JP2016533323A - 多発性硬化症の治療のためのラキニモド併用療法 - Google Patents

多発性硬化症の治療のためのラキニモド併用療法 Download PDF

Info

Publication number
JP2016533323A
JP2016533323A JP2016516547A JP2016516547A JP2016533323A JP 2016533323 A JP2016533323 A JP 2016533323A JP 2016516547 A JP2016516547 A JP 2016516547A JP 2016516547 A JP2016516547 A JP 2016516547A JP 2016533323 A JP2016533323 A JP 2016533323A
Authority
JP
Japan
Prior art keywords
laquinimod
compound
formula
day
package
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
JP2016516547A
Other languages
English (en)
Japanese (ja)
Other versions
JP2016533323A5 (enExample
Inventor
ナパーツ、フォルカー
ケイ、ジョエル
Original Assignee
テバ ファーマシューティカル インダストリーズ リミティド
テバ ファーマシューティカル インダストリーズ リミティド
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by テバ ファーマシューティカル インダストリーズ リミティド, テバ ファーマシューティカル インダストリーズ リミティド filed Critical テバ ファーマシューティカル インダストリーズ リミティド
Publication of JP2016533323A publication Critical patent/JP2016533323A/ja
Publication of JP2016533323A5 publication Critical patent/JP2016533323A5/ja
Withdrawn legal-status Critical Current

Links

Images

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/16Amides, e.g. hydroxamic acids
    • A61K31/165Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A61K31/167Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/21Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/22Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
    • A61K31/225Polycarboxylic acids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47Quinolines; Isoquinolines
    • A61K31/47042-Quinolinones, e.g. carbostyril
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0014Skin, i.e. galenical aspects of topical compositions
    • A61K9/0017Non-human animal skin, e.g. pour-on, spot-on
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/007Pulmonary tract; Aromatherapy
    • A61K9/0073Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/10Dispersions; Emulsions
    • A61K9/12Aerosols; Foams
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/20Pills, tablets, discs, rods
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/48Preparations in capsules, e.g. of gelatin, of chocolate
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Emergency Medicine (AREA)
  • Dispersion Chemistry (AREA)
  • Pain & Pain Management (AREA)
  • Dermatology (AREA)
  • Zoology (AREA)
  • Otolaryngology (AREA)
  • Pulmonology (AREA)
  • Psychiatry (AREA)
  • Immunology (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Peptides Or Proteins (AREA)
  • Magnetic Resonance Imaging Apparatus (AREA)
JP2016516547A 2013-09-27 2014-09-26 多発性硬化症の治療のためのラキニモド併用療法 Withdrawn JP2016533323A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361883698P 2013-09-27 2013-09-27
US61/883,698 2013-09-27
PCT/US2014/057705 WO2015065628A2 (en) 2013-09-27 2014-09-26 Laquinimod combination therapy for treatment of multiple sclerosis

Publications (2)

Publication Number Publication Date
JP2016533323A true JP2016533323A (ja) 2016-10-27
JP2016533323A5 JP2016533323A5 (enExample) 2017-11-09

Family

ID=52740749

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2016516547A Withdrawn JP2016533323A (ja) 2013-09-27 2014-09-26 多発性硬化症の治療のためのラキニモド併用療法

Country Status (16)

Country Link
US (3) US20150094332A1 (enExample)
EP (1) EP3049075A4 (enExample)
JP (1) JP2016533323A (enExample)
KR (1) KR20160085757A (enExample)
CN (1) CN105848653A (enExample)
AR (1) AR097792A1 (enExample)
AU (1) AU2014342917A1 (enExample)
BR (1) BR112016006582A2 (enExample)
CA (1) CA2925493A1 (enExample)
EA (1) EA201690673A1 (enExample)
IL (1) IL244620A0 (enExample)
MX (1) MX2016003763A (enExample)
SG (1) SG11201602175VA (enExample)
TW (1) TW201601722A (enExample)
UY (1) UY35748A (enExample)
WO (1) WO2015065628A2 (enExample)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
UY36099A (es) 2014-04-29 2016-02-29 Teva Pharma Laquinimod para el tratamiento de pacientes con esclerosis múltiple remitente recurrente (rrms) con un alto grado de discapacidad

