JP2016044176A - Solid composition - Google Patents
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- JP2016044176A JP2016044176A JP2015142888A JP2015142888A JP2016044176A JP 2016044176 A JP2016044176 A JP 2016044176A JP 2015142888 A JP2015142888 A JP 2015142888A JP 2015142888 A JP2015142888 A JP 2015142888A JP 2016044176 A JP2016044176 A JP 2016044176A
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- solid composition
- high amylose
- corn starch
- amylose corn
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- 239000008247 solid mixture Substances 0.000 title claims abstract description 26
- 229920000856 Amylose Polymers 0.000 claims abstract description 32
- 229920002261 Corn starch Polymers 0.000 claims abstract description 31
- 239000008120 corn starch Substances 0.000 claims abstract description 31
- 235000000346 sugar Nutrition 0.000 claims abstract description 10
- SRBFZHDQGSBBOR-IOVATXLUSA-N D-xylopyranose Chemical compound O[C@@H]1COC(O)[C@H](O)[C@H]1O SRBFZHDQGSBBOR-IOVATXLUSA-N 0.000 claims abstract description 8
- PYMYPHUHKUWMLA-UHFFFAOYSA-N arabinose Natural products OCC(O)C(O)C(O)C=O PYMYPHUHKUWMLA-UHFFFAOYSA-N 0.000 claims abstract description 8
- SRBFZHDQGSBBOR-UHFFFAOYSA-N beta-D-Pyranose-Lyxose Natural products OC1COC(O)C(O)C1O SRBFZHDQGSBBOR-UHFFFAOYSA-N 0.000 claims abstract description 8
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims abstract description 6
- 239000008103 glucose Substances 0.000 claims abstract description 6
- 229920001353 Dextrin Polymers 0.000 claims abstract description 5
- 239000004375 Dextrin Substances 0.000 claims abstract description 5
- 235000019425 dextrin Nutrition 0.000 claims abstract description 5
- HDTRYLNUVZCQOY-UHFFFAOYSA-N α-D-glucopyranosyl-α-D-glucopyranoside Natural products OC1C(O)C(O)C(CO)OC1OC1C(O)C(O)C(O)C(CO)O1 HDTRYLNUVZCQOY-UHFFFAOYSA-N 0.000 claims abstract description 4
- OWEGMIWEEQEYGQ-UHFFFAOYSA-N 100676-05-9 Natural products OC1C(O)C(O)C(CO)OC1OCC1C(O)C(O)C(O)C(OC2C(OC(O)C(O)C2O)CO)O1 OWEGMIWEEQEYGQ-UHFFFAOYSA-N 0.000 claims abstract description 4
- GUBGYTABKSRVRQ-XLOQQCSPSA-N Alpha-Lactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-XLOQQCSPSA-N 0.000 claims abstract description 4
- LKDRXBCSQODPBY-JDJSBBGDSA-N D-allulose Chemical compound OCC1(O)OC[C@@H](O)[C@@H](O)[C@H]1O LKDRXBCSQODPBY-JDJSBBGDSA-N 0.000 claims abstract description 4
- HMFHBZSHGGEWLO-SOOFDHNKSA-N D-ribofuranose Chemical compound OC[C@H]1OC(O)[C@H](O)[C@@H]1O HMFHBZSHGGEWLO-SOOFDHNKSA-N 0.000 claims abstract description 4
- 229930091371 Fructose Natural products 0.000 claims abstract description 4
- 239000005715 Fructose Substances 0.000 claims abstract description 4
- RFSUNEUAIZKAJO-ARQDHWQXSA-N Fructose Chemical compound OC[C@H]1O[C@](O)(CO)[C@@H](O)[C@@H]1O RFSUNEUAIZKAJO-ARQDHWQXSA-N 0.000 claims abstract description 4
- AYRXSINWFIIFAE-SCLMCMATSA-N Isomaltose Natural products OC[C@H]1O[C@H](OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C=O)[C@@H](O)[C@@H](O)[C@@H]1O AYRXSINWFIIFAE-SCLMCMATSA-N 0.000 claims abstract description 4
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 claims abstract description 4
- GUBGYTABKSRVRQ-PICCSMPSSA-N Maltose Natural products O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@@H](CO)OC(O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-PICCSMPSSA-N 0.000 claims abstract description 4
