JP2015511963A - Ｔｏｒキナーゼ阻害剤を用いた癌の治療 - Google Patents

Ｔｏｒキナーゼ阻害剤を用いた癌の治療 Download PDF

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Publication number
JP2015511963A
JP2015511963A JP2015500593A JP2015500593A JP2015511963A JP 2015511963 A JP2015511963 A JP 2015511963A JP 2015500593 A JP2015500593 A JP 2015500593A JP 2015500593 A JP2015500593 A JP 2015500593A JP 2015511963 A JP2015511963 A JP 2015511963A
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JP
Japan
Prior art keywords
substituted
unsubstituted
pyrazin
breast cancer
tor kinase
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JP2015500593A
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English (en)
Japanese (ja)
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JP2015511963A5 (enExample
Inventor
シュ，スイチャン
ヘゲ，クリステン，マエ
レイモン，ヘザー
ナーラ，ラマ，ケイ．
Original Assignee
シグナル ファーマシューティカルズ，エルエルシー
シグナル ファーマシューティカルズ，エルエルシー
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Publication of JP2015511963A publication Critical patent/JP2015511963A/ja
Publication of JP2015511963A5 publication Critical patent/JP2015511963A5/ja
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/14—Drugs for genital or sexual disorders; Contraceptives for lactation disorders, e.g. galactorrhoea
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Endocrinology (AREA)
  • Pregnancy & Childbirth (AREA)
  • Reproductive Health (AREA)
  • Gynecology & Obstetrics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
JP2015500593A 2012-03-15 2013-03-14 Ｔｏｒキナーゼ阻害剤を用いた癌の治療 Pending JP2015511963A (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201261611374P 2012-03-15 2012-03-15
US61/611,374 2012-03-15
US201261715331P 2012-10-18 2012-10-18
US61/715,331 2012-10-18
PCT/US2013/031185 WO2013138553A1 (en) 2012-03-15 2013-03-14 Treatment of cancer with tor kinase inhibitors

Related Child Applications (1)

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JP2017218014A Division JP6470820B2 (ja) 2012-03-15 2017-11-13 Ｔｏｒキナーゼ阻害剤を用いた癌の治療

Publications (2)

Publication Number Publication Date
JP2015511963A true JP2015511963A (ja) 2015-04-23
JP2015511963A5 JP2015511963A5 (enExample) 2016-04-21

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JP2015500593A Pending JP2015511963A (ja) 2012-03-15 2013-03-14 Ｔｏｒキナーゼ阻害剤を用いた癌の治療
JP2017218014A Active JP6470820B2 (ja) 2012-03-15 2017-11-13 Ｔｏｒキナーゼ阻害剤を用いた癌の治療

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JP2017218014A Active JP6470820B2 (ja) 2012-03-15 2017-11-13 Ｔｏｒキナーゼ阻害剤を用いた癌の治療

Country Status (19)

Country Link
US (2) US20130245027A1 (enExample)
EP (1) EP2825169B1 (enExample)
JP (2) JP2015511963A (enExample)
KR (1) KR102057359B1 (enExample)
CN (1) CN104271139A (enExample)
AU (1) AU2013202993B2 (enExample)
BR (1) BR112014022707A2 (enExample)
CA (1) CA2867348A1 (enExample)
ES (1) ES2678250T3 (enExample)
IL (1) IL234641B (enExample)
MX (1) MX360880B (enExample)
MY (1) MY178012A (enExample)
NI (1) NI201400112A (enExample)
NZ (1) NZ628407A (enExample)
PH (1) PH12014502046B1 (enExample)
SG (1) SG11201405724RA (enExample)
TW (1) TWI635862B (enExample)
WO (1) WO2013138553A1 (enExample)
ZA (1) ZA201406701B (enExample)

Families Citing this family (15)

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AU2013203714B2 (en) 2012-10-18 2015-12-03 Signal Pharmaceuticals, Llc Inhibition of phosphorylation of PRAS40, GSK3-beta or P70S6K1 as a marker for TOR kinase inhibitory activity
MX374749B (es) * 2013-04-17 2025-03-06 Signal Pharm Llc Terapia de combinacion que comprende un inhibidor de tor cinasa y un analogo de citidina para tratar cancer.
EP2986322A1 (en) 2013-04-17 2016-02-24 Signal Pharmaceuticals, LLC Combination therapy comprising a tor kinase inhibitor and a 5-substituted quinazolinone compound for treating cancer
NZ629332A (en) 2013-04-17 2017-05-26 Signal Pharm Llc Treatment of cancer with dihydropyrazino-pyrazines
NZ629411A (en) 2013-04-17 2017-06-30 Signal Pharm Llc Treatment of cancer with dihydropyrazino-pyrazines
NZ629230A (en) 2013-04-17 2017-05-26 Signal Pharm Llc Pharmaceutical formulations, processes, solid forms and methods of use relating to 1-ethyl-7-(2-methyl-6-(1h-1,2,4-triazol-3-yl)pyridin-3-yl)-3,4-dihydropyrazino[2,3-b]pyrazin-2(1h)-one
CA2909579A1 (en) 2013-04-17 2014-10-23 Signal Pharmaceuticals, Llc Combination therapy comprising a tor kinase inhibitor and n-(3-(5-fluoro-2-(4-(2-methoxyethoxy)phenylamino)pyrimidin-4-ylamino)phenyl)acrylamide for treating cancer
NZ629469A (en) 2013-04-17 2017-05-26 Signal Pharm Llc Methods for treating cancer using dihydropyrazino-pyrazine compound combination therapy
HK1223286A1 (zh) 2013-05-29 2017-07-28 西格诺药品有限公司 7-(6-(2-羟基丙-2-基)吡啶-3-基)-1-((反式)-4-甲氧基环己基)-3，4-二氢吡嗪并[2，3-b]吡嗪-2(1h)-酮的药物组合物、其固体形式及它们的使用方法
NZ714742A (en) 2014-04-16 2017-04-28 Signal Pharm Llc Solid forms of 1-ethyl-7-(2-methyl-6-(1h-1,2,4-triazol-3-yl)pyridin-3-yl)-3,4-dihydropyrazino[2,3-b]pyrazin-2(1h)-one, compositions thereof and methods of their use
EP3131551A4 (en) 2014-04-16 2017-09-20 Signal Pharmaceuticals, LLC SOLID FORMS COMPRISING 1-ETHYL-7-(2-METHYL-6-(1H-1,2,4-TRIAZOL-3-YL) PYRIDIN-3-YL)-3,4-DIHYDROPYRAZINO(2,3-b)PYRAZIN-2(1H)-ONE, AND A COFORMER, COMPOSITIONS AND METHODS OF USE THEREOF
WO2015160868A1 (en) 2014-04-16 2015-10-22 Signal Pharmaceuticals, Llc Methods for treating cancer using tor kinase inhibitor combination therapy
WO2015160882A1 (en) 2014-04-16 2015-10-22 Signal Pharmaceuticals, Llc SOLID FORMS COMPRISING 7-(6-(2-HYDROXYPROPAN-2YL) PYRIDIN-3-YL)-1-(TRANS)-4-METHOXYCYCLOHEXYL)-3, 4-DIHYDROPYRAZINO[2,3-b] PYRAZIN-2(1H)-ONE, AND A COFORMER, COMPOSITIONS AND METHODS OF USE THEREOF
MY198676A (en) 2017-06-22 2023-09-15 Celgene Corp Treatment of hepatocellular carcinoma characterized by hepatitis b virus infection
CN112933088B (zh) * 2021-02-03 2022-02-22 南华大学附属第一医院 Y041-5921在制备抗肿瘤药物中的应用

Citations (1)

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Publication number Priority date Publication date Assignee Title
WO2010062571A1 (en) * 2008-10-27 2010-06-03 Signal Pharmaceuticals, Llc Mtor kinase inhibitors for oncology indications and diseases associated with the mtor/p13k/akt pathway

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ZA200902384B (en) 2006-10-19 2010-07-28 Signal Pharm Llc Heteroaryl compounds, compositions thereof, and use thereof as protein kinase inhibitors
CN105693730A (zh) * 2006-10-19 2016-06-22 西格诺药品有限公司 杂芳基化合物、其组合物以及它们作为蛋白激酶抑制剂的用途
AU2009234259A1 (en) * 2008-04-11 2009-10-15 Bionovo, Inc. Anticancer methods employing extracts of Gleditsia sinensis Lam
EP2320894B1 (en) * 2008-08-20 2016-12-28 The United States of America, as represented by the Secretary, Department of Health and Human Services Chemoprevention of head and neck squamous cell carcinomas
CA2778615C (en) 2009-10-26 2019-04-23 Signal Pharmaceuticals, Llc Methods of synthesis and purification of heteroaryl compounds

