JP2016059564A - X-ray device - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide an X-ray device which can set a region of interest easily and eliminate recognition failure of an object after setting a region of interest.SOLUTION: A blood vessel image Pis acquired as a two-dimensional blood vessel image by performing subtraction of an original image Pbefore contrast medium administration and a peak hold image Pfinally obtained after contrast medium administration by a subtractor 34 prior to fluoroscopy or continuous imaging. The blood vessel image Pacquired by the subtractor 34 is stored in a blood vessel image memory part 35. A first region of interest setting part 36 sets a local region of interest on the basis of the blood vessel image Pstored in the blood vessel image memory part 35. A second region of interest setting part 37 sets regions of interest in a plurality of two-dimensional X-ray images (X-ray images) acquired subsequently with fluoroscopy or continuous imaging. As a result, the regions of interest are easily set and recognition failure of an object after setting the regions of interest can be eliminated.SELECTED DRAWING: Figure 2

Description

  The present invention relates to an X-ray apparatus that acquires a plurality of two-dimensional X-ray images by fluoroscopy or continuous imaging based on detected X-rays, and in particular, performs fluoroscopy or continuous imaging while inserting a device into the body of a subject. Regarding technology.

  Examples of a device inserted into the body of a subject include a stent used for interventional treatment or the like, a marker attached to the stent, and a probe used for intravascular ultrasound (IVUS). When the device is inserted into the body of the subject, feature points of the device are extracted and aligned based on the feature points, so that a plurality of frames of a two-dimensional X-ray image (hereinafter referred to as “X-ray image”) is appropriately used. Highlight the device by overlaying the abbreviations.

  At this time, if the entire image is to be detected, the possibility of erroneous recognition may increase due to an artificial structure such as a clip or a pacemaker existing outside the blood vessel. Therefore, by limiting the entire image to a local region of interest (ROI), specifying the region of interest (ROI) and limiting the device position represented by the marker position, etc., false detection Less results can be obtained (see, for example, Patent Document 1).

Patent Document 1: A technique for setting a region of interest (ROI) by cutting out a partial region from the entire image in addition to the user inputting and setting a region of interest (ROI) as disclosed in JP 2013-215247 A (for example, And a technique for automatically setting a region of interest (ROI) by threshold processing of pixel values of an image (for example, see Patent Document 3).

JP 2013-215247 A JP 2014-4465 A JP 2012-96023 A

However, the conventional example having such a configuration has the following problems.
That is, as disclosed in JP-A-2013-215247, a method of specifying a region of interest (ROI) and detecting a device such as a marker only within the region of interest (ROI) is based on breathing and heartbeat ( There may be a problem that the target device goes out of the region of interest (ROI) due to the heartbeat. In particular, when a device as a target is detected over a plurality of frames by fluoroscopy or continuous shooting, if the target device goes out of the region of interest (ROI), the device is lost at that time.

  Therefore, in Patent Document 2: Japanese Patent Application Laid-Open No. 2014-4465, a device such as a stent appears to be stationary by displaying an X-ray image in synchronization with respiration, heartbeat, and the like. A device that is an object can be detected. However, if fluoroscopy or continuous imaging is performed while moving the catheter wire or the like, the problem that the object such as the catheter wire goes out of the region of interest (ROI) cannot be fundamentally solved. Further, Patent Documents 1 and 2 have a problem that the size and position of the region of interest (ROI) are left to the user's sense and are not convenient.

  Therefore, in Patent Document 3: Japanese Patent Application Laid-Open No. 2012-96023, the size and position of the region of interest (ROI) are set by automatically setting the region of interest (ROI) by the threshold processing of the pixel value of the image as described above. Can be set automatically and simply. However, in Japanese Patent Laid-Open No. 2012-96023, since an image is displayed after reconstruction, there is a problem that it is not suitable for fluoroscopy or continuous imaging while moving a device such as a catheter wire.

  The present invention has been made in view of such circumstances, and it is an object of the present invention to provide an X-ray apparatus capable of easily setting a region of interest and eliminating a recognition failure of an object after the region of interest is set. Objective.

In order to achieve such an object, the present invention has the following configuration.
That is, the X-ray apparatus according to the present invention is an X-ray apparatus that acquires a plurality of two-dimensional X-ray images by fluoroscopy or continuous imaging based on detected X-rays, and a blood vessel image that acquires a two-dimensional blood vessel image An acquisition means, a blood vessel image storage means for storing the two-dimensional blood vessel image acquired by the blood vessel image acquisition means, and a local region of interest based on the two-dimensional blood vessel image stored in the blood vessel image storage means. First region-of-interest setting means for setting, and second region-of-interest for setting a region of interest in the plurality of two-dimensional X-ray images subsequently acquired by fluoroscopy or continuous imaging based on the local region of interest And an area setting means.

  [Operation / Effect] According to the X-ray apparatus of the present invention, the two-dimensional blood vessel image is acquired by the blood vessel image acquiring means. Since the blood vessel image is a two-dimensional image, the two-dimensional blood vessel image can be easily obtained in advance of fluoroscopy or continuous imaging without performing special arithmetic processing (for example, reconstruction processing). The two-dimensional blood vessel image acquired in this way is stored in the blood vessel image storage means, and the first region of interest setting means determines the local region of interest based on the two-dimensional blood vessel image stored in the blood vessel image storage means. Set. Accordingly, the region of interest can be automatically set based on the two-dimensional blood vessel image. On the other hand, the second region-of-interest setting means sets a region of interest in a plurality of two-dimensional X-ray images acquired thereafter through fluoroscopy or continuous imaging. Since the X-ray image is a two-dimensional image, it is almost the same as fluoroscopy or continuous imaging, or simple post-processing (for example, gradation processing or offset correction processing) without performing special arithmetic processing (for example, reconstruction processing). Even in the case of performing the above, the region of interest can be included in the internal information of the two-dimensional X-ray image with a slight time lag from fluoroscopy or continuous imaging, and the user can immediately grasp the region of interest.

  Also, instead of setting a simple figure (for example, a rectangle) as a region of interest as in the prior art, the region of interest is set based on a two-dimensional blood vessel image, so a figure that matches the shape of the blood vessel is set as the region of interest. . When inserting the device into the body of the subject, the device does not jump out of the blood vessel. Therefore, even if the target device is moved by setting the region of interest based on the two-dimensional blood vessel image, the region of interest Never go out and lose sight. As described above, since the region of interest is set based on the two-dimensional blood vessel image, it is not necessary for the user to previously specify the movement range of the device as the region of interest. As a result, it is possible to easily set the region of interest and eliminate the recognition failure of the object after setting the region of interest. In addition, the region of interest can be created in the flow of procedures such as interventional treatment, and the operation can be simplified.

  Further, by having the region of interest in the internal information of the two-dimensional X-ray image, the user may display the region of interest as appropriate or hide it. In the case of displaying the region of interest, the region of interest display means for displaying the region of interest in each two-dimensional X-ray image acquired thereafter by fluoroscopy or continuous imaging by the second region of interest setting means described above is provided. . The display mode of the region of interest display means is not particularly limited, and a frame of the region of interest may be displayed, or the region of interest may be enlarged and displayed in another window.

