JP2016175871A - Aqueous gel cosmetics - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide aqueous gel cosmetics containing astaxanthin in which locally generating concentration change part of gel cosmetics with passage of time is inhibited.SOLUTION: An aqueous gel cosmetic contains, to the total amount of the cosmetic, 1-100 ppm of astaxanthin, 1-10 mass% of trimethylglycine, and 0.5-5 mass% of a compound represented by general formula (1), wherein the total content of the element selected from Na and K to the total amount of the cosmetic is 0.05 mass% or more. In the general formula (1), R: a hydrocarbon group, R, R: a hydrocarbon group, R: an h+1 valent hydrocarbon group, R: a hydrocarbon group, R: a hydrogen atom or the like, m: 2 or more, h: 1 or more, and k and n: 0-1000.SELECTED DRAWING: None

Description

  The present invention relates to an aqueous gel cosmetic.

  In the fields of cosmetics, foods, pharmaceuticals and the like, gelling agents are widely used to impart viscosity or elasticity to products. For example, in the cosmetics field, a gelling agent is used for the purpose of enhancing the feeling of use when applied to the skin or preventing dripping, etc., and imparting a unique viscosity or elasticity to the product. Yes.

  There has been reported a skin whitening external preparation for whitening which takes the form of a jelly-like cosmetic containing a gelling agent containing a whitening agent and an associative polymer having a specific structure, which has moisture retention and has reduced stickiness ( For example, see Patent Document 1).

  As active ingredients contained in cosmetics, lycopene and astaxanthin, which are fat-soluble carotenoid pigments, are attracting attention from the viewpoint of antioxidant properties, and a topical skin preparation containing carotenoids and pterostilbene has been proposed. (For example, refer to Patent Document 2).

  On the other hand, it is known that carotenoid pigments are easily oxidized by light or heat, and various methods for stabilizing carotenoid pigments have been studied. For example, a lycopene-containing composition that contains lycopene, which is a kind of carotenoid pigment, and propynyl butylcarbamate, has sufficient antiseptic properties, can be stably formulated with lycopene, and can be applied to cosmetics. Is known (see, for example, Patent Document 3).

JP 2002-284664 A JP 2013-227275 A JP 2013-199466 A

By the way, astaxanthin, which is a carotenoid pigment having an excellent antioxidant function, exhibits a unique red color, and therefore, when blended in a gel cosmetic, it can be made into a cosmetic having an excellent appearance in addition to the function as an active ingredient. it can.
On the other hand, since astaxanthin does not dissolve in water and has low solubility in oily components, when astaxanthin is blended in cosmetics, it may be difficult to ensure stability as a cosmetic.
According to the study by the present inventors, for example, it is possible to disperse astaxanthin using an oily component, a surfactant, and the like, and blend it in a gel cosmetic as a dispersion. However, when astaxanthin is blended into a transparent gel cosmetic, it is known that local concentration variation may occur when stored for a long period of time due to the effects of various ingredients to ensure gel strength. It was.

  An object of the present invention is to provide an aqueous gel cosmetic that suppresses the uneven distribution of astaxanthin over time in a gel cosmetic containing astaxanthin.

  Specific means for solving the above problems include the following embodiments.

[1] Astaxanthin, trimethylglycine and the compound represented by the following general formula (1) are contained in the following content with respect to the total amount of the aqueous gel cosmetic and are selected from Na and K relative to the total amount of the aqueous gel cosmetic. An aqueous gel cosmetic having a total element content of 0.05% by mass or more.
Astaxanthin: 1 ppm to 100 ppm
Trimethylglycine: 1% to 10% by mass
Compound represented by the following general formula (1): 0.5% by mass to 5% by mass

In the general formula (1), R ¹ represents an m-valent hydrocarbon group having ² to 36 carbon atoms, R ² and R ⁴ each independently represents a divalent hydrocarbon group having 1 to 4 carbon atoms, R ³ represents a straight chain, branched chain, or h + 1 valent hydrocarbon group containing an aliphatic ring or an aromatic ring, which may have a urethane bond, R ⁵ represents a divalent hydrocarbon group, and R ⁶ represents Represents a hydrogen atom or a hydroxy group. m is an integer greater than or equal to 2, h is an integer greater than or equal to 1, k and n represent the repeating number of the structure in a parenthesis, and are each independently an integer of the range of 0-1000, both k and n Will never be zero.

[2] The aqueous gel cosmetic according to [1], wherein the content of astaxanthin relative to the total amount of the aqueous gel cosmetic is 10 ppm to 100 ppm.
[3] Contains at least one compound selected from the group consisting of trisodium ascorbyl palmitate, sodium tocopheryl phosphate, sodium isostearate, potassium isostearate, sodium oleate, and potassium oleate [1] Or the aqueous gel cosmetics as described in [2].
[4] The aqueous gel cosmetic according to any one of [1] to [3], which contains at least one compound selected from the group consisting of citrate and phosphate.
[5] The aqueous gel cosmetic according to [4], which contains at least one compound selected from phosphates.

  ADVANTAGE OF THE INVENTION According to this invention, in the gel cosmetics containing astaxanthin, the aqueous gel cosmetics by which the uneven distribution of astaxanthin with time can be suppressed can be provided.

  Hereinafter, specific embodiments of the present invention will be described in detail. However, the present invention is not limited to the following embodiments, and can be implemented with appropriate modifications within the scope of the object of the present invention. .

In the present specification, a numerical range indicated using “to” means a range including the numerical values described before and after “to” as the minimum value and the maximum value, respectively.
In the present specification, the amount of each component in the aqueous gel cosmetic is such that when there are a plurality of substances corresponding to each component in the aqueous gel cosmetic, unless otherwise specified, Means the total amount of a plurality of substances present in

In this specification, the term “aqueous phase” is used as a term for “oil phase” regardless of the type of solvent.
In this specification, the term “process” is not limited to an independent process, and is included in this term if the intended purpose of the process is achieved even when it cannot be clearly distinguished from other processes. It is.

The “aqueous gel cosmetic” of the present invention includes a hydrogel, and preferably has a total content of water and, if desired, a water-soluble liquid component of 50% by mass or more, and is soluble in water at 25 ° C. The amount of the liquid component whose amount is 1% by mass or less is a cosmetic that is 10% by mass or less with respect to the total mass of the cosmetic.
The “water-soluble liquid component” as used herein refers to a liquid component in which the amount of the target substance dissolved in water at 25 ° C. exceeds 1% by mass.

  “Suppressing the uneven distribution of astaxanthin”, which is an effect of the present invention, means preventing a phenomenon in which the concentration of astaxanthin in the aqueous gel cosmetic is locally increased. Suppressing the uneven distribution of astaxanthin over time is synonymous with maintaining the transparency of the aqueous gel cosmetic over time, and is synonymous with maintaining the stability of the aqueous gel cosmetic over time. .

[Aqueous gel cosmetics]
The aqueous gel cosmetic of the present invention (hereinafter appropriately referred to as “gel cosmetic”) is a compound represented by astaxanthin, trimethylglycine (hereinafter appropriately referred to as “TMG”) and general formula (1). (Hereinafter referred to as “specific compound (1)” as appropriate) with the following content relative to the total amount of the aqueous gel cosmetic, and the total content of elements selected from Na and K relative to the total amount of the aqueous gel cosmetic It is an aqueous gel cosmetic which has an amount of 0.05% by mass or more.
Astaxanthin: 1 ppm to 100 ppm
Trimethylglycine: 1% to 10% by mass
Compound represented by general formula (1): 0.5% by mass to 5% by mass
The aqueous gel cosmetic of the present invention may contain other components other than astaxanthin, TMG, and the specific compound (1) as necessary, as long as the effects of the present invention are not impaired.

  The aqueous gel cosmetic of the present invention has a gel-like dosage form with excellent appearance, and contains 0.5% by mass to 5% by mass of the specific compound (1) with respect to the total amount of the gel cosmetic. As is clear from the general formula (1), the specific compound (1) has a urethane structure and a hydrophilic hydrocarbon oxy group in the main chain, and has a hydrophobic hydrocarbon group at the terminal, and is modified to be hydrophobic. Urethane-based copolymer, which is useful for forming a gel-like dosage form.

It has been revealed that the pH stability and gel hardness stability of the gel are improved by containing a cation selected from Na cation and K cation. On the other hand, when the content of a cation selected from Na cation and K cation increases in the gel cosmetic, the stability of the gel increases, but in the uniform transparent gel cosmetic containing astaxanthin, the aging more than the surroundings over time. A portion with a high color density or a portion that appears cloudy may occur. According to the analysis, it was found that the part having a higher color density than the periphery or the part that appears cloudy is due to the uneven distribution of astaxanthin in the gel cosmetic.
For example, when astaxanthin is contained as a fine oil phase of an oil-in-water emulsion contained in a gel cosmetic, the oil phase containing astaxanthin aggregates, resulting in a portion having a higher color density than the surroundings. Furthermore, when medium chain fatty acids are contained in the oil phase containing astaxanthin, the medium chain fatty acids may aggregate together with astaxanthin, resulting in areas with high color density or areas that appear cloudy. There is.

  In the present invention, it has been found that the uneven distribution of astaxanthin is suppressed by containing a predetermined amount of trimethylglycine. When a normal betaine-type surfactant is used, astaxanthin uneven distribution suppression is not recognized, and the astaxanthin uneven distribution suppression effect is considered to be a unique effect derived from the inclusion of trimethylglycine.

In the aqueous gel cosmetic of the present invention, astaxanthin and the specific compound (1) having a hydrophobic part and a hydrophilic part in the molecule are included in specific amounts, respectively, and Na element and K contained in the total amount of the gel cosmetics In gel cosmetics with an element content of 0.05% by mass or more, by containing a specific amount of trimethylglycine, stability over time, in particular, local concentration change over time is suppressed, and good appearance It is considered that an aqueous gel-like cosmetic containing astaxanthin that can be maintained for a long time can be realized.
In addition, the said estimation does not interpret the effect of this invention restrictively, but demonstrates it as an example.

  Hereinafter, each component contained in the aqueous gel cosmetic of the present invention will be described in detail.

[Trimethylglycine: TMG]
The gel cosmetic of the present invention contains 1% by mass to 10% by mass of trimethylglycine with respect to the total amount of the gel cosmetic.
Trimethylglycine is a compound having the structure shown below, and may be referred to as glycine betaine, anhydrous betaine, or simply betaine.
Trimethylglycine is an organic compound that exists in many living organisms. Trimethylglycine can be obtained by extraction and purification from sugar beet molasses.
Trimethylglycine is also available as a commercial product, and examples thereof include Asahi Kasei Chemicals Corporation, Amicoat (trade name), Ebisu Chemical Co., Ltd., Betafin BP (trade name), and the like.

