JP2015537000A5 - - Google Patents

Info

Publication number

JP2015537000A5

JP2015537000A5 JP2015542037A JP2015542037A JP2015537000A5 JP 2015537000 A5 JP2015537000 A5 JP 2015537000A5 JP 2015542037 A JP2015542037 A JP 2015542037A JP 2015542037 A JP2015542037 A JP 2015542037A JP 2015537000 A5 JP2015537000 A5 JP 2015537000A5

Authority

JP

Japan

Prior art keywords

pharmaceutical composition

calcium

receptor

ligand

flux agonist

Prior art date

2013-11-13

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
• Global Dossier
• Discuss

• 239000008194 pharmaceutical composition Substances 0.000 claims 22
• 239000000556 agonist Substances 0.000 claims 20
• 230000003185 calcium uptake Effects 0.000 claims 20
• 239000003446 ligand Substances 0.000 claims 13
• 230000028993 immune response Effects 0.000 claims 8
• 210000003491 skin Anatomy 0.000 claims 8
• 102000007863 pattern recognition receptors Human genes 0.000 claims 7
• 108010089193 pattern recognition receptors Proteins 0.000 claims 7
• 101000936911 Chionoecetes opilio Sarcoplasmic/endoplasmic reticulum calcium ATPase Proteins 0.000 claims 6
• 239000003710 calcium ionophore Substances 0.000 claims 6
• CJAONIOAQZUHPN-KKLWWLSJSA-N ethyl 12-[[2-[(2r,3r)-3-[2-[(12-ethoxy-12-oxododecyl)-methylamino]-2-oxoethoxy]butan-2-yl]oxyacetyl]-methylamino]dodecanoate Chemical group CCOC(=O)CCCCCCCCCCCN(C)C(=O)CO[C@H](C)[C@@H](C)OCC(=O)N(C)CCCCCCCCCCCC(=O)OCC CJAONIOAQZUHPN-KKLWWLSJSA-N 0.000 claims 6
• 239000003112 inhibitor Substances 0.000 claims 6
• 102000005962 receptors Human genes 0.000 claims 6
• 108020003175 receptors Proteins 0.000 claims 6
• HIYAVKIYRIFSCZ-CVXKHCKVSA-N Calcimycin Chemical compound CC([C@H]1OC2([C@@H](C[C@H]1C)C)O[C@H]([C@H](CC2)C)CC=1OC2=CC=C(C(=C2N=1)C(O)=O)NC)C(=O)C1=CC=CN1 HIYAVKIYRIFSCZ-CVXKHCKVSA-N 0.000 claims 3
• HATRDXDCPOXQJX-UHFFFAOYSA-N Thapsigargin Natural products CCCCCCCC(=O)OC1C(OC(O)C(=C/C)C)C(=C2C3OC(=O)C(C)(O)C3(O)C(CC(C)(OC(=O)C)C12)OC(=O)CCC)C HATRDXDCPOXQJX-UHFFFAOYSA-N 0.000 claims 3
• 206010052428 Wound Diseases 0.000 claims 3
• 208000027418 Wounds and injury Diseases 0.000 claims 3
• 244000052616 bacterial pathogen Species 0.000 claims 3
• HIYAVKIYRIFSCZ-UHFFFAOYSA-N calcium ionophore A23187 Natural products N=1C2=C(C(O)=O)C(NC)=CC=C2OC=1CC(C(CC1)C)OC1(C(CC1C)C)OC1C(C)C(=O)C1=CC=CN1 HIYAVKIYRIFSCZ-UHFFFAOYSA-N 0.000 claims 3