  In the X-ray apparatus according to these inventions described above, based on the acquired two-dimensional blood vessel image and the pixel value information of the two-dimensional X-ray image acquired thereafter through fluoroscopy or continuous imaging, or It is preferable to include image detection means for detecting an image as either a two-dimensional X-ray image acquired thereafter by fluoroscopy or continuous imaging. In order to accurately perform procedures such as interventional treatment, fluoroscopy for acquiring a plurality of two-dimensional X-ray images immediately after imaging for acquiring a two-dimensional blood vessel image without changing the posture of the subject. Alternatively, continuous shooting is preferably performed continuously. Therefore, by utilizing the fact that the pixel values are different between the two-dimensional blood vessel image and the two-dimensional X-ray image, the pixels of the acquired two-dimensional blood vessel image and the two-dimensional X-ray image acquired thereafter by fluoroscopy or continuous imaging are used. Based on the value information, the image detection means detects an image as either a two-dimensional blood vessel image or a two-dimensional X-ray image acquired thereafter through fluoroscopy or continuous imaging. Thus, based on the pixel value information, a series of imaging can be automatically performed by automatically detecting the acquired image as either a two-dimensional blood vessel image or a two-dimensional X-ray image, The procedure can be performed with high accuracy.

  Of course, an image setting means for performing an input setting for classifying the acquired image into either a two-dimensional blood vessel image or a two-dimensional X-ray image acquired after fluoroscopy or continuous imaging may be provided. An input setting for classifying the acquired image into either a two-dimensional blood vessel image or a two-dimensional X-ray image is manually performed by the user via the image setting unit.

  The two-dimensional blood vessel image in the X-ray apparatus according to these inventions described above is acquired as follows. Based on the two-dimensional X-ray image before contrast medium administration and the two-dimensional X-ray image after contrast medium administration, the blood vessel image acquisition means acquires a two-dimensional blood vessel image. The two-dimensional X-ray image after contrast medium administration includes tissues and artificial structures (such as clips and pacemakers) in addition to blood vessels. By calculating using a two-dimensional X-ray image (also referred to as “original image”) before administration of a contrast agent in which blood vessels do not appear (for example, obtaining a difference), tissue and artificial structures are excluded and only blood vessels are excluded. The image in which is reflected is acquired as a blood vessel image.

Of course, only a two-dimensional X-ray image after contrast medium administration may be acquired as a two-dimensional blood vessel image, and a region of interest may be set based on the two-dimensional blood vessel image (two-dimensional X-ray image after contrast medium administration). . If there is a gap between the pixel value in the blood vessel and the pixel value in the other part, the pixel in the blood vessel can be used even if a tissue or an artificial structure is reflected in the two-dimensional X-ray image after administration of the contrast agent. It is possible to set the region of interest based on the value. For example, when a contrast agent other than CO ₂ is used, the blood vessel appears blackish by administration of the contrast agent, and the pixel value of the blood vessel is lowered. When the artificial structure is a reflector, the artificial structure appears whitish and the pixel value of the artificial structure increases. Therefore, even if an artificial structure or the like is reflected in the two-dimensional X-ray image after administration of the contrast agent, the pixel value in the blood vessel is low, the pixel value in the artificial structure is high, and the pixel value is spaced between the two pixel values. The region of interest can be set based on the pixel value in the blood vessel.

An example of acquiring a two-dimensional blood vessel image based on a two-dimensional X-ray image before contrast agent administration and a two-dimensional X-ray image after contrast agent administration is as follows. That is, blood vessel image acquisition is performed by obtaining a difference between a peak hold image in which the maximum value or minimum value of pixel values in a two-dimensional X-ray image after contrast medium administration is held and a two-dimensional X-ray image before contrast medium administration. The means acquires a two-dimensional blood vessel image. When a contrast medium other than CO ₂ is used, the blood vessel appears dark due to contrast medium administration and the pixel value of the blood vessel decreases, so the minimum pixel value is held in the two-dimensional X-ray image after contrast medium administration. Thus, a peak hold image is obtained by using a pixel (pixel) having a pixel value equal to or less than a threshold value as a blood vessel. Conversely, when a CO ₂ contrast agent is used, the blood vessel appears whitish by administration of the contrast agent and the pixel value of the blood vessel increases, so the maximum pixel value in the two-dimensional X-ray image after contrast agent administration A peak hold image is acquired by holding the pixel (pixel) whose pixel value exceeds the threshold value as a blood vessel. The difference here includes performing subtraction processing after weighting both images, and performing logarithmic conversion of pixel values to perform subtraction processing of values after logarithmic conversion.

  When acquiring a two-dimensional blood vessel image based on a two-dimensional X-ray image before contrast medium administration and a two-dimensional X-ray image after contrast medium administration, the acquired two-dimensional X-ray image before contrast medium administration and contrast Based on the two-dimensional X-ray image after administration of the contrast agent and the pixel value information of the two-dimensional X-ray image acquired thereafter by fluoroscopy or continuous imaging, the two-dimensional X-ray image before administration of the contrast agent, It is preferable to provide an image detecting means for detecting an image as either a two-dimensional X-ray image or a two-dimensional X-ray image acquired thereafter by fluoroscopy or continuous imaging. As described above, in order to perform a technique such as interventional treatment with high accuracy, a two-dimensional blood vessel image (a two-dimensional X-ray image before administration of a contrast agent and a post-contrast agent administration is obtained without changing the posture of the subject. It is preferable to perform fluoroscopy or continuous imaging for acquiring a plurality of two-dimensional X-ray images continuously immediately after imaging for acquiring (two-dimensional X-ray images). Therefore, by using the fact that the pixel values are different between the two-dimensional X-ray image before administration of the contrast agent, the two-dimensional X-ray image after administration of the contrast agent, and the two-dimensional X-ray image, 2 acquired before the contrast agent administration. Based on the two-dimensional X-ray image, the two-dimensional X-ray image after administration of the contrast agent, and the pixel value information of the two-dimensional X-ray image acquired thereafter by fluoroscopy or continuous imaging, the two-dimensional X-ray image before administration of the contrast agent The image detecting means detects an image as a two-dimensional X-ray image after contrast medium administration, or a two-dimensional X-ray image acquired thereafter by fluoroscopy or continuous imaging. Thus, based on the pixel value information, the acquired image is converted into a two-dimensional X-ray image before contrast medium administration, a two-dimensional X-ray image after contrast medium administration, or 2 (obtained thereafter by fluoroscopy or continuous imaging). By automatically detecting an image as a dimensional X-ray image, a series of imaging can be automatically performed, and a procedure can be performed with high accuracy.

  Of course, the acquired image is either a two-dimensional X-ray image before administration of the contrast agent, a two-dimensional X-ray image after administration of the contrast agent, or a two-dimensional X-ray image acquired thereafter by fluoroscopy or continuous imaging. Image setting means for performing input settings for classification may be provided. The acquired image is classified into either a two-dimensional X-ray image before contrast medium administration, a two-dimensional X-ray image after contrast medium administration, or a two-dimensional X-ray image (acquired after fluoroscopy or continuous imaging). The user manually performs input setting via the image setting means.

