JP2016505353A5 - - Google Patents
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- Publication number
- JP2016505353A5 JP2016505353A5 JP2015541741A JP2015541741A JP2016505353A5 JP 2016505353 A5 JP2016505353 A5 JP 2016505353A5 JP 2015541741 A JP2015541741 A JP 2015541741A JP 2015541741 A JP2015541741 A JP 2015541741A JP 2016505353 A5 JP2016505353 A5 JP 2016505353A5
- Authority
- JP
- Japan
- Prior art keywords
- substituted
- ring structure
- separation matrix
- unsubstituted
- separation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 238000000926 separation method Methods 0.000 claims 15
- 239000011159 matrix material Substances 0.000 claims 12
- 150000001875 compounds Chemical class 0.000 claims 4
- -1 hydroxypropyl group Chemical group 0.000 claims 4
- 239000003446 ligand Substances 0.000 claims 4
- 239000007858 starting material Substances 0.000 claims 4
- 150000003512 tertiary amines Chemical class 0.000 claims 4
- 238000000034 method Methods 0.000 claims 3
- 125000001570 methylene group Chemical group [H]C([H])([*:1])[*:2] 0.000 claims 3
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 3
- 239000002262 Schiff base Substances 0.000 claims 2
- 150000004753 Schiff bases Chemical class 0.000 claims 2
- 125000003277 amino group Chemical group 0.000 claims 2
- NBVXSUQYWXRMNV-UHFFFAOYSA-N fluoromethane Chemical group FC NBVXSUQYWXRMNV-UHFFFAOYSA-N 0.000 claims 2
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 2
- 125000006850 spacer group Chemical group 0.000 claims 2
- GAWIXWVDTYZWAW-UHFFFAOYSA-N C[CH]O Chemical group C[CH]O GAWIXWVDTYZWAW-UHFFFAOYSA-N 0.000 claims 1
- 102000008394 Immunoglobulin Fragments Human genes 0.000 claims 1
- 108010021625 Immunoglobulin Fragments Proteins 0.000 claims 1
- OPKOKAMJFNKNAS-UHFFFAOYSA-N N-methylethanolamine Chemical compound CNCCO OPKOKAMJFNKNAS-UHFFFAOYSA-N 0.000 claims 1
- YTPLMLYBLZKORZ-UHFFFAOYSA-N Thiophene Chemical group C=1C=CSC=1 YTPLMLYBLZKORZ-UHFFFAOYSA-N 0.000 claims 1
- 125000001931 aliphatic group Chemical group 0.000 claims 1
- 125000003118 aryl group Chemical group 0.000 claims 1
- 125000004432 carbon atom Chemical group C* 0.000 claims 1
- 239000003153 chemical reaction reagent Substances 0.000 claims 1
- 229940125773 compound 10 Drugs 0.000 claims 1
- 125000000113 cyclohexyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 claims 1
- 239000012039 electrophile Substances 0.000 claims 1
- 125000001033 ether group Chemical group 0.000 claims 1
- 125000002485 formyl group Chemical group [H]C(*)=O 0.000 claims 1
- 102000037865 fusion proteins Human genes 0.000 claims 1
- 108020001507 fusion proteins Proteins 0.000 claims 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 1
- ZLVXBBHTMQJRSX-VMGNSXQWSA-N jdtic Chemical compound C1([C@]2(C)CCN(C[C@@H]2C)C[C@H](C(C)C)NC(=O)[C@@H]2NCC3=CC(O)=CC=C3C2)=CC=CC(O)=C1 ZLVXBBHTMQJRSX-VMGNSXQWSA-N 0.000 claims 1
- 239000007788 liquid Substances 0.000 claims 1
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 claims 1
- RIWRFSMVIUAEBX-UHFFFAOYSA-N n-methyl-1-phenylmethanamine Chemical compound CNCC1=CC=CC=C1 RIWRFSMVIUAEBX-UHFFFAOYSA-N 0.000 claims 1
- HGASFNYMVGEKTF-UHFFFAOYSA-N octan-1-ol;hydrate Chemical compound O.CCCCCCCCO HGASFNYMVGEKTF-UHFFFAOYSA-N 0.000 claims 1
- 238000005192 partition Methods 0.000 claims 1
- 102000004169 proteins and genes Human genes 0.000 claims 1
- 108090000623 proteins and genes Proteins 0.000 claims 1
- 150000003335 secondary amines Chemical class 0.000 claims 1
