JP2016088870A - Oral composition - Google Patents
Oral composition Download PDFInfo
- Publication number
- JP2016088870A JP2016088870A JP2014223373A JP2014223373A JP2016088870A JP 2016088870 A JP2016088870 A JP 2016088870A JP 2014223373 A JP2014223373 A JP 2014223373A JP 2014223373 A JP2014223373 A JP 2014223373A JP 2016088870 A JP2016088870 A JP 2016088870A
- Authority
- JP
- Japan
- Prior art keywords
- glucosamine
- weight
- oral composition
- group
- compound
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000000203 mixture Substances 0.000 title claims abstract description 74
- MSWZFWKMSRAUBD-UHFFFAOYSA-N beta-D-galactosamine Natural products NC1C(O)OC(CO)C(O)C1O MSWZFWKMSRAUBD-UHFFFAOYSA-N 0.000 claims abstract description 107
- 229960002442 glucosamine Drugs 0.000 claims abstract description 107
- -1 glucosamine compound Chemical class 0.000 claims abstract description 61
- 230000003110 anti-inflammatory effect Effects 0.000 claims abstract description 50
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 claims abstract description 25
- 150000001413 amino acids Chemical class 0.000 claims abstract description 25
- 239000011593 sulfur Substances 0.000 claims abstract description 25
- 229910052717 sulfur Inorganic materials 0.000 claims abstract description 25
- MSWZFWKMSRAUBD-IVMDWMLBSA-N 2-amino-2-deoxy-D-glucopyranose Chemical compound N[C@H]1C(O)O[C@H](CO)[C@@H](O)[C@@H]1O MSWZFWKMSRAUBD-IVMDWMLBSA-N 0.000 claims description 56
- 102000016611 Proteoglycans Human genes 0.000 claims description 28
- 108010067787 Proteoglycans Proteins 0.000 claims description 28
- 235000001014 amino acid Nutrition 0.000 claims description 24
- 150000003839 salts Chemical class 0.000 claims description 17
- XOAAWQZATWQOTB-UHFFFAOYSA-N taurine Chemical compound NCCS(O)(=O)=O XOAAWQZATWQOTB-UHFFFAOYSA-N 0.000 claims description 17
- 238000004519 manufacturing process Methods 0.000 claims description 15
- XUJNEKJLAYXESH-REOHCLBHSA-N L-Cysteine Chemical compound SC[C@H](N)C(O)=O XUJNEKJLAYXESH-REOHCLBHSA-N 0.000 claims description 11
- FFEARJCKVFRZRR-BYPYZUCNSA-N L-methionine Chemical compound CSCC[C@H](N)C(O)=O FFEARJCKVFRZRR-BYPYZUCNSA-N 0.000 claims description 10
- XUJNEKJLAYXESH-UHFFFAOYSA-N cysteine Natural products SCC(N)C(O)=O XUJNEKJLAYXESH-UHFFFAOYSA-N 0.000 claims description 9
- 235000018417 cysteine Nutrition 0.000 claims description 9
- 229930182817 methionine Natural products 0.000 claims description 9
- 229960003080 taurine Drugs 0.000 claims description 8
- 206010061218 Inflammation Diseases 0.000 claims description 6
- OVRNDRQMDRJTHS-UHFFFAOYSA-N N-acelyl-D-glucosamine Natural products CC(=O)NC1C(O)OC(CO)C(O)C1O OVRNDRQMDRJTHS-UHFFFAOYSA-N 0.000 claims description 6
- OVRNDRQMDRJTHS-FMDGEEDCSA-N N-acetyl-beta-D-glucosamine Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O OVRNDRQMDRJTHS-FMDGEEDCSA-N 0.000 claims description 6
- MBLBDJOUHNCFQT-LXGUWJNJSA-N N-acetylglucosamine Natural products CC(=O)N[C@@H](C=O)[C@@H](O)[C@H](O)[C@H](O)CO MBLBDJOUHNCFQT-LXGUWJNJSA-N 0.000 claims description 6
- 229950006780 n-acetylglucosamine Drugs 0.000 claims description 6
- 229940126062 Compound A Drugs 0.000 claims description 2
- NLDMNSXOCDLTTB-UHFFFAOYSA-N Heterophylliin A Natural products O1C2COC(=O)C3=CC(O)=C(O)C(O)=C3C3=C(O)C(O)=C(O)C=C3C(=O)OC2C(OC(=O)C=2C=C(O)C(O)=C(O)C=2)C(O)C1OC(=O)C1=CC(O)=C(O)C(O)=C1 NLDMNSXOCDLTTB-UHFFFAOYSA-N 0.000 claims description 2
- 238000000034 method Methods 0.000 abstract description 28
- 229920001542 oligosaccharide Polymers 0.000 abstract description 8
- 230000000694 effects Effects 0.000 description 15
- 229920001287 Chondroitin sulfate Polymers 0.000 description 12
- 230000002708 enhancing effect Effects 0.000 description 12
- SQDAZGGFXASXDW-UHFFFAOYSA-N 5-bromo-2-(trifluoromethoxy)pyridine Chemical compound FC(F)(F)OC1=CC=C(Br)C=N1 SQDAZGGFXASXDW-UHFFFAOYSA-N 0.000 description 10
- 230000009471 action Effects 0.000 description 10
- 229940059329 chondroitin sulfate Drugs 0.000 description 10
- 235000013305 food Nutrition 0.000 description 9
- 230000000202 analgesic effect Effects 0.000 description 8
- 239000000284 extract Substances 0.000 description 8
- 229960004452 methionine Drugs 0.000 description 8
- 150000002301 glucosamine derivatives Chemical class 0.000 description 7
- 235000018102 proteins Nutrition 0.000 description 7
- 102000004169 proteins and genes Human genes 0.000 description 7
- 108090000623 proteins and genes Proteins 0.000 description 7
- 230000002378 acidificating effect Effects 0.000 description 6
- 150000001875 compounds Chemical class 0.000 description 6
- JPLATTLXZFUKRQ-UHFFFAOYSA-N Agarobiose Natural products OCC1OC(OC2C(O)COC2C(O)C=O)C(O)C(O)C1O JPLATTLXZFUKRQ-UHFFFAOYSA-N 0.000 description 5
- 229920002683 Glycosaminoglycan Polymers 0.000 description 5
- 125000003277 amino group Chemical group 0.000 description 5
- 230000000052 comparative effect Effects 0.000 description 5
- 239000003814 drug Substances 0.000 description 5
- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 description 4
- MJQHZNBUODTQTK-WKGBVCLCSA-N (2s,3r,4s,5r,6r)-2-[[(1s,3s,4s,5s,8r)-3-[(2s,3r,4s,5s,6r)-2-[[(1s,3r,4s,5s,8r)-3,4-dihydroxy-2,6-dioxabicyclo[3.2.1]octan-8-yl]oxy]-3,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-4-hydroxy-2,6-dioxabicyclo[3.2.1]octan-8-yl]oxy]-6-(hydroxymethyl)oxane-3,4,5- Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@H]1[C@H]2OC[C@@H]1O[C@@H](O[C@@H]1[C@H]([C@H](O[C@H]3[C@H]4OC[C@@H]3O[C@@H](O)[C@H]4O)O[C@H](CO)[C@@H]1O)O)[C@H]2O MJQHZNBUODTQTK-WKGBVCLCSA-N 0.000 description 4
- 229920001817 Agar Polymers 0.000 description 4
- IAJILQKETJEXLJ-UHFFFAOYSA-N Galacturonsaeure Natural products O=CC(O)C(O)C(O)C(O)C(O)=O IAJILQKETJEXLJ-UHFFFAOYSA-N 0.000 description 4
- 239000008272 agar Substances 0.000 description 4
- 206010003246 arthritis Diseases 0.000 description 4
- VFLDPWHFBUODDF-FCXRPNKRSA-N curcumin Chemical compound C1=C(O)C(OC)=CC(\C=C\C(=O)CC(=O)\C=C\C=2C=C(OC)C(O)=CC=2)=C1 VFLDPWHFBUODDF-FCXRPNKRSA-N 0.000 description 4
- 229960002433 cysteine Drugs 0.000 description 4
- 229940079593 drug Drugs 0.000 description 4
- 239000000796 flavoring agent Substances 0.000 description 4
- 235000013355 food flavoring agent Nutrition 0.000 description 4
- 235000013376 functional food Nutrition 0.000 description 4
- 239000008187 granular material Substances 0.000 description 4
- 229920002674 hyaluronan Polymers 0.000 description 4
- 229960003160 hyaluronic acid Drugs 0.000 description 4
- 230000004054 inflammatory process Effects 0.000 description 4
- 239000000843 powder Substances 0.000 description 4
- 239000000243 solution Substances 0.000 description 4
- 235000000346 sugar Nutrition 0.000 description 4
- 208000024891 symptom Diseases 0.000 description 4
- AEMOLEFTQBMNLQ-AQKNRBDQSA-N D-glucopyranuronic acid Chemical compound OC1O[C@H](C(O)=O)[C@@H](O)[C@H](O)[C@H]1O AEMOLEFTQBMNLQ-AQKNRBDQSA-N 0.000 description 3
- QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 description 3
- 125000002777 acetyl group Chemical group [H]C([H])([H])C(*)=O 0.000 description 3
- 125000000217 alkyl group Chemical group 0.000 description 3
- 239000002775 capsule Substances 0.000 description 3
- 210000004027 cell Anatomy 0.000 description 3
- 238000013329 compounding Methods 0.000 description 3
- 235000015872 dietary supplement Nutrition 0.000 description 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 3
- 239000000839 emulsion Substances 0.000 description 3
- 235000013373 food additive Nutrition 0.000 description 3
- 239000002778 food additive Substances 0.000 description 3
- 229940097043 glucuronic acid Drugs 0.000 description 3
- 239000007902 hard capsule Substances 0.000 description 3
- 210000003041 ligament Anatomy 0.000 description 3
- 238000002156 mixing Methods 0.000 description 3
- 150000002482 oligosaccharides Chemical class 0.000 description 3
- 239000006187 pill Substances 0.000 description 3
- 206010039073 rheumatoid arthritis Diseases 0.000 description 3
- 239000007901 soft capsule Substances 0.000 description 3
- 238000005728 strengthening Methods 0.000 description 3
- 239000000725 suspension Substances 0.000 description 3
- 210000001519 tissue Anatomy 0.000 description 3
- YBJHBAHKTGYVGT-ZKWXMUAHSA-N (+)-Biotin Chemical compound N1C(=O)N[C@@H]2[C@H](CCCCC(=O)O)SC[C@@H]21 YBJHBAHKTGYVGT-ZKWXMUAHSA-N 0.000 description 2
- CBOJBBMQJBVCMW-BTVCFUMJSA-N (2r,3r,4s,5r)-2-amino-3,4,5,6-tetrahydroxyhexanal;hydrochloride Chemical compound Cl.O=C[C@H](N)[C@@H](O)[C@H](O)[C@H](O)CO CBOJBBMQJBVCMW-BTVCFUMJSA-N 0.000 description 2
- GHOKWGTUZJEAQD-ZETCQYMHSA-N (D)-(+)-Pantothenic acid Chemical compound OCC(C)(C)[C@@H](O)C(=O)NCCC(O)=O GHOKWGTUZJEAQD-ZETCQYMHSA-N 0.000 description 2
- GVJHHUAWPYXKBD-UHFFFAOYSA-N (±)-α-Tocopherol Chemical compound OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 description 2
- DCQFFOLNJVGHLW-UHFFFAOYSA-N 4'-Me ether-Punctatin+ Natural products O1C(O)C(O)C2OCC1C2O DCQFFOLNJVGHLW-UHFFFAOYSA-N 0.000 description 2
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 description 2
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 2
- 229920002567 Chondroitin Polymers 0.000 description 2
- 239000004375 Dextrin Substances 0.000 description 2
- 229920001353 Dextrin Polymers 0.000 description 2
- 241000196324 Embryophyta Species 0.000 description 2
- VZCYOOQTPOCHFL-OWOJBTEDSA-N Fumaric acid Chemical compound OC(=O)\C=C\C(O)=O VZCYOOQTPOCHFL-OWOJBTEDSA-N 0.000 description 2
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 description 2
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 description 2
- 206010024453 Ligament sprain Diseases 0.000 description 2
- FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 description 2
- 208000002193 Pain Diseases 0.000 description 2
- DLRVVLDZNNYCBX-UHFFFAOYSA-N Polydextrose Polymers OC1C(O)C(O)C(CO)OC1OCC1C(O)C(O)C(O)C(O)O1 DLRVVLDZNNYCBX-UHFFFAOYSA-N 0.000 description 2
- 241000124033 Salix Species 0.000 description 2
- QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 description 2
- WOXFJMBEAOAXKD-XLSKCSLXSA-N [(2R,3R,4R,5R)-6-acetyl-5-amino-3,4,6-trihydroxyoxan-2-yl]methyl hydrogen sulfate Chemical compound S(=O)(=O)(O)OC[C@@H]1[C@@H]([C@@H]([C@H](C(O)(O1)C(C)=O)N)O)O WOXFJMBEAOAXKD-XLSKCSLXSA-N 0.000 description 2
- RFNVIAWTEKUETG-XLSKCSLXSA-N [(2R,3R,4R,5R)-6-acetyl-5-amino-4,6-dihydroxy-2-(hydroxymethyl)oxan-3-yl] hydrogen sulfate Chemical compound S(=O)(=O)(O)O[C@@H]1[C@@H]([C@H](C(O)(O[C@@H]1CO)C(C)=O)N)O RFNVIAWTEKUETG-XLSKCSLXSA-N 0.000 description 2
- 239000002253 acid Substances 0.000 description 2
- 125000002252 acyl group Chemical group 0.000 description 2
- 230000032683 aging Effects 0.000 description 2
- AVJBPWGFOQAPRH-FWMKGIEWSA-N alpha-L-IdopA-(1->3)-beta-D-GalpNAc4S Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@H](OS(O)(=O)=O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O)[C@H](C(O)=O)O1 AVJBPWGFOQAPRH-FWMKGIEWSA-N 0.000 description 2
- 210000001188 articular cartilage Anatomy 0.000 description 2
- 239000011230 binding agent Substances 0.000 description 2
- 210000000988 bone and bone Anatomy 0.000 description 2
- 239000011575 calcium Substances 0.000 description 2
- 229910052791 calcium Inorganic materials 0.000 description 2
- 125000004432 carbon atom Chemical group C* 0.000 description 2
- 229910002091 carbon monoxide Inorganic materials 0.000 description 2
- 239000003795 chemical substances by application Substances 0.000 description 2
- DLGJWSVWTWEWBJ-HGGSSLSASA-N chondroitin Chemical compound CC(O)=N[C@@H]1[C@H](O)O[C@H](CO)[C@H](O)[C@@H]1OC1[C@H](O)[C@H](O)C=C(C(O)=O)O1 DLGJWSVWTWEWBJ-HGGSSLSASA-N 0.000 description 2
- KXKPYJOVDUMHGS-OSRGNVMNSA-N chondroitin sulfate Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](OS(O)(=O)=O)[C@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](C(O)=O)O1 KXKPYJOVDUMHGS-OSRGNVMNSA-N 0.000 description 2
- 239000003086 colorant Substances 0.000 description 2
- 238000007796 conventional method Methods 0.000 description 2
- 235000012754 curcumin Nutrition 0.000 description 2
- 239000004148 curcumin Substances 0.000 description 2
- 229940109262 curcumin Drugs 0.000 description 2
- 235000019425 dextrin Nutrition 0.000 description 2