- PYMYPHUHKUWMLA-LMVFSUKVSA-N Ribose Natural products OC[C@@H](O)[C@@H](O)[C@@H](O)C=O PYMYPHUHKUWMLA-LMVFSUKVSA-N 0.000 claims abstract description 4
- 229930006000 Sucrose Natural products 0.000 claims abstract description 4
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 claims abstract description 4
- HDTRYLNUVZCQOY-WSWWMNSNSA-N Trehalose Natural products O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@@H](O)[C@@H](CO)O1 HDTRYLNUVZCQOY-WSWWMNSNSA-N 0.000 claims abstract description 4
- HDTRYLNUVZCQOY-LIZSDCNHSA-N alpha,alpha-trehalose Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 HDTRYLNUVZCQOY-LIZSDCNHSA-N 0.000 claims abstract description 4
- HMFHBZSHGGEWLO-UHFFFAOYSA-N alpha-D-Furanose-Ribose Natural products OCC1OC(O)C(O)C1O HMFHBZSHGGEWLO-UHFFFAOYSA-N 0.000 claims abstract description 4
- PYMYPHUHKUWMLA-WDCZJNDASA-N arabinose Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)C=O PYMYPHUHKUWMLA-WDCZJNDASA-N 0.000 claims abstract description 4
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 claims abstract description 4
- GUBGYTABKSRVRQ-QUYVBRFLSA-N beta-maltose Chemical compound OC[C@H]1O[C@H](O[C@H]2[C@H](O)[C@@H](O)[C@H](O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@@H]1O GUBGYTABKSRVRQ-QUYVBRFLSA-N 0.000 claims abstract description 4
- DLRVVLDZNNYCBX-RTPHMHGBSA-N isomaltose Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1OC[C@@H]1[C@@H](O)[C@H](O)[C@@H](O)C(O)O1 DLRVVLDZNNYCBX-RTPHMHGBSA-N 0.000 claims abstract description 4
- 239000008101 lactose Substances 0.000 claims abstract description 4
- 239000005720 sucrose Substances 0.000 claims abstract description 4
- 235000013305 food Nutrition 0.000 claims description 9
- 239000003814 drug Substances 0.000 claims description 8
- 239000000843 powder Substances 0.000 claims description 8
- 239000008187 granular material Substances 0.000 claims description 7
- 229940079593 drug Drugs 0.000 claims description 6
- 239000006187 pill Substances 0.000 claims description 4
- 239000002775 capsule Substances 0.000 claims description 3
- 239000002552 dosage form Substances 0.000 claims description 2
- 229940126701 oral medication Drugs 0.000 claims description 2
- 238000004519 manufacturing process Methods 0.000 abstract description 7
- 239000000203 mixture Substances 0.000 abstract description 7
- 229940099112 cornstarch Drugs 0.000 abstract 4
- MUPFEKGTMRGPLJ-RMMQSMQOSA-N Raffinose Natural products O(C[C@H]1[C@@H](O)[C@H](O)[C@@H](O)[C@@H](O[C@@]2(CO)[C@H](O)[C@@H](O)[C@@H](CO)O2)O1)[C@@H]1[C@H](O)[C@@H](O)[C@@H](O)[C@@H](CO)O1 MUPFEKGTMRGPLJ-RMMQSMQOSA-N 0.000 abstract 1
- MUPFEKGTMRGPLJ-UHFFFAOYSA-N UNPD196149 Natural products OC1C(O)C(CO)OC1(CO)OC1C(O)C(O)C(O)C(COC2C(C(O)C(O)C(CO)O2)O)O1 MUPFEKGTMRGPLJ-UHFFFAOYSA-N 0.000 abstract 1
- MUPFEKGTMRGPLJ-ZQSKZDJDSA-N raffinose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO[C@@H]2[C@@H]([C@@H](O)[C@@H](O)[C@@H](CO)O2)O)O1 MUPFEKGTMRGPLJ-ZQSKZDJDSA-N 0.000 abstract 1
- 238000011156 evaluation Methods 0.000 description 5
- 229920002472 Starch Polymers 0.000 description 4
- 239000003795 chemical substances by application Substances 0.000 description 4
