JP2016098199A - Aqueous composition - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide an aqueous composition by using surfactin salt, where the aqueous composition is stable in a low pH area and has excellent transparency and low viscosity.SOLUTION: An aqueous composition comprises following components (A)-(D) and has pH of 2.5 or more and 6 or less: (A) C1-C3 saturated monohydric alcohol 25-55 mass%; (B) divalent alcohol 5-25 mass%; (C) surfactin or salt thereof; and (D) organic acid or salt thereof.SELECTED DRAWING: None

Description

  The present invention relates to a stable aqueous composition containing surfactin or a salt thereof.

  In recent years, in consideration of sustainability and environmental considerations, the use of surfactants that do not contain petroleum-derived components in their structures and that are produced by highly biodegradable microorganisms, so-called biosurfactants, for external preparations for skin has been studied.

  As biosurfactants used for external preparations for skin, surfactin salts, mannosyl erythritol lipids, sophorolipids, etc. are known, and in particular, surfactin salts are also approved as quasi-drugs, One of the highly anticipated biosurfactants.

  Surfactin is a substance derived from the culture solution of Bacillus subtilis, named by Arima et al. At the University of Tokyo and whose structure has been determined by Kakinuma et al., And is a lipopeptide having a cyclic peptide as a hydrophilic part and an alkyl side chain as a hydrophobic part. It is a peptide. Aspartic acid and glutamic acid in the cyclic peptide have a free carboxyl group, and the sodium salt has a function as an anionic surfactant. It has been reported that it has not only the ability as a surfactant but also physiological effects such as inhibition of growth of acne bacteria (see Non-Patent Document 1). It is also a biosurfactant that has been highly anticipated as a base for external use because it has a formulation approval as a quasi-drug.

  In recent years, prescription application to skin external preparations has progressed. For example, a skin external preparation containing a surfactin salt and adjusting the pH of the final composition to 6.5 to 9.0 (see Patent Document 1), Surfactin Excellent storage stability using a combination of a salt and a carboxyvinyl polymer and / or an alkyl-modified carboxyvinyl polymer, which is excellent in storage stability (see Patent Document 2), or a surfactin salt and a glycerin monofatty acid ester. A milky skin external preparation has been proposed (see Patent Documents 3 to 5).

JP 2004-67647 A JP 2003-95853 A JP 2003-146827 A JP 2003-277220 A JP 2003-277250 A

Abstracts of 2012 Agricultural Chemistry Society Conference

However, as described in Patent Document 1, the surfactin salt has a pH of weakly acidic to acidic in the region where the carboxyl group charge in the peptide chain disappears and the solubility in water decreases. It was difficult to form a low-viscosity aqueous composition in the low pH region because precipitation occurred in the preparation or the surface activity decreased. Therefore, it has been difficult to add an effective amount of a component that exhibits a high effect in an acidic region such as α-hydroxy acid to the aqueous composition containing the surfactin salt.
Accordingly, an object of the present invention is to provide a low-viscosity aqueous composition that uses a surfactin salt, is stable in a low pH region, and has good transparency.

  Therefore, as a result of studying various components in combination with the surfactin salt, the present inventor unexpectedly found that when a dihydric alcohol and a large amount of a saturated monohydric alcohol having 1 to 3 carbon atoms were used in combination with the surfactin salt. The inventors have found that an aqueous composition having a low viscosity and excellent stability even in a low pH region and having an excellent feel during application can be obtained, and the present invention has been completed.

That is, the present invention relates to an aqueous composition containing the following components (A) to (D) and having a pH of 2.5 or more and 6 or less.
(A) C1-C3 saturated monohydric alcohol 25-55 mass%
(B) Dihydric alcohol 5-25 mass%
(C) Surfactin or a salt thereof (D) Organic acid or a salt thereof

  The aqueous composition of the present invention is excellent in stability and transparency in a low pH region, low in viscosity and excellent in use feeling (good elongation and refreshing feeling), and can be suitably used for applications such as cosmetics and pharmaceuticals. .