When the content of trimethylglycine is less than 1% by mass, the uneven distribution suppressing effect of astaxanthin may not be sufficiently obtained.
On the other hand, when the content of trimethylglycine exceeds 10% by mass, the effect of suppressing the uneven distribution of astaxanthin in the gel cosmetic does not improve any more. On the other hand, the touch after application and drying is refreshed. There may be a case where a feeling of moisturizing on the skin and a feeling of continuous moisturizing cannot be sufficiently felt.

  The content of trimethylglycine with respect to the total amount of the gel cosmetic is preferably 2% by mass to 10% by mass, and more preferably 3% by mass to 5% by mass.

[Compound represented by general formula (1): Specific compound (1)]
The aqueous gel cosmetic of the present invention contains a compound represented by the following general formula (1) (specific compound (1)).

In the general formula (1), R ¹ represents an m-valent hydrocarbon group having ² to 36 carbon atoms, R ² and R ⁴ each independently represents a divalent hydrocarbon group having 1 to 4 carbon atoms, R ³ represents a straight chain, branched chain, or h + 1 valent hydrocarbon group containing an aliphatic ring or an aromatic ring, which may have a urethane bond, R ⁵ represents a divalent hydrocarbon group, and R ⁶ represents Represents a hydrogen atom or a hydroxy group. m is an integer greater than or equal to 2, h is an integer greater than or equal to 1, k and n represent the repeating number of the structure in a parenthesis, and are each independently an integer of the range of 0-1000, both k and n Will never be zero.

  As is clear from the general formula (1), the specific compound (1) has a urethane structure and a hydrophilic hydrocarbon oxy group in the main chain, and has a hydrophobic hydrocarbon group at the terminal, and is modified to be hydrophobic. Urethane copolymer.

In the general formula (1), R ¹ represents an m-valent hydrocarbon group having 2 to 36 carbon atoms, preferably a divalent to octavalent hydrocarbon group. The hydrocarbon group represented by R ¹ may contain an oxygen atom between carbon atoms.

In the general formula (1), R ² and R ⁴ each independently represent a divalent hydrocarbon group having 1 to 4 carbon atoms, preferably an alkylene group having 2 to 4 carbon atoms.

In the general formula (1), R ³ represents a linear, branched, or h + 1 valent hydrocarbon group containing an aliphatic ring or an aromatic ring, which may have a urethane bond, preferably divalent to 4 A divalent hydrocarbon group, more preferably a divalent hydrocarbon group. The number of carbon atoms in the hydrocarbon group represented by R ^3, 1-10 are preferred.

In the general formula (1), R ⁵ represents a divalent hydrocarbon group. The hydrocarbon groups represented by R ⁵ is preferably 8 to 36, 12 to 24 is more preferable. Examples of the divalent hydrocarbon group represented by R ⁵ include divalent groups obtained by removing one hydrogen atom from an alkyl group, alkenyl group, alkylaryl group, cycloalkyl group, cycloalkenyl group, and the like. . Among these, the divalent hydrocarbon group represented by R ⁵ is preferably an alkylene group obtained by removing one hydrogen atom from an alkyl group.

In the general formula (1), R ⁶ represents a hydrogen atom or a hydroxy group.
When R ⁶ is a hydrogen atom, R ⁶ becomes a terminal group together with the divalent hydrocarbon group represented by R ⁵ .

In the general formula (1), m is the same as the valence of the hydrocarbon group represented by R ¹ and is an integer of 2 or more.
In the general formula (1), h is the valence -1 of the hydrocarbon group represented by R ^3, is an integer of 1 or more. h is preferably 1 to 3, and more preferably 1.

In the general formula (1), k is the number of repetitions (polymerization degree) of the (O—R ² ) structure and may be an integer in the range of 0 to 1000.
In the general formula (1), n is the number of repetitions of the (R ⁴ —O) structure (degree of polymerization) and may be an integer in the range of 0 to 1000.
In general formula (1), both k and n are not 0.

<Compound represented by formula (1-1)>
As the compound represented by the general formula (1) in the present invention, a compound represented by the following general formula (1-1) (hereinafter referred to as “specific compound (1-1)” as appropriate) is preferable.

In general formula (1-1), R ¹¹ represents a m1-valent hydrocarbon group having 2 to 12 carbon atoms, and R ¹² and R ¹⁴ each independently represents a divalent hydrocarbon group having 1 to 4 carbon atoms. , R ¹³ represents a linear, branched, or h1 + 1 valent hydrocarbon group containing an aliphatic ring or an aromatic ring which may have a urethane bond, and R ¹⁵ represents a monovalent hydrocarbon group. m1 is an integer greater than or equal to 2, h1 is an integer greater than or equal to 1, k1 and n1 represent the repeating number of the structure in a parenthesis, and are each independently an integer of the range of 0-1000, both k1 and n1 Will never be zero.

R ¹¹ in the general formula (1-1) corresponds to R ¹ in the general formula (1).
Since R ¹¹ in the general formula (1-1) has the same meaning as R ¹ in the general formula (1) except for the number of carbon atoms, description other than the number of carbon atoms and preferred embodiments is omitted here.
The hydrocarbon group represented by R ¹¹ has 2 to 12 carbon atoms, preferably 2 to 4 carbon atoms. The hydrocarbon group represented by R ¹¹ is preferably a linear or branched aliphatic hydrocarbon group, and more preferably a linear aliphatic hydrocarbon group.

R ¹² and R ¹⁴ in the general formula (1-1) correspond to R ² and R ⁴ in the general formula (1), respectively.
R ¹² and R ¹⁴ in the general formula (1-1) have the same meanings as R ² and R ⁴ in the general formula (1), respectively, and preferable embodiments thereof are also the same, and thus description thereof is omitted here.

R ¹³ in the general formula (1-1) corresponds to R ³ in the general formula (1).
Since R ¹³ in the general formula (1-1) has the same meaning as R ³ in the general formula (1), descriptions other than the preferred embodiments are omitted here.
The hydrocarbon group represented by R ¹³ is preferably an aliphatic hydrocarbon group.

M1, h1, k1, and n1 in the general formula (1-1) correspond to m, h, k, and n in the general formula (1), respectively.
Since m1, h1, k1, and n1 in the general formula (1-1) have the same meanings as m, h, k, and n in the general formula (1), descriptions other than the preferred embodiments are omitted here. .
m1 is preferably 2, and h1 is preferably 1.
k1 is preferably an integer of 1 to 500, more preferably an integer of 100 to 300.
n1 is preferably an integer of 1 to 200, more preferably an integer of 10 to 100.

R ¹⁵ in the general formula (1-1) corresponds to a group represented by “R ⁵ -R ⁶ ” when R ⁶ in the general formula (1) is a hydrogen atom.
In the general formula (1-1), R ¹⁵ is a branched alkyl group (that is, the divalent hydrocarbon group represented by R ⁵ in the general formula (1) is a branched alkylene group, and , R ⁶ is preferably a hydrogen atom.

The specific compound (1-1) is, for example, “R ¹¹ — [(O—R ¹² ) _k1 —OH] _m1 (where R ¹¹ , R ¹² , k1, and m1 are the same as defined above”). a polyether polyol represented, _{^{"R 13 - (NCO) h1 +}} 1 ( ^{wherein, R 13} and h1 are the same as defined above)" and a polyisocyanate represented by the ^"HO- (R 14 _{-O) n1} -R ¹⁵ (wherein R ¹⁴ , R ¹⁵ , and n1 are as defined above) "is preferably obtained by a method of reacting with a polyether monoalcohol.
Each of the above-mentioned polyether polyol, polyisocyanate, and polyether monoalcohol, which are raw materials used in the reaction, may be one kind or two or more kinds.

When the specific compound (1-1) is obtained by the above method, the hydrocarbon groups represented by R ¹¹ , R ¹² , R ¹³ , R ¹⁴ , and R ¹⁵ in the general formula (1-1) are used. the three ingredients _{^{"R 11 - [(O-R}} 12) k1 -OH] m1 ", - by ^"R 13 _{(NCO) h1 + 1",} and _{^{"HO- (R 14 -O) n1 -R}} 15 ', Each is decided.
The charging ratio of the above three raw materials is not particularly limited. For example, the ratio of the isocyanate group derived from polyisocyanate to the hydroxyl group derived from polyether polyol and polyether monoalcohol is NCO: OH = 0. It is preferably in the range of 8: 1 to 1.4: 1.

The polyether polyol represented by “R ¹¹ -[(O—R ¹² ) _k1 -OH] _m1 ” is obtained by addition polymerization of alkylene oxide such as ethylene oxide, propylene oxide, butylene oxide, epichlorohydrin, etc. to m1 valent polyol. Can be obtained.
Therefore, the hydrocarbon group represented by R ¹¹ is determined by the structure of the m1 valent polyol used for the synthesis of the specific compound (1-1). Further, the hydrocarbon group represented by R ¹² is determined by alkylene oxide or the like to be addition-polymerized to the m1-valent polyol.

As the polyol, divalent to octavalent polyols are preferable. Specifically, dihydric alcohols such as ethylene glycol, propylene glycol, butylene glycol, hexamethylene glycol and neopentyl glycol; glycerin, trioxyisobutane, 1, 2 , 3-butanetriol, 1,2,3-pentatriol, 2-methyl-1,2,3-propanetriol, 2-methyl-2,3,4-butanetriol, 2-ethyl-1,2,3 -Butanetriol, 2,3,4-pentanetriol, 2,3,4-hexanetriol, 4-propyl-3,4,5-heptanetriol, 2,4-dimethyl-2,3,4-pentanetriol, Pentamethylglycerin, pentaglycerin, 1,2,4-butanetriol, 1,2,4-pen Trihydric alcohols such as Ntriol, Trimethylolethane, Trimethylolpropane; Pentaerythritol, 1,2,3,4-pentanetetrol, 2,3,4,5-hexanetetrol, 1,2,4,5 -Tetrahydric alcohols such as pentanetetrol, 1,3,4,5-hexanetetrol; pentahydric alcohols such as adnit, arabit and xylit; hexavalent alcohols such as dipentaerythritol, sorbit, mannitol and exit; Examples thereof include octahydric alcohols such as sugar.
In the present invention, the polyol is preferably a dihydric alcohol, and particularly preferably ethylene glycol.