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19853487A1 (de) * 1998-11-19 2000-05-25 Fumapharm Ag Muri Verwendung von Dialkylfumaraten
WO2007006307A2 (en) * 2005-07-07 2007-01-18 Aditech Pharma Ab Novel salts of fumaric acid monoalkylesters and their pharmaceutical use
BRPI0713694A2 (pt) * 2006-06-12 2012-10-30 Teva Pharma composição farmacêutica, processo para preparar composição farmacêutica, embalagens vedada, métodos para tratar um indivìduo afligido com uma forma de esclerose múltipla, e para aliviar um sintoma de esclerose múltipla em um indivìduo afligido com uma forma de esclerose múltipla, e, uso da composição farmacêutica
CN107308162A (zh) * 2009-06-19 2017-11-03 泰华制药工业有限公司 利用拉喹莫德治疗多发性硬化
EP2736335A4 (en) * 2011-07-28 2015-01-07 Teva Pharma TREATMENT OF MULTIPLE SCLEROSIS USING A COMBINATION OF LAQUINIMOD AND GLATIRAMERATE ACETATE

Also Published As

Publication number Publication date
KR20160085757A (ko) 2016-07-18
CA2925493A1 (en) 2015-05-07
MX2016003763A (es) 2016-10-28
AR097792A1 (es) 2016-04-13
UY35748A (es) 2015-04-30
US20150094332A1 (en) 2015-04-02
IL244620A0 (en) 2016-04-21
US20170304253A1 (en) 2017-10-26
EP3049075A4 (en) 2017-05-03
WO2015065628A2 (en) 2015-05-07
AU2014342917A1 (en) 2016-04-21
US20160271094A1 (en) 2016-09-22
EP3049075A2 (en) 2016-08-03
EA201690673A1 (ru) 2016-08-31
WO2015065628A3 (en) 2015-10-29
CN105848653A (zh) 2016-08-10
BR112016006582A2 (pt) 2017-08-01
TW201601722A (zh) 2016-01-16
SG11201602175VA (en) 2016-04-28

Similar Documents

Publication Publication Date Title
JP2017137298A (ja) ラキニモドおよびフィンゴリモドを組み合わせた多発性硬化症の治療
JP2017081930A (ja) ラキニモドおよび酢酸グラチラマーを組み合わせた多発性硬化症の治療
JP2017061482A (ja) ラキニモドおよびインターフェロンβを組み合わせた多発性硬化症の治療
JP2017200927A (ja) ラキニモドおよびフマル酸ジメチルを併用した多発性硬化症の治療
TWI428130B (zh) 治療急性躁狂症之藥學組成物及方法
JP2015522077A (ja) ラキニモドおよびファムプリジンの組合せによる多発性硬化症の治療
WO2017048457A1 (en) Combination of laquinimod and pridopidine to treat multiple sclerosis
JP2016533323A (ja) 多発性硬化症の治療のためのラキニモド併用療法
US20180036302A1 (en) Treatment of multiple sclerosis with combination of laquinimod and a statin
JP2016527270A (ja) ラキニモドおよびフルピルチンの組合せによる多発性硬化症の治療
JP2017501230A (ja) ラキニモドおよびテリフルノミドの組合せを用いた多発性硬化症の治療
HK1225292A1 (en) Laquinimod combination therapy for treatment of multiple sclerosis
HK1229718A1 (en) Treatment of multiple sclerosis with combination of laquinimod and fingolimod
NZ621215B2 (en) Treatment of multiple sclerosis with combination of laquinimod and interferon-beta
TW201404395A (zh) 以拉喹莫德(laquinimod)及醋酸格拉替雷(glatiramer acetate)之組合治療多發性硬化症

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20170922

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20170922

A761 Written withdrawal of application

Free format text: JAPANESE INTERMEDIATE CODE: A761

Effective date: 20180329

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20180509