- 230000000052 comparative effect Effects 0.000 description 4
- 239000000047 product Substances 0.000 description 4
- 235000019698 starch Nutrition 0.000 description 4
- 239000008107 starch Substances 0.000 description 4
- 239000013589 supplement Substances 0.000 description 4
- 230000000694 effects Effects 0.000 description 3
- 238000002844 melting Methods 0.000 description 3
- 230000008018 melting Effects 0.000 description 3
- 240000008042 Zea mays Species 0.000 description 2
- 235000005824 Zea mays ssp. parviglumis Nutrition 0.000 description 2
- 235000002017 Zea mays subsp mays Nutrition 0.000 description 2
- 239000008280 blood Substances 0.000 description 2
- 210000004369 blood Anatomy 0.000 description 2
- RYYVLZVUVIJVGH-UHFFFAOYSA-N caffeine Chemical compound CN1C(=O)N(C)C(=O)C2=C1N=CN2C RYYVLZVUVIJVGH-UHFFFAOYSA-N 0.000 description 2
- 239000011248 coating agent Substances 0.000 description 2
- 235000005822 corn Nutrition 0.000 description 2
- 235000015872 dietary supplement Nutrition 0.000 description 2
- 239000004615 ingredient Substances 0.000 description 2
- 239000000314 lubricant Substances 0.000 description 2
- 239000005022 packaging material Substances 0.000 description 2
- XOAAWQZATWQOTB-UHFFFAOYSA-N taurine Chemical compound NCCS(O)(=O)=O XOAAWQZATWQOTB-UHFFFAOYSA-N 0.000 description 2
- MSWZFWKMSRAUBD-IVMDWMLBSA-N 2-amino-2-deoxy-D-glucopyranose Chemical compound N[C@H]1C(O)O[C@H](CO)[C@@H](O)[C@@H]1O MSWZFWKMSRAUBD-IVMDWMLBSA-N 0.000 description 1
- 206010013911 Dysgeusia Diseases 0.000 description 1
- LPHGQDQBBGAPDZ-UHFFFAOYSA-N Isocaffeine Natural products CN1C(=O)N(C)C(=O)C2=C1N(C)C=N2 LPHGQDQBBGAPDZ-UHFFFAOYSA-N 0.000 description 1
- 229920000294 Resistant starch Polymers 0.000 description 1
- 239000000654 additive Substances 0.000 description 1
- 229940024606 amino acid Drugs 0.000 description 1
- 150000001413 amino acids Chemical class 0.000 description 1
- MSWZFWKMSRAUBD-UHFFFAOYSA-N beta-D-galactosamine Natural products NC1C(O)OC(CO)C(O)C1O MSWZFWKMSRAUBD-UHFFFAOYSA-N 0.000 description 1
- 235000008429 bread Nutrition 0.000 description 1
- 238000009395 breeding Methods 0.000 description 1
- 229960001948 caffeine Drugs 0.000 description 1
- VJEONQKOZGKCAK-UHFFFAOYSA-N caffeine Natural products CN1C(=O)N(C)C(=O)C2=C1C=CN2C VJEONQKOZGKCAK-UHFFFAOYSA-N 0.000 description 1
- 235000001465 calcium Nutrition 0.000 description 1
- 150000001720 carbohydrates Chemical class 0.000 description 1
- 239000003086 colorant Substances 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- 235000014510 cooky Nutrition 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 201000006549 dyspepsia Diseases 0.000 description 1
- 239000004088 foaming agent Substances 0.000 description 1
- 235000003599 food sweetener Nutrition 0.000 description 1
- 239000003205 fragrance Substances 0.000 description 1
- 235000013376 functional food Nutrition 0.000 description 1
- 229960002442 glucosamine Drugs 0.000 description 1
- 238000005469 granulation Methods 0.000 description 1
- 230000003179 granulation Effects 0.000 description 1
- 235000013402 health food Nutrition 0.000 description 1
- 241000411851 herbal medicine Species 0.000 description 1
- 230000001771 impaired effect Effects 0.000 description 1