- VFLDPWHFBUODDF-UHFFFAOYSA-N diferuloylmethane Natural products C1=C(O)C(OC)=CC(C=CC(=O)CC(=O)C=CC=2C=C(OC)C(O)=CC=2)=C1 VFLDPWHFBUODDF-UHFFFAOYSA-N 0.000 description 2
- 150000002016 disaccharides Chemical class 0.000 description 2
- 208000035475 disorder Diseases 0.000 description 2
- 239000002552 dosage form Substances 0.000 description 2
- 239000003995 emulsifying agent Substances 0.000 description 2
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 description 2
- 238000011156 evaluation Methods 0.000 description 2
- 238000002474 experimental method Methods 0.000 description 2
- OVBPIULPVIDEAO-LBPRGKRZSA-N folic acid Chemical compound C=1N=C2NC(N)=NC(=O)C2=NC=1CNC1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 OVBPIULPVIDEAO-LBPRGKRZSA-N 0.000 description 2
- 230000037406 food intake Effects 0.000 description 2
- 235000003599 food sweetener Nutrition 0.000 description 2
- 230000002496 gastric effect Effects 0.000 description 2
- 229940002508 ginger extract Drugs 0.000 description 2
- 235000020708 ginger extract Nutrition 0.000 description 2
- 229960001911 glucosamine hydrochloride Drugs 0.000 description 2
- 230000002757 inflammatory effect Effects 0.000 description 2
- 239000004615 ingredient Substances 0.000 description 2
- 239000000314 lubricant Substances 0.000 description 2
- 239000011777 magnesium Substances 0.000 description 2
- 229910052749 magnesium Inorganic materials 0.000 description 2
- 230000007721 medicinal effect Effects 0.000 description 2
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 2
- 229930014626 natural product Natural products 0.000 description 2
- 229940114496 olive leaf extract Drugs 0.000 description 2
- 201000008482 osteoarthritis Diseases 0.000 description 2
- 230000036407 pain Effects 0.000 description 2
- 239000000546 pharmaceutical excipient Substances 0.000 description 2
- 230000000144 pharmacologic effect Effects 0.000 description 2
- 238000002360 preparation method Methods 0.000 description 2
- 239000000047 product Substances 0.000 description 2
- LXNHXLLTXMVWPM-UHFFFAOYSA-N pyridoxine Chemical compound CC1=NC=C(CO)C(CO)=C1O LXNHXLLTXMVWPM-UHFFFAOYSA-N 0.000 description 2
- 239000002994 raw material Substances 0.000 description 2
- 230000002787 reinforcement Effects 0.000 description 2
- 238000011160 research Methods 0.000 description 2
- 239000002904 solvent Substances 0.000 description 2
- 235000015096 spirit Nutrition 0.000 description 2
- 239000006228 supernatant Substances 0.000 description 2
- 239000000375 suspending agent Substances 0.000 description 2
- 239000003765 sweetening agent Substances 0.000 description 2
- 210000002437 synoviocyte Anatomy 0.000 description 2
- 239000006188 syrup Substances 0.000 description 2
- 235000020357 syrup Nutrition 0.000 description 2
- 150000004044 tetrasaccharides Chemical class 0.000 description 2
- 229940088594 vitamin Drugs 0.000 description 2
- 229930003231 vitamin Natural products 0.000 description 2
- 235000013343 vitamin Nutrition 0.000 description 2
- 239000011782 vitamin Substances 0.000 description 2
- 239000000080 wetting agent Substances 0.000 description 2
- PFTAWBLQPZVEMU-DZGCQCFKSA-N (+)-catechin Chemical compound C1([C@H]2OC3=CC(O)=CC(O)=C3C[C@@H]2O)=CC=C(O)C(O)=C1 PFTAWBLQPZVEMU-DZGCQCFKSA-N 0.000 description 1
- DCQFFOLNJVGHLW-YIDFTEPTSA-N (1r,4r,5s,8s)-2,6-dioxabicyclo[3.2.1]octane-3,4,8-triol Chemical compound O[C@@H]1[C@]2([H])OC[C@@]1([H])OC(O)[C@@H]2O DCQFFOLNJVGHLW-YIDFTEPTSA-N 0.000 description 1
- PURMPUDWXOWORS-QTBDOELSSA-N (2s,3s,4s,5r)-2,3,4-trihydroxy-6-oxo-5-sulfooxyhexanoic acid Chemical compound OC(=O)[C@@H](O)[C@@H](O)[C@H](O)[C@@H](OS(O)(=O)=O)C=O PURMPUDWXOWORS-QTBDOELSSA-N 0.000 description 1
- MTDHILKWIRSIHB-UHFFFAOYSA-N (5-azaniumyl-3,4,6-trihydroxyoxan-2-yl)methyl sulfate Chemical compound NC1C(O)OC(COS(O)(=O)=O)C(O)C1O MTDHILKWIRSIHB-UHFFFAOYSA-N 0.000 description 1
- FPIPGXGPPPQFEQ-UHFFFAOYSA-N 13-cis retinol Natural products OCC=C(C)C=CC=C(C)C=CC1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-UHFFFAOYSA-N 0.000 description 1
- LBLYYCQCTBFVLH-UHFFFAOYSA-M 2-methylbenzenesulfonate Chemical compound CC1=CC=CC=C1S([O-])(=O)=O LBLYYCQCTBFVLH-UHFFFAOYSA-M 0.000 description 1
- IBZYPBGPOGJMBF-UHFFFAOYSA-N 3,6 anhydrogalactose Natural products CCC=CCC1C(CC(=O)NC(C(C)CC)C(O)=O)CCC1=O IBZYPBGPOGJMBF-UHFFFAOYSA-N 0.000 description 1
- WZYRMLAWNVOIEX-BGPJRJDNSA-N 3,6-anhydro-D-galactose Chemical compound O=C[C@H](O)[C@H]1OC[C@@H](O)[C@@H]1O WZYRMLAWNVOIEX-BGPJRJDNSA-N 0.000 description 1
- FNEHAOQZWPHONV-UHFFFAOYSA-N 9h-carbazole;sulfuric acid Chemical compound OS(O)(=O)=O.C1=CC=C2C3=CC=CC=C3NC2=C1 FNEHAOQZWPHONV-UHFFFAOYSA-N 0.000 description 1
- QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 description 1
- 241000251468 Actinopterygii Species 0.000 description 1
- 241000222518 Agaricus Species 0.000 description 1
- 235000001674 Agaricus brunnescens Nutrition 0.000 description 1
- 241000583531 Alpinia purpurata Species 0.000 description 1
- 239000004475 Arginine Substances 0.000 description 1
- 208000006820 Arthralgia Diseases 0.000 description 1
- 108010011485 Aspartame Proteins 0.000 description 1
- 241000283690 Bos taurus Species 0.000 description 1
- FERIUCNNQQJTOY-UHFFFAOYSA-M Butyrate Chemical compound CCCC([O-])=O FERIUCNNQQJTOY-UHFFFAOYSA-M 0.000 description 1
- FERIUCNNQQJTOY-UHFFFAOYSA-N Butyric acid Natural products CCCC(O)=O FERIUCNNQQJTOY-UHFFFAOYSA-N 0.000 description 1
- 244000003240 Caesalpinia gilliesii Species 0.000 description 1
- 235000014161 Caesalpinia gilliesii Nutrition 0.000 description 1
- GHOKWGTUZJEAQD-UHFFFAOYSA-N Chick antidermatitis factor Natural products OCC(C)(C)C(O)C(=O)NCCC(O)=O GHOKWGTUZJEAQD-UHFFFAOYSA-N 0.000 description 1
- 241000251730 Chondrichthyes Species 0.000 description 1
- KRKNYBCHXYNGOX-UHFFFAOYSA-K Citrate Chemical compound [O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O KRKNYBCHXYNGOX-UHFFFAOYSA-K 0.000 description 1
- 244000163122 Curcuma domestica Species 0.000 description 1
- 235000003392 Curcuma domestica Nutrition 0.000 description 1
- YPWSLBHSMIKTPR-UHFFFAOYSA-N Cystathionine Natural products OC(=O)C(N)CCSSCC(N)C(O)=O YPWSLBHSMIKTPR-UHFFFAOYSA-N 0.000 description 1
- 102000004127 Cytokines Human genes 0.000 description 1
- 108090000695 Cytokines Proteins 0.000 description 1
- AUNGANRZJHBGPY-UHFFFAOYSA-N D-Lyxoflavin Natural products OCC(O)C(O)C(O)CN1C=2C=C(C)C(C)=CC=2N=C2C1=NC(=O)NC2=O AUNGANRZJHBGPY-UHFFFAOYSA-N 0.000 description 1
- ILRYLPWNYFXEMH-UHFFFAOYSA-N D-cystathionine Natural products OC(=O)C(N)CCSCC(N)C(O)=O ILRYLPWNYFXEMH-UHFFFAOYSA-N 0.000 description 1
- ZZZCUOFIHGPKAK-UHFFFAOYSA-N D-erythro-ascorbic acid Natural products OCC1OC(=O)C(O)=C1O ZZZCUOFIHGPKAK-UHFFFAOYSA-N 0.000 description 1
- 229920000045 Dermatan sulfate Polymers 0.000 description 1
- FEWJPZIEWOKRBE-JCYAYHJZSA-N Dextrotartaric acid Chemical compound OC(=O)[C@H](O)[C@@H](O)C(O)=O FEWJPZIEWOKRBE-JCYAYHJZSA-N 0.000 description 1
- 102000010834 Extracellular Matrix Proteins Human genes 0.000 description 1
- 108010037362 Extracellular Matrix Proteins Proteins 0.000 description 1
- 241000272185 Falco Species 0.000 description 1
- 239000004606 Fillers/Extenders Substances 0.000 description 1
- 239000005715 Fructose Substances 0.000 description 1
- 229930091371 Fructose Natural products 0.000 description 1
- RFSUNEUAIZKAJO-ARQDHWQXSA-N Fructose Chemical compound OC[C@H]1O[C@](O)(CO)[C@@H](O)[C@@H]1O RFSUNEUAIZKAJO-ARQDHWQXSA-N 0.000 description 1
- FZHXIRIBWMQPQF-UHFFFAOYSA-N Glc-NH2 Natural products O=CC(N)C(O)C(O)C(O)CO FZHXIRIBWMQPQF-UHFFFAOYSA-N 0.000 description 1
- 239000004471 Glycine Substances 0.000 description 1
- 102000003886 Glycoproteins Human genes 0.000 description 1
- 108090000288 Glycoproteins Proteins 0.000 description 1
- 240000004670 Glycyrrhiza echinata Species 0.000 description 1
- 235000001453 Glycyrrhiza echinata Nutrition 0.000 description 1
- 235000006200 Glycyrrhiza glabra Nutrition 0.000 description 1
- 235000017382 Glycyrrhiza lepidota Nutrition 0.000 description 1
- HTTJABKRGRZYRN-UHFFFAOYSA-N Heparin Chemical compound OC1C(NC(=O)C)C(O)OC(COS(O)(=O)=O)C1OC1C(OS(O)(=O)=O)C(O)C(OC2C(C(OS(O)(=O)=O)C(OC3C(C(O)C(O)C(O3)C(O)=O)OS(O)(=O)=O)C(CO)O2)NS(O)(=O)=O)C(C(O)=O)O1 HTTJABKRGRZYRN-UHFFFAOYSA-N 0.000 description 1
- CPELXLSAUQHCOX-UHFFFAOYSA-N Hydrogen bromide Chemical class Br CPELXLSAUQHCOX-UHFFFAOYSA-N 0.000 description 1
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 1
- FFEARJCKVFRZRR-UHFFFAOYSA-N L-Methionine Natural products CSCCC(N)C(O)=O FFEARJCKVFRZRR-UHFFFAOYSA-N 0.000 description 1
- ONIBWKKTOPOVIA-BYPYZUCNSA-N L-Proline Chemical compound OC(=O)[C@@H]1CCCN1 ONIBWKKTOPOVIA-BYPYZUCNSA-N 0.000 description 1
- QNAYBMKLOCPYGJ-REOHCLBHSA-N L-alanine Chemical compound C[C@H](N)C(O)=O QNAYBMKLOCPYGJ-REOHCLBHSA-N 0.000 description 1
- ODKSFYDXXFIFQN-BYPYZUCNSA-P L-argininium(2+) Chemical compound NC(=[NH2+])NCCC[C@H]([NH3+])C(O)=O ODKSFYDXXFIFQN-BYPYZUCNSA-P 0.000 description 1
- ILRYLPWNYFXEMH-WHFBIAKZSA-N L-cystathionine Chemical compound [O-]C(=O)[C@@H]([NH3+])CCSC[C@H]([NH3+])C([O-])=O ILRYLPWNYFXEMH-WHFBIAKZSA-N 0.000 description 1
- 239000004201 L-cysteine Substances 0.000 description 1
- 235000013878 L-cysteine Nutrition 0.000 description 1
- LEVWYRKDKASIDU-IMJSIDKUSA-N L-cystine Chemical compound [O-]C(=O)[C@@H]([NH3+])CSSC[C@H]([NH3+])C([O-])=O LEVWYRKDKASIDU-IMJSIDKUSA-N 0.000 description 1
- AEMOLEFTQBMNLQ-HNFCZKTMSA-N L-idopyranuronic acid Chemical compound OC1O[C@@H](C(O)=O)[C@@H](O)[C@H](O)[C@H]1O AEMOLEFTQBMNLQ-HNFCZKTMSA-N 0.000 description 1
- KDXKERNSBIXSRK-YFKPBYRVSA-N L-lysine Chemical compound NCCCC[C@H](N)C(O)=O KDXKERNSBIXSRK-YFKPBYRVSA-N 0.000 description 1
- 229930195722 L-methionine Natural products 0.000 description 1
- JVTAAEKCZFNVCJ-UHFFFAOYSA-M Lactate Chemical compound CC(O)C([O-])=O JVTAAEKCZFNVCJ-UHFFFAOYSA-M 0.000 description 1
- 240000000599 Lentinula edodes Species 0.000 description 1
- 235000001715 Lentinula edodes Nutrition 0.000 description 1
- UPYKUZBSLRQECL-UKMVMLAPSA-N Lycopene Natural products CC(=C/C=C/C=C(C)/C=C/C=C(C)/C=C/C1C(=C)CCCC1(C)C)C=CC=C(/C)C=CC2C(=C)CCCC2(C)C UPYKUZBSLRQECL-UKMVMLAPSA-N 0.000 description 1
- JEVVKJMRZMXFBT-XWDZUXABSA-N Lycophyll Natural products OC/C(=C/CC/C(=C\C=C\C(=C/C=C/C(=C\C=C\C=C(/C=C/C=C(\C=C\C=C(/CC/C=C(/CO)\C)\C)/C)\C)/C)\C)/C)/C JEVVKJMRZMXFBT-XWDZUXABSA-N 0.000 description 1
- KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 description 1
- 239000004472 Lysine Substances 0.000 description 1
- OFOBLEOULBTSOW-UHFFFAOYSA-L Malonate Chemical compound [O-]C(=O)CC([O-])=O OFOBLEOULBTSOW-UHFFFAOYSA-L 0.000 description 1
- 241000124008 Mammalia Species 0.000 description 1
- 241001272720 Medialuna californiensis Species 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- AFVFQIVMOAPDHO-UHFFFAOYSA-N Methanesulfonic acid Chemical compound CS(O)(=O)=O AFVFQIVMOAPDHO-UHFFFAOYSA-N 0.000 description 1
- 208000010428 Muscle Weakness Diseases 0.000 description 1
- 206010028372 Muscular weakness Diseases 0.000 description 1
- OVBPIULPVIDEAO-UHFFFAOYSA-N N-Pteroyl-L-glutaminsaeure Natural products C=1N=C2NC(N)=NC(=O)C2=NC=1CNC1=CC=C(C(=O)NC(CCC(O)=O)C(O)=O)C=C1 OVBPIULPVIDEAO-UHFFFAOYSA-N 0.000 description 1
- 244000183278 Nephelium litchi Species 0.000 description 1
- PVNIIMVLHYAWGP-UHFFFAOYSA-N Niacin Chemical compound OC(=O)C1=CC=CN=C1 PVNIIMVLHYAWGP-UHFFFAOYSA-N 0.000 description 1
- 229910019142 PO4 Inorganic materials 0.000 description 1
- 235000006484 Paeonia officinalis Nutrition 0.000 description 1
- 244000170916 Paeonia officinalis Species 0.000 description 1
- 229920001100 Polydextrose Polymers 0.000 description 1
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 description 1
- 244000082490 Proboscidea louisianica Species 0.000 description 1
- 235000015926 Proboscidea louisianica ssp. fragrans Nutrition 0.000 description 1
- 235000015925 Proboscidea louisianica subsp. louisianica Nutrition 0.000 description 1
- 235000019096 Proboscidea parviflora Nutrition 0.000 description 1
- ONIBWKKTOPOVIA-UHFFFAOYSA-N Proline Natural products OC(=O)C1CCCN1 ONIBWKKTOPOVIA-UHFFFAOYSA-N 0.000 description 1
- 241000241413 Propolis Species 0.000 description 1
