JP2016521114A5 - - Google Patents
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- Publication number
- JP2016521114A5 JP2016521114A5 JP2015562041A JP2015562041A JP2016521114A5 JP 2016521114 A5 JP2016521114 A5 JP 2016521114A5 JP 2015562041 A JP2015562041 A JP 2015562041A JP 2015562041 A JP2015562041 A JP 2015562041A JP 2016521114 A5 JP2016521114 A5 JP 2016521114A5
- Authority
- JP
- Japan
- Prior art keywords
- macrophages
- polypeptide
- differentiation
- expression
- activity
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 210000002540 macrophage Anatomy 0.000 claims description 12
- 150000001875 compounds Chemical class 0.000 claims description 9
- 229920001184 polypeptide Polymers 0.000 claims description 9
- 102000004196 processed proteins & peptides Human genes 0.000 claims description 9
- 108090000765 processed proteins & peptides Proteins 0.000 claims description 9
- 230000004069 differentiation Effects 0.000 claims description 7
- 230000000694 effects Effects 0.000 claims description 6
- 125000003275 alpha amino acid group Chemical group 0.000 claims description 3
- 210000004027 cell Anatomy 0.000 claims description 3
- 230000002401 inhibitory effect Effects 0.000 claims description 3
- 238000000034 method Methods 0.000 claims description 3
- 206010016654 Fibrosis Diseases 0.000 claims description 2
- 230000004761 fibrosis Effects 0.000 claims description 2
- 210000004322 M2 macrophage Anatomy 0.000 description 5
- 239000000126 substance Substances 0.000 description 2
- 239000000556 agonist Substances 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361781220P | 2013-03-14 | 2013-03-14 | |
| US61/781,220 | 2013-03-14 | ||
| PCT/EP2014/054441 WO2014139883A1 (en) | 2013-03-14 | 2014-03-07 | Molecular targets and compounds, and methods to identify the same, useful in the treatment of fibrotic diseases |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2016521114A JP2016521114A (ja) | 2016-07-21 |
| JP2016521114A5 true JP2016521114A5 (enExample) | 2017-04-06 |
| JP6437467B2 JP6437467B2 (ja) | 2018-12-19 |
Family
ID=50239627
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015562041A Active JP6437467B2 (ja) | 2013-03-14 | 2014-03-07 | 線維化疾患治療において有用な分子標的及び化合物、並びにこれらの同定方法 |
Country Status (4)
| Country | Link |
|---|---|
| US (2) | US20160054304A1 (enExample) |
| EP (1) | EP2972322B1 (enExample) |
| JP (1) | JP6437467B2 (enExample) |
| WO (1) | WO2014139883A1 (enExample) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2018149978A1 (en) * | 2017-02-16 | 2018-08-23 | MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. | ALTERNATIVE ACTIVATION OF MACROPHAGES (M2 CELLS) THROUGH THE POLYAMINE-eIF5a-HYPUSINE AXIS |
| US11536723B2 (en) | 2017-05-24 | 2022-12-27 | Mayo Foundation For Medical Education And Research | Integrated immunoassay |
| AU2018375151B2 (en) * | 2017-11-29 | 2025-06-26 | Spinalcyte Llc | Interaction of fibroblasts and immune cells for activation and uses thereof |
| AU2018438604A1 (en) * | 2018-08-29 | 2021-03-18 | Riptide Bioscience, Inc. | Peptides having immunomodulatory properties |
| GB201900724D0 (en) * | 2019-01-18 | 2019-03-06 | King S College London | Antibody |
| CA3123021A1 (en) | 2019-08-01 | 2021-02-04 | Illumina, Inc. | Flow cells |
| EP4018193A1 (en) | 2019-08-23 | 2022-06-29 | The Procter & Gamble Company | Method of identifying modulators of a fibrotic process |
| WO2021141733A1 (en) | 2020-01-07 | 2021-07-15 | The Procter & Gamble Company | Method of modulating a fibrotic condition |
| EP4213901A4 (en) * | 2020-09-21 | 2025-03-05 | Massachusetts Institute of Technology | COMPOUNDS, TARGETS AND PATHWAYS FOR MODULATION OF MACROPHAGES |
