JP2016519138A5 - - Google Patents

Info

Publication number

JP2016519138A5

JP2016519138A5 JP2016512345A JP2016512345A JP2016519138A5 JP 2016519138 A5 JP2016519138 A5 JP 2016519138A5 JP 2016512345 A JP2016512345 A JP 2016512345A JP 2016512345 A JP2016512345 A JP 2016512345A JP 2016519138 A5 JP2016519138 A5 JP 2016519138A5

Authority

JP

Japan

Prior art keywords

pain

protein

tafa4

seq

use according

Prior art date

2014-05-06

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
• Global Dossier
• Discuss

• 101000788132 Homo sapiens Chemokine-like protein TAFA-4 Proteins 0.000 claims description 27
• 102100025944 Chemokine-like protein TAFA-4 Human genes 0.000 claims description 25
• 108090000623 proteins and genes Proteins 0.000 claims description 12
• 102000004169 proteins and genes Human genes 0.000 claims description 12
• 125000003275 alpha amino acid group Chemical group 0.000 claims description 7
• 210000000929 nociceptor Anatomy 0.000 claims description 7
• 108091008700 nociceptors Proteins 0.000 claims description 7
• 150000001875 compounds Chemical class 0.000 claims description 5
• 241001465754 Metazoa Species 0.000 claims description 2
• 208000002193 Pain Diseases 0.000 claims 10
• 230000036407 pain Effects 0.000 claims 8
• 208000004454 Hyperalgesia Diseases 0.000 claims 2
• 241000283984 Rodentia Species 0.000 claims 2
• 101150099849 Tafa4 gene Proteins 0.000 claims 2
• 208000004296 neuralgia Diseases 0.000 claims 2
• 208000021722 neuropathic pain Diseases 0.000 claims 2
• 208000000094 Chronic Pain Diseases 0.000 claims 1
• 208000035154 Hyperesthesia Diseases 0.000 claims 1
• 206010065390 Inflammatory pain Diseases 0.000 claims 1
• 241000124008 Mammalia Species 0.000 claims 1
• 208000028389 Nerve injury Diseases 0.000 claims 1
• 208000001294 Nociceptive Pain Diseases 0.000 claims 1
• 239000004480 active ingredient Substances 0.000 claims 1
• 208000005298 acute pain Diseases 0.000 claims 1
• 206010053552 allodynia Diseases 0.000 claims 1
• 230000036592 analgesia Effects 0.000 claims 1
• 230000003070 anti-hyperalgesia Effects 0.000 claims 1
• 239000003814 drug Substances 0.000 claims 1
• 239000003937 drug carrier Substances 0.000 claims 1
• 230000002779 inactivation Effects 0.000 claims 1
• 238000004519 manufacturing process Methods 0.000 claims 1
• 230000001404 mediated effect Effects 0.000 claims 1
• 230000008764 nerve damage Effects 0.000 claims 1
• 230000009261 transgenic effect Effects 0.000 claims 1
• 208000009935 visceral pain Diseases 0.000 claims 1
• 239000000556 agonist Substances 0.000 description 10
• 125000000539 amino acid group Chemical group 0.000 description 10
• 150000001413 amino acids Chemical class 0.000 description 7
• 239000012634 fragment Substances 0.000 description 6
• 210000001153 interneuron Anatomy 0.000 description 4
• 108020003175 receptors Proteins 0.000 description 4
• 102000039446 nucleic acids Human genes 0.000 description 3
• 108020004707 nucleic acids Proteins 0.000 description 3
• 150000007523 nucleic acids Chemical group 0.000 description 3
• 108090000765 processed proteins & peptides Proteins 0.000 description 3
• 210000003925 spinal cord interneuron Anatomy 0.000 description 3
• FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 description 2
• 101100424415 Mus musculus Tafa4 gene Proteins 0.000 description 2
• 108010033276 Peptide Fragments Proteins 0.000 description 2
• 102000007079 Peptide Fragments Human genes 0.000 description 2
• 210000004899 c-terminal region Anatomy 0.000 description 2
• 210000003169 central nervous system Anatomy 0.000 description 2
• 102000054241 human TAFA4 Human genes 0.000 description 2
• 230000001537 neural effect Effects 0.000 description 2
• 230000035945 sensitivity Effects 0.000 description 2
• 210000000278 spinal cord Anatomy 0.000 description 2
• 210000001170 unmyelinated nerve fiber Anatomy 0.000 description 2
• 108090000312 Calcium Channels Proteins 0.000 description 1
• 102000003922 Calcium Channels Human genes 0.000 description 1
• 108091005461 Nucleic proteins Chemical group 0.000 description 1
• 102000004257 Potassium Channel Human genes 0.000 description 1
• 108010076504 Protein Sorting Signals Proteins 0.000 description 1
• 238000004458 analytical method Methods 0.000 description 1
• 230000000694 effects Effects 0.000 description 1
• 230000005284 excitation Effects 0.000 description 1
• 108020004999 messenger RNA Proteins 0.000 description 1
• 239000002773 nucleotide Substances 0.000 description 1
• 125000003729 nucleotide group Chemical group 0.000 description 1
• 108020001213 potassium channel Proteins 0.000 description 1
• 239000002243 precursor Substances 0.000 description 1
• 238000011002 quantification Methods 0.000 description 1
• 238000003753 real-time PCR Methods 0.000 description 1
• 102000005962 receptors Human genes 0.000 description 1
• 210000001103 thalamus Anatomy 0.000 description 1