- 125000001424 substituent group Chemical group 0.000 claims 1
- 230000002194 synthesizing effect Effects 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE1251286-9 | 2012-11-13 | ||
| SE1251286 | 2012-11-13 | ||
| PCT/SE2013/051325 WO2014077762A1 (en) | 2012-11-13 | 2013-11-11 | Multimodal anion exchange matrices |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2016505353A JP2016505353A (ja) | 2016-02-25 |
| JP2016505353A5 true JP2016505353A5 (cg-RX-API-DMAC7.html) | 2016-12-22 |
| JP6397422B2 JP6397422B2 (ja) | 2018-09-26 |
Family
ID=50731539
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015541741A Active JP6397422B2 (ja) | 2012-11-13 | 2013-11-11 | マルチモーダルアニオン交換マトリックス |
Country Status (6)
| Country | Link |
|---|---|
| US (2) | US11718643B2 (cg-RX-API-DMAC7.html) |
| EP (1) | EP2919902B1 (cg-RX-API-DMAC7.html) |
| JP (1) | JP6397422B2 (cg-RX-API-DMAC7.html) |
| CN (1) | CN104797332B (cg-RX-API-DMAC7.html) |
| IN (1) | IN2015DN03308A (cg-RX-API-DMAC7.html) |
| WO (1) | WO2014077762A1 (cg-RX-API-DMAC7.html) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IN2015DN03308A (cg-RX-API-DMAC7.html) | 2012-11-13 | 2015-10-09 | Ge Healthcare Bio Sciences Ab | |
| PL2970378T3 (pl) | 2013-03-15 | 2021-12-06 | Biogen Ma Inc. | Chromatografia oddziaływań hydrofobowych białek w warunkach bez soli |
| JP6542388B2 (ja) * | 2015-12-25 | 2019-07-10 | 信和化工株式会社 | クロマトグラフィー用分離剤、クロマトグラフィーカラム、及びクロマトグラフィーによる分離方法 |
| US10864512B2 (en) * | 2016-04-06 | 2020-12-15 | Cytiva Bioprocess R&D Ab | Chromatography matrix |
| WO2018048696A1 (en) | 2016-09-09 | 2018-03-15 | 3M Innovative Properties Company | Functionalized copolymers and use thereof |
| US12181452B2 (en) | 2017-09-18 | 2024-12-31 | Waters Technologies Corporation | Use of vapor deposition coated flow paths for improved chromatography of metal interacting analytes |
| US11709155B2 (en) | 2017-09-18 | 2023-07-25 | Waters Technologies Corporation | Use of vapor deposition coated flow paths for improved chromatography of metal interacting analytes |
| US11709156B2 (en) | 2017-09-18 | 2023-07-25 | Waters Technologies Corporation | Use of vapor deposition coated flow paths for improved analytical analysis |
| US12180581B2 (en) | 2017-09-18 | 2024-12-31 | Waters Technologies Corporation | Use of vapor deposition coated flow paths for improved chromatography of metal interacting analytes |
| US11666888B2 (en) * | 2018-02-05 | 2023-06-06 | Bio-Rad Laboratories, Inc. | Chromatography resin having an anionic exchange-hydrophobic mixed mode ligand |
| EP3762120A4 (en) | 2018-03-08 | 2021-09-01 | Bio-Rad Laboratories, Inc. | MIXED MODE ANIONIC-HYDROPHOBIC EXCHANGE CHROMATOGRAPHY RESIN |
| JP7717627B2 (ja) | 2019-09-05 | 2025-08-04 | バイオ－ラッド・ラボラトリーズ・インコーポレーテッド | アニオン交換－疎水性混合モードクロマトグラフィー樹脂 |
| US20210138361A1 (en) * | 2019-11-07 | 2021-05-13 | Waters Technologies Corporation | Materials and methods for mixed mode, anion exchange reversed phase liquid chromatography |
| US11918936B2 (en) | 2020-01-17 | 2024-03-05 | Waters Technologies Corporation | Performance and dynamic range for oligonucleotide bioanalysis through reduction of non specific binding |
| GB202006231D0 (en) | 2020-04-28 | 2020-06-10 | Puridify Ltd | Seperation matrix and metod for seperation |
| US12352734B2 (en) | 2020-09-24 | 2025-07-08 | Waters Technologies Corporation | Chromatographic hardware improvements for separation of reactive molecules |