  Hereinafter, the configuration of the present invention will be described in detail.

The aqueous composition in the present invention is a composition in which the continuous phase is formed from water or an aqueous solution of a water-soluble solvent. The composition which does not contain an oil agent substantially may be sufficient. In addition, the content of the oil agent in the aqueous composition is preferably 3% by mass or less, more preferably 1% by mass or less, and still more preferably 0.6% by mass or less. It is. If it is the said range, it will be excellent in transparency and stability, there will be no stickiness by surfactant, and it will become a refreshing use feeling.
Here, the oil agent is a general term for components that are easily soluble in oils such as fats and oils (triglycerides), ester oils, hydrocarbons, higher alcohols having 8 or more carbon atoms, silicone oils, fluorine oils, and the like that are difficult to dissolve in water. .

  The pH of the aqueous composition of the present invention needs to be 2.5 or more at 25 ° C., preferably 3 or more, from the viewpoint of sufficiently expressing the effect of an organic acid such as α-hydroxy acid or a salt thereof. Moreover, it is necessary that it is 6 or less, Preferably it is 5.6 or less, More preferably, it is 4.5 or less. Specifically, the pH is preferably 2.5 to 6, more preferably 2.5 to 5.6, still more preferably 3 to 5.6, and more preferably 3 to 4.5. More preferably.

  Examples of (A) the saturated monohydric alcohol having 1 to 3 carbon atoms used in the present invention include methyl alcohol, ethyl alcohol, n-propyl alcohol, isopropyl alcohol, etc., preferably saturated monohydric alcohol having 2 or 3 carbon atoms. More preferably, it is ethyl alcohol. These monohydric alcohols can be used alone or in combination of two or more.

  The content of the component (A) in the aqueous composition is not particularly limited, but it improves the refreshing feeling at the time of coating, and 25 to 55% by mass is necessary from the viewpoint of the transparency of the composition. Yes, preferably 28% by mass or more, more preferably 32% by mass, preferably 50% by mass or less, more preferably 48% by mass or less, still more preferably 45% by mass, More preferably, it is 40 mass%. Specifically, it is preferably 28 to 50% by mass, more preferably 32 to 48% by mass, further preferably 32 to 45% by mass, and further preferably 32 to 40% by mass.

As long as (B) dihydric alcohol used for this invention is normally used for cosmetics, it can be especially used without a restriction | limiting. Specifically, ethylene glycol, propylene glycol, 1,3-butylene glycol, 1,2-pentylene glycol, 1,3-pentylene glycol, 1,4-pentylene glycol, 1,5-pentylene glycol, Examples include alkylene glycols such as hexylene glycol; dialkylene glycols such as diethylene glycol and dipropylene glycol. Among these, C2-C10 alkylene glycol and C4-C8 dialkylene glycol are more preferable.
Of these, ethylene glycol, diethylene glycol, propylene glycol, dipropylene glycol, 1,3 propanediol, and 1,3-butylene glycol are preferable, and diethylene glycol and dipropylene glycol are more preferable from the viewpoint of transparency and usability of the preparation. Dipropylene glycol is more preferable. These dihydric alcohols can be used alone or in combination of two or more.

  The content of the component (B) in the aqueous composition needs to be 5 to 25% by mass, preferably 5% by mass or more, preferably 24% by mass or less, more preferably 20% by mass or less, 16 A mass% or less is more preferable. Specifically, it is 5-24 mass%, More preferably, it is 5-20 mass%, More preferably, it is 5-16 mass%. If it is in the said range, a moist feeling is favorable and there is neither a squeaky feeling nor a sticky feeling, which is preferable.

  The content ratio ((A) / (B)) of the component (A) and the component (B) in the aqueous composition of the present invention is preferably 1.2 or more from the viewpoint of suppressing precipitation of the component (C). 1.5 or more is more preferable, 2 or more is more preferable, 10 or less is preferable, 7 or less is more preferable, and 4 or less is more preferable. As a specific range of (A) / (B), 1.2 to 10 is preferable, 1.5 to 10 is more preferable, 2 to 7 is more preferable, and 2 to 4 is more preferable.

