JP2016024044A5

JP2016024044A5 -

Info

Publication number: JP2016024044A5
Application number: JP2014148280A
Authority: JP
Filing date: 2014-07-18
Publication date: 2017-04-27
Anticipated expiration: 2034-07-18

Description

全体制御装置１１５は、自動分析装置を構成する各機構の動作を制御するものであり、外部データ格納部３０７に予め格納された各種設定や各種プログラムに基づいて、検体の分析を行う分析処理や、自動分析装置に生じる振動の種類や程度を判別し、その結果に応じて自動分析装置の状態遷移を制御する振動対応処理（後述）などの動作を制御する。 The overall control device 115 controls the operation of each mechanism constituting the automatic analyzer, and performs analysis processing for analyzing a sample based on various settings and various programs stored in the external data storage unit 307 in advance. The type and degree of vibration generated in the automatic analyzer are discriminated, and the operation of vibration handling processing (described later) for controlling the state transition of the automatic analyzer is controlled according to the result.

光学測定部１３０において、光学測定部１３０の光源ランプ１２０から反応セル２０３に照射された測定光１２０ａは、恒温水２０２に浸漬された反応セル１１２の反応液１１２ａを透過し、分光器１０７の回折格子２０５を経て波長毎に分光され、光検出器２０６によって検出されて、微小な（例えば、小さい場合には数ｐＡの）電気信号に変換される。光検出器２０６での検出信号２０６ａは、全体制御装置１１５の吸光度測定部２０７に送られて、吸光度の測定（比色分析）が行われる。吸光度測定部２０７における測定結果（すなわち吸光度）は、データ格納部１２２に送られて格納される。 In the optical measurement unit 130 , the measurement light 120 a irradiated on the reaction cell 203 from the light source lamp 120 of the optical measurement unit 130 passes through the reaction solution 112 a of the reaction cell 112 immersed in the constant temperature water 202 and is diffracted by the spectroscope 107. The light is dispersed for each wavelength through the grating 205, detected by the photodetector 206, and converted into a minute electric signal (for example, several pA when small). The detection signal 206a from the photodetector 206 is sent to the absorbance measurement unit 207 of the overall control device 115, and absorbance measurement (colorimetric analysis) is performed. The measurement result (that is, the absorbance) in the absorbance measurement unit 207 is sent to the data storage unit 122 and stored therein.

また、自動分析装置を停止させると同時に、反応槽２０１に満たされた恒温水２０２がこぼれることで装置の故障やユーザーの感電等が生じてしまうことを抑制するために、電磁弁２０８ａをオープン状態に固定して、急激に恒温水２０２を排水４０８する（図４のＳ２５０）。この時、恒温水２０２をすべて排水する必要はなく、地震等の振動でもこぼれない程度の液量になるまで排水を行う。なお、停電等により自動分析装置への電源供給が失われた場合において、オープン状態に固定できない電磁弁を使用する場合は、この場合にも排水できるように、ノーマルオープンの電磁弁を使用することも考えられる。ただし、恒温水２０２を排水した状態から、分析可能な状態にするためには、３０分程度の時間を要することがあるため、大型病院のように複数台の分析装置を所有し、例えば災害時においても一部の分析装置は常に分析可能な状態を維持したい場合もあるため、排水しない場合（図４のＳ２４１）が適切な場合もある。従って、排水するか否かについて、オペレータがＵＩ（ユーザーインタフェース３０８）上から設定できるようにする。 Further, in order to prevent the same time stopping the automatic analyzers, electric shock failure or user of the device by a constant temperature water 202 filled in the reaction vessel 201 spilling occurs, open the solenoid valve 208 a The temperature is fixed and the constant temperature water 202 is drained 408 abruptly (S250 in FIG. 4). At this time, it is not necessary to drain all of the constant temperature water 202, and the drainage is performed until the liquid amount becomes a level that does not spill due to vibration such as an earthquake. If the power supply to the automatic analyzer is lost due to a power failure, etc., when using a solenoid valve that cannot be fixed in the open state, use a normally open solenoid valve so that water can be drained in this case as well. Is also possible. However, since it may take about 30 minutes to make the analysis possible from the state in which the constant temperature water 202 is drained, a plurality of analyzers such as a large hospital are owned, for example, in the event of a disaster. However, in some cases, some analyzers may always want to maintain a state in which analysis is possible, and therefore it may be appropriate to not drain (S241 in FIG. 4). Therefore, the operator can set whether to drain from the UI (user interface 308).

