JP2016502523A5 - - Google Patents

Info

Publication number

JP2016502523A5

JP2016502523A5 JP2015542272A JP2015542272A JP2016502523A5 JP 2016502523 A5 JP2016502523 A5 JP 2016502523A5 JP 2015542272 A JP2015542272 A JP 2015542272A JP 2015542272 A JP2015542272 A JP 2015542272A JP 2016502523 A5 JP2016502523 A5 JP 2016502523A5

Authority

JP

Japan

Prior art keywords

use according

human mammal

rfsh

analog

human

Prior art date

2013-11-15

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
• Global Dossier
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• 241000283690 Bos taurus Species 0.000 claims 9
• 230000003325 follicular Effects 0.000 claims 7
• 108090000765 processed proteins & peptides Proteins 0.000 claims 6
• 230000001850 reproductive effect Effects 0.000 claims 6
• 230000009027 insemination Effects 0.000 claims 5
• 238000000034 method Methods 0.000 claims 5
• 230000016087 ovulation Effects 0.000 claims 5
• 239000000583 progesterone congener Substances 0.000 claims 4
• 150000003180 prostaglandins Chemical class 0.000 claims 4
• WAHQVRCNDCHDIB-QZYSPNBYSA-N [(3s,8r,9s,10r,13s,14s,17r)-17-acetyl-17-acetyloxy-6,10,13-trimethyl-1,2,3,8,9,11,12,14,15,16-decahydrocyclopenta[a]phenanthren-3-yl] 3-cyclopentylpropanoate Chemical compound O([C@@H]1C=C2C(C)=C[C@H]3[C@@H]4CC[C@]([C@]4(CC[C@@H]3[C@@]2(C)CC1)C)(OC(=O)C)C(C)=O)C(=O)CCC1CCCC1 WAHQVRCNDCHDIB-QZYSPNBYSA-N 0.000 claims 3
• 238000002347 injection Methods 0.000 claims 3
• 239000007924 injection Substances 0.000 claims 3
• 239000000203 mixture Substances 0.000 claims 3
• 210000000287 oocyte Anatomy 0.000 claims 3
• 101800005309 Carboxy-terminal peptide Proteins 0.000 claims 2
• NMJREATYWWNIKX-UHFFFAOYSA-N GnRH Chemical compound C1CCC(C(=O)NCC(N)=O)N1C(=O)C(CC(C)C)NC(=O)C(CC=1C2=CC=CC=C2NC=1)NC(=O)CNC(=O)C(NC(=O)C(CO)NC(=O)C(CC=1C2=CC=CC=C2NC=1)NC(=O)C(CC=1NC=NC=1)NC(=O)C1NC(=O)CC1)CC1=CC=C(O)C=C1 NMJREATYWWNIKX-UHFFFAOYSA-N 0.000 claims 2
• 241001465754 Metazoa Species 0.000 claims 2
• 101000857870 Squalus acanthias Gonadoliberin Proteins 0.000 claims 2
• 238000010255 intramuscular injection Methods 0.000 claims 2
• 239000007927 intramuscular injection Substances 0.000 claims 2
• 229920001184 polypeptide Polymers 0.000 claims 2
• 102000004196 processed proteins & peptides Human genes 0.000 claims 2
• PXGPLTODNUVGFL-BRIYLRKRSA-N (E,Z)-(1R,2R,3R,5S)-7-(3,5-Dihydroxy-2-((3S)-(3-hydroxy-1-octenyl))cyclopentyl)-5-heptenoic acid Chemical compound CCCCC[C@H](O)C=C[C@H]1[C@H](O)C[C@H](O)[C@@H]1CC=CCCCC(O)=O PXGPLTODNUVGFL-BRIYLRKRSA-N 0.000 claims 1
• FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 1
• 102000011022 Chorionic Gonadotropin Human genes 0.000 claims 1
• 108010062540 Chorionic Gonadotropin Proteins 0.000 claims 1
• 241000283086 Equidae Species 0.000 claims 1
• 241000124008 Mammalia Species 0.000 claims 1
• 241001494479 Pecora Species 0.000 claims 1
• 206010042573 Superovulation Diseases 0.000 claims 1
• 238000002679 ablation Methods 0.000 claims 1
• 102000002287 alpha Subunit Glycoprotein Hormones Human genes 0.000 claims 1
• 108010000732 alpha Subunit Glycoprotein Hormones Proteins 0.000 claims 1
• 125000003275 alpha amino acid group Chemical group 0.000 claims 1
• 102000035824 beta Subunit Follicle Stimulating Hormone Human genes 0.000 claims 1
• 108010081485 beta Subunit Follicle Stimulating Hormone Proteins 0.000 claims 1
• 239000000969 carrier Substances 0.000 claims 1
• 244000144980 herd Species 0.000 claims 1
• 230000003054 hormonal effect Effects 0.000 claims 1
• 229940084986 human chorionic gonadotropin Drugs 0.000 claims 1
• 230000001939 inductive effect Effects 0.000 claims 1
• 238000007918 intramuscular administration Methods 0.000 claims 1
• 229940094443 oxytocics prostaglandins Drugs 0.000 claims 1
• 239000000546 pharmaceutical excipient Substances 0.000 claims 1
• 230000035935 pregnancy Effects 0.000 claims 1
• 241000894007 species Species 0.000 claims 1
• 238000007910 systemic administration Methods 0.000 claims 1