• PGHMRUGBZOYCAA-ADZNBVRBSA-N ionomycin Chemical group O1[C@H](C[C@H](O)[C@H](C)[C@H](O)[C@H](C)/C=C/C[C@@H](C)C[C@@H](C)C(/O)=C/C(=O)[C@@H](C)C[C@@H](C)C[C@@H](CCC(O)=O)C)CC[C@@]1(C)[C@@H]1O[C@](C)([C@@H](C)O)CC1 PGHMRUGBZOYCAA-ADZNBVRBSA-N 0.000 claims 3
• PGHMRUGBZOYCAA-UHFFFAOYSA-N ionomycin Natural products O1C(CC(O)C(C)C(O)C(C)C=CCC(C)CC(C)C(O)=CC(=O)C(C)CC(C)CC(CCC(O)=O)C)CCC1(C)C1OC(C)(C(C)O)CC1 PGHMRUGBZOYCAA-UHFFFAOYSA-N 0.000 claims 3
• IXFPJGBNCFXKPI-FSIHEZPISA-N thapsigargin Chemical compound CCCC(=O)O[C@H]1C[C@](C)(OC(C)=O)[C@H]2[C@H](OC(=O)CCCCCCC)[C@@H](OC(=O)C(\C)=C/C)C(C)=C2[C@@H]2OC(=O)[C@@](C)(O)[C@]21O IXFPJGBNCFXKPI-FSIHEZPISA-N 0.000 claims 3
• JZODKRWQWUWGCD-UHFFFAOYSA-N 2,5-di-tert-butylbenzene-1,4-diol Chemical group CC(C)(C)C1=CC(O)=C(C(C)(C)C)C=C1O JZODKRWQWUWGCD-UHFFFAOYSA-N 0.000 claims 2
• CLLKVTAGSOWKHA-UHFFFAOYSA-N 2-[2-(dicyclohexylamino)-2-oxoethoxy]-n,n-dioctadecylacetamide Chemical compound C1CCCCC1N(C(=O)COCC(=O)N(CCCCCCCCCCCCCCCCCC)CCCCCCCCCCCCCCCCCC)C1CCCCC1 CLLKVTAGSOWKHA-UHFFFAOYSA-N 0.000 claims 2
• CNZIQHGDUXRUJS-UHFFFAOYSA-N Cyclopiazonic acid Natural products CC(=C/1C(=O)C2C3C(Cc4cccc5[nH]cc3c45)C(C)(C)N2C1=O)O CNZIQHGDUXRUJS-UHFFFAOYSA-N 0.000 claims 2
• 102000003945 NF-kappa B Human genes 0.000 claims 2
• 108010057466 NF-kappa B Proteins 0.000 claims 2
• 102000018546 Paxillin Human genes 0.000 claims 2
• ACNHBCIZLNNLRS-UHFFFAOYSA-N Paxilline 1 Natural products N1C2=CC=CC=C2C2=C1C1(C)C3(C)CCC4OC(C(C)(O)C)C(=O)C=C4C3(O)CCC1C2 ACNHBCIZLNNLRS-UHFFFAOYSA-N 0.000 claims 2
• 108700031954 Tgfb1i1/Leupaxin/TGFB1I1 Proteins 0.000 claims 2
• CNZIQHGDUXRUJS-DQYPLSBCSA-N alpha-cyclopiazonic acid Natural products CC(O)=C1C(=O)[C@@H]2[C@@H]3[C@@H](Cc4cccc5[nH]cc3c45)C(C)(C)N2C1=O CNZIQHGDUXRUJS-DQYPLSBCSA-N 0.000 claims 2
• GOOXRYWLNNXLFL-UHFFFAOYSA-H azane oxygen(2-) ruthenium(3+) ruthenium(4+) hexachloride Chemical compound N.N.N.N.N.N.N.N.N.N.N.N.N.N.[O--].[O--].[Cl-].[Cl-].[Cl-].[Cl-].[Cl-].[Cl-].[Ru+3].[Ru+3].[Ru+4] GOOXRYWLNNXLFL-UHFFFAOYSA-H 0.000 claims 2
• ZKSIPEYIAHUPNM-ZEQRLZLVSA-N butobendine Chemical compound C([C@H](CC)N(C)CCN(C)[C@@H](CC)COC(=O)C=1C=C(OC)C(OC)=C(OC)C=1)OC(=O)C1=CC(OC)=C(OC)C(OC)=C1 ZKSIPEYIAHUPNM-ZEQRLZLVSA-N 0.000 claims 2
• JTLQADIQVNKIFC-UHFFFAOYSA-N calcium ionophore vi Chemical compound C=1C(C(C)(C)C)=CC=2CC(C=3OCCP(=O)(C=4C=CC=CC=4)C=4C=CC=CC=4)=CC(C(C)(C)C)=CC=3CC(C=3OCCP(=O)(C=4C=CC=CC=4)C=4C=CC=CC=4)=CC(C(C)(C)C)=CC=3CC(C=3OCCP(=O)(C=4C=CC=CC=4)C=4C=CC=CC=4)=CC(C(C)(C)C)=CC=3CC=1C=2OCCP(=O)(C=1C=CC=CC=1)C1=CC=CC=C1 JTLQADIQVNKIFC-UHFFFAOYSA-N 0.000 claims 2