(C) Surfactin or a salt thereof used in the present invention is a known substance, such as Bacillus subtilis IAM 1213 strain, IAM 1069 strain, IAM 1259 strain, IAM 1260 strain, IFO 3035 strain, ATCC 21332 strain. It is a natural surfactant produced by Bacillus microorganisms. Surfactin salts include metal salts of amino acid-derived carboxyl groups (alkali metal salts such as sodium, potassium and lithium, alkaline earth metal salts such as calcium and magnesium, etc.) and organic ammonium salts (trimethylamine). Salt, triethylamine salt, tributylamine salt, monoethanolamine salt, diethanolamine salt, triethanolamine salt, lysine salt, arginine salt, choline salt).
Of these, surfactin sodium (trade name: Kaneka Surfactin; manufactured by Kaneka Corporation) is preferably used from the viewpoint of easy availability in the market.

  The content of the component (C) in the aqueous composition of the present invention is preferably 0.05% by mass or more from the viewpoint of maintaining the functions of a surfactant such as solubilization of fragrances and prevention of precipitation of plant extracts. .1% by mass or more is more preferable, 5% by mass or less is preferable, and 2% by mass or less is more preferable. As a specific range, 0.05-5 mass% is preferable and 0.1-2 mass% is more preferable.

  Examples of the organic acid (D) or salt thereof used in the present invention include linear or branched, saturated or unsaturated fatty acids, and alicyclic carboxylic acids, and any position of these organic acids. A hydroxy acid substituted with a hydroxyl group can be preferably used. Among these, α-hydroxy acid is more preferable, and specific examples include glycolic acid, lactic acid, glyceric acid, malic acid, tartaric acid, and citric acid. Furthermore, citric acid is more preferable from the viewpoint of irritation. These salts include metal salts (alkali metal salts such as sodium, potassium and lithium, alkaline earth metal salts such as calcium and magnesium) and organic ammonium salts (trimethylamine salt, triethylamine salt, tributylamine salt, mono Ethanolamine salt, diethanolamine salt, triethanolamine salt, lysine salt, arginine salt, choline salt, etc.).

  The content of the component (D) in the aqueous composition of the present invention is not particularly limited as long as the pH of the aqueous composition is in the above range, but from the viewpoint of a moisturizing effect and a buffering effect, 0.05. % By mass or more is preferable, 0.1% by mass or more is more preferable, 5% by mass or less is preferable, 2% by mass or less is more preferable, and 1% by mass or less is more preferable. As a specific range, 0.05-5 mass% is preferable, 0.1-2 mass% is more preferable, 0.1-1 mass% is further more preferable.

  In the aqueous composition of the present invention, the content of water is not particularly limited, but is preferably 44.9 to 69.9% by mass and more preferably 45 to 60% by mass from the viewpoint of a refreshing feel and freshness.

  The viscosity of the aqueous composition of the present invention is that of a B-type viscometer (Bismetron viscometer: model VS-A1 (manufactured by Shibaura System), rotor No. 4, 12 rotations from the viewpoint of penetrating skin and refreshing feel. / Min, 30 seconds) at 1 atm and 25 ° C., preferably 1 to 500 mPa · s, more preferably 50 to 400 mPa · s, and further preferably 100 to 350 mPa · s. preferable.

  The aqueous composition of the present invention is, in addition to the above essential components, other optional components usually used in pharmaceuticals, quasi-drugs, cosmetics and the like as long as the effects of the present invention are not impaired as necessary. For example, anionic surfactants other than component (C), cationic surfactants, nonionic surfactants, oils, ultraviolet absorbers, preservatives, moisturizers, polymers, amino acid derivatives, sugar derivatives, fragrances Components other than the components (A) and (B), such as alcohol, thickener, colorant, sequestering agent, antioxidant, and drug can be appropriately blended.

