は、放出体機構210からのEMR150を第2のレンズ機構230に向けて又はその上に誘導するように適合させ及び/又は構成することができる。第1のレンズ機構220は、例えば、1つ又はそれ以上のレンズ、反射体、部分的に又は完全に銀メッキされたミラー、プリズム、及び/又はビームスプリッタを含むことができる。例えば、第1のレンズ機構220は、放出体機構210から放出されたEMR150を、図2に示すように、第2のレンズ機構230の上に向けて平行化又は位置調整するように構成することができる。第1のレンズ機構220は、例えば、対物レンズなどを含むことができる。
Claims (32)
- 皮膚組織の真皮層内の少なくとも1つの色素沈着領域に選択的に影響を及ぼすための装置であって、
少なくとも1つの電磁放射を放出するように構成された放射機構と、
前記装置の少なくとも一部分が前記皮膚組織の表面に接触するか又はその上に配置されるとき、前記少なくとも1つの電磁放射を前記真皮層内の少なくとも1つの焦点領域内に誘導し合焦させるように構成された光学機構と、
を備え、
前記少なくとも1つの電磁放射は、約600nmと850nmの間の波長を有し、
前記光学機構は、約0.5と0.9の間の開口数を有し、
前記放射機構及び前記光学機構は、前記少なくとも1つの焦点領域内における前記少なくとも1つの電磁放射のフルエンスを約10J/cm2と1000J/cm2の間にするように構成される、
装置。 - 前記少なくとも1つの電磁放射の前記波長は、約625nmと約800nmの間である、請求項1記載の装置。
- 前記少なくとも1つの焦点領域の深さは、前記皮膚表面の下約120ミクロンと約400ミクロンの間である、請求項1記載の装置。
- 前記少なくとも1つの焦点領域の幅は、約200ミクロン未満である、請求項1記載の装置。
- 前記少なくとも1つの焦点領域の幅は、約50ミクロン未満である、請求項1記載の装置。
- 前記放射機構は、少なくとも1つのレーザダイオードを備える、請求項1記載の装置。
- 前記放射機構は、前記放射機構によって放出された前記少なくとも1つの電磁放射を前記光学機構上に誘導するように構成された導波路又は光ファイバのうちの少なくとも1つを備える、請求項1記載の装置。
- 前記少なくとも1つの焦点領域内における前記少なくとも1つの電磁放射の前記フルエンスは、約50J/cm2と500J/cm2の間である、請求項1記載の装置。
- 前記光学機構は、集束レンズ機構を備え、前記集束レンズ機構は、対物レンズ、凸レンズ、円柱レンズ、又は平凸レンズのうちの少なくとも1つを備える、請求項1記載の装置。
- 前記集束レンズ機構は、複数のレンズを備える、請求項9記載の装置。
- 前記レンズの各々の幅は、約1mmと3mmの間である、請求項10記載の装置。
- 前記レンズのうちの少なくとも2つは、異なる焦点距離を有する、請求項10記載の装置。
- 前記レンズのうちの少なくとも2つは、異なる開口数を有する、請求項10記載の装置。
- 前記レンズのうちの少なくとも2つは、異なる幅を有する、請求項10記載の装置。
- 前記集束レンズ機構の下面は、前記皮膚の前記表面上に配置されるように構成され構築される、請求項9記載の装置。
- 前記放射機構と通信するように設けられたセンサ機構をさらに備え、前記センサ機構は、前記皮膚組織の前記表面上の前記装置の平行移動速度を検出し、前記検出された速度に基づいて前記少なくとも1つの電磁放射の少なくとも1つの特性に影響を及ぼすための信号をもたらすように構成される、請求項1記載の装置。
- 前記放射機構又は前記光学機構のうちの少なくとも1つは、前記焦点領域内に供給される前記少なくとも1つの放射を、前記真皮層内の特定の位置に約2ミリ秒未満の継続時間の間誘導するように構成される、請求項1記載の装置。
- 前記放射機構又は前記光学機構のうちの少なくとも1つは、前記装置が前記皮膚組織の前記表面に対して静止した状態に保持されるとき、前記焦点領域内に供給される前記少なくとも1つの放射を前記真皮層内の複数の位置に移動させるように構成される、請求項1記載の装置。
- 真皮黒皮症の外見を改善する美容方法であって、
少なくとも1つの電磁放射を皮膚組織の真皮内の複数の位置に合焦させ適用するステップを含み、
前記少なくとも1つの電磁放射の波長は、約600nmと850nmの間であり、
前記少なくとも1つの電磁放射の焦点領域の幅は、約200ミクロン未満であり、
前記少なくとも1つの電磁放射は、約0.5と0.9の間の開口数を有するレンズ機構を用いて合焦され、