本実施の形態の自動分析装置において、振動センサ１２３により振動が検出された場合には、その信号を高速フーリエ変換等により周波数解析処理し、その周波数がどのような周波数帯域にあるかを判定する（図４のＳ１００〜Ｓ１２０）。ここで、自動分析装置に影響を及ぼす種類の振動は大きく２種類ある。一方の振動は、地震などにより自動分析装置に生じる振動で発生する振動で、ユーザーや装置の安全性を害するリスクがある１０Ｈｚ帯域の比較的低い周波数の振動（危険振動）であり、他方の振動は、光検出器２０６から吸光度測定部２０７に微小電流で出力される検出信号２０６ａに影響を及ぼすことで分析結果の信頼性を欠如する可能性がある１００Ｈｚ帯域の振動である。周波数解析処理した振動の信号は、周波数毎の振動の大きさ、すなわち周波数特性であり、特定の周波数成分の振動の大きさを判別可能である。 In the automatic analyzer according to the present embodiment, when vibration is detected by the vibration sensor 123, the signal is subjected to frequency analysis processing by fast Fourier transform or the like to determine what frequency band the frequency is in. (S100 to S120 in FIG. 4). Here, there are two types of vibrations that affect the automatic analyzer. One vibration is a vibration that occurs in an automatic analyzer due to an earthquake or the like, and is a relatively low frequency vibration (dangerous vibration) in the 10 Hz band that has a risk of harming the safety of the user or the device. is the vibration of 100Hz band that may lack the reliability of the analysis result by affecting the detection signal 206a to the absorbance measured tough 207 from the optical detector 206 outputs a minute current. The vibration signal subjected to frequency analysis processing is the magnitude of vibration for each frequency, that is, frequency characteristics, and the magnitude of vibration of a specific frequency component can be determined.

１０１搬送ライン
１０２ローター
１０３試薬ディスク
１０４反応ディスク
１０５ａ検体分注機構
１０５ｂ試薬分注機構
１０６攪拌機構
１０８反応セル洗浄機構
１０９ａ，１０９ｂノズル洗浄機構
１１０検体容器
１１１検体ラック
１１２反応セル
１１２ａ反応液
１１３試薬容器
１１５全体制御装置
１１５ａ電気信号変換部
１１５ｂ比較部
１１５ｃ制御部
１１６ａ，１１６ｂノズル
１２０光源ランプ
１２０ａ測定光
１２１検体分注位置
１２２データ格納部
１３０光学測定部
１５０カバー部
２０１反応槽
２０２恒温水
２０６光検出器
２０７吸光度測定部
２０８排水路
２０８ａ電磁弁
２０９建物排水設備
３０７外部データ格納部
３０８ユーザーインタフェース 101 transportation line 102 rotor 103 reagent disk 104 reaction disk 105a specimen dispensing Organization 105b reagent dispensing mechanism 106 stirring mechanism 108 reaction cell cleaning mechanism 109a, 109b nozzle cleaning mechanism 110 sample container 111 the sample rack 112 reaction cells 112a reaction 113 reagent Container 115 Overall control device 115a Electric signal conversion unit 115b Comparison unit 115c Control unit 116a, 116b Nozzle 120 Light source lamp 120a Measurement light 121 Sample dispensing position 122 Data storage unit 130 Optical measurement unit 150 Cover unit 201 Reaction tank 202 Constant temperature water 206 Light Detector 207 Absorbance measurement unit 208 Drainage channel 208a Solenoid valve 209 Building drainage equipment 307 External data storage unit 308 User interface

Claims

A sample container containing a sample to be analyzed, a reagent container containing a reagent, a reaction cell for mixing and reacting the sample and the reagent, and dispensing the sample from the sample container to the reaction cell Automatic equipped with a sample dispensing mechanism, a reagent dispensing mechanism for dispensing the reagent from the reagent container to the reaction cell, and an analysis unit for analyzing a mixed solution of the sample and the reagent contained in the reaction cell In the analyzer
A vibration detector for detecting vibrations of the automatic analyzer;
A frequency analysis unit for performing frequency analysis of vibration detected by the vibration detection unit;
Based on the analysis result by the frequency analysis unit, a vibration factor determination unit that determines the generation factor of the vibration,
An automatic analyzer comprising: a control unit that controls state transition of the automatic analyzer based on a determination result in a vibration factor determination unit.

The automatic analyzer according to claim 1, wherein
The vibration factor determination unit determines the generation factor of the vibration based on at least one of the frequency, acceleration, and duration of the vibration based on the analysis result of the frequency analysis unit. Analysis equipment.

The automatic analyzer according to claim 1, wherein
The vibration factor determination unit, when the frequency of the vibration based on the analysis result of the frequency analysis unit is in a predetermined earthquake determination range as a frequency range of vibration due to an earthquake, the vibration factor is an earthquake Automatic analyzer characterized by judgment.

The automatic analyzer according to claim 1, wherein
The vibration factor determination unit is based on the analysis result of the frequency analysis unit, and the frequency of the vibration based on the analysis result of the frequency analysis unit is in a predetermined earthquake determination range as a frequency range of vibration caused by an earthquake. An automatic analyzer characterized by determining that the factor of vibration is an earthquake when the vibration acceleration is within an influence acceleration determination range predetermined as an acceleration range that adversely affects the automatic analyzer.

The automatic analyzer according to claim 3 or 4,
The automatic analysis apparatus, wherein the earthquake determination range includes a frequency of at least 10 Hz.

The automatic analyzer according to claim 1, wherein
In the vibration factor determination unit, the frequency of the vibration based on the analysis result of the frequency analysis unit is in a predetermined analysis influence determination range as a vibration frequency range that is a vibration other than an earthquake and adversely affects the analysis result. In this case, the automatic analyzer is characterized in that it is determined that the factor of the vibration is an analysis influence vibration.

The automatic analyzer according to claim 1, wherein
The vibration factor determination unit is in an analysis influence determination range that is predetermined as a frequency range of vibrations based on the analysis result of the frequency analysis unit that is a vibration other than an earthquake and adversely affects the analysis result. And, when the acceleration of the vibration based on the analysis result of the frequency analysis unit is a vibration other than an earthquake and is in a predetermined analysis influence determination range as a vibration acceleration range that affects the analysis result, An automatic analyzer characterized by determining that a vibration factor is analysis-affected vibration.

The automatic analyzer according to claim 6 or 7,
The automatic analysis apparatus, wherein the analysis influence determination range includes a frequency of at least 100 Hz.

The automatic analyzer according to claim 1, wherein
The control unit includes an operation stop of the automatic analyzer as a state transition of the automatic analyzer based on a determination result in the vibration factor determination unit.

The automatic analyzer according to claim 1, wherein
A cover part that covers at least the movable part of the automatic analyzer and restricts the user's access to the movable part;
Wherein the control unit is configured as a state transition determination based on a result the automatic analyzer by the vibration factor determination unit, an automatic analyzer which comprises a fixation in a closed state the cover of the automatic analyzer.

The automatic analyzer according to claim 1, wherein
The control unit includes a stop of power supply to a movable part in the automatic analyzer as a state transition of the automatic analyzer based on a determination result in the vibration factor determination unit.

The automatic analyzer according to claim 1, wherein
The automatic analysis device, wherein the control unit includes drainage of liquid in the automatic analysis device as a state transition of the automatic analysis device based on a determination result in the vibration factor determination unit.

The automatic analyzer according to claim 1, wherein
The control unit determines the reliability of the analysis result obtained by the analysis unit based on the analysis result by the frequency analysis unit.

The automatic analyzer according to claim 1, wherein
The said control part has a function which controls the state transition of the said automatic analyzer based on the earthquake motion generation | occurrence | production information which alert | reports beforehand the arrival of the shake by the occurrence of an earthquake.