JP2016525697A5 - - Google Patents
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- Publication number
- JP2016525697A5 JP2016525697A5 JP2016531898A JP2016531898A JP2016525697A5 JP 2016525697 A5 JP2016525697 A5 JP 2016525697A5 JP 2016531898 A JP2016531898 A JP 2016531898A JP 2016531898 A JP2016531898 A JP 2016531898A JP 2016525697 A5 JP2016525697 A5 JP 2016525697A5
- Authority
- JP
- Japan
- Prior art keywords
- melanin
- sample
- melanin derivative
- derivative
- obtaining
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- XUMBMVFBXHLACL-UHFFFAOYSA-N Melanin Chemical class O=C1C(=O)C(C2=CNC3=C(C(C(=O)C4=C32)=O)C)=C2C4=CNC2=C1C XUMBMVFBXHLACL-UHFFFAOYSA-N 0.000 claims description 36
- 238000000034 method Methods 0.000 claims description 20
- 239000012620 biological material Substances 0.000 claims description 7
- UGSAVTSXHXRENH-UHFFFAOYSA-N 1h-pyrrole-2,3,5-tricarboxylic acid Chemical group OC(=O)C1=CC(C(O)=O)=C(C(O)=O)N1 UGSAVTSXHXRENH-UHFFFAOYSA-N 0.000 claims description 3
- 238000000622 liquid--liquid extraction Methods 0.000 claims description 2
- 238000004007 reversed phase HPLC Methods 0.000 claims description 2
- 238000000638 solvent extraction Methods 0.000 claims description 2
- 210000003491 skin Anatomy 0.000 claims 6
- 239000000853 adhesive Substances 0.000 claims 3
- 230000001070 adhesive effect Effects 0.000 claims 3
- 102000011782 Keratins Human genes 0.000 claims 1
- 108010076876 Keratins Proteins 0.000 claims 1
- 239000004820 Pressure-sensitive adhesive Substances 0.000 claims 1
- 210000004027 cell Anatomy 0.000 claims 1
- 239000002537 cosmetic Substances 0.000 claims 1
- 230000003810 hyperpigmentation Effects 0.000 claims 1
- 208000000069 hyperpigmentation Diseases 0.000 claims 1
- 210000002510 keratinocyte Anatomy 0.000 claims 1
- 230000036555 skin type Effects 0.000 claims 1
- 239000000758 substrate Substances 0.000 claims 1
- KKJUPNGICOCCDW-UHFFFAOYSA-N 7-N,N-Dimethylamino-1,2,3,4,5-pentathiocyclooctane Chemical compound CN(C)C1CSSSSSC1 KKJUPNGICOCCDW-UHFFFAOYSA-N 0.000 description 5
- YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 description 3
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 3
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 3
- 150000001875 compounds Chemical class 0.000 description 3
- HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 description 2
- MHAJPDPJQMAIIY-UHFFFAOYSA-N Hydrogen peroxide Chemical compound OO MHAJPDPJQMAIIY-UHFFFAOYSA-N 0.000 description 2
- 238000001514 detection method Methods 0.000 description 2
- VLKZOEOYAKHREP-UHFFFAOYSA-N n-Hexane Chemical compound CCCCCC VLKZOEOYAKHREP-UHFFFAOYSA-N 0.000 description 2
- 239000002904 solvent Substances 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- POGSZHUEECCEAP-ZETCQYMHSA-N (2s)-2-amino-3-(3-amino-4-hydroxyphenyl)propanoic acid Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C(N)=C1 POGSZHUEECCEAP-ZETCQYMHSA-N 0.000 description 1
- -1 4-amino-3-hydroxyphenyl Chemical group 0.000 description 1
- SXISMOAILJWTID-UHFFFAOYSA-N 5-S-cysteinyldopa Chemical compound OC(=O)C(N)CSC1=CC(CC(N)C(O)=O)=CC(O)=C1O SXISMOAILJWTID-UHFFFAOYSA-N 0.000 description 1
- OOOLUJRYYOCWMC-UHFFFAOYSA-N 6-hydroxy-5-methoxy-1h-indole-2-carboxylic acid Chemical compound C1=C(O)C(OC)=CC2=C1NC(C(O)=O)=C2 OOOLUJRYYOCWMC-UHFFFAOYSA-N 0.000 description 1
- BZLVMXJERCGZMT-UHFFFAOYSA-N Methyl tert-butyl ether Chemical compound COC(C)(C)C BZLVMXJERCGZMT-UHFFFAOYSA-N 0.000 description 1
- 239000012491 analyte Substances 0.000 description 1
- 238000004458 analytical method Methods 0.000 description 1
- NRIMHVFWRMABGJ-UHFFFAOYSA-N bicyclo[2.2.1]hepta-2,5-diene-2,3-dicarboxylic acid Chemical compound C1C2C(C(=O)O)=C(C(O)=O)C1C=C2 NRIMHVFWRMABGJ-UHFFFAOYSA-N 0.000 description 1
- 238000002144 chemical decomposition reaction Methods 0.000 description 1
- 238000004182 chemical digestion Methods 0.000 description 1