| CA3201649A1 (en) * | 2020-12-10 | 2022-06-16 | Zeev DVASHI | Extracorporeal device and matrix for removing ammonia from biological fluids, methods and uses thereof |
| EP4416166A4 (en) * | 2021-10-15 | 2025-10-22 | Bio Rad Laboratories Inc | MIXED-MODE CATION EXCHANGE CHROMATOGRAPHY LIGANDS BASED ON 2-BENZAMIDO-SUBSTITUTED ACETIC ACID STRUCTURES |
| CN116262222B (zh) * | 2023-01-09 | 2024-07-30 | 浙江纽龙合成材料制造有限公司 | 一种二乙氨基乙基天然多糖层析介质的制备方法 |
| CN121194823A (zh) * | 2023-03-26 | 2025-12-23 | 利默蛋白质解决方案私人有限责任公司 | 用于精制过程的新材料和方法 |
| CN116351103B (zh) * | 2023-03-31 | 2025-09-16 | 百林科(兰州)新材料有限公司 | 一种层析介质及其制备方法和应用 |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4043997A (en) * | 1976-05-28 | 1977-08-23 | Cutter Laboratories, Inc. | Method for isolating albumin using insoluble supports coupled to a dye |
| FR2543448A1 (fr) * | 1983-04-01 | 1984-10-05 | Rhone Poulenc Spec Chim | Procede de fractionnement du plasma |
| GB2221466A (en) * | 1988-03-09 | 1990-02-07 | Aluminum Co Of America | Biologically reactive particles with biological, therapeutic and chromatographic applications |
| SE9601368D0 (sv) | 1996-04-11 | 1996-04-11 | Pharmacia Biotech Ab | Process for the production of a porous cross-linked polysaccharide gel |
| ES2332893T3 (es) | 1996-08-30 | 2010-02-15 | Upfront Chromatography A/S | Aislamiento de inmunoglobulinas. |
| SE9700383D0 (sv) | 1997-02-04 | 1997-02-04 | Pharmacia Biotech Ab | An adsorption/separation method and a medium for adsorption/separation |
| SE0402558D0 (sv) * | 2004-10-21 | 2004-10-21 | Amersham Biosciences Ab | A process for the purification of antibodies |
| SE0400501D0 (sv) | 2004-02-27 | 2004-02-27 | Amersham Biosciences Ab | Antibody purification |
| NZ548126A (en) | 2004-02-27 | 2009-10-30 | Ge Healthcare Bio Sciences Ab | A process for the purification of antibodies involving addition of a second resin |
| EP1807205B1 (en) | 2004-10-21 | 2012-09-26 | GE Healthcare Bio-Sciences AB | A method of antibody purification |
| MX2007007703A (es) * | 2004-12-23 | 2007-08-14 | Novo Nordisk As | Ligandos de afinidad de union a anticuerpos. |
| TW200639190A (en) | 2005-02-04 | 2006-11-16 | Showa Denko Kk | Packing material for ion chromatography |
| GT200600042A (es) * | 2005-02-10 | 2006-09-27 | Aventis Pharma Inc | Compuestos de bis arilo y heteroarilo sustituido como antagonistas selectivos de 5ht2a |
| GB0509443D0 (en) * | 2005-05-09 | 2005-06-15 | Prometic Biosciences Ltd | Affinity adsorbents for factor VIII and von willebrand's factor |
| WO2010030222A1 (en) * | 2008-09-12 | 2010-03-18 | Ge Healthcare Bio-Sciences Ab | Enhanced protein aggregate removal with multimodal anion exchangers in the presence of protein-excluded zwitterions |
| US8277649B2 (en) * | 2009-12-14 | 2012-10-02 | General Electric Company | Membranes and associated methods for purification of antibodies |
| IN2015DN03308A (cg-RX-API-DMAC7.html) | 2012-11-13 | 2015-10-09 | Ge Healthcare Bio Sciences Ab |
-
2013
- 2013-11-11 IN IN3308DEN2015 patent/IN2015DN03308A/en unknown
- 2013-11-11 WO PCT/SE2013/051325 patent/WO2014077762A1/en not_active Ceased
- 2013-11-11 JP JP2015541741A patent/JP6397422B2/ja active Active
- 2013-11-11 EP EP13854329.3A patent/EP2919902B1/en active Active
- 2013-11-11 US US14/441,129 patent/US11718643B2/en active Active
- 2013-11-11 CN CN201380059124.0A patent/CN104797332B/zh active Active
-
2018
- 2018-08-29 US US16/115,756 patent/US10815269B2/en active Active
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