JP2015534850A - 脊椎固定を促進するためのインスリン−疑似局所治療補助剤 - Google Patents

脊椎固定を促進するためのインスリン−疑似局所治療補助剤 Download PDF

Info

Publication number
JP2015534850A
JP2015534850A JP2015539859A JP2015539859A JP2015534850A JP 2015534850 A JP2015534850 A JP 2015534850A JP 2015539859 A JP2015539859 A JP 2015539859A JP 2015539859 A JP2015539859 A JP 2015539859A JP 2015534850 A JP2015534850 A JP 2015534850A
Authority
JP
Japan
Prior art keywords
insulin
mimetic
bone tissue
bone
zinc
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2015539859A
Other languages
English (en)
Japanese (ja)
Other versions
JP2015534850A5 (https=
Inventor
リン，シェルドン，ストン
コーナー，ジョン．
ヴィヴェス，マイケル，ジェイ．
ベネヴェニア，ジョセフ
ブレイトバート，エリック
Original Assignee
ラトガース，ザ ステート ユニバーシティ オブ ニュー ジャージー
ラトガース，ザ ステート ユニバーシティ オブ ニュー ジャージー
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ラトガース，ザ ステート ユニバーシティ オブ ニュー ジャージー, ラトガース，ザ ステート ユニバーシティ オブ ニュー ジャージー filed Critical ラトガース，ザ ステート ユニバーシティ オブ ニュー ジャージー
Publication of JP2015534850A publication Critical patent/JP2015534850A/ja
Publication of JP2015534850A5 publication Critical patent/JP2015534850A5/ja
Pending legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/24—Heavy metals; Compounds thereof
    • A61K33/30—Zinc; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/04—Sulfur, selenium or tellurium; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/24—Heavy metals; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/46—Ingredients of undetermined constitution or reaction products thereof, e.g. skin, bone, milk, cotton fibre, eggshell, oxgall or plant extracts
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/28—Materials for coating prostheses
    • A61L27/30—Inorganic materials
    • A61L27/306—Other specific inorganic materials not covered by A61L27/303 - A61L27/32
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/54—Biologically active materials, e.g. therapeutic substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A61F2/44—Joints for the spine, e.g. vertebrae, spinal discs
    • A61F2/4455—Joints for the spine, e.g. vertebrae, spinal discs for the fusion of spinal bodies, e.g. intervertebral fusion of adjacent spinal bodies, e.g. fusion cages
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A61F2002/30001—Additional features of subject-matter classified in A61F2/28, A61F2/30 and subgroups thereof
    • A61F2002/30667—Features concerning an interaction with the environment or a particular use of the prosthesis
    • A61F2002/30677—Means for introducing or releasing pharmaceutical products, e.g. antibiotics, into the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2310/00—Prostheses classified in A61F2/28 or A61F2/30 - A61F2/44 being constructed from or coated with a particular material
    • A61F2310/00005—The prosthesis being constructed from a particular material
    • A61F2310/00179—Ceramics or ceramic-like structures
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2310/00—Prostheses classified in A61F2/28 or A61F2/30 - A61F2/44 being constructed from or coated with a particular material
    • A61F2310/00005—The prosthesis being constructed from a particular material
    • A61F2310/00179—Ceramics or ceramic-like structures
    • A61F2310/00293—Ceramics or ceramic-like structures containing a phosphorus-containing compound, e.g. apatite
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2310/00—Prostheses classified in A61F2/28 or A61F2/30 - A61F2/44 being constructed from or coated with a particular material
    • A61F2310/00005—The prosthesis being constructed from a particular material
    • A61F2310/00359—Bone or bony tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2310/00—Prostheses classified in A61F2/28 or A61F2/30 - A61F2/44 being constructed from or coated with a particular material
    • A61F2310/00389—The prosthesis being coated or covered with a particular material
    • A61F2310/0097—Coating or prosthesis-covering structure made of pharmaceutical products, e.g. antibiotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/32—Bones; Osteocytes; Osteoblasts; Tendons; Tenocytes; Teeth; Odontoblasts; Cartilage; Chondrocytes; Synovial membrane
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/10—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing inorganic materials
    • A61L2300/102—Metals or metal compounds, e.g. salts such as bicarbonates, carbonates, oxides, zeolites, silicates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2430/00—Materials or treatment for tissue regeneration
    • A61L2430/38—Materials or treatment for tissue regeneration for reconstruction of the spine, vertebrae or intervertebral discs

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Inorganic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Transplantation (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Dermatology (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Botany (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Surgical Instruments (AREA)
  • Materials For Medical Uses (AREA)
JP2015539859A 2012-10-25 2013-10-25 脊椎固定を促進するためのインスリン−疑似局所治療補助剤 Pending JP2015534850A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261718646P 2012-10-25 2012-10-25
US61/718,646 2012-10-25
PCT/US2013/066895 WO2014066808A1 (en) 2012-10-25 2013-10-25 Insulin-mimetic local therapeutic adjuncts for enhancing spinal fusion

Publications (2)

Publication Number Publication Date
JP2015534850A true JP2015534850A (ja) 2015-12-07
JP2015534850A5 JP2015534850A5 (https=) 2016-12-15

Family

ID=50545335

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2015539859A Pending JP2015534850A (ja) 2012-10-25 2013-10-25 脊椎固定を促進するためのインスリン−疑似局所治療補助剤

Country Status (6)