  As the alkylene oxide or the like to be addition-polymerized to the above m1 polyol, an alkylene oxide having 2 to 4 carbon atoms is preferable, and ethylene oxide is particularly preferable from the viewpoint that it is easily available and can exhibit an excellent effect. .

The form of addition polymerization of alkylene oxide or the like may be homopolymerization or copolymerization using two or more kinds. In the case of copolymerization, the form of copolymerization may be random polymerization or block polymerization. These addition polymerization methods may be ordinary methods.
K1 which shows a polymerization degree should just be the range of 0-1000, the range of 1-500 is preferable, and the range of 100-300 is more preferable.
Ratio of ethylene groups in the total ^{R 12} is preferably in the range of 50 wt% to 100 wt% of the total ^{R 12.}

The molecular weight of “R ¹¹ — [(O—R ¹² ) _k1 —OH] _m1 ” is preferably 500 to 100,000, and particularly preferably 1,000 to 50,000.

Polyisocyanates represented by ^- "R ¹³ (NCO) h1 + _1" as long as they have two or more isocyanate groups in the molecule is not particularly limited.
Therefore, the hydrocarbon group represented by R ¹³ is determined by the polyisocyanate used for the synthesis of the specific compound (1-1).
Examples of the polyisocyanate used in the present invention include aliphatic diisocyanate, aromatic diisocyanate, alicyclic diisocyanate, biphenyl diisocyanate, phenylmethane diisocyanate, triisocyanate, and tetraisocyanate. Among these, aliphatic diisocyanates are preferable as the polyisocyanate used in the present invention.

  Examples of the aliphatic diisocyanate include methylene diisocyanate, dimethylene diisocyanate, trimethylene diisocyanate, tetramethylene diisocyanate, pentamethylene diisocyanate, hexamethylene diisocyanate, 2,2-dimethylpentane diisocyanate, 3-methoxyhexane diisocyanate, octamethylene diisocyanate, 2 2,4-trimethylpentane diisocyanate, nonamethylene diisocyanate, decamethylene diisocyanate, metaxylylene diisocyanate, paraxylylene diisocyanate, tetramethylxylylene diisocyanate and the like. Among these, hexamethylene diisocyanate is preferable as the aliphatic diisocyanate used in the present invention.

  Examples of the aromatic diisocyanate include metaphenylene diisocyanate, paraphenylene diisocyanate, 2,4-tolylene diisocyanate, 2,6-tolylene diisocyanate, dimethylbenzene diisocyanate, ethylbenzene diisocyanate, isopropylbenzene diisocyanate, tolidine diisocyanate, 1,4- Examples include naphthalene diisocyanate, 1,5-naphthalene diisocyanate, 2,6-naphthalene diisocyanate, and 2,7-naphthalene diisocyanate.

  Examples of the alicyclic diisocyanate include hydrogenated xylylene diisocyanate and isophorone diisocyanate.

  Examples of the biphenyl diisocyanate include biphenyl diisocyanate, 3,3′-dimethylbiphenyl diisocyanate, and 3,3′-dimethoxybiphenyl diisocyanate.

  Examples of the diisocyanate of phenylmethane include diphenylmethane-4,4′-diisocyanate, 2,2′-dimethyldiphenylmethane-4,4′-diisocyanate, diphenyldimethylmethane-4,4′-diisocyanate, 2,5,2 ′. , 5′-tetramethyldiphenylmethane-4,4′-diisocyanate, cyclohexylbis (4-isothiontphenyl) methane, 3,3′-dimethoxydiphenylmethane-4,4′-diisocyanate, 4,4′-dimethoxydiphenylmethane 3,3′-diisocyanate, 4,4′-diethoxydiphenylmethane-3,3′-diisocyanate, 2,2′-dimethyl-5,5′-dimethoxydiphenylmethane-4,4′-diisocyanate, 3,3′- Dichlorodiphenyldimethyl Tan-4,4'-diisocyanate, benzophenone-3,3'-diisocyanate, and the like.

  Examples of the triisocyanate of phenylmethane include 1-methylbenzene-2,4,6-triisocyanate, 1,3,5-trimethylbenzene-2,4,6-triisocyanate, and 1,3,7-naphthalenetriisocyanate. Isocyanate, biphenyl-2,4,4′-triisocyanate, diphenylmethane-2,4,4′-triisocyanate, 3-methyldiphenylmethane-4,6,4′-triisocyanate, triphenylmethane-4,4 ′, 4 ″ -triisocyanate, 1,6,11-undecane triisocyanate, 1,8-diisocyanate-4-isocyanate methyloctane, 1,3,6-hexamethylene triisocyanate, bicycloheptane triisocyanate, tris (isocyanate phenyl) Such as thiophosphate It is below.

  As the polyisocyanate, dimer or trimer (isocyanurate bond) of the above polyisocyanate may be used. Moreover, you may use the biuret which made said polyisocyanate and amine react.

Furthermore, you may use the polyisocyanate which has the urethane bond which made these polyisocyanate and polyol react. As the polyol used here, divalent to octavalent polyols are preferable, and the aforementioned polyols are preferable.
Note that - as ^"R 13 _{(NCO) h1 + 1",} the case of using trivalent or more polyisocyanates, polyisocyanate, polyisocyanate having the above urethane bond.

The polyether monoalcohol represented by “HO— (R ¹⁴ —O) _n1 —R ¹⁵ ” is not particularly limited as long as it is a monohydric alcohol polyether.
The polyether monoalcohol represented by “HO— (R ¹⁴ —O) _n1 -R ¹⁵ ” is obtained by subjecting monovalent alcohol to addition polymerization of alkylene oxide such as ethylene oxide, propylene oxide, butylene oxide, epichlorohydrin, and the like. Can be obtained.
Therefore, the hydrocarbon group represented by R ¹⁴ is determined by alkylene oxide or the like that undergoes addition polymerization to a monovalent alcohol. The hydrocarbon group represented by R ¹⁵ is determined by a monovalent alcohol used for the synthesis of the specific compound (1-1).

The monovalent alcohol here is an alcohol represented by the following general formula (2), (3), or (4). Therefore, R ¹⁵ corresponds to a group excluding the hydroxyl group in the following general formulas (2) to (4).

Formula ^(2): R a -OH
Formula ^{(3): R b -CH (} R c) -R d -OH
General formula (4): R < ^e > -CH (R < ^f >)-OH

In the general formulas (2) to (4), R ^a , R ^b , R ^c , R ^e , and R ^f each independently represent a hydrocarbon group, specifically, an alkyl group, an alkenyl group, an alkyl group Examples thereof include hydrocarbon groups such as an aryl group, a cycloalkyl group, and a cycloalkenyl group.

  Examples of the alkyl group include methyl, ethyl, propyl, isopropyl, butyl, isobutyl, tertiary butyl, pentyl, isopentyl, neopentyl, tertiary pentyl, hexyl, heptyl, octyl, 2-ethylhexyl, nonyl, decyl, undecyl, dodecyl. , Tridecyl, isotridecyl, myristyl, palmityl, stearyl, isostearyl, icosyl, docosyl, tetracosyl, triacontyl, 2-octyldodecyl, 2-dodecylhexadecyl, 2-tetradecyloctadecyl, monomethyl branched-isostearyl and the like.

  Examples of the alkenyl group include vinyl, allyl, propenyl, isopropenyl, butenyl, pentenyl, isopentenyl, hexenyl, heptenyl, octenyl, nonenyl, decenyl, undecenyl, dodecenyl, tetradecenyl, oleyl and the like.

  Examples of the alkylaryl group include toluyl, xylyl, cumenyl, mesityl, ethylphenyl, propylphenyl, butylphenyl, pentylphenyl, hexylphenyl, heptylphenyl, octylphenyl, nonylphenyl and the like.

Examples of the cycloalkyl group include cyclopentyl, cyclohexyl, cycloheptyl, methylcyclopentyl, methylcyclohexyl, methylcycloheptyl, and the like.
Examples of the cycloalkenyl group include cyclopentenyl, cyclohexenyl, cycloheptenyl, methylcyclopentenyl, methylcyclohexenyl, methylcycloheptenyl, and the like.

In the general formula (3), R ^d represents a divalent hydrocarbon group. Examples of the divalent hydrocarbon group represented by R ^d include a divalent group obtained by removing one hydrogen atom from an alkyl group, an alkenyl group, an alkylaryl group, a cycloalkyl group, a cycloalkenyl group, and the like. Can be mentioned. Specifically, examples of the divalent hydrocarbon group represented by R ^d include an alkylene group, an alkenylene group, an alkylarylene group, a cycloalkylene group, and a cycloalkenylene group.

  As the alkylene oxide or the like to be addition-polymerized to the above monohydric alcohol, an alkylene oxide having 2 to 4 carbon atoms is preferable, and ethylene oxide is particularly preferable from the viewpoint of being easily available and capable of exhibiting an excellent effect. .

The form of addition polymerization of alkylene oxide or the like may be homopolymerization or copolymerization using two or more kinds. In the case of copolymerization, the form of copolymerization may be random polymerization or block polymerization. These addition polymerization methods may be ordinary methods.
N1 which shows a polymerization degree should just be the range of 0-1000, the range of 1-200 is preferable, and the range of 10-200 is more preferable.
Ratio of ethylene groups in the total ^{R 14} is preferably in the range of 50 wt% to 100 wt% of the total ^{R 14,} and more preferably in the range of 65 wt% to 100 wt%.

  As a method for producing the specific compound (1-1), for example, the polyether and the isocyanate are heated at 80 to 90 ° C. for 1 to 3 hours in the same manner as in the reaction of the usual polyether and isocyanate, It can be obtained by reacting.

A polyether polyol represented by ^- _{'[(O-R 12) k1} -OH] m1 R 11 "(a), - the" ^R 13 _{(NCO) h1 + 1} "represented by a polyisocyanate (b)," When the polyether monoalcohol (c) represented by “HO— (R ¹⁴ —O) _n1 —R ¹⁵ ” is reacted, other than the compound (copolymer) represented by the general formula (1-1) Ingredients may be by-produced.
For example, when a diisocyanate is used, the main product is a c-b-a-b-c type copolymer represented by the general formula (1-1). , Cb- (ab) _x -abc type copolymers may be by-produced.
In this case, the aqueous gel cosmetic composition of the present invention can be used in the state of a mixture containing the copolymer without separating the copolymer of the cbbabcc type represented by the general formula (1-1). May be used.