- AUNGANRZJHBGPY-SCRDCRAPSA-N Riboflavin Chemical compound OC[C@@H](O)[C@@H](O)[C@@H](O)CN1C=2C=C(C)C(C)=CC=2N=C2C1=NC(=O)NC2=O AUNGANRZJHBGPY-SCRDCRAPSA-N 0.000 description 1
- BUGBHKTXTAQXES-UHFFFAOYSA-N Selenium Chemical compound [Se] BUGBHKTXTAQXES-UHFFFAOYSA-N 0.000 description 1
- 229930006000 Sucrose Natural products 0.000 description 1
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 1
- DTQVDTLACAAQTR-UHFFFAOYSA-M Trifluoroacetate Chemical compound [O-]C(=O)C(F)(F)F DTQVDTLACAAQTR-UHFFFAOYSA-M 0.000 description 1
- FPIPGXGPPPQFEQ-BOOMUCAASA-N Vitamin A Natural products OC/C=C(/C)\C=C\C=C(\C)/C=C/C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-BOOMUCAASA-N 0.000 description 1
- 229930003451 Vitamin B1 Natural products 0.000 description 1
- 229930003779 Vitamin B12 Natural products 0.000 description 1
- 229930003471 Vitamin B2 Natural products 0.000 description 1
- 229930003268 Vitamin C Natural products 0.000 description 1
- 229930003316 Vitamin D Natural products 0.000 description 1
- QYSXJUFSXHHAJI-XFEUOLMDSA-N Vitamin D3 Natural products C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)CCCC(C)C)=C/C=C1\C[C@@H](O)CCC1=C QYSXJUFSXHHAJI-XFEUOLMDSA-N 0.000 description 1
- 229930003427 Vitamin E Natural products 0.000 description 1
- 229930003448 Vitamin K Natural products 0.000 description 1
- HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 description 1
- SGYGTSHMASTHET-XLSKCSLXSA-N [(2R,3R,4R,5R)-6-acetyl-5-amino-4,6-dihydroxy-2-(sulfooxymethyl)oxan-3-yl] hydrogen sulfate Chemical compound S(=O)(=O)(O)O[C@@H]1[C@@H]([C@H](C(O)(O[C@@H]1COS(=O)(=O)O)C(C)=O)N)O SGYGTSHMASTHET-XLSKCSLXSA-N 0.000 description 1
- 238000011481 absorbance measurement Methods 0.000 description 1
- 239000004480 active ingredient Substances 0.000 description 1
- 235000004279 alanine Nutrition 0.000 description 1
- 229910052783 alkali metal Inorganic materials 0.000 description 1
- 150000001340 alkali metals Chemical class 0.000 description 1
- 229910052784 alkaline earth metal Inorganic materials 0.000 description 1
- 150000001342 alkaline earth metals Chemical class 0.000 description 1
- FPIPGXGPPPQFEQ-OVSJKPMPSA-N all-trans-retinol Chemical compound OC\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-OVSJKPMPSA-N 0.000 description 1
- WQZGKKKJIJFFOK-PHYPRBDBSA-N alpha-D-galactose Chemical compound OC[C@H]1O[C@H](O)[C@H](O)[C@@H](O)[C@H]1O WQZGKKKJIJFFOK-PHYPRBDBSA-N 0.000 description 1
- 229910052782 aluminium Inorganic materials 0.000 description 1
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 description 1
- 150000003863 ammonium salts Chemical class 0.000 description 1
- 230000036592 analgesia Effects 0.000 description 1
- 230000003042 antagnostic effect Effects 0.000 description 1
- 230000008485 antagonism Effects 0.000 description 1
- 235000010208 anthocyanin Nutrition 0.000 description 1
- 239000004410 anthocyanin Substances 0.000 description 1
- 229930002877 anthocyanin Natural products 0.000 description 1
- 150000004636 anthocyanins Chemical class 0.000 description 1
- 229940121363 anti-inflammatory agent Drugs 0.000 description 1
- 239000002260 anti-inflammatory agent Substances 0.000 description 1
- 239000003963 antioxidant agent Substances 0.000 description 1
- 230000003078 antioxidant effect Effects 0.000 description 1
- 235000006708 antioxidants Nutrition 0.000 description 1
- ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 description 1
- 239000000605 aspartame Substances 0.000 description 1
- IAOZJIPTCAWIRG-QWRGUYRKSA-N aspartame Chemical compound OC(=O)C[C@H](N)C(=O)N[C@H](C(=O)OC)CC1=CC=CC=C1 IAOZJIPTCAWIRG-QWRGUYRKSA-N 0.000 description 1
- 235000010357 aspartame Nutrition 0.000 description 1
- 229960003438 aspartame Drugs 0.000 description 1
- 230000002238 attenuated effect Effects 0.000 description 1
- 239000012752 auxiliary agent Substances 0.000 description 1
- 230000008901 benefit Effects 0.000 description 1
- 125000003236 benzoyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C(*)=O 0.000 description 1
- 235000013361 beverage Nutrition 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 235000020958 biotin Nutrition 0.000 description 1
- 239000011616 biotin Substances 0.000 description 1
- 229960002685 biotin Drugs 0.000 description 1
- 230000017531 blood circulation Effects 0.000 description 1
- 230000037237 body shape Effects 0.000 description 1
- 239000006172 buffering agent Substances 0.000 description 1
- 125000000484 butyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- 150000007942 carboxylates Chemical class 0.000 description 1
- 210000000845 cartilage Anatomy 0.000 description 1
- 235000005487 catechin Nutrition 0.000 description 1
- ADRVNXBAWSRFAJ-UHFFFAOYSA-N catechin Natural products OC1Cc2cc(O)cc(O)c2OC1c3ccc(O)c(O)c3 ADRVNXBAWSRFAJ-UHFFFAOYSA-N 0.000 description 1
- 235000011472 cat’s claw Nutrition 0.000 description 1
- 239000004568 cement Substances 0.000 description 1
- 229940106189 ceramide Drugs 0.000 description 1
- 150000001783 ceramides Chemical class 0.000 description 1
- 229940094517 chondroitin 4-sulfate Drugs 0.000 description 1
- 229950001002 cianidanol Drugs 0.000 description 1
- WZYRMLAWNVOIEX-UHFFFAOYSA-N cinnamtannin B-2 Natural products O=CC(O)C1OCC(O)C1O WZYRMLAWNVOIEX-UHFFFAOYSA-N 0.000 description 1
- 239000011248 coating agent Substances 0.000 description 1
- AGVAZMGAQJOSFJ-WZHZPDAFSA-M cobalt(2+);[(2r,3s,4r,5s)-5-(5,6-dimethylbenzimidazol-1-yl)-4-hydroxy-2-(hydroxymethyl)oxolan-3-yl] [(2r)-1-[3-[(1r,2r,3r,4z,7s,9z,12s,13s,14z,17s,18s,19r)-2,13,18-tris(2-amino-2-oxoethyl)-7,12,17-tris(3-amino-3-oxopropyl)-3,5,8,8,13,15,18,19-octamethyl-2 Chemical compound [Co+2].N#[C-].[N-]([C@@H]1[C@H](CC(N)=O)[C@@]2(C)CCC(=O)NC[C@@H](C)OP(O)(=O)O[C@H]3[C@H]([C@H](O[C@@H]3CO)N3C4=CC(C)=C(C)C=C4N=C3)O)\C2=C(C)/C([C@H](C\2(C)C)CCC(N)=O)=N/C/2=C\C([C@H]([C@@]/2(CC(N)=O)C)CCC(N)=O)=N\C\2=C(C)/C2=N[C@]1(C)[C@@](C)(CC(N)=O)[C@@H]2CCC(N)=O AGVAZMGAQJOSFJ-WZHZPDAFSA-M 0.000 description 1
- 229920002770 condensed tannin Polymers 0.000 description 1
- 239000000470 constituent Substances 0.000 description 1
- 239000012043 crude product Substances 0.000 description 1
- 235000003373 curcuma longa Nutrition 0.000 description 1
- 229960003067 cystine Drugs 0.000 description 1
- 229940051593 dermatan sulfate Drugs 0.000 description 1
- 235000013325 dietary fiber Nutrition 0.000 description 1
- 239000003085 diluting agent Substances 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 239000007884 disintegrant Substances 0.000 description 1
- 239000002270 dispersing agent Substances 0.000 description 1
- 235000019126 equol Nutrition 0.000 description 1
- ADFCQWZHKCXPAJ-GFCCVEGCSA-N equol Chemical compound C1=CC(O)=CC=C1[C@@H]1CC2=CC=C(O)C=C2OC1 ADFCQWZHKCXPAJ-GFCCVEGCSA-N 0.000 description 1
- 210000002744 extracellular matrix Anatomy 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 229960000304 folic acid Drugs 0.000 description 1
- 235000019152 folic acid Nutrition 0.000 description 1
- 239000011724 folic acid Substances 0.000 description 1
- 238000005194 fractionation Methods 0.000 description 1
- 229960002737 fructose Drugs 0.000 description 1
- 239000001530 fumaric acid Substances 0.000 description 1
- 229930182830 galactose Natural products 0.000 description 1
- WIGCFUFOHFEKBI-UHFFFAOYSA-N gamma-tocopherol Natural products CC(C)CCCC(C)CCCC(C)CCCC1CCC2C(C)C(O)C(C)C(C)C2O1 WIGCFUFOHFEKBI-UHFFFAOYSA-N 0.000 description 1
- 238000005227 gel permeation chromatography Methods 0.000 description 1
- 229960002849 glucosamine sulfate Drugs 0.000 description 1
- 150000002337 glycosamines Chemical class 0.000 description 1
- 238000009499 grossing Methods 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- 235000013402 health food Nutrition 0.000 description 1
- 229920000669 heparin Polymers 0.000 description 1
- 229960002897 heparin Drugs 0.000 description 1
- IPCSVZSSVZVIGE-UHFFFAOYSA-M hexadecanoate Chemical compound CCCCCCCCCCCCCCCC([O-])=O IPCSVZSSVZVIGE-UHFFFAOYSA-M 0.000 description 1
- 235000012907 honey Nutrition 0.000 description 1
- 150000003840 hydrochlorides Chemical class 0.000 description 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 1
- XLSMFKSTNGKWQX-UHFFFAOYSA-N hydroxyacetone Chemical compound CC(=O)CO XLSMFKSTNGKWQX-UHFFFAOYSA-N 0.000 description 1
- ADFCQWZHKCXPAJ-UHFFFAOYSA-N indofine Natural products C1=CC(O)=CC=C1C1CC2=CC=C(O)C=C2OC1 ADFCQWZHKCXPAJ-UHFFFAOYSA-N 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- 150000007529 inorganic bases Chemical class 0.000 description 1
- 229910052500 inorganic mineral Inorganic materials 0.000 description 1
- 229910052742 iron Inorganic materials 0.000 description 1
- 125000000959 isobutyl group Chemical group [H]C([H])([H])C([H])(C([H])([H])[H])C([H])([H])* 0.000 description 1
- CJWQYWQDLBZGPD-UHFFFAOYSA-N isoflavone Natural products C1=C(OC)C(OC)=CC(OC)=C1C1=COC2=C(C=CC(C)(C)O3)C3=C(OC)C=C2C1=O CJWQYWQDLBZGPD-UHFFFAOYSA-N 0.000 description 1
- 150000002515 isoflavone derivatives Chemical class 0.000 description 1
- 235000008696 isoflavones Nutrition 0.000 description 1
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 description 1
- 235000015110 jellies Nutrition 0.000 description 1
- 210000003127 knee Anatomy 0.000 description 1
- 229940010454 licorice Drugs 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 235000012661 lycopene Nutrition 0.000 description 1
- 229960004999 lycopene Drugs 0.000 description 1
- 239000001751 lycopene Substances 0.000 description 1
- OAIJSZIZWZSQBC-GYZMGTAESA-N lycopene Chemical compound CC(C)=CCC\C(C)=C\C=C\C(\C)=C\C=C\C(\C)=C\C=C\C=C(/C)\C=C\C=C(/C)\C=C\C=C(/C)CCC=C(C)C OAIJSZIZWZSQBC-GYZMGTAESA-N 0.000 description 1
- 150000002688 maleic acid derivatives Chemical class 0.000 description 1
- 239000000845 maltitol Substances 0.000 description 1
- 235000010449 maltitol Nutrition 0.000 description 1
- VQHSOMBJVWLPSR-WUJBLJFYSA-N maltitol Chemical compound OC[C@H](O)[C@@H](O)[C@@H]([C@H](O)CO)O[C@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O VQHSOMBJVWLPSR-WUJBLJFYSA-N 0.000 description 1
- 229940035436 maltitol Drugs 0.000 description 1
- 239000008204 material by function Substances 0.000 description 1
- 229910052751 metal Inorganic materials 0.000 description 1
- 239000002184 metal Substances 0.000 description 1
- 150000002739 metals Chemical class 0.000 description 1
- 229940016409 methylsulfonylmethane Drugs 0.000 description 1
- 239000011707 mineral Substances 0.000 description 1
- 210000003205 muscle Anatomy 0.000 description 1
- 235000001968 nicotinic acid Nutrition 0.000 description 1
- 229960003512 nicotinic acid Drugs 0.000 description 1
- 239000011664 nicotinic acid Substances 0.000 description 1
- 150000002823 nitrates Chemical class 0.000 description 1
- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 description 1
- 239000006186 oral dosage form Substances 0.000 description 1
- 229940126701 oral medication Drugs 0.000 description 1
- 150000007530 organic bases Chemical class 0.000 description 1
- 229940055726 pantothenic acid Drugs 0.000 description 1
- 235000019161 pantothenic acid Nutrition 0.000 description 1
- 239000011713 pantothenic acid Substances 0.000 description 1
- 239000000825 pharmaceutical preparation Substances 0.000 description 1
- 229940127557 pharmaceutical product Drugs 0.000 description 1
- 235000021317 phosphate Nutrition 0.000 description 1
- 150000003013 phosphoric acid derivatives Chemical class 0.000 description 1
- SHUZOJHMOBOZST-UHFFFAOYSA-N phylloquinone Natural products CC(C)CCCCC(C)CCC(C)CCCC(=CCC1=C(C)C(=O)c2ccccc2C1=O)C SHUZOJHMOBOZST-UHFFFAOYSA-N 0.000 description 1
- 239000001259 polydextrose Substances 0.000 description 1
- 235000013856 polydextrose Nutrition 0.000 description 1
- 229940035035 polydextrose Drugs 0.000 description 1
- 229920001184 polypeptide Polymers 0.000 description 1
- 150000008442 polyphenolic compounds Chemical class 0.000 description 1
- 235000013824 polyphenols Nutrition 0.000 description 1
- 239000011591 potassium Substances 0.000 description 1
- 229910052700 potassium Inorganic materials 0.000 description 1