  According to the X-ray apparatus of the present invention, the blood vessel image acquisition unit acquires a two-dimensional blood vessel image, stores the two-dimensional blood vessel image acquired by the blood vessel acquisition unit in the blood vessel image storage unit, and the blood vessel image storage unit The first region-of-interest setting unit sets a local region of interest based on the two-dimensional blood vessel image stored in (1). Further, the second region-of-interest setting unit sets a region of interest in a plurality of two-dimensional X-ray images acquired thereafter through fluoroscopy or continuous imaging. As a result, it is possible to easily set the region of interest and eliminate the recognition failure of the object after setting the region of interest.

It is a front view of the X-ray apparatus provided with the C arm which concerns on an Example. It is a block diagram of the image processing system in the X-ray apparatus which concerns on an Example. It is a schematic diagram of each image data. (A) And (b) is each display mode of a region-of-interest monitor. It is a flowchart of a series of imaging | photography concerning an Example. It is a side view of the X-ray apparatus which concerns on a modification. It is a block diagram of the image processing system in the X-ray apparatus which concerns on the further modification.

Embodiments of the present invention will be described below with reference to the drawings.
FIG. 1 is a front view of an X-ray apparatus including a C-arm according to the embodiment, FIG. 2 is a block diagram of an image processing system in the apparatus, and FIG. 3 is a schematic diagram of each image data. 4 (a) and 4 (b) are display modes of the region-of-interest monitor. In the block diagram of FIG. 2, the flow of each image data is also shown.

  As shown in FIG. 1, the X-ray apparatus according to the present embodiment performs a top plate 1 on which the subject M is placed and fluoroscopic or continuous imaging of the subject M, or imaging prior to fluoroscopy or continuous imaging. And an image processing system 3 as shown in FIG. As shown in FIG. 1, the top plate 1 is configured to be movable up and down and horizontally.

  First, the video system 2 will be described with reference to FIG. The video system 2 includes a base portion 21 installed on the floor (xy plane in the drawing), a C arm support portion 22 supported by the base portion 21, and a C arm supported by the C arm support portion 22. 23, an X-ray tube 24 supported at one end of the C arm 23, and a flat panel X-ray detector (FPD) 25 supported at the other end. On the X-ray irradiation side of the X-ray tube 24 supported at one end of the C arm 23, a collimator 26 for controlling the irradiation field of X-rays is disposed.

  In addition, a first video system moving unit 27 that rotates the base unit 21 around the vertical axis (z axis in the figure) with respect to the floor surface is provided. The first video system moving unit 27 includes a motor 27a, a belt 27b that transmits the rotation of the motor 27a, a gear box 27c that converts the rotation transmitted to the belt 27b into a rotation around the vertical axis, and a gear box 27c. A gear 27d for transmitting rotation about the vertical axis of the gear 27d, and a gear 27e meshed with the gear 27d. The gear 27e is fixed to the floor surface with a bearing (not shown) interposed. When the motor 27a is rotationally driven, the gear 27e rotates around the vertical axis via the belt 27b, the gear box 27c, and the gear 27d, and the base portion 21 is rotated with respect to the floor surface by the rotation of the gear 27e. Rotates around the vertical axis. Further, when the base portion 21 is rotated around the vertical axis by the first video system moving portion 27, the C arm support portion 22 supported by the base portion 21 is also rotated around the vertical axis, and C The C arm 23 supported by the arm support 22 also rotates around the vertical axis, and the X-ray tube 24 and the flat panel X-ray detector (FPD) 25 supported by the C arm 23 also move around the vertical axis. Rotate and move. As described above, the first video system moving unit 27 rotates the video system 2 around the vertical axis.

  Further, the C-arm support part 22 is rotated around the axis (y-axis in the figure) center perpendicular to the body axis (x-axis in the figure) of the subject M with respect to the body axis (y-axis in the figure) with respect to the base part 21. A two-video system moving unit 28 is provided. The second video system moving unit 28 includes a motor 28a, a belt 28b that transmits the rotation of the motor 28a, and a gear that converts the rotation transmitted to the belt 28b into a rotation around an axis perpendicular to the body axis in a horizontal plane. A box 28c, a gear 28d for transmitting rotation around an axis center orthogonal to the body axis from the gear box 28c in a horizontal plane, and a gear 28e meshed with the gear 28d are provided. The gear 28e is fixed to the base portion 21 with a bearing (not shown) interposed therebetween. When the motor 28a is driven to rotate, the gear 28e rotates around the axis perpendicular to the body axis in the horizontal plane via the belt 28b, the gear box 28c, and the gear 28d. The C-arm support portion 22 rotates relative to the base portion 21 around an axis that is orthogonal to the body axis in a horizontal plane. Further, the C arm 23 supported by the C arm support portion 22 also rotates around an axis that is orthogonal to the body axis in a horizontal plane, and the X-ray tube 24 and the FPD 25 supported by the C arm 23 also move relative to the body axis. And rotate around the axis perpendicular to the horizontal plane. As described above, the second video system moving unit 28 rotates and moves the video system 2 around an axis that is orthogonal to the body axis in a horizontal plane.

  In addition, a third video system moving unit 29 that rotates the C arm 23 around the body axis (x axis in the drawing) of the subject M is provided. The C-arm 23 is formed in a rail shape, and the third video system moving unit 29 includes two bearings 29a fitted in the groove of the C-arm 23 and a belt 29b attached along the outer peripheral surface of the C-arm 23. And a motor 29c that winds a part of the belt 29b. When the motor 29c is driven to rotate, the belt 29b rotates and the C arm 23 slides relative to the bearing 29a. By this sliding, the C arm 23 rotates around the body axis. Further, the X-ray tube 24 and the FPD 25 supported by the C arm 23 also rotate around the body axis. As described above, the third video system moving unit 29 rotates and moves the video system 2 around the body axis.

  As described above, the C-arm 23 that supports the X-ray tube 24 and supports the FPD 25 is formed by being curved in a “C” shape along the direction of rotational movement around the body axis by the third video system moving unit 29. It can be said that the X-ray tube 24 and the FPD 25 rotate around the body axis along the bending direction of the C-arm 23. The second video system moving unit 28 also moves the C arm 23 in the direction of rotational movement around the axis perpendicular to the body axis, which is a direction different from the rotational movement of the C arm 23 around the body axis. It can also be said that the video system 2 is rotated around an axis that is orthogonal to the body axis in a horizontal plane by rotating the image.

  In addition to this, an image that translates the image system 2 in the horizontal direction by translating the base unit 21, the C arm support unit 22, or the C arm 23 in the horizontal direction (for example, the x direction or the y direction in the figure). A system moving part (not shown), an FPD moving part (not shown) for rotating the C arm 23 around a support axis supporting the FPD 25, and the like are provided. In addition, in order to adjust the deflection (positional deviation) due to the weight of the C-arm 23 itself or the X-ray tube 24 or FPD 25 supported by the C-arm 23, an image system adjustment unit (not shown) that rotates and moves in the deflection direction is provided. You may prepare. Moreover, you may provide the image | video system raising / lowering part (illustration omitted) which translates the image | video system 2 along a vertical axis by moving the C arm support part 22 or the C arm 23 up and down along a vertical axis.