As the specific compound (1-1) used in the present invention, compounds described in JP-A-9-71766 are suitable.
As the specific compound (1-1) used in the present invention, PEG-240 / decyltetradeceth-20 / hexamethylene diisocyanate (HDI) copolymer is particularly suitable.
Such a copolymer is commercially available from ADEKA under the trade name “Adecanol GT-700”.

<Compound represented by formula (1-2)>
The compound represented by the general formula (1) in the present invention is preferably a compound represented by the following general formula (1-2) (hereinafter referred to as “specific compound (1-2)” as appropriate).

In the general formula (1-2), R ²¹ represents a m2-valent saturated hydrocarbon group having 6 to 36 carbon atoms, and R ²² represents a methyldiphenylene group, a hexamethylene group, a methyldicyclohexylene group, 3-methyl. −3,5,5-trimethylcyclohexylene group, dimethylphenylene group, or tolylene group, and R ²³ represents a hydrogen atom or a methyl group. n2 represents an integer of 90 to 900, and m2 represents an integer of 1 to 5.

In the general formula (1-2), R ²¹ is a saturated hydrocarbon group having 6 to 36 carbon atoms, preferably a linear alkyl group or branched alkyl group having 6 to 36 carbon atoms.

The specific compound (1-2) includes a polyalkylene oxide compound represented by “H— (O—CHR ²³ CH ₂ ) _n2 —OH (wherein R ²³ and n2 are as defined above)”, “ A monovalent hydrophobic alcohol represented by “HO—R ²¹ (wherein R ²¹ is as defined above)”, and “R ²² <(NCO) ₂ (wherein R ²² is as defined above). It can be obtained by reacting these raw materials with a diisocyanate compound represented by “)” as a raw material.

Specific examples of the polyalkylene oxide compound represented by “H— (O—CHR ²³ CH ₂ ) _n2 —OH” include polyethylene oxide, polypropylene oxide, polyethylene oxide / polypropylene oxide (preferably ethylene oxide and propylene). A copolymer with an oxide) and the like.
Among these, the polyalkylene oxide compound represented by “H— (O—CHR ²³ CH ₂ ) _n2 —OH” is preferably a polyalkylene oxide compound containing 70% by mass or more of an ethylene oxide group, and more preferably. Is a polyalkylene oxide compound having 95% by mass or more of ethylene oxide groups.

The monovalent hydrophobic alcohol represented by “HO—R ²¹ ” is preferably an alcohol having a solubility in water of 0.4% by mass or less, and specifically includes hexyl alcohol, heptyl alcohol, octyl alcohol. , Nonyl alcohol, decyl alcohol, undecyl alcohol, dodecyl alcohol, tridecyl alcohol, tetradecyl alcohol, pentadecyl alcohol, cetyl alcohol, heptadecyl alcohol, octadecyl alcohol, nonadecyl alcohol, aralkyl alcohol, 2-octyldodecanol and Examples include behenyl alcohol, and preferably monovalent hydrophobic alcohol selected from the group consisting of cetyl alcohol and behenyl alcohol.
These monovalent hydrophobic alcohols may be used alone or in combination of two or more.

  The monovalent hydrophobic alcohol is preferably used in a proportion of 0.2 mol to 1.0 mol, and used in a proportion of 0.25 mol to 0.70 mol, relative to 1 mol of the polyalkylene oxide compound. It is more preferable.

Specific examples of the diisocyanate compound represented by “R ²² <(NCO) ₂ ” include 4,4′-diphenylmethane diisocyanate (MDI), 1,6-hexamethylene diisocyanate (HDI), dicyclohexylmethane-4, 4′-diisocyanate (HMDI), 3-isocyanate methyl-3,5,5-trimethylcyclohexyl isocyanate (IPDI), 1,8-dimethylbenzole-2,4-diisocyanate, 2,4-tolylene diisocyanate (TDI), etc. Is mentioned.
Among these, the diisocyanate compound represented by “R ²² <(NCO) ₂ ” is selected from the group consisting of dicyclohexylmethane-4,4′-diisocyanate (HMDI) and 1,6-hexamethylene diisocyanate (HDI). Preferred is a diisocyanate compound.
These diisocyanate compounds may be used alone or in combination of two or more.

  The diisocyanate compound is composed of a polyisocyanate compound and a monovalent hydrophobic alcohol compound, and the number of moles of an isocyanate group ([− NCO] is preferably used at a ratio of 0.67 mol to 0.91 mol, and more preferably at a ratio of 0.70 mol to 0.90 mol.

Examples of a method of reacting a polyalkylene oxide compound, a monovalent hydrophobic alcohol, and a diisocyanate compound include, for example, a method of reacting by dissolving or dispersing in a reaction solvent such as toluene, xylene, dimethylformamide, and pulverizing a solid into a powder Alternatively, there may be mentioned a method in which the mixture is melted in a liquid state and both are uniformly mixed, and then heated to a predetermined temperature for reaction.
As a method for synthesizing the specific compound (1-2), the method described in paragraphs [0049] to [0051] of JP2013-116941A is preferably used.

  As the specific compound (1-2) in the present invention, bisstearyl PEG / PPG-8 / 6 (methylenediphenyl diisocyanate / PEG-400) copolymer, that is, Sumitomo Seika Co., Ltd. under the trade name "Apeck HU type C" More commercially available compounds are preferred.

Content of the specific compound (1) in the aqueous gel cosmetics of this invention is 0.5 mass%-5 mass% with respect to the total mass of aqueous gel cosmetics, and 1 mass%-3 mass. %, Preferably 1.3% by mass to 2% by mass.
When the content of the specific compound (1) with respect to the total amount of the gel cosmetic of the present invention is within the above range, an appropriate hardness as an aqueous gel cosmetic can be obtained. Moreover, the gel cosmetics which are excellent in usability, such as ease of scooping with a spatula and ease of extension to the skin during application, can be obtained.

[Astaxanthin]
The gel cosmetic of the present invention contains astaxanthin in an amount of 1 ppm to 100 ppm in terms of mass with respect to the total amount of the gel cosmetic.
Astaxanthin is a kind of carotenoid, and examples thereof include astaxanthin derived from plants, algae, bacteria, and the like.
Astaxanthin in the present invention is not limited to astaxanthin derived from natural products, and any astaxanthin may be used as long as it is obtained according to a conventional method.

Astaxanthin has good antioxidant effect, whitening effect and the like.
Astaxanthin may be crystalline astaxanthin. Here, "crystalline astaxanthin" is not a word indicating a specific astaxanthin, but when it is in the form of oil, paste, etc. containing astaxanthin, due to various factors such as its production method, treatment method, storage method, It means astaxanthin which can exist as a crystal at any temperature in the temperature range of −5 ° C. to 35 ° C. Astaxanthin is known as a carotenoid in which crystals are easily present.

  Astaxanthin in the present invention includes at least one selected from astaxanthin and derivatives thereof (for example, esters of astaxanthin). In the present invention, astaxanthin and its derivatives are collectively referred to as “astaxanthin”.

As astaxanthin, in addition to astaxanthin derived from natural products such as plants, algae, crustaceans, and bacteria, a synthetic product of astaxanthin obtained according to a conventional method can also be used.
Astaxanthin can be extracted from cultures such as red yeast Phaffia, green algae Hematococcus, marine bacteria, krill, Adonis (Fukujukusa), and the like.
From the viewpoint of quality and productivity, astaxanthin is particularly preferably astaxanthin derived from an extract from Haematococcus algae (hereinafter referred to as “Hematococcus alga extract”) or an extract from krill.

  Specific examples of Haematococcus algae include Haematococcus pluviaris, Haematococcus lacustris, Haematococcus genus, Haematococcus capecus, Examples thereof include Haematococcus zimbabwiens.

The hematococcus algae extract is obtained by crushing the above-mentioned hematococcus algae as necessary, for example, by the method disclosed in JP-A-5-68585, etc. to obtain acetone, ether, chloroform, alcohol (for example, , Ethanol, methanol, etc.) or an extraction solvent such as supercritical carbon dioxide can be added.
Examples of commercially available products of Haematococcus algae extract include ASTOTS-S, ASTOTS-2.5 O, ASTOTS-5 O, ASTOTS-10 O from Takeda Paper Co., Ltd., Asteryl from Fuji Chemical Industry Co., Ltd. Examples include Oil 50F, Asteryl Oil 5F, and BioAsin SCE7 manufactured by Toyo Enzyme Chemical Co., Ltd.

The content of astaxanthin in the Haematococcus alga extract as a pure pigment content is preferably 0.001% by mass to 50% by mass, more preferably 0.01% by mass to 25%, from the viewpoint of handling during production. % By mass.
In addition, the Haematococcus alga extract may contain astaxanthin or its ester as a pigment | dye pure part similarly to the pigment | dye described in Unexamined-Japanese-Patent No. 2-49091. A Haematococcus alga extract containing an ester of astaxanthin is generally preferably used in an amount of 50 mol% or more, preferably 75 mol% or more, more preferably 90 mol% or more.

The gel cosmetic of the present invention may contain astaxanthin prepared using an astaxanthin-containing oil or paste. From the viewpoint of improving the stability of astaxanthin in the gel cosmetic composition of the present invention, it is preferable to contain astaxanthin in the form of a dispersion.
The dispersion containing astaxanthin may be an oil-in-water dispersion (O / W dispersion) or a water-in-oil dispersion (W / O dispersion). The dispersion containing astaxanthin is more preferably an oil-in-water dispersion containing astaxanthin as one of the oil phase components.
A dispersion containing astaxanthin can be prepared by a conventional method.
As described above, the content of astaxanthin relative to the total amount of the gel cosmetic of the present invention is 1 ppm to 100 ppm in terms of mass, preferably 10 ppm to 100 ppm, more preferably 10 ppm to 50 ppm, more preferably 10 ppm. More preferably, it is -30 ppm.
If the content is less than 1 ppm, it may be difficult to obtain the expected effect by containing astaxanthin. On the other hand, when the content exceeds 100 ppm, it may be difficult to maintain the stability of astaxanthin in the gel cosmetic when stored for a long period of time, and specifically, aggregation of astaxanthin occurs. There is.

[Contents of Na and K with respect to the total amount of the gel cosmetic]
The gel cosmetic of the present invention contains astaxanthin, TMG and the specific compound (1) at the contents specified in the present invention, and the total content of elements selected from Na and K with respect to the total amount of the aqueous gel cosmetic is 0. 0.05% by mass or more.

