JP2015510883A5 - - Google Patents
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- JP2015510883A5 JP2015510883A5 JP2014561022A JP2014561022A JP2015510883A5 JP 2015510883 A5 JP2015510883 A5 JP 2015510883A5 JP 2014561022 A JP2014561022 A JP 2014561022A JP 2014561022 A JP2014561022 A JP 2014561022A JP 2015510883 A5 JP2015510883 A5 JP 2015510883A5
- Authority
- JP
- Japan
- Prior art keywords
- aureus
- vaccine
- infection
- biofilm
- days
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 229960005486 vaccine Drugs 0.000 description 22
- -1 cefadroxyl Chemical class 0.000 description 16
- 208000015181 infectious disease Diseases 0.000 description 15
- 239000000427 antigen Substances 0.000 description 11
- 102000036639 antigens Human genes 0.000 description 11
- 108091007433 antigens Proteins 0.000 description 11
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 description 7
- 241000699670 Mus sp. Species 0.000 description 7
- 239000003242 anti bacterial agent Substances 0.000 description 7
- 230000001580 bacterial effect Effects 0.000 description 7
- WZRJTRPJURQBRM-UHFFFAOYSA-N 4-amino-n-(5-methyl-1,2-oxazol-3-yl)benzenesulfonamide;5-[(3,4,5-trimethoxyphenyl)methyl]pyrimidine-2,4-diamine Chemical compound O1C(C)=CC(NS(=O)(=O)C=2C=CC(N)=CC=2)=N1.COC1=C(OC)C(OC)=CC(CC=2C(=NC(N)=NC=2)N)=C1 WZRJTRPJURQBRM-UHFFFAOYSA-N 0.000 description 6
- 244000052769 pathogen Species 0.000 description 6
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- 108090000623 proteins and genes Proteins 0.000 description 6
- 238000002255 vaccination Methods 0.000 description 6
- 241000283973 Oryctolagus cuniculus Species 0.000 description 5
- 238000009472 formulation Methods 0.000 description 5
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- LOKCTEFSRHRXRJ-UHFFFAOYSA-I dipotassium trisodium dihydrogen phosphate hydrogen phosphate dichloride Chemical compound P(=O)(O)(O)[O-].[K+].P(=O)(O)([O-])[O-].[Na+].[Na+].[Cl-].[K+].[Cl-].[Na+] LOKCTEFSRHRXRJ-UHFFFAOYSA-I 0.000 description 4
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- SGKRLCUYIXIAHR-AKNGSSGZSA-N (4s,4ar,5s,5ar,6r,12ar)-4-(dimethylamino)-1,5,10,11,12a-pentahydroxy-6-methyl-3,12-dioxo-4a,5,5a,6-tetrahydro-4h-tetracene-2-carboxamide Chemical compound C1=CC=C2[C@H](C)[C@@H]([C@H](O)[C@@H]3[C@](C(O)=C(C(N)=O)C(=O)[C@H]3N(C)C)(O)C3=O)C3=C(O)C2=C1O SGKRLCUYIXIAHR-AKNGSSGZSA-N 0.000 description 2
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- MINDHVHHQZYEEK-UHFFFAOYSA-N (E)-(2S,3R,4R,5S)-5-[(2S,3S,4S,5S)-2,3-epoxy-5-hydroxy-4-methylhexyl]tetrahydro-3,4-dihydroxy-(beta)-methyl-2H-pyran-2-crotonic acid ester with 9-hydroxynonanoic acid Natural products CC(O)C(C)C1OC1CC1C(O)C(O)C(CC(C)=CC(=O)OCCCCCCCCC(O)=O)OC1 MINDHVHHQZYEEK-UHFFFAOYSA-N 0.000 description 2
- RXZBMPWDPOLZGW-XMRMVWPWSA-N (E)-roxithromycin Chemical compound O([C@@H]1[C@@H](C)C(=O)O[C@@H]([C@@]([C@H](O)[C@@H](C)C(=N/OCOCCOC)/[C@H](C)C[C@@](C)(O)[C@H](O[C@H]2[C@@H]([C@H](C[C@@H](C)O2)N(C)C)O)[C@H]1C)(C)O)CC)[C@H]1C[C@@](C)(OC)[C@@H](O)[C@H](C)O1 RXZBMPWDPOLZGW-XMRMVWPWSA-N 0.000 description 2
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- UIOFUWFRIANQPC-JKIFEVAISA-N Floxacillin Chemical compound N([C@@H]1C(N2[C@H](C(C)(C)S[C@@H]21)C(O)=O)=O)C(=O)C1=C(C)ON=C1C1=C(F)C=CC=C1Cl UIOFUWFRIANQPC-JKIFEVAISA-N 0.000 description 2
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| GB2463181B (en) | 2007-05-14 | 2013-03-27 | Univ New York State Res Found | Induction of a physiological dispersion response in bacterial cells in a biofilm |
| WO2015171693A1 (en) * | 2014-05-06 | 2015-11-12 | Virginia Commonwealth University | A new target for firmicutes and related bacteria: the prp protease |
| RU2765874C2 (ru) | 2016-10-26 | 2022-02-04 | МОДЕРНАТиЭкс, ИНК. | Матричные рибонуклеиновые кислоты для усиления иммунных ответов и способы их применения |
| JP2020512308A (ja) * | 2017-03-31 | 2020-04-23 | アセル，インコーポレイテッド | 細菌性感染症の患者を保護および治療するのに有用な、殺菌特性または静菌特性を有する細胞外基質組成物 |
| EP3720458A4 (en) | 2017-12-05 | 2021-12-08 | BioPlx, Inc. | METHODS AND COMPOSITIONS FOR PREVENTING MICROBIAL INFECTION |
| US11541105B2 (en) | 2018-06-01 | 2023-01-03 | The Research Foundation For The State University Of New York | Compositions and methods for disrupting biofilm formation and maintenance |
| JP2024504640A (ja) * | 2021-01-15 | 2024-02-01 | ユニバーシティ オブ ロチェスター | Ｓｔａｐｈｙｌｏｃｏｃｃｕｓ ａｕｒｅｕｓ抗原系核酸ワクチン |
| CN112940987B (zh) * | 2021-04-10 | 2022-10-14 | 福建省农业科学院畜牧兽医研究所 | 一株兔金黄色葡萄球菌及其在制备灭活疫苗中的应用 |
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| WO2004018624A2 (en) | 2002-08-20 | 2004-03-04 | Chiron Corporation | Random transposon insertion in staphylococcus aureus and use thereof to identify essential genes |
| KR101541383B1 (ko) * | 2006-03-30 | 2015-08-03 | 글락소스미스클라인 바이오로지칼즈 에스.에이. | 면역원성 조성물 |
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| US8318180B2 (en) | 2008-09-30 | 2012-11-27 | University Of Maryland, Baltimore | Protective vaccine against Staphylococcus aureus biofilms comprising cell wall-associated immunogens |
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