  In addition, you may provide the FPD moving part (illustration omitted) which translates FPD25 along the support-axis direction in which C arm 23 supports FPD25. In this case, since the support shaft on which the C-arm 23 supports the FPD 25 is parallel to the perpendicular direction (ie, the irradiation center axis) lowered from the X-ray tube 24 to the FPD 25, the FPD moving portion is along the support shaft direction. By translating the FPD 25, the FPD 25 is translated along the perpendicular direction. In other words, the FPD moving unit changes the distance (ie, SID) at which the perpendicular line is dropped from the X-ray tube 24 to the FPD 25, and the video system 2 is translated in the perpendicular direction.

  The X-ray detection signal obtained by moving the top board 1 and the video system 2 as described above and the FPD 25 detects the X-rays emitted from the X-ray tube 24 is processed by the image processing system 3 described later. Thus, an X-ray image (two-dimensional X-ray image) of the subject M is obtained. In particular, in imaging prior to fluoroscopy or continuous imaging, the X-ray tube 24 and the FPD 25 are installed at desired positions, and the subject M before administration of the contrast medium is placed on the top board 1 to obtain a desired A two-dimensional X-ray image (original image) of the subject M before contrast medium administration is acquired with the subject M set in the posture. Further, a contrast medium is administered without changing the installation position of the X-ray tube 24 and the FPD 25 and the posture of the subject M, and after a lapse of 5 to 20 seconds, a two-dimensional X-ray image of the subject M after the contrast medium is administered. get. A two-dimensional blood vessel image (hereinafter abbreviated as “blood vessel image” as appropriate) is obtained by obtaining a peak hold image from a two-dimensional X-ray image of the subject M after administration of the contrast agent and obtaining a difference between the peak hold image and the original image. get. On the other hand, after acquiring the X-ray image after administration of the contrast agent, a plurality of X-ray images are acquired by fluoroscopy or continuous imaging without changing the installation position of the X-ray tube 24 and the FPD 25 and the posture of the subject M. Each image and image processing based on them will be described in detail later.

Next, the image processing system 3 will be described with reference to FIG. The image processing system 3 includes an image detection unit 31 that detects an X-ray image projected on the detection surface of the FPD 25 based on an X-ray detection signal, an image memory unit 32 that temporarily stores the X-ray image, and a post-contrast agent administration A peak hold 33 for obtaining a peak hold image P ₂ (see also FIG. 3) from a two-dimensional X-ray image, and a subtractor 34 for obtaining a difference between the peak hold image P ₂ and the original image P ₁ (see also FIG. 3); A blood vessel image memory unit 35 that temporarily stores the blood vessel image P ₃ (see also FIG. 3), a first region of interest setting unit 36 that sets a local region of interest ROI (see FIG. 3), and fluoroscopy or continuous imaging A second region-of-interest setting unit 37 that sets a region of interest ROI in a plurality of X-ray images acquired thereafter (through fluoroscopy in this embodiment), and an interest that displays the region of interest ROI in each X-ray image And an area monitor 38. Note that the entire image having the set region of interest ROI is P ₄ (see also FIG. 3). The image detection unit 31 corresponds to the image detection unit in the present invention, the subtractor 34 corresponds to the blood vessel image acquisition unit in the present invention, the blood vessel image memory unit 35 corresponds to the blood vessel image storage unit in the present invention, The first region-of-interest setting unit 36 corresponds to the first region-of-interest setting unit in the present invention, and the second region-of-interest setting unit 37 corresponds to the second region-of-interest setting unit in the present invention. The monitor 38 corresponds to the region of interest display means in this invention.

Based on the pixel value information of the X-ray image acquired by the FPD 25, the image detection unit 31 performs a two-dimensional X-ray image (original image) of the subject M (see FIG. 1) before contrast agent administration, and contrast agent administration. An image is detected as either a two-dimensional X-ray image (finally a peak hold image) of the subject M later or a plurality of X-ray images acquired thereafter through fluoroscopy or continuous imaging (fluoroscopy in this embodiment). To do. Specifically, when a contrast agent other than CO ₂ is used, the blood vessel appears darker by administration of the contrast agent, and the pixel value of the blood vessel decreases. Therefore, the first acquired original image before contrast medium administration has an overall high pixel value, and the second acquired peak hold image after contrast medium administration has an overall low pixel value, so that the contrast medium flows completely. After that, each X-ray image acquired thereafter by fluoroscopy or continuous imaging has an overall high pixel value. Among the images detected by the image detection unit 31 in this way, a plurality of X-ray images acquired thereafter through fluoroscopy are not stored in the image memory unit 32 in order to be displayed on the region of interest monitor 38 in real time. Then, the image is sent to the region of interest monitor 38 via the second region of interest setting unit 37. On the other hand, among the images detected by the image detection unit 31, a two-dimensional X-ray image (original image) before contrast medium administration acquired by fluoroscopic or continuous imaging before the contrast medium administration and two-dimensional X after contrast medium administration The line image is sent to the image memory unit 32.

The original image and the two-dimensional X-ray image after contrast medium administration are written and stored in the image memory unit 32. As shown in FIG. 3, with bleeds through the marker M to be included with the guide wire G and guide wire attached to G stent S and the stent S on the original image P _1, man-made structures such as clips, pacemakers in extravascular C is also reflected. In order to exclude the tissue (not shown) and the artificial structure C, the original image P ₁ stored in the image memory unit 32 is read and sent to the subtractor 34.

On the other hand, the two-dimensional X-ray image after contrast medium administration stored in the image memory unit 32 is read and sent to the peak hold 33. Peak hold 33, and holds the maximum value or the minimum value of pixel values in the two-dimensional X-ray image after contrast administration, to obtain the peak hold image P _2, as shown in FIG. Specifically, when a contrast agent other than CO ₂ is used, the blood vessel appears dark due to the administration of the contrast agent, and the pixel value of the blood vessel becomes low. and holding the minimum value, it obtains the peak hold image P ₂ by the pixel value is below the threshold of a pixel (pixel) and blood vessels. As shown in FIG. 3, the peak hold image P ₂ bleeds through to vessel B is a shadow by the contrast agent. Thus the peak hold image P ₂ obtained by feeding to the subtractor 34.

Subtractor 34, by obtaining the difference between the peak hold image P ₂ to the original image P _1, to obtain the blood vessel image P ₃ as shown in FIG. Specifically, by obtaining a difference for each same pixel in the peak hold image P ₂ and the original image P _1, the tissue to the exclusion of (not shown) or artificial structure C, only the blood vessel B as shown in FIG. 3 acquiring a blood vessel image P ₃ images fancy-through is. Feeding such a blood vessel image P ₃ obtained in the the blood vessel image memory unit 35.

The blood vessel image P ₃ stores written to the blood vessel image memory unit 35. In order to set a local region of interest, the blood vessel image P ₃ stored in the blood vessel image memory unit 35 is read and sent to the first region of interest setting unit 36.

First ROI setting unit 36 sets a region of interest ROI as shown in FIG. 3 based on the blood vessel image P _3. In addition, the setting range of the region of interest ROI is not particularly limited, and only the region recognized as the blood vessel B may be set as the region of interest ROI. The region of interest ROI may be set so as to surround the outside of the blood vessel B. Alternatively, the user may set the range of interest ROI in advance and switch the range of interest ROI according to the contents of the procedure. It is also possible to automatically set the region of interest ROI on the basis of the blood vessel image P _3. For example, the region of interest ROI may be automatically set by performing dilation of the morphology operation on the blood vessel B and obtaining the region after dilation processing as the region of interest ROI. Incidentally, as shown in FIG. 3, the overall image having a set region of interest ROI and P _4. The region of interest ROI set by the first region-of-interest setting unit 36 in this way is sent to the second region-of-interest setting unit 37 at the time of fluoroscopy or continuous imaging (fluoroscopy in this embodiment).

