JP2015524821A - システイン変異及びμ尾部を介して多量体化した抗体又は融合タンパク質 - Google Patents

システイン変異及びμ尾部を介して多量体化した抗体又は融合タンパク質 Download PDF

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JP2015524821A
JP2015524821A JP2015525568A JP2015525568A JP2015524821A JP 2015524821 A JP2015524821 A JP 2015524821A JP 2015525568 A JP2015525568 A JP 2015525568A JP 2015525568 A JP2015525568 A JP 2015525568A JP 2015524821 A JP2015524821 A JP 2015524821A
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antibody
fusion protein
region
μtp
antibodies
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JP2015524821A5 (enExample
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ナオヤ ツルシタ，
ナオヤ ツルシタ，
ジェイ． ユン ツォ，
ジェイ． ユン ツォ，
Original Assignee
ジェイエヌ バイオサイエンシーズ エルエルシー
ジェイエヌ バイオサイエンシーズ エルエルシー
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Publication of JP2015524821A publication Critical patent/JP2015524821A/ja
Publication of JP2015524821A5 publication Critical patent/JP2015524821A5/ja
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2878—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/35—Valency
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C07K2317/524—CH2 domain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C07K2317/526—CH3 domain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/75—Agonist effect on antigen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Microbiology (AREA)
  • Biomedical Technology (AREA)
  • Oncology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
JP2015525568A 2012-08-02 2013-07-31 システイン変異及びμ尾部を介して多量体化した抗体又は融合タンパク質 Withdrawn JP2015524821A (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201261679045P 2012-08-02 2012-08-02
US61/679,045 2012-08-02
US201361767724P 2013-02-21 2013-02-21
US61/767,724 2013-02-21
PCT/US2013/053086 WO2014022592A1 (en) 2012-08-02 2013-07-31 Antibodies or fusion proteins multimerized via cysteine mutation and a mu tailpiece

Publications (2)

Publication Number Publication Date
JP2015524821A true JP2015524821A (ja) 2015-08-27
JP2015524821A5 JP2015524821A5 (enExample) 2016-08-25

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JP2015525568A Withdrawn JP2015524821A (ja) 2012-08-02 2013-07-31 システイン変異及びμ尾部を介して多量体化した抗体又は融合タンパク質

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US (1) US9540442B2 (enExample)
EP (1) EP2880057A4 (enExample)
JP (1) JP2015524821A (enExample)
CN (1) CN104684928A (enExample)
CA (1) CA2879814A1 (enExample)
IN (1) IN2015DN01361A (enExample)
WO (1) WO2014022592A1 (enExample)

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JP2018538283A (ja) * 2015-11-30 2018-12-27 ファイザー・インク 部位特異的コンジュゲーションのための抗体および抗体断片
JP2024535710A (ja) * 2021-08-27 2024-10-02 サンシャイン・グオジアン・ファーマシューティカル（シャンハイ）カンパニー・リミテッド Ｃｄｃプラットホーム抗体

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JP2018538283A (ja) * 2015-11-30 2018-12-27 ファイザー・インク 部位特異的コンジュゲーションのための抗体および抗体断片
JP2024535710A (ja) * 2021-08-27 2024-10-02 サンシャイン・グオジアン・ファーマシューティカル（シャンハイ）カンパニー・リミテッド Ｃｄｃプラットホーム抗体
JP7735545B2 (ja) 2021-08-27 2025-09-08 サンシャイン・グオジアン・ファーマシューティカル（シャンハイ）カンパニー・リミテッド Ｃｄｃプラットホーム抗体

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CN104684928A (zh) 2015-06-03
US20140037621A1 (en) 2014-02-06
US9540442B2 (en) 2017-01-10
EP2880057A1 (en) 2015-06-10
IN2015DN01361A (enExample) 2015-07-03
WO2014022592A1 (en) 2014-02-06
CA2879814A1 (en) 2014-02-06
EP2880057A4 (en) 2016-03-23

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