| CN117959323B (zh) * | 2024-01-12 | 2025-01-21 | 南方医科大学南方医院 | 环状rna在制备防治放射性肝纤维化的药物中的应用 |
Family Cites Families (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3773919A (en) | 1969-10-23 | 1973-11-20 | Du Pont | Polylactide-drug mixtures |
| US5354844A (en) | 1989-03-16 | 1994-10-11 | Boehringer Ingelheim International Gmbh | Protein-polycation conjugates |
| US5693622A (en) | 1989-03-21 | 1997-12-02 | Vical Incorporated | Expression of exogenous polynucleotide sequences cardiac muscle of a mammal |
| US5703055A (en) | 1989-03-21 | 1997-12-30 | Wisconsin Alumni Research Foundation | Generation of antibodies through lipid mediated DNA delivery |
| US5264618A (en) | 1990-04-19 | 1993-11-23 | Vical, Inc. | Cationic lipids for intracellular delivery of biologically active molecules |
| JPH07509133A (ja) | 1992-07-17 | 1995-10-12 | リボザイム・ファーマシューティカルズ・インコーポレイテッド | 動物疾患の処置のための方法および剤 |
| FR2714830B1 (fr) | 1994-01-10 | 1996-03-22 | Rhone Poulenc Rorer Sa | Composition contenant des acides nucléiques, préparation et utilisations. |
| FR2715847B1 (fr) | 1994-02-08 | 1996-04-12 | Rhone Poulenc Rorer Sa | Composition contenant des acides nucléiques, préparation et utilisations. |
| FR2727679B1 (fr) | 1994-12-05 | 1997-01-03 | Rhone Poulenc Rorer Sa | Nouveaux agents de transfection et leurs applications pharmaceutiques |
| FR2730637B1 (fr) | 1995-02-17 | 1997-03-28 | Rhone Poulenc Rorer Sa | Composition pharmaceutique contenant des acides nucleiques, et ses utilisations |
| GB9620749D0 (en) | 1996-10-04 | 1996-11-20 | Brax Genomics Ltd | Identifying antisense oligonucleotides |
| AU8280798A (en) | 1997-07-03 | 1999-01-25 | Thomas Jefferson University | An improved method for design and selection of efficacious antisense oligonucleotides |
| US6004753A (en) * | 1997-12-01 | 1999-12-21 | Incyte Pharmaceuticals, Inc. | Human S1-5 ECMP-like protein |
| GB2335035B (en) | 1998-03-03 | 2003-05-28 | Brax Genomics Ltd | Screening for functional antisense agents |
| US7332337B2 (en) | 2000-05-16 | 2008-02-19 | Galapagos Nv | Viral vectors having tissue tropism for T-lymphocytes, B- and mast cells |
| JP2004123539A (ja) * | 2001-03-13 | 2004-04-22 | Japan Tobacco Inc | 新規ピラゾロピリジン化合物及び医薬用途 |
| JP2004123537A (ja) * | 2000-06-20 | 2004-04-22 | Japan Tobacco Inc | ピラゾロピリジン化合物及びその医薬用途 |
| DE60138403D1 (de) | 2000-09-26 | 2009-05-28 | Crucell Holland Bv | Adenovirale vektoren für die übertragung von genen in zellen der skelettmuskulatur oder myoblasten |
| JP2005300158A (ja) * | 2001-03-26 | 2005-10-27 | Nippon Shinyaku Co Ltd | 増殖性糸球体腎炎の予防・治療用薬物のスクリーニング方法 |
| US20030198627A1 (en) | 2001-09-01 | 2003-10-23 | Gert-Jan Arts | siRNA knockout assay method and constructs |
| WO2004044587A2 (en) * | 2002-11-13 | 2004-05-27 | Bayer Healthcare Ag | Diagnostics and therapeutics for diseases associated with human endothelial differentiation, sphingolipid g-protein-coupled receptor 5 (edg5) |
| WO2004094636A1 (en) | 2003-04-24 | 2004-11-04 | Galapagos Genomics N.V. | Effective sirna knock-down constructs |
| WO2011087051A1 (ja) * | 2010-01-14 | 2011-07-21 | 国立大学法人金沢大学 | S1p2受容体アンタゴニストを含む粥状動脈硬化治療薬 |
| KR20130005086A (ko) * | 2011-07-05 | 2013-01-15 | 한국과학기술연구원 | 대장암 진단용 단백질 마커 피불린-4 및 이에 대한 항체를 포함하는 대장암 진단 키트 |
-
2014
- 2014-03-07 US US14/775,790 patent/US20160054304A1/en not_active Abandoned
- 2014-03-07 JP JP2015562041A patent/JP6437467B2/ja active Active
- 2014-03-07 WO PCT/EP2014/054441 patent/WO2014139883A1/en not_active Ceased
- 2014-03-07 EP EP14708865.2A patent/EP2972322B1/en active Active
-
2017
- 2017-08-04 US US15/669,213 patent/US10048250B2/en active Active
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