  The second region-of-interest setting unit 37 sets a region of interest ROI in a plurality of X-ray images acquired thereafter through fluoroscopy or continuous imaging (in this example, fluoroscopy). Specifically, in the plurality of X-ray images acquired after fluoroscopy and the region of interest ROI set by the first region-of-interest setting unit 36, the regions of interest ROI are X-rayed by associating each other with the same pixel. Has in the internal information of the image. In the present embodiment, in order to display the region of interest ROI, the second region of interest setting unit 37 sends the region of interest ROI in each X-ray image acquired thereafter through fluoroscopy to the region of interest monitor 38.

  The region of interest ROI in each X-ray image is displayed on the region of interest monitor 38. The display mode of the region of interest monitor 38 is not particularly limited. For example, as shown in FIG. 4A, the frame of the region of interest ROI may be displayed while displaying each X-ray image acquired thereafter through fluoroscopy on the region of interest monitor 38 as a moving image. Further, as shown in FIG. 4B, the region-of-interest monitor 38 is configured by a normal window 38A and another window 38B for enlargement, and each X-ray image acquired thereafter through fluoroscopy in the normal window 38A is displayed. The region of interest ROI may be enlarged and displayed in another window 38B while being displayed as a moving image. Note that there is no particular limitation on the enlargement rate when performing enlarged display. The user may set the enlargement ratio in advance and switch the enlargement ratio according to the contents of the procedure. Further, when displaying in an enlarged manner, as shown in FIG. 4B, the display may be enlarged with the center of the monitor as the center, or may be enlarged with the center of gravity of the region of interest ROI as the center. You may enlarge-display centering on the position of. In particular, when an enlarged display is performed with the position of the device as the center, the device is not lost even if it is enlarged.

  The image detection unit 31, the first region-of-interest setting unit 36, and the second region-of-interest setting unit 37 described above are configured by a central processing unit (CPU) or the like. The image memory unit 32 and the blood vessel image memory unit 35 are configured by a storage medium represented by a RAM (Random-Access Memory) or the like. The peak hold 33 is composed of a peak hold circuit. The subtractor 34 is composed of an operational amplifier and a resistor.

  Next, a series of photographing will be described with reference to FIG. 5 together with FIGS. FIG. 5 is a flowchart of a series of photographing according to the embodiment. In FIG. 5, the X-ray tube 24 (see FIGS. 1 and 2) and the FPD 25 (see FIGS. 1 and 2) are installed at a desired position, and the subject M (FIG. 1 is placed in a desired posture). In this embodiment, the description will be made by taking fluoroscopy as an example.

(Step S1) Imaging before contrast medium administration Imaging of the subject M before contrast medium administration is performed. An image detection unit 31 (see FIG. 2) detects an X-ray image projected on the detection surface of the FPD 25 as a two-dimensional X-ray image (original image) before contrast medium administration. The original image P ₁ (see FIGS. 2 and 3) is written and stored in the image memory unit 32 (see FIG. 2).

(Step S2) Contrast Agent Administration A contrast agent is administered to the subject M. Here, the following will be described assuming that a contrast agent other than CO ₂ is administered.

(Step S3) Imaging after contrast medium administration Imaging of the subject M after contrast medium administration is performed. Imaging is automatically performed 5 seconds to 20 seconds after the contrast medium is administered. Of course, the user may manually perform imaging by pressing an exposure switch (not shown) 5 seconds to 20 seconds after administration of the contrast agent. The image detection unit 31 detects the X-ray image projected on the detection surface of the FPD 25 as a two-dimensional X-ray image after contrast medium administration. As described above, when a contrast agent other than CO ₂ is used, the blood vessel appears dark due to the administration of the contrast agent, and the pixel value of the blood vessel becomes low. Therefore, two-dimensional X-rays after administration of the contrast agent based on the pixel value information What is necessary is just to detect as an image. A two-dimensional X-ray image after contrast medium administration is written and stored in the image memory unit 32.

  The fluoroscopy in step S4 and the acquisition of the peak hold image in step S11, the acquisition of the blood vessel image in step S12, and the setting of the first region of interest in step S13 are performed substantially in parallel. In addition, since the setting of the 2nd region of interest of step S5 mentioned later is performed immediately after step S4, step S11-S13 should just be completed by step S5, and step S11 may be started after step S4. And step S11 may be started before step S4, and step S11 may be started simultaneously with step S4.

(Step S11) Acquisition of Peak Hold Image The two-dimensional X-ray image after contrast medium administration stored in the image memory unit 32 is read and sent to the peak hold 33 (see FIG. 2). The peak hold 33 holds the minimum value of the pixel value in the two-dimensional X-ray image after administration of the contrast agent, and a pixel (pixel) having a pixel value equal to or smaller than a threshold value is used as a blood vessel, whereby the peak hold image P ₂ (FIG. 2). And (see FIG. 3). Feeding such a peak hold image P _2, which is obtained by the subtractor 34 (see Figure 2).

(Step S12) reads the original image P ₁ stored in the acquired image memory unit 32 of the blood vessel image fed to the subtracter 34, the subtracter 34 by calculating a difference between the original image P ₁ and the peak hold image P ₂ The blood vessel image P ₃ (see FIGS. 2 and 3) is acquired. Feeding such a blood vessel image P ₃ obtained in the the blood vessel image memory unit 35 (see Figure 2).

(Step S13) fed to the first region of interest setting unit 36 reads the blood vessel image P ₃ stored in the set blood vessel image memory unit 35 of the first region of interest (see Figure 2), the first ROI setting part 36 sets the region of interest ROI (see FIG. 3) based on the blood vessel image _{P 3.} The region of interest ROI set in this way is sent to the second region of interest setting unit 37 (see FIG. 2).

(Step S4) Perspective On the other hand, in parallel with the acquisition of the peak hold image in Step S11, the acquisition of the blood vessel image in Step S12, and the setting of the first region of interest in Step S13, it is weaker than the imaging in Steps S1 and S3. Perform fluoroscopic irradiation with a dose of X-rays. The fluoroscopy is automatically performed after a predetermined time has elapsed since the imaging after contrast medium administration in step S3. About the predetermined time from imaging | photography after administration of contrast medium of step S3 to the start of fluoroscopy of step S4, a user should just preset the time which contrast agent flows out as the said predetermined time. Of course, the user may manually start the fluoroscopy by pressing a fluoroscopy start switch (not shown) after the contrast medium has flowed out from the imaging after administration of the contrast medium in step S3.

  The image detection unit 31 detects an X-ray image projected on the detection surface of the FPD 25 as an X-ray image obtained by fluoroscopy. As described above, since the pixel value of the X-ray image subsequently acquired by fluoroscopy after the contrast agent has completely flowed out becomes higher as a whole, as the X-ray image acquired by fluoroscopy after that based on the pixel value information What is necessary is just to detect. The X-ray image acquired thereafter by fluoroscopy is displayed in real time on the region of interest monitor 38 (see FIG. 2), and is not stored in the image memory unit 32, but is stored in the second region of interest setting unit 37. To the region of interest monitor 38.