- 230000007413 intestinal health Effects 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- 239000004570 mortar (masonry) Substances 0.000 description 1
- 238000000465 moulding Methods 0.000 description 1
- 230000000291 postprandial effect Effects 0.000 description 1
- 235000021254 resistant starch Nutrition 0.000 description 1
- 210000003296 saliva Anatomy 0.000 description 1
- 230000001953 sensory effect Effects 0.000 description 1
- 239000003381 stabilizer Substances 0.000 description 1
- 238000009495 sugar coating Methods 0.000 description 1
- 150000008163 sugars Chemical class 0.000 description 1
- 239000004094 surface-active agent Substances 0.000 description 1
- 239000003765 sweetening agent Substances 0.000 description 1
- 239000003826 tablet Substances 0.000 description 1
- 229960003080 taurine Drugs 0.000 description 1
- 238000013519 translation Methods 0.000 description 1
- 239000011782 vitamin Substances 0.000 description 1
- 229940088594 vitamin Drugs 0.000 description 1
- 229930003231 vitamin Natural products 0.000 description 1
- 235000013343 vitamin Nutrition 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Landscapes
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
- Grain Derivatives (AREA)
- General Preparation And Processing Of Foods (AREA)
- Jellies, Jams, And Syrups (AREA)
Abstract
Description
本発明は、ハイアミロースコーンスターチを含有する固形組成物に関し、経口の医薬品又は医薬部外品、又は体内に補助的に供給するためのサプリメント等として用いられる食品分野に関するものである。 The present invention relates to a solid composition containing high amylose corn starch, and relates to the field of food used as an oral medicine or quasi-drug, or a supplement for supplementary supply into the body.
ハイアミロースコーンスターチは、消化されにくいアミロースを豊富に含むハイアミロースコーンという品種のトウモロコシから作られたコーンスターチである。ハイアミロースコーンスターチは、オーストラリアにおいて、古典的育種法によって品種改良された
non―GMOの品種である。ハイアミロースコーンスターチは、古くからフライ食品やクッキー、パンなどの食感改良剤や成形剤として用いられており、食品中に少量の配合でその目的が達成されている。
High amylose corn starch is corn starch made from a variety of corn called high amylose corn, which is rich in amylose that is difficult to digest. High amylose corn starch was bred in Australia by classical breeding methods
Non-GMO variety. High amylose corn starch has long been used as a texture improver and molding agent for fried foods, cookies, breads, and the like, and its purpose has been achieved with a small amount of food.
近年、ハイアミロースコーンスターチについて空腹時血糖値維持、食後血糖値上昇抑制、腸健康の維持等の有効性が報告されており、ハイアミロースコーンスターチを効率よく摂取できるよう高濃度で配合した食品、特にサプリメントでの開発が急務である。しかし、ハイアミロースコーンスターチは、口中に含んだ際、唾液を吸うことで口中に貼り付きが生じ、また、口溶けの悪さや特有の粉っぽさを有し、さらには、独特の不快味を呈するため、非常に摂取しづらいものである。よって、ハイアミロースコーンスターチを製品中に高濃度配合しようとする場合は、服用性コンプライアンスの面で改善が必要である。 In recent years, high amylose corn starch has been reported to be effective in maintaining fasting blood glucose level, suppressing postprandial blood glucose level elevation, maintaining intestinal health, etc., and high amylose corn starch is a high-concentration food, especially supplements. There is an urgent need for development. However, high amylose corn starch, when contained in the mouth, sticks in the mouth by sucking saliva, has a poor mouth melting and a peculiar powdery taste, and also exhibits a unique unpleasant taste Therefore, it is very difficult to ingest. Therefore, when high amylose corn starch is to be blended in the product at a high concentration, it is necessary to improve in terms of compliance.