- 230000001066 destructive effect Effects 0.000 description 1
- 238000001976 enzyme digestion Methods 0.000 description 1
- 238000004128 high performance liquid chromatography Methods 0.000 description 1
- ZGEGCLOFRBLKSE-UHFFFAOYSA-N methylene hexane Natural products CCCCCC=C ZGEGCLOFRBLKSE-UHFFFAOYSA-N 0.000 description 1
- 238000009659 non-destructive testing Methods 0.000 description 1
- 239000002243 precursor Substances 0.000 description 1
- 230000035945 sensitivity Effects 0.000 description 1
- 210000004927 skin cell Anatomy 0.000 description 1
- 238000004885 tandem mass spectrometry Methods 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US13/957,278 US20150377751A1 (en) | 2013-08-01 | 2013-08-01 | Method of collecting and quantifying melanin in skin |
| US13/957,278 | 2013-08-01 | ||
| PCT/US2014/049142 WO2015017654A2 (en) | 2013-08-01 | 2014-07-31 | Method of collecting and quantifying melanin in skin |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2016525697A JP2016525697A (ja) | 2016-08-25 |
| JP2016525697A5 true JP2016525697A5 (https=) | 2017-07-20 |
Family
ID=51352865
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016531898A Pending JP2016525697A (ja) | 2013-08-01 | 2014-07-31 | 粘着剤を用いた皮膚中のメラニン収集及び定量の方法 |
Country Status (4)
| Country | Link |
|---|---|
| US (1) | US20150377751A1 (https=) |
| EP (1) | EP3028040B1 (https=) |
| JP (1) | JP2016525697A (https=) |
| WO (1) | WO2015017654A2 (https=) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BRPI0913578A2 (pt) | 2008-05-14 | 2017-06-06 | Dermtech Int | diagnose de melanoma e lentigo solar por análise de ácido nucléico |
| WO2019161126A1 (en) | 2018-02-14 | 2019-08-22 | Dermtech, Inc. | Novel gene classifiers and uses thereof in non-melanoma skin cancers |
| US20170296459A1 (en) * | 2016-04-14 | 2017-10-19 | The Procter & Gamble Company | Method of improving the appearance of periorbital dyschromia |
| US20170296456A1 (en) * | 2016-04-14 | 2017-10-19 | The Procter & Gamble Company | Products and methods for treating periorbital dyschromia |
| EP3649453A1 (en) * | 2017-07-03 | 2020-05-13 | The Procter and Gamble Company | Methods of measuring metal pollutants on skin |
| GB2576374A (en) * | 2018-08-17 | 2020-02-19 | Ecole Polytechnique Fed Lausanne Epfl | Skin cell analysis |
| JP7356326B2 (ja) * | 2019-11-01 | 2023-10-04 | 株式会社ナリス化粧品 | 皮膚成分の分析方法 |
| JP7356327B2 (ja) * | 2019-11-01 | 2023-10-04 | 株式会社ナリス化粧品 | 皮膚成分の採取用シートおよび皮膚成分の採取方法 |
| JP7574511B2 (ja) * | 2020-11-20 | 2024-10-29 | ポーラ化成工業株式会社 | シミ改善作用を有する成分のスクリーニング方法 |
| EP4346624A4 (en) * | 2021-06-04 | 2025-03-26 | Dermtech, Inc. | Sample collection system |
| JP7704336B2 (ja) * | 2021-09-15 | 2025-07-08 | 株式会社ファンケル | 角層の総タンパク量推定方法 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP3120087B2 (ja) * | 1992-02-12 | 2000-12-25 | 倉敷紡績株式会社 | 白髪の防止及び白髪黒色化用毛髪化粧料 |
| JP2000212037A (ja) * | 1999-01-26 | 2000-08-02 | Pola Chem Ind Inc | 化粧料の選択法 |
| KR101155194B1 (ko) * | 2006-03-31 | 2012-06-13 | (주)아모레퍼시픽 | 피부표면의 멜라닌 분포를 가시적으로 표현할 수 있는각질세포의 멜라닌을 정량하는 방법 |
| JP5176188B2 (ja) * | 2006-04-21 | 2013-04-03 | ディーエスエム アイピー アセッツ ビー．ブイ． | オピオイド受容体拮抗薬の使用 |
| JP5663141B2 (ja) * | 2009-02-26 | 2015-02-04 | 花王株式会社 | 皮膚色改変剤、毛色改変剤及びフェオメラニン産生促進剤 |
| JP5275898B2 (ja) * | 2009-05-21 | 2013-08-28 | ポーラ化成工業株式会社 | 皮膚状態の評価方法 |
| JP2011163944A (ja) * | 2010-02-10 | 2011-08-25 | Kao Corp | エストロゲンの定量方法 |
| JP5738720B2 (ja) * | 2011-03-24 | 2015-06-24 | 日本メナード化粧品株式会社 | メラニン合成能力評価方法及び美容アドバイス方法並びにそれらを用いるメラニン合成能力評価システム及び美容アドバイスシステム |
-
2013
- 2013-08-01 US US13/957,278 patent/US20150377751A1/en not_active Abandoned
-
2014
- 2014-07-31 EP EP14750947.5A patent/EP3028040B1/en active Active
- 2014-07-31 JP JP2016531898A patent/JP2016525697A/ja active Pending
- 2014-07-31 WO PCT/US2014/049142 patent/WO2015017654A2/en not_active Ceased
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