(Step S5) Setting of Second Region of Interest First, the second region of interest setting unit 37 sets the first region of interest in the setting of the first region of interest in step S13 in the X-ray image acquired after the fluoroscopy in step S4. The region of interest ROI set by the region of interest setting unit 37 is set. The region of interest ROI in each X-ray image is sent to the region of interest monitor 38 by the second region of interest setting unit 37.

(Step S6) Display of Region of Interest The region of interest ROI in the X-ray image is displayed on the region of interest monitor 38. As a result, the region of interest ROI set by the second region of interest setting unit 37 in the setting of the second region of interest in step S5 and the X-ray image acquired after the fluoroscopy in step S4 are displayed on the region of interest monitor 38. Display in real time. Note that although the setting of the second region of interest in step S5 is sandwiched between the fluoroscopy in step S4 and the display of the region of interest in step S6, step S5 is not a complicated calculation process. The two regions of interest can be set and the region of interest displayed in step S6 can be displayed almost simultaneously, and the X-ray image acquired after the fluoroscopy in step S4 can be displayed on the region of interest monitor 38 in real time.

(Step S7) A predetermined frame?
Since fluoroscopy is performed over a plurality of frames, the user sets in advance a plurality of frames for fluoroscopy as predetermined frames. Then, it is determined whether or not a predetermined frame has been reached. If the predetermined frame has not been reached, the fluoroscopy is not completed and the process returns to the fluoroscopy in step S4, and steps S4 to S7 are repeated. When the predetermined frame is reached, it is determined that the fluoroscopy is finished, and a series of photographing is finished. In the flowchart of FIG. 5, a fixed predetermined frame is set and fluoroscopy is performed over the set predetermined frame. However, fluoroscopy may be performed over a plurality of frames until the user gives a command to end fluoroscopy. In any case, by repeatedly performing steps S4 to S7, each X-ray image acquired thereafter through fluoroscopy can be displayed as a moving image.

  As in this embodiment, by setting the region of interest ROI based on a two-dimensional blood vessel image (blood vessel image), it is a characteristic part of the present application that a figure that matches the shape of the blood vessel is set as the region of interest ROI. Patent Document 2: Paragraph No. “0034” of Japanese Patent Application Laid-Open No. 2014-4465 discloses that a region with movement is automatically detected, but based on a two-dimensional blood vessel image (blood vessel image) as in the present application. Note that this is not the content of setting the region of interest.

  Further, in Patent Document 3: Japanese Patent Application Laid-Open No. 2012-96023, as described above, the size and position of the region of interest are automatically and simply set by automatically setting the region of interest by threshold processing of the pixel values of the image. Although setting is disclosed, it should be noted that the region of interest is not set based on a two-dimensional blood vessel image (blood vessel image) as in the present application. As described above, in Japanese Patent Laid-Open No. 2012-96023, since an image is displayed after reconstruction, it is not suitable for fluoroscopy or continuous imaging while moving a device such as a catheter wire. Moreover, in patent document 3: Unexamined-Japanese-Patent No. 2012-96023, a region of interest is extracted based on the image (mask image) before contrast agent administration. When extracting a region of interest, a region of interest is extracted by specifying a stent marker by a standard reconstruction filter (first reconstruction filter) and threshold processing, and a two-dimensional blood vessel image (blood vessel image) as in the present application. ) To set the region of interest.

  According to the above-described X-ray apparatus according to the present embodiment, the two-dimensional blood vessel image (blood vessel image) is acquired by the blood vessel image acquisition means (subtractor 34 in this embodiment). Since the blood vessel image is a two-dimensional image, the two-dimensional blood vessel image (blood vessel image) is obtained in advance of fluoroscopy or continuous imaging (fluoroscopy in this embodiment) without performing any special calculation processing (for example, reconstruction processing). It can be obtained easily. The two-dimensional blood vessel image (blood vessel image) acquired in this way is stored in the blood vessel image storage means (the blood vessel image memory unit 35 in this embodiment), and is stored in the blood vessel image storage unit (blood vessel image memory unit 35). Based on the two-dimensional blood vessel image (blood vessel image), a local region of interest ROI is set by the first region of interest setting means (the first region of interest setting unit 36 in this embodiment). Therefore, the region of interest ROI can be automatically set based on the two-dimensional blood vessel image (blood vessel image). On the other hand, the region of interest ROI is converted into a second region of interest setting means (in this embodiment, the second region of interest setting unit 37) in a plurality of two-dimensional X-ray images (X-ray images) acquired thereafter by fluoroscopy or continuous imaging. ) Is set. Since the X-ray image is a two-dimensional image, it is almost the same as fluoroscopy or continuous imaging, or simple post-processing (for example, gradation processing or offset correction processing) without performing special arithmetic processing (for example, reconstruction processing). Even when the operation is performed, the region of interest ROI can be included in the internal information of the two-dimensional X-ray image (X-ray image) with a slight time lag from fluoroscopy or continuous imaging, and the user can immediately grasp the region of interest ROI. .

  Moreover, since a region of interest ROI is set based on a two-dimensional blood vessel image (blood vessel image) instead of setting a simple figure (for example, a rectangle) as the region of interest ROI as in the prior art, a figure that matches the shape of the blood vessel Is set as the region of interest ROI. When the device is inserted into the body of the subject M, the device does not jump out of the blood vessel. Therefore, by setting the region of interest ROI based on the two-dimensional blood vessel image (blood vessel image), the device that is the object is determined. Even if it is moved, it will not go out of the ROI region of interest. As described above, since the region of interest ROI is set based on the two-dimensional blood vessel image (blood vessel image), it is not necessary for the user to previously specify the movement range of the device as the region of interest ROI. As a result, it is possible to easily set the region of interest ROI and eliminate the recognition failure of the object after the region of interest is set. In addition, the region of interest ROI can be created in the flow of procedures such as interventional treatment, and the operation can be simplified.

  In the present embodiment, the region of interest ROI is displayed in the internal information of the two-dimensional X-ray image (X-ray image). When displaying the region of interest ROI, the region of interest ROI in each two-dimensional X-ray image (X-ray image) is displayed by the above-described second region-of-interest setting means (second region-of-interest setting unit 37). A region of interest display means (region of interest monitor 38 in this embodiment) is provided. The display mode of the region of interest display means (region of interest monitor 38) is not particularly limited, and the frame of the region of interest ROI may be displayed as shown in FIG. 4A, or as shown in FIG. Alternatively, the region of interest ROI may be enlarged and displayed in another window 38B.

  In the present embodiment, blood vessel image acquisition means (subtractor) based on a two-dimensional X-ray image (original image) before contrast medium administration and a two-dimensional X-ray image (finally a peak hold image) after contrast medium administration. 34) acquires a two-dimensional blood vessel image (blood vessel image). As shown in FIG. 3, the two-dimensional X-ray image (original image) after administration of the contrast agent also includes tissues and artificial structures C (for example, clips and pacemakers) in addition to blood vessels B. By calculating (subtracting as in this embodiment) using a two-dimensional X-ray image (original image) before administration of the contrast agent in which the blood vessel B does not appear, the tissue and the artificial structure C are excluded, An image including only the blood vessel B is acquired as a blood vessel image.