今まで、ハイアミロースコーンスターチを高濃度含む組成物として、特許文献１の健康補助剤が報告されている。しかしながら、ハイアミロースコーンスターチ特有の口溶けの悪さや不快味を解決するものではない。 Until now, the health supplement of patent document 1 has been reported as a composition containing high concentration of high amylose corn starch. However, it does not solve the poor melting and unpleasant taste peculiar to high amylose corn starch.
また、ハイアミロースコーンスターチは流動性が悪いため、ハイアミロースコーンスターチを造粒、打錠又は包材へ充填する場合には、工夫が求められる。 Moreover, since high amylose corn starch has poor fluidity, a device is required for filling high amylose corn starch into granules, tablets, or packaging materials.
上記の問題に鑑み、本発明の目的は、ハイアミロースコーンスターチの服用性を改善した固形組成物を提供することである。あるいは、ハイアミロースコーンスターチを含む組成物を製造する際の作業性を向上することを目的とする。 In view of the above problems, an object of the present invention is to provide a solid composition having improved intake of high amylose corn starch. Or it aims at improving the workability | operativity at the time of manufacturing the composition containing a high amylose corn starch.
本発明者らは上記目的を達成するために鋭意検討した結果、特定の糖、及びデキストリンを配合すると、ハイアミロースコーンスターチの服用性を改善でき、また製造作業性も向上できることを見出し、本発明を完成した。すなわち、本発明は、
（１）（ａ）ハイアミロースコーンスターチ、（ｂ）ラクトース、アラビノース、イソマルトース、キシロース、グルコース、スクロース、粉糖、トレハロース、プシコース、フルクトース、マルトース、リボースからなる群から選ばれる少なくとも１種の糖、及び（ｃ）デキストリンを含有することを特徴とする固形組成物、
（２）食品、経口医薬品又は経口医薬部外品である、（１）に記載の固形組成物、
（３）剤型が、錠剤、チュアブル、丸剤、粉末剤、顆粒剤またはカプセル剤である、（１）又は（２）に記載の固形組成物、
（４）ハイアミロースコーンスターチの含有量が、固形組成物全体に対し３０質量％以上である（１）に記載の固形組成物、
である。
As a result of intensive studies to achieve the above-mentioned object, the present inventors have found that when specific sugars and dextrins are blended, the ingestibility of high amylose corn starch can be improved and the production workability can be improved. completed. That is, the present invention
(1) (a) high amylose corn starch, (b) at least one sugar selected from the group consisting of lactose, arabinose, isomaltose, xylose, glucose, sucrose, powdered sugar, trehalose, psicose, fructose, maltose, ribose, And (c) a solid composition comprising dextrin,
(2) The solid composition according to (1), which is a food, an oral drug, or an oral quasi drug,
(3) The solid composition according to (1) or (2), wherein the dosage form is a tablet, chewable, pill, powder, granule or capsule,
(4) The solid composition according to (1), wherein the content of high amylose corn starch is 30% by mass or more based on the whole solid composition,
It is.
本発明により、服用し易いハイアミロースコーンスターチ含有固形組成物を提供することが可能となった。本発明に係る組成物は、ハイアミロースコーンスターチが高濃度含まれていても、容易に服用可能となった。また、本発明により、ハイアミロースコーンスターチを含有する固形組成物を製造する際の作業効率が向上した。 According to the present invention, it is possible to provide a high amylose corn starch-containing solid composition that is easy to take. The composition according to the present invention can be easily taken even when high concentration of high amylose corn starch is contained. Moreover, the working efficiency at the time of manufacturing the solid composition containing a high amylose corn starch by this invention improved.