  The use of the aqueous composition of the present invention is not particularly limited, but it is suitable for use as an external preparation for skin (including the scalp) because of its high appearance transparency and good skin feel. The dosage form can be applied to lotions, aqueous essences, packs, aqueous gels, and the like, and can also be applied as a sheet, spray, or mousse. In addition, the transparency in the present application means that the aqueous composition is placed in a glass bottle (500 mL beaker, dimensions: outer diameter 92 mm, height 120 mm, wall thickness 2 mm), and 8-point characters placed behind the glass bottle can be read. If the character can be read, the aqueous composition may have a color.

  In addition to the embodiments described above, the following embodiments are disclosed.

<1> An aqueous composition containing the following components (A) to (D) and having a pH of 2.5 or more and 6 or less.
(A) C1-C3 saturated monohydric alcohol 25-55 mass%
(B) Dihydric alcohol 5-25 mass%
(C) Surfactin or a salt thereof (D) Organic acid or a salt thereof <2> A composition in which the continuous phase is formed of water or an aqueous solution of a water-soluble solvent, and the content of the oil agent is preferably 3% by mass or less The aqueous composition according to <1>, more preferably 1% by mass or less, and still more preferably 0.6% by mass or less.
<3> The aqueous composition according to <1> or <2>, wherein the pH is preferably 3 or more, preferably 5.6 or less, more preferably 4.5 or less at 25 ° C.
<4> The pH is preferably 2.5 to 6, more preferably 2.5 to 5.6, still more preferably 3 to 5.6, and still more preferably 3 to 4.5 at 25 ° C. <1 The aqueous composition according to any one of> to <3>.
<5> Component (A) is preferably a saturated monohydric alcohol having 2 or 3 carbon atoms, more preferably ethyl alcohol or isopropyl alcohol, and further preferably ethyl alcohol. Any aqueous cosmetic.
<6> The content of the component (A) is preferably 28 to 50% by mass, more preferably 32 to 48% by mass, further preferably 32 to 45% by mass, and further preferably 32 to 40% by mass. The aqueous cosmetic composition according to any one of> to <5>.
<7> Component (B) is one or more selected from alkylene glycols having 2 to 10 carbon atoms and dialkylene glycols having 4 to 8 carbon atoms, preferably ethylene glycol, diethylene glycol, propylene glycol, dipropylene glycol The aqueous cosmetic composition according to any one of <1> to <6>, which is one or more selected from 1,3-propanediol, and 1,3-butylene glycol.
The content of <8> component (B) is preferably 5 to 24% by mass, more preferably 5 to 20% by mass, and further preferably 5 to 16% by mass, and any one of <1> to <7> Aqueous cosmetics.
<9> The content of component (C) is preferably 0.05% by mass or more, more preferably 0.1% by mass, and preferably 5% by mass, more preferably 2% by mass or less. <1 The aqueous cosmetic composition according to any one of> to <8>.
<10> The aqueous cosmetic composition according to any one of <1> to <9>, wherein the content of the component (C) is preferably 0.05 to 5 mass%, more preferably 0.1 to 2 mass%.
<11> Component (D) is a linear or branched, saturated or unsaturated fatty acid or alicyclic carboxylic acid or a salt thereof, preferably a hydroxy acid or a salt thereof, more preferably α-hydroxy. Any one of <1> to <10>, which is an acid or a salt thereof, and more preferably one or more selected from glycolic acid, lactic acid, glyceric acid, malic acid, tartaric acid, citric acid, and salts thereof Such water-based cosmetics.
The content of <12> component (D) is preferably 0.05% by mass or more, more preferably 0.1% by mass or more, preferably 5% by mass or less, more preferably 2% by mass or less, The aqueous cosmetic according to any one of <1> to <11>, which is preferably 1% by mass or less.
The content of <13> component (D) is preferably 0.05 to 5% by mass, more preferably 0.1 to 2% by mass, and still more preferably 0.1 to 1% by mass. 12> Aqueous cosmetic preparation according to any one of the above.
<14> The aqueous cosmetic composition according to any one of <1> to <13>, wherein the water content is preferably 44.9 to 69.9% by mass, more preferably 45 to 60% by mass.
<15> The aqueous makeup according to any one of <1> to <14>, wherein the viscosity at 25 ° C. is 1 to 500 mPa · s, preferably 50 to 400 mPa · s, more preferably 100 to 350 mPa · s. Fee.
<16> The aqueous cosmetic composition according to any one of <1> to <15>, wherein the appearance is transparent.