Various cosmetic ions are contained in the gel cosmetic. Of these, monovalent ions are preferred as the cation ions, and in particular, monovalent cations such as Na cation and K cation can dissolve, emulsify or disperse various anionic compounds stably in gel cosmetics. Useful to make. By containing Na cation, K cation, etc., the gel stability and gel strength of the gel cosmetic tend to be further improved.
From the viewpoint of stabilization of the gel cosmetic, monovalent cations such as Na cation and K cation are particularly preferable. With divalent or higher cation such as Ca cation and Mg cation, the stabilizing effect of the gel cosmetic is Since it is small, it is not preferable.

The total content of elements selected from Na and K with respect to the total amount of the gel cosmetic is preferably 0.05% by mass to 1% by mass, more preferably 0.05% by mass to 0.5% by mass. Preferably, it is 0.07 mass%-0.2 mass%.
If the total content of elements selected from Na and K is less than 0.05% by mass, the stabilizing effect of the gel cosmetic may be insufficient. This is presumably because if the total content of elements selected from Na and K is too small, the effect of separating the anionic compound contained in the gel cosmetic cannot be sufficiently obtained.
Although there is no restriction | limiting in particular in the upper limit of the total content of the element chosen from Na and K, Even if it mixes exceeding 1 mass%, a stabilization effect will not improve more, From such a viewpoint, The content is preferably about 1% by mass or less. When a large amount of an element selected from Na and K exceeds 1% by mass, excessive Na ions and K ions may reduce the stabilizing effect of the gel cosmetic.

It is difficult to directly measure the content of Na cation or K cation contained in gel cosmetics, but by measuring the total content of elements selected from Na and K contained in the total amount of gel cosmetics The total content of Na cations and K cations that contribute to the stabilization of gel cosmetics can be estimated.
That is, when the total content of elements selected from Na and K contained in the total amount of the gel cosmetic is 0.05% by mass or more, an amount of Na cation that contributes to the stabilization of the gel in the gel cosmetic and It can be estimated that a cation selected from K cations is contained.
The total content of elements selected from Na and K with respect to the total amount of the gel cosmetic can be measured by a known method such as high frequency inductively coupled plasma (ICP) emission spectroscopy or ion chromatography.

The total content of elements selected from Na and K in the gel cosmetic of the present invention can be adjusted by the type and content of components used in the gel cosmetic.
The element selected from Na and K may be derived from, for example, a salt compound containing an element selected from Na and K that can be used in cosmetics.

[Other ingredients]
In addition to the elements selected from astaxanthin, TMG, specific compound (1) and Na and K, the aqueous gel cosmetic of the present invention contains other components other than these components within the range not impairing the effects of the present invention. It may be contained if desired.
Hereinafter, other components that can be used in the aqueous gel cosmetic of the present invention will be described.

(water)
The aqueous gel cosmetic of the present invention contains water.
The water is not particularly limited as long as it can be used for cosmetics, and tap water, natural water, purified water, distilled water, ion exchange water, pure water, ultrapure water such as milli-Q water, etc. Can also be used. Note that Milli-Q water is ultrapure water obtained by a Milli-Q water production apparatus, which is an ultrapure water production apparatus manufactured by Merck Millipore.
Of these, purified water, distilled water, ion-exchanged water, pure water, milli-Q water, and the like are preferable from the viewpoint of few impurities.
The water content in the present invention is preferably 50% by mass to 95% by mass, more preferably 60% by mass to 90% by mass, and 70% by mass with respect to the total mass of the aqueous gel cosmetic. More preferably, it is -88 mass%.

(Water-soluble liquid component)
The gel cosmetic of the present invention can contain a water-soluble liquid component, that is, a liquid component in which the amount of the target substance dissolved in water at 25 ° C. exceeds 1% by mass.
There is no restriction | limiting in particular in a water-soluble liquid component, If it is a component which can generally be included in cosmetics, it can be used according to the objective.
Examples of water-soluble liquid components that can be used in the present invention include monohydric alcohols such as ethanol and isopropanol; dihydric alcohols such as ethylene glycol, propylene glycol, butylene glycol, diethylene glycol, and dipropylene glycol; glycerin, 1, Examples include trihydric alcohols such as 2,3-butanetriol, trimethylolethane, and trimethylolpropane.

(Gel stabilizer)
The gel cosmetic of the present invention can contain a gel stabilizer.
As the gel stabilizer, a compound having a long-chain hydrocarbon group and a hydrophilic group is preferable.
The carbon chain of the long-chain hydrocarbon group may be a straight chain or branched chain, and may be a saturated or unsaturated carbon chain. The carbon number of the long chain hydrocarbon group is preferably 12-22.
The hydrophilic group is preferably a hydrophilic group selected from the group consisting of a carboxylic acid group, a phosphoric acid group, and a sodium salt or a potassium salt thereof.

Examples of gel stabilizers that can be used in the present invention include trisodium ascorbyl palmitate (hereinafter referred to as APPS as appropriate), sodium tocopheryl phosphate, sodium isostearate, potassium isostearate, sodium oleate, Examples include potassium oleate. The gel cosmetic of the present invention preferably contains at least one compound selected from the group consisting of APPS, sodium tocopheryl phosphate, sodium isostearate, potassium isostearate, sodium oleate, and potassium oleate.
By containing these compounds, the temporal stability of the gel hardness of the gel cosmetic is further improved.
Among these, APPS, sodium tocopheryl phosphate, sodium isostearate, or sodium oleate are preferable from the viewpoint of stabilizing the gel hardness and the solubility of the gel stabilizer. From the viewpoint, APPS is particularly preferable.
APPS is also available as a commercial product, for example, trisodium ascorbyl phosphate palmitate manufactured by Showa Denko K.K.

  The element selected from Na and K described above includes elements derived from trisodium ascorbyl palmitate, sodium tocopheryl phosphate, sodium isostearate, potassium isostearate, sodium oleate, and potassium oleate. .

Only one compound selected from trisodium ascorbyl palmitate, sodium tocopheryl phosphate, sodium isostearate, potassium isostearate, sodium oleate, and potassium oleate is used in the gel cosmetic of the present invention. Or two or more of them may be used in combination.
The total content of these compounds with respect to the total amount of the gel cosmetic of the present invention is preferably 0.01% by mass to 5% by mass, more preferably 0.05% by mass to 1% by mass. More preferably, the content is 1% by mass to 0.7% by mass, and particularly preferably 0.2% by mass to 0.5% by mass.

(Buffering agent)
The gel cosmetic of the present invention may contain a buffer from the viewpoint of further stabilizing the pH. When the gel cosmetic contains a buffer and the pH of the gel cosmetic is stabilized, physical properties such as gel hardness of the gel cosmetic become more stable.
As the buffer, at least one compound selected from the group consisting of citric acid, phosphoric acid, citrate and phosphate is preferable, and phosphoric acid is more preferable.
A buffer may contain only 1 type and may use 2 or more types together according to the objective.
The pH of the gel cosmetic is preferably 7-8, and phosphoric acid is more preferable because the buffering performance is high in the pH 7-8 region.

The content when citric acid is contained as a buffering agent is preferably 0.01% by mass to 1% by mass and more preferably 0.05% by mass to 0.5% by mass with respect to the total amount of the gel cosmetic. It is more preferable that it is 0.05 mass%-0.2 mass%.
When the content of citric acid is within the above range, the change in pH of the gel cosmetic is suppressed, and the astaxanthin aggregation suppression effect becomes better.

The content when phosphoric acid is contained as a buffering agent is preferably 0.01% by mass to 1% by mass, more preferably 0.05% by mass to 0.6% by mass with respect to the total amount of the gel cosmetic. More preferably, the content is 0.1% by mass to 0.2% by mass.
When the content of phosphoric acid is in the above range, the change in pH of the gel cosmetic is suppressed, and the astaxanthin aggregation suppression effect becomes better.

The aqueous gel cosmetic of the present invention may contain various components usually used in cosmetics in addition to the other preferable components described above.
Hereinafter, other components that can be used in the aqueous gel cosmetic of the present invention will be described.

<Polyhydric alcohol>
The aqueous gel cosmetic of the present invention can contain a polyhydric alcohol. When the aqueous gel cosmetic of the present invention contains a polyhydric alcohol, the moisturizing property is improved and a good feeling of use may be obtained.
Examples of the polyhydric alcohol include glycerin, ethylhexylglycerin, 1,3-butylene glycol, ethylene glycol; polysaccharides such as reduced starch syrup, sucrose, erythritol, xylitol, glucose, galactose, sorbitol, maltotriose, and trehalose. Can be mentioned.
The aqueous gel cosmetic of the present invention may contain a polyhydric alcohol as described above alone or in combination of two or more.

  When the aqueous gel cosmetic of the present invention contains a polyhydric alcohol, the content is not particularly limited. The content of the polyhydric alcohol in the aqueous gel cosmetic of the present invention is preferably 1% by mass to 50% by mass with respect to the total mass of the aqueous gel cosmetic, and 2% by mass to 20% by mass. It is more preferable that it is 5 mass%-10 mass%.

<Other additive components>
The aqueous gel cosmetic of the present invention may contain an additive component usually used in the cosmetic field within a range not impairing the effects of the present invention.
Examples of the additive component include functional components that exhibit useful beauty effects (for example, a moisturizing effect, a whitening effect, a skin conditioning effect, etc.) when used in cosmetics. Examples of such functional components include carotenoids other than astaxanthin such as β-carotene, zeaxanthin, lycopene, and lutein; vitamin E such as tocopherol and tocotrienol; ubiquinone such as coenzyme Q10; polysaccharide such as hyaluronic acid; glucosylceramide, galactosyl Examples thereof include glycosphingolipids such as ceramide; collagens such as hydrolyzed collagen and water-soluble collagen; amino acids such as acetylhydroxyproline, hydrolyzed white vanillain protein, and ascorbyl phosphate 3Na.
Other additive components include, for example, preservatives such as phenoxyethanol, antioxidants, colorants, thickeners, pH adjusters such as aqueous sodium hydroxide and hydrochloric acid, fragrances, antibacterial agents, ultraviolet absorbers, and active oxygen removal. Agents, antimicrobial agents, anti-inflammatory agents, minerals and the like.