本発明で用いるハイアミロースコーンスターチは、RDS(Rapid Degestible Starch、急速に消化されるでん粉)と、SDS(Slow Degestible Starch、ゆっくりと消化されるでん紛)と、RS(Resistant Starch、難性消化性でん紛)を含むものである。本発明のハイアミロースコーンスターチの含有量は、本発明の固形組成物中、３０〜９０質量％が好ましい。より好ましくは３０〜７０質量％以上、最も好ましくは５０〜６０質量％である。 High amylose corn starch used in the present invention is RDS (Rapid Degestible Starch, rapidly digested starch), SDS (Slow Degestible Starch, slowly digested starch) and RS (Resistant Starch, difficult digestion) (Including powdered powder). As for content of the high amylose corn starch of this invention, 30-90 mass% is preferable in the solid composition of this invention. More preferably, it is 30-70 mass% or more, Most preferably, it is 50-60 mass%.
本発明の（ｂ）成分の糖としては、ラクトース、アラビノース、イソマルトース、キシロース、グルコース、スクロース、粉糖、トレハロース、プシコース、フルクトース、マルトース、又はリボースが挙げられる。本発明の（ｂ）成分の糖の含有量は、本発明の固形組成物中、５〜９０質量％が好ましい。 Examples of the sugar of component (b) of the present invention include lactose, arabinose, isomaltose, xylose, glucose, sucrose, powdered sugar, trehalose, psicose, fructose, maltose, or ribose. As for content of the saccharide | sugar of (b) component of this invention, 5-90 mass% is preferable in the solid composition of this invention.
本発明のデキストリンの含有量は、本発明の固形組成物中、１〜６０質量％が好ましい。 The content of the dextrin of the present invention is preferably 1 to 60% by mass in the solid composition of the present invention.
本発明の固形組成物は、食品（特定保健用食品、特別用途食品、機能性食品、健康補助食品（サプリメントを含む）、経口医薬品又は経口医薬部外品など幅広く利用することができる。好ましい剤型としては、錠剤、チュアブル、丸剤、粉末剤、顆粒剤またはカプセル剤などが挙げられる。 The solid composition of the present invention can be widely used for foods (specific health foods, special-purpose foods, functional foods, health supplements (including supplements), oral medicines or oral quasi-drugs. Examples of the mold include tablets, chewables, pills, powders, granules or capsules.
本発明の固形組成物には、本発明の効果を損なわない範囲で、ビタミン類、アミノ酸類、タウリン、グルコサミン、カフェイン、カルシウム類、生薬等の成分を配合することができる。また、必要に応じて上記成分の他に安定化剤、界面活性剤、甘味剤、香料、コーティング剤、糖衣剤、発泡剤、崩壊剤、着色剤、流動化剤、滑沢剤等を配合してもよい。 In the solid composition of the present invention, ingredients such as vitamins, amino acids, taurine, glucosamine, caffeine, calciums, herbal medicines and the like can be blended as long as the effects of the present invention are not impaired. In addition to the above ingredients, stabilizers, surfactants, sweeteners, fragrances, coating agents, sugar-coating agents, foaming agents, disintegrating agents, coloring agents, fluidizing agents, lubricants, etc. may be added as necessary. May be.