- 239000003755 preservative agent Substances 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 108090000765 processed proteins & peptides Proteins 0.000 description 1
- 102000004196 processed proteins & peptides Human genes 0.000 description 1
- 150000005599 propionic acid derivatives Chemical class 0.000 description 1
- 229940069949 propolis Drugs 0.000 description 1
- 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- 238000000746 purification Methods 0.000 description 1
- RADKZDMFGJYCBB-UHFFFAOYSA-N pyridoxal hydrochloride Natural products CC1=NC=C(CO)C(C=O)=C1O RADKZDMFGJYCBB-UHFFFAOYSA-N 0.000 description 1
- 229960002477 riboflavin Drugs 0.000 description 1
- 229940109850 royal jelly Drugs 0.000 description 1
- 125000002914 sec-butyl group Chemical group [H]C([H])([H])C([H])([H])C([H])(*)C([H])([H])[H] 0.000 description 1
- 229910052711 selenium Inorganic materials 0.000 description 1
- 239000011669 selenium Substances 0.000 description 1
- UQDJGEHQDNVPGU-UHFFFAOYSA-N serine phosphoethanolamine Chemical compound [NH3+]CCOP([O-])(=O)OCC([NH3+])C([O-])=O UQDJGEHQDNVPGU-UHFFFAOYSA-N 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 239000011973 solid acid Substances 0.000 description 1
- 239000003381 stabilizer Substances 0.000 description 1
- 230000000638 stimulation Effects 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- KDYFGRWQOYBRFD-UHFFFAOYSA-L succinate(2-) Chemical compound [O-]C(=O)CCC([O-])=O KDYFGRWQOYBRFD-UHFFFAOYSA-L 0.000 description 1
- 239000005720 sucrose Substances 0.000 description 1
- 229960004793 sucrose Drugs 0.000 description 1
- 150000008163 sugars Chemical class 0.000 description 1
- 150000003871 sulfonates Chemical class 0.000 description 1
- HHVIBTZHLRERCL-UHFFFAOYSA-N sulfonyldimethane Chemical compound CS(C)(=O)=O HHVIBTZHLRERCL-UHFFFAOYSA-N 0.000 description 1
- 150000003467 sulfuric acid derivatives Chemical class 0.000 description 1
- 239000013589 supplement Substances 0.000 description 1
- 230000002459 sustained effect Effects 0.000 description 1
- 238000013268 sustained release Methods 0.000 description 1
- 239000012730 sustained-release form Substances 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
- 229940095064 tartrate Drugs 0.000 description 1
- 210000002435 tendon Anatomy 0.000 description 1
- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 229960003495 thiamine Drugs 0.000 description 1
- DPJRMOMPQZCRJU-UHFFFAOYSA-M thiamine hydrochloride Chemical compound Cl.[Cl-].CC1=C(CCO)SC=[N+]1CC1=CN=C(C)N=C1N DPJRMOMPQZCRJU-UHFFFAOYSA-M 0.000 description 1
- 239000002562 thickening agent Substances 0.000 description 1
- 125000002088 tosyl group Chemical group [H]C1=C([H])C(=C([H])C([H])=C1C([H])([H])[H])S(*)(=O)=O 0.000 description 1
- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 description 1
- ZCIHMQAPACOQHT-ZGMPDRQDSA-N trans-isorenieratene Natural products CC(=C/C=C/C=C(C)/C=C/C=C(C)/C=C/c1c(C)ccc(C)c1C)C=CC=C(/C)C=Cc2c(C)ccc(C)c2C ZCIHMQAPACOQHT-ZGMPDRQDSA-N 0.000 description 1
- 235000013976 turmeric Nutrition 0.000 description 1
- 235000019155 vitamin A Nutrition 0.000 description 1
- 239000011719 vitamin A Substances 0.000 description 1
- 235000010374 vitamin B1 Nutrition 0.000 description 1
- 239000011691 vitamin B1 Substances 0.000 description 1
- 235000019163 vitamin B12 Nutrition 0.000 description 1
- 239000011715 vitamin B12 Substances 0.000 description 1
- 235000019164 vitamin B2 Nutrition 0.000 description 1
- 239000011716 vitamin B2 Substances 0.000 description 1
- 235000019158 vitamin B6 Nutrition 0.000 description 1
- 239000011726 vitamin B6 Substances 0.000 description 1
- 235000019154 vitamin C Nutrition 0.000 description 1
- 239000011718 vitamin C Substances 0.000 description 1
- 235000019166 vitamin D Nutrition 0.000 description 1
- 239000011710 vitamin D Substances 0.000 description 1
- 150000003710 vitamin D derivatives Chemical class 0.000 description 1
- 235000019165 vitamin E Nutrition 0.000 description 1
- 239000011709 vitamin E Substances 0.000 description 1
- 229940046009 vitamin E Drugs 0.000 description 1
- 235000019168 vitamin K Nutrition 0.000 description 1
- 239000011712 vitamin K Substances 0.000 description 1
- 150000003721 vitamin K derivatives Chemical class 0.000 description 1
- 229940045997 vitamin a Drugs 0.000 description 1
- 229940011671 vitamin b6 Drugs 0.000 description 1
- 229940046008 vitamin d Drugs 0.000 description 1
- 150000003722 vitamin derivatives Chemical class 0.000 description 1
- 229940046010 vitamin k Drugs 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
- 239000011701 zinc Substances 0.000 description 1
- 229910052725 zinc Inorganic materials 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
- A61K31/198—Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7008—Compounds having an amino group directly attached to a carbon atom of the saccharide radical, e.g. D-galactosamine, ranimustine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/702—Oligosaccharides, i.e. having three to five saccharide radicals attached to each other by glycosidic linkages
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Description
本発明はグルコサミン化合物を含有する経口組成物に関する。特に、本発明は、グルコサミン化合物が有する抗炎症作用が一層増強されてなるグルコサミン化合物含有経口組成物(以下、「抗炎症作用強化グルコサミン化合物含有経口組成物」ともいう)に関する。また、本発明は当該抗炎症作用強化グルコサミン化合物含有経口組成物の製造方法に関する。 The present invention relates to an oral composition containing a glucosamine compound. In particular, the present invention relates to a glucosamine compound-containing oral composition (hereinafter also referred to as “anti-inflammatory action-enhanced glucosamine compound-containing oral composition”) in which the anti-inflammatory action of the glucosamine compound is further enhanced. Moreover, this invention relates to the manufacturing method of the said anti-inflammatory action reinforcement | strengthening glucosamine compound containing oral composition.
関節は骨と骨の連結部位であり、膝、肘、肩及び腰などを含む体中のいたるところに存在する。関節を隔てた骨同士は関節軟骨を介在して接し、筋肉や靭帯によって構成されている。関節は動作時に屈曲伸展を繰り返すので、そこにかかる負担は非常に大きなものである。ゆえに、経年(加齢)や運動疲労等により、関節軟骨の磨り減り、筋肉の脆弱化、血行障害などを生じることとなり、種々痛みを感じるようになる。これが広義に関節痛と呼ばれる症状である。 A joint is a bone-to-bone connection site and exists throughout the body including the knees, elbows, shoulders, and hips. The bones separated from each other are in contact with each other through articular cartilage, and are composed of muscles and ligaments. Since the joint repeatedly bends and stretches when it moves, the burden on the joint is very large. Therefore, due to aging (aging), exercise fatigue, etc., articular cartilage is worn down, muscle weakness, blood circulation disorder, etc. occur, and various pains are felt. This is a symptom called joint pain in a broad sense.
この症状を根本的に改善する方法としては磨り減った軟骨の補充が挙げられるが、かかる根本治療とは別に(または並行して)炎症や痛みを軽減することも重要であり、そのために従来から抗炎症作用を有する鎮痛成分を経口的に投与(摂取)することが行われており、そのための経口組成物も種々提案されている。例えば、特許文献1では、グルコサミンとプロピオン酸誘導体(鎮痛剤)を組み合わせた鎮痛製剤が、また特許文献2では、植物系生薬による鎮痛剤、抗酸化剤、ビタミン複合体及びグルコサミン等の複数の成分を組み合わせた鎮痛用健康補助食品が提案されている。しかしながら、鎮痛剤を用いた場合、胃粘膜障害などの副作用が生じることがある等の不具合があり、服用(摂取)を日常的に継続し難いという問題がある。一方で食品として使用できる成分を利用した場合は、鎮痛効果が十分でないという問題がある。 As a method of fundamentally ameliorating this symptom, replenishment of worn cartilage can be mentioned, but it is also important to reduce inflammation and pain separately from (or in parallel with) such fundamental treatment. Oral administration (ingestion) of an analgesic component having an anti-inflammatory action has been performed, and various oral compositions have been proposed. For example, Patent Document 1 discloses an analgesic preparation comprising a combination of glucosamine and a propionic acid derivative (analgesic), and Patent Document 2 discloses a plurality of components such as a plant herbal analgesic, an antioxidant, a vitamin complex and glucosamine. There has been proposed a health supplement for analgesia combining the above. However, when an analgesic is used, there is a problem that side effects such as gastric mucosal damage may occur, and there is a problem that it is difficult to continue taking (ingestion) on a daily basis. On the other hand, when an ingredient that can be used as a food is used, there is a problem that the analgesic effect is not sufficient.
上記の背景の下、昨今、抗炎症作用を有する物質としてグルコサミンが注目されている。その薬理作用等の研究も盛んに行われているものの、その抗炎症作用の増強に関しては、いまだ十分な研究がなされているとはいえない。 Under the above background, glucosamine has recently attracted attention as a substance having an anti-inflammatory action. Although research on the pharmacological action and the like has been actively conducted, it cannot be said that sufficient research has been conducted on the enhancement of the anti-inflammatory action.
本発明は、こうしたグルコサミンを始めとするグルコサミン化合物が有する抗炎症作用を増強し、関節炎などの炎症をより有効に改善することができる経口組成物を提供することを目的とする。また本発明は、グルコサミン化合物の抗炎症作用が増強してなるグルコサミン化合物含有組成物の製造方法を提供することを目的とする。 An object of the present invention is to provide an oral composition capable of enhancing the anti-inflammatory action of glucosamine compounds such as glucosamine, and more effectively improving inflammation such as arthritis. Another object of the present invention is to provide a method for producing a glucosamine compound-containing composition in which the anti-inflammatory action of the glucosamine compound is enhanced.
本発明者らは、上記目的を達成すべく、鋭意検討を重ねていたところ、グルコサミンを始めとするグルコサミン化合物に、含硫アミノ酸、アガロオリゴ糖、及びプロテオグリカンからなる群から選択される少なくとも1種を組み合わせることで、グルコサミン化合物が有する抗炎症作用が有意に増強することを見出し、特に関節炎の抗炎症用組成物として有効であることを確認した。 The inventors of the present invention have made extensive studies in order to achieve the above object. As a result, the glucosamine compound including glucosamine contains at least one selected from the group consisting of sulfur-containing amino acids, agarooligosaccharides, and proteoglycans. By combining, it discovered that the anti-inflammatory action which a glucosamine compound has increased significantly, and confirmed that it was especially effective as an anti-inflammatory composition of arthritis.
本発明はかかる知見に基づいて完成したものであり、下記の実施形態を有する。 The present invention has been completed based on such findings, and has the following embodiments.
(I)抗炎症作用強化グルコサミン化合物含有経口組成物
I−1.(A)グルコサミン化合物、並びに(B)含硫アミノ酸、アガロオリゴ糖、及びプロテオグリカンからなる群から選択される少なくとも1種を含有することを特徴とする経口組成物。
I−2.(A)グルコサミン化合物が、グルコサミン、N−アセチルグルコサミン、及びこれらの塩からなる群から選択される少なくとも1種であるI−1に記載する経口組成物。
I−3.(B)含硫アミノ酸がメチオニン、システイン、及びタウリンからなる群から選択される少なくとも1種であるI−1またはI−2に記載する経口組成物。
I−4.(A)成分1重量部に対して、(B)成分を0.04〜2.5重量部、好ましくは0.08〜1.2重量部、より好ましくは0.08〜0.28重量部の割合で含有する、I−1〜I−3のいずれかに記載する経口組成物。
(I) Oral composition containing anti-inflammatory action-enhancing glucosamine compound I-1. An oral composition comprising (A) a glucosamine compound, and (B) at least one selected from the group consisting of sulfur-containing amino acids, agarooligosaccharides, and proteoglycans.
I-2. (A) The oral composition described in 1-1, wherein the glucosamine compound is at least one selected from the group consisting of glucosamine, N-acetylglucosamine, and salts thereof.
I-3. (B) The oral composition described in I-1 or I-2, wherein the sulfur-containing amino acid is at least one selected from the group consisting of methionine, cysteine, and taurine.
I-4. The component (B) is 0.04 to 2.5 parts by weight, preferably 0.08 to 1.2 parts by weight, more preferably 0.08 to 0.28 parts by weight, based on 1 part by weight of the component (A). The oral composition according to any one of I-1 to I-3, which is contained in a proportion of
(II)抗炎症作用強化グルコサミン化合物含有経口組成物の製造方法
II−1.(A)グルコサミン化合物に、(B)含硫アミノ酸、アガロオリゴ糖、及びプロテオグリカンからなる群から選択される少なくとも1種を配合してグルコサミン化合物の抗炎症作用を増強させることを特徴とする、抗炎症作用強化グルコサミン化合物含有経口組成物の製造方法。
II−2.(A)グルコサミン化合物がグルコサミン、N−アセチルグルコサミン、及びこれらの塩からなる群から選択される少なくとも1種であるII−1に記載する製造方法。
II−3.(B)含硫アミノ酸がメチオニン、システイン、及びタウリンからなる群から選択される少なくとも1種であるII−1またはII−2に記載する製造方法。
II−4.(A)成分1重量部に対して、(B)成分を0.04〜2.5重量部、好ましくは0.08〜1.2重量部、より好ましくは0.08〜0.28重量部の割合で配合する、II−1〜II−3のいずれかに記載する製造方法。
(II) Method for producing oral composition containing glucosamine compound with enhanced anti-inflammatory action II-1. (A) Anti-inflammation characterized in that the glucosamine compound is combined with at least one selected from the group consisting of (B) sulfur-containing amino acids, agarooligosaccharides, and proteoglycans to enhance the anti-inflammatory action of the glucosamine compound A method for producing an oral composition containing an enhanced glucosamine compound.