前記位置の各々に適用される前記少なくとも1つの放射のフルエンスは、約50J/cm2と1000J/cm2の間であり、
前記少なくとも1つの放射によって前記位置の各々に適用される局所照射時間は、約2ミリ秒未満である、
方法。 - 前記位置の深さは、前記皮膚組織の表面の下約120ミクロンと400ミクロンの間である、請求項19記載の方法。
- 前記少なくとも1つの電磁放射の前記波長は、約625nmと約800nmの間である、請求項19記載の方法。
- 前記焦点領域の幅は、約100ミクロン未満である、請求項19記載の方法。
- 前記焦点領域の幅は、約50ミクロン未満である、請求項19記載の方法。
- 前記少なくとも1つの電磁放射は、少なくとも1つのレーザダイオードによって供給される、請求項19記載の方法。
- 前記レンズ機構は、対物レンズ、凸レンズ、円柱レンズ、又は平凸レンズのうちの少なくとも1つを備える、請求項19記載の方法。
- 前記集束レンズ機構は、複数のレンズを備える、請求項19記載の方法。
- 前記レンズのうちの少なくとも2つは、異なる焦点距離、異なる開口数、及び異なる幅のうちの少なくとも1つを有する、請求項26記載の方法。
- 前記皮膚組織の表面に対して前記レンズ機構を平行移動させるステップをさらに含む、請求項19記載の方法。
- 前記皮膚組織の前記表面に対する前記レンズ機構の平行移動速度を検出するステップ、及び前記検出された速度に基づいて前記少なくとも1つの電磁放射の少なくとも1つの特性を変化させるステップをさらに含む、請求項28記載の方法。
- 皮膚組織の真皮内の色素沈着細胞を選択的に損傷する美容方法であって、
少なくとも1つの電磁放射を、前記色素沈着細胞を含む前記皮膚組織の特定の体積の内部に、それらを照射するべく合焦させるステップを含み、
前記少なくとも1つの電磁放射は、約600nmと850nmの間の波長を有し、
前記少なくとも1つの電磁放射の焦点領域の幅は、約200ミクロン未満であり、
照射の継続時間は、約2ミリ秒未満であり、
前記色素沈着細胞の近傍の非色素沈着細胞は損傷を受けず、それにより前記皮膚組織の前記真皮内の色素沈着細胞を選択的に損傷する、
方法。 - 前記少なくとも1つの合焦される放射の収束角は、約40度より大きい、請求項30記載の方法。
- 前記少なくとも1つの電磁放射の前記特定の体積内のフルエンスは、約50J/cm2と1000J/cm2の間である、請求項30記載の方法。
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US201361864238P | 2013-08-09 | 2013-08-09 | |
US61/864,238 | 2013-08-09 | ||
PCT/US2014/050518 WO2015021462A1 (en) | 2013-08-09 | 2014-08-11 | Method and apparatus for treating dermal melasma |
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EP3030186A1 (en) | 2016-06-15 |
US11039887B2 (en) | 2021-06-22 |
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US20200163714A1 (en) | 2020-05-28 |
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CN110840556B (zh) | 2023-05-26 |
CN110840556A (zh) | 2020-02-28 |
CN105530886A (zh) | 2016-04-27 |
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US11071587B2 (en) | 2021-07-27 |
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US20220022959A1 (en) | 2022-01-27 |
CA2920858A1 (en) | 2015-02-12 |
US20160199132A1 (en) | 2016-07-14 |
DK3030186T3 (en) | 2019-01-28 |
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