JP2016027024A5 - - Google Patents
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- Publication number
- JP2016027024A5 JP2016027024A5 JP2015128359A JP2015128359A JP2016027024A5 JP 2016027024 A5 JP2016027024 A5 JP 2016027024A5 JP 2015128359 A JP2015128359 A JP 2015128359A JP 2015128359 A JP2015128359 A JP 2015128359A JP 2016027024 A5 JP2016027024 A5 JP 2016027024A5
- Authority
- JP
- Japan
- Prior art keywords
- propenamide
- fluorophenyl
- optionally substituted
- medicament according
- oxo
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000003814 drug Substances 0.000 claims 17
- -1 Amino, phenyl Chemical group 0.000 claims 12
- 125000004432 carbon atoms Chemical group C* 0.000 claims 8
- 125000000217 alkyl group Chemical group 0.000 claims 6
- 229910052739 hydrogen Inorganic materials 0.000 claims 5
- 239000001257 hydrogen Substances 0.000 claims 5
- 125000003226 pyrazolyl group Chemical group 0.000 claims 5
- 125000004435 hydrogen atoms Chemical class [H]* 0.000 claims 4
- 125000004043 oxo group Chemical group O=* 0.000 claims 4
- 125000001424 substituent group Chemical group 0.000 claims 4
- 125000005505 thiomorpholino group Chemical group 0.000 claims 4
- 239000004480 active ingredient Substances 0.000 claims 3
- 230000000202 analgesic Effects 0.000 claims 3
- 150000004677 hydrates Chemical class 0.000 claims 3
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 3
- 150000003839 salts Chemical class 0.000 claims 3
- 239000011780 sodium chloride Substances 0.000 claims 3
- 125000001425 triazolyl group Chemical group 0.000 claims 3
- SHNHXYNAUPSFIA-VOTSOKGWSA-N (E)-3-(2-fluorophenyl)-N-(3-thiomorpholin-4-ylpropyl)prop-2-enamide Chemical compound FC1=CC=CC=C1\C=C\C(=O)NCCCN1CCSCC1 SHNHXYNAUPSFIA-VOTSOKGWSA-N 0.000 claims 2
- RMWLEWKISNQIFF-QPJJXVBHSA-N (E)-3-(4-fluorophenyl)-N-(3-thiomorpholin-4-ylpropyl)prop-2-enamide Chemical compound C1=CC(F)=CC=C1\C=C\C(=O)NCCCN1CCSCC1 RMWLEWKISNQIFF-QPJJXVBHSA-N 0.000 claims 2
- FZZJXGCXRNXPHI-QPJJXVBHSA-N (E)-3-(4-fluorophenyl)-N-[3-(1-oxo-1,4-thiazinan-4-yl)propyl]prop-2-enamide Chemical compound C1=CC(F)=CC=C1\C=C\C(=O)NCCCN1CCS(=O)CC1 FZZJXGCXRNXPHI-QPJJXVBHSA-N 0.000 claims 2
- 208000000094 Chronic Pain Diseases 0.000 claims 2
- 208000004296 Neuralgia Diseases 0.000 claims 2
- 208000002193 Pain Diseases 0.000 claims 2
- 150000001875 compounds Chemical class 0.000 claims 2
- 125000000113 cyclohexyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 claims 2
- 229910052731 fluorine Inorganic materials 0.000 claims 2
- 239000011737 fluorine Substances 0.000 claims 2
- 125000003453 indazolyl group Chemical group N1N=C(C2=C1C=CC=C2)* 0.000 claims 2
- 125000000842 isoxazolyl group Chemical group 0.000 claims 2
- 125000004573 morpholin-4-yl group Chemical group N1(CCOCC1)* 0.000 claims 2
- 125000004076 pyridyl group Chemical group 0.000 claims 2
- 125000000719 pyrrolidinyl group Chemical group 0.000 claims 2
- 125000000168 pyrrolyl group Chemical group 0.000 claims 2
- DWPYALMBLPLJGA-BQYQJAHWSA-N (E)-3-(2-fluorophenyl)-N-[3-(4-methylpiperazin-1-yl)propyl]prop-2-enamide Chemical compound C1CN(C)CCN1CCCNC(=O)\C=C\C1=CC=CC=C1F DWPYALMBLPLJGA-BQYQJAHWSA-N 0.000 claims 1
- SACKMYANSABLDL-ZHACJKMWSA-N (E)-N-[2-(4-cyclohexylpiperazin-1-yl)ethyl]-3-(2-fluorophenyl)prop-2-enamide Chemical compound FC1=CC=CC=C1\C=C\C(=O)NCCN1CCN(C2CCCCC2)CC1 SACKMYANSABLDL-ZHACJKMWSA-N 0.000 claims 1