本発明の固形組成物の製造方法は、常法により製造することができ、特に限定されるものではない。例えば、本発明の（ａ）成分、（ｂ）成分、（ｃ）成分と、必要に応じて他の成分や公知の添加剤を混合すれば粉末剤が得られる。また、この粉末剤に造粒操作を行えば造粒物（顆粒剤）が得られる。また、前記粉末剤あるいは造粒物に適宜滑沢剤等を加えて打錠すれば、錠剤、チュアブルが得られる。また、前記粉末剤を適当な方法で球状に成形すれば丸剤が得られる。本発明で得られる造粒物(顆粒剤)は流動性が良いので、特に造粒工程含む製法で本発明の固形組成物を製造する場合は、製造効率が一層高まる。
以下に、実施例を示し、本発明を詳細に説明するが、本発明は、下記の例に限定されるものではない。なお、実施例及び比較例の処方において、数値は質量部である。
The manufacturing method of the solid composition of this invention can be manufactured by a conventional method, and is not specifically limited. For example, a powder agent can be obtained by mixing the component (a), component (b), component (c) of the present invention with other components and known additives as necessary. Moreover, if this granule is granulated, a granulated product (granule) can be obtained. In addition, tablets and chewables can be obtained by appropriately adding a lubricant or the like to the powder or granulated product and tableting. A pill can be obtained by forming the powder into a spherical shape by an appropriate method. Since the granulated product (granule) obtained by the present invention has good fluidity, the production efficiency is further enhanced particularly when the solid composition of the present invention is produced by a production method including a granulation step.
Hereinafter, the present invention will be described in detail with reference to examples, but the present invention is not limited to the following examples. In addition, in the prescription of an Example and a comparative example, a numerical value is a mass part.
実施例１〜８、比較例１〜２
下記表１の組み合わせを、水を使用し乳鉢にて造粒し、乾燥後に篩に通し、各組成物を得た。各組成物について、表２の評価基準に従い官能評価し、味、口溶け、粉っぽさを評価した(４名による判定)。評価点が２．５以上で改善効果があると判定した。さらに、分包材等への充填を考慮し、表３の評価基準に従い流動性を目視により評価した(４名による判定)。
Examples 1-8, Comparative Examples 1-2
The combinations shown in Table 1 below were granulated in a mortar using water, passed through a sieve after drying, and each composition was obtained. About each composition, sensory evaluation was performed according to the evaluation criteria of Table 2, and taste, mouth melt, and powderiness were evaluated (judgment by four persons). It was determined that the evaluation score was 2.5 or more and there was an improvement effect. Furthermore, the fluidity was visually evaluated in accordance with the evaluation criteria shown in Table 3 in consideration of filling into the packaging material and the like (judgment by four persons).
実施例１〜８の固形組成物は味、口溶け、粉っぽさが改善され、さらに流動性も良好であった。比較例１においては、全ての評価項目において改善効果が低く、さらに比較例２においては、口溶けは改善できたものの、良好な流動性を得ることができなかった。 The solid compositions of Examples 1 to 8 were improved in taste, melting in the mouth and powder, and also had good fluidity. In Comparative Example 1, the improvement effect was low in all the evaluation items. Further, in Comparative Example 2, although meltability in the mouth could be improved, good fluidity could not be obtained.
本発明により、服用性を改善したハイアミロースコーンスターチ含有固形組成物を得ることが可能となった。よって、ハイアミロースコーンスターチを高濃度含む食品（特にサプリメント）、医薬品又は医薬部外品の分野に有益である。 According to the present invention, it is possible to obtain a high amylose corn starch-containing solid composition having improved dosing properties. Therefore, it is useful in the field of foods (particularly supplements), pharmaceuticals or quasi drugs containing high concentrations of high amylose corn starch.
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| US5562940A (en) * | 1995-03-01 | 1996-10-08 | Kraft Foods, Inc. | Coating mix for simulating chicken skin and method of use |
| JPH09168374A (en) * | 1995-10-16 | 1997-06-30 | Bristol Myers Squibb Co | Nutrition article for diabetes patient with absorption wherein carbohydrate is controlled |
| JPH10195104A (en) * | 1996-12-27 | 1998-07-28 | Nippon Shokuhin Kako Co Ltd | Starch material highly containing dietary fiber, and food and drink, medicine, cosmetic, and industrial product containing the same |
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