[Transparency of aqueous gel cosmetics]
The aqueous gel cosmetic of the present invention preferably has a transparent appearance, and more specifically, the absorbance at a wavelength of 625 nm which is an absorption wavelength of astaxanthin is preferably 0.04 or less. The absorbance is more preferably 0.035 or less, and further preferably 0.03 or less.
The lower limit of the absorbance at a wavelength of 625 nm of the aqueous gel cosmetic is not particularly limited, but may generally be 0.001 or more.
In the aqueous gel cosmetic of the present invention, the gel cosmetic contains a specific amount of astaxanthin and the specific compound (1), respectively, and the total content of elements selected from Na and K is 0.05% by mass or more. By containing trimethylglycine, even when astaxanthin is preferably contained as dispersed particles, aggregation of the astaxanthin-containing dispersed particles over time is suppressed, so local uneven distribution of astaxanthin is suppressed and absorbance at a wavelength of 625 nm is suppressed. Can maintain good transparency of 0.04 or less over a long period of time.

  In the present invention, “having good transparency and maintaining the transparency for a long time” means that the function, shape, etc. expected of the cosmetics are maintained regardless of the time period. When stored at room temperature (25 ° C.), the absorbance at a wavelength of 625 nm is maintained at 0.04 or less.

The absorbance at a wavelength of 625 nm of the aqueous gel cosmetic of the present invention can be measured according to a usual absorbance measurement method. In the present invention, for example, when it is preferable to perform defoaming treatment, the following method can be adopted as a method for measuring absorbance.
For example, the aqueous gel cosmetic of the present invention is placed in a polystyrene (PS) disposable cell having an optical path length of 0.4 cm, and each cell is a small cooling centrifuge (model: CF5RX, Hitachi Koki Co., Ltd., swing rotor: Using T4SS31), the mixture is centrifuged at 4000 rpm for 2 minutes and defoamed. About the aqueous | water-based gel cosmetics after a defoaming process, the light absorbency with respect to the light of wavelength 625nm can be measured using a spectrophotometer (model | form: U-3310, Hitachi, Ltd.).

[Method for producing aqueous gel cosmetic]
The method for producing the aqueous gel cosmetic of the present invention is not particularly limited.
The aqueous gel cosmetic of the present invention is known by using a specific amount of the specific compound (1), a specific amount of astaxanthin, a specific amount of trimethylglycine, water and, if necessary, other components. It can be obtained according to the method for producing an aqueous gel cosmetic. In preparation, the total content of elements selected from Na and K with respect to the total amount of the gel cosmetic can be adjusted to 0.05% by mass or more by adjusting the content including other components.
One of the preferred methods for producing the aqueous gel cosmetic of the present invention is to prepare an oil phase component together with an oily component such as a medium chain fatty acid using a specific amount of astaxanthin if desired, and to a dispersion medium containing water, If necessary, the oil phase component prepared using a dispersant is dispersed to prepare a dispersion containing astaxanthin in the oil phase in advance, and the obtained astaxanthin-containing dispersion and a specific amount of the specific compound (1) And a production method including mixing a mixture of a specific amount of trimethylglycine and water and, if necessary, other components such as APPS used together under heating.

The astaxanthin-containing dispersion can be obtained by a preparation method including mixing a dispersed phase component containing at least astaxanthin and a continuous phase component.
The mixing method of the continuous phase component (water phase component) and the dispersed phase component (oil phase component) is not particularly limited, and is an ultrasonic dispersion method, a high-pressure emulsification method, or jet injection that directly injects the dispersed phase component into the continuous phase component. Known mixing methods such as the method can be used.

One preferred method for preparing the astaxanthin-containing dispersion is a pre-dispersion solution containing a specific amount of astaxanthin, other oily components used in combination as required, and a surfactant used in combination as necessary. To obtain a coarse dispersion (hereinafter referred to as “preliminary dispersion treatment step” as appropriate), and mixing the coarse dispersion with water and the like. And a dispersion method using an ultrasonic dispersion method or a high-pressure emulsification method (hereinafter, referred to as “the present dispersion treatment step” as appropriate).
Hereinafter, the preparation method of this aspect is demonstrated.

  In the preparation of the coarse dispersion in the preliminary dispersion treatment step, a liquid (pre-dispersion liquid) containing a specific amount of astaxanthin, other oily components used in combination as desired, and a surfactant is heated to 100 ° C. or higher. By carrying out the dispersion treatment in such a state, it is possible to obtain a coarse dispersion liquid in which dispersed particles (dispersed phase) containing astaxanthin that has been heated and melted are coarsely dispersed in the continuous phase.

  The dispersion pretreatment liquid may contain other components other than astaxanthin, if necessary. Examples of other components include components such as polyhydric alcohols.

In the preparation of the coarse dispersion, the pre-dispersion solution is heated to 100 ° C. or higher from the viewpoint of melting astaxanthin. The temperature of 100 ° C. or higher should be achieved when the pre-dispersion solution is subjected to a dispersion treatment. The dispersion pretreatment liquid may be heated to 100 ° C. or higher in advance and the dispersion temperature may be maintained at 100 ° C. or higher, or the dispersion pretreatment liquid may be dispersed while heating to 100 ° C. or higher. Good.
The means for heating the pre-dispersion solution to 100 ° C. or higher is not particularly limited, and a general heating device can be used. As a heating apparatus, a constant temperature chamber etc. are mentioned, for example.

  The means for dispersing the pre-dispersion solution to obtain a coarse dispersion is not particularly limited, and a general stirring device can be used. Examples of the stirrer include a magnetic stirrer, a home mixer, a paddle mixer, an impeller mixer, a homomixer, a disper mixer, and an ultra mixer.

  The time for the dispersion treatment is not particularly limited, and can be appropriately set according to the type of the stirring device, the composition of the pre-dispersion solution, and the like.

  In this dispersion treatment step, the coarse dispersion obtained in the preliminary dispersion treatment is mixed with water, and then dispersed using an ultrasonic dispersion method (hereinafter referred to as “ultrasonic dispersion treatment” as appropriate) or. A dispersion treatment using a high-pressure emulsification method (hereinafter referred to as “high-pressure emulsification treatment” as appropriate) can be performed.

  In this dispersion treatment step, an astaxanthin-containing dispersion can be obtained by mixing a coarse dispersion containing molten astaxanthin with water and the like and subjecting it to a dispersion treatment.

From the viewpoint of preventing bumping, the temperature of the coarse dispersion when mixing with water or the like is preferably set to 100 ° C. or less, and more preferably set to 90 ° C. to 100 ° C.
Although temperature, such as water, is not specifically limited, It is preferable to set to 50 to 90 degreeC.

The coarse dispersion and water may be mixed at one time, or may be mixed while adding the other little by little. The coarse dispersion and water or the like may be simply mixed, and examples of the mixing method include mixing by stirring.
The mixing ratio of the coarse dispersion and water or the like is not particularly limited, and is from 1/20 to 10/1 as the coarse dispersion / water equivalent ratio (mass basis) from the viewpoint of finer astaxanthin dispersion particles. It is preferably 1/10 to 5/1, more preferably 1/2 to 2/1.
In addition, the coarse dispersion, water, and the like are the ratio of the dispersed phase to the continuous phase in the astaxanthin-containing dispersion from the viewpoint of finer astaxanthin-dispersed particles and stability over time. ) Is preferably mixed at a ratio of 1/1000 to 1/5, more preferably mixed at a ratio of 1/100 to 1/10, and mixed at a ratio of 1/50 to 1/10. More preferably.

As the dispersion treatment in this dispersion treatment step, it is preferable to perform high-pressure emulsification treatment from the viewpoint of miniaturization of astaxanthin dispersion particles.
The high pressure emulsification treatment means a dispersion treatment in which a shearing force of 50 MPa or more is applied to the dispersion. From the viewpoint of finer astaxanthin-dispersed particles, the shearing force applied to the dispersion is preferably 100 MPa or more, and more preferably 180 MPa or more. In the case of a commercially available apparatus, the upper limit value is preferably 300 MPa or less from the viewpoint of temperature rise and pressure resistance.

  The means for the high-pressure emulsification treatment is not particularly limited, and a general high-pressure emulsification apparatus can be used. High-pressure emulsifiers include Ultimateizer HJP-25005 (Sugino Machine Co., Ltd.), Microfluidizer (Microfluidic Disc), Nanomizer (Yoshida Kikai Kogyo Co., Ltd., Gorin Type Homogenizer (APV), Ranier Type Homogenizer (Ranier), High Pressure Homogenizer. High pressure homogenizers such as (Niro Soabi), homogenizer (Sanwa Machinery Co., Ltd.), high pressure homogenizer (Izumi Food Machinery Co., Ltd.), and ultrahigh pressure homogenizer (squid) are mentioned.

  The temperature during the high-pressure emulsification treatment is preferably set to 20 ° C to 80 ° C, and more preferably set to 40 ° C to 70 ° C.

  Although the frequency | count of performing a high pressure emulsification process may be 1 time, in order to improve the uniformity of the whole liquid, it is preferable to perform a high pressure emulsification process 2 times or more, and it is more preferable to perform 2-5 times. In addition, it is preferable from the viewpoint of stably maintaining the particle size of the astaxanthin-dispersed particles that the emulsion, which is an emulsified and dispersed composition, is cooled through some cooler within 30 seconds, preferably within 3 seconds immediately after passing through the chamber. .

  The dispersion process in this dispersion process step may be an ultrasonic dispersion process. From the viewpoint of further enhancing the dispersion effect, it is preferable to perform an ultrasonic dispersion treatment after mixing the coarse dispersion and water and before the high-pressure emulsification treatment. A general ultrasonic dispersion apparatus can be used for the dispersion treatment by applying ultrasonic waves.

  As an ultrasonic dispersion apparatus, ultrasonic homogenizers US-600, US-1200T, RUS-1200T, MUS-1200T (Nippon Seiki Seisakusho Co., Ltd.), ultrasonic processors UIP2000, UIP-4000, UIP-8000, UIP -16000 (above, heelsher). These ultrasonic dispersion apparatuses can be used at a frequency of 25 kHz or less, preferably 15 kHz to 20 kHz.

  The preparation method of the astaxanthin-containing dispersion may include other steps as necessary in addition to the preliminary dispersion treatment step and the main dispersion treatment step described above.

  Means for mixing the astaxanthin-containing dispersion obtained as described above, a mixture of the specific compound (1), trimethylglycine and water, and means for mixing the specific compound (1), trimethylglycine and water are: There is no particular limitation, and any commercially available mixing means may be used. Examples of the mixing means include a stirrer, paddle mixer, impeller mixer, homomixer, dispermixer, ultramixer, high pressure homogenizer, ultrasonic homogenizer, and the like. Among the mixing means, at least one selected from a homomixer and a disper mixer is preferable.