II-2. (A) The production method according to II-1, wherein the glucosamine compound is at least one selected from the group consisting of glucosamine, N-acetylglucosamine, and salts thereof.
II-3. (B) The production method according to II-1 or II-2, wherein the sulfur-containing amino acid is at least one selected from the group consisting of methionine, cysteine, and taurine.
II-4. The component (B) is 0.04 to 2.5 parts by weight, preferably 0.08 to 1.2 parts by weight, more preferably 0.08 to 0.28 parts by weight, based on 1 part by weight of the component (A). The production method according to any one of II-1 to II-3, which is blended at a ratio of
なお、本発明は下記に記載するようにグルコサミン化合物が有する抗炎症作用を増強する方法を提供するものである。当該本発明の方法は、グルコサミン化合物の薬効である抗炎症作用を増強する方法、つまりグルコサミン化合物に対して行われる薬効増強方法であって、人に対して行われる治療方法でもまたそれを含むものでもない。 The present invention provides a method for enhancing the anti-inflammatory action of a glucosamine compound as described below. The method of the present invention is a method for enhancing the anti-inflammatory action, which is a medicinal effect of a glucosamine compound, that is, a method for enhancing the medicinal effect performed on a glucosamine compound, which also includes a therapeutic method performed on a person. not.
(III)グルコサミン化合物の抗炎症作用増強方法
III−1.(A)グルコサミン化合物に、(B)含硫アミノ酸、アガロオリゴ糖、及びプロテオグリカンからなる群から選択される少なくとも1種を配合することを特徴とする、グルコサミン化合物が有する抗炎症作用を増強させる方法(ただし、人に対する治療方法を除く)。
III−2.(A)グルコサミン化合物がグルコサミン、N−アセチルグルコサミン、及びこれらの塩からなる群から選択される少なくとも1種であるIII−1に記載する方法。
III−3.(B)含硫アミノ酸がメチオニン、システイン、及びタウリンからなる群から選択される少なくとも1種であるIII−1またはIII−2に記載する方法。
III−4.(A)成分1重量部に対して、(B)成分を0.04〜2.5重量部、好ましくは0.08〜1.2重量部、より好ましくは0.08〜0.28重量部の割合で配合する、III−1〜III−3のいずれかに記載する方法。
(III) Method for enhancing anti-inflammatory action of glucosamine compound III-1. (A) A method for enhancing the anti-inflammatory action of a glucosamine compound, characterized in that the glucosamine compound is blended with at least one selected from the group consisting of (B) a sulfur-containing amino acid, an agarooligosaccharide, and a proteoglycan ( (Excluding treatment methods for humans).
III-2. (A) The method according to III-1, wherein the glucosamine compound is at least one selected from the group consisting of glucosamine, N-acetylglucosamine, and salts thereof.
III-3. (B) The method according to III-1 or III-2, wherein the sulfur-containing amino acid is at least one selected from the group consisting of methionine, cysteine, and taurine.
III-4. The component (B) is 0.04 to 2.5 parts by weight, preferably 0.08 to 1.2 parts by weight, more preferably 0.08 to 0.28 parts by weight, based on 1 part by weight of the component (A). The method according to any one of III-1 to III-3, which is blended at a ratio of
本発明によれば、グルコサミンの抗炎症作用がより増強してなる抗炎症作用強化グルコサミン含有経口組成物を提供することができる。当該経口組成物によれば、グルコサミンが本来有する抗炎症作用が増強されているため、関節炎、関節捻挫、半月版損傷、靭帯損傷、変形性関節症、関節リウマチなどの炎症を治療または改善するために好適に使用することができる。また、本発明の経口組成物は、抗炎症作用が増強されるため、従来公知の消炎鎮痛剤を併用する必要がなく、このため、消炎鎮痛剤の配合に起因する胃粘膜障害などの副作用の招来を防止することができる。 ADVANTAGE OF THE INVENTION According to this invention, the anti-inflammatory action reinforcement | strengthening glucosamine containing oral composition in which the anti-inflammatory action of glucosamine is further enhanced can be provided. According to the oral composition, the anti-inflammatory action inherent to glucosamine is enhanced, so that the inflammation such as arthritis, joint sprain, meniscal damage, ligament damage, osteoarthritis, rheumatoid arthritis, etc. is treated or improved. Can be suitably used. Further, since the anti-inflammatory action of the oral composition of the present invention is enhanced, it is not necessary to use a known anti-inflammatory analgesic in combination, and as a result, side effects such as gastric mucosal disorder caused by the combination of the anti-inflammatory analgesic. Invitation can be prevented.
(I)抗炎症作用強化グルコサミン化合物含有経口組成物
本発明の経口組成物は、(A)グルコサミン化合物、並びに(B)含硫アミノ酸、アガロオリゴ糖、及びプロテオグリカンからなる群から選択される少なくとも1種を含有することを特徴とする。
(I) Oral Composition Containing Anti-Inflammatory Action Enhanced Glucosamine Compound The oral composition of the present invention is at least one selected from the group consisting of (A) a glucosamine compound, and (B) a sulfur-containing amino acid, an agarooligosaccharide, and a proteoglycan. It is characterized by containing.
(A)グルコサミン化合物
本発明が対象とするグルコサミン化合物には、グルコサミン及びその誘導体、並びにこれらの塩が含まれる。なお、グルコサミンは、2−アミノ−2−デオキシグルコースまたはキトサミンとも呼ばれる代表的なアミノ糖であり、当該グルコサミンには、D体、L体及びDL体のいずれでもが含まれる。
(A) Glucosamine compounds The glucosamine compounds targeted by the present invention include glucosamine and derivatives thereof, and salts thereof. Glucosamine is a typical amino sugar also called 2-amino-2-deoxyglucose or chitosamine, and the glucosamine includes any of D-form, L-form and DL-form.
グルコサミンの誘導体には、グルコサミンの水酸基またはアミノ基をアルキル基またはアシル基で置換した化合物が含まれる。例えば、グルコサミンの誘導体としては、グルコサミンのアミノ基をメチル基、エチル基、プロピル基、イソプロピル基、ブチル基、イソブチル基、sec-ブチル基、及びtert-ブチル基等の炭素数1〜6のアルキル基、またはアセチル基及びベンゾイル基等のアシル基で置換した化合物を挙げることができる。好ましくはグルコサミンのアミノ基をメチル基やエチル基といった炭素数1〜2のアルキル基で置換した化合物、及びグルコサミンのアミノ基をアセチル基で置換した化合物である。より好ましくは、グルコサミンのアミノ基をアセチル基で置換したN−アセチルグルコサミンである。 Derivatives of glucosamine include compounds in which the hydroxyl group or amino group of glucosamine is substituted with an alkyl group or an acyl group. For example, as a derivative of glucosamine, the amino group of glucosamine is an alkyl group having 1 to 6 carbon atoms such as methyl group, ethyl group, propyl group, isopropyl group, butyl group, isobutyl group, sec-butyl group, and tert-butyl group. And compounds substituted with an acyl group such as an acetyl group and a benzoyl group. A compound in which the amino group of glucosamine is substituted with an alkyl group having 1 to 2 carbon atoms such as a methyl group or an ethyl group, and a compound in which the amino group of glucosamine is substituted with an acetyl group are preferred. More preferred is N-acetylglucosamine in which the amino group of glucosamine is substituted with an acetyl group.
本発明のグルコサミン化合物には、上記グルコサミン及びその誘導体の塩も含まれる。当該塩は、グルコサミンまたはその誘導体の薬理学的に(製薬上)又は生理学的に許容される塩であればよく、特にその種類は限定されない。薬理学的又は生理学的に許容される塩としては、例えば、有機酸塩(例えば、酢酸塩、トリフルオロ酢酸塩、酪酸塩、パルミチン酸塩、及びステアリン酸塩などのモノカルボン酸塩;フマル酸塩やマレイン酸塩などの多価カルボン酸塩;乳酸塩、酒石酸塩、クエン酸塩、コハク酸塩、及びマロン酸塩などのオキシカルボン酸塩;メタンスルホン酸塩、トルエンスルホン酸塩、及びトシル酸塩などの有機スルホン酸塩など)、無機酸塩(例えば、塩酸塩、硫酸塩、硝酸塩、臭化水素酸塩、リン酸塩など)、有機塩基との塩、及び無機塩基との塩[例えば、アンモニウム塩;アルカリ金属(ナトリウム、カリウムなど)、アルカリ土類金属(カルシウム、マグネシウムなど)、アルミニウムなどの金属との塩など]などが例示できる。好ましくは、グルコサミン塩酸塩、グルコサミン硫酸塩である。特に好ましくはグルコサミン塩酸塩である。 The glucosamine compound of the present invention includes salts of the above glucosamine and derivatives thereof. The salt is not particularly limited as long as it is a pharmacologically (pharmaceutically) or physiologically acceptable salt of glucosamine or a derivative thereof. Examples of pharmacologically or physiologically acceptable salts include organic acid salts (for example, monocarboxylic acid salts such as acetate, trifluoroacetate, butyrate, palmitate, and stearate; fumaric acid Polyvalent carboxylates such as salts and maleates; oxycarboxylates such as lactate, tartrate, citrate, succinate, and malonate; methanesulfonate, toluenesulfonate, and tosyl Organic sulfonates such as acid salts), inorganic acid salts (eg, hydrochlorides, sulfates, nitrates, hydrobromides, phosphates, etc.), salts with organic bases, and salts with inorganic bases [ Examples include ammonium salts; alkali metals (sodium, potassium, etc.), alkaline earth metals (calcium, magnesium, etc.), salts with metals such as aluminum, etc.]. Glucosamine hydrochloride and glucosamine sulfate are preferable. Particularly preferred is glucosamine hydrochloride.
これらのグルコサミン化合物は、天然物から精製して得られる化合物であっても、また合成によって得られる化合物であってもよく、また市販のグルコサミンもしくはその誘導体またはそれらの塩も使用することができる。なお、本発明の経口組成物に配合するグルコサミン化合物は、上記のグルコサミン及びその誘導体、並びにこれらの塩から選択される一種であってもよいし、また二種以上の任意の組み合わせであってもよい。 These glucosamine compounds may be compounds obtained by purification from natural products, or compounds obtained by synthesis, and commercially available glucosamine or derivatives thereof, or salts thereof can also be used. The glucosamine compound to be blended in the oral composition of the present invention may be one selected from the above-mentioned glucosamine and derivatives thereof, and salts thereof, or may be any combination of two or more. Good.
本発明の経口組成物中に配合するグルコサミン化合物の割合は、本発明の効果を奏する範囲であれば特に制限されないものの、通常23〜90重量%(総量)の範囲から選択することができる。好ましくは26〜89重量%であり、より好ましくは50〜88重量%である。 Although the ratio of the glucosamine compound mix | blended in the oral composition of this invention will not be restrict | limited especially if it is a range with the effect of this invention, it can select from the range of 23 to 90 weight% (total amount) normally. Preferably it is 26 to 89 weight%, More preferably, it is 50 to 88 weight%.
(B)含硫アミノ酸、アガロオリゴ糖、及びプロテオグリカン
(B−1)含硫アミノ酸
上記グルコサミンと併用する含硫アミノ酸とは硫黄を含むアミノ酸の総称である。具体的には、メチオニン、システイン、シスチン、シスタチオニン、及びタウリンを挙げることができる。好ましくはメチオニン、及びシステインである。これらは一種単独で、本発明の経口組成物に配合することができるが、二種以上を任意に併用して使用することもできる。
(B) Sulfur-containing amino acids, agarooligosaccharides, and proteoglycans
(B-1) Sulfur-containing amino acid The sulfur-containing amino acid used in combination with the glucosamine is a general term for amino acids containing sulfur. Specific examples include methionine, cysteine, cystine, cystathionine, and taurine. Preferred are methionine and cysteine. These can be used alone or in combination with the oral composition of the present invention, but two or more can be used in combination.
本発明の経口組成物中に配合する含硫アミノ酸の割合は、本発明の効果を奏する範囲であれば特に制限されないものの、通常0.9〜70重量%(総量)の範囲から選択することができる。好ましくは4〜50重量%であり、より好ましくは7〜21重量%である。
また、本発明の経口組成物中に含まれるグルコサミン化合物1重量部に対する含硫アミノ酸の配合割合も、本発明の効果を奏する範囲であればよく、通常0.04〜2.5重量部の割合から選択することができる。当該割合の下限値として、好ましくは0.08重量部、を挙げることができる。また上限値として、好ましくは2重量部、より好ましくは1.2重量部、特に好ましくは0.28重量部を挙げることができる。
The ratio of the sulfur-containing amino acid to be blended in the oral composition of the present invention is not particularly limited as long as the effect of the present invention is achieved, but it is usually selected from the range of 0.9 to 70% by weight (total amount). it can. Preferably it is 4 to 50 weight%, More preferably, it is 7 to 21 weight%.
Moreover, the compounding ratio of the sulfur-containing amino acid with respect to 1 part by weight of the glucosamine compound contained in the oral composition of the present invention may be within the range where the effects of the present invention are exhibited, and the ratio is usually 0.04 to 2.5 parts by weight You can choose from. The lower limit value of the ratio is preferably 0.08 part by weight. The upper limit is preferably 2 parts by weight, more preferably 1.2 parts by weight, and particularly preferably 0.28 parts by weight.
(B−2)アガロオリゴ糖
アガロオリゴ糖は、構成単位であるD−ガラクトシル−(β1→4)−3,6−アンヒドロ−α−ガラクトース(=アガロビオース:ガラクトースと3,6−アンハイドロガラクトースからなる2糖)がα1、3結合で結合し、3,6−アンハイドロガラクトピラノースを還元末端に有するオリゴ糖である。アガロオリゴ糖としては、アガロビオース(2糖)、アガロテトラオース(4糖)、アガロヘキサオース(6糖)、アガロオクタオース(8糖)、及びアガロデカオース(10糖)が例示される。好ましくはアガロビオース(2糖)、アガロテトラオース(4糖)、アガロヘキサオース(6糖)、及びアガロオクタオース(8糖)である。本発明においては、1種のアガロオリゴ糖を単独で用いても良いし、2種以上のアガロオリゴ糖の混合物を用いても良い。アガロオリゴ糖は、公知の製法により製造されるものを使用することができ、特に限定されないものの、例えば、国際公開第00/69285号パンフレットに記載の製法に従って製造することができる。当該方法は、具体的には原料寒天を固体酸により酸分解する方法であり、当該方法で得られるアガロビオース、アガロテトラオース、アガロヘキサオース、及びアガロオクタオースを含有するアガロオリゴ糖の混合物を、本発明のアガロオリゴ糖として使用することもできる。なお、このように原料として寒天を用いて調製されたアガロオリゴ糖は、寒天オリゴ糖と呼ばれることもあり、本発明で使用するアガロオリゴ糖には当該寒天オリゴ糖が包含される。アガロビオース、アガロテトラオース、アガロヘキサオース、及びアガロオクタオースを含有するアガロオリゴ糖の混合物としては、市販のものを使用することができ、かかるものとしてアガオリゴ(登録商標)(タカラバイオ社製)、を使用することもできる。
(B-2) Agarooligosaccharide Agarooligosaccharide is a structural unit of D-galactosyl- (β1 → 4) -3,6-anhydro-α-galactose (= Agarobiose: 2 consisting of galactose and 3,6-anhydrogalactose. (Sugar) is an oligosaccharide having α1,3 bonds and 3,6-anhydrogalactopyranose at the reducing end. Examples of agarooligosaccharides include agarobiose (disaccharide), agarotetraose (tetrasaccharide), agarohexaose (hexasaccharide), agarooctaose (octasaccharide), and agarodecaose (10 sugar). Agarobiose (disaccharide), agarotetraose (tetrasaccharide), agarohexaose (hexasaccharide), and agarooctaose (octasaccharide) are preferable. In the present invention, one kind of agarooligosaccharide may be used alone, or a mixture of two or more kinds of agarooligosaccharide may be used. As the agarooligosaccharide, those produced by a known production method can be used, and although not particularly limited, for example, it can be produced according to the production method described in International Publication No. 00/69285 pamphlet. The method is specifically a method in which raw material agar is acid-decomposed with a solid acid, and a mixture of agarobiose, agarotetraose, agarohexaose, and agaro-oligosaccharide containing agarooctaose obtained by the method. Can also be used as the agarooligosaccharide of the present invention. In addition, the agarooligosaccharide prepared using agar as a raw material in this way is sometimes called an agar oligosaccharide, and the agarooligosaccharide used in the present invention includes the agar oligosaccharide. As a mixture of agaro-oligosaccharides containing agarobiose, agarotetraose, agarohexaose and agarooctaose, commercially available products can be used, and as such, aga-oligo (registered trademark) (manufactured by Takara Bio Inc.) ), Can also be used.