Country Link
US (1) US20150004249A1 (https=)
EP (1) EP2911614A4 (https=)
JP (1) JP2015534850A (https=)
AU (1) AU2013334111A1 (https=)
CA (1) CA2889519A1 (https=)
WO (1) WO2014066808A1 (https=)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US12419978B2 (en) 2016-02-09 2025-09-23 Rutgers, The State University Of New Jersey Antimicrobial composition for inhibiting microbial organisms in allograft and the method thereof
US12178205B2 (en) 2016-02-09 2024-12-31 Rutgers, The State University Of New Jersey Systems and methods for storing and preserving implantable devices
EP3988092B1 (en) * 2019-06-24 2026-01-28 Shenzhen Fangshengtai Medical Technology Co., Ltd. Oxovanadium complexes for use in the treatment of pain

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1511595A (zh) * 2002-12-31 2004-07-14 华中科技大学同济医学院附属协和医院 骨组织填充材料
WO2012079024A2 (en) * 2010-12-10 2012-06-14 University Of Medicine And Dentistry Of New Jersey Implantable devices coated with insulin-mimetic agent composites and methods thereof
JP2015502938A (ja) * 2011-11-29 2015-01-29 ユニバーシティ オブ メディスン アンド デンティストリー オブ ニュー ジャージー 骨再生のための治療補助薬としてのインスリン−疑似剤

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4834757A (en) * 1987-01-22 1989-05-30 Brantigan John W Prosthetic implant
US5614206A (en) * 1995-03-07 1997-03-25 Wright Medical Technology, Inc. Controlled dissolution pellet containing calcium sulfate
EP1335686B1 (en) * 2000-10-24 2008-12-17 Warsaw Orthopedic, Inc. Spinal fusion devices
US7291179B2 (en) * 2002-06-24 2007-11-06 Wright Medical Technology, Inc. Bone graft substitute composition
EP1594423B1 (en) * 2003-02-14 2009-01-07 DePuy Spine, Inc. In-situ formed intervertebral fusion device
US9199005B2 (en) * 2003-10-01 2015-12-01 New York University Calcium phosphate-based materials containing zinc, magnesium, fluoride and carbonate
US7419680B2 (en) * 2003-10-01 2008-09-02 New York University Calcium phosphate-based materials containing zinc, magnesium, fluoride and carbonate
US7189409B2 (en) * 2004-03-09 2007-03-13 Inion Ltd. Bone grafting material, method and implant
US20090220566A1 (en) * 2006-02-01 2009-09-03 Jake Barralet Bioimplants for use in tissue growth
WO2009114535A2 (en) * 2008-03-10 2009-09-17 Marfly 2, Lp Bone paste composition
WO2010114827A1 (en) * 2009-04-01 2010-10-07 Difusion Technologies, Inc. Regulation of bone growth using zeolite in combination with bone graft substitutes
BR112012017535A2 (pt) * 2010-01-15 2019-09-24 Of Medicine And Dentistry Of New Jersey University uso de compostos de vanádio para cicatrização de osso

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1511595A (zh) * 2002-12-31 2004-07-14 华中科技大学同济医学院附属协和医院 骨组织填充材料
WO2012079024A2 (en) * 2010-12-10 2012-06-14 University Of Medicine And Dentistry Of New Jersey Implantable devices coated with insulin-mimetic agent composites and methods thereof
JP2015502938A (ja) * 2011-11-29 2015-01-29 ユニバーシティ オブ メディスン アンド デンティストリー オブ ニュー ジャージー 骨再生のための治療補助薬としてのインスリン−疑似剤

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
ADACHI, Y., ET AL., BIOMED RES TRACE ELEMENTS, vol. 15, no. 4, JPN6016032922, 2004, pages 351 - 4, ISSN: 0003756441 *
BAQUER, N.Z., ET AL., J BIOSCI, vol. 28, no. 2, JPN6016032926, 2003, pages 215 - 21, ISSN: 0003756442 *
BAQUER, N.Z., ET AL., J BIOSCI, vol. 36, no. 2, JPN6016032928, June 2011 (2011-06-01), pages 383 - 96, ISSN: 0003756444 *
NEUROSURGERY, vol. 39, no. 3, JPN6017031432, 1996, pages 548 - 554, ISSN: 0003756445 *
SUBASINGHE, S., ET AL., BIOCHEM MED, vol. 34, no. 1, JPN6016032927, 1985, pages 83 - 92, ISSN: 0003756443 *

Also Published As

Publication number Publication date
AU2013334111A1 (en) 2015-05-28
US20150004249A1 (en) 2015-01-01
CA2889519A1 (en) 2014-05-01
EP2911614A4 (en) 2016-04-13
WO2014066808A1 (en) 2014-05-01
EP2911614A1 (en) 2015-09-02

Similar Documents

Publication Publication Date Title
EP0608313B1 (en) Formulations of blood clot-polymer matrix for delivery of osteogenic proteins
JP5878477B2 (ja) 骨の治癒を加速するためのバナジウム化合物の使用
US7763582B2 (en) Localized insulin delivery for bone healing
JP6214548B2 (ja) 骨再生のための治療補助薬としてのインスリン−疑似剤
US11596712B2 (en) Autologous bone graft substitute composition
US9999636B2 (en) Insulin-mimetics as therapeutic adjuncts for bone regeneration
US20150004249A1 (en) Insulin-mimetic local therapeutic adjuncts for enhancing spinal fusion
US20170035803A1 (en) Insulin-mimetic local therapeutic adjuncts for enhancing spinal fusion
US9931348B2 (en) Vanadium compounds as therapeutic adjuncts for cartilage injury and repair
AU2011205741B2 (en) Use of vanadium compounds to accelerate bone healing
US20180318344A1 (en) Zinc or manganese compounds as therapeutic adjuncts for cartilage regeneration and repair
HK1178799B (en) Use of vanadium compounds to accelerate bone healing

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20150821

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20161024

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20161024

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20170822

A02 Decision of refusal

Free format text: JAPANESE INTERMEDIATE CODE: A02

Effective date: 20180313