  EXAMPLES Hereinafter, although this invention is demonstrated in detail based on an Example and a comparative example, it is not limited to these. First, test methods used in Examples and Comparative Examples will be described below.

[Appearance evaluation]
One hour after the preparation of the sample, it was put into a glass bottle (500 mL beaker, dimensions: outer diameter 92 mm, height 120 mm, wall thickness 2 mm), visually observed for appearance, and evaluated according to the appearance evaluation criteria.
[Appearance criteria]
○: Transparent (can read 8-point characters placed behind the glass bottle)
Δ: cloudiness (8-point characters placed behind the glass bottle cannot be read)
X: Precipitates or their deposits are observed

[PH measurement]
One hour after the preparation of the sample, the pH of the sample was measured at 25 ° C. using a pH meter (manufactured by Horiba, Model No. F-22).

[Sensory test]
Samples were used by an evaluation panel of 20 adult women, and the moisturizing feeling and squeakiness were evaluated, and the evaluation was performed by the number of people who responded that both feels good.

Examples 1-8, Comparative Examples 1-17
A lotion was prepared with the composition described in Tables 1 to 3, and the sensory test was performed.

[Preparation method]
Components 1 to 11 are mixed and stirred uniformly at room temperature.

Tables 1 to 3 show the appearance observation results and sensory test results of samples in which polyhydric alcohols were added to the surfactin salt and monohydric alcohol system under low pH conditions. As shown in Examples 1 to 3, a dihydric alcohol such as dipropylene glycol, 1,3-butylene bricol, and 1,3-propanediol replaced a part of ethanol, but a clear region was seen. As shown in Comparative Examples 1 to 3, precipitates were observed in trihydric or higher polyhydric alcohols such as glycerin, sorbitol, and maltitol.
As shown in Examples 1 to 8 and Comparative Examples 4 to 6, a skin lotion that is transparent, has a high moisturizing feeling, and does not have a squeaky feeling can be obtained only when the components (A) and (B) are contained in specific amounts. ing.
As shown in Comparative Example 7, when 47.5% by mass of ethanol was contained, a transparent appearance was obtained, but the moisturizing feeling was low and a squeak was felt. In Comparative Examples 8 to 11 having an ethanol content of 38% by mass or less, precipitates were observed. In Comparative Examples 12 to 17 containing 50 mass% of polyhydric alcohol instead of ethanol, precipitates were observed.

  Hereinafter, formulation examples of the present invention will be described. Any prescription is presumed to have the effects of the present invention and to be excellent as a cosmetic.

Formulation Example 1 Whitening serum

Formulation Example 2 Moisturizing serum

Formulation Example 3 Anti-aging serum

Formulation Example 4 Pore Care Essence

Claims (5)

An aqueous composition containing the following components (A) to (D) and having a pH of 2.5 or more and 6 or less.
(A) C1-C3 saturated monohydric alcohol 25-55 mass%
(B) Dihydric alcohol 5-25 mass%
(C) Surfactin or a salt thereof (D) Organic acid or a salt thereof   The component (B) is one or more selected from ethylene glycol, diethylene glycol, propylene glycol, dipropylene glycol, isoprene glycol, 1,3 propanediol and 1,3-butylene glycol. Aqueous composition.   The aqueous composition according to claim 1 or 2, wherein component (D) is an α-hydroxy acid.   The aqueous composition according to any one of claims 1 to 3, wherein the appearance is transparent.   Content of oil agent is 3 mass% or less, The aqueous composition of any one of Claims 1-4.