本発明の経口組成物中に配合するアガロオリゴ糖の割合は、本発明の効果を奏する範囲であれば特に制限されないものの、通常0.9〜70重量%(総量)の範囲から選択することができる。好ましくは4〜70重量%であり、より好ましくは45〜70重量%である。 The ratio of the agarooligosaccharide compounded in the oral composition of the present invention is not particularly limited as long as the effect of the present invention is achieved, but can be selected from the range of usually 0.9 to 70% by weight (total amount). . Preferably it is 4-70 weight%, More preferably, it is 45-70 weight%.
また、本発明の経口組成物中に含まれるグルコサミン化合物1重量部に対するアガロオリゴ糖の配合割合も、本発明の効果を奏する範囲であればよく、通常0.04〜2.5重量部の割合から選択することができる。当該割合の下限値として、好ましくは0.08重量部、より好ましくは0.1重量部、さらに好ましくは0.2重量部、特に好ましくは1.0重量部を挙げることができる。また上限値として、好ましくは2.5重量部を挙げることができる。 Moreover, the blending ratio of the agarooligosaccharide with respect to 1 part by weight of the glucosamine compound contained in the oral composition of the present invention may also be within a range where the effects of the present invention can be achieved, and usually from a ratio of 0.04 to 2.5 parts by weight. You can choose. The lower limit of the ratio is preferably 0.08 parts by weight, more preferably 0.1 parts by weight, still more preferably 0.2 parts by weight, and particularly preferably 1.0 parts by weight. The upper limit is preferably 2.5 parts by weight.
(B−3)プロテオグリカン
プロテオグリカン(Proteoglycan)は、ムコ多糖とタンパク質の複合体であり、糖タンパク質の一種である。当該複合体は、全体の5〜50%を占めるタンパク質のポリペプチド鎖をコアとして、これに数本ないしは数十本のムコ多糖類の鎖が結合してなる平均分子量20万〜2000万程度の酸性ムコ多糖類−タンパク質複合体である。平均分子量として、好ましくは50万〜2000万程度であり、より好ましくは100万〜1000万程度、特に好ましくは500万〜1000万である。
(B-3) Proteoglycan Proteoglycan (Proteoglycan) is a complex of mucopolysaccharide and protein, and is a kind of glycoprotein. The complex has an average molecular weight of about 200,000 to 20 million, consisting of a protein polypeptide chain occupying 5 to 50% of the whole as a core, and several or dozens of mucopolysaccharide chains bonded thereto. It is an acidic mucopolysaccharide-protein complex. The average molecular weight is preferably about 500,000 to 20 million, more preferably about 1 million to 10 million, and particularly preferably 5 million to 10 million.
プロテオグリカンの構成酸性ムコ多糖類としては、主としてヒアルロン酸、コンドロイチン、コンドロイチン硫酸、デルマタン硫酸、ヘパリン、ヘパリチン硫酸、及びケラト硫酸等を挙げることができる。ここでコンドロイチン硫酸には、グルクロン酸とアセチルガラクトサミン4硫酸を主成分とするコンドロイチン硫酸A(コンドロイチン4硫酸)、イズロン酸2硫酸とアセチルガラクトサミン4硫酸を主成分とするコンドロイチン硫酸B(コンドロイチン2,4硫酸)、及びグルクロン酸とアセチルガラクトサミン6硫酸を主成分とするコンドロイチン硫酸C(コンドロイチン6硫酸)、グルクロン酸2硫酸とアセチルガラクトサミン6硫酸を主成分とするコンドロイチン硫酸D(コンドロイチン2,6硫酸)、グルクロン酸とアセチルガラクトサミン4,6二硫酸を主成分とするコンドロイチン硫酸E(コンドロイチン4,6硫酸)が含まれる。プロテオグリカンの構成酸性ムコ多糖類として、好ましくはコンドロイチン硫酸A、コンドロイチン硫酸B、コンドロイチン硫酸Dであり、なかでも好ましくはコンドロイチン硫酸Dである。本発明で使用するプロテオグリカンは、一種単独からなるものであってもよいし、また構成酸性ムコ多糖類を異にする二種以上のプロテオグリカンの混合物であってもよい。 Examples of the acidic mucopolysaccharides constituting proteoglycans mainly include hyaluronic acid, chondroitin, chondroitin sulfate, dermatan sulfate, heparin, heparitin sulfate, and keratosulfuric acid. Here, chondroitin sulfate includes chondroitin sulfate A (chondroitin sulfate 4) mainly composed of glucuronic acid and acetylgalactosamine 4 sulfate, chondroitin sulfate A (chondroitin 4 sulfate), iduronic acid 2 sulfate and acetylgalactosamine 4 sulfate. Sulfuric acid), and chondroitin sulfate C (chondroitin 6 sulfate) mainly composed of glucuronic acid and acetylgalactosamine 6 sulfate, chondroitin sulfate D (chondroitin 2,6 sulfate) mainly composed of glucuronic acid 2 sulfate and acetylgalactosamine 6 sulfate, Chondroitin sulfate E (chondroitin 4,6 sulfate) mainly composed of glucuronic acid and acetylgalactosamine 4,6 disulfate is included. Preferred acidic mucopolysaccharides of proteoglycans are chondroitin sulfate A, chondroitin sulfate B, and chondroitin sulfate D, and chondroitin sulfate D is particularly preferable. The proteoglycan used in the present invention may be composed of one kind alone, or may be a mixture of two or more kinds of proteoglycans having different constituent acidic mucopolysaccharides.
プロテオグリカンは、動物(ほ乳類:牛等、魚類:鮭等)組織、主に細胞外マトリックスや細胞表面に存在し、多くの組織細胞間の空間を満たすジェリー状の細胞間質及び細胞間セメント、軟骨、腱、皮膚、関節を滑らかにする骨液に含まれている。本発明で使用するプロテオグリカンは、かかる組織等から分離精製されたものであっても、またその粗精製物であってもよい。プロテオグリカンの定量は、ゲルクロマトグラフィーを用いて分子量分画を行ない、分子量が20万以上でかつ酸性糖および蛋白質の存在が確認された画分の乾燥物を測定することで行なうことができる。なお、酸性糖の存在は、カルバゾール硫酸法で、蛋白質の存在は、280nm付近における吸光度測定で確認することができる。簡便には、市販のプロテオグリカンを使用することができ、かかるものとしてプロテオグリカンF(一丸ファルコス社製)、を使用することもできる。 Proteoglycans are present in animal tissues (mammals: cattle, etc., fish: sharks, etc.), mainly in the extracellular matrix and cell surface, and in the form of jelly-like cell stroma and intercellular cement that fills the space between many tissues. Contained in bone fluid, smoothing tendons, skin, joints. The proteoglycan used in the present invention may be separated and purified from such tissues or the like, or may be a crude product thereof. Proteoglycan can be quantified by performing molecular weight fractionation using gel chromatography and measuring the dried product of the fraction having a molecular weight of 200,000 or more and the presence of acidic sugars and proteins. The presence of acidic sugar can be confirmed by the carbazole sulfate method, and the presence of protein can be confirmed by absorbance measurement at around 280 nm. For convenience, commercially available proteoglycans can be used, and proteoglycan F (manufactured by Ichimaru Falcos) can also be used as such.
本発明の経口組成物中に配合するプロテオグリカンの割合は、本発明の効果を奏する範囲であれば特に制限されないものの、通常0.9〜70重量%(総量)の範囲から選択することができる。好ましくは0.9〜35重量%であり、より好ましくは4〜16重量%である。 Although the ratio of the proteoglycan blended in the oral composition of the present invention is not particularly limited as long as the effect of the present invention is exhibited, it can be selected from the range of usually 0.9 to 70% by weight (total amount). Preferably it is 0.9 to 35 weight%, More preferably, it is 4 to 16 weight%.
また、本発明の経口組成物中に含まれるグルコサミン化合物1重量部に対するプロテオグリカンの配合割合も、本発明の効果を奏する範囲であればよく、通常0.04〜2.5重量部の割合から選択することができる。当該割合の下限値として、好ましくは0.05重量部、より好ましくは0.08重量部を挙げることができる。また上限値として、好ましくは2重量部、より好ましくは1重量部、特に好ましくは0.2重量部を挙げることができる。 Moreover, the blending ratio of proteoglycan with respect to 1 part by weight of the glucosamine compound contained in the oral composition of the present invention may be within the range where the effect of the present invention is exerted, and is usually selected from a ratio of 0.04 to 2.5 parts by weight. can do. The lower limit of the ratio is preferably 0.05 parts by weight, more preferably 0.08 parts by weight. The upper limit is preferably 2 parts by weight, more preferably 1 part by weight, and particularly preferably 0.2 parts by weight.
(C)その他の成分
本発明の経口組成物は、本発明の効果を妨げない限り、上記の成分に加えて、さらに必要に応じて、他の成分を含有することができる。例えば、アガリクス、シイタケエキス、レイシ、ヤマブシタケ等のきのこ類又はその抽出物;イソフラボン、エクオール、カテキン、アントシアニン、プロアントシアニジン等のポリフェノール;カルシウム、マグネシウム、イオウ、亜鉛、セレン、鉄等のミネラル類;グリシン、アラニン、アルギニン、リジン、プロリン等のアミノ酸;ビタミンB1、ビタミンB2、ビタミンB6、ビタミンB12、ビタミンC、ビタミンA、ビタミンD、ビタミンE、ビタミンK、ナイアシン、パントテン酸、葉酸、ビオチン、リコペン等のビタミン類;シャクヤク、カンゾウ、デビルズクロー、キャッツクロー等の植物又はその抽出物;ポリデキストロース、難消化性デキストリン、デキストリン、ショ糖、果糖、アスパルテーム、マルチトール、アセスルファムK等の甘味料;食物繊維、ローヤルゼリー、プロポリス、蜂蜜、セラミド、メチルスルフォニルメタン等のその他の機能性素材等を挙げることができる。
(C) Other components The oral composition of the present invention may contain other components as required in addition to the above components, as long as the effects of the present invention are not hindered. For example, mushrooms such as agaricus, shiitake extract, litchi, yamabushitake or extracts thereof; polyphenols such as isoflavones, equol, catechin, anthocyanins, proanthocyanidins; minerals such as calcium, magnesium, sulfur, zinc, selenium, iron; glycine , Amino acids such as alanine, arginine, lysine, proline; vitamin B1, vitamin B2, vitamin B6, vitamin B12, vitamin C, vitamin A, vitamin D, vitamin E, vitamin K, niacin, pantothenic acid, folic acid, biotin, lycopene, etc. Vitamins; plants such as peony, licorice, devil's claw, cat's claw or extracts thereof; polydextrose, indigestible dextrin, dextrin, sucrose, fructose, aspartame, maltitol, acetol Surufamu K such sweeteners; dietary fiber, mention may be made of royal jelly, propolis, honey, ceramides, and other functional materials such as methylsulfonyl methane.
当該他の成分は、本発明の経口組成物の適用用途および形態に応じて、適宜設定することができる。例えば、本発明の経口組成物を飲食物、経口医薬部外品、及び経口医薬品として用いる場合は、これらの用途に応じて、またその形態(錠剤、カプセル剤(ハードカプセル、ソフトカプセル)、散剤、顆粒剤、丸剤、液剤、乳剤、懸濁液、溶液剤、酒精剤、シロップ剤、エキス剤)などに応じて、例えば、賦形剤、増量剤、結合剤、増粘剤、乳化剤、滑沢剤、湿潤剤、懸濁剤、着色料、呈味剤、および香料などの成分を目的に応じて配合することができる。 The other components can be appropriately set according to the application and form of the oral composition of the present invention. For example, when the oral composition of the present invention is used as a food or drink, an oral quasi-drug, or an oral pharmaceutical, its form (tablet, capsule (hard capsule, soft capsule), powder, granule, etc.) depends on these uses. Agents, pills, solutions, emulsions, suspensions, solutions, spirits, syrups, extracts, etc.), for example, excipients, extenders, binders, thickeners, emulsifiers, lubricants Components such as an agent, a wetting agent, a suspending agent, a coloring agent, a flavoring agent, and a flavoring agent can be blended depending on the purpose.
(II)抗炎症作用強化グルコサミン化合物含有経口組成物(製造方法、用途)
本発明の経口組成物は、上記(A)成分と(B)成分とを組み合わせて、これらを必要に応じて(C)のその他の成分とともに、当業者が通常用いる方法によって混合し、各種の経口投与若しくは経口摂取される形態にすることで調製することができる。本発明の経口組成物の当該製造方法は、(A)成分であるグルコサミン化合物と(B)成分とを組み合わせることで、(A)成分の抗炎症作用を増強させることができることを特徴とする。
(II) Oral composition containing glucosamine compound with enhanced anti-inflammatory action (production method, use)
The oral composition of the present invention is a combination of the above components (A) and (B), and these are mixed together with other components (C) as required by methods commonly used by those skilled in the art. It can be prepared in a form that is orally administered or ingested. The said manufacturing method of the oral composition of this invention can enhance the anti-inflammatory action of (A) component by combining the glucosamine compound which is (A) component, and (B) component.
本発明の経口組成物は、経口の医薬品または医薬部外品として調製することができる。かかる経口組成物は、種々の剤形、例えば、経口投与形態として、錠剤、カプセル剤(ハードカプセル、ソフトカプセル)、散剤、顆粒剤、丸剤、液剤、乳剤、懸濁液、溶液剤、酒精剤、シロップ剤、エキス剤等とすることができる。かかる医薬品は、一般に用いられる各種成分を含むことができ、例えば、1種もしくはそれ以上の薬学的に許容され得る賦形剤、崩壊剤、希釈剤、滑沢剤、着香剤、着色剤、甘味剤、矯味剤、懸濁化剤、湿潤剤、乳化剤、分散剤、補助剤、防腐剤、緩衝剤、結合剤、安定剤、コーティング剤等を挙げることができる。また本発明の経口組成物は、持続性または徐放性剤形であってもよい。 The oral composition of the present invention can be prepared as an oral drug or quasi drug. Such oral compositions are available in various dosage forms such as tablets, capsules (hard capsules, soft capsules), powders, granules, pills, solutions, emulsions, suspensions, solutions, spirits, A syrup, an extract or the like can be used. Such pharmaceuticals can contain various commonly used ingredients such as one or more pharmaceutically acceptable excipients, disintegrants, diluents, lubricants, flavoring agents, coloring agents, Sweetening agents, flavoring agents, suspending agents, wetting agents, emulsifying agents, dispersing agents, auxiliary agents, preservatives, buffering agents, binders, stabilizers, coating agents and the like can be mentioned. The oral composition of the present invention may be in a sustained or sustained release dosage form.