Patent Citations (1)

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Publication number Priority date Publication date Assignee Title
WO2010062571A1 (en) * 2008-10-27 2010-06-03 Signal Pharmaceuticals, Llc Mtor kinase inhibitors for oncology indications and diseases associated with the mtor/p13k/akt pathway

Non-Patent Citations (8)

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Title
BERK L, ET AL.: "Analysis of the pharmacodynamic activity of the mTOR inhibitor ridaforolimus (AP23573, MK-8669) in a", CANCER CHEMOTHERAPY AND PHARMACOLOGY, vol. 69, no. 5, JPN6016045369, 10 January 2012 (2012-01-10), pages 1369 - 1377, ISSN: 0003446555 *
CHANG SB, ET AL.: "Rapamycin inhibits proliferation of estrogen-receptor-positive breast cancer cells", JOURNAL OF SURGICAL RESEARCH, vol. 138, no. 1, JPN6016045363, 2007, pages 37 - 44, ISSN: 0003446553 *
DEY N, ET AL.: "Preclinical efficacy of a dual PI3K-mTOR inhibitor, BEZ235 in triple negative breast cancer", EUROPEAN JOURNAL OF CANCER, vol. Vol.47, Suppl.4, JPN6016045371, 2011, pages 17, ISSN: 0003446548 *
LEHMANN BD, ET AL.: "Identification of human triple-negative breast cancer subtypes and preclinical models for selection", THE JOURNAL OF CLINICAL INVESTIGATION, vol. 121, no. 7, JPN6016045362, July 2011 (2011-07-01), pages 2750 - 2767, ISSN: 0003446552 *
LIU T, ET AL.: "Combinatorial effects of lapatinib and rapamycin in triple-negative breast cancer cells", MOLECULAR CANCER THERAPEUTICS, vol. 10, no. 8, JPN6016045356, August 2011 (2011-08-01), pages 1460 - 1469, ISSN: 0003446550 *
YU K, ET AL.: "mTOR, a novel target in breast cancer: the effect of CCI-779, an mTOR inhibitor, in preclinical mode", ENDOCRINE-RELATED CANCER, vol. 8, no. 3, JPN6016045366, 2001, pages 249 - 258, ISSN: 0003446554 *
ZENG Q, ET AL.: "Treating triple-negative breast cancer by a combination of rapamycin and cyclophosphamide: an in viv", EUROPEAN JOURNAL OF CANCER, vol. 46, no. 6, JPN6016045359, 2010, pages 1132 - 1143, ISSN: 0003446551 *
ZHAO H, ET AL.: "The effect of mTOR inhibition alone or combined with MEK inhibitors on brain metastasis: an in vivo", BREAST CANCER RESEARCH AND TREATMENT, vol. 131, no. 2, JPN6016045353, 11 March 2012 (2012-03-11), pages 425 - 436, ISSN: 0003446549 *

Also Published As

Publication number Publication date
ES2678250T3 (es) 2018-08-09
BR112014022707A2 (pt) 2020-10-27
KR20140138951A (ko) 2014-12-04
EP2825169B1 (en) 2018-05-09
MX2014011118A (es) 2015-04-08
TWI635862B (zh) 2018-09-21
SG11201405724RA (en) 2014-10-30
AU2013202993A1 (en) 2013-10-03
IL234641B (en) 2020-04-30
MY178012A (en) 2020-09-29
PH12014502046B1 (en) 2020-10-16
PH12014502046A1 (en) 2014-12-10
MX360880B (es) 2018-11-21
NZ628407A (en) 2016-04-29
WO2013138553A1 (en) 2013-09-19
US20230338370A1 (en) 2023-10-26
KR102057359B1 (ko) 2019-12-18
TW201343165A (zh) 2013-11-01
NI201400112A (es) 2015-01-15
HK1201753A1 (en) 2015-09-11
CN104271139A (zh) 2015-01-07
EP2825169A1 (en) 2015-01-21
IL234641A0 (en) 2014-11-30
AU2013202993B2 (en) 2015-09-03
ZA201406701B (en) 2016-05-25
CA2867348A1 (en) 2013-09-19
JP6470820B2 (ja) 2019-02-13
JP2018052963A (ja) 2018-04-05
US20130245027A1 (en) 2013-09-19

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