JP2016145228A - アミノ酸結晶の製造方法及びタンパク質結晶の製造方法 - Google Patents
アミノ酸結晶の製造方法及びタンパク質結晶の製造方法 Download PDFInfo
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Abstract
光渦の新たな応用の可能性を提供する。
【解決手段】
本発明の一観点にかかるアミノ酸結晶の製造方法は、光渦を、アミノ酸飽和溶液に照射して、アミノ酸飽和溶液中にアミノ酸結晶を形成することを特徴とする。
また、本観点において、限定されるわけではないが、アミノ酸は、アラニン、アルギニン、アスパラギン、アスパラギン酸、システイン、グルタミン、グルタミン酸、グリシン、ヒスチジン、イソロイシン、ロイシン、リシン、メチオニン、フェルアラニン、プロリン、セリン、トレオニン、トリプトファン、チロシン及びバリン、並びにこれらの誘導体、の少なくともいずれかの少なくともいずれかであることが好ましい。
【選択図】図1
Description
まず、図1で示される光学系において、中心波長1064nmのNd:YVO4レーザーを、螺旋状位相板(SPP)とλ/4板、対物レンズ(NA〜0.65)を使用し、これらを通してグリシンを重水に溶解度まで溶解させたアミノ酸飽和重水溶液(プレパラート上に塗布)に照射した。アミノ酸飽和重水溶液に照射しているレーザーのスポットの径はφ3μmとした。また円偏光の向きと光渦の螺旋波面の向きは同じ方向に設定した。なお円偏光光渦は、SPPによって得られる軌道角運動量(l=−1又は1)とQWPによって得られるスピン角運動量(s=−1又は1)の総和である全角運動量(J=l+s)の大きさを変更して照射することができる構成となっている。
この結果を図2にそれぞれ示しておく。
上記グリシンの例において、レーザーを直線偏光のガウスビームを用いた以外は同様の条件でアミノ酸の結晶の作成を試みた。この結果を図3に示しておく。この結果によると、アミノ酸は析出したが明らかに多結晶のものであった。
Claims (5)
- 光渦を、アミノ酸飽和溶液に照射して、前記アミノ酸飽和溶液中にアミノ酸の結晶を形成する、アミノ酸結晶の製造方法。
- 前記アミノ酸は、アラニン、アルギニン、アスパラギン、アスパラギン酸、システイン、グルタミン、グルタミン酸、グリシン、ヒスチジン、イソロイシン、ロイシン、リシン、メチオニン、フェルアラニン、プロリン、セリン、トレオニン、トリプトファン、チロシン及びバリン、並びにこれらの誘導体、の少なくともいずれかである請求項1記載のアミノ酸結晶の製造方法。
- 前記光渦は、円偏光である請求項1記載のアミノ酸結晶の製造方法。
- 光渦を、タンパク質飽和溶液に照射して、前記タンパク質飽和溶液中にタンパク質の結晶を形成する、タンパク質結晶の製造方法。
- 前記光渦は、円偏光である請求項4記載のタンパク質結晶の製造方法。
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JP2016040541A Active JP6457412B2 (ja) | 2014-08-31 | 2016-03-03 | アラニン、アルギニン、アスパラギン、アスパラギン酸、システイン、グルタミン、グルタミン酸、ヒスチジン、イソロイシン、ロイシン、リシン、メチオニン、フェルアラニン、プロリン、セリン、トレオニン、トリプトファン、チロシン又はバリンの結晶の製造方法 |
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WO2013055859A1 (en) * | 2011-10-11 | 2013-04-18 | Kadir Aslan | Metal-assisted and microwave-accelerated evaporative crystallization |
JP5924723B1 (ja) * | 2014-08-31 | 2016-05-25 | 国立大学法人 千葉大学 | アミノ酸結晶の製造方法及びタンパク質結晶の製造方法 |
Non-Patent Citations (4)
Title |
---|
"Crystal structure control in the non-photochemical laser-induced nucleation of supersaturated aqueou", ABSTRACTS OF PAPERS, 223RD ACS NATIONAL MEETING, ORLANDO, FL, UNITED STATES, vol. April 7-11, 2002 (2002), JPN7016003213, 2002, ISSN: 0003428040 * |
"Nonphotochemical, laser-induced nucleation of supersaturated aqueous glycine produces unexpected γ-", CRYSTAL GROWTH & DESIGN, vol. (2001), 1(1), p.5-8, JPN7016003212, 2001, ISSN: 0003428039 * |
JEFFRIES, G. M. ET AL., J. PHYS. CHEM. B, vol. 111, JPN6016001098, 2007, pages 2806 - 2812, ISSN: 0003428038 * |
川喜多哲哉: "アミノ酸の結晶化", 日本結晶成長学会誌, vol. v23(3), JPN7017001624, 1996, JP, pages 218, ISSN: 0003562450 * |
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