• 239000003814 drug Substances 0.000 claims 2
• 230000000694 effects Effects 0.000 claims 2
• 230000002708 enhancing effect Effects 0.000 claims 2
• NLDDIKRKFXEWBK-AWEZNQCLSA-N gingerol Chemical compound CCCCC[C@H](O)CC(=O)CCC1=CC=C(O)C(OC)=C1 NLDDIKRKFXEWBK-AWEZNQCLSA-N 0.000 claims 2
• JZLXEKNVCWMYHI-UHFFFAOYSA-N gingerol Natural products CCCCC(O)CC(=O)CCC1=CC=C(O)C(OC)=C1 JZLXEKNVCWMYHI-UHFFFAOYSA-N 0.000 claims 2
• 235000002780 gingerol Nutrition 0.000 claims 2
• 238000004519 manufacturing process Methods 0.000 claims 2
• URAUKAJXWWFQSU-UHFFFAOYSA-N n,n-dicyclohexyl-2-[2-(dicyclohexylamino)-2-oxoethoxy]acetamide Chemical compound C1CCCCC1N(C1CCCCC1)C(=O)COCC(=O)N(C1CCCCC1)C1CCCCC1 URAUKAJXWWFQSU-UHFFFAOYSA-N 0.000 claims 2
• LKKJODPUVIMZGC-UHFFFAOYSA-N n-octadecyl-2-[2-[19-[2-[2-(octadecylamino)-2-oxoethoxy]acetyl]-1,4,7,13,16-pentaoxa-10,19-diazacyclohenicos-10-yl]-2-oxoethoxy]acetamide Chemical compound CCCCCCCCCCCCCCCCCCNC(=O)COCC(=O)N1CCOCCOCCOCCN(C(=O)COCC(=O)NCCCCCCCCCCCCCCCCCC)CCOCCOCC1 LKKJODPUVIMZGC-UHFFFAOYSA-N 0.000 claims 2
• ACNHBCIZLNNLRS-UBGQALKQSA-N paxilline Chemical compound N1C2=CC=CC=C2C2=C1[C@]1(C)[C@@]3(C)CC[C@@H]4O[C@H](C(C)(O)C)C(=O)C=C4[C@]3(O)CC[C@H]1C2 ACNHBCIZLNNLRS-UBGQALKQSA-N 0.000 claims 2
• 230000011664 signaling Effects 0.000 claims 2
• 230000000699 topical effect Effects 0.000 claims 2
• 102100032814 ATP-dependent zinc metalloprotease YME1L1 Human genes 0.000 claims 1
• 102000004890 Interleukin-8 Human genes 0.000 claims 1
• 108090001007 Interleukin-8 Proteins 0.000 claims 1
• 101800000795 Proadrenomedullin N-20 terminal peptide Proteins 0.000 claims 1
• 206010072170 Skin wound Diseases 0.000 claims 1
• 230000004913 activation Effects 0.000 claims 1
• 230000001413 cellular effect Effects 0.000 claims 1
• 210000004207 dermis Anatomy 0.000 claims 1
• 229940079593 drug Drugs 0.000 claims 1
• 239000003937 drug carrier Substances 0.000 claims 1
• 210000002615 epidermis Anatomy 0.000 claims 1
• 238000009472 formulation Methods 0.000 claims 1
• 239000000203 mixture Substances 0.000 claims 1
• PIRWNASAJNPKHT-SHZATDIYSA-N pamp Chemical group C([C@@H](C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(N)=N)C(N)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](C)N)C(C)C)C1=CC=CC=C1 PIRWNASAJNPKHT-SHZATDIYSA-N 0.000 claims 1
• 230000028327 secretion Effects 0.000 claims 1
• 239000007787 solid Substances 0.000 claims 1
• 230000029663 wound healing Effects 0.000 claims 1