The temperature at the time of mixing each component is not specifically limited, A suitable range can be set suitably, and it is preferable to set normally in the range of 4 to 80 degreeC.
The stirring conditions for mixing the components are not particularly limited as long as the components can be sufficiently mixed, and can be appropriately set according to the mixing means. For example, when a homogenizer is used as the mixing means, each component can usually be stirred at 500 rpm (rotation / minute) to 8000 rpm for 5 minutes to 60 minutes.

  In the method for producing a gel cosmetic according to the present invention, after mixing the specific compound (1), trimethylglycine and water, the resulting mixture is cooled, and then the astaxanthin-containing dispersion is blended and further mixed. preferable. The cooling temperature is not particularly limited, and can be appropriately set in consideration of the suppression of crystallization of astaxanthin, and is usually preferably set within a range of 4 ° C to 50 ° C.

  The method for producing an aqueous gel cosmetic of the present invention may include other steps than the above steps as necessary. Examples of other processes include a defoaming process, a heat sterilization process, a cooling process, and a removal process. Methods known in the art may be applied to the defoaming step, heat sterilization step, cooling step, take-out step, and the like.

  EXAMPLES Hereinafter, the present invention will be described more specifically with reference to examples. However, the present invention is not limited to the following examples unless it exceeds the gist thereof.

[Preparation of aqueous gel cosmetics]
[Comparative Example 1]
As the specific compound (1), 1.7 g of PEG-240 / decyltetradeces-20 / HDI copolymer (Adecanol GT-700, ADEKA), trisodium ascorbyl phosphate palmitate (Apressie APPS, Showa Denko) 0 0.5 g, 0.25 g of phosphoric acid 2Na, 6.0 g of glycerin, 0.5 g of trimethylglycine, 0.2 g of ethylhexylglycerin, 0.7 g of 1,3-butylene glycol, 0.5 g of phenoxyethanol, 35 g of pure water was mixed. The obtained mixture was heated to 60 ° C. and stirred for 5 minutes at 2000 rpm using a homogenizer (model name: Homomixer HM-310, ASONE Co., Ltd.). A mixture was obtained.

  Next, 0.22 g of the astaxanthin-containing emulsion composition prepared in advance by the following method and 0.1 g of the lycopene-containing emulsion composition prepared in advance by the following method were prepared in advance by the following method. Ceramide-containing dispersion composition A 6.0 g, ceramide-containing dispersion composition B 0.1 g, water-soluble collagen 0.1 g, hydrolyzed collagen 0.1 g, acetylhydroxyproline 0.1 g, and a trace amount of hydrolyzed white vanilla lupine After adding protein and fragrance | flavor 0.1g, and adding further the pure water of the quantity used as 100g in total quantity, it is 2000 rpm using a homogenizer (model name: Homomixer HM-310, ASONE Co., Ltd.). After stirring for 20 minutes, vacuum defoaming was performed to obtain the aqueous gel cosmetic of Example 1.

<Preparation of an astaxanthin-containing emulsion composition>
The following components were heated at 70 ° C. for 1 hour and dissolved to obtain an aqueous phase composition A.
-Composition of aqueous composition A-
・ Sucrose stearate (HLB = 16) 33.0 g
・ Decaglyceryl monooleate (HLB = 12) 67.0 g
・ Glycerin 450.0g
・ Pure water 300.0g

The following components were heated at 70 ° C. for 1 hour and dissolved to obtain an oil phase composition A.
-Composition of oil phase composition A-
・ Astaxanthin-containing oil 15.0g
(Product name: ASTOTS-S (derived from Haematococcus algae, containing astaxanthin: 20% by mass), Takeda Shiki Co., Ltd.)
・ Mixed tocopherol 32.0g
(Product name: Riken E Oil 800, Riken Vitamin Co., Ltd.)
・ Medium chain fatty acid glyceride 93.0 g
(Product name: Coconut (registered trademark) MT, Kao Corporation)
・ Lecithin 10.0g
(Product name: Recion P, derived from soybean, Riken Vitamin Co., Ltd.)

The obtained aqueous phase composition A was stirred at 10000 rpm using an ultrasonic homogenizer (model: HP93, SMT Co., Ltd.) while maintaining the temperature at 70 ° C., and the oil phase composition A was added to roughly emulsify. I got a thing.
Next, the obtained crude emulsion was cooled to about 40 ° C., and high pressure emulsification was performed at a pressure of 200 MPa using an ultrahigh pressure emulsifier (model name: Ultimateizer HJP-25005, Sugino Machine Co., Ltd.). Then, it filtered using the micro filter with an average hole diameter of 1 micrometer, and obtained the astaxanthin containing emulsion composition (astaxanthin content rate: 0.3 mass%).

  The obtained astaxanthin-containing emulsion composition was diluted with milliQ water in an amount of 1% by mass, and dispersed particles were measured using a particle size analyzer (model: FPAR-1000, Otsuka Electronics Co., Ltd.). The particle diameter was measured and found to be 58 nm (median diameter (d50)).

<Preparation of lycopene-containing emulsion composition>
The following components were heated and mixed with stirring in a constant temperature bath at 70 ° C. to obtain an aqueous phase composition B.
-Composition of aqueous phase composition B-
・ Decaglyceryl oleate-10 8.0 g
(Product name: Decaglyn 1-OV, HLB = 12.0, Nikko Chemicals Corporation)
・ Sucrose stearate 2.0g
(Product name: Ryoto Sugar Ester S-1670, Mitsubishi Chemical Foods Corporation)
・ Glycerin 45.0g
・ Remaining amount of pure water up to 100g

The following components were heated and mixed for 5 minutes while stirring on a 150 ° C. hot plate to obtain an oil phase composition B.
-Composition of oil phase composition B-
・ Tomato oleoresin 1.14g
(Product name: Lyc-O-Mato (registered trademark) 15% (containing lycopene: 15% by mass), Sunbright Co., Ltd.)
・ Lecithin 1.0g
(Product name: Recion P, derived from soybean, Riken Vitamin Co., Ltd.)
・ Medium chain fatty acid glyceride 12.8g
(Product name: Coconut (registered trademark) MT, Kao Corporation)

The obtained aqueous phase composition B is added to the oil phase composition B, mixed with stirring, and dispersed using an ultrasonic homogenizer (model: US-150T, Nippon Seiki Co., Ltd.) to obtain a crude emulsion. It was.
Subsequently, the obtained crude emulsion was further subjected to high pressure emulsification at a pressure of 200 MPa using an ultrahigh pressure emulsifier (model name: Ultimateizer HJP-25005, Sugino Machine Co., Ltd.), and a lycopene-containing emulsion composition ( Lycopene content: 0.17% by mass).

  The obtained lycopene-containing emulsified composition is diluted with milli-Q water in an amount of 1% by mass, and dispersed particles are dispersed using a particle size analyzer (model: FPAR-1000, Otsuka Electronics Co., Ltd.). When the diameter was measured, it was 52 nm (median diameter (d50)).

<Preparation of Ceramide-containing Dispersion Composition A>
The following components were stirred at room temperature for 1 hour to obtain an oil phase composition.
-Composition of oil phase composition-
・ Ceramide 3 0.1g
・ Ceramide 6 0.1g
・ Phytosphingosine 0.07g
・ Ethanol 150g
-1 mol / L hydrochloric acid (adjusted so that pH immediately after dispersion is 7 or less)

  Micromixing the obtained oil phase composition (oil phase) and pure water (aqueous phase) at a ratio (mass ratio) of 1: 7 using a collision type KM micromixer 100/100 A dispersion was obtained. The conditions for using the micromixer are as follows.

<Usage conditions of micromixer>
-Microchannel-
Oil phase side microchannel cross-sectional shape / width / depth / length = rectangle / 70 μm / 100 μm / 10 mm
Water phase side microchannel cross-sectional shape / width / depth / length = rectangle / 490 μm / 100 μm / 10 mm
-Flow rate-
The aqueous phase is 21.0 ml / min. The oil phase was introduced at a flow rate of 3.0 ml / min. Introduced at a flow rate of

  Using the centrifugal thin film vacuum evaporator (model name: Evapor PEP-lab, Okawara Seisakusho Co., Ltd.), the resulting dispersion was desolvated and dispersed until the ethanol concentration was 0.1% by mass or less. Concentration was adjusted until the product concentration reached 2.0% by mass to obtain ceramide-containing dispersion composition A. The dispersion concentration referred to here is a concentration based on the total amount of solids added to the oil phase.

<Preparation of Ceramide-containing Dispersion Composition B>
39.5 g of Liquid A having the following composition was stirred and mixed at 110 ° C. for 10 minutes to obtain a coarse dispersion. The obtained coarse dispersion was cooled to 100 ° C., and after adding B solution in which 60.51 g of the following composition was dissolved at 70 ° C., an ultrasonic homogenizer (model: US-600, Nippon Seiki Seisakusho Co., Ltd.) Was used for 3 minutes to obtain a coarse dispersion. Subsequently, after the obtained coarse dispersion was cooled to about 60 ° C., it was emulsified (dispersed) at a pressure of 245 MPa using an ultrahigh pressure emulsifier (model name: Ultimateizer HJP-25005, Sugino Machine Co., Ltd.). ) To obtain a ceramide-containing dispersion composition B.

[Liquid A]
-Ceramide 1 0.3 parts by mass (acyl ceramide, trade name: Ceramide I, INCI name: Ceramide 1, Evonik)
・ Cholesterol 0.3 parts by mass (trade name: Cholesterol JSQI, Nippon Seika Co., Ltd.)
・ 1,3-butylene glycol (Daicel Co., Ltd.) 0.9 parts by massDecaglycerin monomyristic acid ester 3.0 parts by mass (nonionic surfactant, trade name: NIKKOL (registered trademark) Decaglyn 1-M, (HLB: 14.0, Nikko Chemicals Corporation)
・ Glycerin (concentrated glycerin for makeup, Kao Corporation) 35.0 parts by mass

[Liquid B]
・ Lecithin 4.0 parts by mass (anionic surfactant, trade name: SLP-PC70, Sakai Oil Co., Ltd.)
・ 0.01 parts by mass of propynyl butylcarbamate iodide (trade name: GLYCACIL, Lonza Japan Co., Ltd.)
・ Pure water 56.5 parts by mass

[Examples 1 to 5]
Examples 1 to 5 were carried out in the same manner as in Comparative Example 1 except that the components and contents used in the aqueous gel cosmetic of Comparative Example 1 were changed to the components and contents (g) shown in Table 1 below. The aqueous gel cosmetic of Example 5 was obtained.

[Comparative Example 2]
The aqueous gel cosmetic of Comparative Example 2 was obtained in the same manner as in Comparative Example 1 except that the aqueous gel cosmetic of Comparative Example 1 did not contain trimethylglycine.