In particular, in this embodiment, a peak hold image obtained by holding the maximum or minimum pixel value in a two-dimensional X-ray image after administration of a contrast agent and a two-dimensional X-ray image (original image) before administration of the contrast agent are used. By obtaining the difference, the subtractor 34, which is a blood vessel image acquisition means, acquires a two-dimensional blood vessel image (blood vessel image). When a contrast agent other than CO ₂ is used as in the present embodiment, the blood vessel appears darker due to the administration of the contrast agent and the pixel value of the blood vessel becomes lower. Therefore, the pixel value in the two-dimensional X-ray image after administration of the contrast agent A peak hold image is acquired by holding the minimum value of the pixel and setting a pixel (pixel) having a pixel value equal to or less than a threshold value as a blood vessel. Conversely, when a CO ₂ contrast agent is used, the blood vessel appears whitish by administration of the contrast agent and the pixel value of the blood vessel increases, so the maximum pixel value in the two-dimensional X-ray image after contrast agent administration A peak hold image is acquired by holding the pixel (pixel) whose pixel value exceeds the threshold value as a blood vessel.

  The difference in this embodiment is simply subtracted by the subtractor 34 for both images, but is not limited to simple subtraction. Subtraction processing may be performed after weighting both images, or logarithmic conversion of pixel values may be performed to perform subtraction processing of values after logarithmic conversion.

  As in this example, based on the two-dimensional X-ray image (original image) before administration of the contrast agent and the two-dimensional X-ray image (finally the peak hold image) after administration of the contrast agent, a two-dimensional blood vessel image ( In the case of acquiring a blood vessel image), the acquired two-dimensional X-ray image (original image) before administration of the contrast agent, the two-dimensional X-ray image after administration of the contrast agent, and 2 acquired thereafter by fluoroscopy or continuous imaging. Based on the pixel value information of the two-dimensional X-ray image (X-ray image), the two-dimensional X-ray image (original image) before administration of the contrast agent, the two-dimensional X-ray image after administration of the contrast agent, or after fluoroscopy or continuous imaging It is preferable to include image detection means (image detection unit 31 in this embodiment) that detects an image as one of the two-dimensional X-ray images (X-ray images) acquired. In order to perform a technique such as interventional treatment with high accuracy, a two-dimensional blood vessel image (an original image that is a two-dimensional X-ray image before administration of a contrast agent and a post-contrast agent administration in a state in which the posture of the subject M is not changed). It is preferable that fluoroscopy or continuous imaging for acquiring a plurality of two-dimensional X-ray images (X-ray images) is continuously performed immediately after imaging for acquiring (two-dimensional X-ray images). Therefore, a two-dimensional X-ray image (original image) before administration of a contrast agent, a two-dimensional X-ray image after administration of a contrast agent, and a two-dimensional X-ray image (X-ray image acquired thereafter through fluoroscopy or continuous imaging) Taking advantage of the difference in pixel value between the acquired two-dimensional X-ray image (original image) before contrast medium administration, two-dimensional X-ray image after contrast medium administration, and subsequent acquisition by fluoroscopy or continuous imaging Based on the pixel value information of the obtained two-dimensional X-ray image (X-ray image), the two-dimensional X-ray image (original image) before administration of the contrast agent, the two-dimensional X-ray image after administration of the contrast agent, or fluoroscopy or continuous The image detection means (image detection unit 31) detects an image as a two-dimensional X-ray image (X-ray image) acquired after imaging. Thus, based on the pixel value information, the acquired image is acquired as a two-dimensional X-ray image (original image) before contrast agent administration, a two-dimensional X-ray image after contrast agent administration, or (subsequently through fluoroscopy or continuous imaging). By automatically detecting the image as a two-dimensional X-ray image (X-ray image), a series of imaging can be automatically performed, and the procedure can be performed with high accuracy.

  The present invention is not limited to the above-described embodiment, and can be modified as follows.

  (1) In the above-described embodiment, the flat panel X-ray detector is taken as an example of the radiation detection means, but it is normally used as exemplified by the image intensifier (II). Any X-ray detector that detects X-rays is not particularly limited.

(2) The device to be inserted into the body of the subject is not particularly limited. Further, the part into which the device is inserted is not particularly limited. Therefore, the region of interest is not particularly limited, and for example, the brain may be the region of interest. Further, the contrast agent is not particularly limited, and a CO ₂ contrast agent may be used.

  (3) In the above-described embodiment, the X-ray apparatus is provided with the C-arm 23 that rotates and moves the video system 2. However, as shown in FIG. You may apply to the X-ray apparatus which acquires an X-ray image.

  (4) In the above-described embodiment, fluoroscopy is performed to irradiate a dose of X-rays that is weaker than radiography, and a two-dimensional X-ray image (X-ray image) acquired thereafter by fluoroscopy is displayed in real time. Or real-time display. For example, continuous imaging in which X-rays having substantially the same dose as imaging may be performed. In addition, a two-dimensional X-ray image (X-ray image) acquired after fluoroscopy or continuous imaging is temporarily stored in a storage medium such as a RAM, and simple post-processing (for example, gradation processing or offset correction processing) is performed. It may be displayed after each. Even when post-processing is performed, the region of interest can be included in the internal information of the two-dimensional X-ray image (X-ray image) with a slight time lag from fluoroscopy or continuous imaging, and the user can immediately grasp the region of interest. .

  (5) In the above-described embodiment, the region of interest is displayed, but it is not always necessary to display the region of interest. The region of interest may be included in the internal information of the two-dimensional X-ray image (X-ray image), and the user may display the region of interest as appropriate or hide it.

(6) In the above-described embodiment, a two-dimensional blood vessel image based on a two-dimensional X-ray image (original image) before contrast medium administration and a two-dimensional X-ray image (finally a peak hold image) after contrast medium administration. (Blood vessel image) was acquired, but only the two-dimensional X-ray image after contrast medium administration was acquired as a two-dimensional blood vessel image (blood vessel image), and the two-dimensional blood vessel image (two-dimensional X-ray image after contrast agent administration) The region of interest may be set based on If there is a gap between the pixel value in the blood vessel and the pixel value in the other part, the pixel in the blood vessel can be used even if a tissue or an artificial structure is reflected in the two-dimensional X-ray image after administration of the contrast agent. It is possible to set the region of interest based on the value. For example, when a contrast agent other than CO ₂ is used, the blood vessel appears blackish by administration of the contrast agent, and the pixel value of the blood vessel is lowered. When the artificial structure is a reflector, the artificial structure appears whitish and the pixel value of the artificial structure increases. Therefore, even if an artificial structure or the like is reflected in the two-dimensional X-ray image after administration of the contrast agent, the pixel value in the blood vessel is low, the pixel value in the artificial structure is high, and the pixel value is spaced between the two pixel values. The region of interest can be set based on the pixel value in the blood vessel.