- WJLVFJITMPPACL-VAWYXSNFSA-N (E)-N-[3-(4-cyclohexylpiperazin-1-yl)propyl]-3-(2-fluorophenyl)prop-2-enamide Chemical compound FC1=CC=CC=C1\C=C\C(=O)NCCCN1CCN(C2CCCCC2)CC1 WJLVFJITMPPACL-VAWYXSNFSA-N 0.000 claims 1
- 125000004198 2-fluorophenyl group Chemical group [H]C1=C([H])C(F)=C(*)C([H])=C1[H] 0.000 claims 1
- 208000006820 Arthralgia Diseases 0.000 claims 1
- 208000008035 Back Pain Diseases 0.000 claims 1
- UBAPKYMYWWDANF-UHFFFAOYSA-N FC1=C(C=CC=C1)C(C(=O)NCCCN1CCS(CC1)=O)=C Chemical compound FC1=C(C=CC=C1)C(C(=O)NCCCN1CCS(CC1)=O)=C UBAPKYMYWWDANF-UHFFFAOYSA-N 0.000 claims 1
- 208000008930 Low Back Pain Diseases 0.000 claims 1
- HRPVXLWXLXDGHG-UHFFFAOYSA-N acrylamide Chemical compound NC(=O)C=C HRPVXLWXLXDGHG-UHFFFAOYSA-N 0.000 claims 1
- 125000003545 alkoxy group Chemical group 0.000 claims 1
- 125000005466 alkylenyl group Chemical group 0.000 claims 1
- 125000003785 benzimidazolyl group Chemical group N1=C(NC2=C1C=CC=C2)* 0.000 claims 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 1
- 125000004093 cyano group Chemical group *C#N 0.000 claims 1
- 229940079593 drugs Drugs 0.000 claims 1
- YCKRFDGAMUMZLT-UHFFFAOYSA-N fluorine atom Chemical compound [F] YCKRFDGAMUMZLT-UHFFFAOYSA-N 0.000 claims 1
- 125000001153 fluoro group Chemical group F* 0.000 claims 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 1
- 125000002883 imidazolyl group Chemical group 0.000 claims 1
- 238000002347 injection Methods 0.000 claims 1
- 239000007924 injection Substances 0.000 claims 1
- 125000000587 piperidin-1-yl group Chemical group [H]C1([H])N(*)C([H])([H])C([H])([H])C([H])([H])C1([H])[H] 0.000 claims 1
- 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 claims 1
- 230000001225 therapeutic Effects 0.000 claims 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims 1
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2015128359A JP6313264B2 (ja) | 2014-06-27 | 2015-06-26 | ケイ皮酸アミド誘導体を含有する医薬 |
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2014132060 | 2014-06-27 | ||
JP2014132060 | 2014-06-27 | ||
JP2015128359A JP6313264B2 (ja) | 2014-06-27 | 2015-06-26 | ケイ皮酸アミド誘導体を含有する医薬 |
Publications (3)
Publication Number | Publication Date |
---|---|
JP2016027024A JP2016027024A (ja) | 2016-02-18 |
JP2016027024A5 true JP2016027024A5 (es) | 2017-02-16 |
JP6313264B2 JP6313264B2 (ja) | 2018-04-18 |
Family
ID=55352602
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2015128359A Active JP6313264B2 (ja) | 2014-06-27 | 2015-06-26 | ケイ皮酸アミド誘導体を含有する医薬 |
Country Status (1)
Country | Link |
---|---|
JP (1) | JP6313264B2 (es) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP3497102B1 (de) | 2016-08-15 | 2022-12-07 | Bayer CropScience Aktiengesellschaft | Kondensierte bicyclische heterocyclen-derivate als schädlingsbekämpfungsmittel |
EP3498273A1 (en) * | 2017-12-14 | 2019-06-19 | Universität Wien | Pharmaceutical composition for modulating the response of a gaba-a receptor |
CN112770737B (zh) * | 2018-06-07 | 2024-06-28 | 庆熙大学校产学协力团 | 预防或治疗抗癌药引起的痛觉超敏的药物组合物 |
CN118108655B (zh) * | 2024-04-23 | 2024-06-28 | 四川大学华西医院 | 一类异吲哚啉-1,3-二酮衍生物、其制备方法、其用途和含该衍生物的药物组合物 |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5726266B2 (es) * | 1973-07-17 | 1982-06-03 | ||
JP5210405B2 (ja) * | 2010-03-17 | 2013-06-12 | 日本臓器製薬株式会社 | アミノ酸誘導体を含有する医薬及び該誘導体の製造方法 |
-
2015
- 2015-06-26 JP JP2015128359A patent/JP6313264B2/ja active Active
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