[Comparative Example 3]
In the aqueous gel cosmetic of Example 2, 2.0 g of trimethylglycine was replaced with lauryl betaine having a content equal to the number of moles of trimethylglycine in the same manner as in Example 1 except that the aqueous of Comparative Example 3 was used. A gel cosmetic was prepared. However, a stable gel could not be formed.

[Comparative Example 4]
Comparative Example 4 was carried out in the same manner as in Example 1 except that 2.0 g of trimethylglycine was replaced with cocamidopropyl betaine having a content equivalent to the number of moles of trimethylglycine in the aqueous gel cosmetic of Example 2. An aqueous gel cosmetic was prepared. However, a stable gel could not be formed.

[Comparative Example 5]
In the aqueous gel cosmetic of Example 2, the aqueous gel cosmetic of Comparative Example 5 was prepared in the same manner as in Example 1 except that 2.0 g of trimethylglycine was changed to 20 g of trimethylglycine. However, a stable gel could not be formed.

[Examples 6 to 16]
Example 6 was carried out in the same manner as in Comparative Example 1 except that the components and contents used in the aqueous gel cosmetic of Comparative Example 1 were changed to the components and contents (g) shown in Tables 2 to 3. -The aqueous gel cosmetic of Example 16 was obtained.

[Measurement of total content of elements selected from Na and K]
Each of the aqueous gel cosmetics of Examples 1 to 16 and Comparative Examples 1 to 2 immediately after the preparation is analyzed by the following method, and an element selected from Na and K contained in the total amount of the aqueous gel cosmetics. The total content of was measured. Details of the measurement conditions are shown below. In addition, about the comparative example 3-the comparative example 5, since the stable water-based gel-like cosmetics were not obtained, it has not measured.

"Measurement condition"
Add 14 mol / L nitric acid to 0.3 g of the resulting aqueous gel cosmetic, add ion-exchanged water until the volume reaches 3 mL, make the volume up, and wet ash the resulting liquid using microwaves. Treatment was performed to remove moisture. The wet ashing treatment was carried out by treating at 230 ° C. with microwaves. Thereafter, ion-exchanged water is added to the obtained ashed product to make a volume up to 30 mL, and a high frequency inductively coupled plasma emission spectrometer (ICP-OES: Optima 7300DV: commodity) Name, manufactured by Perkin Elmer), the total content of Na element and K element was measured. The measurement results of the total content (mass%) of Na element and K element with respect to the total amount of the aqueous gel cosmetic are shown in Tables 1 to 3 below.

[Evaluation]
[Concentration stability over time]
100 g of each of the aqueous gel cosmetics of Example 1 to Example 16 and Comparative Example 1 to Comparative Example 2 immediately after preparation were put in a glass container having a diameter of 47 mm and a height of 90 mm, respectively, and capped, at 50 ° C. Stored for 6 and 8 weeks. Each aqueous gel cosmetic after storage was visually observed and the change in concentration of the gel cosmetic was evaluated according to the following evaluation criteria. In the following evaluation criteria, ranks up to rank B are practically acceptable levels, and rank C is a level that is practically unacceptable. In Comparative Examples 3 to 5, since a stable aqueous gel cosmetic was not obtained, the stability with time of concentration and the evaluation of gel stability were not evaluated.
(Evaluation criteria)
A: The gel is transparent and uniform. B: A portion with a high local color density cannot be confirmed visually, but a part of the portion is slightly cloudy. C: A local portion is observed in the transparent gel. The color density was high, and the reddish black part was clearly confirmed

[Gel stability: Stability of hardness over time]
100 g of each of the aqueous gel cosmetics of Examples 1 to 16 and Comparative Examples 1 to 2 immediately after preparation were put into glass containers each having a diameter of 47 mm and a height of 90 mm, and capped, at 25 ° C. Stored for 24 hours. The hardness of each aqueous gel cosmetic after storage (hereinafter referred to as “initial hardness” as appropriate) was measured using a rheometer (model name: FUDOH REHOMETER, Rheotech Co., Ltd.). Specifically, for each aqueous gel cosmetic, the stress measured when the tip of an adapter with a diameter of 20 mm is inserted with a load of 2 kg at a speed of 60 mm / min at a measurement temperature of 25 ° C. Was the hardness measurement (unit: g). Details of the measurement conditions are shown below.

"Measurement condition"
Adapter: No. 3 (Diameter: 20mm)
Load: 2kg
Speed: 60mm / min Measurement temperature: 25 ° C
No load base: 0.1%
Sampling interval: 0.02 seconds X-axis table travel distance: 20 mm (forced termination: 20 mm)

As another system, 100 g of each of the aqueous gel cosmetics of Example 1 to Example 16 and Comparative Example 1 to Comparative Example 2 immediately after preparation are put in a glass container having a diameter of 47 mm and a height of 90 mm, respectively, and a cap is put on. And stored at 50 ° C. for 2 weeks. The hardness of each aqueous gel cosmetic after storage at 50 ° C. for 2 weeks (hereinafter referred to as “time-dependent hardness” as appropriate) was measured by the same method as the above initial hardness.
Then, using the measured values of initial hardness and hardness over time, the rate of change in hardness over time is calculated, and based on the obtained rate of change in hardness, according to the following evaluation criteria, the gel stability in an aqueous gel cosmetic is: The stability with time of hardness was evaluated. "Hardness change rate over time" was obtained by dividing the higher value of the measured values of initial hardness and time-dependent hardness by the lower value and rounding off the second decimal place to the first decimal place. Value.
The smaller the rate of change in hardness over time, the better the storage stability of the aqueous gel cosmetic, and level C was evaluated as a practically problematic level.

(Evaluation criteria)
AAA: Hardness change rate over time is 1.0 or more and less than 1.5 AA: Hardness change rate over time is 1.5 or more and less than 2.0 A: Hardness change rate over time is 2.0 B: Hardness change rate over time is 3.0 or more and less than 4.0 C: Hardness change rate over time is 4.0 or more

[Evaluation of feeling of use (stickiness)]
The presence or absence of stickiness when applied to the skin was evaluated as one of the indicators of the feeling of use.
100 g of each of the aqueous gel cosmetics of Examples 1 to 16 and Comparative Examples 1 to 2 immediately after preparation were put into glass containers each having a diameter of 47 mm and a height of 90 mm, and capped, at 25 ° C. Stored for 24 hours. Each water-based gel cosmetic after storage is used by 10 specialist panelists for cosmetic evaluation, and 0.5 g of cosmetic is applied to the entire face using the palm of the hand for 1 minute. The touch was evaluated by touching the cheek with a hand and releasing the hand. In addition, about the comparative example 3-the comparative example 5, since the stable water-based gel-like cosmetics were not obtained, the usability | use_condition is not evaluated.
AA: 8-10 out of 10 people feel that their skin is sticking to their hands, and that there is no stickiness A: 5-7 of 10 people feel that their skin sticks to their hands Yes, B: Evaluated that there was no stickiness B: 3 to 4 out of 10 people felt that the skin was sticking to their hands and evaluated that there was no stickiness C: Evaluated that there was no stickiness in 10 people Was less than 2

[Evaluation of feeling of use (moisturizing feeling)]
One minute after applying 0.5 g palm on the entire face, the skin surface was evaluated for whether there was a feeling of film-like residue.
AA: 8 to 10 out of 10 people evaluated that the moist feel remained on the skin surface A: 5 to 7 out of 10 people evaluated that the moist feel remained on the skin surface B: 10 people Three to four persons evaluated that the moist feel remained on the skin surface. C: Out of ten persons, less than two persons evaluated that the moist feel remained on the skin surface. Are shown in Tables 1 to 3 below.
In addition, "-" in Tables 1 to 3 means that the gel cosmetic does not contain the corresponding compound.

As shown in Tables 1 to 3, the aqueous gel cosmetics of Examples 1 to 16 are all suppressed in local concentration change with time and stable over time as a gel cosmetic. It was excellent, the feeling of use as a cosmetic was not sticky, and the durability of the moisturizing feeling was good.
On the other hand, the aqueous gel cosmetic of Comparative Example 1 that does not contain trimethylglycine and Comparative Example 2 in which the content of trimethylglycine is less than the range defined in the present invention has good gel stability over time. A local concentration change was observed, and the deterioration of the appearance was at a level causing a practical problem. In Comparative Example 3 and Comparative Example 4 using lauryl betaine and cocamidopropyl betaine which are betaine-type amphoteric surfactants instead of trimethylglycine, and in Comparative Example 5 in which the content of trimethylglycine exceeds 10% by mass, stable A gel was not formed, and an aqueous gel cosmetic could not be prepared.

Claims (5)

Astaxanthin, trimethylglycine and the compound represented by the following general formula (1) are contained in the following content with respect to the total amount of the aqueous gel cosmetic, and the total of elements selected from Na and K relative to the total amount of the aqueous gel cosmetic An aqueous gel cosmetic having a content of 0.05% by mass or more.
Astaxanthin: 1 ppm to 100 ppm
Trimethylglycine: 1% to 10% by mass
Compound represented by the following general formula (1): 0.5% by mass to 5% by mass


In the general formula (1), R ¹ represents an m-valent hydrocarbon group having ² to 36 carbon atoms, R ² and R ⁴ each independently represents a divalent hydrocarbon group having 1 to 4 carbon atoms, R ³ represents a straight chain, branched chain, or h + 1 valent hydrocarbon group containing an aliphatic ring or an aromatic ring, which may have a urethane bond, R ⁵ represents a divalent hydrocarbon group, and R ⁶ represents Represents a hydrogen atom or a hydroxy group. m is an integer greater than or equal to 2, h is an integer greater than or equal to 1, k and n represent the repeating number of the structure in a parenthesis, and are each independently an integer of the range of 0-1000, both k and n Will never be zero.   The aqueous gel cosmetic according to claim 1, wherein the content of astaxanthin relative to the total amount of the aqueous gel cosmetic is 10 ppm to 100 ppm.   Claim 1 or Claim containing at least one compound selected from the group consisting of trisodium ascorbyl palmitate, sodium tocopheryl phosphate, sodium isostearate, potassium isostearate, sodium oleate, and potassium oleate. 2. The aqueous gel cosmetic as described in 2.   The aqueous gel cosmetic according to any one of claims 1 to 3, comprising at least one compound selected from the group consisting of citrate and phosphate.   The aqueous gel cosmetic according to claim 4, comprising at least one compound selected from phosphates.