  (7) In the above-described embodiment, based on the pixel value information of the acquired image, a two-dimensional X-ray image (original image) before administration of the contrast agent, a two-dimensional X-ray image after administration of the contrast agent, By providing image detection means (an image detection unit 31 in the embodiment) that detects an image as any of the two-dimensional X-ray images (X-ray images) acquired thereafter by continuous imaging, each image is automatically acquired. Although detected, it is not always necessary to detect automatically. As shown in FIG. 7, the acquired image is a two-dimensional X-ray image (original image) before administration of the contrast agent, a two-dimensional X-ray image after administration of the contrast agent, or 2 acquired thereafter by fluoroscopy or continuous imaging. You may provide the input part 41 which performs the input setting classified into either of a dimension X-ray image (X-ray image). The input unit 41 is used to input data and commands input by the user, and is configured by a pointing device represented by a mouse, keyboard, joystick, trackball, touch panel, and the like. In addition, a controller 42 including a central processing unit (CPU) is provided. In order to manually classify each image, the user performs input setting in the input unit 41, and via the controller 42, a two-dimensional X-ray image (original image) before contrast medium administration, and a two-dimensional X-ray after contrast medium administration The acquired image is classified into either an image or a two-dimensional X-ray image (X-ray image) acquired thereafter by fluoroscopy or continuous imaging. By providing this input unit 41, the acquired image is acquired later by a two-dimensional X-ray image (original image) before contrast medium administration, a two-dimensional X-ray image after contrast medium administration, or by fluoroscopy or continuous imaging. The user manually performs an input setting to classify into any of the two-dimensional X-ray images (X-ray images). The input unit 41 corresponds to the image setting means in this invention.

  (8) When only the two-dimensional X-ray image after contrast medium administration is acquired as a two-dimensional blood vessel image (blood vessel image) as in the modification (6) described above, the acquired two-dimensional blood vessel image (blood vessel image) ), And the pixel value information of a two-dimensional X-ray image (X-ray image) acquired thereafter by fluoroscopy or continuous imaging, or subsequently acquired by fluoroscopy or continuous imaging. It is preferable to include an image detection unit 31 (see FIG. 2) that detects an image as one of the two-dimensional X-ray images (X-ray images). In order to perform procedures such as interventional treatment with high accuracy, a plurality of two-dimensional X-ray images (immediately after imaging for acquiring a two-dimensional blood vessel image (blood vessel image) without changing the posture of the subject M ( It is preferable to continuously perform fluoroscopy or continuous imaging for acquiring (X-ray images). Therefore, two-dimensional blood vessel images (blood vessel images) and two-dimensional X-ray images acquired using the fact that pixel values differ between two-dimensional X-ray images (X-ray images acquired after fluoroscopy or continuous imaging). Based on the blood vessel image (blood vessel image) and pixel value information of the two-dimensional X-ray image (X-ray image) acquired thereafter by fluoroscopy or continuous imaging, the two-dimensional blood vessel image (blood vessel image), or fluoroscopy or continuous imaging. Thus, the image detection unit 31 detects an image as one of the two-dimensional X-ray images (X-ray images) acquired thereafter. Thus, based on the pixel value information, the acquired image is either a two-dimensional blood vessel image (blood vessel image) or a two-dimensional X-ray image (X-ray image acquired thereafter by fluoroscopy or continuous imaging). By automatically detecting the image, a series of photographing can be automatically performed, and the procedure can be performed with high accuracy.

  (9) When only the two-dimensional X-ray image after contrast medium administration is acquired as a two-dimensional blood vessel image (blood vessel image) as in the modification (6) described above, a two-dimensional blood vessel image (blood vessel image), or An input unit 41 (see FIG. 7) that performs input settings for classifying the acquired image may be provided in any of the two-dimensional X-ray images (X-ray images) acquired after fluoroscopy or continuous imaging. . The input unit 41 sets input settings for classifying the acquired image into either a two-dimensional blood vessel image (blood vessel image) or a two-dimensional X-ray image (X-ray image acquired thereafter by fluoroscopy or continuous imaging). Via the user manually.

31 ... image detecting unit 34 ... subtractor 35 ... vessel image memory unit 36 ... first ROI setting unit 37 ... second region of interest setting unit 38 ... ROI monitor 41 ... input portion P ₁ ... original image P ₂ ... Peak hold image P ₃ ... Blood vessel image ROI ... Region of interest M ... Subject

Claims (8)

An X-ray apparatus that acquires a plurality of two-dimensional X-ray images by fluoroscopy or continuous imaging based on detected X-rays,
Blood vessel image acquisition means for acquiring a two-dimensional blood vessel image;
Blood vessel image storage means for storing the two-dimensional blood vessel image acquired by the blood vessel image acquisition means;
First region of interest setting means for setting a local region of interest based on the two-dimensional blood vessel image stored in the blood vessel image storage means;
A second region-of-interest setting unit configured to set a region of interest in the plurality of two-dimensional X-ray images acquired subsequently by fluoroscopy or continuous imaging based on the local region of interest. X-ray device. The X-ray apparatus according to claim 1,
An X-ray apparatus characterized in that the blood vessel image acquisition means acquires the two-dimensional blood vessel image based on a two-dimensional X-ray image before contrast medium administration and a two-dimensional X-ray image after contrast agent administration. The X-ray apparatus according to claim 2,
The blood vessel image is obtained by obtaining a difference between a peak hold image in which the maximum value or the minimum value of pixel values in the two-dimensional X-ray image after administration of the contrast agent is held and the two-dimensional X-ray image before administration of the contrast agent. An X-ray apparatus characterized in that the acquisition means acquires the two-dimensional blood vessel image. The X-ray apparatus according to claim 2 or 3,
Based on the acquired two-dimensional X-ray image before administration of the contrast agent, the two-dimensional X-ray image after administration of the contrast agent, and pixel value information of the two-dimensional X-ray image acquired thereafter by fluoroscopy or continuous imaging Thus, an image is detected as one of the two-dimensional X-ray image before administration of the contrast agent, the two-dimensional X-ray image after administration of the contrast agent, or the two-dimensional X-ray image acquired thereafter through fluoroscopy or continuous imaging. An X-ray apparatus comprising image detecting means for performing The X-ray apparatus according to claim 2 or 3,
The acquired image is any one of a two-dimensional X-ray image before administration of the contrast agent, a two-dimensional X-ray image after administration of the contrast agent, or the two-dimensional X-ray image acquired thereafter through fluoroscopy or continuous imaging. An X-ray apparatus comprising image setting means for performing input setting to be classified into The X-ray apparatus according to any one of claims 1 to 5,
An X-ray apparatus comprising: a region-of-interest display unit that displays the region of interest in each of the two-dimensional X-ray images acquired by fluoroscopy or continuous imaging by the second region-of-interest setting unit. . The X-ray apparatus according to claim 1 or 6,
Based on the acquired two-dimensional blood vessel image and the pixel value information of the two-dimensional X-ray image acquired subsequently by fluoroscopy or continuous imaging, the two-dimensional blood vessel image, or acquired subsequently by fluoroscopy or continuous imaging. An X-ray apparatus comprising image detecting means for detecting an image as one of the two-dimensional X-ray images. The X-ray apparatus according to claim 1 or 6,
An image setting means for performing an input setting for classifying the acquired image into either the two-dimensional blood vessel image or the two-dimensional X-ray image acquired thereafter by fluoroscopy or continuous imaging is provided. Wire device.

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