かかる経口組成物の投与量は、投与経路、患者(炎症患者)の体型、年齢、体調、炎症の度合い等により、適宜選択することができる。制限はされないが、一般に経口組成物中に含まれるグルコサミン化合物の投与量に換算して250〜2000mg/日/成人、好ましくは500〜1800mg/日/成人の用量で使用されうる。当該経口組成物の投与は、1日当たり単回投与または複数回投与であってもよい。 The dose of the oral composition can be appropriately selected depending on the administration route, the patient's (inflammatory patient) body shape, age, physical condition, degree of inflammation, and the like. Although not limited, it can be generally used at a dose of 250 to 2000 mg / day / adult, preferably 500 to 1800 mg / day / adult in terms of the dose of the glucosamine compound contained in the oral composition. Administration of the oral composition may be a single dose or multiple doses per day.
本発明の経口組成物は、食品組成物として調製することもできる。当該食品組成物には、抗炎症効果を有する機能性食品(特定保健用食品が含まれる)、健康食品、及び栄養補助食品などのいわゆる機能性食品が含まれる。これらの食品組成物(機能性食品を含む)としては、制限されないものの、錠剤、カプセル剤(ハードカプセル、ソフトカプセル)、散剤、顆粒剤、丸剤、液剤、懸濁剤、乳剤、ゼリー剤、チュアブル剤などの経口投与製剤形態を有するサプリメント(栄養補助食品)等が含まれる。また、本発明が対象とする経口組成物には、食品(飲料を含む)に抗炎症作用を付与するために使用される可食性組成物である食品添加物が含まれる。当該食品添加剤は、抗炎症効果を有する飲食物(上記機能性食品を含む)を製造するために好適に使用することができ、このため「抗炎症作用付与/強化用の食品用添加剤」ということもできる。 The oral composition of the present invention can also be prepared as a food composition. The food composition includes so-called functional foods such as functional foods having anti-inflammatory effects (including foods for specified health use), health foods, and nutritional supplements. These food compositions (including functional foods) include, but are not limited to, tablets, capsules (hard capsules, soft capsules), powders, granules, pills, liquids, suspensions, emulsions, jellies, chewables Supplements (nutritional supplements) having oral dosage forms such as are included. In addition, the oral composition targeted by the present invention includes a food additive that is an edible composition used for imparting an anti-inflammatory effect to foods (including beverages). The food additive can be suitably used for producing foods and drinks (including the functional foods) having an anti-inflammatory effect. For this reason, “food additives for imparting / strengthening anti-inflammatory effects” It can also be said.
かかる経口組成物の推奨摂取量は、上記医薬品及び医薬部外品の投与量に準じて決定することができる。また当該食品組成物は、上記医薬品及び医薬部外品と同様に、1日あたり単回摂取してもよいし、また複数回摂取してもよい。 The recommended intake of such an oral composition can be determined according to the doses of the above pharmaceutical products and quasi drugs. Moreover, the said food composition may be ingested once per day similarly to the said pharmaceutical and quasi-drug, and may be ingested in multiple times.
本発明の経口組成物は、後述する実験例に示すように、本来グルコサミンが有する抗炎症作用が有意に増強されており、抗炎症剤として好適に使用することができる。具体的には、関節炎、関節捻挫、半月版損傷、靭帯損傷、変形性関節症、関節リウマチ等の疾患や症状を有する患者(被験者)に対して、その症状を改善若しくは緩和する目的で好適に使用することができる。 As shown in the experimental examples described later, the oral composition of the present invention has a significantly enhanced anti-inflammatory action inherent to glucosamine, and can be suitably used as an anti-inflammatory agent. Specifically, for patients (subjects) having diseases or symptoms such as arthritis, joint sprains, half-moon damage, ligament damage, osteoarthritis, rheumatoid arthritis, etc., preferably for the purpose of improving or alleviating the symptoms Can be used.
(II)グルコサミン化合物の抗炎症作用増強方法
本発明のグルコサミン化合物の抗炎症作用増強方法は、グルコサミン化合物が本来有する薬理作用である抗炎症作用を増強するための方法である。
(II) Method for enhancing anti-inflammatory action of glucosamine compound The method for enhancing the anti-inflammatory action of the glucosamine compound of the present invention is a method for enhancing the anti-inflammatory action which is a pharmacological action inherent to the glucosamine compound.
当該方法は、(A)グルコサミン化合物に対して、前述する(B)含硫アミノ酸、アガロオリゴ糖、及びプロテオグリカンからなる群から選択される少なくとも1種を組み合わせることで実施することができる。つまり、(A)グルコサミン化合物に上記(B)成分を併用することで、グルコサミン化合物が有する抗炎症作用を増強することが可能になる。 The method can be carried out by combining (A) the glucosamine compound with at least one selected from the group consisting of (B) the sulfur-containing amino acid, agarooligosaccharide, and proteoglycan described above. That is, by using the component (B) in combination with the (A) glucosamine compound, the anti-inflammatory action of the glucosamine compound can be enhanced.
(A)グルコサミン化合物に対する(B)成分の配合割合は、上記(I)で説明した通りである。 (A) The mixture ratio of the (B) component with respect to a glucosamine compound is as having demonstrated in said (I).
具体的には、(B)成分として含硫アミノ酸を併用する場合、グルコサミン化合物1重量部に対する含硫アミノ酸の配合割合としては、通常0.04〜2.5重量部の範囲から選択することができる。当該割合の下限値として、好ましくは0.08重量部を挙げることができる。また上限値として、好ましくは2重量部、より好ましくは1.2重量部、特に好ましくは0.28重量部を挙げることができる。 Specifically, when a sulfur-containing amino acid is used in combination as the component (B), the blending ratio of the sulfur-containing amino acid to 1 part by weight of the glucosamine compound is usually selected from the range of 0.04 to 2.5 parts by weight. it can. The lower limit value of the ratio is preferably 0.08 part by weight. The upper limit is preferably 2 parts by weight, more preferably 1.2 parts by weight, and particularly preferably 0.28 parts by weight.
また、(B)成分としてアガロオリゴ糖を併用する場合、グルコサミン化合物1重量部に対するアガロオリゴ糖の配合割合は、通常0.04〜2.5重量部の割合から選択することができる。当該割合の下限値として、好ましくは0.08重量部、より好ましくは0.1重量部、さらに好ましくは0.2重量部、特に好ましくは1.0重量部を挙げることができる。また上限値として、好ましくは2.5重量部を挙げることができる。 Moreover, when using together agaro-oligosaccharide as (B) component, the compounding ratio of agarooligosaccharide with respect to 1 weight part of glucosamine compounds can be normally selected from the ratio of 0.04-2.5 weight part. The lower limit of the ratio is preferably 0.08 parts by weight, more preferably 0.1 parts by weight, still more preferably 0.2 parts by weight, and particularly preferably 1.0 parts by weight. The upper limit is preferably 2.5 parts by weight.
さらに(B)成分としてプロテオグリカンを併用する場合、グルコサミン化合物1重量部に対するプロテオグリカンの配合割合は、通常0.04〜2.5重量部の割合から選択することができる。当該割合の下限値として、好ましくは0.05重量部、より好ましくは0.08重量部を挙げることができる。また上限値として、好ましくは2重量部、より好ましくは1重量部、特に好ましくは0.2重量部を挙げることができる。 Furthermore, when using a proteoglycan together as (B) component, the compounding ratio of the proteoglycan with respect to 1 part by weight of the glucosamine compound can be usually selected from a ratio of 0.04 to 2.5 parts by weight. The lower limit of the ratio is preferably 0.05 parts by weight, more preferably 0.08 parts by weight. The upper limit is preferably 2 parts by weight, more preferably 1 part by weight, and particularly preferably 0.2 parts by weight.
斯くして、グルコサミン化合物が有する抗炎症作用を増強することができる。なお、当該方法は、上記説明から明らかな通り、抗炎症作用が増強されたグルコサミン化合物含有組成物の調製に関するものであり、人に投与する工程を有するものではない。よって、人に対する治療方法ではなく、また人に対する治療方法を包含するものでもない。 Thus, the anti-inflammatory action of the glucosamine compound can be enhanced. In addition, the said method is related with preparation of the glucosamine compound containing composition by which the anti-inflammatory action was enhanced as evident from the said description, and does not have a process administered to a person. Therefore, it is not a treatment method for a person, nor does it encompass a treatment method for a person.
以下に本発明の構成及び効果をより明らかに示すために、実験例(実施例及び比較例を含む)を示す。ただし、当該実験例等は本発明の理解を容易にするための一例であり、本件発明の範囲は、かかる実験例等によって拘束されるものではない。 In order to show the configuration and effects of the present invention more clearly, experimental examples (including examples and comparative examples) are shown below. However, the experimental example is an example for facilitating understanding of the present invention, and the scope of the present invention is not limited by the experimental example.
なお、下記の実施例及び比較例で使用した成分の商品名と入手先は下記の通りである。
グルコサミン:商品名「グルコサミンGM−C」、プロテインケミカル株式会社
システイン: 商品名「L−システイン」、プロテインケミカル株式会社
メチオニン:商品名「L−メチオニン」、プロテインケミカル株式会社
アガロオリゴ糖:商品名「TaKaRa アガオリゴ」、タカラバイオ株式会社
プロテオグリカン:商品名「プロテオグリカンF」、一丸ファルコス株式会社
ヒアルロン酸:商品名「ヒアルロン酸LM」、アイズ株式会社
オリーブ葉エキス:商品名「オラリス」、タマ生化学株式会社
クルクミン:商品名「MERIVAメリーバ(ウコン・フィトソーム)」、インデナジャパン株式会社
赤ショウガエキス:商品名「赤ショウガエキス-P」、オリザ油化株式会社
西洋ヤナギエキス:商品名「セイヨウヤナギカンソウエキス15%」、インデナジャパン株式会社
タウリン:商品名「アミノエチルスルホン酸(タウリンパウダー)」、本荘ケミカル株式会社
In addition, the brand name and acquisition place of the component used by the following Example and comparative example are as follows.
Glucosamine: Trade name “Glucosamine GM-C”, Protein Chemical Co., Ltd. Cysteine: Trade name “L-cysteine”, Protein Chemical Co., Ltd. Methionine: Trade name “L-methionine”, Protein Chemical Co., Ltd. Agaro-oligosaccharide: Trade name “TaKaRa” Agaoligo, Takara Bio Inc. Proteoglycan: Trade name “Proteoglycan F”, Ichimaru Falcos Co., Ltd. Hyaluronic acid: Trade name “Hyaluronic acid LM”, Eyes Inc. Olive leaf extract: Trade name “Oralis”, Tama Seikagaku Co., Ltd. Curcumin : Trade name "MERIVA Meriba (turmeric phytosome)", Indena Japan Co., Ltd. Red Ginger Extract: Trade name "Red Ginger Extract-P", Oriza Oily Co., Ltd. Western willow extract: Trade name "Pillus cricket extract 15% "Indenaja Taurine Bread Co., Ltd .: Trade name “Aminoethylsulfonic acid (taurine powder)”, Honjo Chemical Co., Ltd.
実験例1 滑膜細胞を用いた抗炎症作用の評価
MH7A(ヒト関節リウマチ患者滑膜細胞株)を用いて、表1及び表2に記載する種々の経口組成物(実施例1〜11、比較例1〜5)の炎症性サイトカイン(IL-8)放出に対する抑制作用(抗炎症作用)を評価した。当該方法は、具体的にはMH7AにIL-1β刺激を加えた際にIL-8が放出されることを利用して、上記各経口組成物を加えた場合に、IL-8放出がどのように変化するかを測定することにより、当該経口組成物の抗炎症作用を評価する方法である。経口組成物無添加のときのIL-8濃度よりも添加時のIL-8濃度が低下すれば、当該経口組成物に抗炎症作用がありと判断され、その逆の場合は抗炎症作用がなしと判断される。
Experimental Example 1 Evaluation of anti-inflammatory action using synoviocytes Using MH7A (human rheumatoid arthritis patient synovial cell line), various oral compositions described in Tables 1 and 2 (Examples 1 to 11, comparison) The inhibitory action (anti-inflammatory action) on the release of inflammatory cytokine (IL-8) in Examples 1 to 5) was evaluated. Specifically, the method uses IL-8 released when IL-1β stimulation is applied to MH7A, and how IL-8 is released when each oral composition is added. It is a method for evaluating the anti-inflammatory action of the oral composition by measuring whether it changes. If the IL-8 concentration when added is lower than the IL-8 concentration when no oral composition is added, the oral composition is judged to have an anti-inflammatory effect, and vice versa. It is judged.
下記に実験方法、判定方法及び実験結果を記載する。 The experimental method, determination method and experimental result are described below.
1.実験方法
(1)MH7Aを24well plateに0.35×105cells/wellの割合で播種し、37℃条件下(5%CO2)で24時間培養する。
(2)各wellに「グルコサミン単独」(比較例0)、「グルコサミン+各種成分」(実施例1〜11、比較例1〜5)をそれぞれ添加し、37℃条件下(5%CO2)で3時間培養する。なお、「グルコサミン単独」、及び「グルコサミン+各種成分」はいずれも各成分を所定濃度になるように水(溶媒)に溶解して調製しておく。また、別途、wellに当該溶媒だけ(有効成分含有せず)を10μl添加し、上記と同じ条件で培養し、これをコントロールとする。
(3)IL-1βを各wellに50 pg/mlとなるように添加し、24時間培養する。
(4)培養物からその上清を回収し、上清中のIL-8の濃度を測定する。
1. Experimental method (1) MH7A is seeded on a 24-well plate at a rate of 0.35 × 10 5 cells / well and cultured at 37 ° C. (5% CO 2 ) for 24 hours.
(2) “Glucosamine alone” (Comparative Example 0) and “Glucosamine + various components” (Examples 1 to 11 and Comparative Examples 1 to 5) were added to each well, respectively, at 37 ° C. (5% CO 2 ). Incubate for 3 hours. “Glucosamine alone” and “glucosamine + various components” are prepared by dissolving each component in water (solvent) so as to have a predetermined concentration. Separately, 10 μl of the solvent alone (not containing the active ingredient) is added to the well, and cultured under the same conditions as described above, which is used as a control.
(3) Add IL-1β to each well at 50 pg / ml and incubate for 24 hours.
(4) The supernatant is collected from the culture, and the concentration of IL-8 in the supernatant is measured.
2.評価方法
「グルコサミン単独」によるIL-8放出作用、及び「グルコサミン+各種成分」によりIL-8放出作用を下記に示す式から求め、これらの作用から、各種成分併用による「グルコサミン単独」のIL-8放出作用に対する影響(増強または拮抗)を算出した。
(1)「グルコサミン単独」によるIL-8放出作用(%)
A=[「グルコサミン単独」のIL-8濃度/コントロールのIL-8濃度]×100
(2)「グルコサミン+各種成分」によるIL-8放出作用
B=[「グルコサミン+各種成分」のIL-8濃度/コントロールのIL-8濃度]×100
(3)各種成分併用による影響(%)
C=[A/B]×100
2. IL-8 release action by the evaluation method “Glucosamine alone” and IL-8 release action by “Glucosamine + various components” are obtained from the following formulas, and from these actions, “Glucosamine alone” IL- 8 The effect on release action (enhancement or antagonism) was calculated.
(1) IL-8 release action by “glucosamine alone” (%)
A = [IL-8 concentration of “glucosamine alone” / IL-8 concentration of control] × 100
(2) IL-8 release action by “glucosamine + various components” B = [IL-8 concentration of “glucosamine + various components” / IL-8 concentration of control] × 100
(3) Effect of combined use of various components (%)
C = [A / B] × 100
なお、Cが100%を超える場合は、グルコサミンと併用する成分にグルコサミンの抗炎症作用を増強する作用があることを意味し、その超える割合が高いほど、その増強作用も高いと判断することができる。一方、Cが100%を下回る場合は、グルコサミンと併用する成分にグルコサミンの抗炎症作用を拮抗(または減弱)する作用があることを意味し、下回る割合が高いほど、その拮抗(減弱)作用も高いと判断することができる。 In addition, when C exceeds 100%, it means that the component used in combination with glucosamine has an action of enhancing the anti-inflammatory action of glucosamine, and the higher the ratio, the higher the enhancing action can be judged. it can. On the other hand, when C is less than 100%, it means that the component used in combination with glucosamine has an action of antagonizing (or attenuating) the anti-inflammatory action of glucosamine. It can be judged that it is expensive.
3.実験結果
結果を表1及び2に併せて示す。
3. The experimental results are also shown in Tables 1 and 2.
比較例1〜5で使用するヒアルロン酸、オリーブ葉エキス、クルクミン、赤ショウガエキス、及び西洋ヤナギエキスはいずれも抗炎症作用が知られている成分である。表1に示すように、グルコサミンに公知の抗炎症成分を併用しても、グルコサミンの抗炎症作用は増強せず、むしろ効果が拮抗し、減弱することが判明した。一方、メチオニンやシステインなどの含硫アミノ酸、アガロオリゴ糖、及びプロテオグリカンはグルコサミンと併用することで、グルコサミンの抗炎症作用を有意に増強することが判明した。また上記結果から、これらの成分によるグルコサミンの抗炎症作用の増強効果は、含硫アミノ酸によれば、グルコサミン1重量部に対して0.08〜2.5重量部の範囲、特に0.08〜1.2重量部、好ましくは0.08〜0.56重量部、より好ましくは0.08〜0.28重量部の範囲で高いことがわかる。またアガロオリゴ糖によれば、グルコサミン1重量部に対して0.08〜2.5重量部の範囲、特に0.5〜2.5重量部、好ましくは1.0〜2.5重量部、の範囲で高いことがわかる。さらにプロテオグリカンによれば、グルコサミン1重量部に対して0.08〜2.5重量部の範囲、特に0.08〜0.35重量部、好ましくは0.08〜0.2重量部の範囲で高いことがわかる。 Hyaluronic acid, olive leaf extract, curcumin, red ginger extract, and western willow extract used in Comparative Examples 1 to 5 are all components that are known to have anti-inflammatory effects. As shown in Table 1, it was found that even when a known anti-inflammatory component was used in combination with glucosamine, the anti-inflammatory action of glucosamine was not enhanced, but rather the effect was antagonized and attenuated. On the other hand, sulfur-containing amino acids such as methionine and cysteine, agarooligosaccharides, and proteoglycans were found to significantly enhance the anti-inflammatory action of glucosamine when used in combination with glucosamine. Further, from the above results, the effect of enhancing the anti-inflammatory action of glucosamine by these components is in the range of 0.08 to 2.5 parts by weight, particularly 0.08 to 2.5 parts by weight with respect to 1 part by weight of glucosamine, according to the sulfur-containing amino acid. It can be seen that the content is 1.2 parts by weight, preferably 0.08 to 0.56 parts by weight, more preferably 0.08 to 0.28 parts by weight. Moreover, according to agarooligosaccharide, the range of 0.08-2.5 weight part with respect to 1 weight part of glucosamine, especially 0.5-2.5 weight part, Preferably it is 1.0-2.5 weight part. You can see that the range is high. Further, according to proteoglycan, in the range of 0.08 to 2.5 parts by weight, particularly 0.08 to 0.35 parts by weight, preferably 0.08 to 0.2 parts by weight, based on 1 part by weight of glucosamine. I understand that it is expensive.
実施例1〜24
表3及び4に記載する組成からなる錠剤(実施例1〜24)を定法に従って製造した。
Examples 1-24
Tablets (Examples 1 to 24) having the compositions described in Tables 3 and 4 were produced according to a conventional method.
実施例25〜27
表5に記載する組成からなる顆粒剤(実施例25〜27)を定法に従って製造した。
Examples 25-27
Granules (Examples 25 to 27) having the composition described in Table 5 were produced according to a conventional method.
Claims (8)
Priority Applications (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2014223373A JP6736251B2 (en) | 2014-10-31 | 2014-10-31 | Oral composition |
PCT/JP2015/080808 WO2016068317A1 (en) | 2014-10-31 | 2015-10-30 | Oral composition |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2014223373A JP6736251B2 (en) | 2014-10-31 | 2014-10-31 | Oral composition |
Related Child Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2018180583A Division JP2018199728A (en) | 2018-09-26 | 2018-09-26 | Oral composition |
Publications (2)
Publication Number | Publication Date |
---|---|
JP2016088870A true JP2016088870A (en) | 2016-05-23 |
JP6736251B2 JP6736251B2 (en) | 2020-08-05 |
Family
ID=55857650
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2014223373A Active JP6736251B2 (en) | 2014-10-31 | 2014-10-31 | Oral composition |
Country Status (2)
Country | Link |
---|---|
JP (1) | JP6736251B2 (en) |
WO (1) | WO2016068317A1 (en) |
Citations (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5843919A (en) * | 1996-11-25 | 1998-12-01 | Burger; John A. | Composition and method for the treatment of arthritis |
JP2001314173A (en) * | 2000-05-09 | 2001-11-13 | Kyoto Eiyo Kagaku Kenkyusho:Kk | Composition for food |
JP2001327264A (en) * | 2000-05-22 | 2001-11-27 | Reishi Sogo Kenkyusho:Kk | Processed food |
JP2002516866A (en) * | 1998-06-04 | 2002-06-11 | ニュートラマックス ラボラトリーズ,インコーポレイテッド | Amino sugar, glycosaminoglycan and S-adenosylmethionine compositions for treating and repairing connective tissue |
JP2004189685A (en) * | 2002-12-13 | 2004-07-08 | Kyoto Eiyo Kagaku Kenkyusho:Kk | Functional composition for oral administration |
KR20070002401A (en) * | 2005-06-30 | 2007-01-05 | 아미코젠주식회사 | Composition for preventing and treating inflammatory disease comprising glucosamine and pinitol |
JP2007131548A (en) * | 2005-11-08 | 2007-05-31 | Hirosaki Univ | New medicinal use of proteoglycan |
JP2007210993A (en) * | 2005-10-26 | 2007-08-23 | Oriza Yuka Kk | Anti-inflammatory agent |
JP2008120716A (en) * | 2006-11-10 | 2008-05-29 | Eisai Food Chemical Kk | Antiinflammatory agent |
JP2009504662A (en) * | 2005-08-08 | 2009-02-05 | ヒルズ・ペット・ニュートリシャン・インコーポレーテッド | Compositions and methods for use in conditions affected by cartilage |
US20090156666A1 (en) * | 2007-12-11 | 2009-06-18 | Daniel Raederstorff | Novel compositions and use thereof for the treatment, co-treatment or prevention of inflammatory disorders |
JP2012518617A (en) * | 2009-02-23 | 2012-08-16 | ディーエスエム アイピー アセッツ ビー.ブイ. | Cajanus extract and glucosamine for inflammatory diseases |
JP5578384B1 (en) * | 2013-11-15 | 2014-08-27 | 株式会社東洋新薬 | Flavor improving method and flavor improving composition containing N-acetylglucosamine |
-
2014
- 2014-10-31 JP JP2014223373A patent/JP6736251B2/en active Active
-
2015
- 2015-10-30 WO PCT/JP2015/080808 patent/WO2016068317A1/en active Application Filing
Patent Citations (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5843919A (en) * | 1996-11-25 | 1998-12-01 | Burger; John A. | Composition and method for the treatment of arthritis |
JP2002516866A (en) * | 1998-06-04 | 2002-06-11 | ニュートラマックス ラボラトリーズ,インコーポレイテッド | Amino sugar, glycosaminoglycan and S-adenosylmethionine compositions for treating and repairing connective tissue |
JP2001314173A (en) * | 2000-05-09 | 2001-11-13 | Kyoto Eiyo Kagaku Kenkyusho:Kk | Composition for food |
JP2001327264A (en) * | 2000-05-22 | 2001-11-27 | Reishi Sogo Kenkyusho:Kk | Processed food |
JP2004189685A (en) * | 2002-12-13 | 2004-07-08 | Kyoto Eiyo Kagaku Kenkyusho:Kk | Functional composition for oral administration |
KR20070002401A (en) * | 2005-06-30 | 2007-01-05 | 아미코젠주식회사 | Composition for preventing and treating inflammatory disease comprising glucosamine and pinitol |
JP2009504662A (en) * | 2005-08-08 | 2009-02-05 | ヒルズ・ペット・ニュートリシャン・インコーポレーテッド | Compositions and methods for use in conditions affected by cartilage |
JP2007210993A (en) * | 2005-10-26 | 2007-08-23 | Oriza Yuka Kk | Anti-inflammatory agent |
JP2007131548A (en) * | 2005-11-08 | 2007-05-31 | Hirosaki Univ | New medicinal use of proteoglycan |
JP2008120716A (en) * | 2006-11-10 | 2008-05-29 | Eisai Food Chemical Kk | Antiinflammatory agent |
US20090156666A1 (en) * | 2007-12-11 | 2009-06-18 | Daniel Raederstorff | Novel compositions and use thereof for the treatment, co-treatment or prevention of inflammatory disorders |
JP2012518617A (en) * | 2009-02-23 | 2012-08-16 | ディーエスエム アイピー アセッツ ビー.ブイ. | Cajanus extract and glucosamine for inflammatory diseases |
JP5578384B1 (en) * | 2013-11-15 | 2014-08-27 | 株式会社東洋新薬 | Flavor improving method and flavor improving composition containing N-acetylglucosamine |
Non-Patent Citations (6)
Title |
---|
CHIN.J.EXP.SURG., vol. 31, no. 3, JPN6019011716, March 2014 (2014-03-01), pages 616 - 618, ISSN: 0004009773 * |
EXPERIMENTAL AND THERAPEUTIC MEDICINE, vol. 4(4), JPN6018028930, 2012, pages 640 - 644, ISSN: 0003896061 * |
FOOD STYLE 21, vol. 13, no. 1, JPN6018028933, 2009, pages 70 - 72, ISSN: 0004009771 * |
JOURNAL OF IMMUNOLOGY, vol. 166, no. 8, JPN6019011715, 2001, pages 5155 - 5160, ISSN: 0004009772 * |
マイライフ手帳@ニュース, JPN6018028932, 2008, ISSN: 0003896063 * |
第8回グルコサミン研究会学術集会, JPN6018028931, 2012, ISSN: 0003896062 * |
Also Published As
Publication number | Publication date |
---|---|
JP6736251B2 (en) | 2020-08-05 |
WO2016068317A1 (en) | 2016-05-06 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
JP5830030B2 (en) | Low calorie high protein nutritional composition for stimulating muscle protein synthesis | |
CN109222103B (en) | Muscle-building composition and health food | |
US20190008883A1 (en) | Compositions comprising nicotinamide riboside and a urolithin | |
EP1536805A1 (en) | Nutricional compositions comprising a non-glucose carbohydrate or pectin and soluble fiber | |
BR112013000446B1 (en) | use of vitamin d and l-leucine in its free form for the manufacture of a medicament for the prevention and / or treatment of a disease or condition involving muscle wasting in an adult mammal | |
JPWO2013132668A1 (en) | Composition containing imidazole peptide and quercetin glycoside | |
KR102461437B1 (en) | Pharmaceutical composition for preventing or treating obesity having garcinia cambogia extract and health functional food having the same | |
TWI830696B (en) | Compositions for inhibiting muscle fiber degeneration | |
TW201416079A (en) | Therapeutic composition and uses thereof | |
EP1767200A1 (en) | Antiaging agent | |
KR100861430B1 (en) | Preparations and Method of Producing the Same | |
JP2009051833A (en) | Arthralgia-improving composition, and arthralgia improving agent or food | |
JP6270362B2 (en) | Joint pain remedy | |
JP2018199728A (en) | Oral composition | |
JP6736251B2 (en) | Oral composition | |
JP2016210720A (en) | Motor function improving agent, respiratory function improving agent, or cognitive ability improving agent | |
JP5394644B2 (en) | Muscle enhancer containing asperroside or its analog | |
ES2325392B1 (en) | COMPOSITION FOR THE TREATMENT OF ARTROSIS. | |
JP2023542320A (en) | Compositions and methods using xanthan gum to stabilize at least one urolithin in an aqueous matrix | |
Jain et al. | Physiological Determinants of Malnutrition in Elderly | |
KR102563745B1 (en) | Pharmaceutical composition for preventing or treating obesity having garcinia cambogia extract and health functional food having the same | |
CA2939846C (en) | Composition comprising cinnamaldehyde and zinc to improve swallowing | |
WO2022242711A1 (en) | Methods for ameliorating and preventing age‐related muscle degeneration | |
WO2023074893A1 (en) | Cartilage regeneration composition | |
KR101785970B1 (en) | Pharmaceutical composition for the prevention or treatment of muscle loss comprising Oleic acid or pharmaceutically acceptable salts thereof as an active ingredient |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
A711 | Notification of change in applicant |
Free format text: JAPANESE INTERMEDIATE CODE: A711 Effective date: 20150123 |
|
A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A821 Effective date: 20150123 |
|
A621 | Written request for application examination |
Free format text: JAPANESE INTERMEDIATE CODE: A621 Effective date: 20170921 |
|
A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20180731 |
|
A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20180926 |
|
A02 | Decision of refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A02 Effective date: 20181016 |
|
A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A821 Effective date: 20180927 |
|
A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20190115 |
|
A911 | Transfer to examiner for re-examination before appeal (zenchi) |
Free format text: JAPANESE INTERMEDIATE CODE: A911 Effective date: 20190128 |
|
A912 | Re-examination (zenchi) completed and case transferred to appeal board |
Free format text: JAPANESE INTERMEDIATE CODE: A912 Effective date: 20190405 |
|
A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20200410 |
|
A61 | First payment of annual fees (during grant procedure) |
Free format text: JAPANESE INTERMEDIATE CODE: A61 Effective date: 20200715 |
|
R150 | Certificate of patent or registration of utility model |
Ref document number: 6736251 Country of ref document: JP Free format text: JAPANESE INTERMEDIATE CODE: R150 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |